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CAS No: 13739-02-1 Catalog No: AG00138E MDL No:MFCD00468030
Title | Journal |
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Diacerein decreases visceral pain through inhibition of glutamatergic neurotransmission and cytokine signaling in mice. | Pharmacology, biochemistry, and behavior 20121001 |
Bone-targeting glycol and NSAIDS ester prodrugs of rhein: synthesis, hydroxyapatite affinity, stability, anti-inflammatory, ulcerogenicity index and pharmacokinetics studies. | European journal of medicinal chemistry 20120901 |
Nutraceuticals in the management of osteoarthritis : a critical review. | Drugs & aging 20120901 |
Diacerein: a potential therapeutic drug for periodontal disease. | Medical hypotheses 20120801 |
[Clinical study of Qianggu granule and diacerein capsule in treating knee osteoarthritis]. | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20120601 |
[Management of osteoarthritis: oral therapies]. | La Revue du praticien 20120501 |
Comment on: Ramos-Zavala et al. Effect of diacerein on insulin secretion and metabolic control in drug-naïve patients with type 2 diabetes: a randomized clinical trial. Diabetes Care 2011;34:1591-1594. | Diabetes care 20120201 |
Diacerein as adjuvant to diclofenac sodium in osteoarthritis knee. | International journal of rheumatic diseases 20120201 |
[Clinical efficacy of bushen huoxue qubi decoction on treatment of knee-osteoarthritis and its effect on hemarheology, anti-inflammation and antioxidation]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120201 |
A comparison of the therapeutic efficacy of diclofenac in osteoarthritis: a systematic review of randomised controlled trials. | Current medical research and opinion 20120101 |
Effect of the Japanese herbal medicine, Boiogito, on the osteoarthritis of the knee with joint effusion. | Sports medicine, arthroscopy, rehabilitation, therapy & technology : SMARTT 20120101 |
Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health. | International journal of molecular sciences 20120101 |
Fast-dissolving and high-drug-loaded, Fatty Acid-based self-emulsifying solid dispersions of diacerein. | PDA journal of pharmaceutical science and technology 20120101 |
Combined effect of subchondral drilling and hyaluronic acid with/without diacerein in full-thickness articular cartilage lesion in rabbits. | TheScientificWorldJournal 20120101 |
Rhein: a potential biological therapeutic drug for intervertebral disc degeneration. | Medical hypotheses 20111201 |
Diacerhein improves glucose tolerance and insulin sensitivity in mice on a high-fat diet. | Endocrinology 20111101 |
Physicochemical characterization and dissolution study of solid dispersions of diacerein with polyethylene glycol 6000. | Drug development and industrial pharmacy 20111001 |
Effect of diacerein on insulin secretion and metabolic control in drug-naive patients with type 2 diabetes: a randomized clinical trial. | Diabetes care 20110701 |
Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI. | Annals of the rheumatic diseases 20110601 |
Stability-indicating spectrophotometric and spectrodensitometric methods for the determination of diacerein in the presence of its degradation product. | Drug testing and analysis 20110401 |
Argirein alleviates diabetic nephropathy through attenuating NADPH oxidase, Cx43, and PERK in renal tissue. | Naunyn-Schmiedeberg's archives of pharmacology 20110301 |
Changes of body weight and inflammatory markers after 12-week intervention trial: results of a double-blind, placebo-control pilot study. | Yonsei medical journal 20110301 |
Lyprinol-is it a useful anti-inflammatory agent? | Evidence-based complementary and alternative medicine : eCAM 20110101 |
Comparison of general practitioners and rheumatologists' prescription patterns for patients with knee osteoarthritis. | BMC musculoskeletal disorders 20110101 |
Prescription patterns and appropriateness of NSAID therapy according to gastrointestinal risk and cardiovascular history in patients with diagnoses of osteoarthritis. | BMC medicine 20110101 |
A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis. | Arthritis research & therapy 20110101 |
