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141396-28-3 | 2-Piperidinecarboxylic acid, 1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-, hydrate (1:1), (2R,4R)-
CAS No: 141396-28-3 Catalog No: AG001GCF MDL No:MFCD28954374
Product Description
Catalog Number:
AG001GCF
Chemical Name:
2-Piperidinecarboxylic acid, 1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-, hydrate (1:1), (2R,4R)-
CAS Number:
141396-28-3
Molecular Formula:
C23H38N6O6S
Molecular Weight:
526.6494
MDL Number:
MFCD28954374
IUPAC Name:
(2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]pentanoyl]-4-methylpiperidine-2-carboxylic acid;hydrate
InChI:
InChI=1S/C23H36N6O5S.H2O/c1-14-8-10-29(18(12-14)22(31)32)21(30)17(6-4-9-26-23(24)25)28-35(33,34)19-7-3-5-16-11-15(2)13-27-20(16)19;/h3,5,7,14-15,17-18,27-28H,4,6,8-13H2,1-2H3,(H,31,32)(H4,24,25,26);1H2/t14-,15?,17+,18-;/m1./s1
InChI Key:
AIEZTKLTLCMZIA-CZSXTPSTSA-N
SMILES:
NC(=N)NCCC[C@@H](C(=O)N1CC[C@H](C[C@@H]1C(=O)O)C)NS(=O)(=O)c1cccc2c1NCC(C2)C.O
Properties
Complexity:
887
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
3
Defined Bond Stereocenter Count:
0
Exact Mass:
526.257g/mol
Formal Charge:
0
Heavy Atom Count:
36
Hydrogen Bond Acceptor Count:
9
Hydrogen Bond Donor Count:
6
Isotope Atom Count:
0
Molecular Weight:
526.653g/mol
Monoisotopic Mass:
526.257g/mol
Rotatable Bond Count:
9
Topological Polar Surface Area:
190A^2
Undefined Atom Stereocenter Count:
1
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Use of argatroban and catheter-directed thrombolysis with alteplase in an oncology patient with heparin-induced thrombocytopenia with thrombosis. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20140501 |
| Heparin-induced thrombocytopenia in essential thrombocytosis. | Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 20121101 |
| Bleeding risk factors associated with argatroban therapy in the critically ill. | Journal of thrombosis and thrombolysis 20121101 |
| Pharmacokinetic evaluation of argatroban for the treatment of acute coronary syndrome. | Expert opinion on drug metabolism & toxicology 20121101 |
| Treatment outcomes of heparin-induced thrombocytopenia in subarachnoid hemorrhage patients: a 4-year, retrospective single-center review. | Neurocritical care 20121001 |
| Therapeutic administration of the direct thrombin inhibitor argatroban reduces hepatic inflammation in mice with established fatty liver disease. | The American journal of pathology 20121001 |
| Measuring direct thrombin inhibitors with routine and dedicated coagulation assays: which assay is helpful? | American journal of clinical pathology 20121001 |
| Direct thrombin inhibitors for management of heparin-induced thrombocytopenia in patients receiving renal replacement therapy: comparison of clinical outcomes. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20120915 |
| Translational success stories: development of direct thrombin inhibitors. | Circulation research 20120914 |
| Outcomes after heparin-induced thrombocytopenia in patients with Propaten vascular grafts. | Annals of vascular surgery 20120801 |
| Use of the chromogenic factor X assay in patients transitioning from argatroban to warfarin therapy. | Pharmacotherapy 20120601 |
| In vivo fluorescence imaging of atherosclerotic plaques with activatable cell-penetrating peptides targeting thrombin activity. | Integrative biology : quantitative biosciences from nano to macro 20120601 |
| Alternative anticoagulation during cardiovascular procedures in pediatric patients with heparin-induced thrombocytopenia. | The journal of extra-corporeal technology 20120601 |
| Thrombin activity associated with neuronal damage during acute focal ischemia. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20120530 |
| Thrombin inhibition profiles in healthy individuals and thrombophilic patients. | Thrombosis and haemostasis 20120501 |
| Recognition of heparin-induced thrombocytopenia and initiation of argatroban therapy after cardiothoracic surgery in the intensive care unit. | The Journal of thoracic and cardiovascular surgery 20120501 |
| Development of a fast and simple liquid chromatography-tandem mass spectrometry method for the quantitation of argatroban in patient plasma samples. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120415 |
| Results of a consensus meeting on the use of argatroban in patients with heparin-induced thrombocytopenia requiring antithrombotic therapy - a European Perspective. | Thrombosis research 20120401 |
| Argatroban therapy for heparin-induced thrombocytopenia during pregnancy in a woman with hereditary antithrombin deficiency. | The journal of obstetrics and gynaecology research 20120401 |
| [Anesthesia for a hemodialysis patient with HIT undergoing CABG using argatroban]. | Masui. The Japanese journal of anesthesiology 20120401 |
| High-dose argatroban for treatment of heparin-induced thrombocytopenia with thrombosis: a case report and review of laboratory considerations. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20120315 |
| The argatroban and tissue-type plasminogen activator stroke study: final results of a pilot safety study. | Stroke 20120301 |
| The argatroban and tissue-type plasminogen activator stroke study: final results of a pilot safety study. | Stroke 20120301 |
| Argatroban anticoagulation for heparin induced thrombocytopenia in patients with ventricular assist devices. | Minerva anestesiologica 20120301 |
| Development and implementation of a comprehensive heparin-induced thrombocytopenia recognition and management protocol. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20120201 |
| Parenteral anticoagulants: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. | Chest 20120201 |
| Combined argatroban and anti-oxidative agents prevents increased vascular contractility to thrombin and other ligands after subarachnoid haemorrhage. | British journal of pharmacology 20120101 |
| Novel insights into the delayed vasospasm following subarachnoid haemorrhage: importance of proteinase signalling. | British journal of pharmacology 20120101 |
| A case of acute coronary artery occlusion associated with very rapid onset heparin-induced thrombosis without thrombocytopenia. | Internal medicine (Tokyo, Japan) 20120101 |
| Hitting back HIT. | Annals of cardiac anaesthesia 20120101 |
| Hemodialysis with a dialyzer loaded with argatroban may be performed in vivo without a systemic anticoagulant. | Blood purification 20120101 |
| Newer anticoagulants for the prevention of venous thromboembolism. | The National medical journal of India 20120101 |
| Old and new antithrombotic drugs in neonates and infants. | Seminars in fetal & neonatal medicine 20111201 |
| Identifying patient- and treatment-related factors related to amputation risk in cases of heparin-induced thrombocytopenia treated with argatroban. | International angiology : a journal of the International Union of Angiology 20111201 |
| Immobilization of anticoagulant-loaded liposomes on cell surfaces by DNA hybridization. | Biomaterials 20111101 |
| Water-soluble argatroban for antithrombogenic surface coating of tissue-engineered cardiovascular tissues. | Journal of biomedical materials research. Part B, Applied biomaterials 20111101 |
| Systemic administration of argatroban inhibits protease-activated receptor-1 expression in perihematomal tissue in rats with intracerebral hemorrhage. | Brain research bulletin 20111010 |
| Monitoring of the anticoagulants argatroban and lepirudin: a comparison of laboratory methods. | Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20111001 |
| Direct thrombin inhibitors. | British journal of clinical pharmacology 20111001 |
| Effects of argatroban as an anticoagulant for intermittent veno-venous hemofiltration (IVVH) in patients at high risk of bleeding. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20110901 |
| Heparin-induced thrombocytopenia type II because of heparin-coated polytetrafluoroethylene graft used to bypass. | Annals of vascular surgery 20110801 |
| Management of argatroban surrounding a lumbar puncture: a case report. | American journal of hematology 20110801 |
| Implementation of an individualized argatroban protocol in an academic medical center. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20110715 |
| Argatroban therapy in pediatric patients requiring nonheparin anticoagulation: an open-label, safety, efficacy, and pharmacokinetic study. | Pediatric blood & cancer 20110701 |
| Long-term animal implantation study of biotube-autologous small-caliber vascular graft fabricated by in-body tissue architecture. | Journal of biomedical materials research. Part B, Applied biomaterials 20110701 |
| Profiling of active thrombin in human blood by supramolecular complexes. | Angewandte Chemie (International ed. in English) 20110627 |
| Anticoagulation with argatroban for elective percutaneous coronary intervention: population pharmacokinetics and pharmacokinetic-pharmacodynamic relationship of coagulation parameters. | Journal of clinical pharmacology 20110601 |
| [Diagnosis and treatment of heparin-induced thrombocytopenia]. | Deutsche medizinische Wochenschrift (1946) 20110501 |
| Argatroban for elective percutaneous coronary intervention: the ARG-E04 multi-center study. | International journal of cardiology 20110414 |
| Practical viewpoints on the diagnosis and management of heparin-induced thrombocytopenia. | Seminars in thrombosis and hemostasis 20110401 |
| [Interventional lung assist membrane ventilator. Successful use despite heparin-induced thrombocytopenia type II]. | Der Anaesthesist 20110301 |
| Evaluation of empiric versus nomogram-based direct thrombin inhibitor management in patients with suspected heparin-induced thrombocytopenia. | American journal of hematology 20110301 |
| Use of argatroban as a procedural and bridging anticoagulant in a patient undergoing carotid endarterectomy with concomitant atrial fibrillation. | The Annals of pharmacotherapy 20110301 |
