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133059-99-1 | 4-Pyrimidinamine, N-ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-, hydrochloride (1:1)
CAS No: 133059-99-1 Catalog No: AG00145W MDL No:
Product Description
Catalog Number:
AG00145W
Chemical Name:
4-Pyrimidinamine, N-ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-, hydrochloride (1:1)
CAS Number:
133059-99-1
Molecular Formula:
C15H21ClN4
Molecular Weight:
292.8070
IUPAC Name:
N-ethyl-1,2-dimethyl-6-methylimino-N-phenylpyrimidin-4-amine;hydrochloride
InChI:
InChI=1S/C15H20N4.ClH/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15;/h6-11H,5H2,1-4H3;1H
InChI Key:
DUWKUHWHTPRMAP-UHFFFAOYSA-N
SMILES:
CCN(c1cc(=NC)n(c(n1)C)C)c1ccccc1.Cl
Properties
Complexity:
402
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
292.145g/mol
Formal Charge:
0
Heavy Atom Count:
20
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
292.811g/mol
Monoisotopic Mass:
292.145g/mol
Rotatable Bond Count:
3
Topological Polar Surface Area:
31.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Resonance properties of different neuronal populations in the immature mouse neocortex. | The European journal of neuroscience 20120901 |
| The role of area postrema neurons expressing H-channels in the induction mechanism of nausea and vomiting. | Physiology & behavior 20120820 |
| Adrenergic regulation of HCN4 channel requires protein association with β2-adrenergic receptor. | The Journal of biological chemistry 20120706 |
| Neuromodulation of I(h) in layer II medial entorhinal cortex stellate cells: a voltage-clamp study. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20120627 |
| Identification of a hyperpolarization-activated cyclic nucleotide-gated channel and its subtypes in the urinary bladder of the rat. | Urology 20120601 |
| SK- and h-current contribute to the generation of theta-like resonance of rat substantia nigra pars compacta dopaminergic neurons at hyperpolarized membrane potentials. | Brain structure & function 20120401 |
| An essential role for modulation of hyperpolarization-activated current in the development of binaural temporal precision. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20120222 |
| Selective sinoatrial node optical mapping and the mechanism of sinus rate acceleration. | Circulation journal : official journal of the Japanese Circulation Society 20120101 |
| The expression and role of hyperpolarization-activated and cyclic nucleotide-gated channels in endocrine anterior pituitary cells. | Molecular endocrinology (Baltimore, Md.) 20120101 |
| Know your current I(h): interaction with a shunting current explains the puzzling effects of its pharmacological or pathological modulations. | PloS one 20120101 |
| Targeted deletion of Kcne2 impairs HCN channel function in mouse thalamocortical circuits. | PloS one 20120101 |
| Diverse precerebellar neurons share similar intrinsic excitability. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20111116 |
| HCN channels expressed in the inner ear are necessary for normal balance function. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20111116 |
| Corticospinal-specific HCN expression in mouse motor cortex: I(h)-dependent synaptic integration as a candidate microcircuit mechanism involved in motor control. | Journal of neurophysiology 20111101 |
| Decreased hyperpolarization-activated currents in layer 5 pyramidal neurons enhances excitability in focal cortical dysplasia. | Journal of neurophysiology 20111101 |
| Perineural dexmedetomidine added to ropivacaine for sciatic nerve block in rats prolongs the duration of analgesia by blocking the hyperpolarization-activated cation current. | Anesthesiology 20111001 |
| The mechanism of ethanol action on midbrain dopaminergic neuron firing: a dynamic-clamp study of the role of I(h) and GABAergic synaptic integration. | Journal of neurophysiology 20111001 |
| The sound of silence: ionic mechanisms encoding sound termination. | Neuron 20110908 |
| Sound rhythms are encoded by postinhibitory rebound spiking in the superior paraolivary nucleus. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20110831 |
