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Home > Fluorides > 139290-65-6
139290-65-6 | 4-Piperidinemethanol, α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-, (αR)-
CAS No: 139290-65-6 Catalog No: AG001AP3 MDL No:
Product Description
Catalog Number:
AG001AP3
Chemical Name:
4-Piperidinemethanol, α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-, (αR)-
CAS Number:
139290-65-6
Molecular Formula:
C22H28FNO3
Molecular Weight:
373.4610
IUPAC Name:
(R)-(2,3-dimethoxyphenyl)-[1-[2-(4-fluorophenyl)ethyl]piperidin-4-yl]methanol
InChI:
InChI=1S/C22H28FNO3/c1-26-20-5-3-4-19(22(20)27-2)21(25)17-11-14-24(15-12-17)13-10-16-6-8-18(23)9-7-16/h3-9,17,21,25H,10-15H2,1-2H3/t21-/m1/s1
InChI Key:
HXTGXYRHXAGCFP-OAQYLSRUSA-N
SMILES:
COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O
UNII:
EW71EE171J
Properties
Complexity:
422
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
1
Defined Bond Stereocenter Count:
0
Exact Mass:
373.205g/mol
Formal Charge:
0
Heavy Atom Count:
27
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
373.468g/mol
Monoisotopic Mass:
373.205g/mol
Rotatable Bond Count:
7
Topological Polar Surface Area:
41.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.9
Literature
| Title | Journal |
|---|---|
| Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays. | Chemical research in toxicology 20130617 |
| 5-HT(2A) receptor blockade and 5-HT(2C) receptor activation interact to reduce cocaine hyperlocomotion and Fos protein expression in the caudate-putamen. | Synapse (New York, N.Y.) 20121201 |
| 5-HT2A receptors in the orbitofrontal cortex facilitate reversal learning and contribute to the beneficial cognitive effects of chronic citalopram treatment in rats. | The international journal of neuropsychopharmacology 20121001 |
| Involvement of 5-HT2A receptor and α2-adrenoceptor blockade in the asenapine-induced elevation of prefrontal cortical monoamine outflow. | Synapse (New York, N.Y.) 20120701 |
| Effects of the 5-HT2C receptor agonist Ro60-0175 and the 5-HT2A receptor antagonist M100907 on nicotine self-administration and reinstatement. | Neuropharmacology 20120601 |
| Sustained recreational use of ecstasy is associated with altered pre and postsynaptic markers of serotonin transmission in neocortical areas: a PET study with [¹¹C]DASB and [¹¹C]MDL 100907. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120501 |
| Effects of the selective 5-HT(7) receptor antagonist SB-269970 in animal models of psychosis and cognition. | Behavioural brain research 20120301 |
| The neuropharmacology of prolactin secretion elicited by 3,4-methylenedioxymethamphetamine ('ecstasy'): a concurrent microdialysis and plasma analysis study. | Hormones and behavior 20120201 |
| 5-HT2A receptor antagonist M100907 reduces serotonin synthesis: an autoradiographic study. | Brain research bulletin 20120104 |
| Extended characterisation of the serotonin 2A (5-HT2A) receptor-selective PET radiotracer 11C-MDL100907 in humans: quantitative analysis, test-retest reproducibility, and vulnerability to endogenous 5-HT tone. | NeuroImage 20120102 |
| Dorsal-striatal 5-HT₂A and 5-HT₂C receptors control impulsivity and perseverative responding in the 5-choice serial reaction time task. | Psychopharmacology 20120101 |
| The 5-HT(2A) receptor and serotonin transporter in Asperger's disorder: A PET study with [¹¹C]MDL 100907 and [¹¹C]DASB. | Psychiatry research 20111230 |
| Serotonin 2A receptors in obsessive-compulsive disorder: a positron emission tomography study with [11C]MDL 100907. | Biological psychiatry 20111101 |
| p-Hydroxyamphetamine causes prepulse inhibition disruption in mice: contribution of serotonin neurotransmission. | Behavioural brain research 20111010 |
| Pimavanserin, a 5-HT2A inverse agonist, reverses psychosis-like behaviors in a rodent model of Parkinson's disease. | Behavioural pharmacology 20111001 |
