200,000+ products from a single source!
sales@angenechem.com
138298-79-0 | 8-Azaspiro[4.5]decane-7,9-dione, 8-[4-[[(3S)-3,4-dihydro-5-methoxy-2H-1-benzopyran-3-yl]propylamino]butyl]-
CAS No: 138298-79-0 Catalog No: AG0018H0 MDL No:
Product Description
Catalog Number:
AG0018H0
Chemical Name:
8-Azaspiro[4.5]decane-7,9-dione, 8-[4-[[(3S)-3,4-dihydro-5-methoxy-2H-1-benzopyran-3-yl]propylamino]butyl]-
CAS Number:
138298-79-0
Molecular Formula:
C26H38N2O4
Molecular Weight:
442.5909
IUPAC Name:
8-[4-[[(3S)-5-methoxy-3,4-dihydro-2H-chromen-3-yl]-propylamino]butyl]-8-azaspiro[4.5]decane-7,9-dione
InChI:
InChI=1S/C26H38N2O4/c1-3-13-27(20-16-21-22(31-2)9-8-10-23(21)32-19-20)14-6-7-15-28-24(29)17-26(18-25(28)30)11-4-5-12-26/h8-10,20H,3-7,11-19H2,1-2H3/t20-/m0/s1
InChI Key:
DLLULNTXJPATBC-FQEVSTJZSA-N
SMILES:
COc1cccc2c1C[C@H](CCCNCCCCN1C(=O)CC3(CC1=O)CCCC3)CO2
UNII:
34E28BM822
Properties
Complexity:
628
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
1
Defined Bond Stereocenter Count:
0
Exact Mass:
442.283g/mol
Formal Charge:
0
Heavy Atom Count:
32
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
442.6g/mol
Monoisotopic Mass:
442.283g/mol
Rotatable Bond Count:
9
Topological Polar Surface Area:
59.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.6
Literature
| Title | Journal |
|---|---|
| Imbalanced Dopaminergic Transmission Mediated by Serotonergic Neurons in L-DOPA-Induced Dyskinesia. | Parkinson's disease 20120101 |
| Effects of acute tryptophan depletion on brain serotonin function and concentrations of dopamine and norepinephrine in C57BL/6J and BALB/cJ mice. | PloS one 20120101 |
| Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness. | Molecular brain 20110101 |
| Antidepressant potential of nitrogen-containing heterocyclic moieties: An updated review. | Journal of pharmacy & bioallied sciences 20110101 |
| An fMRI study on the role of serotonin in reactive aggression. | PloS one 20110101 |
| Serotonin synthesis, release and reuptake in terminals: a mathematical model. | Theoretical biology & medical modelling 20100101 |
| 5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis. | European journal of pharmacology 20051205 |
| Efficient single nucleotide polymorphism discovery in laboratory rat strains using wild rat-derived SNP candidates. | BMC genomics 20050101 |
| Activation of serotonergic neurotransmission during the performance of aggressive behavior in rats. | Behavioral neuroscience 20030801 |
| 5-HT1A agonists: alcohol drinking in rats and squirrel monkeys. | Psychopharmacology 20030501 |
| In vivo comparison of two 5-HT1A receptors agonists alnespirone (S-20499) and buspirone on locus coeruleus neuronal activity. | European journal of pharmacology 20030110 |
| Enhanced sensitivity of postsynaptic serotonin-1A receptors in rats and mice with high trait aggression. | Physiology & behavior 20010901 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.