| The role of hyperpolarization-activated cationic current in spike-time precision and intrinsic resonance in cortical neurons in vitro. | The Journal of physiology 20110801 |
| The relationship between inflammation-induced neuronal excitability and disrupted motor activity in the guinea pig distal colon. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20110701 |
| Presynaptic nitric oxide/cGMP facilitates glutamate release via hyperpolarization-activated cyclic nucleotide-gated channels in the hippocampus. | The European journal of neuroscience 20110501 |
| Mechanism of spontaneous activity in afferent neurons of the zebrafish lateral-line organ. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20110202 |
| Pacemaker activity and ionic currents in mouse atrioventricular node cells. | Channels (Austin, Tex.) 20110101 |
| Countervailing modulation of Ih by neuropeptide Y and corticotrophin-releasing factor in basolateral amygdala as a possible mechanism for their effects on stress-related behaviors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20101215 |
| Mesolimbic dopamine neurons in the brain reward circuit mediate susceptibility to social defeat and antidepressant action. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20101208 |
| Hyperpolarization-activated cyclic nucleotide-gated channels in olfactory sensory neurons regulate axon extension and glomerular formation. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20101208 |
| A hyperpolarization-activated inward current alters swim frequency of the pteropod mollusk Clione limacina. | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20101201 |
| Ca2+ clock malfunction in a canine model of pacing-induced heart failure. | American journal of physiology. Heart and circulatory physiology 20101201 |
| Selective participation of somatodendritic HCN channels in inhibitory but not excitatory synaptic integration in neurons of the subthalamic nucleus. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20101124 |
| Hyperpolarization-activated currents in gonadotropin-releasing hormone (GnRH) neurons contribute to intrinsic excitability and are regulated by gonadal steroid feedback. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20101006 |
| Differential sensitivity of hippocampal interneurons to ethanol in adolescent and adult rats. | The Journal of pharmacology and experimental therapeutics 20101001 |
| Tachybradycardia in the isolated canine right atrium induced by chronic sympathetic stimulation and pacemaker current inhibition. | American journal of physiology. Heart and circulatory physiology 20100901 |
| Nicotine blocks the hyperpolarization-activated current Ih and severely impairs the oscillatory behavior of oriens-lacunosum moleculare interneurons. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100811 |
| Distinct modes of modulation of GABAergic transmission by Group I metabotropic glutamate receptors in rat entorhinal cortex. | Hippocampus 20100801 |
| The modulation of orexin A on HCN currents of pyramidal neurons in mouse prelimbic cortex. | Cerebral cortex (New York, N.Y. : 1991) 20100701 |
| Multiple effects of serotonin and acetylcholine on hyperpolarization-activated inward current in locomotor activity-related neurons in Cfos-EGFP mice. | Journal of neurophysiology 20100701 |
| Electrophysiological and morphological characteristics and synaptic connectivity of tyrosine hydroxylase-expressing neurons in adult mouse striatum. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100519 |
| ZD7288-induced suppression of long-term potentiation was attenuated by exogenous NMDA at the Schaffer collateral-CA1 synapse in the rat in vivo. | European journal of pharmacology 20100410 |
| TASK channels contribute to the K+-dominated leak current regulating respiratory rhythm generation in vitro. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100324 |
| Hyperpolarization-activated cation currents in human epileptogenic neocortex. | Epilepsia 20100301 |
| Homeostatic regulation of synaptic excitability: tonic GABA(A) receptor currents replace I(h) in cortical pyramidal neurons of HCN1 knock-out mice. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100217 |
