CAS 133343-34-7 | L-Cysteine, N-acetyl-S-[(3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-D-prolyl]- | CAS Number 133343-34-7

Title	Journal
Arsenic-induced apoptosis in the p53-proficient and p53-deficient cells through differential modulation of NFkB pathway.	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20180801
Compensatory role of the Nrf2-ARE pathway against paraquat toxicity: Relevance of 26S proteasome activity.	Journal of pharmacological sciences 20151101
The Food-Associated Ribotoxin Deoxynivalenol Modulates Inducible NO Synthase in Human Intestinal Cell Model.	Toxicological sciences : an official journal of the Society of Toxicology 20150601
Beta catenin is degraded by both caspase-3 and proteasomal activity during resveratrol-induced apoptosis in HeLa cells in a GSK3β-independent manner.	Indian journal of biochemistry & biophysics 20150201
Resveratrol promotes degradation of the human bile acid transporter ASBT (SLC10A2).	The Biochemical journal 20140415
Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor.	The Biochemical journal 20140215
Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells.	PloS one 20140101
Forskolin stimulation promotes urea transporter UT-A1 ubiquitination, endocytosis, and degradation in MDCK cells.	American journal of physiology. Renal physiology 20121101
Δ⁹-tetrahydrocannabinol (Δ⁹-THC) exerts a direct neuroprotective effect in a human cell culture model of Parkinson's disease.	Neuropathology and applied neurobiology 20121001
Chaperones, but not oxidized proteins, are ubiquitinated after oxidative stress.	Free radical biology & medicine 20121001
Proteasome inhibition decreases inflammation in human endothelial cells exposed to lipopolysaccharide.	Journal of cardiovascular pharmacology 20121001
[Enhanced activation of T lymphocytes by urease-deficient recombinant bacillus Calmette-Guérin producing heat shock protein 70-major membrane protein-II fusion protein].	Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association 20120901
Expression of the ubiquitin proteasome system in neonatal rat gonocytes and spermatogonia: role in gonocyte differentiation.	Biology of reproduction 20120801
Laminin-111 stimulates proliferation of mouse embryonic stem cells through a reduction of gap junctional intercellular communication via RhoA-mediated Cx43 phosphorylation and dissociation of Cx43/ZO-1/drebrin complex.	Stem cells and development 20120720
Ubiquitin-proteasome system inhibitors and AMPK regulation in hepatic cold ischaemia and reperfusion injury: possible mechanisms.	Clinical science (London, England : 1979) 20120701
Lys(203) and Lys(382) are essential for the proteasomal degradation of BACE1.	Current Alzheimer research 20120601
Differential degradation of full-length and cleaved ataxin-7 fragments in a novel stable inducible SCA7 model.	Journal of molecular neuroscience : MN 20120601
Increased expression of α-synuclein by SNCA duplication is associated with resistance to toxic stimuli.	Journal of molecular neuroscience : MN 20120601
Diltiazem enhances the apoptotic effects of proteasome inhibitors to induce prostate cancer cell death.	The Journal of pharmacology and experimental therapeutics 20120601
The effect of the NF-kappa B inhibitors curcumin and lactacystin on myogenic differentiation of rhabdomyosarcoma cells.	Differentiation; research in biological diversity 20120601
The regulation of N-terminal Huntingtin (Htt552) accumulation by Beclin1.	Acta pharmacologica Sinica 20120601
Diphenylarsinic acid promotes degradation of glutaminase C by mitochondrial Lon protease.	The Journal of biological chemistry 20120525
Human tau may modify glucocorticoids-mediated regulation of cAMP-dependent kinase and phosphorylated cAMP response element binding protein.	Neurochemical research 20120501
P53 and the proteasome regulate androgen receptor activity.	Cancer biology & therapy 20120501
High sensitivity of embryonic stem cells to proteasome inhibitors correlates with low expression of heat shock protein and decrease of pluripotent cell marker expression.	BMB reports 20120501
Design and synthesis of naphthoquinone derivatives as antiproliferative agents and 20S proteasome inhibitors.	Bioorganic & medicinal chemistry letters 20120415
The plasma membrane redox enzyme NQO1 sustains cellular energetics and protects human neuroblastoma cells against metabolic and proteotoxic stress.	Age (Dordrecht, Netherlands) 20120401
Effects of phosphatase and proteasome inhibitors on Borealin phosphorylation and degradation.	Journal of biochemistry 20120401
A critical role for the inducible proteasomal subunits LMP7 and MECL1 in cytokine production by activated murine splenocytes.	Pharmacology 20120401
Proteasomal inhibition restores biological function of mis-sense mutated dysferlin in patient-derived muscle cells.	The Journal of biological chemistry 20120323
Met kinase-dependent loss of the E3 ligase Cbl in gastric cancer.	The Journal of biological chemistry 20120309
TWEAK causes myotube atrophy through coordinated activation of ubiquitin-proteasome system, autophagy, and caspases.	Journal of cellular physiology 20120301
Modeling mitochondrial dysfunctions in the brain: from mice to men.	Journal of inherited metabolic disease 20120301
Identification of HSP90 as a new GABARAPL1 (GEC1)-interacting protein.	Biochimie 20120301
Presenilin-2 regulates the degradation of RBP-Jk protein through p38 mitogen-activated protein kinase.	Journal of cell science 20120301
An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid.	Nature communications 20120221
Peroxisome proliferator-activated receptor-γ activation reduces cyclooxygenase-2 expression in vascular smooth muscle cells from hypertensive rats by interfering with oxidative stress.	Journal of hypertension 20120201
Viral mediated redirection of NEMO/IKKγ to autophagosomes curtails the inflammatory cascade.	PLoS pathogens 20120201
p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells.	PLoS biology 20120201
The peptidases of Trypanosoma cruzi: digestive enzymes, virulence factors, and mediators of autophagy and programmed cell death.	Biochimica et biophysica acta 20120101
Janus kinase 2--a novel negative regulator of estrogen receptor α function.	Cellular signalling 20120101
Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1.	The Biochemical journal 20120101
gp130 cytokines stimulate proteasomal degradation of tyrosine hydroxylase via extracellular signal regulated kinases 1 and 2.	Journal of neurochemistry 20120101
Chromatin remodelling protein SMAR1 inhibits p53 dependent transactivation by regulating acetyl transferase p300.	The international journal of biochemistry & cell biology 20120101
Effects of proteasome inhibitors on the nucleolar size of porcine oocytes.	The Journal of reproduction and development 20120101
Functional processing of nuclear Ca2+/calmodulin-dependent protein kinase phosphatase (CaMKP-N): evidence for a critical role of proteolytic processing in the regulation of its catalytic activity, subcellular localization and substrate targeting in vivo.	Archives of biochemistry and biophysics 20120101
M30, a brain permeable multitarget neurorestorative drug in post nigrostriatal dopamine neuron lesion of parkinsonism animal models.	Parkinsonism & related disorders 20120101
Trafficking-deficient G572R-hERG and E637K-hERG activate stress and clearance pathways in endoplasmic reticulum.	PloS one 20120101
Human papillomavirus 18 E6 inhibits phosphorylation of p53 expressed in HeLa cells.	Cell & bioscience 20120101
Imbalance of neurotrophin receptor isoforms TrkB-FL/TrkB-T1 induces neuronal death in excitotoxicity.	Cell death & disease 20120101
Translation of MMTV Gag requires nuclear events involving splicing motifs in addition to the viral Rem protein and RmRE.	Retrovirology 20120101
Mammalian ste20-like kinase and SAV1 promote 3T3-L1 adipocyte differentiation by activation of PPARγ.	PloS one 20120101
Protein carbonylation and aggregation precede neuronal apoptosis induced by partial glutathione depletion.	ASN neuro 20120101
Internalization and down-regulation of the ALK receptor in neuroblastoma cell lines upon monoclonal antibodies treatment.	PloS one 20120101
Role of the cellular prion protein in oligodendrocyte precursor cell proliferation and differentiation in the developing and adult mouse CNS.	PloS one 20120101
Differential regulation of cutaneous oncoprotein HPVE6 by wtp53, mutant p53R248W and ΔNp63α is HPV type dependent.	PloS one 20120101
Parkinson's disease DJ-1 L166P alters rRNA biogenesis by exclusion of TTRAP from the nucleolus and sequestration into cytoplasmic aggregates via TRAF6.	PloS one 20120101
Engagement of ubiquitination and de-ubiquitination at rostral ventrolateral medulla in experimental brain death.	Journal of biomedical science 20120101
Lipopolysaccharide-induced neuroinflammation leads to the accumulation of ubiquitinated proteins and increases susceptibility to neurodegeneration induced by proteasome inhibition in rat hippocampus.	Journal of neuroinflammation 20120101
Escape from the Phagosome: The Explanation for MHC-I Processing of Mycobacterial Antigens?	Frontiers in immunology 20120101
Cross-presentation of cell-associated antigens by mouse splenic dendritic cell populations.	Frontiers in immunology 20120101
Nicotinic acetylcholine receptor agonists attenuate septic acute kidney injury in mice by suppressing inflammation and proteasome activity.	PloS one 20120101
Phosphorylation of nicastrin by SGK1 leads to its degradation through lysosomal and proteasomal pathways.	PloS one 20120101
MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I interferon production after activation of the antiviral RIG-I-like receptors.	BMC biology 20120101
Fibroblast growth factor signaling potentiates VE-cadherin stability at adherens junctions by regulating SHP2.	PloS one 20120101
Novel strategies for immunotherapy in multiple myeloma: previous experience and future directions.	Clinical & developmental immunology 20120101
AMPA receptor trafficking in homeostatic synaptic plasticity: functional molecules and signaling cascades.	Neural plasticity 20120101
Estrogen and progesterone regulate p27kip1 levels via the ubiquitin-proteasome system: pathogenic and therapeutic implications for endometrial cancer.	PloS one 20120101
Release of Full-Length PrP(C) from Cultured Neurons Following Neurotoxic Challenges.	Frontiers in neurology 20120101
γ-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1.	The Journal of biological chemistry 20111209
p53-Independent up-regulation of a TRAIL receptor DR5 by proteasome inhibitors: a mechanism for proteasome inhibitor-enhanced TRAIL-induced apoptosis.	Biochemical and biophysical research communications 20111209
Proteasome inhibitors induce apoptosis and reduce viral replication in primary effusion lymphoma cells.	Biochemical and biophysical research communications 20111202
Neuroprotective effects of MAPK/ERK1/2 and calpain inhibitors on lactacystin-induced cell damage in primary cortical neurons.	Neurotoxicology 20111201
Proteasome inhibitor lactacystin augments natural killer cell cytotoxicity of myeloma via downregulation of HLA class I.	Biochemical and biophysical research communications 20111111
TRAIL promotes caspase-dependent pro-inflammatory responses via PKCδ activation by vascular smooth muscle cells.	Cell death & disease 20111101
Stereospecific total syntheses of proteasome inhibitors omuralide and lactacystin.	The Journal of organic chemistry 20111021
P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium/calpain-dependent mechanism.	Oncogene 20111013
Protection of neuronal calcium sensor 1 protein in cells treated with paclitaxel.	The Journal of biological chemistry 20111007
Nrf2/HO-1 pathway activation by manganese is associated with reactive oxygen species and ubiquitin-proteasome pathway, not MAPKs signaling.	Journal of applied toxicology : JAT 20111001
Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease.	British journal of pharmacology 20111001
New betulinic acid derivatives as potent proteasome inhibitors.	Bioorganic & medicinal chemistry letters 20111001
Chlamydia trachomatis co-opts the FGF2 signaling pathway to enhance infection.	PLoS pathogens 20111001
RB1CC1 protein positively regulates transforming growth factor-beta signaling through the modulation of Arkadia E3 ubiquitin ligase activity.	The Journal of biological chemistry 20110916
The human papillomavirus E6 oncogene represses a cell adhesion pathway and disrupts focal adhesion through degradation of TAp63β upon transformation.	PLoS pathogens 20110901
Targeting of a chlamydial protease impedes intracellular bacterial growth.	PLoS pathogens 20110901
Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta.	The Journal of biological chemistry 20110819
[Expression and regulation of androgen receptor in the androgen-independent conversion of prostate cancer cells].	Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20110818
Crosstalk between Nodal/activin and MAPK p38 signaling is essential for anterior-posterior axis specification.	Current biology : CB 20110809
Changes in iron-regulatory gene expression occur in human cell culture models of Parkinson's disease.	Neurochemistry international 20110801
Leishmania donovani: proteasome-mediated down-regulation of methionine adenosyltransferase.	Parasitology 20110801
The Parkinson's disease protein LRRK2 impairs proteasome substrate clearance without affecting proteasome catalytic activity.	Cell death & disease 20110801
Beta-HPV 5 and 8 E6 promote p300 degradation by blocking AKT/p300 association.	PLoS pathogens 20110801
γ-Hydroxy-1,N2-propano-2'-deoxyguanosine DNA adduct conjugates the N-terminal amine of the KWKK peptide via a carbinolamine linkage.	Chemical research in toxicology 20110718
Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies.	Cell biochemistry and biophysics 20110701
Proteasomal degradation of myocardin is required for its transcriptional activity in vascular smooth muscle cells.	Journal of cellular physiology 20110701
[Content of chaperon Hsp70 in dopaminergic neurons of the black substance increases in proteasome dysfunstion].	Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20110701
Valosin-containing protein gene mutations: cellular phenotypes relevant to neurodegeneration.	Journal of molecular neuroscience : MN 20110601
PDGF-induced vascular smooth muscle cell proliferation is associated with dysregulation of insulin receptor substrates.	American journal of physiology. Cell physiology 20110601
LPS-induced formation of immunoproteasomes: TNF-α and nitric oxide production are regulated by altered composition of proteasome-active sites.	Cell biochemistry and biophysics 20110601
Identification of DNA-damage DNA-binding protein 1 as a conditional essential factor for cytomegalovirus replication in interferon-γ-stimulated cells.	PLoS pathogens 20110601
Mitogen-activated protein kinase kinase 1 (MEK1) stabilizes MyoD through direct phosphorylation at tyrosine 156 during myogenic differentiation.	The Journal of biological chemistry 20110527
The role of the proteasome in the generation of MHC class I ligands and immune responses.	Cellular and molecular life sciences : CMLS 20110501
Functional 20S proteasomes in mature human red blood cells.	Experimental biology and medicine (Maywood, N.J.) 20110501
[Effect of epigallocatechin gallate on lactacystin-induced PC12 cell injury].	Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20110501
Disassembly of the JIP1/JNK molecular scaffold by caspase-3-mediated cleavage of JIP1 during apoptosis.	Experimental cell research 20110415
Semi-high throughput method of measuring proteasome inhibition in vitro and in cultured cells.	Cell biology and toxicology 20110401
Lactacystin, a proteasome inhibitor, enhances BMP-induced osteoblastic differentiation by increasing active Smads.	Biochemical and biophysical research communications 20110401
Synthesis and proteasome inhibition of lithocholic acid derivatives.	Bioorganic & medicinal chemistry letters 20110401
Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling.	Cell 20110401
The neuroprotective effect of modified Yeoldahanso-tang via autophagy enhancement in models of Parkinson's disease.	Journal of ethnopharmacology 20110324
Beta-subunits promote the expression of Ca(V)2.2 channels by reducing their proteasomal degradation.	The Journal of biological chemistry 20110318
Opioid-induced down-regulation of RGS4: role of ubiquitination and implications for receptor cross-talk.	The Journal of biological chemistry 20110311
Does 1-(R)-aminoindan possess neuroprotective properties against experimental Parkinson's disease?	Antioxidants & redox signaling 20110301
Long-term aversive taste memory requires insular and amygdala protein degradation.	Neurobiology of learning and memory 20110301
Individual caspase-10 isoforms play distinct and opposing roles in the initiation of death receptor-mediated tumour cell apoptosis.	Cell death & disease 20110301
A Pseudomonas aeruginosa toxin that hijacks the host ubiquitin proteolytic system.	PLoS pathogens 20110301
The role of monoubiquitination in endocytic degradation of human ether-a-go-go-related gene (hERG) channels under low K+ conditions.	The Journal of biological chemistry 20110225
Transcription factor IIS cooperates with the E3 ligase UBR5 to ubiquitinate the CDK9 subunit of the positive transcription elongation factor B.	The Journal of biological chemistry 20110218
Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability.	Oncogene 20110217
Processing of optineurin in neuronal cells.	The Journal of biological chemistry 20110204
Up-regulation of endoplasmic reticulum stress-related genes during the early phase of treatment of cultured cortical neurons by the proteasomal inhibitor lactacystin.	Journal of cellular physiology 20110201
Pathogenic VCP/TER94 alleles are dominant actives and contribute to neurodegeneration by altering cellular ATP level in a Drosophila IBMPFD model.	PLoS genetics 20110201
What has the study of the K3 and K5 viral ubiquitin E3 ligases taught us about ubiquitin-mediated receptor regulation?	Viruses 20110201
Tripeptidyl peptidase II serves as an alternative to impaired proteasome to maintain viral growth in the host cells.	FEBS letters 20110103
Glucocorticoid-induced activation of caspase-8 protects the glucocorticoid-induced protein Gilz from proteasomal degradation and induces its binding to SUMO-1 in murine thymocytes.	Cell death and differentiation 20110101
Wnt3a regulates tumor necrosis factor-α-stimulated interleukin-6 release in osteoblasts.	Molecular and cellular endocrinology 20110101
Environmental exposure, obesity, and Parkinson's disease: lessons from fat and old worms.	Environmental health perspectives 20110101
Toll-like receptor 4 mediates lipopolysaccharide-induced muscle catabolism via coordinate activation of ubiquitin-proteasome and autophagy-lysosome pathways.	FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110101
Inhibition of all-trans-retinoic acid-induced proteasome activation potentiates the differentiating effect of retinoid in acute myeloid leukemia cells.	Molecular carcinogenesis 20110101
β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency.	Diabetes 20110101
Regulation of posttranscriptional modification as a possible therapeutic approach for retinal neuroprotection.	Journal of ophthalmology 20110101
Effects of proteasome inhibitors on rat renal fibrosis in vitro and in vivo.	Nephrology (Carlton, Vic.) 20110101
Steroids up-regulate p66Shc longevity protein in growth regulation by inhibiting its ubiquitination.	PloS one 20110101
Perturbation with intrabodies reveals that calpain cleavage is required for degradation of huntingtin exon 1.	PloS one 20110101
The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease.	International journal of molecular sciences 20110101
Senescence marker protein 30 (SMP30) expression in eukaryotic cells: existence of multiple species and membrane localization.	PloS one 20110101
Evolution of extra-nigral damage predicts behavioural deficits in a rat proteasome inhibitor model of Parkinson's disease.	PloS one 20110101
Thiazole antibiotic thiostrepton synergize with bortezomib to induce apoptosis in cancer cells.	PloS one 20110101
Resveratrol protects leukemic cells against cytotoxicity induced by proteasome inhibitors via induction of FOXO1 and p27Kip1.	BMC cancer 20110101
Trafficking defect and proteasomal degradation contribute to the phenotype of a novel KCNH2 long QT syndrome mutation.	PloS one 20110101
A novel signaling pathway mediated by the nuclear targeting of C-terminal fragments of mammalian Patched 1.	PloS one 20110101
Photodynamic treatment induces an apoptotic pathway involving calcium, nitric oxide, p53, p21-activated kinase 2, and c-Jun N-terminal kinase and inactivates survival signal in human umbilical vein endothelial cells.	International journal of molecular sciences 20110101
Inverse baseline expression pattern of the NEP/neuropeptides and NFκB/proteasome pathways in androgen-dependent and androgen-independent prostate cancer cells.	Cancer cell international 20110101
HGF/c-met/Stat3 signaling during skin tumor cell invasion: indications for a positive feedback loop.	BMC cancer 20110101
Firefly luciferase and RLuc8 exhibit differential sensitivity to oxidative stress in apoptotic cells.	PloS one 20110101
C-terminus glycans with critical functional role in the maturation of secretory glycoproteins.	PloS one 20110101
Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neurons.	Molecular neurodegeneration 20110101
Parkin, A Top Level Manager in the Cell's Sanitation Department.	The open biochemistry journal 20110101
p21(WAF1/CIP1) upregulation through the stress granule-associated protein CUGBP1 confers resistance to bortezomib-mediated apoptosis.	PloS one 20110101
Negative regulation of interferon-β gene expression during acute and persistent virus infections.	PloS one 20110101
NOTCH-1 and NOTCH-4 are novel gene targets of PEA3 in breast cancer: novel therapeutic implications.	Breast cancer research : BCR 20110101
Analysis of proteasomal proteolysis during the in vitro metacyclogenesis of Trypanosoma cruzi.	PloS one 20110101
The p53 tumor suppressor is stabilized by inhibitor of growth 1 (ING1) by blocking polyubiquitination.	PloS one 20110101
The monoclonal antibody Zt/f2 targeting RON receptor tyrosine kinase as potential therapeutics against tumor growth-mediated by colon cancer cells.	Molecular cancer 20110101
Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways.	PloS one 20110101
Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons.	PloS one 20110101
CDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton.	PloS one 20110101
Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors.	BMC cancer 20110101
Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4.	Molecular cancer 20110101
Protein C mutation (A267T) results in ER retention and unfolded protein response activation.	PloS one 20110101
SVIP induces localization of p97/VCP to the plasma and lysosomal membranes and regulates autophagy.	PloS one 20110101
In vivo RNAi screen reveals neddylation genes as novel regulators of Hedgehog signaling.	PloS one 20110101
Human metapneumovirus inhibits IFN-β signaling by downregulating Jak1 and Tyk2 cellular levels.	PloS one 20110101
The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation.	Molecular systems biology 20110101
A ubiquitin independent degradation pathway utilized by a hepatitis B virus envelope protein to limit antigen presentation.	PloS one 20110101
Suppression of nitric oxide induction and pro-inflammatory cytokines by novel proteasome inhibitors in various experimental models.	Lipids in health and disease 20110101
The docking protein p130Cas regulates cell sensitivity to proteasome inhibition.	BMC biology 20110101
Hakai reduces cell-substratum adhesion and increases epithelial cell invasion.	BMC cancer 20110101
Substrate-favored lysosomal and proteasomal pathways participate in the normal balance control of insulin precursor maturation and disposal in β-cells.	PloS one 20110101
A double-edged sword role for ubiquitin-proteasome system in brain stem cardiovascular regulation during experimental brain death.	PloS one 20110101
Amorphous silica nanoparticles trigger nitric oxide/peroxynitrite imbalance in human endothelial cells: inflammatory and cytotoxic effects.	International journal of nanomedicine 20110101
Postnatal proteasome inhibition induces neurodegeneration and cognitive deficiencies in adult mice: a new model of neurodevelopment syndrome.	PloS one 20110101
Inhibition of nitric oxide in LPS-stimulated macrophages of young and senescent mice by δ-tocotrienol and quercetin.	Lipids in health and disease 20110101
Adriamycin enhances proteasome-mediated generation of the proapoptotic processed form of MAGE-A4 in hepatoma cells.	Oncology 20110101
The Nrf1 CNC-bZIP protein is regulated by the proteasome and activated by hypoxia.	PloS one 20110101
The promigratory activity of the matricellular protein galectin-3 depends on the activation of PI-3 kinase.	PloS one 20110101
Phosphorylated alpha-synuclein at Ser-129 is targeted to the proteasome pathway in a ubiquitin-independent manner.	The Journal of biological chemistry 20101224
Cell cycle events mediate lactacystin-induced apoptotic death of neuronal PC12 cells.	Cell biology international 20101201
Manganese-induced downregulation of astroglial glutamine transporter SNAT3 involves ubiquitin-mediated proteolytic system.	Glia 20101201
Identification of p10 as a neurotoxic product generated from the proteolytic cleavage of the neuronal Cdk5 activator.	Journal of cellular biochemistry 20101201
Metabolism and action of proteasome inhibitors in primary human hepatocytes.	Drug metabolism and disposition: the biological fate of chemicals 20101201
NleC, a type III secretion protease, compromises NF-κB activation by targeting p65/RelA.	PLoS pathogens 20101201
Phospho-ΔNp63α/Rpn13-dependent regulation of LKB1 degradation modulates autophagy in cancer cells.	Aging 20101201
Ammonium chloride and tunicamycin are novel toxins for dopaminergic neurons and induce Parkinson's disease-like phenotypes in medaka fish.	Journal of neurochemistry 20101201
TGF-β induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to generation of amyloid β plaques in Alzheimer's disease.	Cell death & disease 20101201
[Sleep changes during degeneration of neurons in the substantia nigra induced by inhibitor of proteasomes lactacystin in rats].	Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20101201
Selective susceptibility of human dopaminergic neural stem cells to dopamine-induced apoptosis.	Experimental neurobiology 20101201
Identification of a lysosomal pathway regulating degradation of the bone morphogenetic protein receptor type II.	The Journal of biological chemistry 20101126
Annexin A3 is associated with cell death in lactacystin-mediated neuronal injury.	Neuroscience letters 20101119
Enhanced activation of T lymphocytes by urease-deficient recombinant bacillus Calmette-Guérin producing heat shock protein 70-major membrane protein-II fusion protein.	Journal of immunology (Baltimore, Md. : 1950) 20101115
Fatty acids regulate CREBh via transcriptional mechanisms that are dependent on proteasome activity and insulin.	Molecular and cellular biochemistry 20101101
HTLV-1 evades type I interferon antiviral signaling by inducing the suppressor of cytokine signaling 1 (SOCS1).	PLoS pathogens 20101101
Synthesis of α-amino acids based on chiral tricycloiminolactone derived from natural (+)-camphor.	Accounts of chemical research 20101019
The proteasome regulates bacterial CpG DNA-induced signaling pathways in murine macrophages.	Shock (Augusta, Ga.) 20101001
Expression of alternatively spliced CD45 isoforms by channel catfish clonal T and B cells is dependent on activation state of the cell and regulated by protein synthesis and degradation.	Developmental and comparative immunology 20101001
Neuroprotection of pramipexole in UPS impairment induced animal model of Parkinson's disease.	Neurochemical research 20101001
Proteasome inhibition in medaka brain induces the features of Parkinson's disease.	Journal of neurochemistry 20101001
Proteasome inhibition modeling nigral neuron degeneration in Parkinson's disease.	Journal of neurochemistry 20101001
Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S beta5-subunit.	The Biochemical journal 20100915
ARRDC3 suppresses breast cancer progression by negatively regulating integrin beta4.	Oncogene 20100909
p53 Plays an important role in cell fate determination after exposure to microcystin-LR.	Environmental health perspectives 20100901
Cbl-b enhances Runx2 protein stability and augments osteocalcin promoter activity in osteoblastic cell lines.	Journal of cellular physiology 20100901
Effect of nuclear factor kappa B inhibition on L-NAME-induced hypertension and cardiovascular remodelling.	Journal of hypertension 20100901
Low levels of mutant ubiquitin are degraded by the proteasome in vivo.	Journal of neuroscience research 20100815
Novel D3 dopamine receptor-preferring agonist D-264: Evidence of neuroprotective property in Parkinson's disease animal models induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and lactacystin.	Journal of neuroscience research 20100815
Anthrax lethal toxin activates the inflammasome in sensitive rat macrophages.	Biochemical and biophysical research communications 20100806
Proapoptotic fibronectin fragment induces the degradation of ubiquitinated p53 via proteasomes in periodontal ligament cells.	Journal of periodontal research 20100801
Estrogen receptor beta signaling through phosphatase and tensin homolog/phosphoinositide 3-kinase/Akt/glycogen synthase kinase 3 down-regulates blood-brain barrier breast cancer resistance protein.	The Journal of pharmacology and experimental therapeutics 20100801
The forced aggresome formation of a bovine anion exchanger 1 (AE1) mutant through association with δF508-cystic fibrosis transmembrane conductance regulator upon proteasome inhibition in HEK293 cells.	The Japanese journal of veterinary research 20100801
Minor groove orientation of the KWKK peptide tethered via the N-terminal amine to the acrolein-derived 1,N2-gamma-hydroxypropanodeoxyguanosine lesion with a trimethylene linkage.	Biochemistry 20100727
Regulation of aurora B kinase by the lipid raft protein flotillin-1.	The Journal of biological chemistry 20100702
Determinants of CREB degradation and KChIP2 gene transcription in cardiac memory.	Heart rhythm 20100701
Hypoxic ischemia and proteasome dysfunction alter tau isoform ratio by inhibiting exon 10 splicing.	Journal of neurochemistry 20100701
Effects of Arkadia on airway remodeling through enhancing TGF-beta signaling in allergic rats.	Laboratory investigation; a journal of technical methods and pathology 20100701
Increased degradation of MYPT1 contributes to the development of tolerance to nitric oxide in porcine pulmonary artery.	American journal of physiology. Lung cellular and molecular physiology 20100701
Differential effects of lactacystin on cytokine production in activated Jurkat cells and murine splenocytes.	Cytokine 20100701
Myocardial ischemic preconditioning preserves postischemic function of the 26S proteasome through diminished oxidative damage to 19S regulatory particle subunits.	Circulation research 20100625
Ongoing DNA synthesis in the rat cerebral cortex is regulated by a proteolytic pathway independent of the proteasome and calpains.	Investigational new drugs 20100601
Detrimental effect of the proteasome inhibitor, bortezomib in bacterial superantigen- and lipopolysaccharide-induced systemic inflammation.	Molecular therapy : the journal of the American Society of Gene Therapy 20100601
The 20S proteasome splicing activity discovered by SpliceMet.	PLoS computational biology 20100601
Why do we need multifunctional neuroprotective and neurorestorative drugs for Parkinson's and Alzheimer's diseases as disease modifying agents.	Experimental neurobiology 20100601
The role of local protein synthesis and degradation in axon regeneration.	Experimental neurology 20100501
Proteasome inhibition induces hsp30 and hsp70 gene expression as well as the acquisition of thermotolerance in Xenopus laevis A6 cells.	Cell stress & chaperones 20100501
Ubiquitin/proteasome-dependent down-regulation following clathrin-mediated internalization of histamine H1-receptors in Chinese hamster ovary cells.	Journal of neurochemistry 20100501
Synergistic effect between proteasome and autophagosome in the clearance of polyubiquitinated TDP-43.	Journal of neuroscience research 20100301
Intrastriatal transplantation of GDNF-engineered BMSCs and its neuroprotection in lactacystin-induced Parkinsonian rat model.	Neurochemical research 20100301
The pattern of neuronal loss and survival may reflect differential expression of proteasome activators in Parkinson's disease.	Synapse (New York, N.Y.) 20100301
High glucose and interleukin-1beta downregulate interleukin-1 type I receptor (IL-1RI) in retinal endothelial cells by enhancing its degradation by a lysosome-dependent mechanism.	Cytokine 20100301
Effect of proteasome inhibitors with different chemical structures on the ubiquitin-proteasome system in vitro.	Veterinary pathology 20100301
Abstracts of the 16th Annual Society on NeuroImmune Pharmacology (SNIP) Conference. April 13-17, 2010. Manhattan Beach, California, USA.	Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20100301
Proteasome inhibitor lactacystin induces cholinergic degeneration.	The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20100301
E3 ligase Nedd4 promotes axon branching by downregulating PTEN.	Neuron 20100211
Genetic iron chelation protects against proteasome inhibition-induced dopamine neuron degeneration.	Neurobiology of disease 20100201
Pathogenic mutations cause rapid degradation of lysosomal storage disease-related membrane protein CLN6.	Human mutation 20100201
Hsp40 chaperones promote degradation of the HERG potassium channel.	The Journal of biological chemistry 20100129
Ischaemic preconditioning improves proteasomal activity and increases the degradation of deltaPKC during reperfusion.	Cardiovascular research 20100115
Distinct regulation of insulin receptor substrate-1 and -2 by 90-kDa heat-shock protein in adrenal chromaffin cells.	Neurochemistry international 20100101
The role of zinc in the modulation of neuronal proliferation and apoptosis.	Neurotoxicity research 20100101
Prevention of intracellular degradation of I2020T mutant LRRK2 restores its protectivity against apoptosis.	Biochemical and biophysical research communications 20100101
Translocation of lysosomal cathepsin D caused by oxidative stress or proteasome inhibition in primary cultured neurons and astrocytes.	Biological & pharmaceutical bulletin 20100101
Non-invasive evaluation of nigrostriatal neuropathology in a proteasome inhibitor rodent model of Parkinson's disease.	BMC neuroscience 20100101
Copper downregulates neprilysin activity through modulation of neprilysin degradation.	Journal of Alzheimer's disease : JAD 20100101
Activation of mutant enzyme function in vivo by proteasome inhibitors and treatments that induce Hsp70.	PLoS genetics 20100101
Bortezomib.	Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 20100101
The Caenorhabditis elegans Elongator complex regulates neuronal alpha-tubulin acetylation.	PLoS genetics 20100101
TWEAK activates the non-canonical NFkappaB pathway in murine renal tubular cells: modulation of CCL21.	PloS one 20100101
