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133052-90-1

133052-90-1 | 1H-Pyrrole-2,5-dione, 3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-

CAS No: 133052-90-1 Catalog No: AG0011LB MDL No:MFCD00236428

Product Description

Catalog Number:
AG0011LB
Chemical Name:
1H-Pyrrole-2,5-dione, 3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-
CAS Number:
133052-90-1
Molecular Formula:
C25H24N4O2
Molecular Weight:
412.4837
MDL Number:
MFCD00236428
IUPAC Name:
3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione
InChI:
InChI=1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31)
InChI Key:
QMGUOJYZJKLOLH-UHFFFAOYSA-N
SMILES:
CN(CCCn1cc(c2c1cccc2)C1=C(C(=O)NC1=O)c1c[nH]c2c1cccc2)C
UNII:
L79H6N0V6C

Properties

Complexity:
748  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
412.19g/mol
Formal Charge:
0
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
412.493g/mol
Monoisotopic Mass:
412.19g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
70.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.1  

Literature

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Ghrelin signaling in human mesenteric arteries. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20100801
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Novel antileukemic compound ingenol 3-angelate inhibits T cell apoptosis by activating protein kinase Ctheta. The Journal of biological chemistry 20100730
Melatonin potentiates glycine currents through a PLC/PKC signalling pathway in rat retinal ganglion cells. The Journal of physiology 20100715
The modulation of orexin A on HCN currents of pyramidal neurons in mouse prelimbic cortex. Cerebral cortex (New York, N.Y. : 1991) 20100701
High glucose regulates cyclin D1/E of human mesenchymal stem cells through TGF-beta1 expression via Ca2+/PKC/MAPKs and PI3K/Akt/mTOR signal pathways. Journal of cellular physiology 20100701
Phorbol ester phorbol-12-myristate-13-acetate induces epithelial to mesenchymal transition in human prostate cancer ARCaPE cells. The Prostate 20100701
PKC alpha phosphorylates cytosolic NF-kappaB/p65 and PKC delta delays nuclear translocation of NF-kappaB/p65 in U1242 glioblastoma cells. Turkish neurosurgery 20100701
Protein kinase Ctheta negatively regulates store-independent Ca2+ entry and phosphatidylserine exposure downstream of glycoprotein VI in platelets. The Journal of biological chemistry 20100625
L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience 20100616
Transforming growth factor beta1 enhances tumor promotion in mouse skin carcinogenesis. Carcinogenesis 20100601
Quantitative assessment of neurite outgrowth in human embryonic stem cell-derived hN2 cells using automated high-content image analysis. Neurotoxicology 20100601
Gonadotropin-induced ovarian cancer cell migration and proliferation require extracellular signal-regulated kinase 1/2 activation regulated by calcium and protein kinase C{delta}. Endocrine-related cancer 20100601
Plato's cave algorithm: inferring functional signaling networks from early gene expression shadows. PLoS computational biology 20100601
Phosphatidic acid is a leukocyte chemoattractant that acts through S6 kinase signaling. The Journal of biological chemistry 20100521
Activation of L-type Ca2+ channels by protein kinase C is reduced in smooth muscle-specific Na+/Ca2+ exchanger knockout mice. American journal of physiology. Heart and circulatory physiology 20100501
Translocation of protein kinase C isoforms is involved in propofol-induced endothelial nitric oxide synthase activation. British journal of anaesthesia 20100501
Calcitonin gene-related peptide- and adrenomedullin-induced facilitation of calcium current by different signal pathways in nucleus tractus solitarius. Brain research 20100423
Puerarin suppresses AGEs-induced inflammation in mouse mesangial cells: a possible pathway through the induction of heme oxygenase-1 expression. Toxicology and applied pharmacology 20100415
Protein kinase C mediated intracellular signaling pathways are involved in the regulation of sodium-dependent glucose co-transporter SGLT1 activity. Journal of cellular biochemistry 20100415
Rapid modulation of the organic anion transporting polypeptide 2B1 (OATP2B1, SLCO2B1) function by protein kinase C-mediated internalization. The Journal of biological chemistry 20100409
Regulation of VDR expression in rat and human intestine and liver--consequences for CYP3A expression. Toxicology in vitro : an international journal published in association with BIBRA 20100401
Enhancement of glucagon secretion in mouse and human pancreatic alpha cells by protein kinase C (PKC) involves intracellular trafficking of PKCalpha and PKCdelta. Diabetologia 20100401
Protein kinase C regulates neurite outgrowth in spinal cord neurons. Neuroscience bulletin 20100401
Pituitary adenylate cyclase-activating polypeptide (PACAP)/PAC1HOP1 receptor activation coordinates multiple neurotrophic signaling pathways: Akt activation through phosphatidylinositol 3-kinase gamma and vesicle endocytosis for neuronal survival. The Journal of biological chemistry 20100326
Insulin modulates protease-activated receptor 2 signaling: implications for the innate immune response. Journal of immunology (Baltimore, Md. : 1950) 20100301
[Protein kinase C activation is required for free fatty acid-induced impairment of endothelial nitric oxide synthase]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20100301
Identification of Thr29 as a critical phosphorylation site that activates the human proton channel Hvcn1 in leukocytes. The Journal of biological chemistry 20100219
Discovery of a novel class of targeted kinase inhibitors that blocks protein kinase C signaling and ameliorates retinal vascular leakage in a diabetic rat model. European journal of pharmacology 20100210
Role of HuR and p38MAPK in ultraviolet B-induced post-transcriptional regulation of COX-2 expression in the human keratinocyte cell line HaCaT. The Journal of biological chemistry 20100205
Phenolic fraction of tobacco smoke condensate potentiates benzo[a]pyerene diol epoxide-induced cell transformation: role of protein kinase C. Mutation research 20100202
Filamin A is required for vimentin-mediated cell adhesion and spreading. American journal of physiology. Cell physiology 20100201
Proteinase-activated receptor-2 mediated inhibition of TNFalpha-stimulated JNK activation - A novel paradigm for G(q/11) linked GPCRs. Cellular signalling 20100201
Protein kinase C-mediated inhibition of recombinant T-type Cav3.2 channels by neurokinin 1 receptors. Molecular pharmacology 20100201
The effect of midazolam on mouse Leydig cell steroidogenesis and apoptosis. Toxicology letters 20100201
Reduction of protein kinase C delta attenuates tenascin-C stimulated glioma invasion in three-dimensional matrix. Carcinogenesis 20100201
Enzastaurin induces H2AX phosphorylation to regulate apoptosis via MAPK signalling in malignant glioma cells. European journal of cancer (Oxford, England : 1990) 20100101
Rac/ROS-related protein kinase C and phosphatidylinositol-3-kinase signaling are involved in a negative regulating cascade in B cell activation by antibody-mediated cross-linking of MHC class II molecules. Molecular immunology 20100101
Microbial alkaloid staurosporine induces formation of nanometer-wide membrane tubular extensions (cytonemes, membrane tethers) in human neutrophils. Cell adhesion & migration 20100101
Facilitation of synaptic transmission and pain responses by CGRP in the amygdala of normal rats. Molecular pain 20100101
Engineered heart tissue: a novel tool to study the ischemic changes of the heart in vitro. PloS one 20100101
Regulation of P-glycoprotein in renal proximal tubule epithelial cells by LPS and TNF-alpha. Journal of biomedicine & biotechnology 20100101
Synthesis and antitumor activity of bisindolylmaleimide and amino acid ester conjugates. Journal of Asian natural products research 20100101
Novel anti-infective compounds from marine bacteria. Marine drugs 20100101
Proteomic profiling of human keratinocytes undergoing UVB-induced alternative differentiation reveals TRIpartite Motif Protein 29 as a survival factor. PloS one 20100101
Differential cytokine regulation by NF-kappaB and AP-1 in Jurkat T-cells. BMC immunology 20100101
Inhibition of gap junctional Intercellular communication in WB-F344 rat liver epithelial cells by triphenyltin chloride through MAPK and PI3-kinase pathways. Journal of occupational medicine and toxicology (London, England) 20100101
Peroxynitrite causes phosphorylation of vasodilator-stimulated phosphoprotein through a PKC dependent mechanism. Platelets 20100101
VEGF stimulates RCAN1.4 expression in endothelial cells via a pathway requiring Ca2+/calcineurin and protein kinase C-delta. PloS one 20100101
Menthol response and adaptation in nociceptive-like and nonnociceptive-like neurons: role of protein kinases. Molecular pain 20100101
Higher concentrations of extracellular ATP suppress proliferation of Caco-2 human colonic cancer cells via an unknown receptor involving PKC inhibition. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101
Auto-positive feedback regulation for nicotinic acetylcholine receptors by protein kinase C activation. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101
The participation of NMDA receptors, PKC, and MAPK in the formation of memory following operant conditioning in Lymnaea. Molecular brain 20100101
Mechanical stress activates Smad pathway through PKCδ to enhance interleukin-11 gene transcription in osteoblasts. PloS one 20100101
ER-α36, a novel variant of ER-α, mediates estrogen-stimulated proliferation of endometrial carcinoma cells via the PKCδ/ERK pathway. PloS one 20100101
Involvement of lysophosphatidic acid in bone cancer pain by potentiation of TRPV1 via PKCε pathway in dorsal root ganglion neurons. Molecular pain 20100101
Potentiation of excitatory transmission in substantia gelatinosa neurons of rat spinal cord by inhibition of estrogen receptor alpha. Molecular pain 20100101
Ubiquitination participates in the lysosomal degradation of Na,K-ATPase in steady-state conditions. American journal of respiratory cell and molecular biology 20091201
Protein kinase C epsilon is involved in ionizing radiation induced bystander response in human cells. The international journal of biochemistry & cell biology 20091201
Ethanol alters the expressions of c-Fos and myelin basic protein in differentiating oligodendrocytes. Alcohol (Fayetteville, N.Y.) 20091201
The hunt for natural skin whitening agents. International journal of molecular sciences 20091201
Potentiation of spinal NMDA-mediated nociception by cocaine- and amphetamine-regulated transcript peptide via PKA and PKC signaling pathways in rats. Regulatory peptides 20091127
Growth hormone-releasing peptide-2 stimulates secretion and synthesis of adrenocorticotropic hormone in mouse pituitary. Regulatory peptides 20091127
Nitro-aspirin inhibits MCF-7 breast cancer cell growth: effects on COX-2 expression and Wnt/beta-catenin/TCF-4 signaling. Biochemical pharmacology 20091115
Mediation of protein kinase C zeta in mu-opioid receptor activation for increase of glucose uptake into cultured myoblast C2C12 cells. Neuroscience letters 20091113
Sphingosine 1-phosphate regulation of extracellular signal-regulated kinase-1/2 in embryonic stem cells. Stem cells and development 20091101
Protein kinase C delta-mediated processes in cholecystokinin-8-stimulated pancreatic acini. Pancreas 20091101
Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes. Journal of medicinal chemistry 20091022
Activation of the TRPV4 ion channel is enhanced by phosphorylation. The Journal of biological chemistry 20091009
Rescue of functional F508del cystic fibrosis transmembrane conductance regulator by vasoactive intestinal peptide in the human nasal epithelial cell line JME/CF15. The Journal of pharmacology and experimental therapeutics 20091001
Pyridoxine inhibits depolarization-evoked glutamate release in nerve terminals from rat cerebral cortex: a possible neuroprotective mechanism? The Journal of pharmacology and experimental therapeutics 20091001
Neurokinins inhibit low threshold inactivating K+ currents in capsaicin responsive DRG neurons. Experimental neurology 20091001
Mechanoregulation of BK channel activity in the mammalian cortical collecting duct: role of protein kinases A and C. American journal of physiology. Renal physiology 20091001
Modulation of K(ATP) currents in rat ventricular myocytes by hypoxia and a redox reaction. Acta pharmacologica Sinica 20091001
Role of calcineurin-mediated dephosphorylation in modulation of an inwardly rectifying K+ channel in human proximal tubule cells. The Journal of membrane biology 20091001
Phosphorylation of histone H3 by protein kinase C signaling plays a critical role in the regulation of the developmentally important TBX2 gene. The Journal of biological chemistry 20090925
Vasoactive intestinal peptide acts via multiple signal pathways to regulate hippocampal NMDA receptors and synaptic transmission. Hippocampus 20090901
Protein kinase C signalling during miracidium to mother sporocyst development in the helminth parasite, Schistosoma mansoni. International journal for parasitology 20090901
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism. American journal of physiology. Renal physiology 20090901
Modulation of ileal apical Na+-dependent bile acid transporter ASBT by protein kinase C. American journal of physiology. Gastrointestinal and liver physiology 20090901
Negation of the cancer-preventive actions of selenium by over-expression of protein kinase Cepsilon and selenoprotein thioredoxin reductase. Carcinogenesis 20090901
Signal pathways regulating hyaluronan secretion into static and cycled synovial joints of rabbits. The Journal of physiology 20090901
Differential fading of inhibitory and excitatory B2 bradykinin receptor responses in rat sympathetic neurons: a role for protein kinase C. Journal of neurochemistry 20090901
Functional study of the effect of phosphatase inhibitors on KCNQ4 channels expressed in Xenopus oocytes. Acta pharmacologica Sinica 20090901
Protective effect of Lycium barbarum polysaccharide 4 on kidneys in streptozotocin-induced diabetic rats. Canadian journal of physiology and pharmacology 20090901
Mechanisms of nuclear vitamin D receptor resistance in Harvey-ras-transfected cells. The Journal of nutritional biochemistry 20090801
Roles of protein kinase C isotypes during seawater-versus cAMP-induced oocyte maturation in a marine worm. Molecular reproduction and development 20090801
Substance P enhances excitatory synaptic transmission on spinally projecting neurons in the rostral ventromedial medulla after inflammatory injury. Journal of neurophysiology 20090801
Capture of drug targets from live cells using a multipurpose immuno-chemo-proteomics tool. Journal of proteome research 20090801
Identification of bisindolylmaleimides and indolocarbazoles as inhibitors of HCV replication by tube-capture-RT-PCR. Antiviral research 20090801
Inhibition of P2X receptor-mediated inward current by protein kinase C in small-diameter dorsal root ganglion neurons of adult rats. Neuroscience bulletin 20090801
Rottlerin protected dopaminergic cell line from cytotoxicity of 6-hydroxydopamine by inhibiting PKCdelta phosphorylation. Neuroscience bulletin 20090801
High glucose induces transactivation of the alpha2-HS glycoprotein gene through the ERK1/2 signaling pathway. Journal of atherosclerosis and thrombosis 20090801
Theoretical study of photophysical properties of bisindolylmaleimide derivatives. The journal of physical chemistry. A 20090723
Protein kinase C isoforms differentially phosphorylate Ca(v)1.2 alpha(1c). Biochemistry 20090721
Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death. Bioorganic & medicinal chemistry 20090715
Involvement of protein kinase C in the regulation of Na+/Ca2+ exchanger in bovine adrenal chromaffin cells. Clinical and experimental pharmacology & physiology 20090701
Regulation of c-Fos and c-Jun gene expression by phospholipase C activity in adult cardiomyocytes. Molecular and cellular biochemistry 20090701
Mechanisms of protein kinase C signaling in the modulation of 3',5'-cyclic adenosine monophosphate-mediated steroidogenesis in mouse gonadal cells. Endocrinology 20090701
Paclitaxel and vinorelbine, evoked the release of substance P from cultured rat dorsal root ganglion cells through different PKC isoform-sensitive ion channels. Neuropharmacology 20090701
Alteration of the PKC-mediated signaling pathway for smooth muscle contraction in obstruction-induced hypertrophy of the urinary bladder. Laboratory investigation; a journal of technical methods and pathology 20090701
Pterostilbene inhibited tumor invasion via suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells. Carcinogenesis 20090701
Pituitary adenylate cyclase-activating polypeptide induces somatolactin release from cultured goldfish pituitary cells. Peptides 20090701
Protein kinase C mediates the effects of delta-opioid receptor stimulation on survival and apoptosis in neonatal cardiomyocytes cultured in serum-deprived condition. Die Pharmazie 20090701
The angiotensin II-AT1 receptor stimulates reactive oxygen species within the cell nucleus. Biochemical and biophysical research communications 20090626
Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles. Journal of medicinal chemistry 20090625
5'-N-ethylcarboxamide induces IL-6 expression via MAPKs and NF-kappaB activation through Akt, Ca(2+)/PKC, cAMP signaling pathways in mouse embryonic stem cells. Journal of cellular physiology 20090601
Protein kinase C iota mediates lipid-induced apoptosis of human coronary artery endothelial cells. Microvascular research 20090601
Antitumor compounds from marine actinomycetes. Marine drugs 20090601
Visualization of dopamine transporter trafficking in live neurons by use of fluorescent cocaine analogs. The Journal of neuroscience : the official journal of the Society for Neuroscience 20090527
Protein kinase D mediates mitogenic signaling by Gq-coupled receptors through protein kinase C-independent regulation of activation loop Ser744 and Ser748 phosphorylation. The Journal of biological chemistry 20090515
Modulation of rat neutrophil function in vitro by cis- and trans-MUFA. The British journal of nutrition 20090501
Protein kinase C in heart failure: a therapeutic target? Cardiovascular research 20090501
Calcineurin and cytoskeleton in low-frequency depression. Journal of neurochemistry 20090501
Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor. The Journal of biological chemistry 20090501
Akt demoted in glioblastoma. Science signaling 20090421
Parathyroid hormone synergizes with non-cyclic AMP pathways to activate the cyclic AMP response element. Journal of cellular biochemistry 20090401
Adenosine A2A receptors enhance GABA transport into nerve terminals by restraining PKC inhibition of GAT-1. Journal of neurochemistry 20090401
Vascular endothelial cells and smooth muscle cells mediate carbachol-induced hepatocyte proliferation via muscarinic receptors and IP3/PKC signaling cascades. Cell biology international 20090401
p66Shc links alpha1-adrenergic receptors to a reactive oxygen species-dependent AKT-FOXO3A phosphorylation pathway in cardiomyocytes. Circulation research 20090313
Interleukin-6 promotes 2-deoxyglucose uptake through p44/42 MAPKs activation via Ca2+/PKC and EGF receptor in primary cultured chicken hepatocytes. Journal of cellular physiology 20090301
Norfuraneol dephosphorylates eNOS at threonine 495 and enhances eNOS activity in human endothelial cells. Cardiovascular research 20090301
Rapid substrate-induced down-regulation in function and surface localization of dopamine transporters: rat dorsal striatum versus nucleus accumbens. Journal of neurochemistry 20090301
Thiamylal and thiopental attenuate beta-adrenergic signaling pathway by suppressing adenylyl cyclase in rat ventricular myocytes. Hiroshima journal of medical sciences 20090301
Purinergic activation of a leak potassium current in freshly dissociated myocytes from mouse thoracic aorta. Acta physiologica (Oxford, England) 20090201
Role of HIF-1alpha and VEGF in human mesenchymal stem cell proliferation by 17beta-estradiol: involvement of PKC, PI3K/Akt, and MAPKs. American journal of physiology. Cell physiology 20090201
Role of protein kinase Czeta and calcium entry in KCl-induced vascular smooth muscle calcium sensitization and feedback control of cellular calcium levels. The Journal of pharmacology and experimental therapeutics 20090201
PKC-dependent stimulation of the human MCT1 promoter involves transcription factor AP2. American journal of physiology. Gastrointestinal and liver physiology 20090201
Induction of COX-2 in human airway cells by manganese: role of PI3K/PKB, p38 MAPK, PKCs, Src, and glutathione depletion. Toxicology in vitro : an international journal published in association with BIBRA 20090201
Role of Ca2+ mobilization and Ca2+ sensitization in 8-iso-PGF 2 alpha-induced contraction in airway smooth muscle. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20090201
Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling. Brain : a journal of neurology 20090201
Involvement of GSK-3 in regulation of murine embryonic stem cell self-renewal revealed by a series of bisindolylmaleimides. Chemistry & biology 20090130
NADPH oxidase and hydrogen peroxide mediate insulin-induced calcium increase in skeletal muscle cells. The Journal of biological chemistry 20090123
Concomitant activation of adenylyl cyclase suppresses the opposite influences of CB(1) cannabinoid receptor agonists on tyrosine hydroxylase expression. Biochemical pharmacology 20090115
Peripheral delta opioid receptors require priming for functional competence in vivo. European journal of pharmacology 20090114
Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. Journal of medicinal chemistry 20090108
Peroxynitrite participates in mechanisms involved in capacitation of cryopreserved cattle. Animal reproduction science 20090101
Adreno-muscarinic synergy in the bladder trigone: calcium-dependent and -independent mechanisms. Cell calcium 20090101
The role of P38 MAPK and PKC in BLP induced TNF-alpha release, apoptosis, and NFkappaB activation in THP-1 monocyte cells. The Journal of surgical research 20090101
Involvement of PKC in TPA-potentiated apoptosis induction during hemin-mediated erythroid differentiation in K562 cells. Naunyn-Schmiedeberg's archives of pharmacology 20090101
Role of dosage-sensitive sex reversal, adrenal hypoplasia congenita, critical region on the X chromosome, gene 1 in protein kinase A- and protein kinase C-mediated regulation of the steroidogenic acute regulatory protein expression in mouse Leydig tumor cells: mechanism of action. Endocrinology 20090101
Extracellular hypotonicity induces disturbance of sodium currents in rat ventricular myocytes. Physiological research 20090101
Human antimicrobial protein hCAP18/LL-37 promotes a metastatic phenotype in breast cancer. Breast cancer research : BCR 20090101
Modulation of transient receptor potential Vanilloid 4-mediated membrane currents and synaptic transmission by protein kinase C. Molecular pain 20090101
Protein kinase C epsilon: an oncogene and emerging tumor biomarker. Molecular cancer 20090101
Effect of phorbol esters on the macrophage-mediated biodegradation of polyurethanes via protein kinase C activation and other pathways. Journal of biomaterials science. Polymer edition 20090101
Effect of inhibitors of mitogen-activated protein kinase kinase on alpha(1B)-adrenoceptor phosphorylation. Autonomic & autacoid pharmacology 20090101
Src, PKCalpha, and PKCdelta are required for alphavbeta3 integrin-mediated metastatic melanoma invasion. Cell communication and signaling : CCS 20090101
Protein kinase C activation disrupts epithelial apical junctions via ROCK-II dependent stimulation of actomyosin contractility. BMC cell biology 20090101
Thrombin induces Egr-1 expression in fibroblasts involving elevation of the intracellular Ca2+ concentration, phosphorylation of ERK and activation of ternary complex factor. BMC molecular biology 20090101
Wnt5a increases cardiac gene expressions of cultured human circulating progenitor cells via a PKC delta activation. PloS one 20090101
PKCepsilon-dependent potentiation of TTX-resistant Nav1.8 current by neurokinin-1 receptor activation in rat dorsal root ganglion neurons. Molecular pain 20090101
Signal transduction mechanisms underlying group I mGluR-mediated increase in frequency and amplitude of spontaneous EPSCs in the spinal trigeminal subnucleus oralis of the rat. Molecular pain 20090101
Infectivity of Leishmania mexicana is associated with differential expression of protein kinase C-like triggered during a cell-cell contact. PloS one 20090101
Diminished macrophage apoptosis and reactive oxygen species generation after phorbol ester stimulation in Crohn's disease. PloS one 20090101
Mechanism of ethanol-induced insulin secretion from INS-1 and INS-1E tumor cell lines. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20090101
Cathepsin G, a neutrophil protease, induces compact cell-cell adhesion in MCF-7 human breast cancer cells. Mediators of inflammation 20090101
MET/PKCbeta expression correlate with metastasis and inhibition is synergistic in lung cancer. Journal of carcinogenesis 20090101
YQ36: a novel bisindolylmaleimide analogue induces KB/VCR cell death. Journal of biomedicine & biotechnology 20090101
Protein kinase Cmu plays an essential role in hypertonicity-induced heat shock protein 70 expression. Experimental & molecular medicine 20081231
Exogenous nitric oxide-induced release of calcium from intracellular IP3 receptor-sensitive stores via S-nitrosylation in respiratory burst-dependent neutrophils. Biochemical and biophysical research communications 20081226
Search for inhibitors of bacterial and human protein kinases among derivatives of diazepines[1,4] annelated with maleimide and indole cycles. Journal of medicinal chemistry 20081225
Cholinergic excitation of dopaminergic cells depends on sequential activation of protein kinase C and the L-type calcium channel in ventral tegmental area slices. Brain research 20081215
L-leucine increases [3H]-thymidine incorporation in chicken hepatocytes: involvement of the PKC, PI3K/Akt, ERK1/2, and mTOR signaling pathways. Journal of cellular biochemistry 20081215
Bradykinin stimulates glutamate uptake via both B1R and B2R activation in a human retinal pigment epithelial cells. Life sciences 20081205
Dual regulation of the cardiac L-type calcium channel in L6 cells by protein kinase C. Cell calcium 20081201
Pharmacological evidence for the stimulation of NADPH oxidase by P2X(7) receptors in mouse submandibular glands. Purinergic signalling 20081201
Protein kinase C signaling in the hypothalamic arcuate nucleus regulates sexual receptivity in female rats. Endocrinology 20081201
Gonadotropin releasing hormone (GnRH) enhances annexin A5 mRNA expression through mitogen activated protein kinase (MAPK) in LbetaT2 pituitary gonadotrope cells. Endocrine journal 20081201
Ectodomain cleavage of the EGF ligands HB-EGF, neuregulin1-beta, and TGF-alpha is specifically triggered by different stimuli and involves different PKC isoenzymes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20081201
Fluoxetine-mediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation. Psychopharmacology 20081201
Phosphorylation of TRPV1 by neurokinin-1 receptor agonist exaggerates the capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons. Neuropharmacology 20081201
Effects of axotomy on cultured sensory neurons of Aplysia: long-term injury-induced changes in excitability and morphology are mediated by different signaling pathways. Journal of neurophysiology 20081201
Small-molecule inhibitors of PDK1. ChemMedChem 20081201
High glucose induces transactivation of the human paraoxonase 1 gene in hepatocytes. Metabolism: clinical and experimental 20081201
Simultaneous stimulation of spinal NK1 and NMDA receptors produces LPC which undergoes ATX-mediated conversion to LPA, an initiator of neuropathic pain. Journal of neurochemistry 20081201
Reciprocal influences of CB1 cannabinoid receptor agonists on ERK and JNK signalling in N1E-115 cells. FEBS letters 20081126
Design and synthesis of AX4697, a bisindolylmaleimide exo-affinity probe that labels protein kinase C alpha and beta. Bioorganic & medicinal chemistry letters 20081115
Protein kinase C-beta inhibition for diabetic kidney disease. Diabetes research and clinical practice 20081113
Nonclassical mechanisms of progesterone action in the brain: I. Protein kinase C activation in the hypothalamus of female rats. Endocrinology 20081101
Melatonin receptor-mediated protection against myocardial ischaemia/reperfusion injury: role of its anti-adrenergic actions. Journal of pineal research 20081101
Isoform-specific contribution of protein kinase C to prion processing. Molecular and cellular neurosciences 20081101
Substrate-induced changes in the density of peptide transporter PEPT1 expressed in Xenopus oocytes. American journal of physiology. Cell physiology 20081101
Electrogenic NBCe1 (SLC4A4), but not electroneutral NBCn1 (SLC4A7), cotransporter undergoes cholinergic-stimulated endocytosis in salivary ParC5 cells. American journal of physiology. Cell physiology 20081101
Protein kinase C-dependent and independent signaling pathways regulate synaptic GluR1 and GluR4 AMPAR subunits during in vitro classical conditioning. Neuroscience 20081028
Effects of phorbol ester on vesicle dynamics as revealed by total internal reflection fluorescence microscopy. Pflugers Archiv : European journal of physiology 20081001
Testosterone and dihydrotestosterone inhibit gallbladder motility through multiple signalling pathways. Steroids 20081001
Vasoactive intestinal peptide increases cystic fibrosis transmembrane conductance regulator levels in the apical membrane of Calu-3 cells through a protein kinase C-dependent mechanism. The Journal of pharmacology and experimental therapeutics 20081001
Dual orexin actions on dorsal raphe and laterodorsal tegmentum neurons: noisy cation current activation and selective enhancement of Ca2+ transients mediated by L-type calcium channels. Journal of neurophysiology 20081001
Calcium-sensing receptor signaling pathways in medullary thick ascending limb cells mediate COX-2-derived PGE2 production: functional significance. American journal of physiology. Renal physiology 20081001
A potential role of connexin 43 in epidermal growth factor-induced proliferation of mouse embryonic stem cells: involvement of Ca2+/PKC, p44/42 and p38 MAPKs pathways. Cell proliferation 20081001
Activity of protein kinase C is important for 3alpha,5alpha-THP's actions at dopamine type 1-like and/or GABAA receptors in the ventral tegmental area for lordosis of rats. Brain research bulletin 20080930
Muscarinic M(1) modulation of N and L types of calcium channels is mediated by protein kinase C in neostriatal neurons. Neuroscience 20080909
The heat shock protein antagonist 17-AAG potentiates the activity of enzastaurin against malignant human glioma cells. Cancer letters 20080908
Novel PKC signaling is required for LPS-induced soluble Flt-1 expression in macrophages. Journal of leukocyte biology 20080901
Attenuation of hypoosmotic stress-induced ANP secretion via I(Cl,swell) in renal hypertensive rat atria. Peptides 20080901
Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells. Carcinogenesis 20080901
Temporal correlation of the memory deficit with Alzheimer-like lesions induced by activation of glycogen synthase kinase-3. Journal of neurochemistry 20080901
Cellular and biochemical actions of melatonin which protect against free radicals: role in neurodegenerative disorders. Current neuropharmacology 20080901
PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival. International journal of cancer 20080815
Differential regulation of mTOR-dependent S6 phosphorylation by muscarinic acetylcholine receptor subtypes. Journal of cellular biochemistry 20080801
Kv 1.1 is associated with neuronal apoptosis and modulated by protein kinase C in the rat cerebellar granule cell. Journal of neurochemistry 20080801
Hypothalamic protein kinase C regulates glucose production. Diabetes 20080801
An immuno-chemo-proteomics method for drug target deconvolution. Journal of proteome research 20080801
Nonpeptidic antagonists of ETA and ETB receptors reverse the ET-1-induced sustained increase of cytosolic and nuclear calcium in human aortic vascular smooth muscle cells. Canadian journal of physiology and pharmacology 20080801
Protein kinase C-mediated protection of motoneurons from excitotoxicity. Neuroscience letters 20080711
G-protein-dependent and -independent pathways regulate proteinase-activated receptor-2 mediated p65 NFkappaB serine 536 phosphorylation in human keratinocytes. Cellular signalling 20080701
Phorbol ester-stimulated NF-kappaB-dependent transcription: roles for isoforms of novel protein kinase C. Cellular signalling 20080701
Signal transduction and transcriptional control of cardiac connexin43 up-regulation after alpha 1-adrenoceptor stimulation. The Journal of pharmacology and experimental therapeutics 20080701
Regulation of ERK1/2 by the C. elegans muscarinic acetylcholine receptor GAR-3 in Chinese hamster ovary cells. Molecules and cells 20080630
Pre-treatment with a PKC or PKA inhibitor prevents the development of morphine tolerance but not physical dependence in mice. Brain research 20080627
Kaempferol and quercetin stimulate granulocyte-macrophage colony-stimulating factor secretion in human prostate cancer cells. Molecular and cellular endocrinology 20080611
Differential effects of tumor necrosis factor-alpha and interleukin-1beta on cell death in human articular chondrocytes. Osteoarthritis and cartilage 20080601
17beta-estradiol attenuates glycogen synthase kinase-3beta activation and tau hyperphosphorylation in Akt-independent manner. Journal of neural transmission (Vienna, Austria : 1996) 20080601
Cysteinyl leukotriene-1 receptor activation in a human bronchial epithelial cell line leads to signal transducer and activator of transcription 1-mediated eosinophil adhesion. The Journal of pharmacology and experimental therapeutics 20080601
Apical adenosine regulates basolateral Ca2+-activated potassium channels in human airway Calu-3 epithelial cells. American journal of physiology. Cell physiology 20080601
Different kinases desensitize the human delta-opioid receptor (hDOP-R) in the neuroblastoma cell line SK-N-BE upon peptidic and alkaloid agonists. Cellular signalling 20080601
Coordinated phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 and protein kinase C betaII in the diabetic fat tissue. American journal of physiology. Endocrinology and metabolism 20080601
Modulation of cytokine production by plant sterols in stimulated human Jurkat T cells. Molecular nutrition & food research 20080601
Neurokinin 2 receptor-mediated activation of protein kinase C modulates capsaicin responses in DRG neurons from adult rats. The European journal of neuroscience 20080601
Protein kinase C protects from DNA damage-induced necrotic cell death by inhibiting poly(ADP-ribose) polymerase-1. FEBS letters 20080528
Links between enhanced fatty acid flux, protein kinase C and NFkappaB activation, and apoB-lipoprotein production in the fructose-fed hamster model of insulin resistance. Biochemical and biophysical research communications 20080523
Melatonin restores impaired contractility in aged guinea pig urinary bladder. Journal of pineal research 20080501
Inhibitory role of TGIF in the As2O3-regulated p21 WAF1/CIP1 expression. Journal of biomedical science 20080501
G(q)-dependent signalling by the lysophosphatidic acid receptor LPA(3) in gastric smooth muscle: reciprocal regulation of MYPT1 phosphorylation by Rho kinase and cAMP-independent PKA. The Biochemical journal 20080501
Prolactin stimulates transepithelial calcium transport and modulates paracellular permselectivity in Caco-2 monolayer: mediation by PKC and ROCK pathways. American journal of physiology. Cell physiology 20080501
Nicotinamide adenine dinucleotide phosphate (reduced form) oxidase is important for LPS-induced endothelial cell activation. Shock (Augusta, Ga.) 20080501
Inhibition of the rapid component of the delayed rectifier potassium current in ventricular myocytes by angiotensin II via the AT1 receptor. British journal of pharmacology 20080501
Vasopressin potentiates corticotropin-releasing hormone-induced insulin release from mouse pancreatic beta-cells. The Journal of endocrinology 20080501
Noncanonical Wnt11 signaling is sufficient to induce cardiomyogenic differentiation in unfractionated bone marrow mononuclear cells. Circulation 20080429
Down-regulation of caspase-2 by rottlerin via protein kinase C-delta-independent pathway. Cancer research 20080415
Protein kinase C inhibitors alter neurotensin receptor binding and function in prostate cancer PC3 cells. Regulatory peptides 20080410