| Induction of atrial ectopic beats with calcium release inhibition: Local hierarchy of automaticity in the right atrium. | Heart rhythm 20100101 |
| Hyperpolarization-activated current (I(h)) in ganglion-cell photoreceptors. | PloS one 20100101 |
| HCN1 channels constrain DHPG-induced LTD at hippocampal Schaffer collateral-CA1 synapses. | Learning & memory (Cold Spring Harbor, N.Y.) 20091201 |
| Origin of the fast negative ERG component from isolated aspartate-treated mouse retina. | Journal of vision 20091117 |
| Probing the bradycardic drug binding receptor of HCN-encoded pacemaker channels. | Pflugers Archiv : European journal of physiology 20091101 |
| Effects of XE991, retigabine, losigamone and ZD7288 on kainate-induced theta-like and gamma network oscillations in the rat hippocampus in vitro. | Brain research 20091027 |
| Intrathecal gabapentin does not act as a hyperpolarization-activated cyclic nucleotide-gated channel activator in the rat formalin test. | European journal of anaesthesiology 20091001 |
| Bidirectional control of spike timing by GABA(A) receptor-mediated inhibition during theta oscillation in CA1 pyramidal neurons. | Neuroreport 20090826 |
| Enhancement of Ih, but not inhibition of IM, is a key mechanism underlying the PACAP-induced increase in excitability of guinea pig intrinsic cardiac neurons. | American journal of physiology. Regulatory, integrative and comparative physiology 20090701 |
| Electrophysiological properties of octopus neurons of the cat cochlear nucleus: an in vitro study. | Journal of the Association for Research in Otolaryngology : JARO 20090601 |
| Dopamine depletion induced up-regulation of HCN3 enhances rebound excitability of basal ganglia output neurons. | Neurobiology of disease 20090401 |
| Activity-dependent depression of the spike after-depolarization generates long-lasting intrinsic plasticity in hippocampal CA3 pyramidal neurons. | The Journal of physiology 20090315 |
| Tramadol-induced block of hyperpolarization-activated cation current in rat pituitary lactotrophs. | Naunyn-Schmiedeberg's archives of pharmacology 20090201 |
| HCN1 channel subunits are a molecular substrate for hypnotic actions of ketamine. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20090121 |
| Developmental sensitivity of hippocampal interneurons to ethanol: involvement of the hyperpolarization-activated current, Ih. | Journal of neurophysiology 20090101 |
| Role of the hyperpolarization-activated current Ih in somatosensory neurons. | The Journal of physiology 20081215 |
| Funny currents are becoming serious players in nociceptor's sensitization. | The Journal of physiology 20081215 |
| Tuning of synaptic integration in the medial entorhinal cortex to the organization of grid cell firing fields. | Neuron 20081210 |
| Excitatory actions of peptide histidine isoleucine on thalamic relay neurons. | Neuropharmacology 20081201 |
| Conductances mediating intrinsic theta-frequency membrane potential oscillations in layer II parasubicular neurons. | Journal of neurophysiology 20081101 |
| Blunted excitability of aortic baroreceptor neurons in diabetic rats: involvement of hyperpolarization-activated channel. | Cardiovascular research 20080901 |
| Ethanol effects on dopaminergic ventral tegmental area neurons during block of Ih: involvement of barium-sensitive potassium currents. | Journal of neurophysiology 20080901 |
| Hyperpolarization-activated cyclic nucleotide-gated channels in mouse vomeronasal sensory neurons. | Journal of neurophysiology 20080801 |
| Transient cerebral ischemia increases CA1 pyramidal neuron excitability. | Experimental neurology 20080801 |
| ZD 7288 inhibits T-type calcium current in rat hippocampal pyramidal cells. | Neuroscience letters 20080718 |
| Gonadotropin-releasing hormone-1 neuronal activity is independent of hyperpolarization-activated cyclic nucleotide-modulated channels but is sensitive to protein kinase a-dependent phosphorylation. | Endocrinology 20080701 |
| Direct measurement of somatic voltage clamp errors in central neurons. | Nature neuroscience 20080701 |
