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139180-30-6 | Phenol, 4-[2-[[7-amino-2-(2-furanyl)[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]ethyl]-
CAS No: 139180-30-6 Catalog No: AG001AFV MDL No:MFCD00908394
Product Description
Catalog Number:
AG001AFV
Chemical Name:
Phenol, 4-[2-[[7-amino-2-(2-furanyl)[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]ethyl]-
CAS Number:
139180-30-6
Molecular Formula:
C16H15N7O2
Molecular Weight:
337.3360
MDL Number:
MFCD00908394
IUPAC Name:
4-[2-[[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]ethyl]phenol
InChI:
InChI=1S/C16H15N7O2/c17-14-20-15(18-8-7-10-3-5-11(24)6-4-10)21-16-19-13(22-23(14)16)12-2-1-9-25-12/h1-6,9,24H,7-8H2,(H3,17,18,19,20,21,22)
InChI Key:
PWTBZOIUWZOPFT-UHFFFAOYSA-N
SMILES:
Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1
Properties
Complexity:
435
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
337.129g/mol
Formal Charge:
0
Heavy Atom Count:
25
Hydrogen Bond Acceptor Count:
8
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
337.343g/mol
Monoisotopic Mass:
337.129g/mol
Rotatable Bond Count:
5
Topological Polar Surface Area:
127A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.2
Literature
| Title | Journal |
|---|---|
| The wakefulness promoting drug Modafinil causes adenosine receptor-mediated upregulation of receptor activator of nuclear factor κB ligand in osteoblasts: Negative impact of the drug on peak bone accrual in rats. | Toxicology and applied pharmacology 20180601 |
| Imidacloprid, a neonicotinoid insecticide, facilitates tyrosine hydroxylase transcription and phenylethanolamine N-methyltransferase mRNA expression to enhance catecholamine synthesis and its nicotine-evoked elevation in PC12D cells. | Toxicology 20180201 |
| Equilibrative nucleoside transporter ENT1 as a biomarker of Huntington disease. | Neurobiology of disease 20161201 |
| Cordycepin induces apoptosis of C6 glioma cells through the adenosine 2A receptor-p53-caspase-7-PARP pathway. | Chemico-biological interactions 20140605 |
| Adenosine A2A receptor as a drug discovery target. | Journal of medicinal chemistry 20140508 |
| Resveratrol mediates anti-atherogenic effects on cholesterol flux in human macrophages and endothelium via PPARγ and adenosine. | European journal of pharmacology 20130105 |
| Adenosine A2A receptor modulates vascular response in soluble epoxide hydrolase-null mice through CYP-epoxygenases and PPARγ. | American journal of physiology. Regulatory, integrative and comparative physiology 20130101 |
| A novel dihydro-pyrazolo(3,4d)(1,2,4)triazolo(1,5a)pyrimidin-4-one (AJ23) is an antagonist at adenosine A(1) receptors and enhances consolidation of step-down avoidance. | Behavioural brain research 20121001 |
| Pharmacological blockade of adenosine A2A receptors diminishes scarring. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20121001 |
| The mechanism of beta-adrenergic preconditioning: roles for adenosine and ROS during triggering and mediation. | Basic research in cardiology 20120901 |
| mGlu5 and adenosine A2A receptor interactions regulate the conditioned effects of cocaine. | The international journal of neuropsychopharmacology 20120801 |
| The effect of adenosine A(2A) receptor antagonists on hydroxyl radical, dopamine, and glutamate in the striatum of rats with altered function of VMAT2. | Neurotoxicity research 20120801 |
| Structural basis for allosteric regulation of GPCRs by sodium ions. | Science (New York, N.Y.) 20120713 |
| Suppression of bladder overactivity by adenosine A2A receptor antagonist in a rat model of Parkinson disease. | The Journal of urology 20120501 |
| The effect of A(2A) adenosine receptor activation on C-C chemokine receptor 7 expression in human THP1 macrophages during inflammation. | Inflammation 20120401 |
| Effect of adenosine A2A receptor antagonist ZM241385 on amygdala-kindled seizures and progression of amygdala kindling. | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20120401 |
| Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: role for the adenosine A(2A) receptor. | European journal of pharmacology 20120305 |
| Effect of adenosine A(2A) receptor antagonists and L-DOPA on hydroxyl radical, glutamate and dopamine in the striatum of 6-OHDA-treated rats. | Neurotoxicity research 20120201 |
| Functional interaction between purinergic receptors: effect of ligands for A2A and P2Y12 receptors on P2Y1 receptor function. | FEBS letters 20111215 |
| Adenosine reduces cell surface expression of toll-like receptor 4 and inflammation in response to lipopolysaccharide and matrix products. | Journal of cardiovascular translational research 20111201 |
| Computational study of the binding modes of caffeine to the adenosine A2A receptor. | The journal of physical chemistry. B 20111201 |
| Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine. | Structure (London, England : 1993) 20110907 |
| Adenosine A(2A) receptor activation prevents progressive kidney fibrosis in a model of immune-associated chronic inflammation. | Kidney international 20110801 |
| New 2-heterocyclyl-imidazo[2,1-i]purin-5-one derivatives as potent and selective human A3 adenosine receptor antagonists. | Journal of medicinal chemistry 20110728 |
| Biophysical mapping of the adenosine A2A receptor. | Journal of medicinal chemistry 20110714 |
| Adenosine A2(A) receptor modulates the oxidative stress response of primed polymorphonuclear leukocytes after parabolic flight. | Human immunology 20110701 |
| Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation. | Nature 20110518 |
| Structural features of adenosine receptors: from crystal to function. | Biochimica et biophysica acta 20110501 |
| Structure of an agonist-bound human A2A adenosine receptor. | Science (New York, N.Y.) 20110415 |