Acute NMDA toxicity in cultured rat cerebellar granule neurons is accompanied by autophagy induction and late onset autophagic cell death phenotype.	BMC neuroscience 20100101
BRCA1 as a Therapeutic Target in Sporadic Epithelial Ovarian Cancer.	Journal of oncology 20100101
Role of STAT3 in in vitro transformation triggered by TRK oncogenes.	PloS one 20100101
Degradation of postsynaptic scaffold GKAP and regulation of dendritic spine morphology by the TRIM3 ubiquitin ligase in rat hippocampal neurons.	PloS one 20100101
Changes in Activity and Kinetic Properties of the Proteasome in Different Rat Organs during Development and Maturation.	Current gerontology and geriatrics research 20100101
Role of the proteasome in excitotoxicity-induced cleavage of glutamic acid decarboxylase in cultured hippocampal neurons.	PloS one 20100101
NF-kappaB/STAT3/PI3K signaling crosstalk in iMyc E mu B lymphoma.	Molecular cancer 20100101
Cellular localization of the herpes simplex virus ICP0 protein dictates its ability to block IRF3-mediated innate immune responses.	PloS one 20100101
Cadmium induces Wnt signaling to upregulate proliferation and survival genes in sub-confluent kidney proximal tubule cells.	Molecular cancer 20100101
Acute effects of the sigma-2 receptor agonist siramesine on lysosomal and extra-lysosomal proteolytic systems in lens epithelial cells.	Molecular vision 20100101
Inhibition of hypoxia-inducible factor-1alpha (HIF-1alpha) protein synthesis by DNA damage inducing agents.	PloS one 20100101
Generating a generation of proteasome inhibitors: from microbial fermentation to total synthesis of salinosporamide a (marizomib) and other salinosporamides.	Marine drugs 20100101
Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10.	PloS one 20100101
Nucleoside drugs induce cellular differentiation by caspase-dependent degradation of stem cell factors.	PloS one 20100101
Anti-inflammatory treatment strategies for ischemia/reperfusion injury in transplantation.	Journal of inflammation (London, England) 20100101
Quercetin targets cysteine string protein (CSPalpha) and impairs synaptic transmission.	PloS one 20100101
Deletion analysis of BMI1 oncoprotein identifies its negative regulatory domain.	Molecular cancer 20100101
Cross-talk between mitochondria and proteasome in Parkinson's disease pathogenesis.	Frontiers in aging neuroscience 20100101
Endoplasmic reticulum stress response in an INS-1 pancreatic beta-cell line with inducible expression of a folding-deficient proinsulin.	BMC cell biology 20100101
Proteomic characterization of an isolated fraction of synthetic proteasome inhibitor (PSI)-induced inclusions in PC12 cells might offer clues to aggresomes as a cellular defensive response against proteasome inhibition by PSI.	BMC neuroscience 20100101
Characterization of the Brain 26S Proteasome and its Interacting Proteins.	Frontiers in molecular neuroscience 20100101
Functional characterization of the protein C A267T mutation: evidence for impaired secretion due to defective intracellular transport.	BMC cell biology 20100101
The WW-HECT protein Smurf2 interacts with the Docking Protein NEDD9/HEF1 for Aurora A activation.	Cell division 20100101
The Enigma of Tripeptidyl-Peptidase II: Dual Roles in Housekeeping and Stress.	Journal of oncology 20100101
Regulation of thromboxane receptor signaling at multiple levels by oxidative stress-induced stabilization, relocation and enhanced responsiveness.	PloS one 20100101
BRCA1 Forms a Functional Complex with γ-H2AX as a Late Response to Genotoxic Stress.	Journal of nucleic acids 20100101
Mutant INS-gene induced diabetes of youth: proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transport.	PloS one 20100101
Monomerization of cytosolic mature smac attenuates interaction with IAPs and potentiation of caspase activation.	PloS one 20100101
Treatment of breast cancer cells with proteasome inhibitor lactacystin increases the level of sensitivity to cell death induced by human immunodeficiency virus type 1.	Biological & pharmaceutical bulletin 20100101
Cell type-specific neuroprotective activity of untranslocated prion protein.	PloS one 20100101
The New Inhibitor of Monoamine Oxidase, M30, has a Neuroprotective Effect Against Dexamethasone-Induced Brain Cell Apoptosis.	Frontiers in neuroscience 20100101
Protogenin, a new member of the immunoglobulin superfamily, is implicated in the development of the mouse lower first molar.	BMC developmental biology 20100101
Deletion or insertion in the first immunoglobulin-plexin-transcription (IPT) domain differentially regulates expression and tumorigenic activities of RON receptor Tyrosine Kinase.	Molecular cancer 20100101
Proteasome inhibition and its therapeutic potential in multiple myeloma.	Biologics : targets & therapy 20100101
Probing the anticancer mechanism of prospective herbal drug Withaferin A on mammals: a case study on human and bovine proteasomes.	BMC genomics 20100101
A novel ER J-protein DNAJB12 accelerates ER-associated degradation of membrane proteins including CFTR.	Cell structure and function 20100101
Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43.	PloS one 20100101
Tocotrienols inhibit lipopolysaccharide-induced pro-inflammatory cytokines in macrophages of female mice.	Lipids in health and disease 20100101
Optimal management of cancer anorexia-cachexia syndrome.	Cancer management and research 20100101
The Relationship between Parkin and Protein Aggregation in Neurodegenerative Diseases.	Frontiers in psychiatry 20100101
Proteasome inhibition increases tau accumulation independent of phosphorylation.	Neurobiology of aging 20091201
Lysosome-dependent degradation of Notch3.	The international journal of biochemistry & cell biology 20091201
Dysfunction of the unfolded protein response increases neurodegeneration in aged rat hippocampus following proteasome inhibition.	Aging cell 20091201
Calcium-dependent plasma membrane repair requires m- or mu-calpain, but not calpain-3, the proteasome, or caspases.	Biochimica et biophysica acta 20091201
The C-terminal region of serotonin transporter is important for its trafficking and glycosylation.	Journal of pharmacological sciences 20091201
Involvement of puromycin-sensitive aminopeptidase in proteolysis of tau protein in cultured cells, and attenuated proteolysis of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) mutant tau.	Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society 20091201
[Classification and synthesis of ubiquitin-proteasome inhibitor].	Yao xue xue bao = Acta pharmaceutica Sinica 20091201
Induction of cross-priming of naive CD8+ T lymphocytes by recombinant bacillus Calmette-Guerin that secretes heat shock protein 70-major membrane protein-II fusion protein.	Journal of immunology (Baltimore, Md. : 1950) 20091115
Recessive hyperekplexia mutations of the glycine receptor alpha1 subunit affect cell surface integration and stability.	Journal of neurochemistry 20091101
z-Leucinyl-leucinyl-norleucinal induces apoptosis of human glioblastoma tumor-initiating cells by proteasome inhibition and mitotic arrest response.	Molecular cancer research : MCR 20091101
The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation.	PLoS pathogens 20091101
The proteasome is an integral part of solar ultraviolet a radiation-induced gene expression.	The Journal of biological chemistry 20091030
The microtubule-targeting agent T0070907 induces proteasomal degradation of tubulin.	Biochemical and biophysical research communications 20091016
Reactive oxygen species decrease cAMP response element binding protein expression in cardiomyocytes via a protein kinase D1-dependent mechanism that does not require Ser133 phosphorylation.	Molecular pharmacology 20091001
Lactacystin requires reactive oxygen species and Bax redistribution to induce mitochondria-mediated cell death.	British journal of pharmacology 20091001
Virus-Induced Chaperone-Enriched (VICE) domains function as nuclear protein quality control centers during HSV-1 infection.	PLoS pathogens 20091001
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.	The Journal of biological chemistry 20090911
Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling.	Journal of lipid research 20090901
The glucose transporter 2 undergoes plasma membrane endocytosis and lysosomal degradation in a secretagogue-dependent manner.	Endocrinology 20090901
Generation of dopamine neurons with improved cell survival and phenotype maintenance using a degradation-resistant nurr1 mutant.	Stem cells (Dayton, Ohio) 20090901
Limiting transport steps and novel interactions of Connexin-43 along the secretory pathway.	Histochemistry and cell biology 20090901
Role of protease inhibitors and acylation stimulating protein in the adipogenesis in 3T3-L1 cells.	Journal of veterinary science 20090901
Nuclear factor kappaB inhibitors alleviate and the proteasome inhibitor PS-341 exacerbates radiation toxicity in zebrafish embryos.	Molecular cancer therapeutics 20090901
[The role of interferon-gamma in prevention of hydrogen peroxide-induced oxidative injury to vascular endothelium].	Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20090901
A cellular model to monitor proteasome dysfunction by alpha-synuclein.	Biochemistry 20090825
[Dual effects of different concentrations of alpha-synuclein on the neurotoxicity of 6-hydroxydopamine in SH-SY5Y cells].	Sheng li xue bao : [Acta physiologica Sinica] 20090825
Size limitation in translocation of fibroblast growth factor 1 fusion proteins across the endosomal membrane.	Biochemistry 20090804
Nucleus accumbens neurons exhibit synaptic scaling that is occluded by repeated dopamine pre-exposure.	The European journal of neuroscience 20090801
Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene.	Journal of neuroscience research 20090701
An insight into the mechanistic role of p53-mediated autophagy induction in response to proteasomal inhibition-induced neurotoxicity.	Autophagy 20090701
Cyanide-induced death of dopaminergic cells is mediated by uncoupling protein-2 up-regulation and reduced Bcl-2 expression.	Toxicology and applied pharmacology 20090701
The Parkinson disease-associated A30P mutation stabilizes alpha-synuclein against proteasomal degradation triggered by heme oxygenase-1 over-expression in human neuroblastoma cells.	Journal of neurochemistry 20090701
Zinc protoporphyrin inhibition of lipopolysaccharide-, lipoteichoic acid-, and peptidoglycan-induced nitric oxide production through stimulating iNOS protein ubiquitination.	Toxicology and applied pharmacology 20090615
F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage.	Nature 20090604
Role for copper in the cellular and regulatory effects of heme-hemopexin.	Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20090601
Regulation of podoplanin/PA2.26 antigen expression in tumour cells. Involvement of calpain-mediated proteolysis.	The international journal of biochemistry & cell biology 20090601
Nedd4 mediates ErbB4 JM-a/CYT-1 ICD ubiquitination and degradation in MDCK II cells.	FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090601
Partial inhibition of proteasome activity enhances remyelination after cuprizone-induced demyelination.	Experimental neurology 20090601
The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1.	Nature cell biology 20090601
Rapamycin down-regulates inducible nitric oxide synthase by inducing proteasomal degradation.	Biological & pharmaceutical bulletin 20090601
Inhibition of lysosomal functions reduces proteasomal activity.	Neuroscience letters 20090529
Enhanced antigen presentation and CTL activity by transduction of mature rather than immature dendritic cells with octaarginine-modified liposomes.	Journal of controlled release : official journal of the Controlled Release Society 20090521
Targeting transcription factor NFkappaB: comparative analysis of proteasome and IKK inhibitors.	Cell cycle (Georgetown, Tex.) 20090515
Nicastrin is dispensable for gamma-secretase protease activity in the presence of specific presenilin mutations.	The Journal of biological chemistry 20090508
Three-dimensional structure-activity relationship study of belactosin A and its stereo- and regioisomers: development of potent proteasome inhibitors by a stereochemical diversity-oriented strategy.	Organic & biomolecular chemistry 20090507
Lactacystin stimulates stellation of cultured rat cortical astrocytes.	Neurochemical research 20090501
Characterization of proteasome inhibition on astrocytes cell cycle.	Journal of molecular neuroscience : MN 20090501
Efficacy on anaplastic thyroid carcinoma of valproic acid alone or in combination with doxorubicin, a synthetic chenodeoxycholic acid derivative, or lactacystin.	International journal of oncology 20090501
Targeting the proteasome pathway.	Expert opinion on therapeutic targets 20090501
Disruption of the ubiquitin proteasome system following axonal stretch injury accelerates progression to secondary axotomy.	Journal of neurotrauma 20090501
Regulation of the stability of cell surface E-cadherin by the proteasome.	Biochemical and biophysical research communications 20090417
Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3.	The EMBO journal 20090408
Aldosterone inhibits insulin-induced glucose uptake by degradation of insulin receptor substrate (IRS) 1 and IRS2 via a reactive oxygen species-mediated pathway in 3T3-L1 adipocytes.	Endocrinology 20090401
ARC is a critical cardiomyocyte survival switch in doxorubicin cardiotoxicity.	Journal of molecular medicine (Berlin, Germany) 20090401
Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1.	Cellular signalling 20090401
Low molecular mass polypeptide-2 in human trophoblast: over-expression in hydatidiform moles and possible role in trophoblast cell invasion.	Placenta 20090401
The Mycobacterium tuberculosis phagosome is a HLA-I processing competent organelle.	PLoS pathogens 20090401
A cell cycle timer for asymmetric spindle positioning.	PLoS biology 20090401
Proteasome inhibition induces neurite outgrowth through posttranslational modification of TrkA receptor.	The international journal of biochemistry & cell biology 20090301
Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growth.	Diabetes 20090301
Peptides with dual binding specificity for HLA-A2 and HLA-E are encoded by alternatively spliced isoforms of the antioxidant enzyme peroxiredoxin 5.	International immunology 20090301
TGFbeta prevents proteasomal degradation of the cyclin-dependent kinase inhibitor p27kip1 for cell cycle arrest.	Cell cycle (Georgetown, Tex.) 20090301
Nigral degeneration with inclusion body formation and behavioral changes in rats after proteasomal inhibition.	Stereotactic and functional neurosurgery 20090301
Protective effect against Parkinson's disease-related insults through the activation of XBP1.	Brain research 20090227
Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates.	Molecular cell 20090227
Diastereo- and enantioselective synthesis of beta-hydroxy-alpha-amino acids: application to the synthesis of a key intermediate for lactacystin.	The Journal of organic chemistry 20090220
Inhibition of the 20S proteosome by a protein proteinase inhibitor: evidence that a natural serine proteinase inhibitor can inhibit a threonine proteinase.	Journal of biochemistry 20090201
Proteasome regulation of dynamic transcription factor occupancy on the GnRH-stimulated luteinizing hormone beta-subunit promoter.	Molecular endocrinology (Baltimore, Md.) 20090201
Rift Valley fever virus NSs protein promotes post-transcriptional downregulation of protein kinase PKR and inhibits eIF2alpha phosphorylation.	PLoS pathogens 20090201
Post-translational modification of cyclin A1 is associated with staurosporine and TNFalpha induced apoptosis in leukemic cells.	Molecular and cellular biochemistry 20090101
The host adherens junction molecule nectin-1 is degraded by chlamydial protease-like activity factor (CPAF) in Chlamydia trachomatis-infected genital epithelial cells.	Microbes and infection 20090101
Autophagy contributes to degradation of Hirano bodies.	Autophagy 20090101
Epac mediates PACAP-dependent long-term depression in the hippocampus.	The Journal of physiology 20090101
In vitro activity of bortezomib in cultures of patient tumour cells--potential utility in haematological malignancies.	Medical oncology (Northwood, London, England) 20090101
Antiretroviral-related adipocyte dysfunction and lipodystrophy in HIV-infected patients: Alteration of the PPARγ-dependent pathways.	PPAR research 20090101
Synergistic apoptosis induction in leukemic cells by the phosphatase inhibitor salubrinal and proteasome inhibitors.	PloS one 20090101
Post-translational inhibition of IP-10 secretion in IEC by probiotic bacteria: impact on chronic inflammation.	PloS one 20090101
Post-translational regulation of Oct4 transcriptional activity.	PloS one 20090101
Auto-ubiquitination-induced degradation of MALT1-API2 prevents BCL10 destabilization in t(11;18)(q21;q21)-positive MALT lymphoma.	PloS one 20090101
HIV aspartyl peptidase inhibitors interfere with cellular proliferation, ultrastructure and macrophage infection of Leishmania amazonensis.	PloS one 20090101
The anti-apoptotic activity of BAG3 is restricted by caspases and the proteasome.	PloS one 20090101
Regulation of ErbB2 receptor status by the proteasomal DUB POH1.	PloS one 20090101
Helicobacter pylori induces cancer cell motility independent of the c-Met receptor.	Journal of carcinogenesis 20090101
Proteasome-independent degradation of HIV-1 in naturally non-permissive human placental trophoblast cells.	Retrovirology 20090101
The immunosuppressive properties of the HIV Vpr protein are linked to a single highly conserved residue, R90.	PloS one 20090101
Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP.	PloS one 20090101
Long-term potentiation in isolated dendritic spines.	PloS one 20090101
Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson's disease.	Journal of translational medicine 20090101
Mitogen-activated protein kinases and NFkappaB are involved in SP-A-enhanced responses of macrophages to mycobacteria.	Respiratory research 20090101
Hypoxia-induced transcription of dopamine D3 and D4 receptors in human neuroblastoma and astrocytoma cells.	BMC neuroscience 20090101
The cytotoxicity of gamma-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by gamma-secretase inhibition.	Breast cancer research : BCR 20090101
FoxM1 is a general target for proteasome inhibitors.	PloS one 20090101
50 Hz extremely low frequency electromagnetic fields enhance protein carbonyl groups content in cancer cells: effects on proteasomal systems.	Journal of biomedicine & biotechnology 20090101
Immature and mature species of the human Prostacyclin Receptor are ubiquitinated and targeted to the 26S proteasomal or lysosomal degradation pathways, respectively.	Journal of molecular signaling 20090101
Proteasomal degradation of beta-carotene metabolite--modified proteins.	BioFactors (Oxford, England) 20090101
Investigating bacterial sources of toxicity as an environmental contributor to dopaminergic neurodegeneration.	PloS one 20090101
Notch versus the proteasome: what is the target of gamma-secretase inhibitor-I?	Breast cancer research : BCR 20090101
The C-terminal sequence of RhoB directs protein degradation through an endo-lysosomal pathway.	PloS one 20090101
Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases.	PloS one 20090101
CXCR4 expression heterogeneity in neuroblastoma cells due to ligand-independent regulation.	Molecular cancer 20090101
Discovery of novel proteasome inhibitors using a high-content cell-based screening system.	PloS one 20090101
Ziram causes dopaminergic cell damage by inhibiting E1 ligase of the proteasome.	The Journal of biological chemistry 20081212
ER stress is the initial response to polyglutamine toxicity in PC12 cells.	Biochemical and biophysical research communications 20081212
Structural basis for activation and inhibition of the secreted chlamydia protease CPAF.	Cell host & microbe 20081211
Consequences of the DYT1 mutation on torsinA oligomerization and degradation.	Neuroscience 20081202
Proteasome inhibitor-induced apoptosis is mediated by positive feedback amplification of PKCdelta proteolytic activation and mitochondrial translocation.	Journal of cellular and molecular medicine 20081201
Proteomic analysis of Chlamydia pneumoniae-infected HL cells reveals extensive degradation of cytoskeletal proteins.	FEMS immunology and medical microbiology 20081201
Enhanced killing of androgen-independent prostate cancer cells using inositol hexakisphosphate in combination with proteasome inhibitors.	British journal of cancer 20081104
Induction of BAG2 protein during proteasome inhibitor-induced apoptosis in thyroid carcinoma cells.	British journal of pharmacology 20081101
Study of the effects of proteasome inhibitors on ribosomal protein S19 (RPS19) mutants, identified in patients with Diamond-Blackfan anemia.	Haematologica 20081101
Proteasome-dependent degradation of Chk1 kinase induced by the topoisomerase II inhibitor R16 contributes to its anticancer activity.	Cancer biology & therapy 20081101
Urea-mediated cross-presentation of soluble Epstein-Barr virus BZLF1 protein.	PLoS pathogens 20081101
S-nitrosylation of surfactant protein-D controls inflammatory function.	PLoS biology 20081101
Proteasome affects the expression of aryl hydrocarbon receptor-regulated proteins.	Environmental toxicology and pharmacology 20081101
The ubiquitin-proteasome system is necessary for long-term synaptic depression in Aplysia.	The Journal of neuroscience : the official journal of the Society for Neuroscience 20081008
Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement.	Neurobiology of disease 20081001
The ubiquitin ligase Nedd4 mediates oxidized low-density lipoprotein-induced downregulation of insulin-like growth factor-1 receptor.	American journal of physiology. Heart and circulatory physiology 20081001
c-Jun N-terminal kinase mediates lactacystin-induced dopamine neuron degeneration.	Journal of neuropathology and experimental neurology 20081001
A combination of proteasome inhibitors and antibiotics prevents lethality in a septic shock model.	Innate immunity 20081001
Signal peptide-dependent inhibition of MHC class I heavy chain translation by rhesus cytomegalovirus.	PLoS pathogens 20081001
A new synthetic approach to (+)-lactacystin based on radical cyclisation of enantiopure alpha-ethynyl substituted serine derivatives to 4-methylenepyrrolidinones.	Organic & biomolecular chemistry 20080921
Mitochondria and ubiquitin-proteasomal system interplay: relevance to Parkinson's disease.	Free radical biology & medicine 20080915
Inhibition of proteasome activity blocks Trypanosoma cruzi growth and metacyclogenesis.	Parasitology research 20080901
Insulin potentiates cytokine-induced VCAM-1 expression in human endothelial cells.	Biochimica et biophysica acta 20080901
Regulation of myocardin factor protein stability by the LIM-only protein FHL2.	American journal of physiology. Heart and circulatory physiology 20080901
Nuclear proteasomal degradation and cytoplasmic retention underlie early nuclear exclusion of transcription factor Max upon axon damage.	Experimental neurology 20080901
Kaposi's sarcoma-associated herpesvirus K7 induces viral G protein-coupled receptor degradation and reduces its tumorigenicity.	PLoS pathogens 20080901
Cadmium-induced activation of stress signaling pathways, disruption of ubiquitin-dependent protein degradation and apoptosis in primary rat Sertoli cell-gonocyte cocultures.	Toxicological sciences : an official journal of the Society of Toxicology 20080801
Compounds that increase or mimic cyclic adenosine monophosphate enhance tristetraprolin degradation in lipopolysaccharide-treated murine j774 macrophages.	The Journal of pharmacology and experimental therapeutics 20080801
Angiotensin II type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina.	Diabetes 20080801
The COOH terminus of megalin regulates gene expression in opossum kidney proximal tubule cells.	American journal of physiology. Cell physiology 20080801
Morphine induces ubiquitin-proteasome activity and glutamate transporter degradation.	The Journal of biological chemistry 20080801
Superoxide-mediated proteasomal degradation of Bcl-2 determines cell susceptibility to Cr(VI)-induced apoptosis.	Carcinogenesis 20080801
Pramipexole has astrocyte-mediated neuroprotective effects against lactacystin toxicity.	Neuroscience letters 20080801
Efficient MHC class I presentation by controlled intracellular trafficking of antigens in octaarginine-modified liposomes.	Molecular therapy : the journal of the American Society of Gene Therapy 20080801
Formation of cholesterol-enriched structures by aberrant intracellular accumulation of ATP-binding cassette transporter A1.	Genes to cells : devoted to molecular & cellular mechanisms 20080801
Nurr1 deficiency predisposes to lactacystin-induced dopaminergic neuron injury in vitro and in vivo.	Brain research 20080730
Synthesis and proteasome inhibition of glycyrrhetinic acid derivatives.	Bioorganic & medicinal chemistry 20080715
Ornithine decarboxylase interferes with macrophage-like differentiation and matrix metalloproteinase-9 expression by tumor necrosis factor alpha via NF-kappaB.	Leukemia research 20080701
Dequalinium-induced cell death of yeast expressing alpha-synuclein-GFP fusion protein.	Neurochemical research 20080701
TrkA receptor endolysosomal degradation is both ubiquitin and proteasome dependent.	Traffic (Copenhagen, Denmark) 20080701
Multiple molecular pathways are involved in the neuroprotection of GDNF against proteasome inhibitor induced dopamine neuron degeneration in vivo.	Experimental biology and medicine (Maywood, N.J.) 20080701
Proteasomal degradation of IRS-2, but not IRS-1 by calcineurin inhibition: attenuation of insulin-like growth factor-I-induced GSK-3beta and ERK pathways in adrenal chromaffin cells.	Neuropharmacology 20080701
Proteasome inhibition suppresses essential immune functions of human CD4+ T cells.	Immunology 20080601
The intracellular accumulation of polymeric neuroserpin explains the severity of the dementia FENIB.	Human molecular genetics 20080601
Carbon monoxide decreases the level of iNOS protein and active dimer in IL-1beta-stimulated hepatocytes.	Nitric oxide : biology and chemistry 20080601
Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson's disease.	Journal of neurochemistry 20080601
Rescue of mutant alpha-galactosidase A in the endoplasmic reticulum by 1-deoxygalactonojirimycin leads to trafficking to lysosomes.	Biochimica et biophysica acta 20080601
NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33(ING1b).	EMBO reports 20080601
Comparison of neuroprotective and neurorestorative capabilities of rasagiline and selegiline against lactacystin-induced nigrostriatal dopaminergic degeneration.	Journal of neurochemistry 20080601
Proteasomal abnormalities in cortical Lewy body disease and the impact of proteasomal inhibition within cortical and cholinergic systems.	Journal of neural transmission (Vienna, Austria : 1996) 20080601
Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways.	Cellular signalling 20080601
Zinc adaptation and resistance to cadmium toxicity in mammalian cells: molecular insight by proteomic analysis.	Proteomics 20080601
Natural compounds with proteasome inhibitory activity for cancer prevention and treatment.	Current protein & peptide science 20080601
A green tea component suppresses posttranslational expression of basic fibroblast growth factor in colorectal cancer.	Gastroenterology 20080601
Protein degradation, as with protein synthesis, is required during not only long-term spatial memory consolidation but also reconsolidation.	The European journal of neuroscience 20080601
Water and ion channels: crucial in the initiation and progression of apoptosis in central nervous system?	Current neuropharmacology 20080601
Regulation of Akt mRNA and protein levels by glycogen synthase kinase-3beta in adrenal chromaffin cells: effects of LiCl and SB216763.	European journal of pharmacology 20080531
Proteasomes cleave at multiple sites within polyglutamine tracts: activation by PA28gamma(K188E).	The Journal of biological chemistry 20080509
Promotion of neurite outgrowth by fibroblast growth factor receptor 1 overexpression and lysosomal inhibition of receptor degradation in pheochromocytoma cells and adult sensory neurons.	Neuroscience 20080502
Proteasome inhibitors remarkably prevent translesion replication in cancer cells but not normal cells.	Cancer science 20080501
Inhibition of plasminogen activator inhibitor-1 expression in vascular smooth muscle cells by protoporphyrins through a heme oxygenase-independent mechanism.	Molecular and cellular biochemistry 20080501
Simultaneous presentation and cross-presentation of immune-stimulating complex-associated cognate antigen by antigen-specific B cells.	European journal of immunology 20080501
Practical synthesis of a key intermediate for lactacystin from (R)-4-hydroxymethyl-2-phenyl-4,5-dihydrooxazol-4-ylmethyl acetate.	Chemical & pharmaceutical bulletin 20080501
Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction.	PLoS pathogens 20080501
Human immunodeficiency virus type 1 gp120-mediated disruption of tight junction proteins by induction of proteasome-mediated degradation of zonula occludens-1 and -2 in human brain microvascular endothelial cells.	Journal of neurovirology 20080501
Caffeine induces cell death via activation of apoptotic signal and inactivation of survival signal in human osteoblasts.	International journal of molecular sciences 20080501
BV-2 stimulation by lactacystin results in a strong inflammatory reaction and apoptotic neuronal death in SH-SY5Y cells.	Brain research 20080418
Agonist-specific down regulation of mu-opioid receptors: Different cellular pathways are activated by different opioid agonists.	Life sciences 20080409
Steroidogenic activity of StAR requires contact with mitochondrial VDAC1 and phosphate carrier protein.	The Journal of biological chemistry 20080404
Enantioselective total syntheses of omuralide, 7-epi-omuralide, and (+)-lactacystin.	The Journal of organic chemistry 20080321
Unsaturated lipid peroxidation-derived aldehydes activate autophagy in vascular smooth-muscle cells.	The Biochemical journal 20080315
Prevention of deoxycholate-induced gastric apoptosis by aspirin: roles of NF-kappaB and PKC signaling.	The Journal of surgical research 20080301
Arkadia regulates TGF-beta signaling during renal tubular epithelial to mesenchymal cell transition.	Kidney international 20080301
Proteasome inhibition: an early or late event in nitric oxide-induced neuronal death?	Nitric oxide : biology and chemistry 20080301
Effect of an experimental proteasome inhibitor on the cytoskeleton, cytosolic protein turnover, and induction in the neuronal cells in vitro.	Neurotoxicology 20080301
Mitogen-activated protein kinase kinase 4/c-Jun NH2-terminal kinase kinase 1 protein expression is subject to translational regulation in prostate cancer cell lines.	Molecular cancer research : MCR 20080301
A 39 kDa fragment of endogenous ASK1 suggests specific cleavage not degradation by the proteasome.	IUBMB life 20080301
Yessotoxin inhibits the complete degradation of E-cadherin.	Toxicology 20080227
Proteasomal inhibition and apoptosis regulatory changes in human isolated lymphocytes: the synergistic role of dopamine.	Journal of cellular biochemistry 20080215
Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response.	Aging cell 20080201
Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway.	Traffic (Copenhagen, Denmark) 20080201
Immunocytochemical analysis for intracellular dynamics of C1GalT associated with molecular chaperone, Cosmc.	Biochemical and biophysical research communications 20080201
Protein quality control: the who's who, the where's and therapeutic escapes.	Histochemistry and cell biology 20080201
Cyclic AMP-dependent proteolysis of GATA-6 expressed on the intracellular membrane.	Cell biology international 20080201
Oxidative injury induces selective rather than global inhibition of proteasomal activity.	Journal of molecular and cellular cardiology 20080201
LPS induces the TNF-alpha-mediated downregulation of rat liver aquaporin-8: role in sepsis-associated cholestasis.	American journal of physiology. Gastrointestinal and liver physiology 20080201
Sensitivity of tumor cells to proteasome inhibitors is associated with expression levels and composition of proteasome subunits.	Cancer 20080201
Efficient total synthesis of novel bioactive microbial metabolites.	Accounts of chemical research 20080201
Nitric oxide-dependent proteasomal degradation of cytochrome P450 2B proteins.	The Journal of biological chemistry 20080111
Hsp90-mediated cytosolic refolding of exogenous proteins internalized by dendritic cells.	The EMBO journal 20080109
Neonatal and adult microglia cross-present exogenous antigens.	Glia 20080101
Constitutive activation of c-Met is correlated with c-Met overexpression and dependent on cell-matrix adhesion in lung adenocarcinoma cell lines.	Cancer science 20080101
Oncostatin M induces growth arrest of skeletal muscle cells in G1 phase by regulating cyclin D1 protein level.	Cellular signalling 20080101
Cross-presentation of NY-ESO-1 cytotoxic T lymphocyte epitope fused to human heat shock cognate protein 70 by dendritic cells.	Cancer science 20080101
Metabolic and morphological alterations induced by proteolysis-inducing factor from Walker tumour-bearing rats in C2C12 myotubes.	BMC cancer 20080101
Hsc70 focus formation at the periphery of HSV-1 transcription sites requires ICP27.	PloS one 20080101
Alterations in the Notch4 pathway in cerebral endothelial cells by the HIV aspartyl protease inhibitor, nelfinavir.	BMC neuroscience 20080101
Expression of K6W-ubiquitin in lens epithelial cells leads to upregulation of a broad spectrum of molecular chaperones.	Molecular vision 20080101
Excessive islet NO generation in type 2 diabetic GK rats coincides with abnormal hormone secretion and is counteracted by GLP-1.	PloS one 20080101
Marine actinomycetes: a new source of compounds against the human malaria parasite.	PloS one 20080101
Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumour activity in neuroblastoma cells.	Molecular cancer 20080101
Ubiquitination is required for effective replication of coxsackievirus B3.	PloS one 20080101
AIP4/Itch regulates Notch receptor degradation in the absence of ligand.	PloS one 20080101
Supernatant from bifidobacterium differentially modulates transduction signaling pathways for biological functions of human dendritic cells.	PloS one 20080101
Comprehensive study of proteasome inhibitors against Plasmodium falciparum laboratory strains and field isolates from Gabon.	Malaria journal 20080101
Changes in ocular aquaporin-4 (AQP4) expression following retinal injury.	Molecular vision 20080101
Bifidobacterium strains suppress in vitro the pro-inflammatory milieu triggered by the large intestinal microbiota of coeliac patients.	Journal of inflammation (London, England) 20080101
Targeting the UPS as therapy in multiple myeloma.	BMC biochemistry 20080101
The UPS: a promising target for breast cancer treatment.	BMC biochemistry 20080101
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity.	Molecular brain 20080101
Modulation of the NF-kappaB pathway by Bordetella pertussis filamentous hemagglutinin.	PloS one 20080101
Differential role of beta-arrestin ubiquitination in agonist-promoted down-regulation of M1 vs M2 muscarinic acetylcholine receptors.	Journal of molecular signaling 20080101
Reduction of infectious bursal disease virus replication in cultured cells by proteasome inhibitors.	Virus genes 20071201

Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor.

The Biochemical journal 20140215

Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells.

PloS one 20140101

Forskolin stimulation promotes urea transporter UT-A1 ubiquitination, endocytosis, and degradation in MDCK cells.

American journal of physiology. Renal physiology 20121101

Δ⁹-tetrahydrocannabinol (Δ⁹-THC) exerts a direct neuroprotective effect in a human cell culture model of Parkinson's disease.

Neuropathology and applied neurobiology 20121001

Chaperones, but not oxidized proteins, are ubiquitinated after oxidative stress.

Free radical biology & medicine 20121001

Proteasome inhibition decreases inflammation in human endothelial cells exposed to lipopolysaccharide.

Journal of cardiovascular pharmacology 20121001

[Enhanced activation of T lymphocytes by urease-deficient recombinant bacillus Calmette-Guérin producing heat shock protein 70-major membrane protein-II fusion protein].

Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association 20120901

Expression of the ubiquitin proteasome system in neonatal rat gonocytes and spermatogonia: role in gonocyte differentiation.

Biology of reproduction 20120801

Laminin-111 stimulates proliferation of mouse embryonic stem cells through a reduction of gap junctional intercellular communication via RhoA-mediated Cx43 phosphorylation and dissociation of Cx43/ZO-1/drebrin complex.

Stem cells and development 20120720

Ubiquitin-proteasome system inhibitors and AMPK regulation in hepatic cold ischaemia and reperfusion injury: possible mechanisms.

Clinical science (London, England : 1979) 20120701

Lys(203) and Lys(382) are essential for the proteasomal degradation of BACE1.

Current Alzheimer research 20120601

Differential degradation of full-length and cleaved ataxin-7 fragments in a novel stable inducible SCA7 model.

Journal of molecular neuroscience : MN 20120601

Increased expression of α-synuclein by SNCA duplication is associated with resistance to toxic stimuli.

Journal of molecular neuroscience : MN 20120601

Diltiazem enhances the apoptotic effects of proteasome inhibitors to induce prostate cancer cell death.

The Journal of pharmacology and experimental therapeutics 20120601

The effect of the NF-kappa B inhibitors curcumin and lactacystin on myogenic differentiation of rhabdomyosarcoma cells.

Differentiation; research in biological diversity 20120601

The regulation of N-terminal Huntingtin (Htt552) accumulation by Beclin1.

Acta pharmacologica Sinica 20120601

Diphenylarsinic acid promotes degradation of glutaminase C by mitochondrial Lon protease.

The Journal of biological chemistry 20120525

Human tau may modify glucocorticoids-mediated regulation of cAMP-dependent kinase and phosphorylated cAMP response element binding protein.

Neurochemical research 20120501

P53 and the proteasome regulate androgen receptor activity.

Cancer biology & therapy 20120501

High sensitivity of embryonic stem cells to proteasome inhibitors correlates with low expression of heat shock protein and decrease of pluripotent cell marker expression.

BMB reports 20120501

Design and synthesis of naphthoquinone derivatives as antiproliferative agents and 20S proteasome inhibitors.

Bioorganic & medicinal chemistry letters 20120415

The plasma membrane redox enzyme NQO1 sustains cellular energetics and protects human neuroblastoma cells against metabolic and proteotoxic stress.

Age (Dordrecht, Netherlands) 20120401

Effects of phosphatase and proteasome inhibitors on Borealin phosphorylation and degradation.

Journal of biochemistry 20120401

A critical role for the inducible proteasomal subunits LMP7 and MECL1 in cytokine production by activated murine splenocytes.

Pharmacology 20120401

Proteasomal inhibition restores biological function of mis-sense mutated dysferlin in patient-derived muscle cells.

The Journal of biological chemistry 20120323

Met kinase-dependent loss of the E3 ligase Cbl in gastric cancer.

The Journal of biological chemistry 20120309

TWEAK causes myotube atrophy through coordinated activation of ubiquitin-proteasome system, autophagy, and caspases.

Journal of cellular physiology 20120301

Modeling mitochondrial dysfunctions in the brain: from mice to men.

Journal of inherited metabolic disease 20120301

Identification of HSP90 as a new GABARAPL1 (GEC1)-interacting protein.

Biochimie 20120301

Presenilin-2 regulates the degradation of RBP-Jk protein through p38 mitogen-activated protein kinase.

Journal of cell science 20120301

An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid.

Nature communications 20120221

Peroxisome proliferator-activated receptor-γ activation reduces cyclooxygenase-2 expression in vascular smooth muscle cells from hypertensive rats by interfering with oxidative stress.

Journal of hypertension 20120201

Viral mediated redirection of NEMO/IKKγ to autophagosomes curtails the inflammatory cascade.

PLoS pathogens 20120201

p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells.

PLoS biology 20120201

The peptidases of Trypanosoma cruzi: digestive enzymes, virulence factors, and mediators of autophagy and programmed cell death.

Biochimica et biophysica acta 20120101

Janus kinase 2--a novel negative regulator of estrogen receptor α function.

Cellular signalling 20120101

Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1.

The Biochemical journal 20120101

gp130 cytokines stimulate proteasomal degradation of tyrosine hydroxylase via extracellular signal regulated kinases 1 and 2.

Journal of neurochemistry 20120101

Chromatin remodelling protein SMAR1 inhibits p53 dependent transactivation by regulating acetyl transferase p300.

The international journal of biochemistry & cell biology 20120101

Effects of proteasome inhibitors on the nucleolar size of porcine oocytes.

The Journal of reproduction and development 20120101

Functional processing of nuclear Ca2+/calmodulin-dependent protein kinase phosphatase (CaMKP-N): evidence for a critical role of proteolytic processing in the regulation of its catalytic activity, subcellular localization and substrate targeting in vivo.

Archives of biochemistry and biophysics 20120101

M30, a brain permeable multitarget neurorestorative drug in post nigrostriatal dopamine neuron lesion of parkinsonism animal models.

Parkinsonism & related disorders 20120101

Trafficking-deficient G572R-hERG and E637K-hERG activate stress and clearance pathways in endoplasmic reticulum.

PloS one 20120101

Human papillomavirus 18 E6 inhibits phosphorylation of p53 expressed in HeLa cells.

Cell & bioscience 20120101

Imbalance of neurotrophin receptor isoforms TrkB-FL/TrkB-T1 induces neuronal death in excitotoxicity.

Cell death & disease 20120101

Translation of MMTV Gag requires nuclear events involving splicing motifs in addition to the viral Rem protein and RmRE.

Retrovirology 20120101

Mammalian ste20-like kinase and SAV1 promote 3T3-L1 adipocyte differentiation by activation of PPARγ.

PloS one 20120101

Protein carbonylation and aggregation precede neuronal apoptosis induced by partial glutathione depletion.

ASN neuro 20120101

Internalization and down-regulation of the ALK receptor in neuroblastoma cell lines upon monoclonal antibodies treatment.

PloS one 20120101

Role of the cellular prion protein in oligodendrocyte precursor cell proliferation and differentiation in the developing and adult mouse CNS.

PloS one 20120101

Differential regulation of cutaneous oncoprotein HPVE6 by wtp53, mutant p53R248W and ΔNp63α is HPV type dependent.

PloS one 20120101

Parkinson's disease DJ-1 L166P alters rRNA biogenesis by exclusion of TTRAP from the nucleolus and sequestration into cytoplasmic aggregates via TRAF6.

PloS one 20120101

Engagement of ubiquitination and de-ubiquitination at rostral ventrolateral medulla in experimental brain death.

Journal of biomedical science 20120101

Lipopolysaccharide-induced neuroinflammation leads to the accumulation of ubiquitinated proteins and increases susceptibility to neurodegeneration induced by proteasome inhibition in rat hippocampus.

Journal of neuroinflammation 20120101

Escape from the Phagosome: The Explanation for MHC-I Processing of Mycobacterial Antigens?

Frontiers in immunology 20120101

Cross-presentation of cell-associated antigens by mouse splenic dendritic cell populations.

Frontiers in immunology 20120101

Nicotinic acetylcholine receptor agonists attenuate septic acute kidney injury in mice by suppressing inflammation and proteasome activity.

PloS one 20120101

Phosphorylation of nicastrin by SGK1 leads to its degradation through lysosomal and proteasomal pathways.

PloS one 20120101

MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I interferon production after activation of the antiviral RIG-I-like receptors.

BMC biology 20120101

Fibroblast growth factor signaling potentiates VE-cadherin stability at adherens junctions by regulating SHP2.

PloS one 20120101

Novel strategies for immunotherapy in multiple myeloma: previous experience and future directions.

Clinical & developmental immunology 20120101

AMPA receptor trafficking in homeostatic synaptic plasticity: functional molecules and signaling cascades.

Neural plasticity 20120101

Estrogen and progesterone regulate p27kip1 levels via the ubiquitin-proteasome system: pathogenic and therapeutic implications for endometrial cancer.

PloS one 20120101

Release of Full-Length PrP(C) from Cultured Neurons Following Neurotoxic Challenges.

Frontiers in neurology 20120101

γ-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1.

The Journal of biological chemistry 20111209

p53-Independent up-regulation of a TRAIL receptor DR5 by proteasome inhibitors: a mechanism for proteasome inhibitor-enhanced TRAIL-induced apoptosis.

Biochemical and biophysical research communications 20111209

Proteasome inhibitors induce apoptosis and reduce viral replication in primary effusion lymphoma cells.

Biochemical and biophysical research communications 20111202

Neuroprotective effects of MAPK/ERK1/2 and calpain inhibitors on lactacystin-induced cell damage in primary cortical neurons.

Neurotoxicology 20111201

Proteasome inhibitor lactacystin augments natural killer cell cytotoxicity of myeloma via downregulation of HLA class I.

Biochemical and biophysical research communications 20111111

TRAIL promotes caspase-dependent pro-inflammatory responses via PKCδ activation by vascular smooth muscle cells.

Cell death & disease 20111101

Stereospecific total syntheses of proteasome inhibitors omuralide and lactacystin.

The Journal of organic chemistry 20111021

P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium/calpain-dependent mechanism.

Oncogene 20111013

Protection of neuronal calcium sensor 1 protein in cells treated with paclitaxel.

The Journal of biological chemistry 20111007

Nrf2/HO-1 pathway activation by manganese is associated with reactive oxygen species and ubiquitin-proteasome pathway, not MAPKs signaling.

Journal of applied toxicology : JAT 20111001

Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease.

British journal of pharmacology 20111001

New betulinic acid derivatives as potent proteasome inhibitors.

Bioorganic & medicinal chemistry letters 20111001

Chlamydia trachomatis co-opts the FGF2 signaling pathway to enhance infection.

PLoS pathogens 20111001

RB1CC1 protein positively regulates transforming growth factor-beta signaling through the modulation of Arkadia E3 ubiquitin ligase activity.

The Journal of biological chemistry 20110916

The human papillomavirus E6 oncogene represses a cell adhesion pathway and disrupts focal adhesion through degradation of TAp63β upon transformation.

PLoS pathogens 20110901

Targeting of a chlamydial protease impedes intracellular bacterial growth.

PLoS pathogens 20110901

Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta.

The Journal of biological chemistry 20110819

[Expression and regulation of androgen receptor in the androgen-independent conversion of prostate cancer cells].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20110818

Crosstalk between Nodal/activin and MAPK p38 signaling is essential for anterior-posterior axis specification.

Current biology : CB 20110809

Changes in iron-regulatory gene expression occur in human cell culture models of Parkinson's disease.

Neurochemistry international 20110801

Leishmania donovani: proteasome-mediated down-regulation of methionine adenosyltransferase.

Parasitology 20110801

The Parkinson's disease protein LRRK2 impairs proteasome substrate clearance without affecting proteasome catalytic activity.

Cell death & disease 20110801

Beta-HPV 5 and 8 E6 promote p300 degradation by blocking AKT/p300 association.

PLoS pathogens 20110801

γ-Hydroxy-1,N2-propano-2'-deoxyguanosine DNA adduct conjugates the N-terminal amine of the KWKK peptide via a carbinolamine linkage.

Chemical research in toxicology 20110718

Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies.

Cell biochemistry and biophysics 20110701

Proteasomal degradation of myocardin is required for its transcriptional activity in vascular smooth muscle cells.

Journal of cellular physiology 20110701

[Content of chaperon Hsp70 in dopaminergic neurons of the black substance increases in proteasome dysfunstion].

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20110701

Valosin-containing protein gene mutations: cellular phenotypes relevant to neurodegeneration.

Journal of molecular neuroscience : MN 20110601

PDGF-induced vascular smooth muscle cell proliferation is associated with dysregulation of insulin receptor substrates.

American journal of physiology. Cell physiology 20110601

LPS-induced formation of immunoproteasomes: TNF-α and nitric oxide production are regulated by altered composition of proteasome-active sites.

Cell biochemistry and biophysics 20110601

Identification of DNA-damage DNA-binding protein 1 as a conditional essential factor for cytomegalovirus replication in interferon-γ-stimulated cells.

PLoS pathogens 20110601

Mitogen-activated protein kinase kinase 1 (MEK1) stabilizes MyoD through direct phosphorylation at tyrosine 156 during myogenic differentiation.

The Journal of biological chemistry 20110527

The role of the proteasome in the generation of MHC class I ligands and immune responses.

Cellular and molecular life sciences : CMLS 20110501

Functional 20S proteasomes in mature human red blood cells.

Experimental biology and medicine (Maywood, N.J.) 20110501

[Effect of epigallocatechin gallate on lactacystin-induced PC12 cell injury].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20110501

Disassembly of the JIP1/JNK molecular scaffold by caspase-3-mediated cleavage of JIP1 during apoptosis.

Experimental cell research 20110415

Semi-high throughput method of measuring proteasome inhibition in vitro and in cultured cells.

Cell biology and toxicology 20110401

Lactacystin, a proteasome inhibitor, enhances BMP-induced osteoblastic differentiation by increasing active Smads.

Biochemical and biophysical research communications 20110401

Synthesis and proteasome inhibition of lithocholic acid derivatives.

Bioorganic & medicinal chemistry letters 20110401

Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling.

Cell 20110401

The neuroprotective effect of modified Yeoldahanso-tang via autophagy enhancement in models of Parkinson's disease.

Journal of ethnopharmacology 20110324

Beta-subunits promote the expression of Ca(V)2.2 channels by reducing their proteasomal degradation.

The Journal of biological chemistry 20110318

Opioid-induced down-regulation of RGS4: role of ubiquitination and implications for receptor cross-talk.

The Journal of biological chemistry 20110311

Does 1-(R)-aminoindan possess neuroprotective properties against experimental Parkinson's disease?

Antioxidants & redox signaling 20110301

Long-term aversive taste memory requires insular and amygdala protein degradation.

Neurobiology of learning and memory 20110301

Individual caspase-10 isoforms play distinct and opposing roles in the initiation of death receptor-mediated tumour cell apoptosis.

Cell death & disease 20110301

A Pseudomonas aeruginosa toxin that hijacks the host ubiquitin proteolytic system.

PLoS pathogens 20110301

The role of monoubiquitination in endocytic degradation of human ether-a-go-go-related gene (hERG) channels under low K+ conditions.

The Journal of biological chemistry 20110225

Transcription factor IIS cooperates with the E3 ligase UBR5 to ubiquitinate the CDK9 subunit of the positive transcription elongation factor B.

The Journal of biological chemistry 20110218

Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability.

Oncogene 20110217

Processing of optineurin in neuronal cells.

The Journal of biological chemistry 20110204

Up-regulation of endoplasmic reticulum stress-related genes during the early phase of treatment of cultured cortical neurons by the proteasomal inhibitor lactacystin.

Journal of cellular physiology 20110201

Pathogenic VCP/TER94 alleles are dominant actives and contribute to neurodegeneration by altering cellular ATP level in a Drosophila IBMPFD model.

PLoS genetics 20110201

What has the study of the K3 and K5 viral ubiquitin E3 ligases taught us about ubiquitin-mediated receptor regulation?

Viruses 20110201

Tripeptidyl peptidase II serves as an alternative to impaired proteasome to maintain viral growth in the host cells.

FEBS letters 20110103

Glucocorticoid-induced activation of caspase-8 protects the glucocorticoid-induced protein Gilz from proteasomal degradation and induces its binding to SUMO-1 in murine thymocytes.

Cell death and differentiation 20110101

Wnt3a regulates tumor necrosis factor-α-stimulated interleukin-6 release in osteoblasts.

Molecular and cellular endocrinology 20110101

Environmental exposure, obesity, and Parkinson's disease: lessons from fat and old worms.

Environmental health perspectives 20110101

Toll-like receptor 4 mediates lipopolysaccharide-induced muscle catabolism via coordinate activation of ubiquitin-proteasome and autophagy-lysosome pathways.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110101

Inhibition of all-trans-retinoic acid-induced proteasome activation potentiates the differentiating effect of retinoid in acute myeloid leukemia cells.

Molecular carcinogenesis 20110101

β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency.

Diabetes 20110101

Regulation of posttranscriptional modification as a possible therapeutic approach for retinal neuroprotection.

Journal of ophthalmology 20110101

Effects of proteasome inhibitors on rat renal fibrosis in vitro and in vivo.

Nephrology (Carlton, Vic.) 20110101

Steroids up-regulate p66Shc longevity protein in growth regulation by inhibiting its ubiquitination.

PloS one 20110101

Perturbation with intrabodies reveals that calpain cleavage is required for degradation of huntingtin exon 1.

PloS one 20110101

The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease.

International journal of molecular sciences 20110101

Senescence marker protein 30 (SMP30) expression in eukaryotic cells: existence of multiple species and membrane localization.

PloS one 20110101

Evolution of extra-nigral damage predicts behavioural deficits in a rat proteasome inhibitor model of Parkinson's disease.

PloS one 20110101

Thiazole antibiotic thiostrepton synergize with bortezomib to induce apoptosis in cancer cells.

PloS one 20110101

Resveratrol protects leukemic cells against cytotoxicity induced by proteasome inhibitors via induction of FOXO1 and p27Kip1.

BMC cancer 20110101

Trafficking defect and proteasomal degradation contribute to the phenotype of a novel KCNH2 long QT syndrome mutation.

PloS one 20110101

A novel signaling pathway mediated by the nuclear targeting of C-terminal fragments of mammalian Patched 1.