Acute beta-amyloid administration disrupts the cholinergic control of dopamine release in the nucleus accumbens. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20080401
Positive signaling interactions between arsenic and ethanol for angiogenic gene induction in human microvascular endothelial cells. Toxicological sciences : an official journal of the Society of Toxicology 20080401
Rutaecarpine induces chloride secretion across rat isolated distal colon. The Journal of pharmacology and experimental therapeutics 20080401
Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages. American journal of physiology. Heart and circulatory physiology 20080401
Essential role of PKCdelta in histone deacetylase inhibitor-induced Epstein-Barr virus reactivation in nasopharyngeal carcinoma cells. The Journal of general virology 20080401
Bisindolylmaleimide IX facilitates extrinsic and initiates intrinsic apoptosis in TNF-alpha-resistant human colon adenocarcinoma COLO 205 cells. Apoptosis : an international journal on programmed cell death 20080401
Isoflurane preconditioning reduces the rat NR8383 macrophage injury induced by lipopolysaccharide and interferon gamma. Anesthesiology 20080401
Protein kinase C alpha modulates liver X receptor alpha transactivation. The Journal of endocrinology 20080401
P70 S6 kinase negatively regulates fibroblast growth factor 2-stimulated interleukin-6 synthesis in osteoblasts: function at a point downstream from protein kinase C. The Journal of endocrinology 20080401
Prostaglandin E2 and F2alpha activate the FP receptor and up-regulate cyclooxygenase-2 expression via the cyclic AMP response element. Molecular and cellular endocrinology 20080326
Protein kinase Cepsilon mediates polymeric fibronectin assembly on the surface of blood-borne rat breast cancer cells to promote pulmonary metastasis. The Journal of biological chemistry 20080321
Hypocretin-1 potentiates NMDA receptor-mediated somatodendritic secretion from locus ceruleus neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 20080319
Acetylcholine mediates the release of IL-8 in human bronchial epithelial cells by a NFkB/ERK-dependent mechanism. European journal of pharmacology 20080317
Rottlerin inhibits the nuclear factor kappaB/cyclin-D1 cascade in MCF-7 breast cancer cells. Life sciences 20080312
Participation of p38 MAPK and a novel-type protein kinase C in the control of mitochondrial Ca2+ uptake. Cell calcium 20080301
RACK1 regulates the cell surface expression of the G protein-coupled receptor for thromboxane A(2). Traffic (Copenhagen, Denmark) 20080301
Albumin-stimulated DNA synthesis is mediated by Ca2+/PKC as well as EGF receptor-dependent p44/42 MAPK and NF-kappaB signal pathways in renal proximal tubule cells. American journal of physiology. Renal physiology 20080301
Lipoxygenase metabolites are mediators of PTH-dependent human osteoblast growth. Bone 20080301
Alpha2-adrenoceptors enhance angiotensin II-induced renal vasoconstriction: role for NADPH oxidase and RhoA. Hypertension (Dallas, Tex. : 1979) 20080301
Bisindoylmaleimide I suppresses adipocyte differentiation through stabilization of intracellular beta-catenin protein. Biochemical and biophysical research communications 20080227
Evaluation of [3-(1-methyl-1H-indol-3-yl-methylene)-2-oxo-2, 3-dihydro-1H-indole-5-sulfonamide] (OXSI-2), as a Syk-selective inhibitor in platelets. European journal of pharmacology 20080212
PKC and MAPK signalling pathways regulate vascular endothelin receptor expression. European journal of pharmacology 20080202
CaR activation increases TNF production by mTAL cells via a Gi-dependent mechanism. American journal of physiology. Renal physiology 20080201
Endothelin-1 induction of Glut1 transcription in 3T3-L1 adipocytes involves distinct PKCepsilon- and p42/p44 MAPK-dependent pathways. Biochimica et biophysica acta 20080201
Probable involvement of epsilon-isoform of protein kinase C in rat bronchial smooth muscle contraction induced by acetylcholine. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20080201
Pertussis toxin B-oligomer suppresses human immunodeficiency virus-1 Tat-induced neuronal apoptosis through feedback inhibition of phospholipase C-beta by protein kinase C. Neuroscience 20080124
PI3-K- and PKC-dependent up-regulation of APP processing enzymes by retinoic acid. Biochemical and biophysical research communications 20080111
Mechanism of angiotensin II-induced superoxide production in cells reconstituted with angiotensin type 1 receptor and the components of NADPH oxidase. The Journal of biological chemistry 20080104
EGF-like peptides mediate FSH-induced maturation of cumulus cell-enclosed mouse oocytes. Molecular reproduction and development 20080101
Hypoxia induces epidermal keratinocyte matrix metalloproteinase-9 secretion via the protein kinase C pathway. Journal of cellular physiology 20080101
Role of protein kinase C isozymes in the regulation of alpha1-adrenergic receptor-mediated contractions in ovine uterine arteries. Biology of reproduction 20080101
Leukotriene D4 upregulates MUC2 gene transcription in human epithelial cells. Pharmacology 20080101
Opposite effect of phorbol ester PMA on PTGS2 and PGDH mRNA expression in human chorion trophoblast cells. Reproductive sciences (Thousand Oaks, Calif.) 20080101
Ca2+/calmodulin-dependent kinase kinase alpha is expressed by monocytic cells and regulates the activation profile. PloS one 20080101
Sphingosine can pre- and post-condition heart and utilizes a different mechanism from sphingosine 1-phosphate. Journal of biochemical and molecular toxicology 20080101
Galectin-1 upregulates glucose transporter-1 expression level via protein kinase C, phosphoinositol-3 kinase, and mammalian target of rapamycin pathways in mouse embryonic stem cells. The international journal of biochemistry & cell biology 20080101
PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior. Molecular pain 20080101
Bisindolylmaleimides in anti-cancer therapy - more than PKC inhibitors. Advances in medical sciences 20080101
ATP release from vascular endothelia occurs across Cx43 hemichannels and is attenuated during hypoxia. PloS one 20080101
Macropinocytosis is decreased in diabetic mouse macrophages and is regulated by AMPK. BMC immunology 20080101
Up-regulation of endothelin type B receptors in the human internal mammary artery in culture is dependent on protein kinase C and mitogen-activated kinase signaling pathways. BMC cardiovascular disorders 20080101
[Ca2+ -dependent modulation of antibiotic resistance in Streptomyces lividans 66 and Streptomyces coelicolor A3(2)]. Mikrobiologiia 20080101
Role of interleukin-6 in the control of DNA synthesis of hepatocytes: involvement of PKC, p44/42 MAPKs, and PPARdelta. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20080101
[The contribution of protein kinase C and Rho-kinase to the control of the receptor-dependent artery contraction decreases with age independently of sympathetic innervation]. Biofizika 20080101
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proceedings of the National Academy of Sciences of the United States of America 20071218
Continuous activation of G alpha q in osteoblasts results in osteopenia through impaired osteoblast differentiation. The Journal of biological chemistry 20071207
Rapid increase of glial glutamate uptake via blockade of the protein kinase A pathway. Glia 20071201
Rosiglitazone reduces glucose-induced oxidative stress mediated by NAD(P)H oxidase via AMPK-dependent mechanism. Arteriosclerosis, thrombosis, and vascular biology 20071201
Activation of protein kinase D1 in mast cells in response to innate, adaptive, and growth factor signals. Journal of immunology (Baltimore, Md. : 1950) 20071201
Activation of epidermal akt by diverse mouse skin tumor promoters. Molecular cancer research : MCR 20071201
Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits. The Journal of biological chemistry 20071109
Protein kinase C activity in the nucleus tractus solitarii is critically involved in the acute hypoxic ventilatory response, but is not required for intermittent hypoxia-induced phrenic long-term facilitation in adult rats. Experimental physiology 20071101
Effects of protein kinase C activation on cardiac repolarization and arrhythmogenesis in Langendorff-perfused rabbit hearts. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20071101
Effects of polychlorinated biphenyls (PCBs) on expression of neurotrophic factors in C6 glial cells in culture. Neurotoxicology 20071101
Lysophosphatidylcholine stimulates EGF receptor activation and mesangial cell proliferation: regulatory role of Src and PKC. Biochimica et biophysica acta 20071101
Effect of PAR1 agonist on acetylcholine secretion in a newly formed neuromuscular synapse in mice. Bulletin of experimental biology and medicine 20071101
RhoE participates in the stimulation of the inflammatory response induced by ethanol in astrocytes. Experimental cell research 20071015
Regulation of matrix Gla protein by parathyroid hormone in MC3T3-E1 osteoblast-like cells involves protein kinase A and extracellular signal-regulated kinase pathways. Journal of cellular biochemistry 20071001
Cytotoxic action of phorbol esters on human pancreatic cancer cells. International journal of cancer 20071001
P2Y nucleotide receptor signaling through MAPK/ERK is regulated by extracellular matrix: involvement of beta3 integrins. Journal of cellular physiology 20071001
Ceramide mediates inhibition of the renal epithelial sodium channel by tumor necrosis factor-alpha through protein kinase C. American journal of physiology. Renal physiology 20071001
Characterization of protein kinase pathways responsible for Ca2+ sensitization in rat ileal longitudinal smooth muscle. American journal of physiology. Gastrointestinal and liver physiology 20071001
Effect of phorbol ester and platelet-derived growth factor on protein kinase C in rat hepatic stellate cells. Liver international : official journal of the International Association for the Study of the Liver 20071001
Implication of PKC in the seasonal variation of the immune response of the hemocytes of Mytilus galloprovincialis Lmk. and its role in interleukin-2-induced nitric oxide synthesis. IUBMB life 20071001
Novel bisindolylmaleimide derivative inhibits mitochondrial permeability transition pore and protects the heart from reperfusion injury. Canadian journal of physiology and pharmacology 20071001
Phosphorylation of claudin-4 by PKCepsilon regulates tight junction barrier function in ovarian cancer cells. Experimental cell research 20070910
The anti-inflammatory activity of Phellinus linteus (Berk. & M.A. Curt.) is mediated through the PKCdelta/Nrf2/ARE signaling to up-regulation of heme oxygenase-1. Journal of ethnopharmacology 20070905
Regulation of plasminogen activators in human thyroid follicular cells and their relationship to differentiated function. Journal of cellular physiology 20070901
The role of protein kinase C isoenzymes in the regulation of calcineurin activity in human peripheral blood mononuclear cells. International journal of molecular medicine 20070901
In the ventral tegmental area, the membrane-mediated actions of progestins for lordosis of hormone-primed hamsters involve phospholipase C and protein kinase C. Journal of neuroendocrinology 20070901
Protein kinase C beta inhibition: the promise for treatment of diabetic nephropathy. Current opinion in nephrology and hypertension 20070901
In spermatozoa, Stat1 is activated during capacitation and the acrosomal reaction. Reproduction (Cambridge, England) 20070901
Characterization of noradrenaline-induced increases in intracellular Ca2+ levels in Chinese hamster ovary cells stably expressing human alpha1A-adrenoceptor. Journal of pharmacological sciences 20070901
Modulation of CCK-8-evoked intracellular Ca2+ waves by hydrogen peroxide in mouse pancreatic acinar cells. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20070901
Bisindolylmaleimides with large Stokes shift and long-lasting chemiluminescence properties. Organic letters 20070830
Mono-(2-ethylhexyl) phthalate (MEHP) induces nuclear receptor 4A subfamily in NCI-H295R cells: a possible mechanism of aromatase suppression by MEHP. Molecular and cellular endocrinology 20070815
Alpha1-adrenergic receptor stimulation induces the expression of receptor activator of nuclear factor kappaB ligand gene via protein kinase C and extracellular signal-regulated kinase pathways in MC3T3-E1 osteoblast-like cells. Archives of oral biology 20070801
Glycogen synthase kinase 3beta and beta-catenin are involved in the injury and repair of bronchial epithelial cells induced by scratching. Experimental and molecular pathology 20070801
Phosphorylation of the Aspergillus oryzae Woronin body protein, AoHex1, by protein kinase C: evidence for its role in the multimerization and proper localization of the Woronin body protein. The Biochemical journal 20070801
Angiotensin II inhibits native bTREK-1 K+ channels through a PLC-, kinase C-, and PIP2-independent pathway requiring ATP hydrolysis. American journal of physiology. Cell physiology 20070801
Evidence for an important role of protein phosphatases in the mechanism of morphine tolerance. Brain research 20070723
Mechanism of membrane redistribution of protein kinase C by its ATP-competitive inhibitors. The Biochemical journal 20070715
The protein kinase C pathway mediates cardioprotection induced by cardiac-specific overexpression of fibroblast growth factor-2. American journal of physiology. Heart and circulatory physiology 20070701
Insulin-like growth factor-I induces cyclooxygenase-2 expression via PI3K, MAPK and PKC signaling pathways in human ovarian cancer cells. Cellular signalling 20070701
Decrease in N-methyl-D-aspartic acid receptor-NR2B subunit levels by intrathecal short-hairpin RNA blocks group I metabotropic glutamate receptor-mediated hyperalgesia. The Journal of pharmacology and experimental therapeutics 20070701
IGF-I inhibition of apoptosis is associated with decreased expression of prostate apoptosis response-4. The Journal of endocrinology 20070701
Protein kinase C modulates the phase-delaying effects of light in the mammalian circadian clock. The European journal of neuroscience 20070701
A novel bisindolylmaleimide derivative enhances functional recovery of heart after long-term hypothermic heart preservation. Transplantation 20070627
NMDA receptor-mediated extracellular adenosine accumulation is blocked by phosphatase 1/2A inhibitors. Brain research 20070625
Transcriptional regulation of follistatin expression by GnRH in mouse gonadotroph cell lines: evidence for a role for cAMP signaling. Molecular and cellular endocrinology 20070615
Induction of cyclooxygenase-2 expression by manganese in cultured astrocytes. Neurochemistry international 20070601
Protein kinase C inhibition attenuates hypochlorite-induced acute lung injury. Respiratory medicine 20070601
Regulation of PDGF-stimulated SHIP2 tyrosine phosphorylation and association with Shc in 3T3-L1 preadipocytes. Journal of cellular physiology 20070601
Role of L-type calcium channels and PKC in active tone development in rabbit coronary artery. American journal of physiology. Heart and circulatory physiology 20070601
Protein kinase Calpha mediates feedback inhibition of EGF receptor transactivation induced by Gq-coupled receptor agonists. Cellular signalling 20070601
A PKC-Sp1 signaling pathway induces early differentiation of human keratinocytes through upregulation of TSG101. Cellular signalling 20070601
Activation of classical protein kinase C decreases transport via systems y+ and y+L. American journal of physiology. Cell physiology 20070601
Adrenergic control of a constitutively active acetylcholine-regulated potassium current in canine atrial cardiomyocytes. Cardiovascular research 20070601
Modulation of hERG potassium currents in HEK-293 cells by protein kinase C. Evidence for direct phosphorylation of pore forming subunits. The Journal of physiology 20070601
Potentiation of glutamatergic synaptic transmission by protein kinase C-mediated sensitization of TRPV1 at the first sensory synapse. The Journal of physiology 20070601
Cellular regulation of basal tone in internal anal sphincter smooth muscle by RhoA/ROCK. American journal of physiology. Gastrointestinal and liver physiology 20070601
Structure based de novo design of novel glycogen synthase kinase 3 inhibitors. Bioorganic & medicinal chemistry 20070601
Dehydroevodiamine attenuates tau hyperphosphorylation and spatial memory deficit induced by activation of glycogen synthase kinase-3 in rats. Neuropharmacology 20070601
Homologous desensitization of signalling by the alpha (alpha) isoform of the human thromboxane A2 receptor: a specific role for nitric oxide signalling. Biochimica et biophysica acta 20070601
Downregulation of the reduced folate carrier transport activity by phenobarbital-type cytochrome P450 inducers and protein kinase C activators. Biochimica et biophysica acta 20070601
Inhibition of ABCG2-mediated transport by protein kinase inhibitors with a bisindolylmaleimide or indolocarbazole structure. Molecular cancer therapeutics 20070601
Protein kinase C-mediated phosphorylation of the calcium-sensing receptor is stimulated by receptor activation and attenuated by calyculin-sensitive phosphatase activity. The Journal of biological chemistry 20070518
ERK-dependent and -independent pathways trigger human neural progenitor cell migration. Toxicology and applied pharmacology 20070515
Protein Kinase C- alpha/betaII, delta, and zeta/lambda involvement in ethanol-induced MAPK expression in vascular smooth muscle cells. Cellular and molecular biology (Noisy-le-Grand, France) 20070515
Involvement of nPKC-MAPK pathway in the decrease of nucleophosmin/B23 during megakaryocytic differentiation of human myelogenous leukemia K562 cells. Life sciences 20070508
The inhibitory mechanism of methylmercury on differentiation of human neuroblastoma cells. Toxicology 20070505
Dopamine stimulates 45Ca2+ uptake through cAMP, PLC/PKC, and MAPKs in renal proximal tubule cells. Journal of cellular physiology 20070501
Inhibitory effect of TNF-alpha on the intestinal absorption of galactose. Journal of cellular biochemistry 20070501
The role of proline-rich protein tyrosine kinase 2 in differentiation-dependent signaling in human epidermal keratinocytes. The Journal of investigative dermatology 20070501
Sphingosylphosphorylcholine-induced interleukin-6 production is mediated by protein kinase C and p42/44 extracellular signal-regulated kinase in human dermal fibroblasts. Journal of dermatological science 20070501