| Argatroban therapy using enzymatic anti-factor IIa monitoring. | The Annals of pharmacotherapy 20110301 |
| [Efficacy of regional administration of urokinase and argatroban via small saphenous vein catheter for treatment of acute deep venous thrombosis in the lower limb]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20110301 |
| Venous limb gangrene and fatal hemorrhage: adverse consequences of HIT 'overdiagnosis' in a patient with antiphospholipid syndrome. | American journal of hematology 20110201 |
| Thrombosis prophylaxis in critically ill patients. | Wiener medizinische Wochenschrift (1946) 20110201 |
| Direct thrombin and factor Xa inhibitors in children: a quest for new anticoagulants for children. | Wiener medizinische Wochenschrift (1946) 20110201 |
| [Synthetic protease inhibitors for the treatment of DIC]. | Rinsho byori. The Japanese journal of clinical pathology 20110201 |
| Pharmacokinetic and pharmacodynamic basis for effective argatroban dosing in pediatrics. | Journal of clinical pharmacology 20110101 |
| A patient with 'spontaneous' heparin-induced thrombocytopenia and thrombosis after undergoing knee replacement. | Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20110101 |
| A randomized, open-label pilot study comparing desirudin and argatroban in patients with suspected heparin-induced thrombocytopenia with or without thrombosis: PREVENT-HIT Study. | American journal of therapeutics 20110101 |
| Hypereosinophilic syndrome with cardiac involvement in a pregnant patient with multiple sclerosis. | Texas Heart Institute journal 20110101 |
| An optimized method to assess in vivo efficacy of antithrombotic drugs using optical coherence tomography and a modified Doppler flow system. | Journal of pharmacological and toxicological methods 20110101 |
| Argatroban 'reversal' is caused by nonphysiologic stimulation of coagulation, not activated factor VII. | Journal of cardiothoracic and vascular anesthesia 20101201 |
| Carbon monoxide releasing molecule-2 enhances coagulation and diminishes fibrinolytic vulnerability in plasma exposed to heparin or argatroban. | Anesthesia and analgesia 20101201 |
| Comparison of bivalirudin and argatroban for the management of heparin-induced thrombocytopenia. | Pharmacotherapy 20101201 |
| Extracorporeal membrane oxygenation bridging to lung transplant complicated by heparin-induced thrombocytopenia. | Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 20101201 |
| Argatroban administration reduces leukocyte adhesion and improves capillary perfusion within the intestinal microcirculation in experimental sepsis. | Thrombosis and haemostasis 20101101 |
| [Concept of branch atheromatous disease (BAD) and its clinical significance]. | Rinsho shinkeigaku = Clinical neurology 20101101 |
| Difficult management of anticoagulation with argatroban in a patient undergoing on-pump cardiac surgery. | Journal of cardiothoracic and vascular anesthesia 20101001 |
| Safety and efficacy of the argatroban therapy during the early post-cardiac surgery period. | Journal of thrombosis and thrombolysis 20101001 |
| Pharmacotherapy in the critically ill obese patient. | Critical care clinics 20101001 |
| Pharmacology of argatroban. | Expert review of hematology 20101001 |
| Low dose of argatroban saline flushes anticoagulation in hemodialysis patients with high risk of bleeding. | Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20100801 |
| Argatroban and renal replacement therapy in a morbidly obese patient with heparin-induced thrombocytopenia: a case report. | Thrombosis research 20100801 |
| Treatment with argatroban in one haemodialysed patient with a heparin-induced thrombocytopenia and thrombotic complications. | Internal and emergency medicine 20100801 |
| Serious acute coronary thrombosis associated with heparin-induced thrombocytopenia in off-pump coronary artery bypass grafting. | Interactive cardiovascular and thoracic surgery 20100801 |
| Apixaban, a direct factor Xa inhibitor, inhibits tissue-factor induced human platelet aggregation in vitro: comparison with direct inhibitors of factor VIIa, XIa and thrombin. | Thrombosis and haemostasis 20100801 |
| Fondaparinux therapy in a hemodialysis patient with heparin-induced thrombocytopenia type II. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20100701 |
| [Heparin-induced thrombocytopenia after on-pump coronary artery bypass grafting]. | Kyobu geka. The Japanese journal of thoracic surgery 20100601 |
| An overview of heparin-induced thrombocytopenia. | Journal of pharmacy practice 20100601 |
| The direct thrombin inhibitors (argatroban, bivalirudin and lepirudin) and the indirect Xa-inhibitor (danaparoid) increase fibrin network porosity and thus facilitate fibrinolysis. | Thrombosis and haemostasis 20100501 |
| Prolonged elevation of plasma argatroban in a cardiac transplant patient with a suspected history of heparin-induced thrombocytopenia with thrombosis. | Transfusion 20100401 |
| Argatroban as a substitute of heparin during cardiopulmonary bypass: a safe alternative? | Interactive cardiovascular and thoracic surgery 20100401 |
| The direct thrombin inhibitor argatroban effectively prevents cardiac catheter thrombosis in vitro. | Thrombosis and haemostasis 20100401 |
| Rationale and design of the PREVENT-HIT study: a randomized, open-label pilot study to compare desirudin and argatroban in patients with suspected heparin-induced thrombocytopenia with or without thrombosis. | Clinical therapeutics 20100401 |
| Cooperative antithrombotic effect from the simultaneous inhibition of thrombin and factor Xa. | Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20100301 |
| Laboratory monitoring of new anticoagulants. | American journal of hematology 20100301 |
| Thrombolytic therapy and thrombectomy in phlegmasia cerulea dolens. | The journal of the Royal College of Physicians of Edinburgh 20100301 |
| Review: recent advances in argatroban-warfarin transition in patients with heparin-induced thrombocytopenia. | Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20100201 |
| Heparin-induced thrombocytopenia in two patients undergoing abdominal aortic aneurysm surgery. | Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20100201 |
| Inhibition of thrombin action ameliorates insulin resistance in type 2 diabetic db/db mice. | Endocrinology 20100201 |
| Heparin-induced thrombocytopenia and cardiac surgery. | Current opinion in anaesthesiology 20100201 |
| Simultaneous use of argatroban and heparin during cardiopulmonary bypass. | Asian cardiovascular & thoracic annals 20100201 |
| Impact of renal function on argatroban therapy during percutaneous coronary intervention. | Journal of thrombosis and thrombolysis 20100101 |
| Anticoagulation with argatroban in a parturient with heparin-induced thrombocytopenia. | International journal of obstetric anesthesia 20100101 |
| An evaluation of monitoring possibilities of argatroban using rotational thromboelastometry and activated partial thromboplastin time. | Acta anaesthesiologica Scandinavica 20100101 |
| Autologous small-caliber 'biotube' vascular grafts with argatroban loading: a histomorphological examination after implantation to rabbits. | Journal of biomedical materials research. Part B, Applied biomaterials 20100101 |
| Quantitation of argatroban in plasma using liquid chromatography electrospray tandem mass spectrometry (UPLC-ESI-MS/MS). | Methods in molecular biology (Clifton, N.J.) 20100101 |
| Argatroban therapy for heparin-induced thrombocytopenia in ICU patients with multiple organ dysfunction syndrome: a retrospective study. | Critical care (London, England) 20100101 |
| Argatroban in the management of heparin-induced thrombocytopenia. | Vascular health and risk management 20100101 |
| Thrombin inhibition in subarachnoid hemorrhage. | Neurosurgery 20091201 |
| [Heparin-induced thrombocytopenia type II with thrombosis in an intensive care patient: therapy management using the direct thrombin inhibitor argatroban]. | Der Anaesthesist 20091101 |
| RapidTEG observation suggests activation of factor VII may overcome argatroban-induced coagulopathy. | Journal of cardiothoracic and vascular anesthesia 20091001 |
| Thrombin generation by intimal tissue factor contributes to thrombus formation on macrophage-rich neointima but not normal intima of hyperlipidemic rabbits. | Atherosclerosis 20091001 |
| Heparin-induced thrombocytopenia with multiple organized thrombi accompanied by unusual cholesterin deposition: autopsy case after long-term follow up. | Pathology international 20091001 |
| [Anticoagulation in critically ill patient]. | Wiener medizinische Wochenschrift (1946) 20091001 |
| Argatroban dosage requirements and outcomes in intensive care versus non-intensive care patients. | Pharmacotherapy 20090901 |
| [Anesthetic management for a patient with heparin-induced thrombocytopenia (HIT) undergoing off-pump coronary bypass surgery using argatroban, a direct thrombin inhibitor]. | Masui. The Japanese journal of anesthesiology 20090901 |
| A comparison of direct thrombin inhibitors in the treatment of Heparin-Induced Thrombocytopenia: a single institution experience. | Journal of thrombosis and thrombolysis 20090801 |
| Anticoagulation with the direct thrombin inhibitor argatroban in patients presenting with acute coronary syndromes. | Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20090801 |
| HeartMate II implantation in patients with heparin-induced thrombocytopenia type II. | The Annals of thoracic surgery 20090801 |
| Clinical investigation in ACS and PCI: shooting in the dark at a moving target. | Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20090801 |
| Anterior spinal artery as a collateral channel in patients with acute bilateral vertebral artery occlusions. Two case reports. | Neurologia medico-chirurgica 20090801 |
| Stabilization of the E* form turns thrombin into an anticoagulant. | The Journal of biological chemistry 20090724 |