| Abnormal calcium handling in atrial fibrillation is linked to up-regulation of adenosine A2A receptors. | European heart journal 20110301 |
| Discovery of phosphoric acid mono-{2-[(E/Z)-4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} ester (Lu AA47070): a phosphonooxymethylene prodrug of a potent and selective hA(2A) receptor antagonist. | Journal of medicinal chemistry 20110210 |
| Synthesis and biological evaluation of a new series of 1,2,4-triazolo[1,5-a]-1,3,5-triazines as human A(2A) adenosine receptor antagonists with improved water solubility. | Journal of medicinal chemistry 20110210 |
| GPCR structure and activation: an essential role for the first extracellular loop in activating the adenosine A2B receptor. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110201 |
| Pyrimidine derivatives as potent and selective A3 adenosine receptor antagonists. | Journal of medicinal chemistry 20110127 |
| Differential recruitment of high affinity A1 and A2A adenosine receptors in the control of colonic neuromuscular function in experimental colitis. | European journal of pharmacology 20110115 |
| Involvement of adenosine signaling in controlling the release of ghrelin from the mouse stomach. | The Journal of pharmacology and experimental therapeutics 20110101 |
| A(2A) adenosine receptor binding parameters in platelets from patients affected by pathological gambling. | Neuropsychobiology 20110101 |
| Adenosine receptor regulation of coronary blood flow in Ossabaw miniature swine. | The Journal of pharmacology and experimental therapeutics 20101201 |
| Peripheral adenosine A2A receptors are involved in carrageenan-induced mechanical hyperalgesia in mice. | Neuroscience 20101027 |
| Cooperative cardioprotection through adenosine A1 and A2A receptor agonism in ischemia-reperfused isolated mouse heart. | Journal of cardiovascular pharmacology 20101001 |
| Inosine reduces pain-related behavior in mice: involvement of adenosine A1 and A2A receptor subtypes and protein kinase C pathways. | The Journal of pharmacology and experimental therapeutics 20100801 |
| Adenosine A(2) receptors modulate tubuloglomerular feedback. | American journal of physiology. Renal physiology 20100801 |
| Adenosine A(2)A receptor but not HIF-1 mediates Tyrosine hydroxylase induction in hypoxic PC12 cells. | Journal of neuroscience research 20100701 |
| Lipopolysaccharide and TNF-alpha modify adenosine A(2A) receptor expression and function in equine monocytes. | Veterinary immunology and immunopathology 20100615 |
| Priming of signal transducer and activator of transcription proteins for cytokine-triggered polyubiquitylation and degradation by the A 2A adenosine receptor. | Molecular pharmacology 20100601 |
| Activation of adenosine A2A receptor attenuates inflammatory response in a rat model of small-for-size liver transplantation. | Transplantation proceedings 20100601 |
| Acadesine inhibits tissue factor induction and thrombus formation by activating the phosphoinositide 3-kinase/Akt signaling pathway. | Arteriosclerosis, thrombosis, and vascular biology 20100501 |
| Adenosine activates a2b receptors and enhances chloride secretion in kidney inner medullary collecting duct cells. | Hypertension (Dallas, Tex. : 1979) 20100501 |
| Ligand binding and subtype selectivity of the human A(2A) adenosine receptor: identification and characterization of essential amino acid residues. | The Journal of biological chemistry 20100423 |
| Role of adenosine A2 receptors in regulation of cerebral blood flow during induced hypotension. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20100401 |
| Predicted 3D structures for adenosine receptors bound to ligands: comparison to the crystal structure. | Journal of structural biology 20100401 |
| Adenosine inhibits paraventricular pre-sympathetic neurons through ATP-dependent potassium channels. | Journal of neurochemistry 20100401 |
| Synthesis of theophylline derivatives and study of their activity as antagonists at adenosine receptors. | Bioorganic & medicinal chemistry 20100315 |
| DNA methylation regulates adenosine A(2A) receptor cell surface expression levels. | Journal of neurochemistry 20100301 |
| The role of adenosine receptors in regulating production of tumour necrosis factor-alpha and chemokines by human lung macrophages. | British journal of pharmacology 20100301 |
| Blockade of adenosine A2A receptor counteracts neuropeptide-S-induced hyperlocomotion in mice. | Naunyn-Schmiedeberg's archives of pharmacology 20100201 |
| Static magnetic field exposure reproduces cellular effects of the Parkinson's disease drug candidate ZM241385. | PloS one 20100101 |
| 2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a new scaffold to obtain potent and selective human A3 adenosine receptor antagonists: new insights into the receptor-antagonist recognition. | Journal of medicinal chemistry 20091210 |
| Inhibition of the adenosine2A receptor-epoxyeicosatrienoic acid pathway renders Dahl salt-resistant rats hypertensive. | Hypertension (Dallas, Tex. : 1979) 20091201 |
| Human follicular lymphoma CD39+-infiltrating T cells contribute to adenosine-mediated T cell hyporesponsiveness. | Journal of immunology (Baltimore, Md. : 1950) 20091115 |
| Homology modelling of the human adenosine A2B receptor based on X-ray structures of bovine rhodopsin, the beta2-adrenergic receptor and the human adenosine A2A receptor. | Journal of computer-aided molecular design 20091101 |
| Differential regulation of HIF-1alpha isoforms in murine macrophages by TLR4 and adenosine A(2A) receptor agonists. | Journal of leukocyte biology 20090901 |
| Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation. | Journal of hepatology 20090901 |
