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13870-90-1

13870-90-1 | Cobinamide, Co-(5'-deoxyadenosin-5'-yl)-, f-(dihydrogen phosphate),inner salt, 3'-ester with(5,6-dimethyl-1-a-D-ribofuranosyl-1H-benzimidazole-kN3)

CAS No: 13870-90-1 Catalog No: AG01CB8H MDL No:MFCD00135609

Product Description

Catalog Number:
AG01CB8H
Chemical Name:
Cobinamide, Co-(5'-deoxyadenosin-5'-yl)-, f-(dihydrogen phosphate),inner salt, 3'-ester with(5,6-dimethyl-1-a-D-ribofuranosyl-1H-benzimidazole-kN3)
CAS Number:
13870-90-1
Molecular Formula:
C72H107CoN18O17P
Molecular Weight:
1586.6373
MDL Number:
MFCD00135609
IUPAC Name:
(2S,3S,4R,5R)-2-(6-aminopurin-9-yl)-5-methanidyloxolane-3,4-diol;cobalt(3+);[(2R,3S,4R,5S)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2R)-1-[3-[(1R,2R,3R,4Z,7S,9Z,12S,13S,14Z,17S,18S,19R)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-21-id-3-yl]propanoylamino]propan-2-yl] phosphate
InChI:
InChI=1S/C62H90N13O14P.C10H12N5O3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);2-4,6-7,10,16-17H,1H2,(H2,11,12,13);/q;-1;+3/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57+,59-,60+,61+,62+;4-,6+,7+,10+;/m11./s1
InChI Key:
OAJLVMGLJZXSGX-SLAFOUTOSA-L
SMILES:
OC[C@H]1O[C@H]2[C@@H]([C@@H]1OP(=O)([O-])O[C@H](C)CNC(=O)CC[C@]1(C3=C(C4=[N]5[Co+3]67(n8cn2c2cc(C)c(cc82)C)([CH2-][C@H]2O[C@H]([C@@H]([C@@H]2O)O)n2cnc8c2ncnc8N)[N]2=C(C=C5C([C@@H]4CCC(=O)N)(C)C)[C@H]([C@](C2=C(C2=[N]7[C@]([C@H]([N-]36)[C@@H]1CC(=O)N)(C)[C@@]([C@@H]2CCC(=O)N)(C)CC(=O)N)C)(C)CC(=O)N)CCC(=O)N)C)C)O
EC Number:
237-627-6

Properties

Complexity:
3730  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
18  
Defined Bond Stereocenter Count:
3  
Exact Mass:
1578.658g/mol
Formal Charge:
0
Heavy Atom Count:
109  
Hydrogen Bond Acceptor Count:
27  
Hydrogen Bond Donor Count:
12  
Isotope Atom Count:
0
Molecular Weight:
1579.608g/mol
Monoisotopic Mass:
1578.658g/mol
Rotatable Bond Count:
27  
Topological Polar Surface Area:
571A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0

Literature

Title Journal
Ultrafast infrared spectral fingerprints of vitamin B12 and related cobalamins. The journal of physical chemistry. A 20120614
Corrin ring-induced redox tuning. Chemical communications (Cambridge, England) 20120511
Improvement of adenosylcobalamin production by metabolic control strategy in Propionibacterium freudenreichii. Applied biochemistry and biotechnology 20120501
Redesign of coenzyme B(12) dependent diol dehydratase to be resistant to the mechanism-based inactivation by glycerol and act on longer chain 1,2-diols. The FEBS journal 20120301
Role of histidine 225 in adenosylcobalamin-dependent ornithine 4,5-aminomutase. Bioorganic chemistry 20120201
Initial step of B12-dependent enzymatic catalysis: energetic implications regarding involvement of the one-electron-reduced form of adenosylcobalamin cofactor. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20120201
Large-scale domain conformational change is coupled to the activation of the Co-C bond in the B12-dependent enzyme ornithine 4,5-aminomutase: a computational study. Journal of the American Chemical Society 20120201
Leukoencephalopathies associated with disorders of cobalamin and folate metabolism. Seminars in neurology 20120201
The elusive 5'-deoxyadenosyl radical in coenzyme-B12-mediated reactions. Journal of the American Chemical Society 20120125
Biochemistry of B12-cofactors in human metabolism. Sub-cellular biochemistry 20120101
Engineered protein nano-compartments for targeted enzyme localization. PloS one 20120101
Glutamate racemization and catabolism in Fusobacterium varium. The FEBS journal 20110701
Characterization of protein contributions to cobalt-carbon bond cleavage catalysis in adenosylcobalamin-dependent ethanolamine ammonia-lyase by using photolysis in the ternary complex. Journal of the American Chemical Society 20110511
Inborn errors of cobalamin absorption and metabolism. American journal of medical genetics. Part C, Seminars in medical genetics 20110215