| Impulsive action induced by amphetamine, cocaine and MK801 is reduced by 5-HT(2C) receptor stimulation and 5-HT(2A) receptor blockade. | Neuropharmacology 20110901 |
| Serotonin 2A receptor antagonists for treatment of schizophrenia. | Expert opinion on investigational drugs 20110901 |
| Serotonin control of sleep-wake behavior. | Sleep medicine reviews 20110801 |
| Effects of 5-HT(2A) and 5-HT(2C) receptor antagonists on acute and chronic dyskinetic effects induced by haloperidol in rats. | Behavioural brain research 20110601 |
| Serotonin (5-hydroxytryptamine) 5-HT(2A) receptor: association with inherent and cocaine-evoked behavioral disinhibition in rats. | Behavioural pharmacology 20110601 |
| Effects of direct- and indirect-acting serotonin receptor agonists on the antinociceptive and discriminative stimulus effects of morphine in rhesus monkeys. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20110401 |
| Blockade of nucleus accumbens 5-HT2A and 5-HT2C receptors prevents the expression of cocaine-induced behavioral and neurochemical sensitization in rats. | Psychopharmacology 20110201 |
| Blockade of 5-HT2A receptors in the medial prefrontal cortex attenuates reinstatement of cue-elicited cocaine-seeking behavior in rats. | Psychopharmacology 20110201 |
| P-glycoprotein influence on the brain uptake of a 5-HT(2A) ligand: [(18)F]MH.MZ. | Neuropsychobiology 20110101 |
| Possible involvement of serotonin 5-HT2 receptor in the regulation of feeding behavior through the histaminergic system. | Neuropharmacology 20110101 |
| Interaction of 5-HT2A and 5-HT2C receptors in R(-)-2,5-dimethoxy-4-iodoamphetamine-elicited head twitch behavior in mice. | The Journal of pharmacology and experimental therapeutics 20101201 |
| Novel spirotetracyclic zwitterionic dual H(1)/5-HT(2A) receptor antagonists for the treatment of sleep disorders. | Journal of medicinal chemistry 20101111 |
| The alpha2 adrenergic receptor antagonist idazoxan, but not the serotonin-2A receptor antagonist M100907, partially attenuated reward deficits associated with nicotine, but not amphetamine, withdrawal in rats. | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20101001 |
| Structural combination of established 5-HT(2A) receptor ligands: new aspects of the binding mode. | Chemical biology & drug design 20101001 |
| Differential effects of serotonin (5-HT)2 receptor-targeting ligands on locomotor responses to nicotine-repeated treatment. | Synapse (New York, N.Y.) 20100701 |
| Synergistic effect of decreased opioid activity and sleep deprivation on head-twitch response in mice. | Pharmacology, biochemistry, and behavior 20100701 |
| Increased serotonin 2A receptor availability in the orbitofrontal cortex of physically aggressive personality disordered patients. | Biological psychiatry 20100615 |
| Non-basic ligands for aminergic GPCRs: the discovery and development diaryl sulfones as selective, orally bioavailable 5-HT2A receptor antagonists for the treatment of sleep disorders. | Bioorganic & medicinal chemistry letters 20100615 |
| CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling. | Nature neuroscience 20100501 |
| 18F-labeling and evaluation of novel MDL 100907 derivatives as potential 5-HT2A antagonists for molecular imaging. | Nuclear medicine and biology 20100501 |
| Simplified quantification of 5-HT2A receptors in the human brain with [11C]MDL 100,907 PET and non-invasive kinetic analyses. | NeuroImage 20100415 |
| Antagonism at serotonin 5-HT(2A) receptors modulates functional activity of frontohippocampal circuit. | Psychopharmacology 20100301 |
| Attenuation of phencyclidine-induced object recognition deficits by the combination of atypical antipsychotic drugs and pimavanserin (ACP 103), a 5-hydroxytryptamine(2A) receptor inverse agonist. | The Journal of pharmacology and experimental therapeutics 20100201 |
| Blockade of serotonin 2A receptors prevents PCP-induced attentional performance deficit and CREB phosphorylation in the dorsal striatum of DBA/2 mice. | Psychopharmacology 20100201 |