| Dosing patterns and outcomes in African American, Asian, and Hispanic patients with heparin-induced thrombocytopenia treated with argatroban. | Journal of thrombosis and thrombolysis 20090701 |
| Influence of antithrombin and argatroban on disseminated intravascular coagulation parameters in a patient with septic shock. | Thrombosis research 20090701 |
| INR matters: a case on managing argatroban for bridging oral anticoagulation in a patient with heparin induced thrombocytopenia type II after mechanical heart valve replacement. | Thrombosis research 20090601 |
| Argatroban for anticoagulation in continuous renal replacement therapy. | Critical care medicine 20090601 |
| The effect of argatroban on activated protein C resistance. | American journal of clinical pathology 20090601 |
| Argatroban and bivalirudin compared to unfractionated heparin in preventing thrombus formation on mechanical heart valves. Results of an in-vitro study. | Thrombosis and haemostasis 20090601 |
| Heparin-induced thrombocytopenia. A contemporary clinical approach to diagnosis and management. | Chest 20090601 |
| [Clinical observation of heparin-induced thrombocytopenia]. | Zhonghua yi xue za zhi 20090526 |
| Thrombin inhibition by argatroban ameliorates early brain injury and improves neurological outcomes after experimental subarachnoid hemorrhage in rats. | Stroke 20090401 |
| Argatroban and catheter-directed thrombolysis with alteplase for limb- and graft-threatening thromboses in a patient with a history of HIT. | American journal of hematology 20090401 |
| [A study of the dosage of argatroban for anticoagulation effect in the patients undergoing high volume hemofiltration]. | Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20090401 |
| Comparison of activated clotting times obtained using Hemochron and Medtronic analysers in patients receiving anti-thrombin therapy during cardiac catheterisation. | Thrombosis and haemostasis 20090301 |
| A report of outcomes after orthotopic liver transplant with allografts from heparin antibody-positive donors. | Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 20090301 |
| [Argatroban treatment of heparin-induced immune-mediated thrombocytopenia]. | Ugeskrift for laeger 20090216 |
| [Heparin-induced thrombocytopenia]. | Ugeskrift for laeger 20090216 |
| The effect of ex vivo anticoagulants on whole blood platelet aggregation. | Platelets 20090201 |
| 84-year-old woman with hemodialysis-associated shortness of breath. | Mayo Clinic proceedings 20090201 |
| Heparin-induced thrombocytopenia: what clinicians need to know. | Thrombosis and haemostasis 20090201 |
| [Use of argatroban during cardiopulmonary bypass for atrial septal defect with heparin induced thrombocytopenia after introduction of dialysis]. | Kyobu geka. The Japanese journal of thoracic surgery 20090201 |
| Argatroban for anticoagulation in continuous renal replacement therapy. | Critical care medicine 20090101 |
| 'Drug dosing in the intensive care unit: the critically ill are a special population too'. | Critical care medicine 20090101 |
| Effects of critical illness and organ failure on therapeutic argatroban dosage requirements in patients with suspected or confirmed heparin-induced thrombocytopenia. | The Annals of pharmacotherapy 20090101 |
| Weight-based argatroban dosing nomogram for treatment of heparin-induced thrombocytopenia. | The Annals of pharmacotherapy 20090101 |
| Argatroban therapy in heparin-induced thrombocytopenia. | AACN advanced critical care 20090101 |
| Reducing harm associated with anticoagulation: practical considerations of argatroban therapy in heparin-induced thrombocytopenia. | Drug safety 20090101 |
| Use of argatroban during multi-organ procurement: pharmacokinetics and sequelae in recipient of transplanted liver. | Clinical transplantation 20090101 |
| Argatroban: a review of its use in the management of heparin-induced thrombocytopenia. | American journal of cardiovascular drugs : drugs, devices, and other interventions 20090101 |
| Heparin-induced thrombocytopenia: when a low platelet count is a mandate for anticoagulation. | Hematology. American Society of Hematology. Education Program 20090101 |
| Argatroban enhances fibrinolysis by differential inhibition of thrombin-mediated activation of thrombin activatable fibrinolysis inhibitor and factor XIII. | Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20081201 |
| Successful use of argatroban during the third trimester of pregnancy: case report and review of the literature. | Pharmacotherapy 20081201 |
| Risk factors for major bleeding in patients with heparin-induced thrombocytopenia treated with argatroban: a retrospective study. | Journal of cardiovascular pharmacology 20081201 |
| Management of anticoagulation in patients with subacute heparin-induced thrombocytopenia scheduled for heart transplantation. | Blood 20081115 |
| Heparin-induced thrombocytopenia (HIT) causing pulmonary emboli during coronary intervention. | Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20081115 |
| The thrombin inhibitor Argatroban reduces breast cancer malignancy and metastasis via osteopontin-dependent and osteopontin-independent mechanisms. | Breast cancer research and treatment 20081101 |
| Thrombin enhances the production of monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 in cultured rat glomerular epithelial cells. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20081101 |
| Use of Argatroban for anticoagulation during cardiopulmonary bypass in a patient with heparin allergy. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20081101 |
| Management of uremic patients with heparin-induced thrombocytopenia requiring hemodialysis. | Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20081001 |
| Complete salvage of impending free flap failure in heparin induced thrombocytopenia by emergent institution of therapy with argatroban. | Journal of plastic, reconstructive & aesthetic surgery : JPRAS 20081001 |
| Rivaroxaban--an oral, direct Factor Xa inhibitor--has potential for the management of patients with heparin-induced thrombocytopenia. | British journal of haematology 20081001 |
| [Three cases of small brain infarction in the lateral wall of the fourth ventricle presenting with paroxysmal positional vertigo and vomiting]. | Rinsho shinkeigaku = Clinical neurology 20081001 |
| Inhibition of osteopontin dependent carcinogenesis. | Journal of cancer research and clinical oncology 20080801 |
| Argatroban use in heparin-induced thrombocytopenia. | Expert opinion on pharmacotherapy 20080801 |
| Therapeutic effect of argatroban on rheumatoid vasculitis with antiphosphatidylserine-prothrombin complex antibody. | Archives of dermatology 20080801 |
| Parenteral anticoagulants: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edition). Addendum. | Chest 20080801 |
| Influence of continuous veno-venous hemofiltration on argatroban clearance in a patient with septic shock. | Intensive care medicine 20080701 |
| Efficacy and safety of argatroban in patients with heparin induced thrombocytopenia undergoing endovascular intervention for peripheral arterial disease. | Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20080701 |
| Transition from argatroban to oral anticoagulation with phenprocoumon or acenocoumarol: effect on coagulation factor testing. | Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20080701 |
| What is the optimal anticoagulation level with argatroban during percutaneous coronary intervention? | Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20080701 |
| Interaction between thrombin mutant W215A/E217A and direct thrombin inhibitor. | Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20080701 |
| Effect of body mass index on Argatroban therapy during percutaneous coronary intervention. | Journal of thrombosis and thrombolysis 20080601 |
| Influence of direct thrombin inhibitor argatroban on coagulation assays in healthy individuals, patients under oral anticoagulation therapy and patients with liver dysfunction. | Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20080601 |
| Parenteral anticoagulants: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). | Chest 20080601 |
| Argatroban in short-term percutaneous ventricular assist subsequent to heparin-induced thrombocytopenia. | The journal of extra-corporeal technology 20080601 |
| Heparins, low-molecular-weight heparins, and pentasaccharides: use in the older patient. | Cardiology clinics 20080501 |
| New anticoagulant agents: direct thrombin inhibitors. | Cardiology clinics 20080501 |
| Argatroban as a primary or secondary postoperative anticoagulant in patients implanted with ventricular assist devices. | The Annals of thoracic surgery 20080501 |
| Argatroban as a primary or secondary postoperative anticoagulant in patients implanted with ventricular assist devices. Invited commentary. | The Annals of thoracic surgery 20080501 |
| Heparin-induced thrombocytopenia: a review of current pharmacologic treatment. | Connecticut medicine 20080501 |
| Efficacy and safety of argatroban with or without glycoprotein IIb/IIIa inhibitor in patients with heparin induced thrombocytopenia undergoing percutaneous coronary intervention for acute coronary syndrome. | Journal of thrombosis and thrombolysis 20080401 |
| Argatroban therapy in patients with hepatic and renal impairment. | European journal of anaesthesiology 20080401 |
| [Heparin induced thrombocytopenia and anticoagulation in renal replacemant therapy]. | Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20080401 |
| Prolonged half-life of argatroban in patients with renal dysfunction and antiphospholipid antibody syndrome being treated for heparin-induced thrombocytopenia. | American journal of hematology 20080301 |
| Reduced argatroban doses after coronary artery bypass graft surgery. | The Annals of pharmacotherapy 20080301 |