| Region-specific neuroprotective effect of ZM 241385 towards glutamate uptake inhibition in cultured neurons. | European journal of pharmacology 20090901 |
| Adenosine A2A receptors enable the synaptic effects of cannabinoid CB1 receptors in the rodent striatum. | Journal of neurochemistry 20090901 |
| Angiotensin II enhances the afferent arteriolar response to adenosine through increases in cytosolic calcium. | Acta physiologica (Oxford, England) 20090801 |
| Role of ATP and related purines in inhibitory neurotransmission to the pig urinary bladder neck. | British journal of pharmacology 20090801 |
| Adenosine A1 receptors presynaptically modulate excitatory synaptic input onto subiculum neurons. | Brain research 20090714 |
| The adenosine A2A receptor antagonist ZM241385 enhances neuronal survival after oxygen-glucose deprivation in rat CA1 hippocampal slices. | British journal of pharmacology 20090701 |
| Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008. | Nature reviews. Drug discovery 20090601 |
| Synthesis of a series of 8-(substituted-phenyl)xanthines and a study on the effects of substitution pattern of phenyl substituents on affinity for adenosine A(1) and A(2A) receptors. | European journal of medicinal chemistry 20090501 |
| Regulation of somatostatin release by adenosine in the mouse stomach. | The Journal of pharmacology and experimental therapeutics 20090501 |
| Multiple receptor subtypes and multiple mechanisms of dilation are involved in vascular network dilation caused by adenosine. | Microvascular research 20090501 |
| Cardioprotection induced by adenosine A1 receptor agonists in a cardiac cell ischemia model involves cooperative activation of adenosine A2A and A2B receptors by endogenous adenosine. | Journal of cardiovascular pharmacology 20090501 |
| A2A adenosine receptor antagonists protect the striatum against rotenone-induced neurotoxicity. | Experimental neurology 20090501 |
| Activation of NTS A2a adenosine receptors differentially resets baroreflex control of renal vs. adrenal sympathetic nerve activity. | American journal of physiology. Heart and circulatory physiology 20090401 |
| Nitric oxide (NO) does not contribute to the generation or action of adenosine during exercise hyperaemia in rat hindlimb. | The Journal of physiology 20090401 |
| Elucidation in the rat of the role of adenosine and A2A-receptors in the hyperaemia of twitch and tetanic contractions. | The Journal of physiology 20090401 |
| Adenosine A1 and A2a receptors modulate insulinemia, glycemia, and lactatemia in fetal sheep. | American journal of physiology. Regulatory, integrative and comparative physiology 20090301 |
| Adenosine receptor antagonists improve short-term object-recognition ability of spontaneously hypertensive rats: a rodent model of attention-deficit hyperactivity disorder. | Behavioural pharmacology 20090301 |
| The role of adenosine A(1) receptors in mediating the inhibitory effects of low frequency stimulation of perforant path on kindling acquisition in rats. | Neuroscience 20090218 |
| Modulation of gamma oscillations by endogenous adenosine through A1 and A2A receptors in the mouse hippocampus. | Neuropharmacology 20090201 |
| Caffeine modulates TNF-alpha production by cord blood monocytes: the role of adenosine receptors. | Pediatric research 20090201 |
| Effect of adenosine A(2A) receptor antagonists on L-DOPA-induced hydroxyl radical formation in rat striatum. | Neurotoxicity research 20090201 |
| Adenosine A(1) and A(2A) receptors in mouse prefrontal cortex modulate acetylcholine release and behavioral arousal. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20090121 |
| Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A2A adenosine receptor in rats. | Journal of gastroenterology 20090101 |
| Alcohol-induced retrograde memory impairment in rats: prevention by caffeine. | Psychopharmacology 20081201 |
| FGF acts as a co-transmitter through adenosine A(2A) receptor to regulate synaptic plasticity. | Nature neuroscience 20081201 |
| Atheroprotective effects of methotrexate on reverse cholesterol transport proteins and foam cell transformation in human THP-1 monocyte/macrophages. | Arthritis and rheumatism 20081201 |
| The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. | Science (New York, N.Y.) 20081121 |
| Cerebral blood flow response in adenosine 2a receptor knockout mice during transient hypoxic hypoxia. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20081001 |
| Neonatal caffeine induces sex-specific developmental plasticity of the hypoxic respiratory chemoreflex in adult rats. | American journal of physiology. Regulatory, integrative and comparative physiology 20080901 |
| Adenosine receptor subtypes in the airways responses to 5'-adenosine monophosphate inhalation of sensitized guinea-pigs. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20080901 |
| Human equilibrative nucleoside transporters 1 and 2 may be differentially modulated by A2B adenosine receptors in placenta microvascular endothelial cells from pre-eclampsia. | Placenta 20080901 |
| 2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists. | Journal of medicinal chemistry 20080814 |
| Pharmacological blockade of A2A receptors prevents dermal fibrosis in a model of elevated tissue adenosine. | The American journal of pathology 20080601 |
| Involvement of the adenosine A1 and A2A receptors in the antidepressant-like effect of zinc in the forced swimming test. | Progress in neuro-psychopharmacology & biological psychiatry 20080515 |
| Hypotensive effects of intravenously administered uridine and cytidine in conscious rats: involvement of adenosine receptors. | European journal of pharmacology 20080414 |
| Up-regulation of adenosine receptors in the frontal cortex in Alzheimer's disease. | Brain pathology (Zurich, Switzerland) 20080401 |