| Enhancement of spatial reversal learning by 5-HT2C receptor antagonism is neuroanatomically specific. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100120 |
| Sertindole improves sub-chronic PCP-induced reversal learning and episodic memory deficits in rodents: involvement of 5-HT(6) and 5-HT (2A) receptor mechanisms. | Psychopharmacology 20100101 |
| 5-HT2A receptor antagonists improve motor impairments in the MPTP mouse model of Parkinson's disease. | Neuropharmacology 20100101 |
| Plaque deposition dependent decrease in 5-HT2A serotonin receptor in AbetaPPswe/PS1dE9 amyloid overexpressing mice. | Journal of Alzheimer's disease : JAD 20100101 |
| Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM), ketanserin, and (R)-(+)-{alpha}-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol (MDL100907) in rats. | The Journal of pharmacology and experimental therapeutics 20091101 |
| Combined administration of an mGlu2/3 receptor agonist and a 5-HT 2A receptor antagonist markedly attenuate the psychomotor-activating and neurochemical effects of psychostimulants. | Psychopharmacology 20091101 |
| Enhanced 5-HT(2A) receptors in brain stem and ALDH activity in brain stem and liver: 5-HT(2A) regulation on ALDH in primary hepatocytes cultures in vitro. | Neurochemical research 20090901 |
| Effect of sertindole on extracellular dopamine, acetylcholine, and glutamate in the medial prefrontal cortex of conscious rats: a comparison with risperidone and exploration of mechanisms involved. | Psychopharmacology 20090901 |
| Serotonergic hyperinnervation and effective serotonin blockade in an FGF receptor developmental model of psychosis. | Schizophrenia research 20090901 |
| Interactions of serotonin (5-HT)2 receptor-targeting ligands and nicotine: locomotor activity studies in rats. | Synapse (New York, N.Y.) 20090801 |
| Role of dopamine transporters in the behavioral effects of 3,4-methylenedioxymethamphetamine (MDMA) in nonhuman primates. | Psychopharmacology 20090801 |
| Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers. | Journal of medicinal chemistry 20090723 |
| Relevance of dorsal raphe nucleus firing in serotonin 5-HT(2C) receptor blockade-induced augmentation of SSRIs effects. | Neuropharmacology 20090701 |
| Activation of glucocorticoid receptors increases 5-HT2A receptor levels. | Experimental neurology 20090701 |
| Activation of the JAK-STAT pathway is necessary for desensitization of 5-HT2A receptor-stimulated phospholipase C signalling by olanzapine, clozapine and MDL 100907. | The international journal of neuropsychopharmacology 20090601 |
| The brain 5-HT4 receptor binding is down-regulated in the Flinders Sensitive Line depression model and in response to paroxetine administration. | Journal of neurochemistry 20090601 |
| Simultaneous telemetric monitoring of tail-skin and core body temperature in a rat model of thermoregulatory dysfunction. | Journal of neuroscience methods 20090415 |
| Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET. | Bioorganic & medicinal chemistry 20090415 |
| Genetic deletion of MAO-A promotes serotonin-dependent ventricular hypertrophy by pressure overload. | Journal of molecular and cellular cardiology 20090401 |
| Blockade of the serotonin 5-HT2A receptor suppresses cue-evoked reinstatement of cocaine-seeking behavior in a rat self-administration model. | Behavioral neuroscience 20090401 |
| Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane in rhesus monkeys: antagonism and apparent pA2 analyses. | The Journal of pharmacology and experimental therapeutics 20090301 |
| Pharmacological properties and discriminative stimulus effects of a novel and selective 5-HT2 receptor agonist AL-38022A [(S)-2-(8,9-dihydro-7H-pyrano[2,3-g]indazol-1-yl)-1-methylethylamine]. | Pharmacology, biochemistry, and behavior 20090101 |