| Considerations for drug dosing post coronary artery bypass graft surgery. | The Annals of pharmacotherapy 20080301 |
| Standardizing the management of heparin-induced thrombocytopenia. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080215 |
| The laboratory diagnosis and clinical management of patients with heparin-induced thrombocytopenia: an update. | Seminars in thrombosis and hemostasis 20080201 |
| Argatroban therapy in patients with coronary artery disease and heparin-induced thrombocytopenia. | Cardiology 20080101 |
| Visual evaluation of blood coagulation during mural thrombogenesis under high shear blood flow. | Thrombosis research 20080101 |
| Complete 1H and 13C assignments of (21R) and (21S) diastereomers of argatroban. | Magnetic resonance in chemistry : MRC 20080101 |
| Heparin-induced thrombocytopenia complicating hemodialysis. | Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20080101 |
| Thrombelastography in a patient with heparin-induced thrombocytopenia treated with argatroban. | Anesthesia and analgesia 20080101 |
| [Patient with heparin-induced thrombocytopenia type II and implanted left ventricular assist device]. | Der Anaesthesist 20080101 |
| Fondaparinux versus direct thrombin inhibitor therapy for the management of heparin-induced thrombocytopenia (HIT)--bridging the River Coumarin. | Thrombosis and haemostasis 20080101 |
| Ultrasound-guided supraclavicular block in a patient anticoagulated with argatroban. | Pain practice : the official journal of World Institute of Pain 20080101 |
| Comparison of the ecarin chromogenic assay and different aPTT assays for the measurement of argatroban concentrations in plasma from healthy individuals and from coagulation factor deficient patients. | Thrombosis research 20080101 |
| Prediction of the therapeutic index of marketed anti-coagulants and anti-platelet agents by guinea pig models of thrombosis and hemostasis. | Thrombosis research 20080101 |
| Argatroban anticoagulation in renal dysfunction: a literature analysis. | Nephron. Clinical practice 20080101 |
| Argatroban anticoagulation in intensive care patients: effects of heart failure and multiple organ system failure. | Journal of intensive care medicine 20080101 |
| Argatroban anticoagulation for cardiac surgery with cardiopulmonary bypass in an infant with double outlet right ventricle and a history of heparin-induced thrombocytopenia. | Congenital heart disease 20080101 |
| Treatment of intracardiac thrombi with argatroban. | Acute cardiac care 20080101 |
| Management of a pediatric patient on the Berlin Heart Excor ventricular assist device with argatroban after heparin-induced thrombocytopenia. | ASAIO journal (American Society for Artificial Internal Organs : 1992) 20080101 |
| The use of alternative anti-coagulation strategies for a nocturnal home hemodialysis patient with heparin-induced thrombocytopenia. | CANNT journal = Journal ACITN 20080101 |
| Thrombin enhances glioma growth. | Acta neurochirurgica. Supplement 20080101 |
| Inhibition of thrombin generation in recalcified plasma. | Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20071201 |
| Catheter-directed thrombolysis of acute lower extremity arterial thrombosis in a patient with heparin-induced thrombocytopenia. | Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20071201 |
| [Are new anticoagulants better?]. | Investigacion clinica 20071201 |
| Development of self-expandable covered stents. | Journal of biomedical materials research. Part B, Applied biomaterials 20071101 |
| Seizures, headache and thrombocytopenia: diagnosis and treatment do not always come in a standard sequence. | Internal and emergency medicine 20071001 |
| Argatroban therapy for heparin-induced thrombocytopenia in acutely ill patients. | Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20071001 |
| [Heparin-induced thrombocytopenia]. | Revista espanola de cardiologia 20071001 |
| A case of heparin-induced thrombocytopenia with repeated episodes of acute lower extremity arterial thromboembolism during a short time. | Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 20071001 |
| Influence of argatroban on coagulation parameters in heparin-induced thrombocytopenia patients after cardiothoracic surgery. | Journal of thrombosis and haemostasis : JTH 20070901 |
| Heparin induced thrombocytopenia: diagnosis and management update. | Postgraduate medical journal 20070901 |
| Percutaneous coronary interventions in patients with heparin-induced thrombocytopenia. | Current cardiology reports 20070901 |
| Heparin induced thrombocytopenia: pathogenetic, clinical, diagnostic and therapeutic aspects. | Cardiovascular & hematological disorders drug targets 20070901 |
| Argatroban anticoagulation in obese versus nonobese patients: implications for treating heparin-induced thrombocytopenia. | Journal of clinical pharmacology 20070801 |
| Heparin-induced thrombocytopenia II-induced critical limb ischaemia treated with urokinase and argatroban. | Thrombosis and haemostasis 20070801 |
| Involvement of thrombin and mitogen-activated protein kinase pathways in hemorrhagic brain injury. | Experimental neurology 20070701 |
| Argatroban in extracorporeal membrane oxygenation. | Artificial organs 20070601 |
| Efficacy of anti-coagulant treatment with argatroban on cardioembolic stroke. | Journal of neurology 20070501 |
| Argatroban anticoagulation in critically ill patients. | The Annals of pharmacotherapy 20070501 |
| Argatroban anticoagulation for renal replacement therapy in patients with heparin-induced thrombocytopenia after cardiovascular surgery. | The Journal of thoracic and cardiovascular surgery 20070501 |
| Heparin-induced thrombocytopenia and thrombosis. | American journal of orthopedics (Belle Mead, N.J.) 20070501 |
| Assessing nonlinearity in compartment models via the relative curvature measure. | Journal of pharmacokinetics and pharmacodynamics 20070401 |
| Heparin-induced thrombocytopenia in intensive care patients. | Critical care medicine 20070401 |
| Heparin-induced thrombocytopenia: treatment options and special considerations. | Pharmacotherapy 20070401 |
| Impact of smart infusion technology on administration of anticoagulants (unfractionated Heparin, Argatroban, Lepirudin, and Bivalirudin). | The American journal of cardiology 20070401 |
| Essentials of anticoagulation in hemodialysis. | Hemodialysis international. International Symposium on Home Hemodialysis 20070401 |
| Argatroban for anticoagulation in pediatric patients with heparin-induced thrombocytopenia requiring extracorporeal life support. | Journal of pediatric hematology/oncology 20070401 |
| Differential effects of direct thrombin inhibitors and antithrombin-dependent anticoagulants on the dynamics of clot formation. | Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20070301 |
| Platelet activity, coagulation, and fibrinolysis during exercise in healthy males: effects of thrombin inhibition by argatroban and enoxaparin. | Arteriosclerosis, thrombosis, and vascular biology 20070201 |
| [Two surgical case reports showing atypical heparin-induced thrombocytopenia]. | Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen 20070201 |
| Alternative anticoagulation management strategies for the patient with heparin-induced thrombocytopenia undergoing cardiac surgery. | Journal of cardiothoracic and vascular anesthesia 20070201 |
| [Bilateral cerebellar infarction caused by intracranial dissection of the vertebral artery after long periods of 'Shiatsu']. | No to shinkei = Brain and nerve 20070201 |
| Argatroban for anticoagulation during cardiac surgery. | European journal of haematology 20070201 |
| Hydroxyethyl starch enhances argatroban-mediated decreases in clot propagation and strength by diminishing thrombin-fibrinogen interactions. | Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20070101 |
| Direct thrombin inhibition during percutaneous coronary intervention in patients with heparin-induced thrombocytopenia. | Expert review of cardiovascular therapy 20070101 |
| Anticoagulation options for patients with heparin-induced thrombocytopenia requiring renal support in the intensive care unit. | Contributions to nephrology 20070101 |
| Argatroban anticoagulation for heparin-induced thrombocytopenia in elderly patients. | Drugs & aging 20070101 |
| Heparin-induced thrombocytopenia: a general review. | Journal of infusion nursing : the official publication of the Infusion Nurses Society 20070101 |
| A case series describing the use of argatroban in patients on extracorporeal circulation. | ASAIO journal (American Society for Artificial Internal Organs : 1992) 20070101 |
| Argatroban therapy in women with heparin-induced thrombocytopenia. | Journal of women's health (2002) 20070101 |
| Anticoagulation for acute coronary syndromes: from heparin to direct thrombin inhibitors. | Reviews in cardiovascular medicine 20070101 |
| Direct thrombin inhibitors: alternatives to heparin. | Vascular 20070101 |
| Heparin-induced thrombocytopenia in the critical care setting: diagnosis and management. | Critical care medicine 20061201 |
| Effect of renal function on argatroban therapy in heparin-induced thrombocytopenia. | Journal of thrombosis and thrombolysis 20061201 |
| Heparin-induced thrombocytopenia: advances in diagnosis and treatment. | Critical care nurse 20061201 |
| Prolonged anticoagulation after discontinuation of argatroban and warfarin therapy in an obese patient with heparin-induced thrombocytopenia. | Pharmacotherapy 20061201 |
| Heparin-induced thrombocytopenia without thrombosis: an evidence-based review of current literature. | Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 20061201 |
| [Argatroban]. | Nihon rinsho. Japanese journal of clinical medicine 20061028 |
| Anticoagulation strategies for treatment of ischemic stroke and antiphospholipid syndrome: case report and review of the literature. | Pharmacotherapy 20061001 |