How coenzyme B12-dependent ethanolamine ammonia-lyase deals with both enantiomers of 2-amino-1-propanol as substrates: structure-based rationalization. Biochemistry 20110201
Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation. The Journal of biological chemistry 20101203
Diol dehydratase-reactivating factor is a reactivase--evidence for multiple turnovers and subunit swapping with diol dehydratase. The FEBS journal 20101201
Structural basis for adenosylcobalamin activation in AdoCbl-dependent ribonucleotide reductases. ACS chemical biology 20101015
Multiple roles of ATP:cob(I)alamin adenosyltransferases in the conversion of B12 to coenzyme B12. Applied microbiology and biotechnology 20100901
Crystal structures of ethanolamine ammonia-lyase complexed with coenzyme B12 analogs and substrates. The Journal of biological chemistry 20100820
Kinetic isolation and characterization of the radical rearrangement step in coenzyme B12-dependent ethanolamine ammonia-lyase. Journal of the American Chemical Society 20100721
Theoretical analysis of the diradical nature of adenosylcobalamin cofactor-tyrosine complex in B12-dependent mutases: inspiring PCET-driven enzymatic catalysis. The journal of physical chemistry. B 20100506
Thermolability of mutant MMACHC protein in the vitamin B12-responsive cblC disorder. Molecular genetics and metabolism 20100501
Large-scale domain dynamics and adenosylcobalamin reorientation orchestrate radical catalysis in ornithine 4,5-aminomutase. The Journal of biological chemistry 20100430
Hydrogen tunneling in adenosylcobalamin-dependent glutamate mutase: evidence from intrinsic kinetic isotope effects measured by intramolecular competition. Biochemistry 20100413
Adenosyl radical: reagent and catalyst in enzyme reactions. Chembiochem : a European journal of chemical biology 20100322
Inactivation of Lactobacillus leichmannii ribonucleotide reductase by 2',2'-difluoro-2'-deoxycytidine 5'-triphosphate: adenosylcobalamin destruction and formation of a nucleotide-based radical. Biochemistry 20100223
Inactivation of Lactobacillus leichmannii ribonucleotide reductase by 2',2'-difluoro-2'-deoxycytidine 5'-triphosphate: covalent modification. Biochemistry 20100223
A human vitamin B12 trafficking protein uses glutathione transferase activity for processing alkylcobalamins. The Journal of biological chemistry 20091127
Radical triplets and suicide inhibition in reactions of 4-thia-D- and 4-thia-L-lysine with lysine 5,6-aminomutase. Biochemistry 20090901
On the importance of ribose orientation in the substrate activation of the coenzyme B12-dependent mutases. Chemistry (Weinheim an der Bergstrasse, Germany) 20090824
A rotary mechanism for coenzyme B(12) synthesis by adenosyltransferase. Biochemistry 20090616
Stabilization of the base-off forms of vitamin B(12) and coenzyme B(12) by encapsulation of the alpha-axial 5,6-dimethylbenzimidazole ligand with cucurbit[7]uril. Dalton transactions (Cambridge, England : 2003) 20090514
Residue Phe112 of the human-type corrinoid adenosyltransferase (PduO) enzyme of Lactobacillus reuteri is critical to the formation of the four-coordinate Co(II) corrinoid substrate and to the activity of the enzyme. Biochemistry 20090414
Low-solubility glycerol dehydratase, a chimeric enzyme of coenzyme B12 -dependent glycerol and diol dehydratases. Archives of microbiology 20090301
Photolysis of adenosylcobalamin and radical pair recombination in ethanolamine ammonia-lyase probed on the micro- to millisecond time scale by using time-resolved optical absorption spectroscopy. Biochemistry 20090113
Metabolite profiling uncovers plasmid-induced cobalt limitation under methylotrophic growth conditions. PloS one 20090101
Roles of adenine anchoring and ion pairing at the coenzyme B12-binding site in diol dehydratase catalysis. The FEBS journal 20081201
Interactions between coenzyme B12 analogs and adenosylcobalamin-dependent glutamate mutase from Clostridium tetanomorphum. The FEBS journal 20081201
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases. The Journal of biological chemistry 20081121