| Endogenous serotonin and serotonin2C receptors are involved in the ability of M100907 to suppress cortical glutamate release induced by NMDA receptor blockade. | Journal of neurochemistry 20090101 |
| Fluoxetine-mediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation. | Psychopharmacology 20081201 |
| The 5-hydroxytryptamine2A receptor antagonist R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) attenuates impulsivity after both drug-induced disruption (dizocilpine) and enhancement (antidepressant drugs) of differential-reinforcement-of-low-rate 72-s behavior in the rat. | The Journal of pharmacology and experimental therapeutics 20081201 |
| Validation of a rat in vivo [(3)H]M100907 binding assay to determine a translatable measure of 5-HT(2A) receptor occupancy. | European journal of pharmacology 20080904 |
| Opposing roles for 5-HT2A and 5-HT2C receptors in the nucleus accumbens on inhibitory response control in the 5-choice serial reaction time task. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20080901 |
| The hallucinogen DOI reduces low-frequency oscillations in rat prefrontal cortex: reversal by antipsychotic drugs. | Biological psychiatry 20080901 |
| Chronic phenethylamine hallucinogen treatment alters behavioral sensitivity to a metabotropic glutamate 2/3 receptor agonist. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20080801 |
| Dissociable effects of selective 5-HT2A and 5-HT2C receptor antagonists on serial spatial reversal learning in rats. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20080701 |
| Lorcaserin, a novel selective human 5-hydroxytryptamine2C agonist: in vitro and in vivo pharmacological characterization. | The Journal of pharmacology and experimental therapeutics 20080501 |
| Evidence that genetic variation in 5-HT transporter expression is linked to changes in 5-HT2A receptor function. | Neuropharmacology 20080401 |
| 2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT2A antagonists. | Bioorganic & medicinal chemistry letters 20080315 |
| Total synthesis and evaluation of [18F]MHMZ. | Bioorganic & medicinal chemistry letters 20080215 |
| Abnormally persistent latent inhibition induced by MK801 is reversed by risperidone and by positive modulators of NMDA receptor function: differential efficacy depending on the stage of the task at which they are administered. | Psychopharmacology 20080201 |
| In vivo pharmacology of MDMA and its enantiomers in rhesus monkeys. | Experimental and clinical psychopharmacology 20080201 |
| Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents. | Pharmacology, biochemistry, and behavior 20080101 |
| The stimulus effects of 8-OH-DPAT: evidence for a 5-HT2A receptor-mediated component. | Pharmacology, biochemistry, and behavior 20080101 |
| Selective 5HT2A and 5HT6 receptor antagonists promote sleep in rats. | Sleep 20080101 |
| Effects of 5-HT drugs in prefrontal cortex during memory formation and the ketamine amnesia-model. | Hippocampus 20080101 |
| 5-HT(2A) inverse-agonists for the treatment of insomnia. | Current topics in medicinal chemistry 20080101 |
| Opposing effects of 5-HT(2A) and 5-HT(2C) receptor antagonists in the rat and mouse on premature responding in the five-choice serial reaction time test. | Psychopharmacology 20071201 |
| Behavioral response to emotional stress in rabbits: role of serotonin and serotonin2A receptors. | Behavioural pharmacology 20071101 |
| Effects of the serotonin 5-HT2A and 5-HT2C receptor ligands on the discriminative stimulus effects of nicotine in rats. | European journal of pharmacology 20071001 |
| Hippocampal Bcl-2 expression is selectively increased following chronic but not acute treatment with antidepressants, 5-HT(1A) or 5-HT(2C/2B) receptor antagonists. | European journal of pharmacology 20070813 |
| Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A-/-, 5-HT1B-/-, 5-HT2A-/-, 5-HT3A-/- and 5-HTT-/- knock-out male mice. | Pain 20070801 |
| Behavioral effects of dipropyltryptamine in rats: evidence for 5-HT1A and 5-HT2A agonist activity. | Behavioural pharmacology 20070701 |