| Systemic anticoagulation with argatroban during arteriovenous dialysis graft thrombolysis. | Journal of vascular and interventional radiology : JVIR 20061001 |
| Flavonoids inhibit the amidolytic activity of human thrombin. | Biochimie 20060901 |
| Anticoagulation with argatroban in patients with heparin-induced thrombocytopenia antibodies after cardiovascular surgery with cardiopulmonary bypass: first results from the ARG-E03 trial. | The Journal of thoracic and cardiovascular surgery 20060901 |
| Argatroban tPA stroke study: study design and results in the first treated cohort. | Archives of neurology 20060801 |
| [Two cases of heparin-induced thrombocytopenia (HIT) and a review of the literature]. | [Rinsho ketsueki] The Japanese journal of clinical hematology 20060801 |
| On-chip titration of an anticoagulant argatroban and determination of the clotting time within whole blood or plasma using a plug-based microfluidic system. | Analytical chemistry 20060715 |
| Heparin-induced thrombocytopenia and cardiovascular diseases. | American heart journal 20060701 |
| Argatroban, bivalirudin, and lepirudin do not decrease clot propagation and strength as effectively as heparin-activated antithrombin in vitro. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20060601 |
| Recognition and management of heparin-induced thrombocytopenia in pediatric cardiopulmonary bypass patients. | The Annals of thoracic surgery 20060601 |
| Thrombotic end point for assessing argatroban therapy for heparin-induced thrombocytopenia: learning from secondary analyses of prospective studies. | Chest 20060601 |
| Effects of argatroban therapy, demographic variables, and platelet count on thrombotic risks in heparin-induced thrombocytopenia. | Chest 20060601 |
| Argatroban: update. | American heart journal 20060601 |
| [Pharmacotherapy: argatroban--alternative to heparin in case of heparin-induced thrombocytopenia type II (HIT II)]. | Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20060601 |
| [Advanced medical therapy in patients with acute ischemic stroke]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20060601 |
| Heparin-induced thrombocytopenia in a pediatric patient receiving extracorporeal support and treated with argatroban. | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20060501 |
| Argatroban dosing of patients with heparin-induced thrombocytopenia and an elevated aPTT due to antiphospholipid antibody syndrome. | The Annals of pharmacotherapy 20060501 |
| Argatroban therapy in heparin-induced thrombocytopenia with hepatic dysfunction. | Chest 20060501 |
| Thrombin-induced delayed injury involves multiple and distinct signaling pathways in the cerebral cortex and the striatum in organotypic slice cultures. | Neurobiology of disease 20060401 |
| [Argatroban: pharmacological properties and anaesthesiological aspects]. | Der Anaesthesist 20060401 |
| Evaluation of treatment with direct thrombin inhibitors in patients with heparin-induced thrombocytopenia. | Pharmacotherapy 20060401 |
| Inhibitors of blood coagulation factors Xa and IIa synergize to reduce thrombus weight and thrombin generation in vivo and in vitro. | Journal of thrombosis and haemostasis : JTH 20060401 |
| Argatroban: a direct thrombin inhibitor with reliable and predictable anticoagulant actions. | Drugs of today (Barcelona, Spain : 1998) 20060401 |
| Cardiac surgery in a patient with heparin-induced thrombocytopenia--cautions with use of the direct thrombin inhibitor, argatroban. | Connecticut medicine 20060401 |
| [Argatroban]. | Deutsche medizinische Wochenschrift (1946) 20060331 |
| Safety and efficacy of argatroban in patients with heparin-induced thrombocytopenia. | Current hematology reports 20060301 |
| A new method for assessment of an anti-5HT(2A) agent, sarpogrelate hydrochloride, on platelet aggregation. | Journal of thrombosis and haemostasis : JTH 20060201 |
| Treatment of heparin-induced thrombocytopenia in cardiovascular patients. | Expert opinion on pharmacotherapy 20060201 |
| Successful recovery after an overdose of argatroban. | The Annals of pharmacotherapy 20060201 |
| [A case of heparin-induced thrombocytopenia associated with unexpected excessive argatroban anticoagulation after abdominal aortic aneurysm resection]. | Masui. The Japanese journal of anesthesiology 20060201 |
| Antithrombin reduces reperfusion-induced hepatic metastasis of colon cancer cells. | World journal of gastroenterology 20060107 |
| Argatroban, a direct thrombin inhibitor for heparin-induced thrombocytopaenia: present and future perspectives. | Expert opinion on pharmacotherapy 20060101 |
| The cost-effectiveness of argatroban treatment in heparin-induced thrombocytopenia: the effect of early versus delayed treatment. | Cardiology in review 20060101 |
| Argatroban anticoagulation in pediatric patients: a literature analysis. | Journal of pediatric hematology/oncology 20060101 |
| Heparin-induced thrombocytopenia and cardiovascular patients: recognition and treatment. | Progress in cardiovascular nursing 20060101 |
| Argatroban for suspected heparin-induced thrombocytopenia: contemporary experience at a large teaching hospital. | Journal of intensive care medicine 20060101 |
| Heparin-induced thrombocytopenia in patients administered heparin solely for hemodialysis. | Renal failure 20060101 |
| Treatment of heparin-induced thrombocytopenia: a practical argatroban dosing protocol for nurses. | Journal of infusion nursing : the official publication of the Infusion Nurses Society 20060101 |
| Evaluation of diagnostic tests and argatroban or lepirudin therapy in patients with suspected heparin-induced thrombocytopenia. | Pharmacotherapy 20051201 |
| Heparin-induced thrombocytopenia from venous thromboembolism treatment. | Journal of internal medicine 20051201 |
| Comment: extensive prolongation of aPTT with argatroban in an elderly patient with improving renal function, normal hepatic enzymes, and metastatic lung cancer. | The Annals of pharmacotherapy 20051101 |
| Differences in the clinically effective molar concentrations of four direct thrombin inhibitors explain their variable prothrombin time prolongation. | Thrombosis and haemostasis 20051101 |
| Mechanism of antithrombotic effect of heparin and antithrombin in balloon-injured arteries. | Life sciences 20051007 |
| Argatroban-coupled Affi-Gel matrix for the purification of thrombin from plasma. | Biotechnology and applied biochemistry 20051001 |
| Argatroban anticoagulation in patients with heparin-induced thrombocytopenia requiring renal replacement therapy. | The Annals of pharmacotherapy 20051001 |
| Presence of direct thrombin inhibitors can affect the results and interpretation of lupus anticoagulant testing. | American journal of clinical pathology 20051001 |
| Argatroban and lepirudin requirements in a 6-year-old patient with heparin-induced thrombocytopenia. | Pharmacotherapy 20051001 |
| Argatroban and lepirudin: clinical trials to clinical practice. | Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20051001 |
| A comparison of lepirudin and argatroban outcomes. | Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20051001 |
| [A case of anterior cerebral artery dissection causing enlargement of infarction]. | Rinsho shinkeigaku = Clinical neurology 20051001 |
| Direct thrombin inhibitors. | The New England journal of medicine 20050908 |
| The role of thrombin in gliomas. | Journal of thrombosis and haemostasis : JTH 20050901 |
| Collaborative study on monitoring methods to determine direct thrombin inhibitors lepirudin and argatroban. | Journal of thrombosis and haemostasis : JTH 20050901 |
| Acute subdural hematoma: new model delineation and effects of coagulation inhibitors. | Neurosurgery 20050901 |
| Heparin and other rapidly acting anticoagulants. | Seminars in vascular surgery 20050901 |
| Cardiopulmonary bypass using argatroban as an anticoagulant for a 6.0-kg pediatric patient. | The journal of extra-corporeal technology 20050901 |
| Successful therapy with argatroban for superior mesenteric vein thrombosis in a patient with congenital antithrombin deficiency. | European journal of haematology 20050801 |
| Scanning electron microscopical observations of two novel hemostatic polymers. | Journal of thrombosis and haemostasis : JTH 20050701 |
| Thrombin inhibitor reduces leukocyte-endothelial cell interactions and vascular leakage after scatter laser photocoagulation. | Investigative ophthalmology & visual science 20050701 |
| Toxicity of argatroban overdose in a 65-year-old man. | American journal of hematology 20050701 |
| Transitioning from argatroban to warfarin therapy in patients with heparin-induced thrombocytopenia. | Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20050701 |
| [Heparin-induced thrombocytopenia (HIT): pathogenesis, laboratory test, and treatment]. | Rinsho byori. The Japanese journal of clinical pathology 20050701 |
| Evolving management strategies for heparin-induced thrombocytopenia. | Seminars in hematology 20050701 |
| Effect of argatroban on the activated partial thromboplastin time: a comparison of 21 commercial reagents. | Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20050601 |
| Extensive prolongation of aPTT with argatroban in an elderly patient with improving renal function, normal hepatic enzymes, and metastatic lung cancer. | The Annals of pharmacotherapy 20050601 |
| Direct thrombin inhibitors: pharmacology and clinical relevance. | Anaesthesia 20050601 |
| [Nontraumatic arterial dissection of the anterior cerebral artery: six cases report]. | No to shinkei = Brain and nerve 20050601 |
| Transitioning from argatroban to warfarin in heparin-induced thrombocytopenia: an analysis of outcomes in patients with elevated international normalized ratio (INR). | Journal of thrombosis and thrombolysis 20050601 |
| The paradox of heparin-induced thrombocytopenia: the initial management. | Orthopedics 20050601 |
| Carotid tissue levels of argatroban after direct local delivery during carotid endarterectomy to prevent perioperative cerebral embolism. | Neurosurgery 20050501 |