PloS one 20110101

Photodynamic treatment induces an apoptotic pathway involving calcium, nitric oxide, p53, p21-activated kinase 2, and c-Jun N-terminal kinase and inactivates survival signal in human umbilical vein endothelial cells.

International journal of molecular sciences 20110101

Inverse baseline expression pattern of the NEP/neuropeptides and NFκB/proteasome pathways in androgen-dependent and androgen-independent prostate cancer cells.

Cancer cell international 20110101

HGF/c-met/Stat3 signaling during skin tumor cell invasion: indications for a positive feedback loop.

BMC cancer 20110101

Firefly luciferase and RLuc8 exhibit differential sensitivity to oxidative stress in apoptotic cells.

PloS one 20110101

C-terminus glycans with critical functional role in the maturation of secretory glycoproteins.

PloS one 20110101

Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neurons.

Molecular neurodegeneration 20110101

Parkin, A Top Level Manager in the Cell's Sanitation Department.

The open biochemistry journal 20110101

p21(WAF1/CIP1) upregulation through the stress granule-associated protein CUGBP1 confers resistance to bortezomib-mediated apoptosis.

PloS one 20110101

Negative regulation of interferon-β gene expression during acute and persistent virus infections.

PloS one 20110101

NOTCH-1 and NOTCH-4 are novel gene targets of PEA3 in breast cancer: novel therapeutic implications.

Breast cancer research : BCR 20110101

Analysis of proteasomal proteolysis during the in vitro metacyclogenesis of Trypanosoma cruzi.

PloS one 20110101

The p53 tumor suppressor is stabilized by inhibitor of growth 1 (ING1) by blocking polyubiquitination.

PloS one 20110101

The monoclonal antibody Zt/f2 targeting RON receptor tyrosine kinase as potential therapeutics against tumor growth-mediated by colon cancer cells.

Molecular cancer 20110101

Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways.

PloS one 20110101

Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons.

PloS one 20110101

CDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton.

PloS one 20110101

Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors.

BMC cancer 20110101

Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4.

Molecular cancer 20110101

Protein C mutation (A267T) results in ER retention and unfolded protein response activation.

PloS one 20110101

SVIP induces localization of p97/VCP to the plasma and lysosomal membranes and regulates autophagy.

PloS one 20110101

In vivo RNAi screen reveals neddylation genes as novel regulators of Hedgehog signaling.

PloS one 20110101

Human metapneumovirus inhibits IFN-β signaling by downregulating Jak1 and Tyk2 cellular levels.

PloS one 20110101

The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation.

Molecular systems biology 20110101

A ubiquitin independent degradation pathway utilized by a hepatitis B virus envelope protein to limit antigen presentation.

PloS one 20110101

Suppression of nitric oxide induction and pro-inflammatory cytokines by novel proteasome inhibitors in various experimental models.

Lipids in health and disease 20110101

The docking protein p130Cas regulates cell sensitivity to proteasome inhibition.

BMC biology 20110101

Hakai reduces cell-substratum adhesion and increases epithelial cell invasion.

BMC cancer 20110101

Substrate-favored lysosomal and proteasomal pathways participate in the normal balance control of insulin precursor maturation and disposal in β-cells.

PloS one 20110101

A double-edged sword role for ubiquitin-proteasome system in brain stem cardiovascular regulation during experimental brain death.

PloS one 20110101

Amorphous silica nanoparticles trigger nitric oxide/peroxynitrite imbalance in human endothelial cells: inflammatory and cytotoxic effects.

International journal of nanomedicine 20110101

Postnatal proteasome inhibition induces neurodegeneration and cognitive deficiencies in adult mice: a new model of neurodevelopment syndrome.

PloS one 20110101

Inhibition of nitric oxide in LPS-stimulated macrophages of young and senescent mice by δ-tocotrienol and quercetin.

Lipids in health and disease 20110101

Adriamycin enhances proteasome-mediated generation of the proapoptotic processed form of MAGE-A4 in hepatoma cells.

Oncology 20110101

The Nrf1 CNC-bZIP protein is regulated by the proteasome and activated by hypoxia.

PloS one 20110101

The promigratory activity of the matricellular protein galectin-3 depends on the activation of PI-3 kinase.

PloS one 20110101

Phosphorylated alpha-synuclein at Ser-129 is targeted to the proteasome pathway in a ubiquitin-independent manner.

The Journal of biological chemistry 20101224

Cell cycle events mediate lactacystin-induced apoptotic death of neuronal PC12 cells.

Cell biology international 20101201

Manganese-induced downregulation of astroglial glutamine transporter SNAT3 involves ubiquitin-mediated proteolytic system.

Glia 20101201

Identification of p10 as a neurotoxic product generated from the proteolytic cleavage of the neuronal Cdk5 activator.

Journal of cellular biochemistry 20101201

Metabolism and action of proteasome inhibitors in primary human hepatocytes.

Drug metabolism and disposition: the biological fate of chemicals 20101201

NleC, a type III secretion protease, compromises NF-κB activation by targeting p65/RelA.

PLoS pathogens 20101201

Phospho-ΔNp63α/Rpn13-dependent regulation of LKB1 degradation modulates autophagy in cancer cells.

Aging 20101201

Ammonium chloride and tunicamycin are novel toxins for dopaminergic neurons and induce Parkinson's disease-like phenotypes in medaka fish.

Journal of neurochemistry 20101201

TGF-β induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to generation of amyloid β plaques in Alzheimer's disease.

Cell death & disease 20101201

[Sleep changes during degeneration of neurons in the substantia nigra induced by inhibitor of proteasomes lactacystin in rats].

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20101201

Selective susceptibility of human dopaminergic neural stem cells to dopamine-induced apoptosis.

Experimental neurobiology 20101201

Identification of a lysosomal pathway regulating degradation of the bone morphogenetic protein receptor type II.

The Journal of biological chemistry 20101126

Annexin A3 is associated with cell death in lactacystin-mediated neuronal injury.

Neuroscience letters 20101119

Enhanced activation of T lymphocytes by urease-deficient recombinant bacillus Calmette-Guérin producing heat shock protein 70-major membrane protein-II fusion protein.

Journal of immunology (Baltimore, Md. : 1950) 20101115

Fatty acids regulate CREBh via transcriptional mechanisms that are dependent on proteasome activity and insulin.

Molecular and cellular biochemistry 20101101

HTLV-1 evades type I interferon antiviral signaling by inducing the suppressor of cytokine signaling 1 (SOCS1).

PLoS pathogens 20101101

Synthesis of α-amino acids based on chiral tricycloiminolactone derived from natural (+)-camphor.

Accounts of chemical research 20101019

The proteasome regulates bacterial CpG DNA-induced signaling pathways in murine macrophages.

Shock (Augusta, Ga.) 20101001

Expression of alternatively spliced CD45 isoforms by channel catfish clonal T and B cells is dependent on activation state of the cell and regulated by protein synthesis and degradation.

Developmental and comparative immunology 20101001

Neuroprotection of pramipexole in UPS impairment induced animal model of Parkinson's disease.

Neurochemical research 20101001

Proteasome inhibition in medaka brain induces the features of Parkinson's disease.

Journal of neurochemistry 20101001

Proteasome inhibition modeling nigral neuron degeneration in Parkinson's disease.

Journal of neurochemistry 20101001

Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S beta5-subunit.

The Biochemical journal 20100915

ARRDC3 suppresses breast cancer progression by negatively regulating integrin beta4.

Oncogene 20100909

p53 Plays an important role in cell fate determination after exposure to microcystin-LR.

Environmental health perspectives 20100901

Cbl-b enhances Runx2 protein stability and augments osteocalcin promoter activity in osteoblastic cell lines.

Journal of cellular physiology 20100901

Effect of nuclear factor kappa B inhibition on L-NAME-induced hypertension and cardiovascular remodelling.

Journal of hypertension 20100901

Low levels of mutant ubiquitin are degraded by the proteasome in vivo.

Journal of neuroscience research 20100815

Novel D3 dopamine receptor-preferring agonist D-264: Evidence of neuroprotective property in Parkinson's disease animal models induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and lactacystin.

Journal of neuroscience research 20100815

Anthrax lethal toxin activates the inflammasome in sensitive rat macrophages.

Biochemical and biophysical research communications 20100806

Proapoptotic fibronectin fragment induces the degradation of ubiquitinated p53 via proteasomes in periodontal ligament cells.

Journal of periodontal research 20100801

Estrogen receptor beta signaling through phosphatase and tensin homolog/phosphoinositide 3-kinase/Akt/glycogen synthase kinase 3 down-regulates blood-brain barrier breast cancer resistance protein.

The Journal of pharmacology and experimental therapeutics 20100801

The forced aggresome formation of a bovine anion exchanger 1 (AE1) mutant through association with δF508-cystic fibrosis transmembrane conductance regulator upon proteasome inhibition in HEK293 cells.

The Japanese journal of veterinary research 20100801

Minor groove orientation of the KWKK peptide tethered via the N-terminal amine to the acrolein-derived 1,N2-gamma-hydroxypropanodeoxyguanosine lesion with a trimethylene linkage.

Biochemistry 20100727

Regulation of aurora B kinase by the lipid raft protein flotillin-1.

The Journal of biological chemistry 20100702

Determinants of CREB degradation and KChIP2 gene transcription in cardiac memory.

Heart rhythm 20100701

Hypoxic ischemia and proteasome dysfunction alter tau isoform ratio by inhibiting exon 10 splicing.

Journal of neurochemistry 20100701

Effects of Arkadia on airway remodeling through enhancing TGF-beta signaling in allergic rats.

Laboratory investigation; a journal of technical methods and pathology 20100701

Increased degradation of MYPT1 contributes to the development of tolerance to nitric oxide in porcine pulmonary artery.

American journal of physiology. Lung cellular and molecular physiology 20100701

Differential effects of lactacystin on cytokine production in activated Jurkat cells and murine splenocytes.

Cytokine 20100701

Myocardial ischemic preconditioning preserves postischemic function of the 26S proteasome through diminished oxidative damage to 19S regulatory particle subunits.

Circulation research 20100625

Ongoing DNA synthesis in the rat cerebral cortex is regulated by a proteolytic pathway independent of the proteasome and calpains.

Investigational new drugs 20100601

Detrimental effect of the proteasome inhibitor, bortezomib in bacterial superantigen- and lipopolysaccharide-induced systemic inflammation.

Molecular therapy : the journal of the American Society of Gene Therapy 20100601

The 20S proteasome splicing activity discovered by SpliceMet.

PLoS computational biology 20100601

Why do we need multifunctional neuroprotective and neurorestorative drugs for Parkinson's and Alzheimer's diseases as disease modifying agents.

Experimental neurobiology 20100601

The role of local protein synthesis and degradation in axon regeneration.

Experimental neurology 20100501

Proteasome inhibition induces hsp30 and hsp70 gene expression as well as the acquisition of thermotolerance in Xenopus laevis A6 cells.

Cell stress & chaperones 20100501

Ubiquitin/proteasome-dependent down-regulation following clathrin-mediated internalization of histamine H1-receptors in Chinese hamster ovary cells.

Journal of neurochemistry 20100501

Synergistic effect between proteasome and autophagosome in the clearance of polyubiquitinated TDP-43.

Journal of neuroscience research 20100301

Intrastriatal transplantation of GDNF-engineered BMSCs and its neuroprotection in lactacystin-induced Parkinsonian rat model.

Neurochemical research 20100301

The pattern of neuronal loss and survival may reflect differential expression of proteasome activators in Parkinson's disease.

Synapse (New York, N.Y.) 20100301

High glucose and interleukin-1beta downregulate interleukin-1 type I receptor (IL-1RI) in retinal endothelial cells by enhancing its degradation by a lysosome-dependent mechanism.

Cytokine 20100301

Effect of proteasome inhibitors with different chemical structures on the ubiquitin-proteasome system in vitro.

Veterinary pathology 20100301

Abstracts of the 16th Annual Society on NeuroImmune Pharmacology (SNIP) Conference. April 13-17, 2010. Manhattan Beach, California, USA.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20100301

Proteasome inhibitor lactacystin induces cholinergic degeneration.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20100301

E3 ligase Nedd4 promotes axon branching by downregulating PTEN.

Neuron 20100211

Genetic iron chelation protects against proteasome inhibition-induced dopamine neuron degeneration.

Neurobiology of disease 20100201

Pathogenic mutations cause rapid degradation of lysosomal storage disease-related membrane protein CLN6.

Human mutation 20100201

Hsp40 chaperones promote degradation of the HERG potassium channel.

The Journal of biological chemistry 20100129

Ischaemic preconditioning improves proteasomal activity and increases the degradation of deltaPKC during reperfusion.

Cardiovascular research 20100115

Distinct regulation of insulin receptor substrate-1 and -2 by 90-kDa heat-shock protein in adrenal chromaffin cells.

Neurochemistry international 20100101

The role of zinc in the modulation of neuronal proliferation and apoptosis.

Neurotoxicity research 20100101

Prevention of intracellular degradation of I2020T mutant LRRK2 restores its protectivity against apoptosis.

Biochemical and biophysical research communications 20100101

Translocation of lysosomal cathepsin D caused by oxidative stress or proteasome inhibition in primary cultured neurons and astrocytes.

Biological & pharmaceutical bulletin 20100101

Non-invasive evaluation of nigrostriatal neuropathology in a proteasome inhibitor rodent model of Parkinson's disease.

BMC neuroscience 20100101

Copper downregulates neprilysin activity through modulation of neprilysin degradation.

Journal of Alzheimer's disease : JAD 20100101

Activation of mutant enzyme function in vivo by proteasome inhibitors and treatments that induce Hsp70.

PLoS genetics 20100101

Bortezomib.

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 20100101

The Caenorhabditis elegans Elongator complex regulates neuronal alpha-tubulin acetylation.

PLoS genetics 20100101

TWEAK activates the non-canonical NFkappaB pathway in murine renal tubular cells: modulation of CCL21.

PloS one 20100101

Acute NMDA toxicity in cultured rat cerebellar granule neurons is accompanied by autophagy induction and late onset autophagic cell death phenotype.

BMC neuroscience 20100101

BRCA1 as a Therapeutic Target in Sporadic Epithelial Ovarian Cancer.

Journal of oncology 20100101

Role of STAT3 in in vitro transformation triggered by TRK oncogenes.

PloS one 20100101

Degradation of postsynaptic scaffold GKAP and regulation of dendritic spine morphology by the TRIM3 ubiquitin ligase in rat hippocampal neurons.

PloS one 20100101

Changes in Activity and Kinetic Properties of the Proteasome in Different Rat Organs during Development and Maturation.

Current gerontology and geriatrics research 20100101

Role of the proteasome in excitotoxicity-induced cleavage of glutamic acid decarboxylase in cultured hippocampal neurons.

PloS one 20100101

NF-kappaB/STAT3/PI3K signaling crosstalk in iMyc E mu B lymphoma.

Molecular cancer 20100101

Cellular localization of the herpes simplex virus ICP0 protein dictates its ability to block IRF3-mediated innate immune responses.

PloS one 20100101

Cadmium induces Wnt signaling to upregulate proliferation and survival genes in sub-confluent kidney proximal tubule cells.

Molecular cancer 20100101

Acute effects of the sigma-2 receptor agonist siramesine on lysosomal and extra-lysosomal proteolytic systems in lens epithelial cells.

Molecular vision 20100101

Inhibition of hypoxia-inducible factor-1alpha (HIF-1alpha) protein synthesis by DNA damage inducing agents.

PloS one 20100101

Generating a generation of proteasome inhibitors: from microbial fermentation to total synthesis of salinosporamide a (marizomib) and other salinosporamides.

Marine drugs 20100101

Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10.

PloS one 20100101

Nucleoside drugs induce cellular differentiation by caspase-dependent degradation of stem cell factors.

PloS one 20100101

Anti-inflammatory treatment strategies for ischemia/reperfusion injury in transplantation.

Journal of inflammation (London, England) 20100101

Quercetin targets cysteine string protein (CSPalpha) and impairs synaptic transmission.

PloS one 20100101

Deletion analysis of BMI1 oncoprotein identifies its negative regulatory domain.

Molecular cancer 20100101

Cross-talk between mitochondria and proteasome in Parkinson's disease pathogenesis.

Frontiers in aging neuroscience 20100101

Endoplasmic reticulum stress response in an INS-1 pancreatic beta-cell line with inducible expression of a folding-deficient proinsulin.

BMC cell biology 20100101

Proteomic characterization of an isolated fraction of synthetic proteasome inhibitor (PSI)-induced inclusions in PC12 cells might offer clues to aggresomes as a cellular defensive response against proteasome inhibition by PSI.

BMC neuroscience 20100101

Characterization of the Brain 26S Proteasome and its Interacting Proteins.

Frontiers in molecular neuroscience 20100101

Functional characterization of the protein C A267T mutation: evidence for impaired secretion due to defective intracellular transport.

BMC cell biology 20100101

The WW-HECT protein Smurf2 interacts with the Docking Protein NEDD9/HEF1 for Aurora A activation.

Cell division 20100101

The Enigma of Tripeptidyl-Peptidase II: Dual Roles in Housekeeping and Stress.

Journal of oncology 20100101

Regulation of thromboxane receptor signaling at multiple levels by oxidative stress-induced stabilization, relocation and enhanced responsiveness.

PloS one 20100101

BRCA1 Forms a Functional Complex with γ-H2AX as a Late Response to Genotoxic Stress.

Journal of nucleic acids 20100101

Mutant INS-gene induced diabetes of youth: proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transport.

PloS one 20100101

Monomerization of cytosolic mature smac attenuates interaction with IAPs and potentiation of caspase activation.

PloS one 20100101

Treatment of breast cancer cells with proteasome inhibitor lactacystin increases the level of sensitivity to cell death induced by human immunodeficiency virus type 1.

Biological & pharmaceutical bulletin 20100101

Cell type-specific neuroprotective activity of untranslocated prion protein.

PloS one 20100101

The New Inhibitor of Monoamine Oxidase, M30, has a Neuroprotective Effect Against Dexamethasone-Induced Brain Cell Apoptosis.

Frontiers in neuroscience 20100101

Protogenin, a new member of the immunoglobulin superfamily, is implicated in the development of the mouse lower first molar.

BMC developmental biology 20100101

Deletion or insertion in the first immunoglobulin-plexin-transcription (IPT) domain differentially regulates expression and tumorigenic activities of RON receptor Tyrosine Kinase.

Molecular cancer 20100101

Proteasome inhibition and its therapeutic potential in multiple myeloma.

Biologics : targets & therapy 20100101

Probing the anticancer mechanism of prospective herbal drug Withaferin A on mammals: a case study on human and bovine proteasomes.

BMC genomics 20100101

A novel ER J-protein DNAJB12 accelerates ER-associated degradation of membrane proteins including CFTR.

Cell structure and function 20100101

Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43.

PloS one 20100101

Tocotrienols inhibit lipopolysaccharide-induced pro-inflammatory cytokines in macrophages of female mice.

Lipids in health and disease 20100101

Optimal management of cancer anorexia-cachexia syndrome.

Cancer management and research 20100101

The Relationship between Parkin and Protein Aggregation in Neurodegenerative Diseases.

Frontiers in psychiatry 20100101

Proteasome inhibition increases tau accumulation independent of phosphorylation.

Neurobiology of aging 20091201

Lysosome-dependent degradation of Notch3.

The international journal of biochemistry & cell biology 20091201

Dysfunction of the unfolded protein response increases neurodegeneration in aged rat hippocampus following proteasome inhibition.

Aging cell 20091201

Calcium-dependent plasma membrane repair requires m- or mu-calpain, but not calpain-3, the proteasome, or caspases.

Biochimica et biophysica acta 20091201

The C-terminal region of serotonin transporter is important for its trafficking and glycosylation.

Journal of pharmacological sciences 20091201

Involvement of puromycin-sensitive aminopeptidase in proteolysis of tau protein in cultured cells, and attenuated proteolysis of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) mutant tau.

Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society 20091201

[Classification and synthesis of ubiquitin-proteasome inhibitor].

Yao xue xue bao = Acta pharmaceutica Sinica 20091201

Induction of cross-priming of naive CD8+ T lymphocytes by recombinant bacillus Calmette-Guerin that secretes heat shock protein 70-major membrane protein-II fusion protein.

Journal of immunology (Baltimore, Md. : 1950) 20091115

Recessive hyperekplexia mutations of the glycine receptor alpha1 subunit affect cell surface integration and stability.

Journal of neurochemistry 20091101

z-Leucinyl-leucinyl-norleucinal induces apoptosis of human glioblastoma tumor-initiating cells by proteasome inhibition and mitotic arrest response.

Molecular cancer research : MCR 20091101

The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation.

PLoS pathogens 20091101

The proteasome is an integral part of solar ultraviolet a radiation-induced gene expression.

The Journal of biological chemistry 20091030

The microtubule-targeting agent T0070907 induces proteasomal degradation of tubulin.

Biochemical and biophysical research communications 20091016

Reactive oxygen species decrease cAMP response element binding protein expression in cardiomyocytes via a protein kinase D1-dependent mechanism that does not require Ser133 phosphorylation.

Molecular pharmacology 20091001

Lactacystin requires reactive oxygen species and Bax redistribution to induce mitochondria-mediated cell death.

British journal of pharmacology 20091001

Virus-Induced Chaperone-Enriched (VICE) domains function as nuclear protein quality control centers during HSV-1 infection.

PLoS pathogens 20091001

Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.

The Journal of biological chemistry 20090911

Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling.

Journal of lipid research 20090901

The glucose transporter 2 undergoes plasma membrane endocytosis and lysosomal degradation in a secretagogue-dependent manner.

Endocrinology 20090901

Generation of dopamine neurons with improved cell survival and phenotype maintenance using a degradation-resistant nurr1 mutant.

Stem cells (Dayton, Ohio) 20090901

Limiting transport steps and novel interactions of Connexin-43 along the secretory pathway.

Histochemistry and cell biology 20090901

Role of protease inhibitors and acylation stimulating protein in the adipogenesis in 3T3-L1 cells.

Journal of veterinary science 20090901

Nuclear factor kappaB inhibitors alleviate and the proteasome inhibitor PS-341 exacerbates radiation toxicity in zebrafish embryos.

Molecular cancer therapeutics 20090901

[The role of interferon-gamma in prevention of hydrogen peroxide-induced oxidative injury to vascular endothelium].

Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20090901

A cellular model to monitor proteasome dysfunction by alpha-synuclein.

Biochemistry 20090825

[Dual effects of different concentrations of alpha-synuclein on the neurotoxicity of 6-hydroxydopamine in SH-SY5Y cells].

Sheng li xue bao : [Acta physiologica Sinica] 20090825

Size limitation in translocation of fibroblast growth factor 1 fusion proteins across the endosomal membrane.

Biochemistry 20090804

Nucleus accumbens neurons exhibit synaptic scaling that is occluded by repeated dopamine pre-exposure.

The European journal of neuroscience 20090801

Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene.

Journal of neuroscience research 20090701

An insight into the mechanistic role of p53-mediated autophagy induction in response to proteasomal inhibition-induced neurotoxicity.

Autophagy 20090701

Cyanide-induced death of dopaminergic cells is mediated by uncoupling protein-2 up-regulation and reduced Bcl-2 expression.

Toxicology and applied pharmacology 20090701

The Parkinson disease-associated A30P mutation stabilizes alpha-synuclein against proteasomal degradation triggered by heme oxygenase-1 over-expression in human neuroblastoma cells.

Journal of neurochemistry 20090701

Zinc protoporphyrin inhibition of lipopolysaccharide-, lipoteichoic acid-, and peptidoglycan-induced nitric oxide production through stimulating iNOS protein ubiquitination.

Toxicology and applied pharmacology 20090615

F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage.

Nature 20090604

Role for copper in the cellular and regulatory effects of heme-hemopexin.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20090601

Regulation of podoplanin/PA2.26 antigen expression in tumour cells. Involvement of calpain-mediated proteolysis.

The international journal of biochemistry & cell biology 20090601

Nedd4 mediates ErbB4 JM-a/CYT-1 ICD ubiquitination and degradation in MDCK II cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090601

Partial inhibition of proteasome activity enhances remyelination after cuprizone-induced demyelination.

Experimental neurology 20090601

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1.

Nature cell biology 20090601

Rapamycin down-regulates inducible nitric oxide synthase by inducing proteasomal degradation.

Biological & pharmaceutical bulletin 20090601

Inhibition of lysosomal functions reduces proteasomal activity.

Neuroscience letters 20090529

Enhanced antigen presentation and CTL activity by transduction of mature rather than immature dendritic cells with octaarginine-modified liposomes.

Journal of controlled release : official journal of the Controlled Release Society 20090521

Targeting transcription factor NFkappaB: comparative analysis of proteasome and IKK inhibitors.

Cell cycle (Georgetown, Tex.) 20090515

Nicastrin is dispensable for gamma-secretase protease activity in the presence of specific presenilin mutations.

The Journal of biological chemistry 20090508

Three-dimensional structure-activity relationship study of belactosin A and its stereo- and regioisomers: development of potent proteasome inhibitors by a stereochemical diversity-oriented strategy.

Organic & biomolecular chemistry 20090507

Lactacystin stimulates stellation of cultured rat cortical astrocytes.

Neurochemical research 20090501

Characterization of proteasome inhibition on astrocytes cell cycle.

Journal of molecular neuroscience : MN 20090501

Efficacy on anaplastic thyroid carcinoma of valproic acid alone or in combination with doxorubicin, a synthetic chenodeoxycholic acid derivative, or lactacystin.

International journal of oncology 20090501

Targeting the proteasome pathway.

Expert opinion on therapeutic targets 20090501

Disruption of the ubiquitin proteasome system following axonal stretch injury accelerates progression to secondary axotomy.

Journal of neurotrauma 20090501

Regulation of the stability of cell surface E-cadherin by the proteasome.

Biochemical and biophysical research communications 20090417

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3.

The EMBO journal 20090408

Aldosterone inhibits insulin-induced glucose uptake by degradation of insulin receptor substrate (IRS) 1 and IRS2 via a reactive oxygen species-mediated pathway in 3T3-L1 adipocytes.

Endocrinology 20090401

ARC is a critical cardiomyocyte survival switch in doxorubicin cardiotoxicity.

Journal of molecular medicine (Berlin, Germany) 20090401

Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1.

Cellular signalling 20090401

Low molecular mass polypeptide-2 in human trophoblast: over-expression in hydatidiform moles and possible role in trophoblast cell invasion.

Placenta 20090401

The Mycobacterium tuberculosis phagosome is a HLA-I processing competent organelle.

PLoS pathogens 20090401

A cell cycle timer for asymmetric spindle positioning.

PLoS biology 20090401

Proteasome inhibition induces neurite outgrowth through posttranslational modification of TrkA receptor.

The international journal of biochemistry & cell biology 20090301

Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growth.

Diabetes 20090301

Peptides with dual binding specificity for HLA-A2 and HLA-E are encoded by alternatively spliced isoforms of the antioxidant enzyme peroxiredoxin 5.

International immunology 20090301

TGFbeta prevents proteasomal degradation of the cyclin-dependent kinase inhibitor p27kip1 for cell cycle arrest.

Cell cycle (Georgetown, Tex.) 20090301

Nigral degeneration with inclusion body formation and behavioral changes in rats after proteasomal inhibition.

Stereotactic and functional neurosurgery 20090301

Protective effect against Parkinson's disease-related insults through the activation of XBP1.

Brain research 20090227

Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates.

Molecular cell 20090227

Diastereo- and enantioselective synthesis of beta-hydroxy-alpha-amino acids: application to the synthesis of a key intermediate for lactacystin.

The Journal of organic chemistry 20090220

Inhibition of the 20S proteosome by a protein proteinase inhibitor: evidence that a natural serine proteinase inhibitor can inhibit a threonine proteinase.

Journal of biochemistry 20090201

Proteasome regulation of dynamic transcription factor occupancy on the GnRH-stimulated luteinizing hormone beta-subunit promoter.

Molecular endocrinology (Baltimore, Md.) 20090201

Rift Valley fever virus NSs protein promotes post-transcriptional downregulation of protein kinase PKR and inhibits eIF2alpha phosphorylation.