Identification of the substrate radical intermediate derived from ethanolamine during catalysis by ethanolamine ammonia-lyase. Biochemistry 20081028
Mechanism-based inactivation of coenzyme B12-dependent diol dehydratase by 3-unsaturated 1,2-diols and thioglycerol. Journal of biochemistry 20081001
But-3-ene-1,2-diol: a mechanism-based active site inhibitor for coenzyme B12-dependent glycerol dehydratase. Chembiochem : a European journal of chemical biology 20080922
Kinetic and spectroscopic studies of the ATP:corrinoid adenosyltransferase PduO from Lactobacillus reuteri: substrate specificity and insights into the mechanism of Co(II)corrinoid reduction. Biochemistry 20080826
Riboswitch effectors as protein enzyme cofactors. RNA (New York, N.Y.) 20080601
Causes of and diagnostic approach to methylmalonic acidurias. Journal of inherited metabolic disease 20080601
Structural characterization of a human-type corrinoid adenosyltransferase confirms that coenzyme B12 is synthesized through a four-coordinate intermediate. Biochemistry 20080527
Critical role of arginine 160 of the EutB protein subunit for active site structure and radical catalysis in coenzyme B12-dependent ethanolamine ammonia-lyase. Biochemistry 20080520
Pseudomonas aeruginosa, under DNA replication inhibition, tends to form biofilms via Arr. Research in microbiology 20080501
The PduX enzyme of Salmonella enterica is an L-threonine kinase used for coenzyme B12 synthesis. The Journal of biological chemistry 20080425
Identification, characterization, and structure/function analysis of a corrin reductase involved in adenosylcobalamin biosynthesis. The Journal of biological chemistry 20080418
Kinetic and thermodynamic characterization of Co(II)-substrate radical pair formation in coenzyme B12-dependent ethanolamine ammonia-lyase in a cryosolvent system by using time-resolved, full-spectrum continuous-wave electron paramagnetic resonance spectroscopy. Journal of the American Chemical Society 20080409
Histidine-alpha143 assists 1,2-hydroxyl group migration and protects radical intermediates in coenzyme B12-dependent diol dehydratase. Biochemistry 20080311
The complete coenzyme B12 biosynthesis gene cluster of Lactobacillus reuteri CRL1098. Microbiology (Reading, England) 20080101
B12-retro-riboswitches: guanosyl-induced constitutional switching of B12 coenzymes. Chemistry (Weinheim an der Bergstrasse, Germany) 20080101
Magnetic field effect studies indicate reduced geminate recombination of the radical pair in substrate-bound adenosylcobalamin-dependent ethanolamine ammonia lyase. Journal of the American Chemical Society 20071219
Molecular basis for specificities of reactivating factors for adenosylcobalamin-dependent diol and glycerol dehydratases. The FEBS journal 20071101
Long-term outcome in methylmalonic acidurias is influenced by the underlying defect (mut0, mut-, cblA, cblB). Pediatric research 20070801
5'-Peroxyadenosine and 5'-peroxyadenosylcobalamin as intermediates in the aerobic photolysis of adenosylcobalamin. Biochemistry 20070619
Dioldehydrase: an essential role for potassium ion in the homolytic cleavage of the cobalt-carbon bond in adenosylcobalamin. Biochemistry 20070619
Probing interactions from solvent-exchangeable protons and monovalent cations with the 1,2-propanediol-1-yl radical intermediate in the reaction of dioldehydrase. Protein science : a publication of the Protein Society 20070601
Regulation by SREBP-2 defines a potential link between isoprenoid and adenosylcobalamin metabolism. Biochemical and biophysical research communications 20070406
Construction and characterization of hybrid dehydratases between adenosylcobalamin-dependent diol and glycerol dehydratases. Journal of nutritional science and vitaminology 20070401
First principles study of coenzyme B12. Crystal packing forces effect on axial bond lengths. The journal of physical chemistry. B 20070329
S-adenosylmethionine as an oxidant: the radical SAM superfamily. Trends in biochemical sciences 20070301
Computational mutation analysis of hydrogen abstraction and radical rearrangement steps in the catalysis of coenzyme B12-dependent diol dehydratase. Chemistry (Weinheim an der Bergstrasse, Germany) 20070101