| Stimulation of adenosine A2A receptor inhibits LPS-induced expression of intercellular adhesion molecule 1 and production of TNF-alpha in human peripheral blood mononuclear cells. | Shock (Augusta, Ga.) 20080201 |
| Adenosine A2A receptor agonists inhibit lipopolysaccharide-induced production of tumor necrosis factor-alpha by equine monocytes. | Veterinary immunology and immunopathology 20080115 |
| Adenosine A(2A) receptors are required for normal BDNF levels and BDNF-induced potentiation of synaptic transmission in the mouse hippocampus. | Journal of neurochemistry 20080101 |
| Activation of adenosine 2A receptors preserves structure and function of podocytes. | Journal of the American Society of Nephrology : JASN 20080101 |
| Critical role of hypoxia and A2A adenosine receptors in liver tissue-protecting physiological anti-inflammatory pathway. | Molecular medicine (Cambridge, Mass.) 20080101 |
| Interaction of A2A adenosine and D2 dopamine receptors modulates corticostriatal glutamatergic transmission. | Neuropharmacology 20071101 |
| Purinergic modulation of glutamate release under ischemic-like conditions in the hippocampus. | Neuroscience 20071012 |
| Targeted deletion of A2A adenosine receptors attenuates the protective effects of myocardial postconditioning. | American journal of physiology. Heart and circulatory physiology 20071001 |
| The role of adenosine A1 and A2A receptors of entorhinal cortex on piriform cortex kindled seizures in rats. | Pharmacological research 20070801 |
| Blockade of adenosine A(2A) receptors prevents staurosporine-induced apoptosis of rat hippocampal neurons. | Neurobiology of disease 20070801 |
| Endogenous expression of adenosine A1, A2 and A3 receptors in rat C6 glioma cells. | Neurochemical research 20070601 |
| Adenosine closes the K+ channel KCa3.1 in human lung mast cells and inhibits their migration via the adenosine A2A receptor. | European journal of immunology 20070601 |
| Effects of stimulation of adenosine A2A receptors on lipopolysaccharide-induced production of reactive oxygen species by equine neutrophils. | American journal of veterinary research 20070601 |
| Anticonvulsant effect of A1 but not A2A adenosine receptors of piriform cortex in amygdala-kindled rats. | Canadian journal of physiology and pharmacology 20070601 |
| Increase in A2A receptors in the nucleus accumbens after extended cocaine self-administration and its disappearance after cocaine withdrawal. | Brain research 20070427 |
| Disruption of adenosinergic modulation of ventilation at rest and during hypercapnia by neonatal caffeine in young rats: role of adenosine A(1) and A(2A) receptors. | American journal of physiology. Regulatory, integrative and comparative physiology 20070401 |
| Interleukin-1beta but not tumor necrosis factor-alpha potentiates neuronal damage by quinolinic acid: protection by an adenosine A2A receptor antagonist. | Journal of neuroscience research 20070401 |
| Activation of adenosine 2A receptors attenuates allograft rejection and alloantigen recognition. | Journal of immunology (Baltimore, Md. : 1950) 20070401 |
| Attenuation of reperfusion lung injury and apoptosis by A2A adenosine receptor activation is associated with modulation of Bcl-2 and Bax expression and activation of extracellular signal-regulated kinases. | Shock (Augusta, Ga.) 20070301 |
| Cell death in rat cerebellar granule neurons induced by hydrogen peroxide in vitro: mechanisms and protection by adenosine receptor ligands. | Brain research 20070209 |
| Stimulation of adenosine A1 and A2A receptors by AMP in the submucosal plexus of guinea pig small intestine. | American journal of physiology. Gastrointestinal and liver physiology 20070201 |
| Tonic adenosine A1 and A2A receptor activation is required for the excitatory action of VIP on synaptic transmission in the CA1 area of the hippocampus. | Neuropharmacology 20070201 |
| ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor. | The Journal of pharmacology and experimental therapeutics 20070201 |
| A novel mechanism of vasoregulation: ADP-induced relaxation of the porcine isolated coronary artery is mediated via adenosine release. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070201 |
| The A2a/A2b receptor antagonist ZM-241385 blocks the cardioprotective effect of adenosine agonist pretreatment in in vivo rat myocardium. | American journal of physiology. Heart and circulatory physiology 20070101 |
| Adenosine A2A receptor modulation of juvenile female rat skeletal muscle microvessel permeability. | American journal of physiology. Heart and circulatory physiology 20061201 |
| Cl-IB-MECA [2-chloro-N6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide] reduces ischemia/reperfusion injury in mice by activating the A3 adenosine receptor. | The Journal of pharmacology and experimental therapeutics 20061201 |
| Deficits of glutamate transmission in the striatum of experimental hemiballism. | Neuroscience 20061117 |
| Adenosine receptors located in the NTS contribute to renal sympathoinhibition during hypotensive phase of severe hemorrhage in anesthetized rats. | American journal of physiology. Heart and circulatory physiology 20061101 |
| Expression of adenosine receptors in cardiac fibroblasts as a function of insulin and glucose level. | Archives of biochemistry and biophysics 20061101 |
| Corpus cavernosum from men with vasculogenic impotence is partially resistant to adenosine relaxation due to endothelial A(2B) receptor dysfunction. | The Journal of pharmacology and experimental therapeutics 20061001 |
| Mouse spinal cord compression injury is reduced by either activation of the adenosine A2A receptor on bone marrow-derived cells or deletion of the A2A receptor on non-bone marrow-derived cells. | Neuroscience 20060915 |