Neurokinins enhance excitability in capsaicin-responsive DRG neurons. Experimental neurology 20070501
[Low extracellular pH increases the persistent sodium current in guinea pig ventricular myocytes]. Sheng li xue bao : [Acta physiologica Sinica] 20070425
The PKC inhibitor, bisindolymaleimide, blocks DOI's attenuation of the effects of 8-OH-DPAT on female rat lordosis behavior. Behavioural brain research 20070416
A novel cyathane diterpene, cyrneine A, induces neurite outgrowth in a Rac1-dependent mechanism in PC12 cells. Life sciences 20070410
Oxysterol-induced osteoblastic differentiation of pluripotent mesenchymal cells is mediated through a PKC- and PKA-dependent pathway. Journal of cellular biochemistry 20070401
Alpha1-adrenergic stress induces downregulation of Na+/Ca2+ exchanger in myocardial preparations from rabbits at physiological preload. European journal of heart failure 20070401
Phosphoinositide-3-kinase and mitogen activated protein kinase signaling pathways mediate acute NGF sensitization of TRPV1. Molecular and cellular neurosciences 20070401
Stimulatory action of protein kinase C(epsilon) isoform on the slow component of delayed rectifier K+ current in guinea-pig atrial myocytes. British journal of pharmacology 20070401
Melatonin induces neuritogenesis at early stages in N1E-115 cells through actin rearrangements via activation of protein kinase C and Rho-associated kinase. Journal of pineal research 20070401
Nitric oxide synthase inhibitors modulate nerve growth factor-mediated regulation of amyloid precursor protein expression in PC12 cells. Journal of neurochemistry 20070401
Increased leukocyte adhesion to vascular endothelium in preeclampsia is inhibited by antioxidants. American journal of obstetrics and gynecology 20070401
Signaling mechanisms leading to regulation of proliferation and differentiation of the mesenchymal chondrogenic cell line RCJ3.1C5.18 in response to IGF-I. Journal of molecular endocrinology 20070401
Protein kinase C activity mediates LH-induced ErbB/Erk signaling in differentiated hen granulosa cells. Reproduction (Cambridge, England) 20070401
Glucose down-regulation of cGMP-dependent protein kinase I expression in vascular smooth muscle cells involves NAD(P)H oxidase-derived reactive oxygen species. Free radical biology & medicine 20070315
Repeated cocaine administration impairs group II metabotropic glutamate receptor-mediated long-term depression in rat medial prefrontal cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience 20070314
Bradykinin-induced chloride conductance in murine proximal tubule epithelial cells. Molecular and cellular biochemistry 20070301
Role of ROS and MAPK in TPA-induced ICAM-1 expression in the myeloid ML-1 cell line. Journal of cellular biochemistry 20070301
Role of atypical protein kinase C isozymes and NF-kappaB in IL-1beta-induced expression of cyclooxygenase-2 in human myometrial smooth muscle cells. Journal of cellular physiology 20070301
PKC delta-isoform translocation and enhancement of tonic contractions of gastrointestinal smooth muscle. American journal of physiology. Gastrointestinal and liver physiology 20070301
Cross-regulation of VPAC(2) receptor desensitization by M(3) receptors via PKC-mediated phosphorylation of RKIP and inhibition of GRK2. American journal of physiology. Gastrointestinal and liver physiology 20070301
Role of nuclear factor-kappaB and protein kinase C signaling in the expression of the kinin B1 receptor in human vascular smooth muscle cells. Molecular pharmacology 20070301
Phosphatidylinositol 3'-kinase is a critical mediator of interferon-gamma-induced increases in enteric epithelial permeability. The Journal of pharmacology and experimental therapeutics 20070301
Sustained activation of proton channels and NADPH oxidase in human eosinophils and murine granulocytes requires PKC but not cPLA2 alpha activity. The Journal of physiology 20070301
Gonadotropin-releasing hormone couples to 3',5'-cyclic adenosine-5'-monophosphate pathway through novel protein kinase Cdelta and -epsilon in LbetaT2 gonadotrope cells. Endocrinology 20070301
Acetylcholine activates protein kinase C-alpha in pulmonary venous smooth muscle. Anesthesiology 20070301
Propionate induces pH(i) changes through calcium flux, ERK1/2, p38, and PKC in bovine neutrophils. Veterinary immunology and immunopathology 20070215
Bisindolylmaleimide I suppresses fibroblast growth factor-mediated activation of Erk MAP kinase in chondrocytes by preventing Shp2 association with the Frs2 and Gab1 adaptor proteins. The Journal of biological chemistry 20070202
Restoration of diabetes-induced abnormal local Ca2+ release in cardiomyocytes by angiotensin II receptor blockade. American journal of physiology. Heart and circulatory physiology 20070201
Stimulation of adenosine A1 and A2A receptors by AMP in the submucosal plexus of guinea pig small intestine. American journal of physiology. Gastrointestinal and liver physiology 20070201
17beta-estradiol antagonizes the down-regulation of endothelial nitric-oxide synthase and GTP cyclohydrolase I by high glucose: relevance to postmenopausal diabetic cardiovascular disease. The Journal of pharmacology and experimental therapeutics 20070201
Propofol modulates Na+-Ca2+ exchange activity via activation of protein kinase C in diabetic cardiomyocytes. Anesthesiology 20070201
Anti-apoptotic effect of retinoic acid on retinal progenitor cells mediated by a protein kinase A-dependent mechanism. Cell research 20070201
Chemically diverse toxicants converge on Fyn and c-Cbl to disrupt precursor cell function. PLoS biology 20070201
Effects of calmodulin and protein kinase C modulators on transient Ca2+ increase and capacitative Ca2+ entry in human platelets: relevant to pathophysiology of bipolar disorder. Progress in neuro-psychopharmacology & biological psychiatry 20070130
Differential regulation of CREB and ERK phosphorylation through corticotropin-releasing factor receptors type 1 and 2 in AtT-20 and A7r5 cells. Molecular and cellular endocrinology 20070115
Phospholipase A2-independent Ca2+ entry and subsequent apoptosis induced by melittin in human MG63 osteosarcoma cells. Life sciences 20070102
Dual mechanism of autoregulation of protein kinase C in myocardial ischemia. Molecular and cellular biochemistry 20070101
Mitogen activated protein kinase and protein kinase C activation mediate promotion of sAPPalpha secretion by deprenyl. Neurochemistry international 20070101
Angiotensin II-induced MAPK phosphorylation mediated by Ras and/or phospholipase C-dependent phosphorylations but not by protein kinase C phosphorylation in cultured rat vascular smooth muscle cells. Pharmacology 20070101
Phospholipase C gamma negatively regulates Rac/Cdc42 activation in antigen-stimulated mast cells. European journal of immunology 20070101
Selective protein kinase C inhibition attenuates pulmonary artery cytokine expression without affecting hypoxic pulmonary vasoconstriction. Shock (Augusta, Ga.) 20070101
Propofol increases pulmonary vascular resistance during alpha-adrenoreceptor activation in normal and monocrotaline-induced pulmonary hypertensive rats. Anesthesia and analgesia 20070101
Matrix metalloproteinase-9 is differentially expressed in nonfunctioning invasive and noninvasive pituitary adenomas and increases invasion in human pituitary adenoma cell line. The American journal of pathology 20070101
Stimulation of fibroblast proliferation by neokyotorphin requires Ca influx and activation of PKA, CaMK II and MAPK/ERK. The FEBS journal 20070101
Signalling pathways involved in the control of sperm cell volume. Reproduction (Cambridge, England) 20070101
Effects of valproate on serotonin-induced intracellular calcium mobilization in human platelets. Journal of psychiatry & neuroscience : JPN 20070101
Iloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungs. Respiratory research 20070101
Role of protein kinase C in substance P-induced synaptic depression in the nucleus accumbens in vitro. Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20070101
Chemical combination effects predict connectivity in biological systems. Molecular systems biology 20070101
Ruboxistaurin: LY 333531. Drugs in R&D 20070101
Involvement of glycogen synthase kinase-3beta in palmitate-induced human umbilical vein endothelial cell apoptosis. Journal of vascular research 20070101
Endothelin potentiates TRPV1 via ETA receptor-mediated activation of protein kinase C. Molecular pain 20070101
Carbachol-mediated pigment granule dispersion in retinal pigment epithelium requires Ca2+ and calcineurin. BMC cell biology 20070101
Activation of the neurokinin-1 receptor by substance P triggers the release of substance P from cultured adult rat dorsal root ganglion neurons. Molecular pain 20070101
Annual scientific meeting, edmonton, september 27-30, 2007. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20070101
TNF-alpha decreases hsp 27 in human blood mononuclear cells: involvement of protein kinase c. Life sciences 20061223
Mechanisms of glutamate receptor induced proliferation of astrocytes. Neuroreport 20061218
Effect of EGF on [3H]-thymidine incorporation and cell cycle regulatory proteins in primary cultured chicken hepatocytes: Involvement of Ca2+/PKC and MAPKs. Journal of cellular biochemistry 20061215
Regulation of the cardiac L-type calcium channel in L6 cells by arginine-vasopressin. The Biochemical journal 20061215
Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition. Journal of medicinal chemistry 20061214
Intracellular messengers involved in spontaneous pain, heat hyperalgesia, and mechanical allodynia induced by intrathecal dihydroxyphenylglycine. Neuroscience letters 20061206
[Phosphorylation of PKCdelta participates in the toxicity of 6-hydroxydopamine on dopaminergic neuroblastoma cell]. Zhonghua yi xue za zhi 20061205
Decrease in density of INa is in the common final pathway to heart block in murine hearts overexpressing calcineurin. American journal of physiology. Heart and circulatory physiology 20061201
Signal pathways involved in the regulation of prostaglandin E synthase-1 in human gingival fibroblasts. Cellular signalling 20061201
ATP stimulates mouse embryonic stem cell proliferation via protein kinase C, phosphatidylinositol 3-kinase/Akt, and mitogen-activated protein kinase signaling pathways. Stem cells (Dayton, Ohio) 20061201
PKC and PKA inhibitors reinstate morphine-induced behaviors in morphine tolerant mice. Pharmacological research 20061201
Control of oestradiol secretion and of cytochrome P450 aromatase messenger ribonucleic acid accumulation by FSH involves different intracellular pathways in oestrogenic bovine granulosa cells in vitro. Reproduction (Cambridge, England) 20061201
Beta-1, 3-glucan modulates PKC signalling in Lymnaea stagnalis defence cells: a role for PKC in H2O2 production and downstream ERK activation. The Journal of experimental biology 20061201
Angiotensin II does not stimulate proliferation of rat thyroid PC Cl3 cell line. The Journal of endocrinology 20061201
Effects of (+)-eudesmin from the stem bark of magnolia kobus DC. var. borealis Sarg. on neurite outgrowth in PC12 cells. Archives of pharmacal research 20061201
Structure of the catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor. Biochemistry 20061128
Nitric oxide produced in response to engagement of beta2 integrins on human neutrophils activates the monomeric GTPases Rap1 and Rap2 and promotes adhesion. The Journal of biological chemistry 20061117
Nucleotide regulation of the voltage-dependent nonselective cation conductance in murine colonic myocytes. American journal of physiology. Cell physiology 20061101
PAR-2 agonists activate trigeminal nociceptors and induce functional competence in the delta opioid receptor. Pain 20061101
Ras triggers acidosis-induced activation of the extracellular-signal-regulated kinase pathway in cardiac myocytes. The Biochemical journal 20061101
Enhanced thromboxane receptor-mediated responses and impaired endothelium-dependent relaxation in human corpus cavernosum from diabetic impotent men: role of protein kinase C activity. The Journal of pharmacology and experimental therapeutics 20061101
Phorbol ester potentiates the growth inhibitory effects of troglitazone via up-regulation of PPARgamma in A549 cells. Biochemical and biophysical research communications 20061020
A practical method for the synthesis of indolylaryl- and bisindolylmaleimides. Organic letters 20061012
Mechanism of inhibition of TREK-2 (K2P10.1) by the Gq-coupled M3 muscarinic receptor. American journal of physiology. Cell physiology 20061001
EGF-induced inhibition of glucose transport is mediated by PKC and MAPK signal pathways in primary cultured chicken hepatocytes. American journal of physiology. Gastrointestinal and liver physiology 20061001
Sphingosine 1-phosphate affects cytokine-induced apoptosis in rat pancreatic islet beta-cells. Endocrinology 20061001
Role of kinases and G-proteins in the hyposmotic stimulation of cardiac IKs. Biochimica et biophysica acta 20061001
Protein kinase Cbeta isoform down-regulates the expression of MDR3 P-glycoprotein in human Chang liver cells. Biochimica et biophysica acta 20061001
5-HT evokes sensory long-term facilitation of rodent carotid body via activation of NADPH oxidase. The Journal of physiology 20061001
Propofol inhibits phorbol 12, 13-dibutyrate-induced, protein kinase C-mediated contraction of rat aortic smooth muscle. Acta anaesthesiologica Scandinavica 20061001
Reactive oxygen species mediated sustained activation of protein kinase C alpha and extracellular signal-regulated kinase for migration of human hepatoma cell Hepg2. Molecular cancer research : MCR 20061001
Glucagon-like peptide 1 activates protein kinase C through Ca2+-dependent activation of phospholipase C in insulin-secreting cells. The Journal of biological chemistry 20060929
Modulation of mitochondrial metabolic function by phorbol 12-myristate 13-acetate through increased mitochondrial translocation of protein kinase Calpha in C2C12 myocytes. Biochemical pharmacology 20060928
Hydrogen peroxide-induced arachidonic acid release in L929 cells; roles of Src, protein kinase C and cytosolic phospholipase A2alpha. European journal of pharmacology 20060928
Role of store-operated calcium channels and calcium sensitization in normoxic contraction of the ductus arteriosus. Circulation 20060926
Curcumin inhibits neurotensin-mediated interleukin-8 production and migration of HCT116 human colon cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research 20060915
Synthesis of bisindolylmaleimides related to GF109203x and their efficient conversion to the bioactive indolocarbazoles. Organic & biomolecular chemistry 20060907
Calcium channel and glutamate receptor activities regulate actin organization in salamander retinal neurons. The Journal of physiology 20060901
Increase of C-type natriuretic peptide expression by serum and platelet-derived growth factor-BB in human aortic smooth muscle cells is dependent on protein kinase C activation. Endocrinology 20060901
A cyclic adenosine 3',5'-monophosphate-dependent protein kinase C activation is involved in the hyperactivation of boar spermatozoa. Molecular reproduction and development 20060901
Nox2, Ca2+, and protein kinase C play a role in angiotensin II-induced free radical production in nucleus tractus solitarius. Hypertension (Dallas, Tex. : 1979) 20060901
Homologous desensitization of signalling by the beta (beta) isoform of the human thromboxane A2 receptor. Biochimica et biophysica acta 20060901
The sarcoplasmic-endoplasmic reticulum Ca2+ ATPase 2b regulates the Ca2+ transients elicited by P2Y2 activation in PC Cl3 thyroid cells. The Journal of endocrinology 20060901
Histamine induces interleukin-6 expression in the human synovial sarcoma cell line (SW982) through the H1 receptor. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20060901
Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes. The Journal of biological chemistry 20060825
Oleate-induced decrease in hepatocyte insulin binding is mediated by PKC-delta. Biochemical and biophysical research communications 20060804
P2Y12 receptor signalling towards PKB proceeds through IGF-I receptor cross-talk and requires activation of Src, Pyk2 and Rap1. Cellular signalling 20060801
Pharmacological and molecular characterization of the mechanisms involved in prostaglandin E2-induced mouse paw edema. The Journal of pharmacology and experimental therapeutics 20060801
Agonist-selective mechanisms of mu-opioid receptor desensitization in human embryonic kidney 293 cells. Molecular pharmacology 20060801
Dopamine regulates cell cycle regulatory proteins via cAMP, Ca(2+)/PKC, MAPKs, and NF-kappaB in mouse embryonic stem cells. Journal of cellular physiology 20060801
On the mechanisms of 12-O-tetradecanoylphorbol-13-acetate-induced growth arrest in pancreatic cancer cells. Pancreas 20060801
Activation of extracellular signal-regulated kinase (ERK) in G2 phase delays mitotic entry through p21CIP1. Cell proliferation 20060801
Phosphorylation of dystrophin Dp71d by Ca2+/calmodulin-dependent protein kinase II modulates the Dp71d nuclear localization in PC12 cells. Journal of neurochemistry 20060801
The regulatory mechanism by which interleukin-6 stimulates GH-gene expression in rat GH3 cells. The Journal of endocrinology 20060801
Role of the sodium-dependent phosphate co-transporters and of the phosphate complexes of uranyl in the cytotoxicity of uranium in LLC-PK1 cells. Toxicology and applied pharmacology 20060715
Protein tyrosine kinase and p38 MAP kinase pathways are involved in stimulation of matrix metalloproteinase-9 by TNF-alpha in human monocytes. Immunology letters 20060715
Mechanosensitive synoviocytes: a Ca2+ -PKCalpha-MAP kinase pathway contributes to stretch-induced hyaluronan synthesis in vitro. Matrix biology : journal of the International Society for Matrix Biology 20060701
Neurotrophic factor production in human astrocytoma cells by 2,5,6-tribromogramine via activation of epsilon isoform of protein kinase C. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060701
Norepinephrine-induced changes in gene expression of phospholipase C in cardiomyocytes. Journal of molecular and cellular cardiology 20060701
ATP stimulates interleukin-6 production via P2Y receptors in human HaCaT keratinocytes. European journal of pharmacology 20060701
Enzastaurin (LY317615), a protein kinase Cbeta inhibitor, inhibits the AKT pathway and induces apoptosis in multiple myeloma cell lines. Molecular cancer therapeutics 20060701