T'ai chi for the treatment of osteoarthritis: a systematic review and meta-analysis. | BMJ open 20110101 |
[Pharmacological therapies for osteoarthritis]. | Therapie 20110101 |
Development and validation of simultaneous spectrophotometric methods for drotaverine hydrochloride and aceclofenac from tablet dosage form. | Indian journal of pharmaceutical sciences 20110101 |
Improvement in the dissolution profile of diacerein using a surfactant-based solid dispersion technique. | Drug discoveries & therapeutics 20101201 |
Effects of diacerein at the molecular level in the osteoarthritis disease process. | Therapeutic advances in musculoskeletal disease 20100401 |
Diacerein decreases TNF-alpha and IL-1beta levels in peritoneal fluid and prevents Baker's yeast-induced fever in young rats. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20100301 |
Symptomatic efficacy and safety of diacerein in the treatment of osteoarthritis: a meta-analysis of randomized placebo-controlled trials. | Osteoarthritis and cartilage 20100301 |
Effects of risedronate on osteoarthritis of the knee. | Yonsei medical journal 20100301 |
A peptidyl-glucosamine derivative affects IKKalpha kinase activity in human chondrocytes. | Arthritis research & therapy 20100101 |
Is Phytalgic(R) a goldmine for osteoarthritis patients or is there something fishy about this nutraceutical? A summary of findings and risk-of-bias assessment. | Arthritis research & therapy 20100101 |
Curcumin mediated suppression of nuclear factor-κB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment. | Arthritis research & therapy 20100101 |
Small study effects in meta-analyses of osteoarthritis trials: meta-epidemiological study. | BMJ (Clinical research ed.) 20100101 |
Visible spectrophotometric estimation of diacerein in bulk and pharmaceutical dosage forms. | Journal of young pharmacists : JYP 20100101 |
Efficacy and safety of diacerein in early knee osteoarthritis: a randomized placebo-controlled trial. | Clinical rheumatology 20091001 |
Anti-inflammatory and anti-peroxidative roles of diacerein are possibly mediated through an alteration in thyroid functions in animal model of inflammation. | Fundamental & clinical pharmacology 20090801 |
Self-reported prevalence of psoriasis and evaluation of the impact on the natural history of hip osteoarthritis: results of a 10 years follow-up study of 507 patients (ECHODIAH study). | Joint, bone, spine : revue du rhumatisme 20090701 |
Physico-chemical and structural characterization of diacerhein. | Journal of pharmaceutical and biomedical analysis 20090501 |
PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition. | Journal of molecular biology 20090424 |
Simultaneous HPLC-UV determination of rhein and aceclofenac in human plasma. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090415 |
Isolation and structural elucidation of two impurities from a diacerein bulk drug. | Journal of pharmaceutical and biomedical analysis 20090220 |
Comment on: comparison between chondroprotective effects of glucosamine, curcumin and diacerein in IL-1beta-stimulated C-28/I2 chondrocytes. | Osteoarthritis and cartilage 20090101 |
[Non-surgical treatment of osteoarthritis of large joints - new aspects]. | Wiener medizinische Wochenschrift (1946) 20090101 |
Rhein, the metabolite of diacerhein, reduces the proliferation of osteoarthritic chondrocytes and synoviocytes without inducing apoptosis. | Scandinavian journal of rheumatology 20090101 |
The effects of excluding patients from the analysis in randomised controlled trials: meta-epidemiological study. | BMJ (Clinical research ed.) 20090101 |
Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice. | Arthritis research & therapy 20090101 |
Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. | International journal of medical sciences 20090101 |
A stability-indicating high performance liquid chromatographic method for the determination of diacerein in capsules. | Indian journal of pharmaceutical sciences 20090101 |
A modified method for isolation of rhein from senna. | Indian journal of pharmaceutical sciences 20090101 |
[Treatment of osteoarthritis with drugs and other modalities]. | Der Internist 20081201 |