Tandem riboswitch architectures exhibit complex gene control functions. Science (New York, N.Y.) 20061013
Reaction of adenosylcobalamin-dependent glutamate mutase with 2-thiolglutarate. Biochemistry 20060926
Assembly and protection of the radical enzyme, methylmalonyl-CoA mutase, by its chaperone. Biochemistry 20060801
DFT analysis of co-alkyl and co-adenosyl vibrational modes in B12-cofactors. Inorganic chemistry 20060710
Survey of catalytic residues and essential roles of glutamate-alpha170 and aspartate-alpha335 in coenzyme B12-dependent diol dehydratase. The Journal of biological chemistry 20060707
The enzymatic activation of coenzyme B12. Dalton transactions (Cambridge, England : 2003) 20060307
Renal transplantation in a 14-year-old girl with vitamin B12-responsive cblA-type methylmalonic acidaemia. Pediatric nephrology (Berlin, Germany) 20060201
Computational insights into the mechanism of radical generation in B12-dependent methylmalonyl-CoA mutase. Journal of the American Chemical Society 20060201
Radical enzymes in anaerobes. Annual review of microbiology 20060101
Propionyl-CoA and adenosylcobalamin metabolism in Caenorhabditis elegans: evidence for a role of methylmalonyl-CoA epimerase in intermediary metabolism. Molecular genetics and metabolism 20060101
Stabilisation of methylene radicals by cob(II)alamin in coenzyme B12 dependent mutases. Chemistry (Weinheim an der Bergstrasse, Germany) 20051223
Release of a damaged cofactor from a coenzyme B12-dependent enzyme: X-ray structures of diol dehydratase-reactivating factor. Structure (London, England : 1993) 20051201
Electronic structure studies of the adenosylcobalamin cofactor in glutamate mutase. Biochemistry 20051122
Acid-, base-, and lewis-acid-catalyzed heterolysis of methoxide from an alpha-hydroxy-beta-methoxy radical: models for reactions catalyzed by coenzyme B12-dependent diol dehydratase. The Journal of organic chemistry 20051111
Time-resolved measurements of the photolysis and recombination of adenosylcobalamin bound to glutamate mutase. The journal of physical chemistry. B 20050929
Searching for intermediates in the carbon skeleton rearrangement of 2-methyleneglutarate to (R)-3-methylitaconate catalyzed by coenzyme B12-dependent 2-methyleneglutarate mutase from Eubacterium barkeri. Biochemistry 20050809
How the Co-C bond is cleaved in coenzyme B12 enzymes: a theoretical study. Journal of the American Chemical Society 20050629
Spectroscopic and computational studies of the ATP:corrinoid adenosyltransferase (CobA) from Salmonella enterica: insights into the mechanism of adenosylcobalamin biosynthesis. Journal of the American Chemical Society 20050622
Crystallization and preliminary X-ray analysis of molecular chaperone-like diol dehydratase-reactivating factor in ADP-bound and nucleotide-free forms. Acta crystallographica. Section F, Structural biology and crystallization communications 20050601
Development of a method for the separation of corrinoids in ovine tissues by HPLC. Biomedical chromatography : BMC 20050501
Two proteins mediate class II ribonucleotide reductase activity in Pseudomonas aeruginosa: expression and transcriptional analysis of the aerobic enzymes. The Journal of biological chemistry 20050429
Characterization of the product radical structure in the Co(II)-product radical pair state of coenzyme B12-dependent ethanolamine deaminase by using three-pulse 2H ESEEM spectroscopy. Biochemistry 20050308
Active site reactant center geometry in the Co(II)-product radical pair state of coenzyme B12-dependent ethanolamine deaminase determined by using orientation-selection electron spin-echo envelope modulation spectroscopy. The journal of physical chemistry. B 20050224
Isotope effects for deuterium transfer between substrate and coenzyme in adenosylcobalamin-dependent glutamate mutase. Biochemistry 20050222
Identification of the 1,2-propanediol-1-yl radical as an intermediate in adenosylcobalamin-dependent diol dehydratase reaction. Biochemistry 20050215