| Blockade of 5-HT2a receptors reduces haloperidol-induced attenuation of reward. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070301 |
| 5-Hydroxytryptamine (serotonin)2A receptors in rat anterior cingulate cortex mediate the discriminative stimulus properties of d-lysergic acid diethylamide. | The Journal of pharmacology and experimental therapeutics 20070201 |
| Validation of a tracer kinetic model for the quantification of 5-HT(2A) receptors in human brain with [(11)C]MDL 100,907. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20070101 |
| Effects of d-amphetamine and DOI (2,5-dimethoxy-4-iodoamphetamine) on timing behavior: interaction between D1 and 5-HT2A receptors. | Psychopharmacology 20061201 |
| Cardiac baroreflex facilitation evoked by hypothalamus and prefrontal cortex stimulation: role of the nucleus tractus solitarius 5-HT2A receptors. | American journal of physiology. Regulatory, integrative and comparative physiology 20061001 |
| Increased 5-HT(2A) receptor binding in euthymic, medication-free patients recovered from depression: a positron emission study with [(11)C]MDL 100,907. | The American journal of psychiatry 20060901 |
| Serotonin 2A receptor antagonist treatment reduces dopamine D1 receptor-mediated rotational behavior but not L-DOPA-induced abnormal involuntary movements in the unilateral dopamine-depleted rat. | Neuropharmacology 20060501 |
| Dissociable contribution of 5-HT1A and 5-HT2A receptors in the medial prefrontal cortex to different aspects of executive control such as impulsivity and compulsive perseveration in rats. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060401 |
| Effects of 5-HT2A receptor stimulation on the discrimination of durations by rats. | Behavioural pharmacology 20060201 |
| Hallucinogen-like actions of 5-methoxy-N,N-diisopropyltryptamine in mice and rats. | Pharmacology, biochemistry, and behavior 20060101 |
| Binding characteristics of the 5-HT2A receptor antagonists altanserin and MDL 100907. | Synapse (New York, N.Y.) 20051215 |
| Use of LC/MS to assess brain tracer distribution in preclinical, in vivo receptor occupancy studies: dopamine D2, serotonin 2A and NK-1 receptors as examples. | Life sciences 20051212 |
| The selective 5-HT2A receptor antagonist M100907 enhances antidepressant-like behavioral effects of the SSRI fluoxetine. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20051201 |
| Relationship of cocaine-induced c-Fos expression to behaviors and the role of serotonin 5-HT2A receptors in cocaine-induced c-Fos expression. | Behavioral neuroscience 20051001 |
| The role of 5-HT(2A) receptor antagonism in amphetamine-induced inhibition of A10 dopamine neurons in vitro. | European journal of pharmacology 20050927 |
| Behavioral tolerance to lysergic acid diethylamide is associated with reduced serotonin-2A receptor signaling in rat cortex. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20050901 |
| Serotonin 5-HT2A but not 5-HT2C receptor antagonism reduces hyperlocomotor activity induced in dopamine-depleted rats by striatal administration of the D1 agonist SKF 82958. | Neuropharmacology 20050901 |
| Serotonergic regulation of calcium-activated potassium currents in rodent prefrontal cortex. | The European journal of neuroscience 20050901 |
| 4-Fluorosulfonylpiperidines: selective 5-HT2A ligands for the treatment of insomnia. | Bioorganic & medicinal chemistry letters 20050815 |
| The stimulus properties of LSD in C57BL/6 mice. | Pharmacology, biochemistry, and behavior 20050801 |
| Lithium differs from anticonvulsant mood stabilizers in prefrontal cortical and accumbal dopamine release: role of 5-HT(1A) receptor agonism. | Brain research 20050712 |
| Distinct temporal phases in the behavioral pharmacology of LSD: dopamine D2 receptor-mediated effects in the rat and implications for psychosis. | Psychopharmacology 20050701 |