Neuronal mechanisms of active (rapid eye movement) sleep induced by microinjections of hypocretin into the nucleus pontis oralis of the cat. Neuroscience 20060619
Stimulation of cyclic AMP production by the Caenorhabditis elegans muscarinic acetylcholine receptor GAR-3 in Chinese hamster ovary cells. Archives of biochemistry and biophysics 20060615
Oxidative stress and Mrp2 internalization. Free radical biology & medicine 20060615
Muscle cell depolarization induces a gain in surface GLUT4 via reduced endocytosis independently of AMPK. American journal of physiology. Endocrinology and metabolism 20060601
The shedding of syndecan-4 and syndecan-1 from HeLa cells and human primary macrophages is accelerated by SDF-1/CXCL12 and mediated by the matrix metalloproteinase-9. Glycobiology 20060601
Apelin stimulates myosin light chain phosphorylation in vascular smooth muscle cells. Arteriosclerosis, thrombosis, and vascular biology 20060601
Tyrosine kinase and phosphatase regulation of slow delayed-rectifier K+ current in guinea-pig ventricular myocytes. The Journal of physiology 20060601
Mechanical hyperalgesia induced by endothelin-1 in rats is mediated via phospholipase C, protein kinase C, and MAP kinases. Experimental biology and medicine (Maywood, N.J.) 20060601
Proinsulin C-peptide stimulates a PKC/IkappaB/NF-kappaB signaling pathway to activate COX-2 gene transcription in Swiss 3T3 fibroblasts. Journal of biochemistry 20060601
Bryostatin enhancement of memory in Hermissenda. The Biological bulletin 20060601
Roles of Ca2+ and protein kinase C in the excitatory response to serotonin in embryonic molluscan ciliary cells. Canadian journal of physiology and pharmacology 20060601
Adiponectin stimulates proliferation and cytokine secretion in colonic epithelial cells. Regulatory peptides 20060515
Optimal Sox-based fluorescent chemosensor design for serine/threonine protein kinases. Analytical biochemistry 20060515
N-(4-hydroxyphenyl)retinamide-induced apoptosis triggered by reactive oxygen species is mediated by activation of MAPKs in head and neck squamous carcinoma cells. Oncogene 20060504
Human melanocortin receptor 2 expression and functionality: effects of protein kinase A and protein kinase C on desensitization and internalization. Endocrinology 20060501
Adenosine A1 receptor-mediated inhibition of myocardial norepinephrine release involves neither phospholipase C nor protein kinase C but does involve adenylyl cyclase. Canadian journal of physiology and pharmacology 20060501
Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation. The Journal of biological chemistry 20060421
Effect of protein kinase C inhibitors on porcine oocyte activation. Journal of experimental zoology. Part A, Comparative experimental biology 20060401
Involvement of protein kinase Cdelta in the activation of NADPH oxidase and the phagocytosis of neutrophils. Free radical research 20060401
Regulation of vascular smooth muscle proliferation and migration by beta2-chimaerin, a non-protein kinase C phorbol ester receptor. International journal of molecular medicine 20060401
Infection of HEp2 epithelial cells with Candida albicans: adherence and postadherence events. FEMS immunology and medical microbiology 20060401
Atypical PKCzeta is involved in RhoA-dependent mitogenic signaling by the P2Y(12) receptor in C6 cells. The FEBS journal 20060401
Regulation of protein kinase C delta by phorbol ester, endothelin-1, and platelet-derived growth factor in cardiac myocytes. The Journal of biological chemistry 20060331
Sigma2 (sigma2) receptors as a target for cocaine action in the rat striatum. European journal of pharmacology 20060327
hTERT phosphorylation by PKC is essential for telomerase holoprotein integrity and enzyme activity in head neck cancer cells. British journal of cancer 20060327
Bradykinin augments EGF-induced airway smooth muscle proliferation by activation of conventional protein kinase C isoenzymes. European journal of pharmacology 20060327
Oncostatin M induces cell detachment and enhances the metastatic capacity of T-47D human breast carcinoma cells. Cytokine 20060321
Activation of P2Y1 receptor triggers two calcium signaling pathways in bone marrow erythroblasts. European journal of pharmacology 20060318
Angiotensin II potentiates the slow component of delayed rectifier K+ current via the AT1 receptor in guinea pig atrial myocytes. Circulation 20060314
Glycated proteins stimulate reactive oxygen species production in cardiac myocytes: involvement of Nox2 (gp91phox)-containing NADPH oxidase. Circulation 20060307
Identification of the insulin signaling cascade in the regulation of alpha-class glutathione S-transferase expression in primary cultured rat hepatocytes. The Journal of pharmacology and experimental therapeutics 20060301
Tumor necrosis factor-alpha activates the extrapituitary PRL promoter in myeloid leukemic cells. Journal of neuroimmunology 20060301
High glucose-induced inhibition of 2-deoxyglucose uptake is mediated by cAMP, protein kinase C, oxidative stress and mitogen-activated protein kinases in mouse embryonic stem cells. Clinical and experimental pharmacology & physiology 20060301
Mechanism of gonadotropin-releasing hormone (GnRH)-I and -II-induced cell growth inhibition in ovarian cancer cells: role of the GnRH-I receptor and protein kinase C pathway. Endocrine-related cancer 20060301
Protein kinase C cross-talk with gonadotrope progesterone receptor is involved in GnRH-induced LH secretion. Journal of physiology and biochemistry 20060301
Mitogen-activated protein kinases control cardiac KChIP2 gene expression. Circulation research 20060217
Neuroendocrine protein 7B2 can be inactivated by phosphorylation within the secretory pathway. The Journal of biological chemistry 20060210
Protein kinase C negatively regulates Akt activity and modifies UVC-induced apoptosis in mouse keratinocytes. The Journal of biological chemistry 20060210
Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats. American journal of physiology. Lung cellular and molecular physiology 20060201
Effects of tyrosine phosphorylation of cortactin on podosome formation in A7r5 vascular smooth muscle cells. American journal of physiology. Cell physiology 20060201
Involvement of protein kinase C in crystalline silica-induced activation of the MAP kinase and AP-1 pathway. American journal of physiology. Lung cellular and molecular physiology 20060201
Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways. Journal of cellular biochemistry 20060201
Elucidation of ATP-stimulated stress protein expression of RBA-2 type-2 astrocytes: ATP potentiate HSP60 and Cu/Zn SOD expression and stimulates pI shift of peroxiredoxin II. Journal of cellular biochemistry 20060201
Ceramide decreases surfactant protein B gene expression via downregulation of TTF-1 DNA binding activity. American journal of physiology. Lung cellular and molecular physiology 20060201
Role of hydrogen sulfide in the cardioprotection caused by ischemic preconditioning in the rat heart and cardiac myocytes. The Journal of pharmacology and experimental therapeutics 20060201
Assembly of tight junction is regulated by the antagonism of conventional and novel protein kinase C isoforms. The international journal of biochemistry & cell biology 20060201
Nonclassical action of retinoic acid on the activation of the cAMP response element-binding protein in normal human bronchial epithelial cells. Molecular biology of the cell 20060201
Endothelin-1 enhances capsaicin-evoked intracellular Ca2+ response via activation of endothelin a receptor in a protein kinase Cepsilon-dependent manner in dorsal root ganglion neurons. Neuroscience 20060201
Role of PKC isoforms in the Fc(gamma)R-mediated inhibition of LPS-stimulated IL-12 secretion by macrophages. Journal of leukocyte biology 20060201
Up-regulation of CPI-17 phosphorylation in diabetic vasculature and high glucose cultured vascular smooth muscle cells. Cardiovascular research 20060201
Subchronic alpha- and beta-adrenergic regulation of cardiac gap junction protein expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060201
Reactive oxygen species mediate shear stress-induced fluid-phase endocytosis in vascular endothelial cells. Free radical research 20060201
Insulin-regulated aminopeptidase marks an antigen-stimulated recycling compartment in mast cells. Traffic (Copenhagen, Denmark) 20060201
The neuropeptide proctolin potentiates contractions and reduces cGMP concentration via a PKC-dependent pathway. The Journal of experimental biology 20060201
Involvement of reduced sensitivity to Ca in beta-adrenergic action on airway smooth muscle. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20060201
Novel protein kinase C-epsilon inhibits human CYP11B2 gene expression through ERK1/2 signalling pathway and JunB. Journal of molecular endocrinology 20060201
Involvement of arachidonic acid metabolism and EGF receptor in neurotensin-induced prostate cancer PC3 cell growth. Regulatory peptides 20060115
G-protein-coupled OX1 orexin/hcrtr-1 hypocretin receptors induce caspase-dependent and -independent cell death through p38 mitogen-/stress-activated protein kinase. The Journal of biological chemistry 20060113
Peroxynitrite-induced mitochondrial translocation of PKCalpha causes U937 cell survival. Biochemical and biophysical research communications 20060106
PKCalpha reduces the lipid kinase activity of the p110alpha/p85alpha PI3K through the phosphorylation of the catalytic subunit. Biochemical and biophysical research communications 20060106
Protein kinase C potentiates homologous desensitization of the beta2-adrenoceptor in bovine tracheal smooth muscle. European journal of pharmacology 20060104
EGF stimulates proliferation of mouse embryonic stem cells: involvement of Ca2+ influx and p44/42 MAPKs. American journal of physiology. Cell physiology 20060101
Tyrosine kinase and mitogen-activated protein kinase/extracellularly regulated kinase differentially regulate intracellular calcium concentration responses to angiotensin II/III and bradykinin in rat cortical thick ascending limb. Endocrinology 20060101
Evidence that protease-activated receptor-2 mediates trypsin-induced reversal of stellation in cultured rat astrocytes. Neuroscience research 20060101
Sustained activation of metabotropic glutamate receptor 5 and protein tyrosine phosphatases mediate the expression of (S)-3,5-dihydroxyphenylglycine-induced long-term depression in the hippocampal CA1 region. Journal of neurochemistry 20060101
Protein kinase C (PKC)-delta/-epsilon mediate the PKC/Akt-dependent phosphorylation of extracellular signal-regulated kinases 1 and 2 in MCF-7 cells stimulated by bradykinin. The Journal of endocrinology 20060101
The induction of CCN2 by TGFbeta1 involves Ets-1. Arthritis research & therapy 20060101
Methylglyoxal downregulates Raf-1 protein through a ubiquitination-mediated mechanism. The international journal of biochemistry & cell biology 20060101
PKC and MAPKs pathways mediate EGF-induced stimulation of 2-deoxyglucose uptake in mouse embryonic stem cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20060101
The tramadol metabolite, O-desmethyl tramadol, inhibits 5-hydroxytryptamine type 2C receptors expressed in Xenopus Oocytes. Pharmacology 20060101
Development of autonomic receptors and their function in the chick heart and influence of continuous infusion of carbachol. Prague medical report 20060101
Urokinase induces matrix metalloproteinase-9/gelatinase B expression in THP-1 monocytes via ERK1/2 and cytosolic phospholipase A2 activation and eicosanoid production. Journal of vascular research 20060101
Role of protein kinase C in hydroxyapatite- induced phagocytosis by a murine macrophage cell line (RAW264.7). Immunopharmacology and immunotoxicology 20060101
IGF regulation of neutral amino acid transport in the BeWo choriocarcinoma cell line (b30 clone): evidence for MAP kinase-dependent and MAP kinase-independent mechanisms. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 20060101
Acrylonitrile-induced extracellular signal-regulated kinase (ERK) activation via protein kinase C (PKC) in SK-N-SH neuroblastoma cells. Journal of applied toxicology : JAT 20060101
Protein kinase C isoform specificity of cholinergic potentiation of glucose-induced pulsatile 5-HT/ insulin release from mouse pancreatic islets. Biological research 20060101
Differential actin isoform reorganization in the contracting A7r5 cell. Canadian journal of physiology and pharmacology 20060101
SLC26 transporters and the inhibitory control of pancreatic ductal bicarbonate secretion. Novartis Foundation symposium 20060101
Inhibition of PKC activity blocks the increase of ETB receptor expression in cerebral arteries. BMC pharmacology 20060101
PKC pathway and ERK/MAPK pathway are required for induction of cyclin D1 and p21Waf1 during 12-o-tetradecanoylphorbol 13-acetate-induced differentiation of myeloleukemia cells. The Kobe journal of medical sciences 20060101
A role of opening of mitochondrial ATP-sensitive potassium channels in the infarct size-limiting effect of ischemic preconditioning via activation of protein kinase C in the canine heart. Biochemical and biophysical research communications 20051223
Structure and substrate specificity of the Pim-1 kinase. The Journal of biological chemistry 20051216
Prostaglandin E2 induces cyclooxygenase-2 expression in human non-pigmented ciliary epithelial cells through activation of p38 and p42/44 mitogen-activated protein kinases. Biochemical and biophysical research communications 20051216
Neonatal isolation accelerates the developmental switch in the signalling cascades for long-term potentiation induction. The Journal of physiology 20051215
Psychoactive substrates stimulate dopamine transporter phosphorylation and down-regulation by cocaine-sensitive and protein kinase C-dependent mechanisms. The Journal of biological chemistry 20051209
Pityriarubins, novel highly selective inhibitors of respiratory burst from cultures of the yeast Malassezia furfur: comparison with the bisindolylmaleimide arcyriarubin A. Chembiochem : a European journal of chemical biology 20051201
Intermittent high glucose enhances ICAM-1, VCAM-1 and E-selectin expression in human umbilical vein endothelial cells in culture: the distinct role of protein kinase C and mitochondrial superoxide production. Atherosclerosis 20051201
Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase. Journal of medicinal chemistry 20051201
Opposing effects of phorbol-12-myristate-13-acetate, an activator of protein kinase C, on the signaling of structurally related human dopamine D1 and D5 receptors. Journal of neurochemistry 20051201
Induction of neurite outgrowth by (-)-(7R, 8S)-dihydrodehydrodiconiferyl alcohol from PC12 cells. Archives of pharmacal research 20051201
Morphine activates Arc expression in the mouse striatum and in mouse neuroblastoma Neuro2A MOR1A cells expressing mu-opioid receptors. Journal of neuroscience research 20051115
Atypical PKC-zeta and PKC-iota mediate opposing effects on MCF-7 Na+/K+ATPase activity. Journal of cellular physiology 20051101
Involvement of nuclear factor kappaB in up-regulation of aldose reductase gene expression by 12-O-tetradecanoylphorbol-13-acetate in HeLa cells. The international journal of biochemistry & cell biology 20051101
Regulation of angiotensin-converting enzyme production by nicotine in human endothelial cells. American journal of physiology. Heart and circulatory physiology 20051101
Relative contribution of Rho kinase and protein kinase C to myogenic tone in rat cerebral arteries in hypertension. American journal of physiology. Heart and circulatory physiology 20051101
Subnanomolar concentrations of thrombin enhance the volume-sensitive efflux of taurine from human 1321N1 astrocytoma cells. The Journal of pharmacology and experimental therapeutics 20051101
Adenosine A2A receptor stimulation potentiates nitric oxide release by activated microglia. Journal of neurochemistry 20051101
Signal transduction pathways of group I metabotropic glutamate receptor-induced long-term depression at sensory spinal synapses. Pain 20051101
Role of protein kinase C in expression of granulocyte-colony stimulating factor and granulocyte macrophage-colony stimulating factor in lung cancer cells. International journal of molecular medicine 20051101
8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid stimulates GABA release from interneurons projecting to CA1 pyramidal neurons in the rat hippocampus via pre-synaptic alpha7 acetylcholine receptors. Journal of neurochemistry 20051101
Suppression of protein kinase Cepsilon mediates 17beta-estradiol-induced neuroprotection in an immortalized hippocampal cell line. Journal of neurochemistry 20051101
Effects of dexmedetomidine on hippocampal focal adhesion kinase tyrosine phosphorylation in physiologic and ischemic conditions. Anesthesiology 20051101
Modulation of Na+ transport and epithelial sodium channel expression by protein kinase C in rat alveolar epithelial cells. Canadian journal of physiology and pharmacology 20051101
PKC pathway associated with the expression of an A-type K+ channel induced by TGF-beta1 in rat vascular myofibroblasts. Biochemical and biophysical research communications 20051028
Configurational stability of bisindolylmaleimide cyclophanes: from conformers to the first configurationally stable, atropisomeric bisindolylmaleimides. Chemistry (Weinheim an der Bergstrasse, Germany) 20051021
Enhanced ubiquitylation and accelerated degradation of the dopamine transporter mediated by protein kinase C. The Journal of biological chemistry 20051021
Effect of adenosine triphosphate on phosphate uptake in renal proximal tubule cells: involvement of PKC and p38 MAPK. Journal of cellular physiology 20051001
Diacylglycerol-containing docosahexaenoic acid in acyl chain modulates airway smooth muscle tone. American journal of respiratory cell and molecular biology 20051001
Inhibitory effects of 12-O-tetradecanoylphorbol-13-acetate alone or in combination with all-trans retinoic acid on the growth of cultured human pancreas cancer cells and pancreas tumor xenografts in immunodeficient mice. The Journal of pharmacology and experimental therapeutics 20051001
Acetoacetate induces CYP2E1 protein and suppresses CYP2E1 mRNA in primary cultured rat hepatocytes. The Journal of pharmacology and experimental therapeutics 20051001
EGF rapidly translocates tight junction proteins from the cytoplasm to the cell-cell contact via protein kinase C activation in TMK-1 gastric cancer cells. Experimental cell research 20051001