Homocoenzyme B12 and bishomocoenzyme B12: covalent structural mimics for homolyzed, enzyme-bound coenzyme B12. Chemistry (Weinheim an der Bergstrasse, Germany) 20041217
Catalytic roles of active-site amino acid residues of coenzyme B12-dependent diol dehydratase: protonation state of histidine and pull effect of glutamate. Journal of the American Chemical Society 20041215
Solution structure and thermolysis of Cobeta-5'-deoxyadenosylimidazolylcobamide, a coenzyme B12 analogue with an imidazole axial nucleoside. Inorganic chemistry 20041213
Mutations in the MMAA gene in patients with the cblA disorder of vitamin B12 metabolism. Human mutation 20041201
Human ATP:Cob(I)alamin adenosyltransferase and its interaction with methionine synthase reductase. The Journal of biological chemistry 20041112
Coexpression, purification and characterization of the E and S subunits of coenzyme B(12) and B(6) dependent Clostridium sticklandii D-ornithine aminomutase in Escherichia coli. European journal of biochemistry 20041101
The cblD defect causes either isolated or combined deficiency of methylcobalamin and adenosylcobalamin synthesis. The Journal of biological chemistry 20041008
Radical mechanisms in adenosylcobalamin-dependent enzymes. Current opinion in chemical biology 20041001
The putative elaiophylin biosynthetic gene cluster in Streptomyces sp. DSM4137 is adjacent to genes encoding adenosylcobalamin-dependent methylmalonyl CoA mutase and to genes for synthesis of cobalamin. Journal of biotechnology 20040930
Enzymes: by chance, or by design? Nature 20040923
Spectroscopic and computational studies on the adenosylcobalamin-dependent methylmalonyl-CoA mutase: evaluation of enzymatic contributions to Co-C bond activation in the Co3+ ground state. Journal of the American Chemical Society 20040707
When a spectator turns killer: suicidal electron transfer from cobalamin in methylmalonyl-CoA mutase. Biochemistry 20040706
Direct determination of product radical structure reveals the radical rearrangement pathway in a coenzyme B12-dependent enzyme. Journal of the American Chemical Society 20040519
Role of Arg100 in the active site of adenosylcobalamin-dependent glutamate mutase. Biochemistry 20040323
Pre-steady-state measurement of intrinsic secondary tritium isotope effects associated with the homolysis of adenosylcobalamin and the formation of 5'-deoxyadensosine in glutamate mutase. Biochemistry 20040302
Accurate redetermination of the X-ray structure and electronic bonding in adenosylcobalamin. Inorganic chemistry 20040223
Photolysis and recombination of adenosylcobalamin bound to glutamate mutase. Journal of the American Chemical Society 20040218
Solution structure, enzymatic, and non-enzymatic reactivity of 3-isoadenosylcobalamin, a structural isomer of coenzyme B12 with surprising coenzymic activity. Journal of inorganic biochemistry 20040201
[The aeration-dependent effect of vitamin B12 on DNA biosynthesis in Methylobacterium dichloromethanicum]. Mikrobiologiia 20040101
Determination of vitamin B12 using the enzyme glycerol dehydrase. Scandinavian journal of clinical and laboratory investigation 20040101
[Study of the effect of Stressen on homocysteine blood levels in patients affected by vascular disease]. La Clinica terapeutica 20040101
[Effect of Stressen on homocysteine blood levels in patients with cardiovascular disease or at risk by familial anamnesis]. La Clinica terapeutica 20040101
[Controlled study of the effect of Stressen on homocysteine blood levels in patients with vascular disease]. La Clinica terapeutica 20040101
Comparative genomics of the vitamin B12 metabolism and regulation in prokaryotes. The Journal of biological chemistry 20031017
Neuropsychiatric disturbances in presumed late-onset cobalamin C disease. Archives of neurology 20031001
Metabolic engineering for the microbial production of 1,3-propanediol. Current opinion in biotechnology 20031001
The Co(I) induced methylmalonyl-succinyl rearrangement in a model for the coenzyme B12 dependent methylmalonyl-CoA mutase. Organic & biomolecular chemistry 20030921