| A role for midbrain raphe gamma aminobutyric acid neurons in 5-hydroxytryptamine feedback control. | Neuroreport 20050621 |
| Complex discriminative stimulus properties of (+)lysergic acid diethylamide (LSD) in C57Bl/6J mice. | Psychopharmacology 20050601 |
| Role of the serotonin 5-HT2A receptor in the hyperlocomotive and hyperthermic effects of (+)-3,4-methylenedioxymethamphetamine. | Psychopharmacology 20050401 |
| Serotonin 2A receptors modulate tail-skin temperature in two rodent models of estrogen deficiency-related thermoregulatory dysfunction. | Brain research 20041203 |
| 5-HT2A and 5-HT2C receptor antagonists have opposing effects on a measure of impulsivity: interactions with global 5-HT depletion. | Psychopharmacology 20041101 |
| The 5-HT receptor antagonist M100,907 prevents extracellular glutamate rising in response to NMDA receptor blockade in the mPFC. | Journal of neurochemistry 20041001 |
| Cutting edge: serotonin is a chemotactic factor for eosinophils and functions additively with eotaxin. | Journal of immunology (Baltimore, Md. : 1950) 20040915 |
| The serotonin 5-HT2A receptors antagonist M100907 prevents impairment in attentional performance by NMDA receptor blockade in the rat prefrontal cortex. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040901 |
| Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. | Naunyn-Schmiedeberg's archives of pharmacology 20040801 |
| Desensitization of 5-HT1A receptors by 5-HT2A receptors in neuroendocrine neurons in vivo. | The Journal of pharmacology and experimental therapeutics 20040701 |
| Nantenine: an antagonist of the behavioral and physiological effects of MDMA in mice. | Psychopharmacology 20040501 |
| Serotonergic facilitation of synaptic activity in the developing rat prefrontal cortex. | The Journal of physiology 20040501 |
| The selective serotonin-2A receptor antagonist M100907 reverses behavioral deficits in dopamine transporter knockout mice. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040201 |
| Discriminative stimulus properties of 1.25 and 5.0 mg/kg doses of clozapine in rats: examination of the role of dopamine, serotonin, and muscarinic receptor mechanisms. | Pharmacology, biochemistry, and behavior 20040201 |
| Fenfluramine evokes 5-HT2A receptor-mediated responses but does not displace [11C]MDL 100907: small animal PET and gene expression studies. | Synapse (New York, N.Y.) 20031201 |
| The 5-HT2A receptor antagonist M100,907 attenuates motor and 'impulsive-type' behaviours produced by NMDA receptor antagonism. | Psychopharmacology 20031101 |
| Pharmacological characterization of a serotonin receptor (5-HT7) stimulating cAMP production in human corneal epithelial cells. | Investigative ophthalmology & visual science 20031101 |
| Group II metabotropic glutamate receptor antagonists LY341495 and LY366457 increase locomotor activity in mice. | Neuropharmacology 20031001 |
| Latent inhibition in 35-day-old rats is not an 'adult' latent inhibition: implications for neurodevelopmental models of schizophrenia. | Psychopharmacology 20030901 |
| In vivo modulation of 5-hydroxytryptamine release in mouse prefrontal cortex by local 5-HT(2A) receptors: effect of antipsychotic drugs. | The European journal of neuroscience 20030901 |
| The hallucinogen 1-[2,5-dimethoxy-4-iodophenyl]-2-aminopropane (DOI) increases cortical extracellular glutamate levels in rats. | Neuroscience letters 20030807 |
| Regulation of septo-hippocampal activity by 5-hydroxytryptamine(2C) receptors. | The Journal of pharmacology and experimental therapeutics 20030801 |
| Evaluation of the ocular hypotensive response of serotonin 5-HT1A and 5-HT2 receptor ligands in conscious ocular hypertensive cynomolgus monkeys. | The Journal of pharmacology and experimental therapeutics 20030701 |
| 5-HT 2A receptor stimulation by DOI, a 5-HT 2A/2C receptor agonist, potentiates amphetamine-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens. | Brain research 20030516 |