PLoS pathogens 20090201

Post-translational modification of cyclin A1 is associated with staurosporine and TNFalpha induced apoptosis in leukemic cells.

Molecular and cellular biochemistry 20090101

The host adherens junction molecule nectin-1 is degraded by chlamydial protease-like activity factor (CPAF) in Chlamydia trachomatis-infected genital epithelial cells.

Microbes and infection 20090101

Autophagy contributes to degradation of Hirano bodies.

Autophagy 20090101

Epac mediates PACAP-dependent long-term depression in the hippocampus.

The Journal of physiology 20090101

In vitro activity of bortezomib in cultures of patient tumour cells--potential utility in haematological malignancies.

Medical oncology (Northwood, London, England) 20090101

Antiretroviral-related adipocyte dysfunction and lipodystrophy in HIV-infected patients: Alteration of the PPARγ-dependent pathways.

PPAR research 20090101

Synergistic apoptosis induction in leukemic cells by the phosphatase inhibitor salubrinal and proteasome inhibitors.

PloS one 20090101

Post-translational inhibition of IP-10 secretion in IEC by probiotic bacteria: impact on chronic inflammation.

PloS one 20090101

Post-translational regulation of Oct4 transcriptional activity.

PloS one 20090101

Auto-ubiquitination-induced degradation of MALT1-API2 prevents BCL10 destabilization in t(11;18)(q21;q21)-positive MALT lymphoma.

PloS one 20090101

HIV aspartyl peptidase inhibitors interfere with cellular proliferation, ultrastructure and macrophage infection of Leishmania amazonensis.

PloS one 20090101

The anti-apoptotic activity of BAG3 is restricted by caspases and the proteasome.

PloS one 20090101

Regulation of ErbB2 receptor status by the proteasomal DUB POH1.

PloS one 20090101

Helicobacter pylori induces cancer cell motility independent of the c-Met receptor.

Journal of carcinogenesis 20090101

Proteasome-independent degradation of HIV-1 in naturally non-permissive human placental trophoblast cells.

Retrovirology 20090101

The immunosuppressive properties of the HIV Vpr protein are linked to a single highly conserved residue, R90.

PloS one 20090101

Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP.

PloS one 20090101

Long-term potentiation in isolated dendritic spines.

PloS one 20090101

Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson's disease.

Journal of translational medicine 20090101

Mitogen-activated protein kinases and NFkappaB are involved in SP-A-enhanced responses of macrophages to mycobacteria.

Respiratory research 20090101

Hypoxia-induced transcription of dopamine D3 and D4 receptors in human neuroblastoma and astrocytoma cells.

BMC neuroscience 20090101

The cytotoxicity of gamma-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by gamma-secretase inhibition.

Breast cancer research : BCR 20090101

FoxM1 is a general target for proteasome inhibitors.

PloS one 20090101

50 Hz extremely low frequency electromagnetic fields enhance protein carbonyl groups content in cancer cells: effects on proteasomal systems.

Journal of biomedicine & biotechnology 20090101

Immature and mature species of the human Prostacyclin Receptor are ubiquitinated and targeted to the 26S proteasomal or lysosomal degradation pathways, respectively.

Journal of molecular signaling 20090101

Proteasomal degradation of beta-carotene metabolite--modified proteins.

BioFactors (Oxford, England) 20090101

Investigating bacterial sources of toxicity as an environmental contributor to dopaminergic neurodegeneration.

PloS one 20090101

Notch versus the proteasome: what is the target of gamma-secretase inhibitor-I?

Breast cancer research : BCR 20090101

The C-terminal sequence of RhoB directs protein degradation through an endo-lysosomal pathway.

PloS one 20090101

Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases.

PloS one 20090101

CXCR4 expression heterogeneity in neuroblastoma cells due to ligand-independent regulation.

Molecular cancer 20090101

Discovery of novel proteasome inhibitors using a high-content cell-based screening system.

PloS one 20090101

Ziram causes dopaminergic cell damage by inhibiting E1 ligase of the proteasome.

The Journal of biological chemistry 20081212

ER stress is the initial response to polyglutamine toxicity in PC12 cells.

Biochemical and biophysical research communications 20081212

Structural basis for activation and inhibition of the secreted chlamydia protease CPAF.

Cell host & microbe 20081211

Consequences of the DYT1 mutation on torsinA oligomerization and degradation.

Neuroscience 20081202

Proteasome inhibitor-induced apoptosis is mediated by positive feedback amplification of PKCdelta proteolytic activation and mitochondrial translocation.

Journal of cellular and molecular medicine 20081201

Proteomic analysis of Chlamydia pneumoniae-infected HL cells reveals extensive degradation of cytoskeletal proteins.

FEMS immunology and medical microbiology 20081201

Enhanced killing of androgen-independent prostate cancer cells using inositol hexakisphosphate in combination with proteasome inhibitors.

British journal of cancer 20081104

Induction of BAG2 protein during proteasome inhibitor-induced apoptosis in thyroid carcinoma cells.

British journal of pharmacology 20081101

Study of the effects of proteasome inhibitors on ribosomal protein S19 (RPS19) mutants, identified in patients with Diamond-Blackfan anemia.

Haematologica 20081101

Proteasome-dependent degradation of Chk1 kinase induced by the topoisomerase II inhibitor R16 contributes to its anticancer activity.

Cancer biology & therapy 20081101

Urea-mediated cross-presentation of soluble Epstein-Barr virus BZLF1 protein.

PLoS pathogens 20081101

S-nitrosylation of surfactant protein-D controls inflammatory function.

PLoS biology 20081101

Proteasome affects the expression of aryl hydrocarbon receptor-regulated proteins.

Environmental toxicology and pharmacology 20081101

The ubiquitin-proteasome system is necessary for long-term synaptic depression in Aplysia.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20081008

Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement.

Neurobiology of disease 20081001

The ubiquitin ligase Nedd4 mediates oxidized low-density lipoprotein-induced downregulation of insulin-like growth factor-1 receptor.

American journal of physiology. Heart and circulatory physiology 20081001

c-Jun N-terminal kinase mediates lactacystin-induced dopamine neuron degeneration.

Journal of neuropathology and experimental neurology 20081001

A combination of proteasome inhibitors and antibiotics prevents lethality in a septic shock model.

Innate immunity 20081001

Signal peptide-dependent inhibition of MHC class I heavy chain translation by rhesus cytomegalovirus.

PLoS pathogens 20081001

A new synthetic approach to (+)-lactacystin based on radical cyclisation of enantiopure alpha-ethynyl substituted serine derivatives to 4-methylenepyrrolidinones.

Organic & biomolecular chemistry 20080921

Mitochondria and ubiquitin-proteasomal system interplay: relevance to Parkinson's disease.

Free radical biology & medicine 20080915

Inhibition of proteasome activity blocks Trypanosoma cruzi growth and metacyclogenesis.

Parasitology research 20080901

Insulin potentiates cytokine-induced VCAM-1 expression in human endothelial cells.

Biochimica et biophysica acta 20080901

Regulation of myocardin factor protein stability by the LIM-only protein FHL2.

American journal of physiology. Heart and circulatory physiology 20080901

Nuclear proteasomal degradation and cytoplasmic retention underlie early nuclear exclusion of transcription factor Max upon axon damage.

Experimental neurology 20080901

Kaposi's sarcoma-associated herpesvirus K7 induces viral G protein-coupled receptor degradation and reduces its tumorigenicity.

PLoS pathogens 20080901

Cadmium-induced activation of stress signaling pathways, disruption of ubiquitin-dependent protein degradation and apoptosis in primary rat Sertoli cell-gonocyte cocultures.

Toxicological sciences : an official journal of the Society of Toxicology 20080801

Compounds that increase or mimic cyclic adenosine monophosphate enhance tristetraprolin degradation in lipopolysaccharide-treated murine j774 macrophages.

The Journal of pharmacology and experimental therapeutics 20080801

Angiotensin II type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina.

Diabetes 20080801

The COOH terminus of megalin regulates gene expression in opossum kidney proximal tubule cells.

American journal of physiology. Cell physiology 20080801

Morphine induces ubiquitin-proteasome activity and glutamate transporter degradation.

The Journal of biological chemistry 20080801

Superoxide-mediated proteasomal degradation of Bcl-2 determines cell susceptibility to Cr(VI)-induced apoptosis.

Carcinogenesis 20080801

Pramipexole has astrocyte-mediated neuroprotective effects against lactacystin toxicity.

Neuroscience letters 20080801

Efficient MHC class I presentation by controlled intracellular trafficking of antigens in octaarginine-modified liposomes.

Molecular therapy : the journal of the American Society of Gene Therapy 20080801

Formation of cholesterol-enriched structures by aberrant intracellular accumulation of ATP-binding cassette transporter A1.

Genes to cells : devoted to molecular & cellular mechanisms 20080801

Nurr1 deficiency predisposes to lactacystin-induced dopaminergic neuron injury in vitro and in vivo.

Brain research 20080730

Synthesis and proteasome inhibition of glycyrrhetinic acid derivatives.

Bioorganic & medicinal chemistry 20080715

Ornithine decarboxylase interferes with macrophage-like differentiation and matrix metalloproteinase-9 expression by tumor necrosis factor alpha via NF-kappaB.

Leukemia research 20080701

Dequalinium-induced cell death of yeast expressing alpha-synuclein-GFP fusion protein.

Neurochemical research 20080701

TrkA receptor endolysosomal degradation is both ubiquitin and proteasome dependent.

Traffic (Copenhagen, Denmark) 20080701

Multiple molecular pathways are involved in the neuroprotection of GDNF against proteasome inhibitor induced dopamine neuron degeneration in vivo.

Experimental biology and medicine (Maywood, N.J.) 20080701

Proteasomal degradation of IRS-2, but not IRS-1 by calcineurin inhibition: attenuation of insulin-like growth factor-I-induced GSK-3beta and ERK pathways in adrenal chromaffin cells.

Neuropharmacology 20080701

Proteasome inhibition suppresses essential immune functions of human CD4+ T cells.

Immunology 20080601

The intracellular accumulation of polymeric neuroserpin explains the severity of the dementia FENIB.

Human molecular genetics 20080601

Carbon monoxide decreases the level of iNOS protein and active dimer in IL-1beta-stimulated hepatocytes.

Nitric oxide : biology and chemistry 20080601

Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson's disease.

Journal of neurochemistry 20080601

Rescue of mutant alpha-galactosidase A in the endoplasmic reticulum by 1-deoxygalactonojirimycin leads to trafficking to lysosomes.

Biochimica et biophysica acta 20080601

NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33(ING1b).

EMBO reports 20080601

Comparison of neuroprotective and neurorestorative capabilities of rasagiline and selegiline against lactacystin-induced nigrostriatal dopaminergic degeneration.

Journal of neurochemistry 20080601

Proteasomal abnormalities in cortical Lewy body disease and the impact of proteasomal inhibition within cortical and cholinergic systems.

Journal of neural transmission (Vienna, Austria : 1996) 20080601

Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways.

Cellular signalling 20080601

Zinc adaptation and resistance to cadmium toxicity in mammalian cells: molecular insight by proteomic analysis.

Proteomics 20080601

Natural compounds with proteasome inhibitory activity for cancer prevention and treatment.

Current protein & peptide science 20080601

A green tea component suppresses posttranslational expression of basic fibroblast growth factor in colorectal cancer.

Gastroenterology 20080601

Protein degradation, as with protein synthesis, is required during not only long-term spatial memory consolidation but also reconsolidation.

The European journal of neuroscience 20080601

Water and ion channels: crucial in the initiation and progression of apoptosis in central nervous system?

Current neuropharmacology 20080601

Regulation of Akt mRNA and protein levels by glycogen synthase kinase-3beta in adrenal chromaffin cells: effects of LiCl and SB216763.

European journal of pharmacology 20080531

Proteasomes cleave at multiple sites within polyglutamine tracts: activation by PA28gamma(K188E).

The Journal of biological chemistry 20080509

Promotion of neurite outgrowth by fibroblast growth factor receptor 1 overexpression and lysosomal inhibition of receptor degradation in pheochromocytoma cells and adult sensory neurons.

Neuroscience 20080502

Proteasome inhibitors remarkably prevent translesion replication in cancer cells but not normal cells.

Cancer science 20080501

Inhibition of plasminogen activator inhibitor-1 expression in vascular smooth muscle cells by protoporphyrins through a heme oxygenase-independent mechanism.

Molecular and cellular biochemistry 20080501

Simultaneous presentation and cross-presentation of immune-stimulating complex-associated cognate antigen by antigen-specific B cells.

European journal of immunology 20080501

Practical synthesis of a key intermediate for lactacystin from (R)-4-hydroxymethyl-2-phenyl-4,5-dihydrooxazol-4-ylmethyl acetate.

Chemical & pharmaceutical bulletin 20080501

Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction.

PLoS pathogens 20080501

Human immunodeficiency virus type 1 gp120-mediated disruption of tight junction proteins by induction of proteasome-mediated degradation of zonula occludens-1 and -2 in human brain microvascular endothelial cells.

Journal of neurovirology 20080501

Caffeine induces cell death via activation of apoptotic signal and inactivation of survival signal in human osteoblasts.

International journal of molecular sciences 20080501

BV-2 stimulation by lactacystin results in a strong inflammatory reaction and apoptotic neuronal death in SH-SY5Y cells.

Brain research 20080418

Agonist-specific down regulation of mu-opioid receptors: Different cellular pathways are activated by different opioid agonists.

Life sciences 20080409

Steroidogenic activity of StAR requires contact with mitochondrial VDAC1 and phosphate carrier protein.

The Journal of biological chemistry 20080404

Enantioselective total syntheses of omuralide, 7-epi-omuralide, and (+)-lactacystin.

The Journal of organic chemistry 20080321

Unsaturated lipid peroxidation-derived aldehydes activate autophagy in vascular smooth-muscle cells.

The Biochemical journal 20080315

Prevention of deoxycholate-induced gastric apoptosis by aspirin: roles of NF-kappaB and PKC signaling.

The Journal of surgical research 20080301

Arkadia regulates TGF-beta signaling during renal tubular epithelial to mesenchymal cell transition.

Kidney international 20080301

Proteasome inhibition: an early or late event in nitric oxide-induced neuronal death?

Nitric oxide : biology and chemistry 20080301

Effect of an experimental proteasome inhibitor on the cytoskeleton, cytosolic protein turnover, and induction in the neuronal cells in vitro.

Neurotoxicology 20080301

Mitogen-activated protein kinase kinase 4/c-Jun NH2-terminal kinase kinase 1 protein expression is subject to translational regulation in prostate cancer cell lines.

Molecular cancer research : MCR 20080301

A 39 kDa fragment of endogenous ASK1 suggests specific cleavage not degradation by the proteasome.

IUBMB life 20080301

Yessotoxin inhibits the complete degradation of E-cadherin.

Toxicology 20080227

Proteasomal inhibition and apoptosis regulatory changes in human isolated lymphocytes: the synergistic role of dopamine.

Journal of cellular biochemistry 20080215

Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response.

Aging cell 20080201

Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway.

Traffic (Copenhagen, Denmark) 20080201

Immunocytochemical analysis for intracellular dynamics of C1GalT associated with molecular chaperone, Cosmc.

Biochemical and biophysical research communications 20080201

Protein quality control: the who's who, the where's and therapeutic escapes.

Histochemistry and cell biology 20080201

Cyclic AMP-dependent proteolysis of GATA-6 expressed on the intracellular membrane.

Cell biology international 20080201

Oxidative injury induces selective rather than global inhibition of proteasomal activity.

Journal of molecular and cellular cardiology 20080201

LPS induces the TNF-alpha-mediated downregulation of rat liver aquaporin-8: role in sepsis-associated cholestasis.

American journal of physiology. Gastrointestinal and liver physiology 20080201

Sensitivity of tumor cells to proteasome inhibitors is associated with expression levels and composition of proteasome subunits.

Cancer 20080201

Efficient total synthesis of novel bioactive microbial metabolites.

Accounts of chemical research 20080201

Nitric oxide-dependent proteasomal degradation of cytochrome P450 2B proteins.

The Journal of biological chemistry 20080111

Hsp90-mediated cytosolic refolding of exogenous proteins internalized by dendritic cells.

The EMBO journal 20080109

Neonatal and adult microglia cross-present exogenous antigens.

Glia 20080101

Constitutive activation of c-Met is correlated with c-Met overexpression and dependent on cell-matrix adhesion in lung adenocarcinoma cell lines.

Cancer science 20080101

Oncostatin M induces growth arrest of skeletal muscle cells in G1 phase by regulating cyclin D1 protein level.

Cellular signalling 20080101

Cross-presentation of NY-ESO-1 cytotoxic T lymphocyte epitope fused to human heat shock cognate protein 70 by dendritic cells.

Cancer science 20080101

Metabolic and morphological alterations induced by proteolysis-inducing factor from Walker tumour-bearing rats in C2C12 myotubes.

BMC cancer 20080101

Hsc70 focus formation at the periphery of HSV-1 transcription sites requires ICP27.

PloS one 20080101

Alterations in the Notch4 pathway in cerebral endothelial cells by the HIV aspartyl protease inhibitor, nelfinavir.

BMC neuroscience 20080101

Expression of K6W-ubiquitin in lens epithelial cells leads to upregulation of a broad spectrum of molecular chaperones.

Molecular vision 20080101

Excessive islet NO generation in type 2 diabetic GK rats coincides with abnormal hormone secretion and is counteracted by GLP-1.

PloS one 20080101

Marine actinomycetes: a new source of compounds against the human malaria parasite.

PloS one 20080101

Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumour activity in neuroblastoma cells.

Molecular cancer 20080101

Ubiquitination is required for effective replication of coxsackievirus B3.

PloS one 20080101

AIP4/Itch regulates Notch receptor degradation in the absence of ligand.

PloS one 20080101

Supernatant from bifidobacterium differentially modulates transduction signaling pathways for biological functions of human dendritic cells.

PloS one 20080101

Comprehensive study of proteasome inhibitors against Plasmodium falciparum laboratory strains and field isolates from Gabon.

Malaria journal 20080101

Changes in ocular aquaporin-4 (AQP4) expression following retinal injury.

Molecular vision 20080101

Bifidobacterium strains suppress in vitro the pro-inflammatory milieu triggered by the large intestinal microbiota of coeliac patients.

Journal of inflammation (London, England) 20080101

Targeting the UPS as therapy in multiple myeloma.

BMC biochemistry 20080101

The UPS: a promising target for breast cancer treatment.

BMC biochemistry 20080101

Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity.

Molecular brain 20080101

Modulation of the NF-kappaB pathway by Bordetella pertussis filamentous hemagglutinin.

PloS one 20080101

Differential role of beta-arrestin ubiquitination in agonist-promoted down-regulation of M1 vs M2 muscarinic acetylcholine receptors.

Journal of molecular signaling 20080101

Reduction of infectious bursal disease virus replication in cultured cells by proteasome inhibitors.

Virus genes 20071201

Prevention and restoration of lactacystin-induced nigrostriatal dopamine neuron degeneration by novel brain-permeable iron chelators.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20071201

Endoplasmic reticulum-associated degradation of growth hormone receptor in Janus kinase 2-deficient cells.

Endocrinology 20071201

PPARalpha agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS-treated macrophages.

British journal of pharmacology 20071201

Linkage of curcumin-induced cell cycle arrest and apoptosis by cyclin-dependent kinase inhibitor p21(/WAF1/CIP1).

Cell cycle (Georgetown, Tex.) 20071201

NSAIDs enhance proteasomic degradation of survivin, a mechanism of gastric epithelial cell injury and apoptosis.

Biochemical pharmacology 20071115

Parkinson's disease genetic mutations increase cell susceptibility to stress: mutant alpha-synuclein enhances H2O2- and Sin-1-induced cell death.

Neurobiology of aging 20071101

4-Hydroxy-2-nonenal increases superoxide anion radical in endothelial cells via stimulated GTP cyclohydrolase proteasomal degradation.

Arteriosclerosis, thrombosis, and vascular biology 20071101

Proteasome inhibitor lactacystin ablates liver injury induced by intestinal ischaemia-reperfusion.

Clinical and experimental pharmacology & physiology 20071101

Dendritic cells process antigens encapsulated in a biodegradable polymer, poly(D,L-lactide-co-glycolide), via an alternate class I MHC processing pathway.

Archives of pharmacal research 20071101

Human GCIP interacts with CT847, a novel Chlamydia trachomatis type III secretion substrate, and is degraded in a tissue-culture infection model.

Cellular microbiology 20071001

Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products.

Blood 20071001

Cellular Zn2+ chelators cause 'dying-back' neurite degeneration associated with energy impairment.

Journal of neuroscience research 20071001

The proteasome and intracellular redox status: implications for apoptotic regulation in lens epithelial cells.

Current eye research 20071001

Treatment of PC12 cells with nerve growth factor induces proteasomal degradation of T-cadherin that requires tyrosine phosphorylation of its cadherin domain.

The Journal of biological chemistry 20070914

The neuroprotective role of attractin in neurodegeneration.

Neurobiology of aging 20070901

Cell cycle arrest and apoptosis induced by the coronavirus infectious bronchitis virus in the absence of p53.

Virology 20070901

Splicing factor SF3b as a target of the antitumor natural product pladienolide.

Nature chemical biology 20070901

Glial cell-derived neurotrophic factor protects against proteasome inhibition-induced dopamine neuron degeneration by suppression of endoplasmic reticulum stress and caspase-3 activation.

The journals of gerontology. Series A, Biological sciences and medical sciences 20070901

Hepatitis C virus induces E6AP-dependent degradation of the retinoblastoma protein.

PLoS pathogens 20070901

Downregulation of parkin damages antioxidant defenses and enhances proteasome inhibition-induced toxicity in PC12 cells.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20070901

Future therapeutic treatment of COPD: struggle between oxidants and cytokines.

International journal of chronic obstructive pulmonary disease 20070901

A directed approach for engineering conditional protein stability using biologically silent small molecules.

The Journal of biological chemistry 20070824

Photobleaching reveals complex effects of inhibitors on transcribing RNA polymerase II in living cells.

Experimental cell research 20070815

Differential endoplasmic reticulum stress signaling pathways mediated by iNOS.

Biochemical and biophysical research communications 20070803

Proteasomes and RARS modulate AIMP1/EMAP II secretion in human cancer cell lines.

Journal of cellular physiology 20070801

Ubiquitination is involved in glucose-mediated downregulation of GIP receptors in islets.

American journal of physiology. Endocrinology and metabolism 20070801

Beta-amyloid (25-35) enhances lipid metabolism and protein ubiquitination in cultured neurons.

Journal of neuroscience research 20070801

Membrane cytosolic translocation of verotoxin A1 subunit in target cells.

Microbiology (Reading, England) 20070801

Mechanisms of induction of endothelial cell E-selectin expression by smooth muscle cells and its inhibition by shear stress.

Blood 20070715

Determinants of growth hormone receptor down-regulation.

Molecular endocrinology (Baltimore, Md.) 20070701

Downregulation of p63 upon exposure to bile salts and acid in normal and cancer esophageal cells in culture.

American journal of physiology. Gastrointestinal and liver physiology 20070701

Specific blockage of ligand-induced degradation of the Ah receptor by proteasome but not calpain inhibitors in cell culture lines from different species.

Biochemical pharmacology 20070630

Requirement for the dynein light chain km23-1 in a Smad2-dependent transforming growth factor-beta signaling pathway.

The Journal of biological chemistry 20070629

Novel tetra-acridine derivatives as dual inhibitors of topoisomerase II and the human proteasome.

Biochemical pharmacology 20070615

Inhibiting proteasomal degradation of microsomal triglyceride transfer protein prevents CCl4-induced steatosis.

The Journal of biological chemistry 20070608

Docosahexaenoic acid induces proteasome-dependent degradation of beta-catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2.

Carcinogenesis 20070601

Localization of proteasomes and proteasomal proteolysis in the mammalian interphase cell nucleus by systematic application of immunocytochemistry.

Histochemistry and cell biology 20070601

Protective role for nitric oxide during the endoplasmic reticulum stress response in pancreatic beta-cells.

American journal of physiology. Endocrinology and metabolism 20070601

Endoplasmic reticulum stress-induced cell death mediated by the proteasome.

Cell death and differentiation 20070601

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

Nature chemical biology 20070601

Low expression of cell-surface thromboxane A2 receptor beta-isoform through the negative regulation of its membrane traffic by proteasomes.

Prostaglandins & other lipid mediators 20070601

Real-time fluorescence detection of ERAD substrate retrotranslocation in a mammalian in vitro system.

Cell 20070601

Adrenoleukodystrophy: subcellular localization and degradation of adrenoleukodystrophy protein (ALDP/ABCD1) with naturally occurring missense mutations.

Journal of neurochemistry 20070601

Proteasome inhibitor lactacystin disturbs the intracellular calcium homeostasis of dopamine neurons in ventral mesencephalic cultures.

Neurochemistry international 20070601

A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase delta.

The Journal of biological chemistry 20070525

Protein kinase C-ERK1/2 signal pathway switches glucose depletion-induced necrosis to apoptosis by regulating superoxide dismutases and suppressing reactive oxygen species production in A549 lung cancer cells.

Journal of cellular physiology 20070501

Degradation of nicastrin involves both proteasome and lysosome.

Journal of neurochemistry 20070501

Smac-mediated sensitization of human B-lymphoma cells to staurosporine- and lactacystin-triggered apoptosis is apoptosome-dependent.

Leukemia 20070501

Analysis of nucleolar protein dynamics reveals the nuclear degradation of ribosomal proteins.

Current biology : CB 20070501

Attenuation of muscle atrophy in a murine model of cachexia by inhibition of the dsRNA-dependent protein kinase.

British journal of cancer 20070423

Post-induction, stimulus-specific regulation of tumor necrosis factor mRNA expression.

The Journal of biological chemistry 20070420

Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes.

The Journal of biological chemistry 20070420

Effects of tau phosphorylation on proteasome activity.

FEBS letters 20070403

Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines.

Biochemical pharmacology 20070401

Distinct roles of fibroblast growth factor receptor 1 and 2 in regulating cell survival and epithelial-mesenchymal transition.

Molecular endocrinology (Baltimore, Md.) 20070401

Lafora disease proteins malin and laforin are recruited to aggresomes in response to proteasomal impairment.

Human molecular genetics 20070401

Phorbol esters induce intracellular accumulation of the anti-apoptotic protein PED/PEA-15 by preventing ubiquitinylation and proteasomal degradation.

The Journal of biological chemistry 20070323

CD1d degradation in Chlamydia trachomatis-infected epithelial cells is the result of both cellular and chlamydial proteasomal activity.

The Journal of biological chemistry 20070309

Regulation of STIM1, store-operated Ca2+ influx, and nitric oxide generation by retinoic acid in rat mesangial cells.

American journal of physiology. Renal physiology 20070301

Posttranscriptional inhibition of interferon-gamma production by lead.

Toxicological sciences : an official journal of the Society of Toxicology 20070301

Overexpression of lentivirus-mediated glial cell line-derived neurotrophic factor in bone marrow stromal cells and its neuroprotection for the PC12 cells damaged by lactacystin.

Neuroscience bulletin 20070301

Activation of transcription factors by extracellular nucleotides in immune and related cell types.

Purinergic signalling 20070301

Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress: relevance to Parkinson disease.

The Journal of biological chemistry 20070216

Human endoplasmic reticulum mannosidase I is subject to regulated proteolysis.

The Journal of biological chemistry 20070216

Ischemia promotes calpain-mediated degradation of p120-catenin in SH-SY5Y cells.

Biochemical and biophysical research communications 20070216

Green tea polyphenol (-) -epigallocatechin-3-gallate promotes the rapid protein kinase C- and proteasome-mediated degradation of Bad: implications for neuroprotection.

Journal of neurochemistry 20070201

Cinnabaramides A-G: analogues of lactacystin and salinosporamide from a terrestrial streptomycete.

Journal of natural products 20070201

Transforming growth factor-beta, estrogen, and progesterone converge on the regulation of p27Kip1 in the normal and malignant endometrium.

Cancer research 20070201

Total synthesis of lactacystin and salinosporamide A.

Chemistry, an Asian journal 20070108

Proteasome dysfunction inhibits surfactant protein gene expression in lung epithelial cells: mechanism of inhibition of SP-B gene expression.