| No increase in rejection or graft loss in kidney transplant recipients with thrombophilia treated with anticoagulation and triple immunosuppression. | Transplantation proceedings 20050501 |
| The use of argatroban for carotid endarterectomy in heparin-induced thrombocytopenia. | Anesthesia and analgesia 20050401 |
| Argatroban for anticoagulation during cardiopulmonary bypass in an infant. | Paediatric anaesthesia 20050401 |
| An anesthesia provider's perspective of heparin-induced thrombocytopenia. | AANA journal 20050401 |
| Heparin-induced thrombocytopenia: principles for early recognition and management. | Cleveland Clinic journal of medicine 20050401 |
| Antithrombotic potential of new direct thrombin inhibitors built on the azaphenylalanine scaffold in two rat venous thrombosis models. | Thrombosis and haemostasis 20050301 |
| Coagulation management of a patient with factor V Leiden mutation, lupus anticoagulant, and activated protein C resistance: a case report. | Perfusion 20050301 |
| Argatroban and renal replacement therapy in patients with heparin-induced thrombocytopenia. | The Annals of pharmacotherapy 20050201 |
| Transition to an oral anticoagulant in patients with heparin-induced thrombocytopenia. | Chest 20050201 |
| Direct thrombin inhibitors in heparin-induced thrombocytopenia. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050201 |
| Use of the chromogenic factor X assay to predict the international normalized ratio in patients transitioning from argatroban to warfarin. | Pharmacotherapy 20050201 |
| Treatment of patients with a history of heparin-induced thrombocytopenia and anti-lepirudin antibodies with argatroban. | Journal of thrombosis and thrombolysis 20050201 |
| Spontaneous atrioventricular groove disruption during off-pump coronary artery bypass grafting. | The Annals of thoracic surgery 20050101 |
| Heparin-induced thrombocytopenia in the cardiovascular patient: diagnostic and treatment guidelines. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20050101 |
| Thrombin, an ideal target for pharmacological inhibition: a review of direct thrombin inhibitors. | American heart journal 20050101 |
| Thrombin-directed inhibitors: pharmacology and clinical use. | American heart journal 20050101 |
| Systemic administration of argatroban reduces secondary brain damage in a rat model of intracerebral hemorrhage: histopathological assessment. | Cerebrovascular diseases (Basel, Switzerland) 20050101 |
| Argatroban treatment for patients with intolerance to heparin and hirudin. | Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20050101 |
| Alternative parenteral anticoagulation with argatroban, a direct thrombin inhibitor. | Expert review of cardiovascular therapy 20050101 |
| Selective methodologies for the synthesis of biologically active piperidinic compounds. | Chemical record (New York, N.Y.) 20050101 |
| Heparin-induced thrombocytopenia. | Disease-a-month : DM 20050101 |
| Argatroban anticoagulation in patients with a history of heparin-induced thrombocytopenia. | Thrombosis research 20050101 |
| Clinical presentation and laboratory diagnosis of heparin-induced thrombocytopenia. | Seminars in thoracic and cardiovascular surgery 20050101 |
| Anticoagulant use in patients with chronic renal impairment. | American journal of cardiovascular drugs : drugs, devices, and other interventions 20050101 |
| Direct thrombin inhibitors are not equally effective in vivo against arterial thrombosis: in vivo evaluation of DuP714 and argatroban in a porcine angioplasty model and comparison to r-hirudin. | Thrombosis research 20050101 |
| New trends in anticoagulant treatments. | Lupus 20050101 |
| Thrombocytopenia following heparin flush. | Progress in cardiovascular nursing 20050101 |
| Inhibition of thrombin-induced vascular endothelial growth factor production in human neuroblastoma (NB-1) cells by argatroban. | Pathophysiology of haemostasis and thrombosis 20050101 |
| Systemic use of argatroban reduces tumor mass, attenuates neurological deficits and prolongs survival time in rat glioma models. | Acta neurochirurgica. Supplement 20050101 |
| Severe argatroban-induced coagulopathy in a patient with a history of heparin-induced thrombocytopenia. | The Annals of thoracic surgery 20041201 |
| Argatroban as a heparin substitute in cases of heparin-induced thrombocytopenia. | The Annals of thoracic surgery 20041201 |
| A prospective comparison of three argatroban treatment regimens during hemodialysis in end-stage renal disease. | Kidney international 20041201 |
| Current role of antithrombotic agents in the treatment of acute coronary syndromes. | Seminars in thrombosis and hemostasis 20041201 |
| Compatibility of argatroban with selected cardiovascular agents. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20041115 |
| [Clinical guidelines for stroke]. | Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20041110 |
| Heparin-induced thrombocytopenia: diagnosis and management. | Circulation 20041102 |
| The effects of argatroban on thrombin generation and hemostatic activation in vitro. | Anesthesia and analgesia 20041101 |
| Effects of pentasaccharide (fondaparinux) and direct thrombin inhibitors on coagulation testing. | Archives of pathology & laboratory medicine 20041001 |
| Monitoring direct thrombin inhibitors: time for standardization. | Anesthesiology 20041001 |
| Comparing direct thrombin inhibitors using aPTT, ecarin clotting times, and thrombin inhibitor management testing. | The Annals of pharmacotherapy 20040901 |
| Pharmacokinetics and pharmacodynamics of argatroban in combination with a platelet glycoprotein IIB/IIIA receptor antagonist in patients undergoing percutaneous coronary intervention. | Journal of clinical pharmacology 20040901 |
| [Use of argatroban as a substitute for heparin in a patient with suspected HIT type II undergoing carotid endarterectomy]. | Masui. The Japanese journal of anesthesiology 20040901 |
| [Prospective randomized study of argatroban versus heparin anticoagulation therapy after percutaneous coronary intervention for acute myocardial infarction]. | Journal of cardiology 20040801 |
| Argatroban anticoagulation in conjunction with glycoprotein IIb/IIIa inhibition in patients undergoing percutaneous coronary intervention: an open-label, nonrandomized pilot study. | Journal of thrombosis and thrombolysis 20040801 |
| [Prevention and treatment of deep vein thrombosis with ximelagatran]. | Deutsche medizinische Wochenschrift (1946) 20040723 |
| Ability of anti-glycoprotein IIb/IIIa agents to dissolve platelet thrombi formed on a collagen surface under blood flow conditions. | Journal of the American College of Cardiology 20040721 |
| Argatroban anticoagulation in patients with acute ischemic stroke (ARGIS-1): a randomized, placebo-controlled safety study. | Stroke 20040701 |
| Intraoperative management of a congenital antithrombin deficient patient on chronic hemodialysis. | Thrombosis and haemostasis 20040701 |
| Local delivery of argatroban for the prevention of restenosis after coronary balloon angioplasty: a prospective randomized pilot study. | Circulation journal : official journal of the Japanese Circulation Society 20040701 |
| Heparin-induced thrombocytopenia and thrombosis in a patient with polycythemia vera. | Internal medicine (Tokyo, Japan) 20040701 |
| Transition from argatroban to oral anticoagulation with phenprocoumon or acenocoumarol: effects on prothrombin time, activated partial thromboplastin time, and Ecarin Clotting Time. | Thrombosis and haemostasis 20040601 |
| Collagen-induced generation of platelet-derived microparticles in whole blood is dependent on ADP released from red blood cells and calcium ions. | Platelets 20040601 |
| [Heparin-induced thrombocytopenia in patients on hemodialysis]. | Nihon rinsho. Japanese journal of clinical medicine 20040601 |
| Direct thrombin inhibitors in the treatment of immune-mediated heparin-induced thrombocytopenia. | Seminars in thrombosis and hemostasis 20040601 |
| Percutaneous interventions in patients with immune-mediated heparin-induced thrombocytopenia. | Seminars in thrombosis and hemostasis 20040601 |
| Argatroban usage for anticoagulation for ECMO on a post-cardiac patient with heparin-induced thrombocytopenia. | The journal of extra-corporeal technology 20040601 |
| Heparinless cardiopulmonary bypass with argatroban in dogs. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20040501 |
| Argatroban therapy for antithrombin deficiency and mesenteric thrombosis: case report and review of the literature. | Pharmacotherapy 20040501 |
| [How to use anticoagulants in hemodialysis therapy]. | Nihon rinsho. Japanese journal of clinical medicine 20040501 |
| [Anticoagulant]. | Nihon rinsho. Japanese journal of clinical medicine 20040501 |
| Stroke in patients with heparin-induced thrombocytopenia and the effect of argatroban therapy. | Critical care medicine 20040401 |
| Effect of direct thrombin inhibitors, bivalirudin, lepirudin, and argatroban, on prothrombin time and INR values. | American journal of clinical pathology 20040401 |
| Synthetic selective inhibitors of coagulation factor Xa strongly inhibit thrombin generation without affecting initial thrombin forming time necessary for platelet activation in hemostasis. | Journal of thrombosis and haemostasis : JTH 20040401 |
| Acute ischemic stroke successfully treated using sequenced intravenous and intra-arterial thrombolysis and argatroban anticoagulation: a case study. | Journal of thrombosis and thrombolysis 20040401 |
| Developing an algorithm for treating heparin-induced thrombocytopenia. | Clinical advances in hematology & oncology : H&O 20040401 |
| Antithrombotic effects of FK419, a novel nonpeptide platelet GPIIb/IIIa antagonist, in a guinea pig photochemically induced middle cerebral artery thrombosis model: comparison with ozagrel and argatroban. | The Journal of pharmacology and experimental therapeutics 20040301 |