| Intra-prefrontal 8-OH-DPAT and M100907 improve visuospatial attention and decrease impulsivity on the five-choice serial reaction time task in rats. | Psychopharmacology 20030501 |
| Generalization of clozapine as compared to other antipsychotic agents to a discriminative stimulus elicited by the serotonin (5-HT)2A antagonist, MDL100,907. | Neuropharmacology 20030401 |
| Discriminative stimulus properties of (+/-)-fenfluramine: the role of 5-HT2 receptor subtypes. | Behavioral neuroscience 20030401 |
| Pharmacological characterization of the effects of 3,4-methylenedioxymethamphetamine ('ecstasy') and its enantiomers on lethality, core temperature, and locomotor activity in singly housed and crowded mice. | Psychopharmacology 20030301 |
| Neuroendocrine evidence that (S)-2-(chloro-5-fluoro-indol- l-yl)-1-methylethylamine fumarate (Ro 60-0175) is not a selective 5-hydroxytryptamine(2C) receptor agonist. | The Journal of pharmacology and experimental therapeutics 20030301 |
| Discriminative stimulus properties of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane [(+/-)DOI] in C57BL/6J mice. | Psychopharmacology 20030201 |
| Protein kinase C is involved in clozapine's facilitation of N-methyl-D-aspartate- and electrically evoked responses in pyramidal cells of the medial prefrontal cortex. | Neuroscience 20030101 |
| Serotonin mechanisms in heart valve disease II: the 5-HT2 receptor and its signaling pathway in aortic valve interstitial cells. | The American journal of pathology 20021201 |
| Evidence that 5-HT2A receptors in the hypothalamic paraventricular nucleus mediate neuroendocrine responses to (-)DOI. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20021101 |
| Differential effects of the 5-HT(2A) receptor antagonist M100907 and the 5-HT(2C) receptor antagonist SB242084 on cocaine-induced locomotor activity, cocaine self-administration and cocaine-induced reinstatement of responding. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20021001 |
| SR46349-B, a 5-HT(2A/2C) receptor antagonist, potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20020901 |
| 5-HT(2A) receptor antagonism potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and inhibits that in the nucleus accumbens in a dose-dependent manner. | Brain research 20020830 |
| 5-HT(1A) and 5-HT(2A) receptors minimally contribute to clozapine-induced acetylcholine release in rat medial prefrontal cortex. | Brain research 20020607 |
| Synthesis, receptor potency, and selectivity of halogenated diphenylpiperidines as serotonin 5-HT2A ligands for PET or SPECT brain imaging. | Journal of medicinal chemistry 20020523 |
| The selective serotonin(2A) receptor antagonist, MDL100,907, elicits a specific interoceptive cue in rats. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20020401 |
| Attenuation of ischemic efflux of endogenous amino acids by the novel 5-HT(1A)/5-HT(2) receptor ligand adatanserin. | Neurochemistry international 20020301 |
| Comparison of the potency of MDL 100,907 and SB 242084 in blocking the serotonin (5-HT)(2) receptor agonist-induced increases in rat serum corticosterone concentrations: evidence for 5-HT(2A) receptor mediation of the HPA axis. | Neuropharmacology 20020201 |
| 4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists. | Journal of medicinal chemistry 20020117 |
| Pharmacological studies of the acute effects of (+)-3,4-methylenedioxymethamphetamine on locomotor activity: role of 5-HT(1B/1D) and 5-HT(2) receptors. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20020101 |
| Effects of phencyclidine (PCP) and MK 801 on the EEGq in the prefrontal cortex of conscious rats; antagonism by clozapine, and antagonists of AMPA-, alpha(1)- and 5-HT(2A)-receptors. | British journal of pharmacology 20020101 |
| Control of serotonergic function in medial prefrontal cortex by serotonin-2A receptors through a glutamate-dependent mechanism. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20011215 |