Comparison between chondroprotective effects of glucosamine, curcumin, and diacerein in IL-1beta-stimulated C-28/I2 chondrocytes. | Osteoarthritis and cartilage 20081001 |
Immune system and inflammation. | Indian journal of pharmacology 20081001 |
Prize sessions. | Indian journal of pharmacology 20081001 |
The disease modifying osteoarthritis drug (DMOAD): Is it in the horizon? | Pharmacological research 20080701 |
Diacerhein downregulate proinflammatory cytokines expression and decrease the autoimmune diabetes frequency in nonobese diabetic (NOD) mice. | International immunopharmacology 20080601 |
Diacerein has a weak effect on the catabolic pathway of human osteoarthritis synovial fibroblast--comparison to its effects on osteoarthritic chondrocytes. | Rheumatology (Oxford, England) 20080501 |
[Effectiveness of drugs used in degenerative joint diseases (arthroses)]. | Medicina clinica 20080405 |
OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. | Osteoarthritis and cartilage 20080201 |
Intra-articular hyaluronic acid for treatment of osteoarthritis: a nationwide study among the older population of Taiwan. | BMC health services research 20080101 |
The effectiveness of pulsed electrical stimulation (E-PES) in the management of osteoarthritis of the knee: a protocol for a randomised controlled trial. | BMC musculoskeletal disorders 20080101 |
In vitro effects of diacerein on NO production by chondrocytes in response to proinflammatory mediators. | Bio-medical materials and engineering 20080101 |
Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling. | Arthritis research & therapy 20080101 |
Clinical review of chondroitin sulfate in osteoarthritis. | Osteoarthritis and cartilage 20080101 |
Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis. | Arthritis research & therapy 20080101 |
An open prospective study on postmarketing evaluation of the efficacy and tolerability of diacerein in osteo-arthritis of the knee (DOK). | Journal of the Indian Medical Association 20080101 |
Bioequivalence study of two capsule formulations containing diacerein 50 mg in healthy human subjects. | Arzneimittel-Forschung 20080101 |
In vitro inhibition of IL-1beta catabolic effects on cartilage: a mechanism involved on diacerein anti-OA properties. | Biorheology 20080101 |
P38 MAP kinase inhibitors as potential therapeutics for the treatment of joint degeneration and pain associated with osteoarthritis. | Journal of inflammation (London, England) 20080101 |
Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system. | BMC musculoskeletal disorders 20080101 |
The efficacy and safety of diacerein in the treatment of painful osteoarthritis of the knee: a randomized, multicenter, double-blind, placebo-controlled study with primary end points at two months after the end of a three-month treatment period. | Arthritis and rheumatism 20071201 |
[Review of the evidence about drugs used as SYSADOA]. | Medicina clinica 20071103 |
Nutraceuticals in the management of osteoarthritis. | Orthopedics 20070801 |
The efficacy, safety and carry-over effect of diacerein in the treatment of painful knee osteoarthritis: a randomised, double-blind, NSAID-controlled study. | Osteoarthritis and cartilage 20070601 |
Review: diacerein is more effective than placebo and is as effective as NSAIDs for knee and hip osteoarthritis. | Evidence-based medicine 20070601 |
Selection of reliable reference genes for qPCR studies on chondroprotective action. | BMC molecular biology 20070101 |
DMOAD developments: present and future. | Bulletin of the NYU hospital for joint diseases 20070101 |
A critical appraisal of guidelines for the management of knee osteoarthritis using Appraisal of Guidelines Research and Evaluation criteria. | Arthritis research & therapy 20070101 |
Diacerhein versus glucosamine in a rat model of osteoarthritis. | Clinics (Sao Paulo, Brazil) 20061001 |
A meta-analysis of controlled clinical studies with diacerein in the treatment of osteoarthritis. | Archives of internal medicine 20060925 |
Effect of oral diacerein (DAR) in an experimental hip chondrolysis model. | Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20060601 |
Evaluation of efficacy and safety of diacerein in knee osteoarthritis in Chinese patients. | Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 20060601 |