| Argatroban dosing in intensive care patients with acute renal failure and liver dysfunction. | Pharmacotherapy 20040301 |
| Small-molecule direct antithrombins: argatroban. | Best practice & research. Clinical haematology 20040301 |
| Treatment of heparin-induced thrombocytopenia: a critical review. | Archives of internal medicine 20040223 |
| Argatroban as anticoagulant in cardiopulmonary bypass in an infant and attempted reversal with recombinant activated factor VII. | Anesthesiology 20040201 |
| Failure of argatroban anticoagulation during off-pump coronary artery bypass surgery. | The Annals of thoracic surgery 20040201 |
| Argatroban use during pediatric interventional cardiac catheterization. | Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20040101 |
| Influence of conduction disturbances on clinical outcome in patients with acute myocardial infarction receiving thrombolysis (results from the ARGAMI-2 study). | The American journal of cardiology 20040101 |
| Argatroban use in dialysis patients. | Seminars in dialysis 20040101 |
| Effect of renal function on the pharmacodynamics of argatroban. | The Annals of pharmacotherapy 20040101 |
| Direct thrombin inhibitors. | Clinical laboratory science : journal of the American Society for Medical Technology 20040101 |
| Argatroban as an alternative to heparin in extracorporeal membrane oxygenation circuits. | Perfusion 20040101 |
| Thrombin inhibitor, argatroban, prevents tumor cell migration and bone metastasis. | Oncology 20040101 |
| Alternatives to heparin infusion. | Journal of infusion nursing : the official publication of the Infusion Nurses Society 20040101 |
| Argatroban, a new treatment option for heparin-induced thrombocytopenia. | Critical care nurse 20031201 |
| Predictive value of serial platelet count and VEGF determination for the management of DIC in the Crow-Fukase (POEMS) syndrome. | Internal medicine (Tokyo, Japan) 20031201 |
| Treatment options for heparin-induced thrombocytopenia. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20031015 |
| Argatroban for off-pump coronary artery bypass surgery. | Anesthesia and analgesia 20031001 |
| Direct thrombin inhibitors for non-ST-segment elevation acute coronary syndromes: what, when, and where? | American heart journal 20031001 |
| Vascular surgery using argatroban in a patient with a history of heparin-induced thrombocytopenia. | Circulation journal : official journal of the Japanese Circulation Society 20031001 |
| Differential effects of DX-9065a, argatroban, and synthetic pentasaccharide on tissue thromboplastin inhibition test and dilute Russell's viper venom test. | Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20031001 |
| Argatroban for heparin-induced thrombocytopenia in hepato-renal failure and CVVHD. | The Annals of pharmacotherapy 20030901 |
| Decreased argatroban clearance unaffected by hemodialysis in anasarca. | The Annals of pharmacotherapy 20030901 |
| Antithrombotic properties of a direct thrombin inhibitor with a prolonged half-life and AT-mediated factor Xa inhibitory activity. | Journal of thrombosis and haemostasis : JTH 20030901 |
| Argatroban inhibits staphylothrombin. | Journal of thrombosis and haemostasis : JTH 20030901 |
| Argatroban attenuates leukocyte- and platelet-endothelial cell interactions after transient retinal ischemia. | Stroke 20030801 |
| Effects of argatroban as an anticoagulant for haemodialysis in patients with antithrombin III deficiency. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20030801 |
| Argatroban anticoagulation in patients with heparin-induced thrombocytopenia. | Archives of internal medicine 20030801 |
| Pharmacologic platelet anesthesia by glycoprotein IIb/IIIa complex antagonist and argatroban during in vitro extracorporeal circulation. | The Journal of thoracic and cardiovascular surgery 20030801 |
| Inhibition of arterial thrombosis by a protease-activated receptor 1 antagonist, FR171113, in the guinea pig. | European journal of pharmacology 20030725 |
| Obstinate thrombosis during percutaneous coronary intervention in a case with heparin-induced thrombocytopenia with thrombosis syndrome successfully treated by argatroban anticoagulant therapy. | Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20030701 |
| Direct thrombin inhibitors during PCI. | Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20030701 |
| Heparin-induced thrombocytopenia--recognition and treatment. | AORN journal 20030701 |
| Ecarin chromogenic assay--a new method for quantitative determination of direct thrombin inhibitors like hirudin. | Pathophysiology of haemostasis and thrombosis 20030701 |
| The thrombin inhibitor argatroban does not influence the endothelium-dependent relaxant and contractile responses of isolated rabbit carotid arteries. | Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20030601 |
| Excessive argatroban anticoagulation for heparin-induced thrombocytopenia. | The Annals of pharmacotherapy 20030501 |
| Suppression of argatroban-induced endogenous thrombolysis by PKSI-527, and antibodies to TPA and UPA, evaluated in a rat arterial thrombolysis model. | Thrombosis and haemostasis 20030501 |
| Successful use of Argatroban as a heparin substitute during cardiopulmonary bypass: heparin-induced thrombocytopenia in a high-risk cardiac surgical patient. | The Annals of thoracic surgery 20030501 |
| Direct thrombin inhibitors. | Expert opinion on pharmacotherapy 20030501 |
| Predicting the pharmacology of thrombin inhibitors. | Journal of thrombosis and haemostasis : JTH 20030501 |
| Management of heparin-induced thrombocytopenia: a critical comparison of lepirudin and argatroban. | Thrombosis research 20030501 |
| Hemostatic analysis of a patient undergoing off-pump coronary artery bypass surgery with argatroban anticoagulation. | Anesthesia and analgesia 20030401 |
| Anticoagulation in acute cardiac care in patients with chronic kidney disease. | American heart journal 20030401 |
| Argatroban as an alternative anticoagulant for patients with heparin allergy during coronary bypass surgery. | Heart and vessels 20030301 |
| Argatroban, specific thrombin inhibitor, induced phenotype change of cultured rabbit vascular smooth muscle cells. | European journal of pharmacology 20030207 |
| Heparin-induced thrombocytopenia and cardiopulmonary bypass: perioperative argatroban use. | The Annals of thoracic surgery 20030201 |
| Characteristics of the hemostatic action of KFA-1411, an inhibitor of coagulation factor Xa (FXa), in humans and various animals. | The Journal of toxicological sciences 20030201 |
| Clinician update: direct thrombin inhibitors in acute coronary syndromes. | Journal of thrombosis and thrombolysis 20030201 |
| Acute pulmonary thromboembolism induced by prophylactic heparin use and a heparin-coated catheter: a case of heparin-induced thrombocytopenia and thrombosis syndrome. | Circulation journal : official journal of the Japanese Circulation Society 20030101 |
| Alternative methods of anticoagulation for dialysis-dependent patients with heparin-induced thrombocytopenia. | Seminars in dialysis 20030101 |
| Direct thrombin inhibitors in cardiac disease. | Cardiovascular toxicology 20030101 |
| Effects of argatroban and heparin on thrombus formation and tissue plasminogen activator-induced thrombolysis in a microvascular thrombosis model. | Thrombosis research 20030101 |
| Argatroban dosing in patients with heparin-induced thrombocytopenia. | The Annals of pharmacotherapy 20030101 |
| Mild hypothermia enhances the neuroprotective effects of a selective thrombin inhibitor following transient focal ischemia in rats. | Acta neurochirurgica. Supplement 20030101 |
| Effect of delayed argatroban treatment on intracerebral hemorrhage-induced edema in the rat. | Acta neurochirurgica. Supplement 20030101 |
| A thrombin inhibitor reduces brain edema, glioma mass and neurological deficits in a rat glioma model. | Acta neurochirurgica. Supplement 20030101 |
| The effect of dietary bacillus natto productive protein on in vivo endogenous thrombolysis. | Pathophysiology of haemostasis and thrombosis 20030101 |
| Studies on the different modes of action of the anticoagulant protease inhibitors DX-9065a and Argatroban. II. Effects on fibrinolysis. | The Journal of biological chemistry 20021227 |
| Studies on the different modes of action of the anticoagulant protease inhibitors DX-9065a and Argatroban. I. Effects on thrombin generation. | The Journal of biological chemistry 20021227 |
| Thrombosis increases circulatory hepatocyte growth factor by degranulation of mast cells. | Circulation 20021210 |
| Delayed argatroban treatment reduces edema in a rat model of intracerebral hemorrhage. | Stroke 20021201 |
| Argatroban in adult extracorporeal membrane oxygenation. | The journal of extra-corporeal technology 20021201 |
| Lack of pharmacokinetic interactions between argatroban and warfarin. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20021101 |
| Low-molecular weight heparin: treatment failure in a patient with primary antiphospholipid antibody syndrome. | The American journal of the medical sciences 20021101 |
| Influence of lepirudin, argatroban, and melagatran on prothrombin time and additional effect of oral anticoagulation. | Clinical chemistry 20021001 |
| Argatroban anticoagulation during percutaneous coronary intervention in patients with heparin-induced thrombocytopenia. | Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20021001 |
| Argatroban for percutaneous coronary interventions: hit or miss? | Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20021001 |
| Hirudin in heparin-induced thrombocytopenia. | Seminars in thrombosis and hemostasis 20021001 |
| Visual compatibility of argatroban with selected drugs. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20020915 |