Chronic nitroglycerine administration reduces endothelial nitric oxide production in rabbit mesenteric resistance artery. British journal of pharmacology 20051001
TGF-beta1 induces cardiac hypertrophic responses via PKC-dependent ATF-2 activation. Journal of molecular and cellular cardiology 20051001
Acoustic environment determines phosphorylation state of the Kv3.1 potassium channel in auditory neurons. Nature neuroscience 20051001
Cooling-induced contraction of the rat gastric fundus: mediation via transient receptor potential (TRP) cation channel TRPM8 receptor and Rho-kinase activation. Clinical and experimental pharmacology & physiology 20051001
G-protein-coupled receptor agonists differentially regulate basal or tumor necrosis factor-alpha-stimulated activation of interleukin-6 and RANTES in human airway smooth muscle cells. Journal of biomedical science 20051001
Nitric oxide induces acrosome reaction in cryopreserved bovine spermatozoa. Andrologia 20051001
Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif. Journal of molecular biology 20050930
Activation of ERK during DNA damage-induced apoptosis involves protein kinase Cdelta. Biochemical and biophysical research communications 20050909
Signaling pathways of hypocretin-1 actions on pyramidal neurons in the rat prefrontal cortex. Neuroreport 20050908
Contributions of the mitogen-activated protein kinase and protein kinase C cascades in spatial learning and memory mediated by the nucleus accumbens. The Journal of pharmacology and experimental therapeutics 20050901
The hypoglycaemic activity of fenugreek seed extract is mediated through the stimulation of an insulin signalling pathway. British journal of pharmacology 20050901
Mechanisms involved in the nociception produced by peripheral protein kinase c activation in mice. Pain 20050901
Involvement of Ca2+ sensitization in ropivacaine-induced contraction of rat aortic smooth muscle. Anesthesiology 20050901
Protein kinase C inhibition and x-linked inhibitor of apoptosis protein degradation contribute to the sensitization effect of luteolin on tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cancer cells. Cancer research 20050901
Poly(ADP-ribose) polymerase-1 is a novel nuclear target for cholinergic receptor signaling in the hippocampus. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20050901
ANG II increases 2-deoxyglucose uptake in mouse embryonic stem cells. Life sciences 20050826
Keratin 8 phosphorylation by protein kinase C delta regulates shear stress-mediated disassembly of keratin intermediate filaments in alveolar epithelial cells. The Journal of biological chemistry 20050826
Sequential phosphorylation mediates receptor- and kinase-induced inhibition of TREK-1 background potassium channels. The Journal of biological chemistry 20050826
Comparison of the ATP binding sites of protein kinases using conformationally diverse bisindolylmaleimides. Journal of the American Chemical Society 20050824
PHI-1 induced enhancement of myosin phosphorylation in chicken smooth muscle. FEBS letters 20050815
Anti-adipogenic effect of PDGF is reversed by PKC inhibition. Journal of cellular physiology 20050801
RhoA-Rho kinase pathway mediates thrombin- and U-46619-induced phosphorylation of a myosin phosphatase inhibitor, CPI-17, in vascular smooth muscle cells. American journal of physiology. Cell physiology 20050801
PKC-dependent, burn-induced adherens junction reorganization and barrier dysfunction in pulmonary microvascular endothelial cells. American journal of physiology. Lung cellular and molecular physiology 20050801
Angiotensin II induced increase in frequency of cytosolic and nuclear calcium waves of heart cells via activation of AT1 and AT2 receptors. Peptides 20050801
Role of mitogen activated protein kinases and protein kinase C in cadmium-induced apoptosis of primary epithelial lung cells. Toxicology 20050801
Lipopolysaccharide stimulates the secretion of the amyloid precursor protein via a protein kinase C-mediated pathway. Neurobiology of disease 20050801
Inhibition of protein kinases C prevents murine cytomegalovirus replication. The Journal of general virology 20050801
Angiotensin II-induced increase of T-type Ca2+ current and decrease of L-type Ca2+ current in heart cells. Peptides 20050801
Glycogen synthase kinase 3-dependent phosphorylation of Mdm2 regulates p53 abundance. Molecular and cellular biology 20050801
Role of protein kinase C on the alteration of retinal endothelin-1 in streptozotocin-induced diabetic rats. Experimental eye research 20050801
Chlamydia pneumoniae induces nitric oxide synthase and lipoxygenase-dependent production of reactive oxygen species in platelets. Effects on oxidation of low density lipoproteins. Thrombosis and haemostasis 20050801
Signaling pathway in nerve growth factor induced histamine release from rat mast cells. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20050801
Effect of protein kinase C activation on intracellular Ca2+ signaling and integrity of intestinal epithelial cells. European journal of pharmacology 20050725
Increased expression of G11alpha in osteoblastic cells enhances parathyroid hormone activation of phospholipase C and AP-1 regulation of matrix metalloproteinase-13 mRNA. Journal of cellular physiology 20050701
Protein kinase C epsilon regulates tumor necrosis factor-alpha-induced stannin gene expression. The Journal of pharmacology and experimental therapeutics 20050701
Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons. Brain : a journal of neurology 20050701
Activity-dependent subcellular localization of NAC1. The European journal of neuroscience 20050701
PKC alpha-dependent regulation of the IGF1 receptor in adult and embryonic rat cardiomyocytes. Molecular and cellular biochemistry 20050701
Prostaglandin E2 stimulates fibronectin expression through EP1 receptor, phospholipase C, protein kinase Calpha, and c-Src pathway in primary cultured rat osteoblasts. The Journal of biological chemistry 20050617
The protein kinase C inhibitor, bisindolylmaleimide (I), inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells. Life sciences 20050617
Protein kinase C-independent pathway for NADPH oxidase activation in guinea pig peritoneal polymorphonuclear leukocytes by cytochalasin D. Archives of biochemistry and biophysics 20050615
Structure-activity relationship of N-methyl-bisindolylmaleimide derivatives as cell death inhibitors. Bioorganic & medicinal chemistry letters 20050615
Thrombin modulates the expression of a set of genes including thrombospondin-1 in human microvascular endothelial cells. The Journal of biological chemistry 20050610
Protein kinase C contributes to abnormal capsaicin responses in DRG neurons from cats with feline interstitial cystitis. Neuroscience letters 20050610
PKC-alpha-mediated remodeling of the actin cytoskeleton is involved in constitutive albumin uptake by proximal tubule cells. American journal of physiology. Renal physiology 20050601
Sphingosine 1-phosphate protects mouse extensor digitorum longus skeletal muscle during fatigue. American journal of physiology. Cell physiology 20050601
Metabolites of benzene are potent inhibitors of gap-junction intercellular communication. Archives of toxicology 20050601
Cell cycle signaling by endothelin-1 requires Src nonreceptor protein tyrosine kinase. Molecular pharmacology 20050601
Artocarpol A stimulation of superoxide anion generation in neutrophils involved the activation of PLC, PKC and p38 mitogen-activated PK signaling pathways. British journal of pharmacology 20050601
Effects of bisindolylmaleimide PKC inhibitors on p90RSK activity in vitro and in adult ventricular myocytes. British journal of pharmacology 20050601
The role of intracellular Ca2+ in the regulation of proteinase-activated receptor-2 mediated nuclear factor kappa B signalling in keratinocytes. British journal of pharmacology 20050601
The interaction of isoflurane and protein kinase C-activators on sarcolemmal KATP channels. Anesthesia and analgesia 20050601
Potentiation of beta-adrenoceptor function in bovine tracheal smooth muscle by inhibition of protein kinase C. European journal of pharmacology 20050523
P2Y2 nucleotide receptors enhance alpha-secretase-dependent amyloid precursor protein processing. The Journal of biological chemistry 20050513
Production of NGF, BDNF and GDNF in mouse astrocyte cultures is strongly enhanced by a cerebral vasodilator, ifenprodil. Neuroscience letters 20050513
Mitogen-activated protein kinase contributes to elevated basal tone in aortic smooth muscle from hypertensive rats. European journal of pharmacology 20050509
Insulin stimulates Ca2+ uptake via PKC, cAMP, and p38 MAPK in mouse embryonic stem cells. Life sciences 20050506
Protein kinase C mediates the inhibitory effect of substance P on HCO3- secretion from guinea pig pancreatic ducts. American journal of physiology. Cell physiology 20050501
A role for ERK1/2 in EGF- and ATP-dependent regulation of amiloride-sensitive sodium absorption. American journal of physiology. Cell physiology 20050501
Clozapine potentiation of N-methyl-D-aspartate receptor currents in the nucleus accumbens: role of NR2B and protein kinase A/Src kinases. The Journal of pharmacology and experimental therapeutics 20050501
Exaggerated coronary vasoreactivity to endothelin-1 in aged rats: role of protein kinase C. Cardiovascular research 20050501
Remifentanil mimics cardioprotective effect of ischemic preconditioning via protein kinase C activation in open chest of rats. Acta pharmacologica Sinica 20050501
Effects of AMP579 and adenosine on L-type Ca2+ current in isolated rat ventricular myocytes. Acta pharmacologica Sinica 20050501
Prolonged Alzheimer-like tau hyperphosphorylation induced by simultaneous inhibition of phosphoinositol-3 kinase and protein kinase C in N2a cells. Acta biochimica et biophysica Sinica 20050501
Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells. The Journal of biological chemistry 20050429
Adenosine-dependent induction of glutathione peroxidase 1 in human primary endothelial cells and protection against oxidative stress. Circulation research 20050429
Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members. Blood 20050415
Dopamine and norepinephrine transporter-dependent c-Fos production in vitro: relevance to neuroadaptation. Journal of neuroscience methods 20050415
Galphaq potentiation of adenylate cyclase type 9 activity through a Ca2+/calmodulin-dependent pathway. Biochemical pharmacology 20050415
Metabotropic glutamate receptors and dopamine receptors cooperate to enhance extracellular signal-regulated kinase phosphorylation in striatal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 20050413
IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner. The Journal of biological chemistry 20050408
Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells. American journal of physiology. Cell physiology 20050401
Thromboxane prostanoid receptor signals through Gi protein to rapidly activate extracellular signal-regulated kinase in human airways. American journal of respiratory cell and molecular biology 20050401
Gefitinib ('Iressa', ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells. Cancer chemotherapy and pharmacology 20050401
Bradykinin potentiates 5-HT3 receptor-mediated current in rat trigeminal ganglion neurons. Acta pharmacologica Sinica 20050401
Regulation of the human atrial myosin light chain 1 promoter by Ca2+-calmodulin-dependent signaling pathways. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050401
Role of vascular endothelial growth factor receptor 1 and vascular endothelial growth factor receptor 2 in the vasodilator response to vascular endothelial growth factor in the neonatal piglet lung. Critical care medicine 20050401
Antecedent ethanol ingestion prevents postischemic leukocyte adhesion and P-selectin expression by a protein kinase C-dependent mechanism. Digestive diseases and sciences 20050401
Bradykinin upregulates IL-8 production in human gingival fibroblasts stimulated by interleukin-1beta and tumor necrosis factor alpha. Regulatory peptides 20050330
Blockade of chloride conductance antagonizes PMA-induced ramification in the murine microglial cell line, BV-2. Brain research 20050328
Induction of human leukemia HL-60 cell differentiation via a PKC/ERK pathway by helenalin, a pseudoguainolide sesquiterpene lactone. European journal of pharmacology 20050328
Casein kinase II (CK2) enhances death-inducing signaling complex (DISC) activity in TRAIL-induced apoptosis in human colon carcinoma cell lines. Oncogene 20050317
Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells. The Journal of biological chemistry 20050304
Eplerenone blocks nongenomic effects of aldosterone on the Na+/H+ exchanger, intracellular Ca2+ levels, and vasoconstriction in mesenteric resistance vessels. Endocrinology 20050301
Treatment with AT(1) receptor blocker restores diabetes-induced alterations in intracellular Ca(2+) transients and contractile function of rat myocardium. Archives of biochemistry and biophysics 20050301
Translation modulation of acid beta-glucosidase in HepG2 cells: participation of the PKC pathway. Molecular genetics and metabolism 20050301
Activation of protein kinase C reduces benzodiazepine potency at GABAA receptors in NT2-N neurons. Neuropharmacology 20050301
mGluRs induce a long-term depression in the ventral tegmental area that involves a switch of the subunit composition of AMPA receptors. The European journal of neuroscience 20050301
The effects of the neurosteroids: pregnenolone, progesterone and dehydroepiandrosterone on muscarinic receptor-induced responses in Xenopus oocytes expressing M1 and M3 receptors. Naunyn-Schmiedeberg's archives of pharmacology 20050301
In vivo effects of protein kinase and phosphatase inhibitors on CYP2B induction in rat liver. Toxicology 20050214
Protein kinase C modulates agonist-sensitive release of Ca2+ from internal stores in HEK293 cells overexpressing the calcium sensing receptor. The Journal of biological chemistry 20050211
Platelet-derived growth factor-BB-induced human smooth muscle cell proliferation depends on basic FGF release and FGFR-1 activation. Circulation research 20050204
RANTES (CCL5) induces a CCR5-dependent accelerated shedding of syndecan-1 (CD138) and syndecan-4 from HeLa cells and forms complexes with the shed ectodomains of these proteoglycans as well as with those of CD44. Glycobiology 20050201
The tamoxifen-induced suppression of telomerase activity in the human hepatoblastoma cell line HepG2: a result of post-translational regulation. Journal of cancer research and clinical oncology 20050201
Multiphoton-FLIM quantification of the EGFP-mRFP1 FRET pair for localization of membrane receptor-kinase interactions. Biophysical journal 20050201
Moraxella catarrhalis--infected alveolar epithelium induced monocyte recruitment and oxidative burst. American journal of respiratory cell and molecular biology 20050201
Nitric oxide-induced capacitation of cryopreserved bull spermatozoa and assessment of participating regulatory pathways. Animal reproduction science 20050201
Mechanisms of angiotensin II-mediated decreases in intraneuronal Ca2+ in calcium-loaded stellate ganglion neurons. Hypertension (Dallas, Tex. : 1979) 20050201
Hyperresponsiveness on washout of volatile anesthetics from isolated spinal cord compared to withdrawal from ethanol. Anesthesia and analgesia 20050201
Intercellular communication via gap junctions in activated rat hepatic stellate cells. Gastroenterology 20050201
Protein kinase C blockade inhibits differentiation of myeloid blasts into dendritic cells by calcium ionophore A23187. International journal of hematology 20050201
Pro- and anti-apoptotic roles of c-Jun N-terminal kinase (JNK) in ethanol and acetaldehyde exposed rat hepatocytes. European journal of pharmacology 20050131
Atypical protein kinase C is a novel mediator of dopamine-enhanced firing in nucleus accumbens neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 20050126
Connexin43 synthesis, phosphorylation, and degradation in regulation of transient inhibition of gap junction intercellular communication by the phorbol ester TPA in rat liver epithelial cells. Experimental cell research 20050115
Early painful diabetic neuropathy is associated with differential changes in the expression and function of vanilloid receptor 1. The Journal of biological chemistry 20050107
Intracellular signaling specificity in response to uniaxial vs. multiaxial stretch: implications for mechanotransduction. American journal of physiology. Cell physiology 20050101
Protein kinase C pathway is involved in transcriptional regulation of C-reactive protein synthesis in human hepatocytes. Arteriosclerosis, thrombosis, and vascular biology 20050101
The linoleic acid derivative FR236924 facilitates hippocampal synaptic transmission by enhancing activity of presynaptic alpha7 acetylcholine receptors on the glutamatergic terminals. Neuroscience 20050101
Signaling pathways mediating gastrointestinal smooth muscle contraction and MLC20 phosphorylation by motilin receptors. American journal of physiology. Gastrointestinal and liver physiology 20050101
A study of signal transduction for the two diuretic peptides of Diploptera punctata. Peptides 20050101
Tumor necrosis factor alpha and epidermal growth factor act additively to inhibit matrix gene expression by chondrocyte. Arthritis research & therapy 20050101
Different pathways leading to activation of extracellular signal-regulated kinase and p38 MAP kinase by formyl-methionyl-leucyl-phenylalanine or platelet activating factor in human neutrophils. Journal of biomedical science 20050101
Activation of protein kinase C alpha is required for TPA-triggered ERK (MAPK) signaling and growth inhibition of human hepatoma cell HepG2. Journal of biomedical science 20050101
[FLIP--an enemy which might lose the battle against the specific inhibitors of translation]. Postepy higieny i medycyny doswiadczalnej (Online) 20050101
Differential role of an atypical protein kinase C, PKC zeta, in regulation of human eosinophil and neutrophil functions. International archives of allergy and immunology 20050101
Ischemic preconditioning: a potential role for protein S-thiolation? Antioxidants & redox signaling 20050101
Multiple phosphorylation events control mitotic degradation of the muscle transcription factor Myf5. BMC biochemistry 20050101