| Contribution of adenosine A2A and A2B receptors and heme oxygenase to AMPA-induced dilation of pial arterioles in rats. | American journal of physiology. Regulatory, integrative and comparative physiology 20060901 |
| Role of adenosine A1 receptors in the modulation of dopamine D1 and adenosine A2A receptor signaling in the neostriatum. | Neuroscience 20060811 |
| Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis. | British journal of pharmacology 20060801 |
| Contribution of adenosine receptors in the control of arteriolar tone and adenosine-angiotensin II interaction. | Kidney international 20060801 |
| Adenosine A2A receptors in diffuse dermal fibrosis: pathogenic role in human dermal fibroblasts and in a murine model of scleroderma. | Arthritis and rheumatism 20060801 |
| Functional and cytoarchitectural spinal cord protection by ATL-146e after ischemia/reperfusion is mediated by adenosine receptor agonism. | Journal of vascular surgery 20060801 |
| Both endothelium and afferent nerve endings play a role in acetylcholine-induced renal vasodilation. | Life sciences 20060724 |
| Early and transient alteration of adenosine A2A receptor signaling in a mouse model of Huntington disease. | Neurobiology of disease 20060701 |
| Adenosine A2A receptor stimulation decreases GAT-1-mediated GABA uptake in the globus pallidus of the rat. | Neuropharmacology 20060701 |
| Caffeine inhibition of rat carotid body chemoreceptors is mediated by A2A and A2B adenosine receptors. | Journal of neurochemistry 20060701 |
| Characterization of [125I]ZM 241385 binding to adenosine A2A receptors in the pineal of sheep brain. | Brain research 20060622 |
| Adenosine as an active component of Antrodia cinnamomea that prevents rat PC12 cells from serum deprivation-induced apoptosis through the activation of adenosine A(2A) receptors. | Life sciences 20060613 |
| Adenosine A2A receptors promote adenosine-stimulated wound healing in bronchial epithelial cells. | American journal of physiology. Lung cellular and molecular physiology 20060501 |
| Adenosine A2A receptor inactivation increases survival in polymicrobial sepsis. | Journal of immunology (Baltimore, Md. : 1950) 20060501 |
| Neurogenic secretion mediated by the purinergic P2Y1 receptor in guinea-pig small intestine. | European journal of pharmacology 20060424 |
| Complement activation-related cardiac anaphylaxis in pigs: role of C5a anaphylatoxin and adenosine in liposome-induced abnormalities in ECG and heart function. | American journal of physiology. Heart and circulatory physiology 20060301 |
| Adenosine receptors as therapeutic targets. | Nature reviews. Drug discovery 20060301 |
| Dialysis delivery of an adenosine A2A agonist into the pontine reticular formation of C57BL/6J mouse increases pontine acetylcholine release and sleep. | Journal of neurochemistry 20060301 |
| Tachycardia caused by A2A adenosine receptor agonists is mediated by direct sympathoexcitation in awake rats. | The Journal of pharmacology and experimental therapeutics 20060201 |
| A2a receptors mediate inhibitory effects of adenosine on colonic motility in the presence of experimental colitis. | Inflammatory bowel diseases 20060201 |
| Adenosine concentration in the porcine coronary artery wall and A2A receptor involvement in hypoxia-induced vasodilatation. | The Journal of physiology 20060115 |
| Contractile effects of adenosine A1 and A2A receptors in isolated murine hearts. | American journal of physiology. Heart and circulatory physiology 20060101 |
| The cellular mechanisms by which adenosine evokes release of nitric oxide from rat aortic endothelium. | The Journal of physiology 20060101 |
| Adenosine A1 and A2A receptors of hippocampal CA1 region have opposite effects on piriform cortex kindled seizures in rats. | Seizure 20060101 |
| Effects of the A 2A adenosine receptor antagonist KW6002 in the nucleus accumbens in vitro and in vivo. | Pharmacology, biochemistry, and behavior 20060101 |
| The role of adenosine A2a receptors in experimental acute pancreatitis. | Advances in medical sciences 20060101 |
| 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization. | Journal of medicinal chemistry 20051103 |
| Lipopolysaccharide rapidly modifies adenosine receptor transcripts in murine and human macrophages: role of NF-kappaB in A(2A) adenosine receptor induction. | The Biochemical journal 20051101 |
| Adenosine A2A receptor stimulation potentiates nitric oxide release by activated microglia. | Journal of neurochemistry 20051101 |
| Synthesis of [1,2,4]triazolo[1,5-a]pyrazines as adenosine A2A receptor antagonists. | Bioorganic & medicinal chemistry letters 20051101 |
| Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050706 |
| Postconditioning reduces infarct size via adenosine receptor activation by endogenous adenosine. | Cardiovascular research 20050701 |
| Adenosine receptors co-operate with NMDA preconditioning to protect cerebellar granule cells against glutamate neurotoxicity. | Neuropharmacology 20050701 |
| Requisite roles of A2A receptors, nitric oxide, and KATP channels in retinal arteriolar dilation in response to adenosine. | Investigative ophthalmology & visual science 20050601 |
| Effect of sleep deprivation on righting reflex in the rat is partially reversed by administration of adenosine A1 and A2 receptor antagonists. | Anesthesiology 20050601 |
| Adenosine A2A-receptor blockade abolishes the roll-off respiratory response to hypoxia in awake lambs. | American journal of physiology. Regulatory, integrative and comparative physiology 20050501 |
| A2B adenosine receptor mediates human chorionic vasoconstriction and signals through arachidonic acid cascade. | American journal of physiology. Heart and circulatory physiology 20050501 |