American journal of physiology. Lung cellular and molecular physiology 20070101

Isolation and characterization of mammalian D-aspartyl endopeptidase.

Amino acids 20070101

Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients.

Biochemical pharmacology 20070101

Inhibition of human preadipocyte proteasomal activity by HIV protease inhibitors or specific inhibitor lactacystin leads to a defect in adipogenesis, which involves matrix metalloproteinase-9.

The Journal of pharmacology and experimental therapeutics 20070101

Proteasomal chymotrypsin-like peptidase activity is required for essential functions of human monocyte-derived dendritic cells.

Immunology 20070101

Optimal determination of heart tissue 26S-proteasome activity requires maximal stimulating ATP concentrations.

Journal of molecular and cellular cardiology 20070101

Proteolytic mechanisms underlying mitochondrial degradation in the ocular lens.

Investigative ophthalmology & visual science 20070101

Are heat shock proteins therapeutic target for Parkinson's disease?

International journal of biological sciences 20070101

Proteasome inhibitors in the clinical setting: benefits and strategies to overcome multiple myeloma resistance to proteasome inhibitors.

Drugs in R&D 20070101

Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistance.

Molecular cancer 20070101

Proteasome activator enhances survival of Huntington's disease neuronal model cells.

PloS one 20070101

Role of ubiquitination in IGF-1 receptor signaling and degradation.

PloS one 20070101

The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention.

Molecular cancer 20070101

Hook2 contributes to aggresome formation.

BMC cell biology 20070101

Characterization of novel transforming growth factor-beta type I receptors found in malignant pleural effusion tumor cells.

BMC molecular biology 20070101

The N-terminal 15-48 region of cyclin kinase inhibitor p21 is a determinant of basal expression.

Cancer genomics & proteomics 20070101

Evidence for paternal leakage in hybrid periodical cicadas (Hemiptera: Magicicada spp.).

PloS one 20070101

Antimalarial activity of the anticancer and proteasome inhibitor bortezomib and its analog ZL3B.

BMC clinical pharmacology 20070101

The possible role of the ubiquitin proteasome system in the development of atherosclerosis in diabetes.

Cardiovascular diabetology 20070101

Role of the ubiquitin proteasome system in Parkinson's disease.

BMC biochemistry 20070101

The ubiquitin proteasome system in Huntington's disease and the spinocerebellar ataxias.

BMC biochemistry 20070101

Role of proteasomes in disease.

BMC biochemistry 20070101

Cells of the synovium in rheumatoid arthritis. Synovial fibroblasts.

Arthritis research & therapy 20070101

Sustained stress response after oxidative stress in trabecular meshwork cells.

Molecular vision 20070101

The proteasome inhibitor lactacystin attenuates growth and migration of vascular smooth muscle cells and limits the response to arterial injury.

Experimental and clinical cardiology 20070101

Need for tripeptidyl-peptidase II in major histocompatibility complex class I viral antigen processing when proteasomes are detrimental.

The Journal of biological chemistry 20061229

The ubiquitin ligase itch is auto-ubiquitylated in vivo and in vitro but is protected from degradation by interacting with the deubiquitylating enzyme FAM/USP9X.

The Journal of biological chemistry 20061215

Effect of proteasome inhibition on toxicity and CYP3A23 induction in cultured rat hepatocytes: comparison with arsenite.

Toxicology and applied pharmacology 20061215

Gastrointestinal hormones cause rapid c-Met receptor down-regulation by a novel mechanism involving clathrin-mediated endocytosis and a lysosome-dependent mechanism.

The Journal of biological chemistry 20061208

Comparison of the neurotoxic effects of proteasomal inhibitors in primary mesencephalic cultures.

Experimental neurology 20061201

Ubiquitin-proteasome pathway mediates degradation of APH-1.

Journal of neurochemistry 20061201

Regulation of catechol-O-methyltransferase expression in human myometrial cells.

Obstetrics and gynecology 20061201

The proteasome as a potential target for novel anticancer drugs and chemosensitizers.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20061201

The internalization and degradation of human copper transporter 1 following cisplatin exposure.

Cancer research 20061115

Lactacystin inhibits 3T3-L1 adipocyte differentiation through induction of CHOP-10 expression.

Biochemical and biophysical research communications 20061110

Lactacystin decreases amyloid-beta peptide production by inhibiting beta-secretase activity.

Journal of neuroscience research 20061101

Proteasome inhibition attenuates lung injury induced by intestinal ischemia reperfusion in rats.

Life sciences 20061026

A novel proteasome inhibitor NPI-0052 as an anticancer therapy.

British journal of cancer 20061023

Differential effects of NF-kappaB on apoptosis induced by DNA-damaging agents: the type of DNA damage determines the final outcome.

Oncogene 20061012

OPG/membranous--RANKL complex is internalized via the clathrin pathway before a lysosomal and a proteasomal degradation.

Bone 20061001

Constitutive activity of glycogen synthase kinase-3beta: positive regulation of steady-state levels of insulin receptor substrates-1 and -2 in adrenal chromaffin cells.

Brain research 20060919

Codon optimized expression of HPV 16 E6 renders target cells susceptible to E6-specific CTL recognition.

Immunology letters 20060915

PTEN is recruited to specific microdomains of the plasma membrane during lactacystin-induced neuronal apoptosis.

Neuroscience letters 20060911

Photic regulation of arylalkylamine N-acetyltransferase binding to 14-3-3 proteins in retinal photoreceptor cells.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20060906

Release of iron from ferritin requires lysosomal activity.

American journal of physiology. Cell physiology 20060901

A targeted protease substrate for a quantitative determination of protease activities in the endolysosomal pathway.

Chembiochem : a European journal of chemical biology 20060901

Akt and Mammalian target of rapamycin regulate separate systems of proteolysis in renal tubular cells.

Journal of the American Society of Nephrology : JASN 20060901

Cyclic AMP delays neutrophil apoptosis via stabilization of Mcl-1.

FEBS letters 20060821

Degradation of insulin-like growth factor-I receptor occurs via ubiquitin-proteasome pathway in human lung cancer cells.

Journal of cellular physiology 20060801

Cbl and Akt regulate CXCL8-induced and CXCR1- and CXCR2-mediated chemotaxis.

International immunology 20060801

Role of heat shock response and Hsp27 in mutant SOD1-dependent cell death.

Experimental neurology 20060801

The antiapoptotic effect of heme oxygenase-1 in endothelial cells involves the degradation of p38 alpha MAPK isoform.

Journal of immunology (Baltimore, Md. : 1950) 20060801

Prediction of the mechanism of action of omuralide (clasto-lactacystin beta-lactone) on human cathepsin A based on a structural model of the yeast proteasome beta5/PRE2-subunit/omuralide complex.

Biochimica et biophysica acta 20060801

Overlapping functions of argonaute proteins in patterning and morphogenesis of Drosophila embryos.

PLoS genetics 20060801

Lysophosphatidic acid stimulates PC-3 prostate cancer cell Matrigel invasion through activation of RhoA and NF-kappaB activity.

Molecular carcinogenesis 20060701

Regulation of proteolysis by cytokines in the human intestinal epithelial cell line HCT-8: role of IFNgamma.

Biochimie 20060701

Secreted proteins from Mycobacterium tuberculosis gain access to the cytosolic MHC class-I antigen-processing pathway.

Journal of immunology (Baltimore, Md. : 1950) 20060701

Cellular stability of Rho-GTPases glucosylated by Clostridium difficile toxin B.

FEBS letters 20060612

Accumulation of the pro-apoptotic factor Bak is controlled by antagonist factor Mcl-1 availability.

Apoptosis : an international journal on programmed cell death 20060601

Ceramides reduce CD36 cell surface expression and oxidised LDL uptake by monocytes and macrophages.

Archives of biochemistry and biophysics 20060601

Proteasome-mediated regulation of CpG DNA- and peptidoglycan-induced cytokines, inflammatory genes, and mitogen-activated protein kinase activation.

Shock (Augusta, Ga.) 20060601

Involvement of the paxillin pathway in JB6 Cl41 cell transformation.

Cancer research 20060601

PU.1 is degraded in differentiation of erythrocytes through a proteasome-dependent pathway.

DNA and cell biology 20060601

Alpha,beta-unsaturated beta-silyl imide substrates for catalytic, enantioselective conjugate additions: a total synthesis of (+)-lactacystin and the discovery of a new proteasome inhibitor.

Journal of the American Chemical Society 20060531

Induction of protein degradation in skeletal muscle by a phorbol ester involves upregulation of the ubiquitin-proteasome proteolytic pathway.

Life sciences 20060515

Proteasomal inhibition hypersensitizes differentiated neuroblastoma cells to oxidative damage.

Neuroscience letters 20060515

Protective role of heat shock and heat shock protein 70 in lactacystin-induced cell death both in the rat substantia nigra and PC12 cells.

Brain research 20060504

Activation of NFkappaB and Ub-proteasome pathway during apoptosis induced by a serum factor is mediated through the upregulation of the 26S proteasome subunits.

Apoptosis : an international journal on programmed cell death 20060501

Lactacystin exhibits potent anti-tumor activity in an animal model of malignant glioma when administered via controlled-release polymers.

Journal of neuro-oncology 20060501

The involvement of glycogen synthase kinase-3 and protein phosphatase-2A in lactacystin-induced tau accumulation.

FEBS letters 20060501

Role of the proteasome in TGF-beta signaling in lens epithelial cells.

Investigative ophthalmology & visual science 20060501

Evidence for a role of the ubiquitin-proteasome pathway in pancreatic islets.

Diabetes 20060501

Key inflammatory signaling pathways are regulated by the proteasome.

Shock (Augusta, Ga.) 20060501

Ubiquitin-dependent degradation of p53 protein despite phosphorylation at its N terminus by acetaminophen.

The Journal of pharmacology and experimental therapeutics 20060401

Catabolism of endogenous and overexpressed APH1a and PEN2: evidence for artifactual involvement of the proteasome in the degradation of overexpressed proteins.

The Biochemical journal 20060301

Proteasome blockade exerts an antifibrotic activity by coordinately down-regulating type I collagen and tissue inhibitor of metalloproteinase-1 and up-regulating metalloproteinase-1 production in human dermal fibroblasts.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060301

Characterization of a neural-specific splicing form of the human neuregulin 3 gene involved in oligodendrocyte survival.

Journal of cell science 20060301

Constitutively expressed catalytic proteasomal subunits are up-regulated during neuronal differentiation and required for axon initiation, elongation and maintenance.

Journal of neurochemistry 20060301

The BTB-kelch protein LZTR-1 is a novel Golgi protein that is degraded upon induction of apoptosis.

The Journal of biological chemistry 20060224

Involvement of the ubiquitin pathway in decreasing Ku70 levels in response to drug-induced apoptosis.

Experimental cell research 20060215

Catalytic asymmetric total synthesis of (+)-lactacystin.

The Journal of organic chemistry 20060203

Beta-adrenergic receptor trafficking by exercise in rat adipocytes: roles of G-protein-coupled receptor kinase-2, beta-arrestin-2, and the ubiquitin-proteasome pathway.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060201

Heat shock protein 90 is an essential molecular chaperone for nuclear transport of glucocorticoid receptor beta.

Investigative ophthalmology & visual science 20060201

Regulation of survivin by ErbB2 signaling: therapeutic implications for ErbB2-overexpressing breast cancers.

Cancer research 20060201

E6AP and calmodulin reciprocally regulate estrogen receptor stability.

The Journal of biological chemistry 20060127

Neurotrophic factors increase tumor necrosis factor-alpha-induced nuclear translocation of NF-kappaB in rat PC12 cells.

Neuroscience letters 20060116

NF-kappaB activation is required for cisplatin-induced apoptosis in head and neck squamous carcinoma cells.

FEBS letters 20060109

Posttranscriptional control of aquaporin-2 abundance by vasopressin in renal collecting duct principal cells.

American journal of physiology. Renal physiology 20060101

Oxidative stress response results in increased p21WAF1/CIP1 degradation in cystic fibrosis lung epithelial cells.

Free radical biology & medicine 20060101

Proteasome mediates removal of proteins oxidized during myocardial ischemia.

Free radical biology & medicine 20060101

Geldanamycin stimulates internalization of ErbB2 in a proteasome-dependent way.

Journal of cell science 20060101

Selective relocalization and proteasomal downregulation of PKCalpha induced by platelet-activating factor in retinal pigment epithelium.

Investigative ophthalmology & visual science 20060101

Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells.

Molecular cancer 20060101

A single point mutation in the low-density lipoprotein receptor switches the degradation of its mature protein from the proteasome to the lysosome.

The international journal of biochemistry & cell biology 20060101

3-phosphoinositide-dependent protein kinase-1 (PDK1) promotes invasion and activation of matrix metalloproteinases.

BMC cancer 20060101

Cyclooxygenase expression is not required for release of arachidonic acid from cells by some nonsteroidal anti-inflammatory drugs and cancer preventive agents.

BMC pharmacology 20060101

Activation and degradation of protein C by primary rabbit pleural mesothelial cells.

Lung 20060101

Porcine congenital splayleg is characterised by muscle fibre atrophy associated with relative rise in MAFbx and fall in P311 expression.

BMC veterinary research 20060101

Phenotypical characteristics, biochemical pathways, molecular targets and putative role of nitric oxide-mediated programmed cell death in Leishmania.

Parasitology 20060101

Silvestrol regulates G2/M checkpoint genes independent of p53 activity.

Anticancer research 20060101

Serine phosphorylation regulates paxillin turnover during cell migration.

Cell communication and signaling : CCS 20060101

Detection of a proteasome in Pneumocystis carinii and its modulation by specific proteasome inhibitors.

The Journal of eukaryotic microbiology 20060101

Copper regulated synthesis, secretion and degradation of ceruloplasmin in a mouse immortalized hepatocytic cell line.

Cellular and molecular biology (Noisy-le-Grand, France) 20051231

Regulation of cytochrome P450 2E1 by heat shock protein 90-dependent stabilization and CHIP-dependent proteasomal degradation.

Biochemistry 20051213

Regulation of cellular caveolin-1 protein expression in murine macrophages by microbial products.

Infection and immunity 20051201

Combination of proteasomal inhibitors lactacystin and MG132 induced synergistic apoptosis in prostate cancer cells.

Neoplasia (New York, N.Y.) 20051201

Disease-related prion protein forms aggresomes in neuronal cells leading to caspase activation and apoptosis.

The Journal of biological chemistry 20051118

Proteasome inhibition induces selective motor neuron death in organotypic slice cultures.

Journal of neuroscience research 20051115

Destabilization of Krüppel-like factor 4 protein in response to serum stimulation involves the ubiquitin-proteasome pathway.

Cancer research 20051115

Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides.

The Journal of biological chemistry 20051111

Role of ubiquitin-proteasome degradation pathway in biogenesis efficiency of {beta}-cell ATP-sensitive potassium channels.

American journal of physiology. Cell physiology 20051101

Induction and attenuation of neuronal apoptosis by proteasome inhibitors in murine cortical cell cultures.

Journal of neurochemistry 20051101

UV-A light regulation of arylalkylamine N-acetyltransferase activity in the chick pineal gland: role of cAMP and proteasomal proteolysis.

Journal of pineal research 20051101

Jak2 tyrosine kinase prevents angiotensin II-mediated inositol 1,4,5 trisphosphate receptor degradation.

Vascular pharmacology 20051101

Anti-angiogenic and anti-tumor properties of proteasome inhibitors.

Current cancer drug targets 20051101

A formal synthesis of (+)-lactacystin.

Chemical communications (Cambridge, England) 20051028

Effect of overexpression of wild-type or mutant parkin on the cellular response induced by toxic insults.

Journal of neuroscience research 20051015

Oxidative stress augments the production of matrix metalloproteinase-1, cyclooxygenase-2, and prostaglandin E2 through enhancement of NF-kappa B activity in lipopolysaccharide-activated human primary monocytes.

Journal of immunology (Baltimore, Md. : 1950) 20051015

Expression of the ubiquitin-proteasome pathway and muscle loss in experimental cancer cachexia.

British journal of cancer 20051003

Proteasome inhibition elicits a biphasic effect on neuronal apoptosis via differential regulation of pro-survival and pro-apoptotic transcription factors.

Molecular and cellular neurosciences 20051001

Degradation of the sodium taurocholate cotransporting polypeptide (NTCP) by the ubiquitin-proteasome system.

Biological chemistry 20051001

Chemotherapy regimen GOLF induces apoptosis in colon cancer cells through multi-chaperone complex inactivation and increased Raf-1 ubiquitin-dependent degradation.

Cancer biology & therapy 20051001

Accumulation of p53 in response to adenovirus early region 1A sensitizes human cells to tumor necrosis factor alpha-induced apoptosis.

Virology 20050930

Apoptosis, necrosis and hypoxia inducible factor-1 in human head and neck squamous cell carcinoma cultures.

International journal of oncology 20050901

Cleavage of p53-vimentin complex enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of rheumatoid arthritis synovial fibroblasts.

The American journal of pathology 20050901

Identification of molecular mechanisms for cellular drug resistance by combining drug activity and gene expression profiles.

British journal of cancer 20050822

Angiotensin II directly induces muscle protein catabolism through the ubiquitin-proteasome proteolytic pathway and may play a role in cancer cachexia.

British journal of cancer 20050822

Serotonin receptor activation leads to neurite outgrowth and neuronal survival.

Brain research. Molecular brain research 20050818

Effect of statins on the proteasomal activity in mammalian endothelial and vascular smooth muscle cells.

Biochemical pharmacology 20050815

[Proteasomal inhibitor lactacystin induces cell apoptosis and caspase 3 activation in PC12 cells].

Zhonghua yi xue za zhi 20050803

Electromagnetic fields at mobile phone frequency induce apoptosis and inactivation of the multi-chaperone complex in human epidermoid cancer cells.

Journal of cellular physiology 20050801

Long-term morphine treatment enhances proteasome-dependent degradation of G beta in human neuroblastoma SH-SY5Y cells: correlation with onset of adenylate cyclase sensitization.

Molecular pharmacology 20050801

Appearance of virus-like particles in Tritrichomonas foetus after drug treatment.

Tissue & cell 20050801

Proteasome inhibition by lactacystin in primary neuronal cells induces both potentially neuroprotective and pro-apoptotic transcriptional responses: a microarray analysis.

Journal of neurochemistry 20050801

Apoptosis and the conformational change of Bax induced by proteasomal inhibition of PC12 cells are inhibited by bcl-xL and bcl-2.

Apoptosis : an international journal on programmed cell death 20050801

Neuroprotection by iron chelator against proteasome inhibitor-induced nigral degeneration.

Biochemical and biophysical research communications 20050729

Inefficient maturation of the rat luteinizing hormone receptor. A putative way to regulate receptor numbers at the cell surface.

The Journal of biological chemistry 20050715

Neuroprotection of Parkin against apoptosis is independent of inclusion body formation.

Neuroreport 20050713

Production of matrix metalloproteinase-9 by activated human monocytes involves a phosphatidylinositol-3 kinase/Akt/IKKalpha/NF-kappaB pathway.

Journal of leukocyte biology 20050701

Selective induction of the tumor marker glutathione S-transferase P1 by proteasome inhibitors.

The Journal of biological chemistry 20050701

Eukaryotic translation initiation factor 4E is a cellular target for toxicity and death due to exposure to cadmium chloride.

The Journal of biological chemistry 20050701

Electrospray ionization mass spectrometry and ion mobility analysis of the 20S proteasome complex.

Journal of the American Society for Mass Spectrometry 20050701

Rapid turnover of GATA-2 via ubiquitin-proteasome protein degradation pathway.

Genes to cells : devoted to molecular & cellular mechanisms 20050701

Calcium-activated proteases are critical for refilling depleted vesicle stores in cultured sensory-motor synapses of Aplysia.

Learning & memory (Cold Spring Harbor, N.Y.) 20050701

Brain microvessel endothelial cell responses to tumor necrosis factor-alpha involve a nuclear factor kappa B (NF-kappaB) signal transduction pathway.

Brain research 20050628

The antiepidermal growth factor receptor monoclonal antibody cetuximab/C225 reduces hypoxia-inducible factor-1 alpha, leading to transcriptional inhibition of vascular endothelial growth factor expression.

Oncogene 20050623

Epicatechin protects endothelial cells against oxidized LDL and maintains NO synthase.

Biochemical and biophysical research communications 20050617

Mouse endothelial cells cross-present lymphocyte-derived antigen on class I MHC via a TAP1- and proteasome-dependent pathway.

Journal of immunology (Baltimore, Md. : 1950) 20050615

Phosphorylation of serine 188 protects RhoA from ubiquitin/proteasome-mediated degradation in vascular smooth muscle cells.

Circulation research 20050610

Degradation of HMG-CoA reductase in rat liver is cholesterol and ubiquitin independent.

FEBS letters 20050606

Downregulation of the vasopressin type 2 receptor after vasopressin-induced internalization: involvement of a lysosomal degradation pathway.

American journal of physiology. Cell physiology 20050601

Apoptotic cells deliver processed antigen to dendritic cells for cross-presentation.

PLoS biology 20050601

Dopaminergic neurons in rat ventral midbrain cultures undergo selective apoptosis and form inclusions, but do not up-regulate iHSP70, following proteasomal inhibition.

Journal of neurochemistry 20050601

The effects of proteasome inhibitor lactacystin on mouse oocyte meiosis and first cleavage.

Science in China. Series C, Life sciences 20050601

Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage.

The Journal of biological chemistry 20050513

Degradation of trafficking-defective long QT syndrome type II mutant channels by the ubiquitin-proteasome pathway.

The Journal of biological chemistry 20050513

Shear stress inhibits smooth muscle cell-induced inflammatory gene expression in endothelial cells: role of NF-kappaB.

Arteriosclerosis, thrombosis, and vascular biology 20050501

Retrograde dopaminergic neuron degeneration following intrastriatal proteasome inhibition.

Neuroscience letters 20050501

Ascorbate depletion: a critical step in nickel carcinogenesis?

Environmental health perspectives 20050501

[Inhibiting expression of human telomerase reverse transcriptase promotes degradation of survivin protein].

Ai zheng = Aizheng = Chinese journal of cancer 20050501

P2Y6 nucleotide receptors activate NF-kappaB and increase survival of osteoclasts.

The Journal of biological chemistry 20050429

Proteasome inhibition alters glucose-stimulated (pro)insulin secretion and turnover in pancreatic {beta}-cells.

The Journal of biological chemistry 20050422

Evidence for a protective role of Mcl-1 in proteasome inhibitor-induced apoptosis.

Blood 20050415

Processing and presentation of HLA class I and II epitopes by dendritic cells after transfection with in vitro-transcribed MUC1 RNA.

Blood 20050415

Microtubule-associated protein tau is a substrate of ATP/Mg(2+)-dependent proteasome protease system.

Journal of neural transmission (Vienna, Austria : 1996) 20050401

Antitumorigenic effect of proteasome inhibitors on insulinoma cells.

Endocrinology 20050401

Peroxisome proliferator-activated receptor gamma-independent ablation of cyclin D1 by thiazolidinediones and their derivatives in breast cancer cells.

Molecular pharmacology 20050401

Interferon-beta-induced activation of c-Jun NH2-terminal kinase mediates apoptosis through up-regulation of CD95 in CH31 B lymphoma cells.

Experimental cell research 20050401

Gamma-herpesvirus latency requires T cell evasion during episome maintenance.

PLoS biology 20050401

Impairment of the ubiquitin-proteasome system by truncated cardiac myosin binding protein C mutants.

Cardiovascular research 20050401

GLUT4 expression in 3T3-L1 adipocytes is repressed by proteasome inhibition, but not by inhibition of calpains.

Molecular and cellular endocrinology 20050331

Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII.

The Journal of biological chemistry 20050325

Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells.

The Journal of biological chemistry 20050325

Effects of DJ-1 mutations and polymorphisms on protein stability and subcellular localization.

Brain research. Molecular brain research 20050324

Cbl-mediated ubiquitination of alpha5 integrin subunit mediates fibronectin-dependent osteoblast detachment and apoptosis induced by FGFR2 activation.

Journal of cell science 20050315

Regulation of serum response factor-dependent gene expression by proteasome inhibitors.

Molecular pharmacology 20050301

Characterization of signaling pathways leading to Fas expression induced by TNF-alpha: pivotal role of NF-kappaB.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050301

Glucosamine-induced endoplasmic reticulum stress promotes ApoB100 degradation: evidence for Grp78-mediated targeting to proteasomal degradation.

Arteriosclerosis, thrombosis, and vascular biology 20050301

Growth-associated protein-43 is degraded via the ubiquitin-proteasome system.

Journal of neuroscience research 20050301

Trypanosoma cruzi histone H1 is phosphorylated in a typical cyclin dependent kinase site accordingly to the cell cycle.

Molecular and biochemical parasitology 20050301

Effects of exogenous ubiquitin on cell division cycle mutants of Schizosaccharomyces pombe.

FEMS microbiology letters 20050301

Does proteasome [corrected] inhibition decrease or accelerate toxin-induced dopaminergic neurodegeneration?

Journal of pharmacological sciences 20050301

Nutritional regulation of proteases involved in fetal rat insulin secretion and islet cell proliferation.

The British journal of nutrition 20050301

NF-kappaB mediates proteolysis-inducing factor induced protein degradation and expression of the ubiquitin-proteasome system in skeletal muscle.

British journal of cancer 20050227

Filamin A binding stabilizes nascent glycoprotein Ibalpha trafficking and thereby enhances its surface expression.

The Journal of biological chemistry 20050225

Upregulation of clusterin/apolipoprotein J in lactacystin-treated SH-SY5Y cells.

Journal of neuroscience research 20050215

Oxidized linoleic acid regulates expression and shedding of syndecan-4.

American journal of physiology. Cell physiology 20050201

Role of Bcl-xL in paracetamol-induced tubular epithelial cell death.

Kidney international 20050201

Proteasome inhibitors protect against degeneration of nigral dopaminergic neurons in hemiparkinsonian rats.

Journal of pharmacological sciences 20050201

Proteasome inhibition protects HT22 neuronal cells from oxidative glutamate toxicity.

Journal of neurochemistry 20050201

Proteasome or calpain inhibition does not alter cellular tau levels in neuroblastoma cells or primary neurons.

Journal of Alzheimer's disease : JAD 20050201

Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells.

The Journal of biological chemistry 20050121

Proteasome-mediated effects on amyloid precursor protein processing at the gamma-secretase site.

The Biochemical journal 20050115

Axonal protein synthesis and degradation are necessary for efficient growth cone regeneration.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20050112

Cellular ubiquitination and proteasomal functions positively modulate mammalian nucleotide excision repair.

Molecular carcinogenesis 20050101

Alpha B-crystallin is a major component of glial cytoplasmic inclusions in multiple system atrophy.

Neurotoxicity research 20050101

Kaposi's sarcoma associated herpes virus-encoded viral FLICE inhibitory protein activates transcription from HIV-1 Long Terminal Repeat via the classical NF-kappaB pathway and functionally cooperates with Tat.

Retrovirology 20050101

The proteasome: a central regulator of inflammation and macrophage function.

Immunologic research 20050101

Shear stress regulates gene expression in vascular endothelial cells in response to tumor necrosis factor-alpha: a study of the transcription profile with complementary DNA microarray.

Journal of biomedical science 20050101

The proteasome inhibitor MG-132 sensitizes PC-3 prostate cancer cells to ionizing radiation by a DNA-PK-independent mechanism.

BMC cancer 20050101

In vitro and in vivo assays for osteoclast apoptosis.

Biological procedures online 20050101

Anthracyclines, proteasome activity and multi-drug-resistance.

BMC cancer 20050101

Cell-specific inhibition of paramyxovirus maturation by proteasome inhibitors.

Microbiology and immunology 20050101

Constitutive degradation of IkappaBalpha in human T lymphocytes is mediated by calpain.

Immunity & ageing : I & A 20050101

Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase.

The Journal of biological chemistry 20041217

The met receptor degradation pathway: requirement for Lys48-linked polyubiquitin independent of proteasome activity.