| Functional and pharmacological characterization of the modulatory role of serotonin on the firing activity of locus coeruleus norepinephrine neurons. | Brain research 20011213 |
| m-CPP hypolocomotion is selectively antagonized by compounds with high affinity for 5-HT(2C) receptors but not 5-HT(2A) or 5-HT(2B) receptors. | Behavioural pharmacology 20011201 |
| Effect of clozapine, haloperidol, or M100907 on phencyclidine-activated glutamate efflux in the prefrontal cortex. | Biological psychiatry 20011115 |
| Characterization of the functional heterologous desensitization of hypothalamic 5-HT(1A) receptors after 5-HT(2A) receptor activation. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20011015 |
| Multiple conformations of native and recombinant human 5-hydroxytryptamine(2a) receptors are labeled by agonists and discriminated by antagonists. | Molecular pharmacology 20011001 |
| Differential regulation of the mesoaccumbens circuit by serotonin 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20011001 |
| DOI, a 5-HT2A/2C receptor agonist, attenuates clozapine-induced cortical dopamine release. | Brain research 20010713 |
| 5-HT2A receptors stimulate ACTH, corticosterone, oxytocin, renin, and prolactin release and activate hypothalamic CRF and oxytocin-expressing cells. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20010515 |
| Acute and repeated administration of the selective 5-HT(2A) receptor antagonist M100907 significantly alters the activity of midbrain dopamine neurons: an in vivo electrophysiological study. | Synapse (New York, N.Y.) 20010501 |
| M100907, a selective 5-HT(2A) receptor antagonist, attenuates phencyclidine-induced Fos expression in discrete regions of rat brain. | European journal of pharmacology 20010413 |
| Antagonism of 5-hydroxytryptamine(2a) receptors attenuates the behavioral effects of cocaine in rats. | The Journal of pharmacology and experimental therapeutics 20010401 |
| [Synthesis and biological activities of new 5-HT2A selective ligands--N-substituted-piperidinyl-4-phenylthioether and sulfone derivatives]. | Yao xue xue bao = Acta pharmaceutica Sinica 20010401 |
| Role of 5-HT(2a) and 5-HT(2B/2C) receptors in the behavioral interactions between serotonin and catecholamine reuptake inhibitors. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010301 |
| Antagonism at 5-HT(2A) receptors potentiates the effect of haloperidol in a conditioned avoidance response task in rats. | Pharmacology, biochemistry, and behavior 20010301 |
| Current and novel approaches to the drug treatment of schizophrenia. | Journal of medicinal chemistry 20010215 |
| Mapping of 5-HT2A receptors and their mRNA in monkey brain: [3H]MDL100,907 autoradiography and in situ hybridization studies. | The Journal of comparative neurology 20010122 |
| M100,907, a selective 5-HT(2A) antagonist, attenuates dopamine release in the rat medial prefrontal cortex. | Brain research 20010105 |
| M-100907 (Aventis). | Current opinion in investigational drugs (London, England : 2000) 20010101 |
| A behavioural pattern analysis of hypoglutamatergic mice--effects of four different antipsychotic agents. | Journal of neural transmission (Vienna, Austria : 1996) 20010101 |
| Autoradiographic localization of 5-HT(2A) receptors in the human brain using [(3)H]M100907 and [(11)C]M100907. | Synapse (New York, N.Y.) 20001215 |
| 5-HT2 receptor antagonism reduces hyperactivity induced by amphetamine, cocaine, and MK-801 but not D1 agonist C-APB. | Pharmacology, biochemistry, and behavior 19990601 |
| Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist. | British journal of pharmacology 19990201 |
| Neurochemical and behavioral evidence that quipazine-ketanserin discrimination is mediated by serotonin2A receptor. | The Journal of pharmacology and experimental therapeutics 19951101 |
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