| In vivo adenosine receptor preconditioning reduces myocardial infarct size via subcellular ERK signaling. | American journal of physiology. Heart and circulatory physiology 20050501 |
| Adenosine A2A receptor stimulation increases angiogenesis by down-regulating production of the antiangiogenic matrix protein thrombospondin 1. | Molecular pharmacology 20050501 |
| Activation of adenosine receptors in the posterior cingulate cortex impairs memory retrieval in the rat. | Neurobiology of learning and memory 20050501 |
| Blockade of adenosine A2A receptors reverses short-term social memory impairments in spontaneously hypertensive rats. | Behavioural brain research 20050430 |
| Pharmacological characterisation of the adenosine receptor mediating increased ion transport in the mouse isolated trachea and the effect of allergen challenge. | British journal of pharmacology 20050401 |
| Adenosine agonist regulation of outward active transport of fluorescein across retinal pigment epithelium in rabbits. | Experimental eye research 20050401 |
| Novel diamino derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists. | Journal of medicinal chemistry 20050324 |
| Modulation of short-term social memory in rats by adenosine A1 and A(2A) receptors. | Neuroscience letters 20050316 |
| Adenosine contributes to mu-opioid synaptic inhibition in rat substantia gelatinosa in vitro. | Neuroscience letters 20050311 |
| Kinetic and functional properties of [3H]ZM241385, a high affinity antagonist for adenosine A2A receptors. | Life sciences 20050211 |
| Upregulation of A2A adenosine receptor expression by TNF-alpha in PBMC of patients with CHF: a regulatory mechanism of inflammation. | Journal of cardiac failure 20050201 |
| A2A adenosine receptor induction inhibits IFN-gamma production in murine CD4+ T cells. | Journal of immunology (Baltimore, Md. : 1950) 20050115 |
| Effects of adenosine and adenosine A2A receptor agonist on motor nerve conduction velocity and nerve blood flow in experimental diabetic neuropathy. | Neurological research 20050101 |
| Characterization of [3H]ZM 241385 binding in wild-type and adenosine A2A receptor knockout mice. | European journal of pharmacology 20041103 |
| Adenosine A1 receptors modulate the anxiolytic-like effect of ethanol in the elevated plus-maze in mice. | European journal of pharmacology 20040919 |
| Adenosine A2A receptor occupancy stimulates expression of proteins involved in reverse cholesterol transport and inhibits foam cell formation in macrophages. | Journal of leukocyte biology 20040901 |
| Striatal adenosine A(2A) receptor blockade increases extracellular dopamine release following l-DOPA administration in intact and dopamine-denervated rats. | Neuropharmacology 20040901 |
| Permissive role of adenosine A2A receptors on metabotropic glutamate receptor 5 (mGluR5)-mediated effects in the striatum. | Journal of neurochemistry 20040901 |
| Piperazine derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists. | Journal of medicinal chemistry 20040812 |
| [3H]OSIP339391, a selective, novel, and high affinity antagonist radioligand for adenosine A2B receptors. | Biochemical pharmacology 20040715 |
| Adenosine's role in hypercapnia-evoked cerebral vasodilation in the rat. | Neuroscience letters 20040715 |
| Adenosine A2A receptor blockade differentially influences excitotoxic mechanisms at pre- and postsynaptic sites in the rat striatum. | Journal of neuroscience research 20040701 |
| Comparison of inhibitory activity of isomeric triazolopyridine derivatives towards adenosine receptor subtypes or do similar structures reveal similar bioactivities? | Bioorganic & medicinal chemistry letters 20040621 |
| A2A adenosine receptor activation improves survival in mouse models of endotoxemia and sepsis. | The Journal of infectious diseases 20040515 |
| The role of intraspinal adenosine A1 receptors in sympathetic regulation. | European journal of pharmacology 20040510 |
| Role of adenosine A2A receptor in the regulation of gastric somatostatin release. | The Journal of pharmacology and experimental therapeutics 20040501 |
| AMPA receptor-mediated presynaptic inhibition at cerebellar GABAergic synapses: a characterization of molecular mechanisms. | The European journal of neuroscience 20040501 |
| Endogenous adenosine modulates epileptiform activity in rat hippocampus in a receptor subtype-dependent manner. | The European journal of neuroscience 20040501 |
| Adenosine A 2A receptor antagonists prevent the increase in striatal glutamate levels induced by glutamate uptake inhibitors. | Journal of neurochemistry 20040401 |
| Activation of adenosine A2A receptor facilitates brain-derived neurotrophic factor modulation of synaptic transmission in hippocampal slices. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20040324 |
| Neutrophils both reduce and increase permeability in a cell culture model of the blood-brain barrier. | Brain research 20040220 |
| Protection from ischemic liver injury by activation of A2A adenosine receptors during reperfusion: inhibition of chemokine induction. | American journal of physiology. Gastrointestinal and liver physiology 20040201 |
| Binding of tritiated and radioiodinated ZM241,385 to brain A2A adenosine receptors. | Nuclear medicine and biology 20040201 |
| Adenosine administration produces an antidepressant-like effect in mice: evidence for the involvement of A1 and A2A receptors. | Neuroscience letters 20040123 |
| Input-specific modulation of neurotransmitter release in the lateral horn of the spinal cord via adenosine receptors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20040107 |
| Adenosine A2A receptors and depression. | Neurology 20031209 |