The Journal of biological chemistry 20041217

Retinoic acid mediates degradation of IRS-1 by the ubiquitin-proteasome pathway, via a PKC-dependant mechanism.

Oncogene 20041209

A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs.

The Biochemical journal 20041201

7-ketocholesterol induces protein ubiquitination, myelin figure formation, and light chain 3 processing in vascular smooth muscle cells.

Arteriosclerosis, thrombosis, and vascular biology 20041201

Human CD8+ T cells recognize the 60-kDa cysteine-rich outer membrane protein from Chlamydia trachomatis.

Journal of immunology (Baltimore, Md. : 1950) 20041201

Proteasome inhibitors suppress formation of polyglutamine-induced nuclear inclusions in cultured postmitotic neurons.

Journal of neurochemistry 20041201

Loss of syk kinase during IgE-mediated stimulation of human basophils.

The Journal of allergy and clinical immunology 20041201

BACE1 gene expression and protein degradation.

Annals of the New York Academy of Sciences 20041201

Inhibitors of the eukaryotic 20S proteasome core particle: a structural approach.

Biochimica et biophysica acta 20041129

cAMP-dependent protein kinase regulates ubiquitin-proteasome-mediated degradation and subcellular localization of the nuclear receptor coactivator GRIP1.

The Journal of biological chemistry 20041119

A novel gene family induced by acute inflammation in endothelial cells.

Gene 20041110

alpha-synuclein is required for the fibrillar nature of ubiquitinated inclusions induced by proteasomal inhibition in primary neurons.

The Journal of biological chemistry 20041105

Resistance of the human beta1-adrenergic receptor to agonist-induced ubiquitination: a mechanism for impaired receptor degradation.

The Journal of biological chemistry 20041105

Coordination of oxidized protein hydrolase and the proteasome in the clearance of cytotoxic denatured proteins.

Biochemical and biophysical research communications 20041105

Proteasomal interference prevents zona pellucida penetration and fertilization in mammals.

Biology of reproduction 20041101

Protective effect of TAT-delivered alpha-synuclein: relevance of the C-terminal domain and involvement of HSP70.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20041101

Induction of proteasome expression in skeletal muscle is attenuated by inhibitors of NF-kappaB activation.

British journal of cancer 20041101

Proteasomes act in the pre-mitochondrial signal transduction route towards roscovitine-induced apoptosis.

International journal of oncology 20041101

Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism.

PLoS biology 20041101

DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation.

PLoS biology 20041101

Probiotics inhibit nuclear factor-kappaB and induce heat shock proteins in colonic epithelial cells through proteasome inhibition.

Gastroenterology 20041101

Effect of proteasome pathway on initiation of mouse labor induced by antiprogesterone.

American journal of reproductive immunology (New York, N.Y. : 1989) 20041101

A concise route to (+)-lactacystin.

The Journal of organic chemistry 20041029

Regulation of nicotinic receptor expression by the ubiquitin-proteasome system.

The EMBO journal 20041027

Acute exercise alters Galphai2 protein expressions through the ubiquitin-proteasome proteolysis pathway in rat adipocytes.

Biochemical and biophysical research communications 20041022

Degradation of BACE by the ubiquitin-proteasome pathway.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20041001

Identification of the protein disulfide isomerase family member PDIp in experimental Parkinson's disease and Lewy body pathology.

Brain research 20041001

MKP-1 expression and stabilization and cGK Ialpha prevent diabetes- associated abnormalities in VSMC migration.

American journal of physiology. Cell physiology 20041001

Inhibition of proteasome activity sensitizes dopamine neurons to protein alterations and oxidative stress.

Journal of neural transmission (Vienna, Austria : 1996) 20041001

[BAY11-7082 and Lactacystein in CD154-induced NF-kappaB activation].

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20041001

Proteasome-dependent degradation of cytochromes P450 2E1 and 2B1 expressed in tetracycline-regulated HeLa cells.

Toxicology and applied pharmacology 20040915

Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals.

Journal of immunology (Baltimore, Md. : 1950) 20040901

Application of proteasomal inhibitors to mouse sympathetic neurons activates the intrinsic apoptotic pathway.

Journal of neurochemistry 20040901

Mesangial cell Fas ligand: upregulation in human lupus nephritis and NF-kappaB-mediated expression in cultured human mesangial cells.

Clinical and experimental nephrology 20040901

p38 MAPK mediates TNF-induced apoptosis in endothelial cells via phosphorylation and downregulation of Bcl-x(L).

Experimental cell research 20040815

Lactacystin-induced apoptosis of cultured mouse cortical neurons is associated with accumulation of PTEN in the detergent-resistant membrane fraction.

Cellular and molecular life sciences : CMLS 20040801

Nestin expression is lost in a neural stem cell line through a mechanism involving the proteasome and Notch signalling.

Brain research. Developmental brain research 20040719

Decreased E47 in senescent B cell precursors is stage specific and regulated posttranslationally by protein turnover.

Journal of immunology (Baltimore, Md. : 1950) 20040715

The Leishmania chagasi proteasome: role in promastigotes growth and amastigotes survival within murine macrophages.

Acta tropica 20040701

High glucose down-regulates intercellular communication in retinal endothelial cells by enhancing degradation of connexin 43 by a proteasome-dependent mechanism.

The Journal of biological chemistry 20040625

Proteolytic stress causes heat shock protein induction, tau ubiquitination, and the recruitment of ubiquitin to tau-positive aggregates in oligodendrocytes in culture.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20040623

Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C.

The Journal of biological chemistry 20040611

Transcriptional repression of E2F gene by proteasome inhibitors in human osteosarcoma cells.

Biochemical and biophysical research communications 20040611

Degradation of the LDL receptor class 2 mutants is mediated by a proteasome-dependent pathway.

Journal of lipid research 20040601

Protein kinase A activation of estrogen receptor alpha transcription does not require proteasome activity and protects the receptor from ligand-mediated degradation.

Endocrinology 20040601

Efficient scavenger receptor-mediated uptake and cross-presentation of negatively charged soluble antigens by dendritic cells.

Immunology 20040601

Distinct effects of the antiestrogen Faslodex on the stability of estrogen receptors-alpha and -beta in the breast cancer cell line MCF-7.

Journal of molecular endocrinology 20040601

Endolysosomal processing of exogenous antigen into major histocompatibility complex class I-binding peptides.

Scandinavian journal of immunology 20040601

Alpha-actinin-4-mediated FSGS: an inherited kidney disease caused by an aggregated and rapidly degraded cytoskeletal protein.

PLoS biology 20040601

CD8+ T cell cross-priming via transfer of proteasome substrates.

Science (New York, N.Y.) 20040528

Role of protein kinase C and NF-kappaB in proteolysis-inducing factor-induced proteasome expression in C(2)C(12) myotubes.

British journal of cancer 20040504

Proteasome-mediated degradation of cell division cycle 25C and cyclin-dependent kinase 1 in phenethyl isothiocyanate-induced G2-M-phase cell cycle arrest in PC-3 human prostate cancer cells.

Molecular cancer therapeutics 20040501

Microbial serine carboxypeptidase inhibitors--comparative analysis of actions on homologous enzymes derived from man, yeast and wheat.

The Journal of antibiotics 20040501

An efficient synthesis of lactacystin beta-lactone.

Angewandte Chemie (International ed. in English) 20040419

Role of the NH2 terminus in the assembly and trafficking of the intermediate conductance Ca2+-activated K+ channel hIK1.

The Journal of biological chemistry 20040409

AP-1-independent sensitization to oxidative stress-induced apoptosis by proteasome inhibitors.

Biochemical and biophysical research communications 20040402

Influence of p53 and p21Waf1 expression on G2/M phase arrest of colorectal carcinoma HCT116 cells to proteasome inhibitors.

International journal of oncology 20040401

Inducible superoxide dismutase 1 aggregation in transgenic amyotrophic lateral sclerosis mouse fibroblasts.

Journal of cellular biochemistry 20040401

Alternative processing for MHC class I presentation by immature and CpG-activated dendritic cells.

European journal of immunology 20040401

Effect of ajoene, a natural antitumor small molecule, on human 20S proteasome activity in vitro and in human leukemic HL60 cells.

Fundamental & clinical pharmacology 20040401

Trastuzumab (Herceptin) enhances class I-restricted antigen presentation recognized by HER-2/neu-specific T cytotoxic lymphocytes.

Clinical cancer research : an official journal of the American Association for Cancer Research 20040401

Phthalocyanine tetrasulfonates affect the amyloid formation and cytotoxicity of alpha-synuclein.

Biochemistry 20040330

The islet-specific glucose-6-phosphatase-related protein, implicated in diabetes, is a glycoprotein embedded in the endoplasmic reticulum membrane.

FEBS letters 20040326

GSK3 beta-dependent phosphorylation of the alpha NAC coactivator regulates its nuclear translocation and proteasome-mediated degradation.

Biochemistry 20040316

Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions.

The Journal of biological chemistry 20040312

Degradation properties of polyglutamine-expanded human androgen receptor in transfected cells.

Neuroscience letters 20040311

DJ-1 mutations are a rare cause of recessively inherited early onset parkinsonism mediated by loss of protein function.

Journal of medical genetics 20040301

Effect of apolipoprotein A-I on ATP binding cassette transporter A1 degradation and cholesterol efflux in THP-1 macrophage-derived foam cells.

Acta biochimica et biophysica Sinica 20040301

Long term proteasome inhibition does not preferentially afflict motor neurons in organotypical spinal cord cultures.

Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 20040301

Purification of the Arabidopsis 26 S proteasome: biochemical and molecular analyses revealed the presence of multiple isoforms.

The Journal of biological chemistry 20040220

Molecular mechanisms regulating protein kinase Czeta turnover and cellular transformation.

The Biochemical journal 20040215

Herceptin-geldanamycin immunoconjugates: pharmacokinetics, biodistribution, and enhanced antitumor activity.

Cancer research 20040215

Mammalian D-aspartyl endopeptidase: a scavenger for noxious racemized proteins in aging.

Biochemical and biophysical research communications 20040213

Sensitivity of proteasome to its inhibitors increases during cAMP-induced differentiation of neuroblastoma cells in culture and causes decreased viability.

Cancer letters 20040210

Effect of ubiquitin-proteasome pathway on mouse blastocyst implantation and expression of matrix metalloproteinases-2 and -9.

Biology of reproduction 20040201

Proteasome inhibitors induce inhibitory kappa B (I kappa B) kinase activation, I kappa B alpha degradation, and nuclear factor kappa B activation in HT-29 cells.

Molecular pharmacology 20040201

Biochemical properties of the P42 protein encoded by RNA segment 6 of influenza C virus.

Archives of virology 20040201

The inhibitory role of lactacystin and beta-lactacystin on T-cell activation and proliferation.

Acta biochimica et biophysica Sinica 20040201

Implications of proteasome inhibition: an enhanced macrophage phenotype.

Cellular immunology 20040201

[Effect of ubiquitin-proteasome pathway on TRAIL inducing apoptosis].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20040201

Epidermal growth factor receptor activation differentially regulates claudin expression and enhances transepithelial resistance in Madin-Darby canine kidney cells.

The Journal of biological chemistry 20040130

A new structural class of proteasome inhibitors identified by microbial screening using yeast-based assay.

Biochemical pharmacology 20040115

Both insulin resistance and diabetes in Psammomys obesus upregulate the hepatic machinery involved in intracellular VLDL assembly.

Arteriosclerosis, thrombosis, and vascular biology 20040101

Interferon-gamma induces apoptosis of lens alphaTN4-1 cells and proteasome inhibition has an antiapoptotic effect.

Investigative ophthalmology & visual science 20040101

A novel gene mutation in the 60s loop of human coagulation factor VII - inhibition of interdomain crosstalk.

Thrombosis and haemostasis 20040101

Examination of the mechanism(s) involved in doxorubicin-mediated iron accumulation in ferritin: studies using metabolic inhibitors, protein synthesis inhibitors, and lysosomotropic agents.

Molecular pharmacology 20040101

Degradation of pro-insulin-receptor proteins by proteasomes.

Archives of medical research 20040101

Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro.

Breast cancer research : BCR 20040101

Heparin cofactor II is more sensitive than antithrombin to secretory impairment arising from mutations introduced into its carboxy-terminal region.

Thrombosis research 20040101

The Icelandic founder mutation BRCA2 999del5: analysis of expression.

Breast cancer research : BCR 20040101

Post-translational generation of constitutively active cores from larger phosphatases in the malaria parasite, Plasmodium falciparum: implications for proteomics.

BMC molecular biology 20040101

Proteasome inhibitors: their effects on arachidonic acid release from cells in culture and arachidonic acid metabolism in rat liver cells.

BMC pharmacology 20040101

Tamoxifen and the Rafoxifene analog LY117018: their effects on arachidonic acid release from cells in culture and on prostaglandin I2 production by rat liver cells.

BMC cancer 20040101

Oxidative stress, induced by 6-hydroxydopamine, reduces proteasome activities in PC12 cells: implications for the pathogenesis of Parkinson's disease.

Journal of molecular neuroscience : MN 20040101

Lipopolysaccharide negatively modulates vitamin D action by down-regulating expression of vitamin D-induced VDR in human monocytic THP-1 cells.

Cellular immunology 20040101

Proteasome inhibition arrests neurite outgrowth and causes 'dying-back' degeneration in primary culture.

Journal of neuroscience research 20031215

The effects of post-translational processing on dystroglycan synthesis and trafficking.

FEBS letters 20031204

The ubiquitin-vacuolar protein sorting system is selectively required during entry of influenza virus into host cells.

Traffic (Copenhagen, Denmark) 20031201

MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation.

The EMBO journal 20031201

Retrograde transport of toxins across the endoplasmic reticulum membrane.

Biochemical Society transactions 20031201

Circadian rhythm and photic control of cAMP level in chick retinal cell cultures: a mechanism for coupling the circadian oscillator to the melatonin-synthesizing enzyme, arylalkylamine N-acetyltransferase, in photoreceptor cells.

Brain research 20031121

The mechanism of alphaB-crystallin gene expression by proteasome inhibition.

Biochemical and biophysical research communications 20031107

Effect of MG132, a proteasome inhibitor, on the expression of growth related oncogene protein-alpha in human umbilical vein endothelial cells.

Cytokine 20031107

Proteolysis of type I inositol 1,4,5-trisphosphate receptor in WB rat liver cells.

The Biochemical journal 20031101

Inhibition of proteasome function leads to NF-kappaB-independent IL-8 expression in human hepatocytes.

Hepatology (Baltimore, Md.) 20031101

Insulin inhibition of protein degradation in cells expressing wild-type and mutant insulin receptors.

Journal of endocrinological investigation 20031101

Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression.

Neuron 20031030

Cell cycle- and activation-dependent regulation of cyclosporin A-induced T cell apoptosis.

Biochemical and biophysical research communications 20031017

Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPK/JNK- and NF-kappaB-dependent process.

Oncogene 20031016

Involvement of the ubiquitin-proteasome pathway and molecular chaperones in oculopharyngeal muscular dystrophy.

Human molecular genetics 20031015

Adenovirus E4-34kDa requires active proteasomes to promote late gene expression.

Virology 20031010

The ubiquitin-like domain of Herp is involved in Herp degradation, but not necessary for its enhancement of amyloid beta-protein generation.

FEBS letters 20031009

A proteasome inhibitor reduces concurrent, sequential, and long-term IL-1 beta- and TNF-alpha-induced ECAM expression and adhesion.

American journal of physiology. Cell physiology 20031001

Parkin is recruited to the centrosome in response to inhibition of proteasomes.

Journal of cell science 20031001

Fine structure and biochemical mechanisms underlying nigrostriatal inclusions and cell death after proteasome inhibition.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20031001

Increased expression of the ubiquitin-proteasome pathway in murine myotubes by proteolysis-inducing factor (PIF) is associated with activation of the transcription factor NF-kappaB.

British journal of cancer 20030915

Ligand-induced lysosomal epidermal growth factor receptor (EGFR) degradation is preceded by proteasome-dependent EGFR de-ubiquitination.

The Journal of biological chemistry 20030912

Copper modulates the degradation of copper chaperone for Cu,Zn superoxide dismutase by the 26 S proteosome.

The Journal of biological chemistry 20030912

Requirement of the proteasome for the trimming of signal peptide-derived epitopes presented by the nonclassical major histocompatibility complex class I molecule HLA-E.

The Journal of biological chemistry 20030905

Proteasome is required for class I-restricted presentation by Fcgamma receptor-mediated endocytosis in primary biliary cirrhosis.

Journal of autoimmunity 20030901

Induction of protein catabolism in myotubes by 15(S)-hydroxyeicosatetraenoic acid through increased expression of the ubiquitin-proteasome pathway.

British journal of cancer 20030818

Lysosomal and proteasomal degradation play distinct roles in the life cycle of Cx43 in gap junctional intercellular communication-deficient and -competent breast tumor cells.

The Journal of biological chemistry 20030808

CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins.

The Journal of biological chemistry 20030801

Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels.

The Journal of biological chemistry 20030801

Induction of apoptosis in human osteosarcoma Saos-2 cells by the proteasome inhibitor MG132 and the protective effect of pRb.

Cell death and differentiation 20030801

Preservation of caspase-3 subunits from degradation contributes to apoptosis evoked by lactacystin: any single lysine or lysine pair of the small subunit is sufficient for ubiquitination.

Molecular pharmacology 20030801

The proteasome as a lipopolysaccharide-binding protein in macrophages: differential effects of proteasome inhibition on lipopolysaccharide-induced signaling events.

Journal of immunology (Baltimore, Md. : 1950) 20030801

Proteasome inhibition reduces coxsackievirus B3 replication in murine cardiomyocytes.

The American journal of pathology 20030801

Oxidative-stress-induced T lymphocyte hyporesponsiveness is caused by structural modification rather than proteasomal degradation of crucial TCR signaling molecules.

European journal of immunology 20030801

Evidence for proteasome dysfunction in cytotoxicity mediated by anti-Ras intracellular antibodies.

European journal of biochemistry 20030801

Shiga toxin induces decreased expression of the anti-apoptotic protein Mcl-1 concomitant with the onset of endothelial apoptosis.

Microbial pathogenesis 20030801

Proteomic analysis of ubiquitin-proteasome effects: insight into the function of eukaryotic initiation factor 5A.

Oncogene 20030731

The intracellular domain of teneurin-2 has a nuclear function and represses zic-1-mediated transcription.

Journal of cell science 20030715

Enhancement of endoplasmic reticulum (ER) degradation of misfolded Null Hong Kong alpha1-antitrypsin by human ER mannosidase I.

The Journal of biological chemistry 20030711

Function and stability of human transcobalamin II: role of intramolecular disulfide bonds C98-C291 and C147-C187.

American journal of physiology. Cell physiology 20030701

Troglitazone reduces heat shock protein 70 content in primary rat hepatocytes by a ubiquitin proteasome independent mechanism.

Pharmacological research 20030701

Dendritic cell maturation enhances CD8+ T-cell responses to exogenous antigen via a proteasome-independent mechanism of major histocompatibility complex class I loading.

Immunology 20030701

Imaging 26S proteasome activity and inhibition in living mice.

Nature medicine 20030701

Inhibition of the proteasome induces cell cycle arrest and apoptosis in mantle cell lymphoma cells.

British journal of haematology 20030701

Proteasome inhibitors induce growth inhibition and apoptosis in myeloma cell lines and in human bone marrow myeloma cells irrespective of chromosome 13 deletion.

Journal of cancer research and clinical oncology 20030701

Proteasomal inhibition causes the formation of protein aggregates containing a wide range of proteins, including nitrated proteins.

Journal of neurochemistry 20030701

Cold-induced apoptosis of rat liver endothelial cells: involvement of the proteasome.

Transplantation 20030627

Suppression of cytochrome P450 3A protein levels by proteasome inhibitors.

The Journal of pharmacology and experimental therapeutics 20030601

Proteasome activation and nNOS down-regulation in neuroblastoma cells expressing a Cu,Zn superoxide dismutase mutant involved in familial ALS.

Journal of neurochemistry 20030601

Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease.

Human molecular genetics 20030601

Lactacystin augments the sulindac-induced apoptosis in HT-29 cells.

Apoptosis : an international journal on programmed cell death 20030601

Inhibition of the proteasome by lactacystin enhances oligodendroglial cell differentiation.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20030601

Myogenic differentiation of Drosophila Schneider cells by DNA double-strand break-inducing drugs.

Differentiation; research in biological diversity 20030601

Lithium stabilizes the CCAAT/enhancer-binding protein alpha (C/EBPalpha) through a glycogen synthase kinase 3 (GSK3)-independent pathway involving direct inhibition of proteasomal activity.

The Journal of biological chemistry 20030530

Tumor necrosis factor-alpha-induced targeted proteolysis of cystathionine beta-synthase modulates redox homeostasis.

The Journal of biological chemistry 20030509

Proteasome inhibitors induce intracellular protein aggregation and cell death by an oxygen-dependent mechanism.

FEBS letters 20030508

Quantity and quality control of gastric proton pump in the endoplasmic reticulum by ubiquitin/proteasome system.

Biochemistry 20030506

Targeted degradation of ENaC in response to PKC activation of the ERK1/2 cascade.

American journal of physiology. Renal physiology 20030501

Early degradation of paternal mitochondria in domestic pig (Sus scrofa) is prevented by selective proteasomal inhibitors lactacystin and MG132.

Biology of reproduction 20030501

Early mitochondrial hyperpolarization and intracellular alkalinization in lactacystin-induced apoptosis of retinal pigment epithelial cells.

The Journal of pharmacology and experimental therapeutics 20030501

Assessment of proteasome activity in cell lysates and tissue homogenates using peptide substrates.

The international journal of biochemistry & cell biology 20030501

Differential regulation of proteasome-dependent estrogen receptor alpha and beta turnover in cultured human uterine artery endothelial cells.

The Journal of clinical endocrinology and metabolism 20030501

Conformational change and mitochondrial translocation of Bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells.

Oncogene 20030501

IRS1 degradation and increased serine phosphorylation cannot predict the degree of metabolic insulin resistance induced by oxidative stress.

Diabetologia 20030501

Human platelet 20S proteasome: inhibition of its chymotrypsin-like activity and identification of the proteasome activator PA28. A preliminary report.

Platelets 20030501

SKP2 associates with p130 and accelerates p130 ubiquitylation and degradation in human cells.

Oncogene 20030424

p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells.

Oncogene 20030417

Calpain is involved in the HIV replication from the latently infected OM10.1 cells.

Biochemical and biophysical research communications 20030411

Sumoylation of Pdx1 is associated with its nuclear localization and insulin gene activation.

American journal of physiology. Endocrinology and metabolism 20030401

Mitogen-activated protein kinase regulates nuclear association of human progesterone receptors.

Molecular endocrinology (Baltimore, Md.) 20030401

Relationship between beta-amyloid degradation and the 26S proteasome in neural cells.

Experimental neurology 20030401

Inhibition of ubiquitin ligase Siah-1A by disabled-1.

Biochemical and biophysical research communications 20030321

NF-kappa B is required for surface Ig-induced Fas resistance in B cells.

Journal of immunology (Baltimore, Md. : 1950) 20030315

The human herpes virus 8-encoded viral FLICE inhibitory protein protects against growth factor withdrawal-induced apoptosis via NF-kappa B activation.

Blood 20030301

Synthetic chenodeoxycholic acid derivative HS-1200-induced apoptosis of p815 mastocytoma cells is augmented by co-treatment with lactacystin.

Anti-cancer drugs 20030301

Cycling B-CLL cells are highly susceptible to inhibition of the proteasome: involvement of p27, early D-type cyclins, Bax, and caspase-dependent and -independent pathways.

Experimental hematology 20030301

Regulation of sympathetic neuron and neuroblastoma cell death by XIAP and its association with proteasomes in neural cells.

Molecular and cellular neurosciences 20030301

EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin.

Science (New York, N.Y.) 20030227

Nuclear export inhibitor leptomycin B induces the appearance of novel forms of human Mdm2 protein.

British journal of cancer 20030224

Ubiquitination of tissue transglutaminase is modulated by interferon alpha in human lung cancer cells.

The Biochemical journal 20030215

Synaptic Drosophila UNC-13 is regulated by antagonistic G-protein pathways via a proteasome-dependent degradation mechanism.

Journal of neurobiology 20030215

Cyclin-dependent kinase activity is required for apoptotic death but not inclusion formation in cortical neurons after proteasomal inhibition.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20030215

Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome.

The Journal of biological chemistry 20030214

Inhibition of hepatitis B virus replication by drug-induced depletion of nucleocapsids.

Science (New York, N.Y.) 20030207

Short and versatile route to a key intermediate for lactacystin synthesis.

Organic letters 20030206

C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradation.

Archives of biochemistry and biophysics 20030201

Fusion with HDEL protects cell wall invertase from early degradation when N-glycosylation is inhibited.

Plant & cell physiology 20030201

[Synthetic studies of microbial natural products from microorganisms].

The Japanese journal of antibiotics 20030201

Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium.

The Journal of biological chemistry 20030124

NF-kappaB inhibition impairs the radioresponse of hypoxic EMT-6 tumour cells through downregulation of inducible nitric oxide synthase.

British journal of cancer 20030113

Heterodimerization of endothelin-converting enzyme-1 isoforms regulates the subcellular distribution of this metalloprotease.

The Journal of biological chemistry 20030103

Multiple forms of estrogen receptor-alpha in cerebral blood vessels: regulation by estrogen.

American journal of physiology. Endocrinology and metabolism 20030101

A major role for tapasin as a stabilizer of the TAP peptide transporter and consequences for MHC class I expression.

European journal of immunology 20030101

Statins stimulate arachidonic acid release and prostaglandin I2 production in rat liver cells.

Lipids in health and disease 20030101

Tamoxifen stimulates arachidonic acid release from rat liver cells by an estrogen receptor-independent, non-genomic mechanism.

BMC cancer 20030101

Ubiquitinylation and proteasome-dependent degradation of the phosphoinositide-specific phospholipase C gamma 1 in A-431 cells.

Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20030101

Differential apoptotic response to the proteasome inhibitor Bortezomib [VELCADE, PS-341] in Bax-deficient and p21-deficient colon cancer cells.

Cancer biology & therapy 20030101

[Effect of EGF on ubiquitination and proteasome-dependent degradation of phospholipase C gamma1 in A431 cells].

Tsitologiia 20030101

Ubiquitination-independent trafficking of G protein-coupled receptors to lysosomes.

The Journal of biological chemistry 20021227

Nitric oxide induces neutral ceramidase degradation by the ubiquitin/proteasome complex in renal mesangial cell cultures.

FEBS letters 20021218

Mutations at the P1' position of Notch1 decrease intracellular domain stability rather than cleavage by gamma-secretase.

Biochemical and biophysical research communications 20021213

Nuclear phosphatases and the proteasome in suppression of STAT1 activity in hepatocytes.

Biochemical and biophysical research communications 20021213

Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation.

Oncogene 20021212

Cleavage of p21waf1 by proteinase-3, a myeloid-specific serine protease, potentiates cell proliferation.

The Journal of biological chemistry 20021206

Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis.

Journal of neurochemistry 20021201

Structure-function analysis of the glucose-6-phosphate transporter deficient in glycogen storage disease type Ib.

Human molecular genetics 20021201

Aggresome-related biogenesis of Lewy bodies.

The European journal of neuroscience 20021201

c-Jun N-terminal kinase pathway mediates Lactacystin-induced cell death in a neuronal differentiated Neuro2a cell line.

Brain research. Molecular brain research 20021201

Stimulation of melanoblast pigmentation by 8-methoxypsoralen:the involvement of microphthalmia-associated transcription factor, the protein kinase a signal pathway, and proteasome-mediated degradation.

The Journal of investigative dermatology 20021201

CXCR4 heterogeneity in primary cells: possible role of ubiquitination.

Journal of leukocyte biology 20021201

Nitric oxide induces degradation of the neutral ceramidase in rat renal mesangial cells and is counterregulated by protein kinase C.

The Journal of biological chemistry 20021129

Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol.

Science (New York, N.Y.) 20021129

ABCA1-mediated cholesterol efflux is defective in free cholesterol-loaded macrophages. Mechanism involves enhanced ABCA1 degradation in a process requiring full NPC1 activity.