The first experimental test of the hypothesis that enzymes have evolved to enhance hydrogen tunneling. Journal of the American Chemical Society 20030910
A compelling experimental test of the hypothesis that enzymes have evolved to enhance quantum mechanical tunneling in hydrogen transfer reactions: the beta-neopentylcobalamin system combined with prior adocobalamin data. Inorganic chemistry 20030811
Radical carbon skeleton rearrangements: catalysis by coenzyme B12-dependent mutases. Chemical reviews 20030601
Spectroscopic and computational studies of Co3+-corrinoids: spectral and electronic properties of the B12 cofactors and biologically relevant precursors. Journal of the American Chemical Society 20030514
Carboxylate-substituted radicals from phenylselenide derivatives. Designs on models for coenzyme B12-dependent enzyme-catalyzed rearrangements. Journal of the American Chemical Society 20030507
Alpha-5,6-dimethylbenzimidazole adenine dinucleotide (alpha-DAD), a putative new intermediate of coenzyme B12 biosynthesis in Salmonella typhimurium. Microbiology (Reading, England) 20030401
Synthesis of enantiomerically-pure [13C]aristeromycylcobalamin and its reactivity in dioldehydratase, glyceroldehydratase, ethanolamine ammonia-lyase and methylmalonyl-CoA mutase reactions. Chemistry (Weinheim an der Bergstrasse, Germany) 20030203
Internal degrees of freedom, structural motifs, and conformational energetics of the 5'-deoxyadenosyl radical: implications for function in adenosylcobalamin-dependent enzymes. A computational study. Journal of the American Chemical Society 20030115
Pre-steady-state kinetic studies on the Glu171Gln active site mutant of adenosylcobalamin-dependent glutamate mutase. Biochemistry 20021231
A (ribo) switch in the paradigms of genetic regulation. Nature structural biology 20021201
Functions of the D-ribosyl moiety and the lower axial ligand of the nucleotide loop of coenzyme B(12) in diol dehydratase and ethanolamine ammonia-lyase reactions. Journal of biochemistry 20021201
Rotation of the exo-methylene group of (R)-3-methylitaconate catalyzed by coenzyme B(12)-dependent 2-methyleneglutarate mutase from Eubacterium barkeri. Journal of the American Chemical Society 20021127
Understanding the mechanism of action of B12-dependent ethanolamine ammonia-lyase: synergistic interactions at play. Journal of the American Chemical Society 20021127
Substrate-induced conformational change of a coenzyme B12-dependent enzyme: crystal structure of the substrate-free form of diol dehydratase. Biochemistry 20021022
Biosynthetic studies on the tropane alkaloid hyoscyamine in Datura stramonium; hyoscyamine is stable to in vivo oxidation and is not derived from littorine via a vicinal interchange process. Phytochemistry 20021001
Steric control of organic transformation by a dendrimer cage: organocobalt dendrimer porphyrins as novel coenzyme B(12) mimics. Journal of the American Chemical Society 20020925
The crystal structure of coenzyme B12-dependent glycerol dehydratase in complex with cobalamin and propane-1,2-diol. European journal of biochemistry 20020901
Synthesis of adenosylcobinamide 2-chlorophenyl phosphate, a zwitterionic cobinamide phosphate analog of adenosylcobalamin en route to crystallizable cobinamides. Journal of inorganic biochemistry 20020815
Biosynthesis of cobalamin (vitamin B(12)). Biochemical Society transactions 20020801
Identification of a novel pyridoxal 5'-phosphate binding site in adenosylcobalamin-dependent lysine 5,6-aminomutase from Porphyromonas gingivalis. Biochemistry 20020709
Metabolic treatment of pregnancy and postdelivery period in a patient with cobalamin A disease. American journal of obstetrics and gynecology 20020701
Importance of the histidine ligand to coenzyme B12 in the reaction catalyzed by methylmalonyl-CoA mutase. The Journal of biological chemistry 20020524
A novel reaction between adenosylcobalamin and 2-methyleneglutarate catalyzed by glutamate mutase. Biochemistry 20020305