| Modulation of A2A adenosine receptors and associated Galphas proteins by ZM 241385 treatment of porcine coronary artery. | Journal of cardiovascular pharmacology 20031201 |
| Involvement of adenosine A1 receptors in forced walking stress-induced analgesia in mice. | Methods and findings in experimental and clinical pharmacology 20031201 |
| Effect of taurine deficiency on adenosine receptor-mediated relaxation of the rat aorta. | Vascular pharmacology 20031101 |
| LTP-induced depression of response to hypoxia in hippocampus: effects of adenosine receptor activation. | Neuroreport 20031006 |
| The effect of caffeine on peripheral vascular resistance in isolated perfused guinea pig hind limbs. | Journal of cardiovascular pharmacology 20031001 |
| Adenosine-A2a receptor down-regulates cerebral smooth muscle L-type Ca2+ channel activity via protein tyrosine phosphatase, not cAMP-dependent protein kinase. | Molecular pharmacology 20030901 |
| Brief, repeated, oxygen-glucose deprivation episodes protect neurotransmission from a longer ischemic episode in the in vitro hippocampus: role of adenosine receptors. | British journal of pharmacology 20030901 |
| Effects of adenosine receptor antagonists on pial arteriolar dilation during carbon dioxide inhalation. | European journal of pharmacology 20030829 |
| Enhanced adenosine A2A receptor facilitation of synaptic transmission in the hippocampus of aged rats. | Journal of neurophysiology 20030801 |
| Functional expression of adenosine A2A and A3 receptors in the mouse dendritic cell line XS-106. | European journal of pharmacology 20030801 |
| Selective A2A, but not A1 adenosine antagonists enhance the anticataleptic action of trihexyphenidyl in rats. | Neuroscience letters 20030731 |
| Adenosine A 2B receptors modulate cAMP levels and induce CREB but not ERK1/2 and p38 phosphorylation in rat skeletal muscle cells. | Biochemical and biophysical research communications 20030718 |
| Involvement of adenosine A1 and A2A receptors in the motor effects of caffeine after its acute and chronic administration. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030701 |
| The human D2 dopamine receptor synergizes with the A2A adenosine receptor to stimulate adenylyl cyclase in PC12 cells. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030701 |
| Rapid modification of the glycocalyx caused by ischemia-reperfusion is inhibited by adenosine A2A receptor activation. | American journal of physiology. Heart and circulatory physiology 20030601 |
| Induction of neurite outgrowth in PC12 cells by the bacterial nucleoside N6-methyldeoxyadenosine is mediated through adenosine A2a receptors and via cAMP and MAPK signaling pathways. | Biochemical and biophysical research communications 20030516 |
| Adenosine receptors mediate glutamate-evoked arteriolar dilation in the rat cerebral cortex. | American journal of physiology. Heart and circulatory physiology 20030501 |
| Neuroprotection by caffeine and adenosine A2A receptor blockade of beta-amyloid neurotoxicity. | British journal of pharmacology 20030401 |
| Changes of peripheral A2A adenosine receptors in chronic heart failure and cardiac transplantation. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030201 |
| Regional differences in the adenosine A(2) receptor-mediated modulation of contractions in rat vas deferens. | European journal of pharmacology 20030124 |
| Low ethanol sensitivity and increased ethanol consumption in mice lacking adenosine A2A receptors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20021201 |
| Effects of doxazosin and propranolol on A2A adenosine receptors in essential hypertension. | Hypertension (Dallas, Tex. : 1979) 20021201 |
| Localization of adenosine A2A-receptors in rat brain with [3H]ZM-241385. | Naunyn-Schmiedeberg's archives of pharmacology 20021101 |
| Transducing system operated by adenosine A(2A) receptors to facilitate acetylcholine release in the rat hippocampus. | European journal of pharmacology 20021101 |
| KF24345, an adenosine uptake inhibitor, ameliorates the severity and mortality of lethal acute pancreatitis via endogenous adenosine in mice. | European journal of pharmacology 20021101 |
| Characterization of adenosine receptors mediating the vasodilator effects of adenosine receptor agonists in the microvasculature of the hamster cheek pouch in vivo. | Autonomic & autacoid pharmacology 20020801 |
| Facilitation of noradrenaline release by adenosine A(2A) receptors in the epididymal portion and adenosine A(2B) receptors in the prostatic portion of the rat vas deferens. | European journal of pharmacology 20020712 |
| Selective allosteric enhancement of agonist binding and function at human A3 adenosine receptors by a series of imidazoquinoline derivatives. | Molecular pharmacology 20020701 |
| Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxin. | The American journal of pathology 20020601 |
| Effects of adenosine receptor agonists on guinea-pig isolated working hearts and the role of endothelium and NO. | The Journal of pharmacy and pharmacology 20020601 |
| Adenosine A(2A) receptors mediate hypoxic inhibition of fetal breathing in sheep. | American journal of obstetrics and gynecology 20020401 |
| Effects of CGS 21680, a selective adenosine A2A receptor agonist, on allergic airways inflammation in the rat. | European journal of pharmacology 20020308 |
| Functional characterization of adenosine receptors and coupling to ATP-sensitive K+ channels in Guinea pig urinary bladder smooth muscle. | The Journal of pharmacology and experimental therapeutics 20020301 |
| Adenosine A(2A) receptors in portal hypertension: their role in the abnormal response to adenosine of the cranial mesenteric artery in rabbits. | British journal of pharmacology 20020301 |