The Journal of biological chemistry 20021108

Proteinases of Trypanosoma cruzi: patential targets for the chemotherapy of Changas desease.

Current topics in medicinal chemistry 20021101

Interleukin-3, but not granulocyte-macrophage colony-stimulating factor and interleukin-5, inhibits apoptosis of human basophils through phosphatidylinositol 3-kinase: requirement of NF-kappaB-dependent and -independent pathways.

Immunology 20021101

Sustained activation of N-WASP through phosphorylation is essential for neurite extension.

Developmental cell 20021101

Cytosolic and nuclear aggregation of the amyloid beta-peptide following its expression in the endoplasmic reticulum.

Histochemistry and cell biology 20021101

Effects of proteasome inhibitor (lactacystin) and cysteine protease inhibitor (E-64-d) on processes of mitosis in Xenopus embryonic cells.

Zoological science 20021101

Apoptosis in Schwann cell cultures is closely interrelated with the activity of the ubiquitin-proteasome proteolytic pathway.

Neurochemical research 20021101

The life cycle of the steroidogenic acute regulatory (StAR) protein: from transcription through proteolysis.

Endocrine research 20021101

Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop.

Science (New York, N.Y.) 20021025

Proteasome inhibitors reconstitute the presentation of cytotoxic T-cell epitopes in Epstein-Barr virus-associated tumors.

International journal of cancer 20021020

The final N-terminal trimming of a subaminoterminal proline-containing HLA class I-restricted antigenic peptide in the cytosol is mediated by two peptidases.

Journal of immunology (Baltimore, Md. : 1950) 20021015

Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (cdk5), on the proteolysis of p35.

Brain research. Molecular brain research 20021015

Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) up-regulates death receptor 5 (DR5) mediated by NFkappaB activation in epithelial derived cell lines.

Apoptosis : an international journal on programmed cell death 20021001

Ligand-dependent and independent modulation of aryl hydrocarbon receptor localization, degradation, and gene regulation.

Molecular pharmacology 20021001

Proteasomal degradation of tau protein.

Journal of neurochemistry 20021001

Ezrin turnover and cell shape changes catalyzed by proteasome in oxidatively stressed cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021001

Cross-presentation of cell-associated antigens by CD8alpha+ dendritic cells is attributable to their ability to internalize dead cells.

Immunology 20021001

Subcellular recruitment of fibrillarin to nucleoplasmic proteasomes: implications for processing of a nucleolar autoantigen.

Molecular biology of the cell 20021001

Synphilin-1 degradation by the ubiquitin-proteasome pathway and effects on cell survival.

Journal of neurochemistry 20021001

Accelerated degradation of mislocalized UDP-glucuronosyltransferase family 1 (UGT1) proteins in Gunn rat hepatocytes.

Archives of biochemistry and biophysics 20020915

Proteasome inhibitors regulate tyrosine phosphorylation of IRS-1 and insulin signaling in adipocytes.

Biochemical and biophysical research communications 20020906

Anticancer-drug-induced apoptotic cell death in leukemia cells is associated with proteolysis of beta-catenin.

Leukemia research 20020901

Glucocorticoid-mediated attenuation of the hsp70 response in trout hepatocytes involves the proteasome.

American journal of physiology. Regulatory, integrative and comparative physiology 20020901

The effects of lovastatin on proteasome activities in highly purified rabbit 20 S proteasome preparations and mouse MC3T3-E1 osteoblastic cells.

Metabolism: clinical and experimental 20020901

Proteasome inhibitors induce apoptosis in growth hormone- and prolactin-secreting rat pituitary tumor cells.

The Journal of endocrinology 20020901

Proteasome-dependent regulation of Syk tyrosine kinase levels in human basophils.

The Journal of allergy and clinical immunology 20020901

Aberrant apoptosis in thyroid epithelial cells from goiter nodules.

The Journal of clinical endocrinology and metabolism 20020901

Inhibition of hepatocyte apoB secretion by naringenin: enhanced rapid intracellular degradation independent of reduced microsomal cholesteryl esters.

Journal of lipid research 20020901

Proteasome-dependent downregulation of p21(Waf1/Cip1) induced by reactive oxygen species.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20020901

The DNA repair protein, O(6)-methylguanine-DNA methyltransferase is a proteolytic target for the E6 human papillomavirus oncoprotein.

Oncogene 20020829

Proteasome inhibitors stimulate activator protein-1 pathway via reactive oxygen species production.

FEBS letters 20020828

Induction and superinduction of 2,3,7,8-tetrachlorodibenzo-rho-dioxin-inducible poly(ADP-ribose) polymerase: role of the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator transcription activation domains and a labile transcription repressor.

Archives of biochemistry and biophysics 20020815

Effect of wild-type or mutant Parkin on oxidative damage, nitric oxide, antioxidant defenses, and the proteasome.

The Journal of biological chemistry 20020809

Proteasome inhibition causes nigral degeneration with inclusion bodies in rats.

Neuroreport 20020807

The inhibition of microsomal triglyceride transfer protein activity in rat hepatoma cells promotes proteasomal and nonproteasomal degradation of apoprotein b100.

Biochemistry 20020806

Evidence that inhibition of p44/42 mitogen-activated protein kinase signaling is a factor in proteasome inhibitor-mediated apoptosis.

The Journal of biological chemistry 20020802

Effect of geranylgeranylaceton on cellular damage induced by proteasome inhibition in cultured spinal neurons.

Journal of neuroscience research 20020801

Proteasome inhibitors stimulate interleukin-8 expression via Ras and apoptosis signal-regulating kinase-dependent extracellular signal-related kinase and c-Jun N-terminal kinase activation.

American journal of respiratory cell and molecular biology 20020801

Proteasome inhibition leads to NF-kappaB-independent IL-8 transactivation in human endothelial cells through induction of AP-1.

European journal of immunology 20020801

Expression of mutant alpha-synucleins enhances dopamine transporter-mediated MPP+ toxicity in vitro.

Neuroreport 20020719

Increased proteolysis after single-dose exposure with hepatotoxins in HepG2 cells.

Free radical biology & medicine 20020715

Aggresome formation in neuropathy models based on peripheral myelin protein 22 mutations.

Neurobiology of disease 20020701

The effect of proteasome inhibitors on mammalian erythroid terminal differentiation.

Experimental hematology 20020701

Troglitazone induces G1 arrest by p27(Kip1) induction that is mediated by inhibition of proteasome in human gastric cancer cells.

Japanese journal of cancer research : Gann 20020701

Nuclear localization of N-terminal mutant huntingtin is cell cycle dependent.

The European journal of neuroscience 20020701

Influence of peroxisome proliferator-activated receptor alpha agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and ApoB-48.

The Journal of biological chemistry 20020621

Helical apolipoproteins stabilize ATP-binding cassette transporter A1 by protecting it from thiol protease-mediated degradation.

The Journal of biological chemistry 20020621

Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effects.

Journal of neuroscience research 20020601

Proteasome inhibitors in the treatment of B-cell malignancies.

Clinical lymphoma 20020601

Development of an in-vitro model system to investigate the mechanism of muscle protein catabolism induced by proteolysis-inducing factor.

British journal of cancer 20020520

CXCR4/CCR5 down-modulation and chemotaxis are regulated by the proteasome pathway.

The Journal of biological chemistry 20020517

Biosynthesis and secretion of parathyroid hormone are sensitive to proteasome inhibitors in dispersed bovine parathyroid cells.

The Journal of biological chemistry 20020517

Ubiquitin/proteasome-dependent degradation of D-type cyclins is linked to tumor necrosis factor-induced cell cycle arrest.

The Journal of biological chemistry 20020510

Diffusional mobility of the cystic fibrosis transmembrane conductance regulator mutant, delta F508-CFTR, in the endoplasmic reticulum measured by photobleaching of GFP-CFTR chimeras.

The Journal of biological chemistry 20020510

An easily dissociated 26 S proteasome catalyzes an essential ubiquitin-mediated protein degradation pathway in Trypanosoma brucei.

The Journal of biological chemistry 20020503

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy.

Human molecular genetics 20020501

Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells.

Cancer research 20020501

Degradation of RXRs influences sensitivity of rat osteosarcoma cells to the antiproliferative effects of calcitriol.

Molecular endocrinology (Baltimore, Md.) 20020501

Effect of proteasome inhibitors on the growth, encystation, and excystation of Entamoeba histolytica and Entamoeba invadens.

Parasitology research 20020501

Differential effects of stress stimuli on a JNK-inactivating phosphatase.

Oncogene 20020404

Regulation of ornithine decarboxylase and polyamine import by hypoxia in pulmonary artery endothelial cells.

American journal of physiology. Lung cellular and molecular physiology 20020401

Proteasome inhibitors induce heat shock response and increase IL-6 expression in human intestinal epithelial cells.

American journal of physiology. Regulatory, integrative and comparative physiology 20020401

Proteasome implication in phorbol ester- and GnRH-induced selective down-regulation of PKC (alpha, epsilon, zeta) in alpha T(3)-1 and L beta T(2) gonadotrope cell lines.

Endocrinology 20020401

Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures.

Journal of neurochemistry 20020401

Long term regulation of aquaporin-2 expression in vasopressin-responsive renal collecting duct principal cells.

The Journal of biological chemistry 20020322

Efficient and qualitatively distinct MHC class I-restricted presentation of antigen targeted to the endoplasmic reticulum.

Journal of immunology (Baltimore, Md. : 1950) 20020315

Endotoxin stress-response in cardiomyocytes: NF-kappaB activation and tumor necrosis factor-alpha expression.

American journal of physiology. Heart and circulatory physiology 20020301

Presentation of a new H-2D(k)-restricted epitope in the Tax protein of human T-lymphotropic virus type I is enhanced by the proteasome inhibitor lactacystin.

The Journal of general virology 20020301

Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy.

Human molecular genetics 20020301

Proteasome inhibition reduces superantigen-mediated T cell activation and the severity of psoriasis in a SCID-hu model.

The Journal of clinical investigation 20020301

Analysis of Drosophila 26 S proteasome using RNA interference.

The Journal of biological chemistry 20020222

The molecular basis of glycogen storage disease type 1a: structure and function analysis of mutations in glucose-6-phosphatase.

The Journal of biological chemistry 20020215

Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation.

EMBO reports 20020215

Sensitivity of the origin decision point to specific inhibitors of cellular signaling and metabolism.

Experimental cell research 20020201

Retinal melatonin production: role of proteasomal proteolysis in circadian and photic control of arylalkylamine N-acetyltransferase.

Investigative ophthalmology & visual science 20020201

Involvement of proteasome in endothelin-1 production in cultured vascular endothelial cells.

Japanese journal of pharmacology 20020201

Proteasomal degradation of retinoblastoma-related p130 during adipocyte differentiation.

Biochemical and biophysical research communications 20020125

The glycoprotein gp48 of murine cytomegalovirusL proteasome-dependent cytosolic dislocation and degradation.

The Journal of biological chemistry 20020118

Chaperone interactions of the metalloproteinase meprin A in the secretory or proteasomal-degradative pathway.

Archives of biochemistry and biophysics 20020115

Proteasome inhibitors activate the transcription factors C/EBP-beta and delta in human intestinal epithelial cells.

Biochemical and biophysical research communications 20020111

Indomethacin induces differential expression of beta-catenin, gamma-catenin and T-cell factor target genes in human colorectal cancer cells.

Carcinogenesis 20020101

Ubiquitin-proteasome pathway is compromised in CD45RO+ and CD45RA+ T lymphocyte subsets during aging.

Experimental gerontology 20020101

Lipopolysaccharide supports survival and fusion of preosteoclasts independent of TNF-alpha, IL-1, and RANKL.

Journal of cellular physiology 20020101

Effect of geldanamycin on androgen receptor function and stability.

Cell stress & chaperones 20020101

Proteasome inhibitors.

Progress in molecular and subcellular biology 20020101

Differential processing of HLA A2-restricted HIV type 1 cytotoxic T lymphocyte epitopes.

Viral immunology 20020101

Proteasome inhibitors: complex tools for a complex enzyme.

Current topics in microbiology and immunology 20020101

A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs).

BMC cell biology 20020101

Mutant Rab24 GTPase is targeted to nuclear inclusions.

BMC cell biology 20020101

Numerous proteins in Mammalian cells are prone to iron-dependent oxidation and proteasomal degradation.

Developmental neuroscience 20020101

Genistein-induced apoptosis of p815 mastocytoma cells is mediated by Bax and augmented by a proteasome inhibitor, lactacystin.

Nutrition and cancer 20020101

The cyclin-dependent kinase inhibitor butyrolactone is a potent inhibitor of p21 (WAF1/CIP1 expression).

Cell cycle (Georgetown, Tex.) 20020101

[Embryonal stem cells do not undergo cell cycle arrest upon exposure to damaging factors].

Tsitologiia 20020101

Proteasome-dependent processing of nuclear proteins is correlated with their subnuclear localization.

Journal of structural biology 20020101

Lactacystin, a proteasome inhibitor, potentiates the apoptotic effect of parthenolide, an inhibitor of NFkappaB activation, on drug-resistant mouse leukemia L1210 cells.

Anticancer research 20020101

Differential effect of Bcl-xl over-expression on cell death of the monocytic leukemia cell line U937.

Anticancer research 20020101

Effects of proteasome inhibitors on the synaptic localization of Vesl-1S/Homer-1a proteins.

Brain research. Molecular brain research 20011230

Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway.

The Journal of biological chemistry 20011228

Protease inhibitors restore radiation-induced apoptosis to Bcl-2-expressing lymphoma cells.

International journal of cancer 20011220

Nedd4 regulates ubiquitination and stability of the guanine-nucleotide exchange factor CNrasGEF.

The Journal of biological chemistry 20011214

A transcriptionally inactive E2F-1 targets the MDM family of proteins for proteolytic degradation.

The Journal of biological chemistry 20011207

Redox regulation of human Rac1 stability by the proteasome in human aortic endothelial cells.

The Journal of biological chemistry 20011207

Photic regulation of melatonin in rat retina and the role of proteasomal proteolysis.

Neuroreport 20011204

Inhibition of proteasome activity blocks the ability of TNF alpha to down-regulate G(i) proteins and stimulate lipolysis.

Endocrinology 20011201

Identification and characterization of two novel mutations (Q421 K and R123P) in congenital factor XII deficiency.

Thrombosis and haemostasis 20011201

The ubiquitin-proteasome cascade is required for mammalian long-term memory formation.

The European journal of neuroscience 20011201

The proteasome participates in degradation of mutant alpha 1-antitrypsin Z in the endoplasmic reticulum of hepatoma-derived hepatocytes.

The Journal of biological chemistry 20011130

Divers pathways mediate delta-opioid receptor down regulation within the same cell.

Brain research. Molecular brain research 20011130

Role of ATP in influenza virus budding.

Virology 20011125

Ubiquitination precedes internalization and proteolytic cleavage of plasma membrane-bound glycine receptors.

The Journal of biological chemistry 20011116

Type 1 von Willebrand disease mutation Cys1149Arg causes intracellular retention and degradation of heterodimers: a possible general mechanism for dominant mutations of oligomeric proteins.

Blood 20011115

Proteasomal-dependent aggregate reversal and absence of cell death in a conditional mouse model of Huntington's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20011115

Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2.

The Journal of biological chemistry 20011026

A convenient method for 3-pyrroline synthesis.

Organic letters 20011018

Requirement for Mdm2 in the survival effects of Bcr-Abl and interleukin 3 in hematopoietic cells.

Cancer research 20011015

Akt1 induces extracellular matrix invasion and matrix metalloproteinase-2 activity in mouse mammary epithelial cells.

Cancer research 20011015

Proteasome inhibitors differentially affect heat shock protein response in cancer cells.

International journal of molecular medicine 20011001

Proteasomes and ubiquitin are involved in the turnover of the wild-type prion protein.

The EMBO journal 20011001

Proteasomal degradation of oxidatively damaged endogenous histones in K562 human leukemic cells.

Free radical biology & medicine 20011001

Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway.

Molecular cell 20011001

C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival.

Molecular cell 20011001

Proteasome activity is critical for the cAMP-induced differentiation of neuroblastoma cells.

Cellular and molecular neurobiology 20011001

Glycosylation increases potassium channel stability and surface expression in mammalian cells.

The Journal of biological chemistry 20010907

Neutrophils process exogenous bacteria via an alternate class I MHC processing pathway for presentation of peptides to T lymphocytes.

Journal of immunology (Baltimore, Md. : 1950) 20010901

Efficient presentation of both cytosolic and endogenous transmembrane protein antigens on MHC class II is dependent on cytoplasmic proteolysis.

Journal of immunology (Baltimore, Md. : 1950) 20010901

A measles virus glycoprotein-derived human CTL epitope is abundantly presented via the proteasomal-dependent MHC class I processing pathway.

The Journal of general virology 20010901

Proteasome inhibitor-induced apoptosis of B-chronic lymphocytic leukaemia cells involves cytochrome c release and caspase activation, accompanied by formation of an approximately 700 kDa Apaf-1 containing apoptosome complex.

Leukemia 20010901

H(2)O(2)-mediated oxidative stress activates NF-kappa B in lens epithelial cells.

Free radical biology & medicine 20010901

Proteolysis of oxidized proteins after oxygen-glucose deprivation in rat cortical neurons is mediated by the proteasome.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20010901

Antigen processing for MHC class I restricted presentation of exogenous influenza A virus nucleoprotein by B-lymphoblastoid cells.

Clinical and experimental immunology 20010901

Molecular therapy for multiple myeloma.

Haematologica 20010901

Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits.

Chemistry & biology 20010901

Proteasome inhibitors induce Fas-mediated apoptosis by c-Myc accumulation and subsequent induction of FasL message in human glioma cells.

FEBS letters 20010824

Proteasome inhibitors and immunosuppressive drugs promote the cleavage of eIF4GI and eIF4GII by caspase-8-independent mechanisms in Jurkat T cell lines.

FEBS letters 20010817

Effects of lipofectin-antigen complexes on major histocompatibility complex class I-restricted antigen presentation pathway in murine dendritic cells and on dendritic cell maturation.

Biochimica et biophysica acta 20010815

The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line.

The Journal of biological chemistry 20010810

Dendritic growth induced by BMP-7 requires Smad1 and proteasome activity.

Journal of neurobiology 20010801

Preventive effect of lactacystin, a selective proteasome inhibitor, on ischemic acute renal failure in rats.

The Journal of pharmacology and experimental therapeutics 20010801

Unexpected transcriptional induction of monocyte chemoattractant protein 1 by proteasome inhibition: involvement of the c-Jun N-terminal kinase-activator protein 1 pathway.

Journal of immunology (Baltimore, Md. : 1950) 20010801

Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells.

Journal of neurochemistry 20010801

Preconditioning-induced neuroprotection is mediated by reactive oxygen species and activation of the transcription factor nuclear factor-kappaB.

Journal of neurochemistry 20010801

Reversion of temperature-sensitive mutation by inhibition of proteasome-mediated degradation of mutated D123 protein.

Cell structure and function 20010801

Liver alcohol dehydrogenase is degraded by the ubiquitin-proteasome pathway.

Biochemical and biophysical research communications 20010720

Hypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm.

EMBO reports 20010707

Glucose regulates protein catabolism in ras-transformed fibroblasts through a lysosomal-dependent proteolytic pathway.

The Biochemical journal 20010701

Effect of proteasome inhibition on cellular oxidative damage, antioxidant defences and nitric oxide production.

Journal of neurochemistry 20010701

Transcriptionally and post-transcriptionally regulated response of 13 calmodulin genes to tobacco mosaic virus-induced cell death and wounding in tobacco plant.

European journal of biochemistry 20010701

Activation of ATP-ubiquitin-dependent proteolysis in skeletal muscle in vivo and murine myoblasts in vitro by a proteolysis-inducing factor (PIF).

British journal of cancer 20010701

Inducible nitric-oxide synthase is regulated by the proteasome degradation pathway.

The Journal of biological chemistry 20010629

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin.

Cell 20010629

Activation of NFkappaB and MnSOD gene expression by free radical scavengers in human microvascular endothelial cells.

Free radical biology & medicine 20010615

Stimulation of HIV gp120-specific cytolytic T lymphocyte responses in vitro and in vivo using a detoxified pertussis toxin vector.

AIDS research and human retroviruses 20010610

Clustering of peptide-loaded MHC class I molecules for endoplasmic reticulum export imaged by fluorescence resonance energy transfer.

Journal of immunology (Baltimore, Md. : 1950) 20010601

Protein oxidation and proteolysis by the nonradical oxidants singlet oxygen or peroxynitrite.

Free radical biology & medicine 20010601

Deoxycholic acid suppresses p53 by stimulating proteasome-mediated p53 protein degradation.

Carcinogenesis 20010601

cDNA expression arrays: the effects of lactacystin in lipopolysaccharide-induced cystitis.

Urology 20010601

Nuclear factor-kappaB is constitutively active in C-cell carcinoma and required for RET-induced transformation.

Cancer research 20010601

Antitumor bicyclic hexapeptide RA-VII modulates cyclin D1 protein level.

Anti-cancer drugs 20010601

Dexamethasone inhibits TNF-alpha-induced apoptosis and IAP protein downregulation in MCF-7 cells.

British journal of pharmacology 20010601

Impairment of the ubiquitin-proteasome system by protein aggregation.

Science (New York, N.Y.) 20010525

Down-regulation of MET, the receptor for hepatocyte growth factor.

Oncogene 20010517

Glutathiolation of the proteasome is enhanced by proteolytic inhibitors.

Archives of biochemistry and biophysics 20010515

A constitutive cytoprotective pathway protects endothelial cells from lipopolysaccharide-induced apoptosis.

The Journal of biological chemistry 20010504

A novel enantioselective synthetic route to omuralide analogues with the potential for species selectivity in proteasome inhibition.

Organic letters 20010503

Inhibitory effect of a presenilin 1 mutation on the Wnt signalling pathway by enhancement of beta-catenin phosphorylation.

European journal of biochemistry 20010501

Protein oxidation and proteolysis in RAW264.7 macrophages: effects of PMA activation.

Biochimica et biophysica acta 20010423

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis.

Human molecular genetics 20010415

Proteasome- and p38-dependent regulation of ERK3 expression.

The Journal of biological chemistry 20010406

BCR-ABL down-regulates the DNA repair protein DNA-PKcs.

Blood 20010401

Synergistic induction of apoptosis in human leukemia cells (U937) exposed to bryostatin 1 and the proteasome inhibitor lactacystin involves dysregulation of the PKC/MAPK cascade.

Blood 20010401

The glucocorticoid receptor interacting protein 1 (GRIP1) localizes in discrete nuclear foci that associate with ND10 bodies and are enriched in components of the 26S proteasome.

Molecular endocrinology (Baltimore, Md.) 20010401

Role of proteasomal degradation in the cell cycle-dependent regulation of DNA topoisomerase IIalpha expression.

Biochemical pharmacology 20010401

The levels of MDM2 protein are decreased by a proteasome-mediated proteolysis prior to caspase-3-dependent pRb and PARP cleavages.

Journal of Korean medical science 20010401

Apolipoprotein E in macrophages and hepatocytes is eegraded via the proteasomal pathway.

Biochemical and biophysical research communications 20010330

Proteasome activity is required for T lymphocyte aggregation after mitogen activation.

Journal of cellular biochemistry 20010326

Tumor necrosis factor-alpha induces distinctive NF-kappa B signaling within human dermal fibroblasts.

The Journal of biological chemistry 20010302

Proteasomes modulate balance among proapoptotic and antiapoptotic Bcl-2 family members and compromise functioning of the electron transport chain in leukemic cells.

Journal of immunology (Baltimore, Md. : 1950) 20010301

A mutation of the Wilson disease protein, ATP7B, is degraded in the proteasomes and forms protein aggregates.

Gastroenterology 20010301

Use of short-lived green fluorescent protein for the detection of proteasome inhibition.

BioTechniques 20010301

UCN-01 suppresses E2F-1 mediated by ubiquitin-proteasome-dependent degradation.

Clinical cancer research : an official journal of the American Association for Cancer Research 20010301

Pro-caspase-3 overexpression sensitises ovarian cancer cells to proteasome inhibitors.

Cell death and differentiation 20010301

c-Jun NH2-terminal kinase-mediated redox-dependent degradation of IkappaB: role of thioredoxin in NF-kappaB activation.

The Journal of biological chemistry 20010216

3-hydroxy-3-methylglutaryl coenzyme A reductase is sterol-dependently cleaved by cathepsin L-type cysteine protease in the isolated endoplasmic reticulum.

Archives of biochemistry and biophysics 20010215

Newly synthesized human delta opioid receptors retained in the endoplasmic reticulum are retrotranslocated to the cytosol, deglycosylated, ubiquitinated, and degraded by the proteasome.

The Journal of biological chemistry 20010209

Influence of proteasome and redox state on heat shock-induced activation of stress kinases, AP-1 and HSF.

Biochimica et biophysica acta 20010205

IFN-beta mediates coordinate expression of antigen-processing genes in RSV-infected pulmonary epithelial cells.

American journal of physiology. Lung cellular and molecular physiology 20010201

Oxidative stress inhibits the mitochondrial import of preproteins and leads to their degradation.

Experimental cell research 20010201

Tunicamycin induces ubiquitination and degradation of apolipoprotein B in HepG2 cells.

The Biochemical journal 20010201

Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult.

Journal of neurochemistry 20010201

The ubiquitin-proteasome pathway plays an essential role in proteolysis during Trypanosoma cruzi remodeling.

Biochemistry 20010130

Proteasomal function is impaired in substantia nigra in Parkinson's disease.

Neuroscience letters 20010119

The proteasome regulates receptor-mediated endocytosis of interleukin-2.

The Journal of biological chemistry 20010105

Ubiquitination of Lyn-kinase in rat basophilic leukemia RBL-2H3 cells.

Immunology letters 20010101

Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation.

Diabetes 20010101

Inhibition of proteasome activity by the TED4 protein in extracellular space: a novel mechanism for protection of living cells from injury caused by dying cells.

Plant & cell physiology 20010101

Proinflammatory cytokines and CD40 ligand enhance cross-presentation and cross-priming capability of human dendritic cells internalizing apoptotic cancer cells.

Journal of immunotherapy (Hagerstown, Md. : 1997) 20010101

Coordinate regulation of RARgamma2, TBP, and TAFII135 by targeted proteolysis during retinoic acid-induced differentiation of F9 embryonal carcinoma cells.

BMC molecular biology 20010101

Inhibition of NF-kappa B with proteasome inhibitors enhances apoptosis in human lung adenocarcinoma cells in vitro.

Anticancer research 20010101

[Effect of EGF on nuclear-cytoplasmic distribution of proteasomes in A-431 cells].

Tsitologiia 20010101

Characterization of membrane-associated proteasomes in WB rat liver epithelial cells.

Archives of biochemistry and biophysics 20010101

Lactacystin inhibits cathepsin A activity in melanoma cell lines.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20010101

Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons.

Neuroscience 20010101

Lactacystin enhances cisplatin sensitivity in resistant human ovarian cancer cell lines via inhibition of DNA repair and ERCC-1 expression.

Cellular and molecular biology (Noisy-le-Grand, France) 20010101

Proteasome inhibitors block intracellular growth and replication of Toxoplasma gondii.

Parasitology 20000701

Superinduction of CYP1A1 gene expression. Regulation of 2,3,7, 8-tetrachlorodibenzo-p-dioxin-induced degradation of Ah receptor by cycloheximide.

The Journal of biological chemistry 20000428

2,3,7,8-tetrachlorodibenzo-p-dioxin-induced degradation of aryl hydrocarbon receptor (AhR) by the ubiquitin-proteasome pathway. Role of the transcription activaton and DNA binding of AhR.

The Journal of biological chemistry 20000324

Cadmium-mediated oxidative stress in kidney proximal tubule cells induces degradation of Na+/K(+)-ATPase through proteasomal and endo-/lysosomal proteolytic pathways.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 19991001

Differential inhibition of three peptidase activities of the proteasome in human lens epithelium by heat and oxidation.

Experimental eye research 19990701

133343-34-7 | L-Cysteine, N-acetyl-S-[(3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-D-prolyl]-

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