Interactions of diol dehydrase and 3',4'-anhydroadenosylcobalamin: suicide inactivation by electron transfer. Biochemistry 20020205
[Radical-catalyzed enzymatic reactions: structure and mechanism of B12 enzymes]. Seikagaku. The Journal of Japanese Biochemical Society 20020201
Time-resolved spectroscopic studies of B(12) coenzymes: a comparison of the primary photolysis mechanism in methyl-, ethyl-, n-propyl-, and 5'-deoxyadenosylcobalamin. Journal of the American Chemical Society 20020123
Enzymatic radical catalysis: coenzyme B12-dependent diol dehydratase. Chemical record (New York, N.Y.) 20020101
Adenosylcobalamin-dependent glutamate mutase: pre-steady-state kinetic methods for investigating reaction mechanism. Methods in enzymology 20020101
Prevention of homocysteine thiolactone induced atherogenesis in rats. Research communications in molecular pathology and pharmacology 20020101
Energetic feasibility of hydrogen abstraction and recombination in coenzyme B(12)-dependent diol dehydratase reaction. Journal of biochemistry 20011201
The role of the active site glutamate in the rearrangement of glutamate to 3-methylaspartate catalyzed by adenosylcobalamin-dependent glutamate mutase. Chemistry & biology 20011201
Enzymatic activity of coenzyme B(12) derivatives with altered axial nucleotides: probing the mechanochemical triggering hypothesis in ribonucleotide reductase. Inorganic chemistry 20011105
Tritium partitioning and isotope effects in adenosylcobalamin-dependent glutamate mutase. Biochemistry 20011030
Simultaneous measurement of intra- and intermolecular NOEs in differentially labeled protein-ligand complexes. Journal of biomolecular NMR 20011001
Characterization and mechanism of action of a reactivating factor for adenosylcobalamin-dependent glycerol dehydratase. The Journal of biological chemistry 20010928
Enzyme catalysis of 1,2-amino shifts: the cooperative action of B6, B12, and aminomutases. Journal of the American Chemical Society 20010912
Interaction of the substrate radical and the 5'-deoxyadenosine-5'-methyl group in vitamin B(12) coenzyme-dependent ethanolamine deaminase. Journal of the American Chemical Society 20010905
The B(12)-binding subunit of glutamate mutase from Clostridium tetanomorphum traps the nucleotide moiety of coenzyme B(12). Journal of molecular biology 20010608
Electron transfer in the substrate-dependent suicide inactivation of lysine 5,6-aminomutase. Biochemistry 20010501
Protein-coenzyme interactions in adenosylcobalamin-dependent glutamate mutase. The Biochemical journal 20010401
Identification and expression of the genes and purification and characterization of the gene products involved in reactivation of coenzyme B12-dependent glycerol dehydratase of Citrobacter freundii. European journal of biochemistry 20010401
Cobalamin (Cbl) C/D deficiency: clinical, neurophysiological and neuroradiologic findings in 14 cases. Neuropediatrics 20010201
Molecular modeling of the mechanochemical triggering mechanism for catalysis of carbon-cobalt bond homolysis in coenzyme B12. Journal of inorganic biochemistry 20010115
The coenzyme b12 analog 5'-deoxyadenosylcobinamide-gdp supports catalysis by methylmalonyl-coa mutase in the absence of trans-ligand coordination. The Journal of biological chemistry 20010112
5'-Deoxyadenosine contacts the substrate radical intermediate in the active site of ethanolamine ammonia-lyase: 2H and 13C electron nuclear double resonance studies. Biochemistry 20010109
Radical mechanisms of enzymatic catalysis. Annual review of biochemistry 20010101
The role of radicals in enzymatic processes. Chemical record (New York, N.Y.) 20010101
Cobalamin inhibition of HIV-1 integrase and integration of HIV-1 DNA into cellular DNA. Biochemical and biophysical research communications 19980519
Inhibition of productive human immunodeficiency virus-1 infection by cobalamins. Blood 19950815
Depressive effects of mu and delta opioid receptor agonists on activities of dorsal horn neurones are enhanced by dibencozide. The Journal of pharmacology and experimental therapeutics 19910601

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