Protein kinase C activation promotes the internalization of the human cationic amino acid transporter hCAT-1. A new regulatory mechanism for hCAT-1 activity. The Journal of biological chemistry 20041224
IkappaBalpha (inhibitory kappaBalpha) identified as labile repressor of MnSOD (manganese superoxide dismutase) expression. The Biochemical journal 20041215
Alterations in receptor expression or agonist concentration change the pathways gastrin-releasing peptide receptor uses to regulate extracellular signal-regulated kinase. Molecular pharmacology 20041201
Protein kinase C activation enhances morphine-induced rapid desensitization of mu-opioid receptors in mature rat locus ceruleus neurons. Molecular pharmacology 20041201
Protein kinase C mediates cisplatin-induced loss of adherens junctions followed by apoptosis of renal proximal tubular epithelial cells. The Journal of pharmacology and experimental therapeutics 20041201
Differential in vitro neurotoxicity of the flame retardant PBDE-99 and of the PCB Aroclor 1254 in human astrocytoma cells. Toxicology letters 20041201
Prevotella intermedia lipopolysaccharide stimulates release of nitric oxide by inducing expression of inducible nitric oxide synthase. Journal of periodontal research 20041201
Inhibition of calcium-calmodulin kinase restores nitric oxide production and signaling in submandibular glands of a mouse model of salivary dysfunction. British journal of pharmacology 20041201
Direct block of hERG potassium channels by the protein kinase C inhibitor bisindolylmaleimide I (GF109203X). Cardiovascular research 20041201
Differential regulation of GLAST immunoreactivity and activity by protein kinase C: evidence for modification of amino and carboxyl termini. Journal of neurochemistry 20041201
Reactive oxygen species blockade and action of insulin on expression of angiotensinogen gene in proximal tubular cells. The Journal of endocrinology 20041201
Aldosterone directly stimulates cardiac myocyte hypertrophy. Journal of cardiac failure 20041201
P2Y receptors and pain transmission. Purinergic signalling 20041201
Protein kinase C mediates phosphorylation, desensitization, and trafficking of the D2 dopamine receptor. The Journal of biological chemistry 20041119
Specificity of action of bisindolylmaleimide protein kinase C inhibitors: do they inhibit the 70kDa ribosomal S6 kinase in cardiac myocytes? Biochemical pharmacology 20041115
Autocrine transforming growth factor alpha regulates cell adhesion by multiple signaling via specific phosphorylation sites of p70S6 kinase in colon cancer cells. The Journal of biological chemistry 20041105
Protein kinase C activity regulates the onset of anaphase I in mouse oocytes. Biology of reproduction 20041101
Acute regulation of OAT3-mediated estrone sulfate transport in isolated rabbit renal proximal tubules. American journal of physiology. Renal physiology 20041101
Regulation of cleavage by protein kinase C in Chaetopterus. Molecular reproduction and development 20041101
Gq/G13 signaling by ET-1 in smooth muscle: MYPT1 phosphorylation via ETA and CPI-17 dephosphorylation via ETB. American journal of physiology. Cell physiology 20041101
Protein kinase C delta is required for p47phox phosphorylation and translocation in activated human monocytes. Journal of immunology (Baltimore, Md. : 1950) 20041101
Expression of placenta growth factor is regulated by both VEGF and hyperglycaemia via VEGFR-2. Microvascular research 20041101
Histamine reduces gap junctional communication of human tonsil high endothelial cells in culture. Microvascular research 20041101
Protein kinase C inhibitors produce mitochondrial flavoprotein oxidation in cardiac myocytes. Anesthesia and analgesia 20041101
Mechanisms of mitogen-activated protein kinase inhibition by parathyroid hormone in osteoblast-like cells. Journal of the American Society of Nephrology : JASN 20041101
Potentiation of 5-HT3 receptor function by the activation of coexistent 5-HT2 receptors in trigeminal ganglion neurons of rats. Neuropharmacology 20041101
Endothelin-1 induces cyclooxygenase-2 expression and generation of reactive oxygen species in endothelial cells. Journal of cardiovascular pharmacology 20041101
A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different classes of novel Pfmrk specific inhibitors. Journal of medicinal chemistry 20041021
Vascular endothelial growth factor-mediated induction of manganese superoxide dismutase occurs through redox-dependent regulation of forkhead and IkappaB/NF-kappaB. The Journal of biological chemistry 20041015
Intracellular mechanisms mediating the anti-apoptotic action of gastrin. Biochemical and biophysical research communications 20041008
Evaluation of alternative approaches for the synthesis of macrocyclic bisindolylmaleimides. Organic & biomolecular chemistry 20041007
Rho/Rho kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats. American journal of physiology. Lung cellular and molecular physiology 20041001
Ghrelin induces vasoconstriction in the rat coronary vasculature without altering cardiac peptide secretion. American journal of physiology. Heart and circulatory physiology 20041001
Vascular endothelial growth factor stimulates differential signaling pathways in in vivo microcirculation. American journal of physiology. Heart and circulatory physiology 20041001
Regulation of CCK-induced amylase release by PKC-delta in rat pancreatic acinar cells. American journal of physiology. Gastrointestinal and liver physiology 20041001
Matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 production in human gingival fibroblasts: the role of protein kinase C. Journal of periodontal research 20041001
Reversible connexin 43 dephosphorylation during hypoxia and reoxygenation is linked to cellular ATP levels. Circulation research 20041001
Glutamate-dependent transcriptional regulation of GLAST: role of PKC. Journal of neurochemistry 20041001
A brief regional ischemic-reperfusion enhances propofol-induced depression in left ventricular function of in situ rat hearts. Anesthesiology 20041001
Inhibition of Chk1 by the G2 DNA damage checkpoint inhibitor isogranulatimide. Molecular cancer therapeutics 20041001
Autophosphorylation suppresses whereas kinase inhibition augments the translocation of protein kinase Calpha in response to diacylglycerol. The Journal of biological chemistry 20040924
Exploring the pharmacology of the leukotriene B4 receptor BLT1, without the confounding effects of BLT2. European journal of pharmacology 20040919
Mechanisms of hydroxyl radical-induced contraction of rat aorta. European journal of pharmacology 20040919
Enhanced retinoid-induced apoptosis of MDA-MB-231 breast cancer cells by PKC inhibitors involves activation of ERK. Oncogene 20040916
Ca2+-mediated potentiation of the swelling-induced taurine efflux from HeLa cells: on the role of calmodulin and novel protein kinase C isoforms. The Journal of membrane biology 20040915
TIS21/BTG2/PC3 is expressed through PKC-delta pathway and inhibits binding of cyclin B1-Cdc2 and its activity, independent of p53 expression. Experimental cell research 20040910
Insulin induces alpha1B-adrenergic receptor phosphorylation and desensitization. Life sciences 20040903
High glucose inhibits fructose uptake in renal proximal tubule cells: involvement of cAMP, PLC/PKC, p44/42 MAPK, and cPLA2. Journal of cellular physiology 20040901
Deregulation of PKB influences antiapoptotic signaling by PKC in breast cancer cells. International journal of oncology 20040901
Development of a respiratory burst assay using zebrafish kidneys and embryos. Journal of immunological methods 20040901
Src family tyrosine kinases inhibit single L-type: Ca2+ channel activity in human atrial myocytes. Journal of molecular and cellular cardiology 20040901
Differing roles of protein kinase C-zeta in disruption of tight junction barrier by enteropathogenic and enterohemorrhagic Escherichia coli. Gastroenterology 20040901
Possible involvement of protein kinase C activation in differentiation of human umbilical vein endothelium-derived cell into smooth muscle-like cell. Biology of the cell 20040901
Activation of second messenger-dependent protein kinases induces muscarinic acetylcholine receptor desensitization in rat thyroid epithelial cells. Molecular and cellular endocrinology 20040831
Protein kinase Calpha translocates to the perinuclear region to activate phospholipase D1. The Journal of biological chemistry 20040820
Gene- and cell-type-specific effects of signal transduction cascades on metal-regulated gene transcription appear to be independent of changes in the phosphorylation of metal-response-element-binding transcription factor-1. The Biochemical journal 20040815
G-protein-coupled receptor regulation of P2X1 receptors does not involve direct channel phosphorylation. The Biochemical journal 20040815
Muscarinic modulation of erg potassium current. The Journal of physiology 20040815
Inhibition of Ca2+-dependent PKC isoforms unmasks ERK-dependent hypertrophic growth evoked by phenylephrine in adult ventricular cardiomyocytes. Cardiovascular research 20040815
Protein kinase C alpha/beta inhibitor Go6976 promotes formation of cell junctions and inhibits invasion of urinary bladder carcinoma cells. Cancer research 20040815
Activation of protein kinase C antagonizes the opioid inhibition of calcium current in rat spinal dorsal horn neurons. Brain research 20040813
Acetoacetate activation of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in primary cultured rat hepatocytes: role of oxidative stress. The Journal of pharmacology and experimental therapeutics 20040801
Atypical protein-kinase Czeta, but neither conventional Ca2+ -dependent protein-kinase C isoenzymes nor Ca2+ -calmodulin, participates in regulation of telomerase activity in Burkitt's lymphoma cells. Cancer chemotherapy and pharmacology 20040801
Mechanism of cicaprost-induced desensitization in rat pulmonary artery smooth muscle cells involves a PKA-mediated inhibition of adenylyl cyclase. American journal of physiology. Lung cellular and molecular physiology 20040801
Stimulation of intracellular Ca2+ oscillations by diacylglycerol in human myometrial cells. Cell calcium 20040801
Thiopental and isoflurane attenuate the decrease in hippocampal phosphorylated Focal Adhesion Kinase (pp125FAK) content induced by oxygen-glucose deprivation. British journal of anaesthesia 20040801
The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040801
Curcumin inhibits cell motility and alters microfilament organization and function in prostate cancer cells. Cell motility and the cytoskeleton 20040801
Ca2+ sensitization in contraction of human bladder smooth muscle. The Journal of urology 20040801
Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogen-activated protein kinase pathway. European journal of endocrinology 20040801
Induction of nerve growth factor by butanol fraction of Liriope platyphylla in C6 and primary astrocyte cells. Biological & pharmaceutical bulletin 20040801
Modulation of presynaptic activity by phosphorylation in cultured rat spinal dorsal horn neurons. The journal of pain : official journal of the American Pain Society 20040801
Inverted signaling hierarchy between RAS and RAC in T-lymphocytes. Oncogene 20040729
Hepatocyte resistance to oxidative stress is dependent on protein kinase C-mediated down-regulation of c-Jun/AP-1. The Journal of biological chemistry 20040723
Histological protection against ischemia-reperfusion injury by early ischemic preconditioning in rat retina. Brain research 20040723
LDL oxidized by hypochlorous acid causes irreversible platelet aggregation when combined with low levels of ADP, thrombin, epinephrine, or macrophage-derived chemokine (CCL22). Blood 20040715
Bcl-x(S) induces an NGF-inhibitable cytochrome c release. Experimental cell research 20040715
Glutamate transporter cluster formation in astrocytic processes regulates glutamate uptake activity. The Journal of neuroscience : the official journal of the Society for Neuroscience 20040714
Protein kinase C inhibition differentially affects 3,4-methylenedioxymethamphetamine-induced dopamine release in the striatum and prefrontal cortex of the rat. Brain research 20040709
Modulation of beta2- and beta3-adrenoceptor-mediated relaxation of rat oesophagus smooth muscle by protein kinase C. European journal of pharmacology 20040708
Lysophosphatidic acid induces exocytic trafficking of Na(+)/H(+) exchanger 3 by E3KARP-dependent activation of phospholipase C. Biochimica et biophysica acta 20040705
PKC-independent inhibition of neuronal nicotinic acetylcholine receptors by diacylglycerol. Brain research 20040702
Vitamin E activates CRABP-II gene expression in cultured human fibroblasts, role of protein kinase C. FEBS letters 20040702
Novel regulatory properties of human type 9 adenylate cyclase. The Journal of pharmacology and experimental therapeutics 20040701
Prolonged extracellular signal-regulated kinase 1/2 activation during fibroblast growth factor 1- or heregulin beta1-induced antiestrogen-resistant growth of breast cancer cells is resistant to mitogen-activated protein/extracellular regulated kinase kinase inhibitors. Cancer research 20040701
Endothelin 1 and 3 enhance neuronal nitric oxide synthase activity through ETB receptors involving multiple signaling pathways in the rat anterior hypothalamus. Peptides 20040701
Exaggerated nociceptive responses on morphine withdrawal: roles of protein kinase C epsilon and gamma. Pain 20040701
Signal transduction underlying carbachol-induced contraction of human urinary bladder. The Journal of pharmacology and experimental therapeutics 20040601
Induction of manganese-superoxide dismutase by YS 51, a synthetic 1-(beta-naphtylmethyl)6,7-dihydroxy- 1,2,3,4-tetrahydroisoquinoline alkaloid: implication for anti-inflammatory actions. Pharmacology 20040601
Activation of histamine H1-receptor enhances neurotrophic factor secretion from cultured astrocytes. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20040601
Injured brain endothelial cells release neurotoxic thrombin. Journal of Alzheimer's disease : JAD 20040601
The protein kinase C inhibitor bisindolyl maleimide 2 binds with reversed orientations to different conformations of protein kinase A. The Journal of biological chemistry 20040528
PKC and PKA inhibitors reverse tolerance to morphine-induced hypothermia and supraspinal analgesia in mice. European journal of pharmacology 20040525
Regulation of phospholipase D2 activity by protein kinase C alpha. The Journal of biological chemistry 20040521
Cross-talk between protein kinases Czeta and B in cyclic AMP-mediated sodium taurocholate co-transporting polypeptide translocation in hepatocytes. The Journal of biological chemistry 20040514
Engagement of beta2 integrins recruits 14-3-3 proteins to c-Cbl in human neutrophils. Biochemical and biophysical research communications 20040514
Prostaglandin F2alpha amplifies tumor necrosis factor-alpha promoter activity by the FPB prostanoid receptor. Biochemical and biophysical research communications 20040514
Towards configurationally stable bisindolylmaleimide cyclophanes: potential tools for investigating protein kinase function. Chemical communications (Cambridge, England) 20040507
Active involvement of PKC for insulin-mediated rates of muscle protein synthesis in Zucker rats. American journal of physiology. Endocrinology and metabolism 20040501
Localization of VEGFR-2 and PLD2 in endothelial caveolae is involved in VEGF-induced phosphorylation of MEK and ERK. American journal of physiology. Heart and circulatory physiology 20040501
Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors. Molecular & cellular proteomics : MCP 20040501
Sphingosine-1-phosphate inhibits C-type natriuretic peptide activation of guanylyl cyclase B (GC-B/NPR-B). Hypertension (Dallas, Tex. : 1979) 20040501
Epidermal growth factor inhibits 14C-alpha-methyl-D-glucopyranoside uptake in renal proximal tubule cells: involvement of PLC/PKC, p44/42 MAPK, and cPLA2. Journal of cellular physiology 20040501
Evidence for the involvement of protein kinase C in acidic pH-induced contraction in spontaneously hypertensive rat aorta. Pharmacology 20040501
Distinctive G protein-dependent signaling in smooth muscle by sphingosine 1-phosphate receptors S1P1 and S1P2. American journal of physiology. Cell physiology 20040501
Actin microdomains on endothelial cells: association with CD44, ERM proteins, and signaling molecules during quiescence and wound healing. Histochemistry and cell biology 20040501
The inhibitory effects of tramadol on 5-hydroxytryptamine type 2C receptors expressed in Xenopus oocytes. Anesthesia and analgesia 20040501
Transcription factor Ets-1 mediates ischemia- and vascular endothelial growth factor-dependent retinal neovascularization. The American journal of pathology 20040501
Endogenous adenosine modulates epileptiform activity in rat hippocampus in a receptor subtype-dependent manner. The European journal of neuroscience 20040501
Basic calcium phosphate crystal-induced prostaglandin E2 production in human fibroblasts: role of cyclooxygenase 1, cyclooxygenase 2, and interleukin-1beta. Arthritis and rheumatism 20040501
The cytosolic II-III loop of Cav2.3 provides an essential determinant for the phorbol ester-mediated stimulation of E-type Ca2+ channel activity. The European journal of neuroscience 20040501
Glucose-induced binding of the polypyrimidine tract-binding protein (PTB) to the 3'-untranslated region of the insulin mRNA (ins-PRS) is inhibited by rapamycin. Molecular and cellular biochemistry 20040501
Effect of raloxifene and its interaction with human PTH on bone formation. Journal of endocrinological investigation 20040501
Adenosine suppresses GABAA receptor-mediated responses in rat sacral dorsal commissural neurons. Autonomic neuroscience : basic & clinical 20040430
Endothelial dysfunction and altered bradykinin response due to oxidative stress induced by serum deprivation in the bovine cerebral artery. European journal of pharmacology 20040426
Modulatory effect of endothelin-1 and -3 on neuronal norepinephrine release in the rat posterior hypothalamus. Regulatory peptides 20040415
Substance P can stimulate prostaglandin D2 and leukotriene C4 generation without granule exocytosis in murine mast cells. European journal of pharmacology 20040405
Lidocaine increases phosphorylation of focal adhesion kinase in rat hippocampal slices. European journal of pharmacology 20040405
Signaling cascade of ANG II-induced inhibition of alpha-MG uptake in renal proximal tubule cells. American journal of physiology. Renal physiology 20040401