| The h channel mediates location dependence and plasticity of intrinsic phase response in rat hippocampal neurons. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20080528 |
| Inhibition of Ih in striatal cholinergic interneurons early after transient forebrain ischemia. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20080501 |
| Dendritic Ih ensures high-fidelity dendritic spike responses of motion-sensitive neurons in rat superior colliculus. | Journal of neurophysiology 20080501 |
| Novel pharmacological activity of loperamide and CP-339,818 on human HCN channels characterized with an automated electrophysiology assay. | European journal of pharmacology 20080226 |
| Alpha2-adrenergic receptors modify dendritic spike generation via HCN channels in the prefrontal cortex. | Journal of neurophysiology 20080101 |
| Oxytocin-induced postinhibitory rebound firing facilitates bursting activity in oxytocin neurons. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20080101 |
| Effects of intrathecal injection of a hyperpolarization-activated channel (Ih) inhibitor ZD7288 on bladder function in urethane-anesthetized rats. | Neurourology and urodynamics 20080101 |
| HCN1 channels constrain synaptically evoked Ca2+ spikes in distal dendrites of CA1 pyramidal neurons. | Neuron 20071220 |
| A pharmacological model for calcium overload-induced tachycardia in isolated rat left atria. | European journal of pharmacology 20071208 |
| Intrinsic excitability of cholinergic neurons in the rat parabigeminal nucleus. | Journal of neurophysiology 20071201 |
| alpha2-Noradrenergic receptors activation enhances excitability and synaptic integration in rat prefrontal cortex pyramidal neurons via inhibition of HCN currents. | The Journal of physiology 20071015 |
| Molecular mapping of the binding site for a blocker of hyperpolarization-activated, cyclic nucleotide-modulated pacemaker channels. | The Journal of pharmacology and experimental therapeutics 20070901 |
| Inhibition of hyperpolarization-activated cation currents by phencyclidine and some sigma ligands in rat hippocampal CA1 pyramidal neurons in vitro. | Neuropharmacology 20070901 |
| Involvement of hyperpolarization-activated cation channels in synaptic modulation. | Neuroreport 20070806 |
| Voltage-sensitive conductances of bushy cells of the Mammalian ventral cochlear nucleus. | Journal of neurophysiology 20070601 |
| Ih without Kir in adult rat retinal ganglion cells. | Journal of neurophysiology 20070501 |
| Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex. | Cell 20070420 |
| Functional presynaptic HCN channels in the rat globus pallidus. | The European journal of neuroscience 20070401 |
| Opposing modifications in intrinsic currents and synaptic inputs in post-traumatic mossy cells: evidence for single-cell homeostasis in a hyperexcitable network. | Journal of neurophysiology 20070301 |
| Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic beta-cells. | Molecular endocrinology (Baltimore, Md.) 20070301 |
| The mGlu1 antagonist CPCCOEt enhances the climbing fibre response in Purkinje neurones independently of glutamate receptors. | Neuropharmacology 20070201 |
| Effects of serotonin on the intrinsic membrane properties of layer II medial entorhinal cortex neurons. | Hippocampus 20070101 |
| Pacemaking by HCN channels requires interaction with phosphoinositides. | Neuron 20061221 |
| Electrophysiological characterization of neurons in the dorsolateral pontine rapid-eye-movement sleep induction zone of the rat: Intrinsic membrane properties and responses to carbachol and orexins. | Neuroscience 20061201 |
| Compartmental distribution of hyperpolarization-activated cyclic-nucleotide-gated channel 2 and hyperpolarization-activated cyclic-nucleotide-gated channel 4 in thalamic reticular and thalamocortical relay neurons. | Neuroscience 20060915 |
| Modulation of thalamic neuron excitability by orexins. | Neuropharmacology 20060901 |
| The H current blocker ZD7288 decreases epileptiform hyperexcitability in the rat neocortex by depressing synaptic transmission. | Neuropharmacology 20060901 |