[Inhibitory effect of diacerein on osteoclastic bone destruction and its possible mechanism of action]. | Yao xue xue bao = Acta pharmaceutica Sinica 20060601 |
Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
Molecular markers of cartilage breakdown and synovitis at baseline as predictors of structural progression of hip osteoarthritis. The ECHODIAH Cohort. | Annals of the rheumatic diseases 20060301 |
Diacerein for osteoarthritis. | The Cochrane database of systematic reviews 20060125 |
Most recent developments in strategies to reduce the progression of structural changes in osteoarthritis: today and tomorrow. | Arthritis research & therapy 20060101 |
Inhibition of interleukin-1beta-induced activation of MEK/ERK pathway and DNA binding of NF-kappaB and AP-1: potential mechanism for Diacerein effects in osteoarthritis. | Biorheology 20060101 |
IL-1beta synthesis by chondrocyte analyzed by 3D microscopy and flow cytometry: effect of Rhein. | Biorheology 20060101 |
The effects of diacerhein on mechanical allodynia in inflammatory and neuropathic models of nociception in mice. | Anesthesia and analgesia 20051201 |
Osteoarthritis: an overview of the disease and its treatment strategies. | Seminars in arthritis and rheumatism 20050801 |
[Pharmacological treatment of osteoarthritis. Expectations and reality]. | Revista clinica espanola 20050401 |
Future treatment of osteoarthritis. | Orthopedics 20050201 |
Subjective impact of osteoarthritis flare-ups on patients' quality of life. | Health and quality of life outcomes 20050101 |
Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis. | Arthritis research & therapy 20050101 |
Expedient total syntheses of rhein and diacerhein via Fries rearrangement. | The Journal of organic chemistry 20041210 |
Evaluation of the symptomatic and structural efficacy of a new hyaluronic acid compound, NRD101, in comparison with diacerein and placebo in a 1 year randomised controlled study in symptomatic knee osteoarthritis. | Annals of the rheumatic diseases 20041201 |
[Total hip arthroplasty indication, evaluation criteria for structure modifying trials. Lessons from the ECHODIAH and PHARE studies]. | Presse medicale (Paris, France : 1983) 20040522 |
[Mechanisms of action of diacerein, the first inhibitor of interleukin-1 in osteoarthritis]. | Presse medicale (Paris, France : 1983) 20040522 |
Recommendations for the use of new methods to assess the efficacy of disease-modifying drugs in the treatment of osteoarthritis. | Osteoarthritis and cartilage 20040401 |
[Chondromodulation in 2003: dream or reality?]. | Revue medicale de la Suisse romande 20040201 |
Measurement of structure (disease) modification in osteoarthritis. | Osteoarthritis and cartilage 20040101 |
Effect of phospholipase A2 inhibitory peptide on inflammatory arthritis in a TNF transgenic mouse model: a time-course ultrastructural study. | Arthritis research & therapy 20040101 |
Similar group mean scores, but large individual variations, in patient-relevant outcomes over 2 years in meniscectomized subjects with and without radiographic knee osteoarthritis. | Health and quality of life outcomes 20040101 |
Diacerein has a structure/disease-modifying effect on hip osteoarthritis. | Clinical and experimental rheumatology 20040101 |
New perspectives in the management of osteoarthritis. structure modification: facts or fantasy? | The Journal of rheumatology. Supplement 20030801 |
The true results of the ECHODIAH study with diacerein. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20030501 |
Diacerein reduces the level of cartilage chondrocyte DNA fragmentation and death in experimental dog osteoarthritic cartilage at the same time that it inhibits caspase-3 and inducible nitric oxide synthase. | Clinical and experimental rheumatology 20030101 |
Long-term treatment with diacerein has a structure/disease modifying effect on hip osteoarthritis. | Clinical and experimental rheumatology 20030101 |
[Efficacy of diacerein on the symptoms and radiographic progression of osteoarthritis]. | Presse medicale (Paris, France : 1983) 20021207 |
[Comparison of the pharmacologic effect of diacerein and a selective COX-2 inhibitor in the mouse induced-granuloma model]. | Presse medicale (Paris, France : 1983) 20021207 |