| Current agents for the treatment of patients with heparin-induced thrombocytopenia. | Current opinion in pulmonary medicine 20020901 |
| Comment: treatment of heparin-induced thrombocytopenia. | The Annals of pharmacotherapy 20020901 |
| Venous limb gangrene during overlapping therapy with warfarin and a direct thrombin inhibitor for immune heparin-induced thrombocytopenia. | American journal of hematology 20020901 |
| Preventing complications in heparin-induced thrombocytopenia. Alternative anticoagulants are improving patient outcomes. | Postgraduate medicine 20020901 |
| Antithrombotic drugs for the treatment of heparin-induced thrombocytopenia. | Current opinion in investigational drugs (London, England : 2000) 20020801 |
| [Experimental and clinical results with the thrombin inhibitor Argatroban]. | Hamostaseologie 20020801 |
| Monitoring of anticoagulant effects of direct thrombin inhibitors. | Seminars in thrombosis and hemostasis 20020801 |
| Investigation of the interaction between argatroban and acetaminophen, lidocaine, or digoxin. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20020701 |
| Monitoring of argatroban in ARG310 study: potential recommendations for its use in interventional cardiology. | Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20020701 |
| Direct antithrombin agents ameliorate disseminated intravascular coagulation in suspected heparin-induced thrombocytopenia thrombosis syndrome. | Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20020701 |
| The role of thrombin inhibition during percutaneous coronary intervention. | Pharmacotherapy 20020601 |
| [Heparin-induced thrombocytopenia: the clinical picture and treatment]. | [Rinsho ketsueki] The Japanese journal of clinical hematology 20020601 |
| Anticoagulant therapy with a selective thrombin inhibitor for acute cerebral infarction: usefulness of coagulation markers for evaluation of efficacy. | Journal of thrombosis and thrombolysis 20020601 |
| Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils. | Neuroscience research 20020501 |
| Long-term inhibition of nitric oxide synthesis increases arterial thrombogenecity in rat carotid artery. | American journal of physiology. Heart and circulatory physiology 20020401 |
| Direct thrombin inhibitors for percutaneous coronary intervention in the current era of platelet glycoprotein IIb/IIIa inhibition. | Journal of interventional cardiology 20020401 |
| Treatment of heparin-induced thrombocytopenia. | The Annals of pharmacotherapy 20020301 |
| Argatroban therapy does not generate antibodies that alter its anticoagulant activity in patients with heparin-induced thrombocytopenia. | Thrombosis research 20020301 |
| Inhibitors of fibrinolytic components play different roles in the formation and removal of arterial thrombus in mice. | Journal of cardiovascular pharmacology 20020201 |
| Platelet shape changes and adhesion under high shear flow. | Arteriosclerosis, thrombosis, and vascular biology 20020201 |
| Substitution of Gly-548 to Ala in the substrate binding pocket of prothrombin Perijá leads to the loss of thrombin proteolytic activity. | Thrombosis and haemostasis 20020201 |
| An antibody that binds to primary specific pocket-associated structure in the active site of bovine thrombin. | Hybridoma and hybridomics 20020201 |
| Argatroban. | Journal of thrombosis and thrombolysis 20020201 |
| Direct thrombin inhibitors in acute coronary syndromes: principal results of a meta-analysis based on individual patients' data. | Lancet (London, England) 20020126 |
| [Intraoperative management for a patient with heparin-induced thrombocytopenia (HIT) undergoing off-pump coronary bypass surgery using argatroban, a direct thrombin inhibitor]. | Masui. The Japanese journal of anesthesiology 20020101 |
| Enhancement of endogenous plasminogen activator-induced thrombolysis by argatroban and APC and its control by TAFI, measured in an arterial thrombolysis model in vivo using rat mesenteric arterioles. | Thrombosis and haemostasis 20020101 |
| Therapeutic considerations in the management of patients with heparin-induced thrombocytopenia. | Progress in cardiovascular nursing 20020101 |
| Role of thrombin in CNS damage associated with intracerebral haemorrhage: opportunity for pharmacological intervention? | CNS drugs 20020101 |
| Effect of phenprocoumon on monitoring of lepirudin, argatroban, melagatran and unfractionated heparin with the PiCT method. | Pathophysiology of haemostasis and thrombosis 20020101 |
| An overview of the direct thrombin inhibitor argatroban. | Pathophysiology of haemostasis and thrombosis 20020101 |
| Development of argatroban as an anticoagulant and antithrombin agent in Japan. | Pathophysiology of haemostasis and thrombosis 20020101 |
| Argatroban in thrombotic stroke. | Pathophysiology of haemostasis and thrombosis 20020101 |
| Argatroban in HIT type II and acute coronary syndrome. | Pathophysiology of haemostasis and thrombosis 20020101 |
| Practical issues in the development of argatroban: a perspective. | Pathophysiology of haemostasis and thrombosis 20020101 |
| The use of argatroban as an anticoagulant for cardiopulmonary bypass in cardiac operations. | The Journal of thoracic and cardiovascular surgery 20011201 |
| Changes in blood viscosity by heparin and argatroban. | Thrombosis research 20011201 |
| The antithrombotic efficacy of AT-1459, a novel, direct thrombin inhibitor, in rat models of venous and arterial thrombosis. | Thrombosis and haemostasis 20011201 |
| Successful use of argatroban as an anticoagulant in burn-related severe acquired antithrombin III deficiency after heparin failure. | Thrombosis and haemostasis 20011201 |
| [Strategy for circulatory disturbance]. | Rinsho shinkeigaku = Clinical neurology 20011201 |
| Extension of the therapeutic window for recombinant tissue plasminogen activator with argatroban in a rat model of embolic stroke. | Stroke 20011101 |
| Anticoagulation with a selective thrombin inhibitor in a woman with heparin-induced thrombocytopenia. | Obstetrics and gynecology 20011101 |
| Argatroban. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20011101 |
| A synopsis of the clinical uses of argatroban. | Journal of thrombosis and thrombolysis 20011001 |
| Alternatives to unfractionated heparin for anticoagulation in cardiopulmonary bypass. | Perfusion 20010901 |
| A short synthesis of argatroban. a potent selective thrombin inhibitor. | Bioorganic & medicinal chemistry letters 20010806 |
| Thrombin promotes fibroblast proliferation during the early stages of experimental radiation pneumonitis. | Radiation research 20010701 |
| Broad-spectrum and selective serine protease inhibitors prevent expression of platelet-derived growth factor-BB and cerebral vasospasm after subarachnoid hemorrhage: vasospasm caused by cisternal injection of recombinant platelet-derived growth factor-BB. | Stroke 20010701 |
| Anticoagulation: the present and future. | Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20010701 |
| Thrombin inhibition attenuates neurodegeneration and cerebral edema formation following transient forebrain ischemia. | Brain research 20010601 |
| Direct thrombin inhibitors: are they the future of anticoagulation? | South Dakota journal of medicine 20010601 |
| Advances in the development of thrombin inhibitors. | Expert opinion on investigational drugs 20010501 |
| Argatroban anticoagulant therapy in patients with heparin-induced thrombocytopenia. | Circulation 20010410 |
| Argatroban for prevention and treatment of thromboembolism in heparin-induced thrombocytopenia. | The Annals of pharmacotherapy 20010401 |
| Heparin induced thrombocytopenia thrombosis (HIT/T) syndrome: diagnosis and treatment. | Journal of clinical pathology 20010401 |
| [Direct thrombin antagonists]. | Herz 20010401 |
| Off-pump coronary artery bypass for a heparin-allergic patient. | The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi 20010401 |
| A specific thrombin inhibitor, argatroban, alleviates herpes zoster-associated pain. | The Journal of dermatology 20010401 |
| Interpreting the International Normalized Ratio (INR) in individuals receiving argatroban and warfarin. | Thrombosis and haemostasis 20010301 |
| Argatroban for treatment of heparin-induced thrombocytopenia. | The Medical letter on drugs and therapeutics 20010205 |
| Antithrombotic effects of a synthetic inhibitor of activated factor X, JTV-803, in animals. | European journal of pharmacology 20010119 |
| [Specific inhibition of thrombin activity during cardiopulmonary bypass reduces ischemia-reperfusion injury of the lung]. | Fukuoka igaku zasshi = Hukuoka acta medica 20010101 |
| Argatroban. | Drugs 20010101 |
| Enhanced thrombolysis induced by argatroban or activated protein C in the presence or absence of staphylokinase, measured in an in vivo animal model using mesenteric arterioles. | Haemostasis 20010101 |
| Argatroban: a direct thrombin inhibitor for heparin-induced thrombocytopenia and other clinical applications. | Heart disease (Hagerstown, Md.) 20010101 |
| In vitro antiplatelet profile of FR171113, a novel non-peptide thrombin receptor antagonist. | European journal of pharmacology 19991119 |
| Pharmacological effects of a novel recombinant hirudin, CX-397, in vivo and in vitro: comparison with recombinant hirudin variant-1, heparin, and argatroban. | Thrombosis and haemostasis 19990201 |
| The first report of successful carotid stent implant using argatroban anticoagulation in a patient with heparin-induced thrombocytopenia and thrombosis syndrome: a case report. | Angiology 19980101 |
| Inhibition of collagen-induced platelet aggregation by argatroban in patients with acute cerebral infarction. | Thrombosis research 19971015 |
| Anticoagulation with Novastan (argatroban) in patients with heparin-induced thrombocytopenia and heparin-induced thrombocytopenia and thrombosis syndrome. | Seminars in thrombosis and hemostasis 19970101 |
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