| KF24345, an adenosine uptake inhibitor, suppresses lipopolysaccharide-induced tumor necrosis factor-alpha production and leukopenia via endogenous adenosine in mice. | The Journal of pharmacology and experimental therapeutics 20020101 |
| Purification and characterization of the human adenosine A(2a) receptor functionally expressed in Escherichia coli. | European journal of biochemistry 20020101 |
| Hippocampal injury and neurobehavioral deficits following hyperglycemic cerebral ischemia: effect of theophylline and ZM 241385. | Journal of neurosurgery 20020101 |
| Adenosine A(2A) receptor facilitation of hippocampal synaptic transmission is dependent on tonic A(1) receptor inhibition. | Neuroscience 20020101 |
| Purines and neuroprotection. | Advances in experimental medicine and biology 20020101 |
| Adenosine inhibits excitatory transmission to substantia gelatinosa neurons of the adult rat spinal cord through the activation of presynaptic A(1) adenosine receptor. | Pain 20011201 |
| Solubilisation and immunoprecipitation of rat striatal adenosine A(2A) receptors. | European journal of pharmacology 20011116 |
| Effect of adenosine receptor blockade on pial arteriolar dilation during sciatic nerve stimulation. | American journal of physiology. Heart and circulatory physiology 20011101 |
| Oxygen delivery and oxygen consumption in rat hindlimb during systemic hypoxia: role of adenosine. | The Journal of physiology 20011101 |
| Adenosine-mediated hypotension in in vivo guinea-pig: receptors involved and role of NO. | British journal of pharmacology 20011001 |
| Suppression of presynaptic responses to adenosine by activation of NMDA receptors. | European journal of pharmacology 20010907 |
| Adenosine-mediated inhibition of striatal GABAergic synaptic transmission during in vitro ischaemia. | Brain : a journal of neurology 20010901 |
| Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia. | British journal of pharmacology 20010901 |
| Role of adenosine and P2 receptors in the penile tumescence in anesthetized dogs. | European journal of pharmacology 20010803 |
| AMP-activated protein kinase is highly expressed in neurons in the developing rat brain and promotes neuronal survival following glucose deprivation. | Journal of molecular neuroscience : MN 20010801 |
| Selective A(2A) adenosine receptor activation reduces skin pressure ulcer formation and inflammation. | American journal of physiology. Heart and circulatory physiology 20010701 |
| Adenosine A(1) and A(2A) receptors modulate sleep state and breathing in fetal sheep. | Journal of applied physiology (Bethesda, Md. : 1985) 20010701 |
| Novel short-acting A2A adenosine receptor agonists for coronary vasodilation: inverse relationship between affinity and duration of action of A2A agonists. | The Journal of pharmacology and experimental therapeutics 20010701 |
| Receptor subtypes mediating adenosine-induced dilation of cerebral arterioles. | American journal of physiology. Heart and circulatory physiology 20010501 |
| Adenosine A(2A) receptor stimulation reduces inflammation and neointimal growth in a murine carotid ligation model. | Arteriosclerosis, thrombosis, and vascular biology 20010501 |
| Adenosine A(2A) receptor enhances GABA(A)-mediated IPSCs in the rat globus pallidus. | The Journal of physiology 20010415 |
| [3H]MRS 1754, a selective antagonist radioligand for A(2B) adenosine receptors. | Biochemical pharmacology 20010315 |
| Absence of the adenosine A(2A) receptor or its chronic blockade decrease ethanol withdrawal-induced seizures in mice. | Neuropharmacology 20010301 |
| Cyclic AMP-dependent inhibition of human neutrophil oxidative activity by substituted 2-propynylcyclohexyl adenosine A(2A) receptor agonists. | British journal of pharmacology 20010301 |
| Functional and molecular characterization of receptor subtypes mediating coronary microvascular dilation to adenosine. | Journal of molecular and cellular cardiology 20010201 |
| [(3)H]ZM241385--an antagonist radioligand for adenosine A(2A) receptors in rat brain. | European journal of pharmacology 20010112 |
| Adenosine A(2A) receptors mediate cardiovascular responses to hypoxia in fetal sheep. | American journal of physiology. Heart and circulatory physiology 20010101 |
| Potentiation of cytokine induction of group IIA phospholipase A(2) in rat mesangial cells by ATP and adenosine via the A2A adenosine receptor. | British journal of pharmacology 20010101 |
| Inactivation of adenosine A2A receptor impairs long term potentiation in the accumbens nucleus without altering basal synaptic transmission. | Neuroscience 20010101 |
| Role of endothelium in ischaemia-induced myocardial dysfunction of isolated working hearts: cardioprotection by activation of adenosine A(2A) receptors. | Journal of autonomic pharmacology 20010101 |
| Why are A(2B) receptors low-affinity adenosine receptors? Mutation of Asn273 to Tyr increases affinity of human A(2B) receptor for 2-(1-Hexynyl)adenosine. | Molecular pharmacology 20001201 |
| Site-directed mutagenesis studies of human A(2A) adenosine receptors: involvement of glu(13) and his(278) in ligand binding and sodium modulation. | Biochemical pharmacology 20000901 |
| Use of the triazolotriazine [3H]ZM 241385 as a radioligand at recombinant human A2B adenosine receptors. | Drug design and discovery 19991101 |
| Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells. | Molecular pharmacology 19991001 |
| Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors. | Naunyn-Schmiedeberg's archives of pharmacology 19990101 |
| 125I-4-(2-[7-amino-2-[2-furyl][1,2,4]triazolo[2,3-a][1,3,5] triazin-5-yl-amino]ethyl)phenol, a high affinity antagonist radioligand selective for the A2a adenosine receptor. | Molecular pharmacology 19951201 |
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