[Clinical and radiographic status of patients in the ECHODIAH study who underwent THA Pertinence of the pain-function index for operative decision making]. | Presse medicale (Paris, France : 1983) 20021207 |
Oral and intra-articular remedies: Review of papers published from March 2001 to February 2002. | Current opinion in rheumatology 20020901 |
Response of young, aged and osteoarthritic human articular chondrocytes to inflammatory cytokines: molecular and cellular aspects. | Matrix biology : journal of the International Society for Matrix Biology 20020801 |
Pharmacological studies of diacerein in animal models of inflammation, arthritis and bone resorption. | European journal of pharmacology 20020712 |
Diacerhein and rhein prevent interleukin-1beta-induced nuclear factor-kappaB activation by inhibiting the degradation of inhibitor kappaB-alpha. | Pharmacology & toxicology 20020701 |
[Current therapeutic possibilities in the treatment of arthrosis]. | La Revue du praticien 20020301 |
[Current medical possibilities in the treatment of arthrosis]. | Presse medicale (Paris, France : 1983) 20020112 |
[Results of the ECHODIAH clinical trial on hip arthrosis]. | Presse medicale (Paris, France : 1983) 20020112 |
In vitro study of intracellular IL-1beta production and beta1 integrins expression in stimulated chondrocytes--effect of rhein. | Biorheology 20020101 |
Diacerein as a disease-modulating agent in osteoarthritis. | Current rheumatology reports 20011201 |
Evaluation of the structure-modifying effects of diacerein in hip osteoarthritis: ECHODIAH, a three-year, placebo-controlled trial. Evaluation of the Chondromodulating Effect of Diacerein in OA of the Hip. | Arthritis and rheumatism 20011101 |
Retrospective analysis of drug-induced urticaria and angioedema: a survey of 2287 patients. | Immunopharmacology and immunotoxicology 20011101 |
Pharmacological therapy of osteoarthritis. | Best practice & research. Clinical rheumatology 20011001 |
Diacerein suppresses the increase in plasma nitric oxide in rat adjuvant-induced arthritis. | European journal of pharmacology 20010511 |
A novel microassay for the quantitation of the sulfated glycosaminoglycan content of histological sections: its application to determine the effects of Diacerhein on cartilage in an ovine model of osteoarthritis. | Osteoarthritis and cartilage 20010401 |
Rhein, an active metabolite of diacerein, down-regulates the production of pro-matrix metalloproteinases-1, -3, -9 and -13 and up-regulates the production of tissue inhibitor of metalloproteinase-1 in cultured rabbit articular chondrocytes. | Osteoarthritis and cartilage 20010401 |
Diacerein reduces the excess synthesis of bone remodeling factors by human osteoblast cells from osteoarthritic subchondral bone. | The Journal of rheumatology 20010401 |
The effects of orally administered diacerein on cartilage and subchondral bone in an ovine model of osteoarthritis. | The Journal of rheumatology 20010401 |
Pharmacologic pain treatment of musculoskeletal disorders: current perspectives and future prospects. | The Clinical journal of pain 20010301 |
Reports of equivalence trials should not mask negative or mediocre results. | Joint, bone, spine : revue du rhumatisme 20010301 |
[Pharmacy clinics. How I treat...Osteoarthritis. 2nd part: new therapeutic perspectives]. | Revue medicale de Liege 20010301 |
Rhein, an active metabolite of diacerein, suppresses the interleukin-1alpha-induced proteoglycan degradation in cultured rabbit articular chondrocytes. | Japanese journal of pharmacology 20010101 |
[Case report of fatal hepatitis from diacerein]. | Therapie 20010101 |
Effects of diacerein on indomethacin-induced gastric ulceration. | Pharmacology 20010101 |
Diacerhein and rhein reduce the ICE-induced IL-1beta and IL-18 activation in human osteoarthritic cartilage. | Osteoarthritis and cartilage 20000501 |
Sleep attacks and Parkinson's disease treatment. | Lancet (London, England) 20000415 |
Clinical pharmacokinetics of diacerein. | Clinical pharmacokinetics 19981101 |
Excretion and distribution of [14C]rhein and [14C]rhein anthrone in rat. | The Journal of pharmacy and pharmacology 19880901 |
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