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14009-24-6 | 1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline
CAS No: 14009-24-6 Catalog No: AG01BJE1 MDL No:MFCD01543445
Product Description
Catalog Number:
AG01BJE1
Chemical Name:
1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline
CAS Number:
14009-24-6
MDL Number:
MFCD01543445
IUPAC Name:
(1Z)-1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3,4-dihydro-2H-isoquinoline
InChI:
InChI=1S/C24H31NO4/c1-5-26-21-10-9-17(14-22(21)27-6-2)13-20-19-16-24(29-8-4)23(28-7-3)15-18(19)11-12-25-20/h9-10,13-16,25H,5-8,11-12H2,1-4H3/b20-13-
InChI Key:
OMFNSKIUKYOYRG-MOSHPQCFSA-N
UNII:
98QS4N58TW
Properties
Complexity:
511
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
1
Exact Mass:
397.225g/mol
Formal Charge:
0
Heavy Atom Count:
29
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
397.515g/mol
Monoisotopic Mass:
397.225g/mol
Rotatable Bond Count:
9
Topological Polar Surface Area:
49A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
5.4
Literature
| Title | Journal |
|---|---|
| Biodegradation of drotaverine hydrochloride by free and immobilized cells of Rhodococcus rhodochrous IEGM 608. | World journal of microbiology & biotechnology 20121001 |
| Simultaneous determination of diclofenac potassium and drotaverine hydrochloride in human plasma using reversed-phase high-performance liquid chromatography. | Journal of chromatographic science 20120901 |
| Intramuscular drotaverine and diclofenac in acute renal colic: a comparative study of analgesic efficacy and safety. | Pain medicine (Malden, Mass.) 20120301 |
| Effects of drotaverine hydrochloride on viability of rat cultured cerebellar granulocytes. | Bulletin of experimental biology and medicine 20120201 |
| [Influence of Perftoran nanoemulsion on blood plasma concentrations of lipophilic drugs]. | Eksperimental'naia i klinicheskaia farmakologiia 20120101 |
| Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. | Toxicological sciences : an official journal of the Society of Toxicology 20101201 |
| Efficacy and safety of aceclofenac and drotaverine fixed-dose combination in the treatment of primary dysmenorrhoea: a double-blind, double-dummy, randomized comparative study with aceclofenac. | European journal of obstetrics, gynecology, and reproductive biology 20100901 |
| A randomised controlled study comparing Drotaverine hydrochloride and Valethamate bromide in the augmentation of labour. | Archives of gynecology and obstetrics 20100701 |
| Validation and application of chemometrics-assisted spectrophotometry and liquid chromatography for simultaneous determination of two ternary mixtures containing drotaverine hydrochloride. | Journal of AOAC International 20100101 |
| Effect of elevated intra-abdominal pressure on the contractile activity and reactivity of smooth muscle tissue from rat gastrointestinal tract to galantamine and drotaverine (No-Spa). | Folia medica 20100101 |
| Comparison of efficacy of oral drotaverine plus mefenamic acid with paracervical block and with intravenous sedation for pain relief during hysteroscopy and endometrial biopsy. | Indian journal of medical sciences 20090601 |
| Interactions between symptoms and motor and visceral sensory responses of irritable bowel syndrome patients to spasmolytics (antispasmodics). | Journal of gastrointestinal and liver diseases : JGLD 20090301 |
| Drotaverine hydrochloride versus hyoscine-N-butylbromide in augmentation of labor. | International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20080301 |
| Simultaneous determination of nifuroxazide and drotaverine hydrochloride in pharmaceutical preparations by bivariate and multivariate spectral analysis. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080201 |
| In vitro antioxidant properties of pentoxifylline and vinpocetine in a rheological model. | Clinical hemorheology and microcirculation 20080101 |
| [Comparative efficacy and tolerability of drotaverine 80 mg and ibuprofen 400 mg in patients with primary dysmenorrhoea--protocol DOROTA]. | Ginekologia polska 20071201 |
| Study of drotaverine on first stage of labour and pregnancy outcome. | Journal of the Indian Medical Association 20070801 |
| Spectrophotometric determination of pipazethate HCl, dextromethorphan HBr and drotaverine HCl in their pharmaceutical preparations. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20070701 |
| Spectrophotometric and spectrodensitometric determination of paracetamol and drotaverine HCl in combination. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20070401 |
| Application of derivative, derivative ratio, and multivariate spectral analysis and thin-layer chomatography-densitometry for determination of a ternary mixture containing drotaverine hydrochloride, caffeine, and paracetamol. | Journal of AOAC International 20070101 |
| Hemorheological efficiency of drugs, targeting on intracellular phosphodiesterase activity: in vitro study. | Clinical hemorheology and microcirculation 20070101 |
| No-Spa and Remantadin are the novel complex preparations that inhibit effectively reproduction of the avian influenza viruses. | Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20070101 |
| [Vegetotropic therapy and hypobaric hypoxic adaptation in gallbladder motor dysmotility]. | Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20070101 |
| [Dynamics of indices of visceral sensitivity in patients with irritable bowel syndrome treated with spasmolytics]. | Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20070101 |
| Application of new membrane selective electrodes for the determination of drotaverine hydrochloride in tablets and plasma. | Journal of pharmaceutical and biomedical analysis 20060607 |
| A comparative study on various spectrometries with thin layer chromatography for simultaneous analysis of drotaverine and nifuroxazide in capsules. | Chemical & pharmaceutical bulletin 20060601 |
| [Acute intermittent porphyria and oral contraception. Case report]. | Ginekologia polska 20060301 |
| Determination of nifuroxazide and drotaverine hydrochloride in pharmaceutical preparations by three independent analytical methods. | Journal of AOAC International 20060101 |
| Transport properties and electroanalytical response characteristics of drotaverine ion-selective sensors. | Analytical and bioanalytical chemistry 20050801 |
| [Using prostaglandin inhibitor dicloberl in patients with ureteral calculi]. | Likars'ka sprava 20040301 |
| Drotaverine hydrochloride for augmentation of labor. | International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20040101 |
| Bioavailability study of drotaverine from capsule and tablet preparations in healthy volunteers. | Arzneimittel-Forschung 20040101 |
| [New approaches to diagnosing and treating hyperkinetic biliary dyskinesia associated with chronic acalculous cholecystitis]. | Klinicheskaia meditsina 20040101 |
| The effect of drotaverine hydrochloride in acute colicky pain caused by renal and ureteric stones. | BJU international 20030701 |
| Drotaverine interacts with the L-type Ca(2+) channel in pregnant rat uterine membranes. | European journal of pharmacology 20020802 |
| [Safety profile of NO-SPA]. | Orvosi hetilap 20020317 |
| Drotaverine hydrochloride vs. valethamate bromide in acceleration of labor. | International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20010901 |
| Role of the enteric nervous plexus in rectal motile activity: an experimental study. | Journal of investigative surgery : the official journal of the Academy of Surgical Research 20010101 |
| Pharmacokinetics and bioavailability of drotaverine in humans. | European journal of drug metabolism and pharmacokinetics 19960101 |
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