| Hyperpolarization-activated and cyclic nucleotide-gated cation channel subunit 2 ion channels modulate synaptic transmission from nociceptive primary afferents containing substance P to secondary sensory neurons in laminae I-IIo of the rodent spinal dorsal horn. | The European journal of neuroscience 20060901 |
| Alpha-2 adrenergic regulation of pedunculopontine nucleus neurons during development. | Neuroscience 20060825 |
| Characterization of hyperpolarization-activated current (Ih) in dorsal root ganglion neurons innervating rat urinary bladder. | Brain research 20060622 |
| Theta-frequency membrane resonance and its ionic mechanisms in rat subicular pyramidal neurons. | Neuroscience 20060619 |
| Environmental manipulations early in development alter seizure activity, Ih and HCN1 protein expression later in life. | The European journal of neuroscience 20060601 |
| Decreased IH in hippocampal area CA1 pyramidal neurons after perinatal seizure-inducing hypoxia. | Epilepsia 20060601 |
| ZD7288 inhibits the synaptic transmission in the pathway from perforant pathway fibers to CA3 region in rat hippocampus. | Yao xue xue bao = Acta pharmaceutica Sinica 20060601 |
| Expression of a functional hyperpolarization-activated current (Ih) in the mouse nucleus reticularis thalami. | Journal of neurophysiology 20060501 |
| Inhibition of Ih reduces epileptiform activity in rodent hippocampal slices. | Synapse (New York, N.Y.) 20060401 |
| Persistent changes in action potential broadening and the slow afterhyperpolarization in rat CA1 pyramidal cells after febrile seizures. | The European journal of neuroscience 20060401 |
| Fundamental importance of Na+-Ca2+ exchange for the pacemaking mechanism in guinea-pig sino-atrial node. | The Journal of physiology 20060315 |
| Neuronal basis of the slow (<1 Hz) oscillation in neurons of the nucleus reticularis thalami in vitro. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20060301 |
| Slow oscillatory activity of rat globus pallidus neurons in vitro. | The European journal of neuroscience 20060101 |
| Propofol block of I(h) contributes to the suppression of neuronal excitability and rhythmic burst firing in thalamocortical neurons. | The European journal of neuroscience 20060101 |
| Prenatal exposure to cigarette smoke affects the physiology of pedunculopontine nucleus (PPN) neurons in development. | Neurotoxicology and teratology 20060101 |
| Suppression of ih contributes to propofol-induced inhibition of mouse cortical pyramidal neurons. | Journal of neurophysiology 20051201 |
| Excitatory actions of dopamine via D1-like receptors in the rat lateral geniculate nucleus. | Journal of neurophysiology 20051201 |
| Activity-dependent decrease of excitability in rat hippocampal neurons through increases in I(h). | Nature neuroscience 20051101 |
| Synchronized network activity in developing rat hippocampus involves regional hyperpolarization-activated cyclic nucleotide-gated (HCN) channel function. | The European journal of neuroscience 20051101 |
| Impaired regulation of thalamic pacemaker channels through an imbalance of subunit expression in absence epilepsy. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20051026 |
| Single channel properties of hyperpolarization-activated cation currents in acutely dissociated rat hippocampal neurones. | The Journal of physiology 20051015 |
| Functional expression of the human HCN3 channel. | The Journal of biological chemistry 20051014 |
| Corticotrophin-releasing factor augments the I(H) in rat hypothalamic paraventricular nucleus parvocellular neurons in vitro. | Journal of neurophysiology 20050701 |
| Physiology and pharmacology of the cardiac pacemaker ('funny') current. | Pharmacology & therapeutics 20050701 |
| Persistent sodium currents in mesencephalic v neurons participate in burst generation and control of membrane excitability. | Journal of neurophysiology 20050501 |
| cAMP-mediated mechanisms for pain sensitization during opioid withdrawal. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050413 |
| Intraglomerular inhibition: signaling mechanisms of an olfactory microcircuit. | Nature neuroscience 20050301 |
| Excitability of auditory brainstem neurons, in vivo, is increased by cyclic-AMP. | Hearing research 20050301 |
