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137624-14-7

137624-14-7 | 3H-Oxireno[8,8a]azuleno[4,5-b]furan-8(4aH)-one, 5,6,6a,7,9a,9b-hexahydro-1,4a-dimethyl-7-methylene-, (3aS,4aR,6aS,9aS,9bR)-

CAS No: 137624-14-7 Catalog No: AG0013N5 MDL No:

Product Description

Catalog Number:
AG0013N5
Chemical Name:
3H-Oxireno[8,8a]azuleno[4,5-b]furan-8(4aH)-one, 5,6,6a,7,9a,9b-hexahydro-1,4a-dimethyl-7-methylene-, (3aS,4aR,6aS,9aS,9bR)-
CAS Number:
137624-14-7
IUPAC Name:
(1S,3R,6S,10S,11R)-3,12-dimethyl-7-methylidene-2,9-dioxatetracyclo[9.3.0.01,3.06,10]tetradec-12-en-8-one
InChI:
InChI=1S/C15H18O3/c1-8-4-7-15-11(8)12-10(9(2)13(16)17-12)5-6-14(15,3)18-15/h4,10-12H,2,5-7H2,1,3H3/t10-,11+,12-,14+,15-/m0/s1
InChI Key:
UVJYAKBJSGRTHA-OEMOEHNSSA-N

Properties

Complexity:
506  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Defined Bond Stereocenter Count:
0
Exact Mass:
246.126g/mol
Formal Charge:
0
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
246.306g/mol
Monoisotopic Mass:
246.126g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
38.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.7  

Literature

Title Journal
Guaianolide sesquiterpene lactones, a source to discover agents that selectively inhibit acute myelogenous leukemia stem and progenitor cells. Journal of medicinal chemistry 20121025
Biomimetic semisynthesis of arglabin from parthenolide. The Journal of organic chemistry 20120817
Synthesis and biological evaluation of antitumor-active arglabin derivatives. Archiv der Pharmazie 20120301
[Problems in the current target therapy of malignancies]. Voprosy onkologii 20050101
[Anti-inflammatory effect of arglabin and 11,13-dihydro-13-dimethylaminoarglabin hydrochloride]. Eksperimental'naia i klinicheskaia farmakologiia 20040101
Arglabin-DMA, a plant derived sesquiterpene, inhibits farnesyltransferase. Oncology reports 20010101

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