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137018-55-4 | 2H-1-Benzopyran-6-ol, 2-[[4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]methyl]-3,4-dihydro-2,5,7,8-tetramethyl-, hydrochloride (1:2), (2R)-
CAS No: 137018-55-4 Catalog No: AG0012PE MDL No:
Product Description
Catalog Number:
AG0012PE
Chemical Name:
2H-1-Benzopyran-6-ol, 2-[[4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]methyl]-3,4-dihydro-2,5,7,8-tetramethyl-, hydrochloride (1:2), (2R)-
CAS Number:
137018-55-4
Molecular Formula:
C30H46Cl2N6O2
Molecular Weight:
593.6312
IUPAC Name:
2-[[4-(2,6-dipyrrolidin-1-ylpyrimidin-4-yl)piperazin-1-yl]methyl]-2,5,7,8-tetramethyl-3,4-dihydrochromen-6-ol;dihydrochloride
InChI:
InChI=1S/C30H44N6O2.2ClH/c1-21-22(2)28-24(23(3)27(21)37)9-10-30(4,38-28)20-33-15-17-35(18-16-33)26-19-25(34-11-5-6-12-34)31-29(32-26)36-13-7-8-14-36;;/h19,37H,5-18,20H2,1-4H3;2*1H
InChI Key:
KJGXSMZHYBXPIS-UHFFFAOYSA-N
SMILES:
Cc1c(C)c2OC(C)(CCc2c(c1O)C)CN1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1.Cl.Cl
Properties
Complexity:
783
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
592.306g/mol
Formal Charge:
0
Heavy Atom Count:
40
Hydrogen Bond Acceptor Count:
8
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
593.638g/mol
Monoisotopic Mass:
592.306g/mol
Rotatable Bond Count:
5
Topological Polar Surface Area:
68.2A^2
Undefined Atom Stereocenter Count:
1
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| U83836E inhibits retinal neurodegeneration in early-stage streptozotocin-induced diabetic rats. | Ophthalmic research 20110101 |
| Mitochondrial protection after traumatic brain injury by scavenging lipid peroxyl radicals. | Journal of neurochemistry 20100701 |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
| Role of oxidative stress and caspase 3 in CD47-mediated neuronal cell death. | Journal of neurochemistry 20090101 |
| In vitro efficacy of three lazaroids in a model of acute chemical neuronal hypoxia. | Neuroscience letters 20061023 |
| Effects of U83836E on nerve functions, hyperalgesia and oxidative stress in experimental diabetic neuropathy. | Life sciences 20060717 |
| Cadmium-induced apoptosis in rat kidney epithelial cells involves decrease in nuclear factor-kappa B activity. | Toxicological sciences : an official journal of the Society of Toxicology 20060501 |
| Neuroprotection with methylaminochroman and lazaroid of embryonic ventral mesencephalic tegmental dopaminergic neurons in cold storage. | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20060501 |
| Lazaroid U-83836E improves tolerance to hemorrhagic shock and limb ischemia and reperfusion in rats and increases cardiac heat shock protein 72. | Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 20060101 |
| Neonatal alcohol exposure increases malondialdehyde (MDA) and glutathione (GSH) levels in the developing cerebellum. | Brain research. Developmental brain research 20051207 |
| Antioxidant pretreatment does not ameliorate alcohol-induced Purkinje cell loss in the developing rat cerebellum. | Alcoholism, clinical and experimental research 20050701 |
| MgSO4 and lazaroid (U-83836E) partially protects glioma cells against glutamate toxicity in vitro. | Acta neurobiologiae experimentalis 20040101 |
| A2E-epoxides damage DNA in retinal pigment epithelial cells. Vitamin E and other antioxidants inhibit A2E-epoxide formation. | The Journal of biological chemistry 20030516 |
| Lazaroid attenuates edema by stabilizing ATPase in the traumatized rat brain. | The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20030501 |
| Involvement of the mitochondrial pathway in cold storage and rewarming-associated apoptosis of human renal proximal tubular cells. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20030301 |
| Comparison between survival of lazaroid-treated embryonic nigral neurons in cell suspensions, cultures and transplants. | Brain research 20021115 |
| Nitronyl nitroxides, a novel group of protective agents against oxidative stress in endothelial cells forming the blood-brain barrier. | Neuropharmacology 20021101 |
| Role of mitochondrial complexes I and II, reactive oxygen species and arachidonic acid metabolism in deoxycholate-induced apoptosis. | Cancer letters 20020328 |
| Effects of antioxidant pretreatment on the survival of embryonic dopaminergic neurons in vitro and following grafting in an animal model of Parkinson's disease. | Cell transplantation 20020101 |
| Lazaroid compounds prevent early but not late stages of oxidant-induced cell injury: potential explanation for the lack of efficacy of lazaroids in clinical trials. | Pharmacological research 20010101 |
| Cardiotoxicity of doxorubicin: effects of 21-aminosteroids. | Life sciences 19980101 |
| Diisopropylphosphorofluoridate-induced muscle hyperactivity associated with enhanced lipid peroxidation in vivo. | Biochemical pharmacology 19960726 |
| Canine in vivo tracheal chemotaxis of eosinophils to antigen in sensitized dogs: inhibition by a steroid, a systemic lazaroid U-78517F, and several topical H1 antihistamines. | The American review of respiratory disease 19920901 |
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