| Modulation of spontaneous firing in rat subthalamic neurons by 5-HT receptor subtypes. | Journal of neurophysiology 20050301 |
| Molecular and functional characterization of an I(h)-channel from lobster olfactory receptor neurons. | The European journal of neuroscience 20050301 |
| The mechanism of intrinsic amplification of hyperpolarizations and spontaneous bursting in striatal cholinergic interneurons. | Neuron 20050217 |
| Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers. | Circulation 20050104 |
| Suppression by an h current of spontaneous Na+ action potentials in human cone and rod photoreceptors. | Investigative ophthalmology & visual science 20050101 |
| Electrophysiological properties and thermosensitivity of mouse preoptic and anterior hypothalamic neurons in culture. | Neuroscience 20050101 |
| Pituitary adenylate cyclase-activating polypeptide enhances the hyperpolarization-activated nonselective cationic conductance, Ih, in dissociated guinea pig intracardiac neurons. | Regulatory peptides 20041215 |
| Frequency-dependent modulation of retinogeniculate transmission by serotonin. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20041201 |
| Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neurons. | Neuron 20041028 |
| Contribution of Ih and GABAB to synaptically induced afterhyperpolarizations in CA1: a brake on the NMDA response. | Journal of neurophysiology 20041001 |
| Characterization of the human HCN1 channel and its inhibition by capsazepine. | British journal of pharmacology 20041001 |
| In vivo contribution of h-channels in the septal pacemaker to theta rhythm generation. | The European journal of neuroscience 20041001 |
| Clonidine prolongation of lidocaine analgesia after sciatic nerve block in rats Is mediated via the hyperpolarization-activated cation current, not by alpha-adrenoreceptors. | Anesthesiology 20040801 |
| An impaired neocortical Ih is associated with enhanced excitability and absence epilepsy. | The European journal of neuroscience 20040601 |
| Input resistance is voltage dependent due to activation of Ih channels in rat CA1 pyramidal cells. | Journal of neuroscience research 20040515 |
| Roles of Ca2+, hyperpolarization and cyclic nucleotide-activated channel activation, and actin in temporal synaptic tagging. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20040428 |
| Characterisation of hyperpolarization-activated currents (I(h)) in the medial septum/diagonal band complex in the mouse. | Brain research 20040423 |
| Hippocampal theta rhythm is reduced by suppression of the H-current in septohippocampal GABAergic neurons. | The European journal of neuroscience 20040401 |
| ZD7288 inhibits postsynaptic glutamate receptor-mediated responses at hippocampal perforant path-granule cell synapses. | The European journal of neuroscience 20040201 |
| The sleep-modulating peptide cortistatin augments the h-current in hippocampal neurons. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20031126 |
| Gamma oscillations induced by kainate receptor activation in the entorhinal cortex in vitro. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20031029 |
| Unmyelinated axons in the rat hippocampus hyperpolarize and activate an H current when spike frequency exceeds 1 Hz. | The Journal of physiology 20031015 |
| Role of the hyperpolarization-activated cation current (Ih) in pacemaker activity in area postrema neurons of rat brain slices. | The Journal of physiology 20031001 |
| Distinct electrophysiological properties of glutamatergic, cholinergic and GABAergic rat septohippocampal neurons: novel implications for hippocampal rhythmicity. | The Journal of physiology 20030915 |
| A simulation analysis on mechanisms of damped oscillation in retinal rod photoreceptor cells. | Vision research 20030901 |
| Hyperpolarization-activated (I(h)) conductances affect brainstem auditory neuron excitability. | Hearing research 20030901 |
| Vasoactive intestinal peptide selectively depolarizes thalamic relay neurons and attenuates intrathalamic rhythmic activity. | Journal of neurophysiology 20030801 |
