200,000+ products from a single source!
sales@angenechem.com
Home > Sulfanilamide > 139308-65-9
139308-65-9 | Benzenesulfonamide, N-[4-[(4aR,10bS)-1,2,3,4,4a,10b-hexahydro-8,9-dimethoxy-2-methylbenzo[c][1,6]naphthyridin-6-yl]phenyl]-4-methyl-, rel-(-)-
CAS No: 139308-65-9 Catalog No: AG001AQ2 MDL No:
Product Description
Catalog Number:
AG001AQ2
Chemical Name:
Benzenesulfonamide, N-[4-[(4aR,10bS)-1,2,3,4,4a,10b-hexahydro-8,9-dimethoxy-2-methylbenzo[c][1,6]naphthyridin-6-yl]phenyl]-4-methyl-, rel-(-)-
CAS Number:
139308-65-9
Molecular Formula:
C28H31N3O4S
Molecular Weight:
505.6284
IUPAC Name:
N-[4-[(4aS,10bR)-8,9-dimethoxy-2-methyl-3,4,4a,10b-tetrahydro-1H-benzo[c][1,6]naphthyridin-6-yl]phenyl]-4-methylbenzenesulfonamide
InChI:
InChI=1S/C28H31N3O4S/c1-18-5-11-21(12-6-18)36(32,33)30-20-9-7-19(8-10-20)28-23-16-27(35-4)26(34-3)15-22(23)24-17-31(2)14-13-25(24)29-28/h5-12,15-16,24-25,30H,13-14,17H2,1-4H3/t24-,25-/m0/s1
InChI Key:
FVZJIAUYFDQQKJ-DQEYMECFSA-N
SMILES:
COc1cc2[C@H]3CN(C)CC[C@H]3N=C(c2cc1OC)c1ccc(cc1)NS(=O)(=O)c1ccc(cc1)C
Properties
Complexity:
874
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
2
Defined Bond Stereocenter Count:
0
Exact Mass:
505.204g/mol
Formal Charge:
0
Heavy Atom Count:
36
Hydrogen Bond Acceptor Count:
7
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
505.633g/mol
Monoisotopic Mass:
505.204g/mol
Rotatable Bond Count:
6
Topological Polar Surface Area:
88.6A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.1
Literature
| Title | Journal |
|---|---|
| cAMP phosphodiesterase inhibitors increases nitric oxide production by modulating dimethylarginine dimethylaminohydrolases. | Circulation 20110322 |
| Targeting dimethylarginine dimethylaminohydrolases in pulmonary arterial hypertension: a new approach to improve vascular dysfunction? | Circulation 20110322 |
| Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration. | Respiratory research 20050101 |
| Antiremodeling effects of iloprost and the dual-selective phosphodiesterase 3/4 inhibitor tolafentrine in chronic experimental pulmonary hypertension. | Circulation research 20040430 |
| Cyclic AMP increases endogenous granulocyte colony-stimulating factor formation in monocytes and THP-1 macrophages despite attenuated TNF-alpha formation. | European journal of immunology 20030801 |
| Amplification of the pulmonary vasodilatory response to inhaled iloprost by subthreshold phosphodiesterase types 3 and 4 inhibition in severe pulmonary hypertension. | Critical care medicine 20021101 |
| Coaerosolization of phosphodiesterase inhibitors markedly enhances the pulmonary vasodilatory response to inhaled iloprost in experimental pulmonary hypertension. Maintenance of lung selectivity. | American journal of respiratory and critical care medicine 20011101 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.