| Ethanol excitation of dopaminergic ventral tegmental area neurons is blocked by quinidine. | The Journal of pharmacology and experimental therapeutics 20030801 |
| Local anaesthetics block hyperpolarization-activated inward current in rat small dorsal root ganglion neurones. | British journal of pharmacology 20030801 |
| Dorsal and ventral distribution of excitable and synaptic properties of neurons of the bed nucleus of the stria terminalis. | Journal of neurophysiology 20030701 |
| Reexamination of the role of hyperpolarization-activated cation channels in short- and long-term plasticity at hippocampal mossy fiber synapses. | Neuropharmacology 20030601 |
| Sinus tachyarrhythmias and the specific bradycardic agents: a marriage made in heaven? | Journal of cardiovascular pharmacology and therapeutics 20030601 |
| Kappa-opioid receptor-mediated enhancement of the hyperpolarization-activated current (I(h)) through mobilization of intracellular calcium in rat nucleus raphe magnus. | The Journal of physiology 20030501 |
| The role of the hyperpolarization-activated cationic current I(h) in the timing of interictal bursts in the neonatal hippocampus. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030501 |
| Ih channels as modulators of presynaptic terminal function: ZD7288 increases NMDA-evoked [3H]-noradrenaline release in rat neocortex slices. | Naunyn-Schmiedeberg's archives of pharmacology 20030401 |
| Activation of Ih is necessary for patterning of mGluR and mAChR induced network activity in the hippocampal CA3 region. | Neuropharmacology 20030301 |
| Development of inward rectification and control of membrane excitability in mesencephalic v neurons. | Journal of neurophysiology 20030301 |
| Ih blockers have a potential of antiepileptic effects. | Epilepsia 20030101 |
| Postnatal development of the hyperpolarization-activated excitatory current Ih in mouse hippocampal pyramidal neurons. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20021015 |
| Blockade of hyperpolarization-activated channels modifies the effect of beta-adrenoceptor stimulation. | Bulletin of experimental biology and medicine 20020501 |
| Characteristics of hyperpolarization-activated cation currents in portal vein smooth muscle cells. | American journal of physiology. Cell physiology 20020401 |
| Influence of the hyperpolarization-activated cation current, I(h), on the electrotonic properties of the distal apical dendrites of hippocampal CA1 pyramidal neurones. | Brain research 20020315 |
| I(h) channels contribute to the different functional properties of identified dopaminergic subpopulations in the midbrain. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20020215 |
| Muscarinic induction of hippocampal gamma oscillations requires coupling of the M1 receptor to two mixed cation currents. | Neuron 20020214 |
| Mediation of hippocampal mossy fiber long-term potentiation by presynaptic Ih channels. | Science (New York, N.Y.) 20020104 |
| NO-cGMP pathway increases the hyperpolarisation-activated current, I(f), and heart rate during adrenergic stimulation. | Cardiovascular research 20011201 |
| Ionic basis of the caesium-induced depolarisation in rat supraoptic nucleus neurones. | The Journal of physiology 20011101 |
| Contribution of the hyperpolarization-activated current (I(h)) to membrane potential and GABA release in hippocampal interneurons. | Journal of neurophysiology 20010701 |
| Dendritic mechanisms of phase precession in hippocampal CA1 pyramidal neurons. | Journal of neurophysiology 20010701 |
| Modulation of the hyperpolarisation-activated current, Ih, in rat facial motoneurones in vitro by ZD-7288. | Neuropharmacology 20010601 |
| Evidence for a modulatory role of Ih on the firing of a subgroup of midbrain dopamine neurons. | Neuroreport 20010212 |
| High I(h) channel density in the distal apical dendrite of layer V pyramidal cells increases bidirectional attenuation of EPSPs. | Journal of neurophysiology 20010201 |
| Inhibition of the I(h) current in isolated peripheral nerve: a novel mode of peripheral antinociception? | Muscle & nerve 20010201 |
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