Alterations in PKC signaling underlie enhanced myogenic tone in exercise-trained porcine coronary resistance arteries. Journal of applied physiology (Bethesda, Md. : 1985) 20040401
Prostaglandin F2alpha increases glucose transport in 3T3-L1 adipocytes through enhanced GLUT1 expression by a protein kinase C-dependent pathway. Cellular signalling 20040401
Cooperation between PKC-alpha and PKC-epsilon in the regulation of JNK activation in human lung cancer cells. Cellular signalling 20040401
A critical 'threshold' of beta 2-integrin engagement regulates augmentation of cytokine-mediated superoxide anion release. British journal of pharmacology 20040401
Deletion mutant of FGFR4 induces onion-like membrane structures in the nucleus. Journal of cell science 20040401
Signaling pathways for arsenic-stimulated vascular endothelial growth factor-a expression in primary vascular smooth muscle cells. Chemical research in toxicology 20040401
Blood-retinal barrier breakdown induced by activation of protein kinase C via vascular endothelial growth factor in streptozotocin-induced diabetic rats. Current eye research 20040401
Induction of hyaluronic acid synthase 2 (HAS2) in human vascular smooth muscle cells by vasodilatory prostaglandins. Circulation research 20040319
Ca2+-dependent protein kinase C isoforms induce cholestasis in rat liver. The Journal of biological chemistry 20040312
Evidence of a role for TRPC channels in VEGF-mediated increased vascular permeability in vivo. American journal of physiology. Heart and circulatory physiology 20040301
Pyrimidine nucleotides suppress KDR currents and depolarize rat cerebral arteries by activating Rho kinase. American journal of physiology. Heart and circulatory physiology 20040301
Protein kinase C alpha requirement in the activation of p38 mitogen-activated protein kinase, which is linked to the induction of tumor necrosis factor alpha in lipopolysaccharide-stimulated microglia. Neurochemistry international 20040301
Enhancement of potency and efficacy of NADA by PKC-mediated phosphorylation of vanilloid receptor. Journal of neurophysiology 20040301
Pharmacological profile of nociceptin/orphanin FQ receptors regulating 5-hydroxytryptamine release in the mouse neocortex. The European journal of neuroscience 20040301
Protein kinase C activation by Helicobacter pylori in human gastric epithelial cells limits interleukin-8 production through suppression of extracellular signal-regulated kinase. Journal of pharmacological sciences 20040301
Mechanisms of the influence of magnolol on eicosanoid metabolism in neutrophils. Biochemical pharmacology 20040301
Presynaptic protein kinase C controls maturation and branch dynamics of developing retinotectal arbors: possible role in activity-driven sharpening. Journal of neurobiology 20040215
High glucose-induced upregulation of osteopontin is mediated via Rho/Rho kinase pathway in cultured rat aortic smooth muscle cells. Arteriosclerosis, thrombosis, and vascular biology 20040201
Protein kinase C regulates functional coupling of beta1-adrenergic receptors to Gi/o-mediated responses in cardiac myocytes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040201
Protein kinase C masks nitric oxide synthase activity in vascular smooth muscle under basal conditions. Journal of cardiovascular pharmacology 20040201
Differential modulation of CaV2.3 Ca2+ channels by Galphaq/11-coupled muscarinic receptors. Molecular pharmacology 20040201
Interactions of LY333531 and other bisindolyl maleimide inhibitors with PDK1. Structure (London, England : 1993) 20040201
Angiotensin II potentiates vascular endothelial growth factor-induced proliferation and network formation of endothelial progenitor cells. Hypertension research : official journal of the Japanese Society of Hypertension 20040201
Thyrotropin-releasing hormone increases phospholipase D activity through stimulation of protein kinase C in GH3 cells. Endocrine 20040201
12-O-tetradecanoylphorbol-13-acetate may both potentiate and decrease the generation of apoptosis by the antileukemic agent arsenic trioxide in human promonocytic cells. Regulation by extracellular signal-regulated protein kinases and glutathione. The Journal of biological chemistry 20040130
Direct block by bisindolylmaleimide of the voltage-dependent K+ currents of rat mesenteric arterial smooth muscle. European journal of pharmacology 20040112
Diacylglycerols containing Omega 3 and Omega 6 fatty acids bind to RasGRP and modulate MAP kinase activation. The Journal of biological chemistry 20040109
Involvement of p38 and p42/44 MAP kinases and protein kinase C in the interferon-gamma and interleukin-1alpha-induced phosphorylation of 85-kDa cytosolic phospholipase A(2) in primary human bronchial epithelial cells. Cytokine 20040107
Signal transduction underlying carbachol-induced contraction of rat urinary bladder. II. Protein kinases. The Journal of pharmacology and experimental therapeutics 20040101
Synaptically stimulated induction of group I metabotropic glutamate receptor-dependent long-term depression and depotentiation is inhibited by prior activation of metabotropic glutamate receptors and protein kinase C. Neuroscience 20040101
Novel form of LTD induced by transient, partial inhibition of the Na,K-pump in rat hippocampal CA1 cells. Journal of neurophysiology 20040101
Induction of neurites by the regulatory domains of PKCdelta and epsilon is counteracted by PKC catalytic activity and by the RhoA pathway. Experimental cell research 20040101
Topical application of a protein kinase C inhibitor reduces skin and hair pigmentation. The Journal of investigative dermatology 20040101
Extracellular calcium increases free cytoplasmic calcium and DNA synthesis in human osteoblasts. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20040101
Ethanol modifies the actin cytoskeleton in rat pancreatic acinar cells--comparison with effects of CCK. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20040101
Assessment of PC12 cell differentiation and neurite growth: a comparison of morphological and neurochemical measures. Neurotoxicology and teratology 20040101
Signal transduction pathway in endothelial dysfunction. Surgical infections 20040101
Neurokinin-1 receptors in the rat nucleus tractus solitarius: pre- and postsynaptic modulation of glutamate and GABA release. Neuroscience 20040101
Role of protein kinase C-dependent signaling pathways in the antiangiogenic properties of nafoxidine. Anticancer research 20040101
Glycated albumin induces superoxide generation in mesangial cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20040101
Effect of epinephrine on alpha-methyl-D-glucopyranoside uptake in renal proximal tubule cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20040101
N-methyl-D-aspartate receptors enhance mechanical responses and voltage-dependent Ca2+ channels in rat dorsal root ganglia neurons through protein kinase C. Neuroscience 20040101
Opioid modulation of GABA release in the rat inferior colliculus. BMC neuroscience 20040101
Role of reactive oxygen species in bradykinin-induced proliferation of vascular smooth muscle cells. Biological research 20040101
PAR1-type thrombin receptor stimulates migration and matrix adhesion of human colon carcinoma cells by a PKCepsilon-dependent mechanism. Oncology research 20040101
15-Deoxy-Delta12,14-prostaglandin J2 regulates endogenous Cot MAPK kinase kinase 1 activity induced by lipopolysaccharide. The Journal of biological chemistry 20031226
Induction of cIAP-2 in human colon cancer cells through PKC delta/NF-kappa B. The Journal of biological chemistry 20031219
Modulation of histamine-induced Ca2+ release by protein kinase C. Effects on cytosolic and mitochondrial [Ca2+] peaks. The Journal of biological chemistry 20031212
Gp273, the ligand molecule for sperm-egg interaction in the bivalve mollusk, Unio elongatulus, binds to and induces acrosome reaction in human spermatozoa through a protein kinase C-dependent pathway. Biology of reproduction 20031201
Alterations in rat coronary vasoreactivity and vascular protein kinase C isoforms in Type 1 diabetes. American journal of physiology. Heart and circulatory physiology 20031201
Phorbol esters and adenosine affect the readily releasable neurotransmitter pool by different mechanisms at amphibian motor nerve endings. The Journal of physiology 20031201
Transcellular signalling pathways and TNF-alpha release involved in formation of reactive oxygen species in rat alveolar macrophages exposed to tert-butylcyclohexane. Archives of toxicology 20031201
Cell surface receptors activate p21-activated kinase 1 via multiple Ras and PI3-kinase-dependent pathways. Cellular signalling 20031201
Sensitization of adenylate cyclase by short-term activation of 5-HT1A receptors. Cellular signalling 20031201
Activation of P2X7 purinoceptor-stimulated TGF-beta 1 mRNA expression involves PKC/MAPK signalling pathway in a rat brain-derived type-2 astrocyte cell line, RBA-2. Cellular signalling 20031201
1,10-Phenanthroline phosphorylates (activates) MAP kinase in Xenopus oocytes. Cellular signalling 20031201
Possible role of the protein kinase C/CPI-17 pathway in the augmented contraction of human myometrium after gestation. British journal of pharmacology 20031201
Mechanism of the positive contractile effect of nitric oxide on rat ventricular cardiomyocytes with positive force/frequency relationship. Pflugers Archiv : European journal of physiology 20031201
The PLC-PKC cascade is required for IL-1beta-dependent Erk and Akt activation: their role in proliferation. International journal of oncology 20031201
The diacylglycerol and protein kinase C pathways are not involved in insulin signalling in primary rat hepatocytes. European journal of biochemistry 20031201
Edaravone, a radical scavenger, may enhance or produce antiproliferative effects of fluvastatin, amlodipine, ozagrel, GF109203X and Y27632 on cultured basilar artery smooth muscle cells. Biological & pharmaceutical bulletin 20031201
The expression of retinoblastoma and Sp1 is increased by low concentrations of cyclin-dependent kinase inhibitors. European journal of biochemistry 20031201
Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory. Journal of neurochemistry 20031201
Intracellular proteins involved in Porphyromonas gingivalis-induced opsonophagocytic activities of a murine macrophage cell line (RAW264.7 cells). Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 20031201
Defective human MutY phosphorylation exists in colorectal cancer cell lines with wild-type MutY alleles. The Journal of biological chemistry 20031128
Human glycated albumin affects glucose metabolism in L6 skeletal muscle cells by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase C alpha-mediated mechanism. The Journal of biological chemistry 20031128
Protein kinase C-beta-mediated complex formation between tyrosinase and TRP-1. Biochemical and biophysical research communications 20031128
The synergistic activation of Raf-1 kinase by phorbol myristate acetate and hydrogen peroxide in NIH3T3 cells. Biochemical and biophysical research communications 20031128
Regulated cell surface pro-EGF ectodomain shedding is a zinc metalloprotease-dependent process. The Journal of biological chemistry 20031114
Protein kinase C modulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by targeting the apical events of death receptor signaling. The Journal of biological chemistry 20031107
Stearic acid facilitates hippocampal neurotransmission by enhancing nicotinic ACh receptor responses via a PKC pathway. Brain research. Molecular brain research 20031106
Monochloramine induces reorganization of nuclear speckles and phosphorylation of SRp30 in human colonic epithelial cells: role of protein kinase C. American journal of physiology. Cell physiology 20031101
PKC epsilon is involved in JNK activation that mediates LPS-induced TNF-alpha, which induces apoptosis in macrophages. American journal of physiology. Cell physiology 20031101
Parathyroid hormone-related protein(1-34) regulates Phex expression in osteoblasts through the protein kinase A pathway. Endocrinology 20031101
Bacterial lipopolysaccharide modulates protein kinase C signalling in Lymnaea stagnalis haemocytes. Biology of the cell 20031101
Proteasome inhibition induces nuclear translocation of the dioxin receptor through an Sp1 and protein kinase C-dependent pathway. Journal of molecular biology 20031017
Thromboxane A2-induced inhibition of voltage-gated K+ channels and pulmonary vasoconstriction: role of protein kinase Czeta. Circulation research 20031003
Inhibition of protein kinase Calpha enhances anticancer agent-induced loss of anchorage-independent growth regardless of protection against apoptosis by Bcl-2. Molecular pharmacology 20031001
Adenosine-induced IL-6 expression in pituitary folliculostellate cells is mediated via A2b adenosine receptors coupled to PKC and p38 MAPK. British journal of pharmacology 20031001
Substance P protects spiral ganglion neurons from apoptosis via PKC-Ca2+-MAPK/ERK pathways. Journal of neurochemistry 20031001
Arsenite stimulated glucose transport in 3T3-L1 adipocytes involves both Glut4 translocation and p38 MAPK activity. European journal of biochemistry 20031001
Bisindolylmaleimide IX is a potent inducer of apoptosis in chronic lymphocytic leukaemic cells and activates cleavage of Mcl-1. Leukemia 20031001
Thrombin induces neoangiogenesis in the chick chorioallantoic membrane. Journal of thrombosis and haemostasis : JTH 20031001
A1 adenosine receptors accumulate in neurodegenerative structures in Alzheimer disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation. Brain pathology (Zurich, Switzerland) 20031001
Regulation of uterine hsp90alpha, hsp72 and HSF-1 transcription in B6C3F1 mice by beta-estradiol and bisphenol A: involvement of the estrogen receptor and protein kinase C. Toxicology letters 20030930
Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin. The Journal of biological chemistry 20030926
The expression of a high level of morphine antinociceptive tolerance in mice involves both PKC and PKA. Brain research 20030919
Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3. Bioorganic & medicinal chemistry letters 20030915
Agonist function of the neurokinin receptor antagonist, [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, in monocytes. Regulatory peptides 20030915
Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways. Blood 20030901
20-HETE inotropic effects involve the activation of a nonselective cationic current in airway smooth muscle. American journal of physiology. Lung cellular and molecular physiology 20030901
Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor. The Journal of physiology 20030901
ATP augments peptide release from rat sensory neurons in culture through activation of P2Y receptors. The Journal of pharmacology and experimental therapeutics 20030901
Acylation stimulating protein stimulates insulin secretion. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 20030901
B cell receptor signaling mediates immediate protection from Fas-induced apoptosis upstream of caspase activation through an atypical protein kinase C isozyme and de novo protein synthesis. European journal of immunology 20030901
Effect of ATP on Ca2+ uptake in the presence of high glucose in renal proximal tubule cells. Clinical and experimental pharmacology & physiology 20030901
Inhibition of protein kinase C reduces ischemia-induced tyrosine phosphorylation of the N-methyl-d-aspartate receptor. Journal of neurochemistry 20030901
A novel potential therapy for diabetic nephropathy and vascular complications: protein kinase C beta inhibition. American journal of kidney diseases : the official journal of the National Kidney Foundation 20030901
Busulfan induces activin A expression in vitro and in vivo: a possible link to venous occlusive disease. Clinical pharmacology and therapeutics 20030901
Protein kinase C-mediated Ca2+ entry in HEK 293 cells transiently expressing human TRPV4. British journal of pharmacology 20030901
Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation. British journal of pharmacology 20030901
Distinct mechanisms mediate the initial and sustained phases of cell migration in epidermal growth factor receptor-overexpressing cells. Molecular cancer research : MCR 20030901
Differential effects of calmodulin and protein kinase C antagonists on bone resorption and acid transport activity. Calcified tissue international 20030901
Differential signalling by muscarinic receptors in smooth muscle: m2-mediated inactivation of myosin light chain kinase via Gi3, Cdc42/Rac1 and p21-activated kinase 1 pathway, and m3-mediated MLC20 (20 kDa regulatory light chain of myosin II) phosphorylation via Rho-associated kinase/myosin phosphatase targeting subunit 1 and protein kinase C/CPI-17 pathway. The Biochemical journal 20030815
Asbestos-induced apoptosis is protein kinase C delta-dependent. American journal of respiratory cell and molecular biology 20030801
Protein kinase C controls microtubule-based traffic but not proteasomal degradation of c-Met. The Journal of biological chemistry 20030801
Mediation of corticotropin releasing factor type 1 receptor phosphorylation and desensitization by protein kinase C: a possible role in stress adaptation. The Journal of pharmacology and experimental therapeutics 20030801
Contractions activate hormone-sensitive lipase in rat muscle by protein kinase C and mitogen-activated protein kinase. The Journal of physiology 20030801
Rottlerin, an inhibitor of protein kinase Cdelta (PKCdelta), inhibits astrocytic glutamate transport activity and reduces GLAST immunoreactivity by a mechanism that appears to be PKCdelta-independent. Journal of neurochemistry 20030801
Human beta(3)-adrenoreceptors couple to KvLQT1/MinK potassium channels in Xenopus oocytes via protein kinase C phosphorylation of the KvLQT1 protein. Naunyn-Schmiedeberg's archives of pharmacology 20030801
Mechanism of the negative inotropic effects of alpha 1-adrenoceptor agonists on mouse myocardium. Canadian journal of physiology and pharmacology 20030801
Enhancement of aminopeptidase A expression during angiotensin II-induced choriocarcinoma cell proliferation through AT1 receptor involving protein kinase C- and mitogen-activated protein kinase-dependent signaling pathway. The Journal of clinical endocrinology and metabolism 20030801
Agonist-independent desensitization and internalization of the human platelet-activating factor receptor by coumermycin-gyrase B-induced dimerization. The Journal of biological chemistry 20030725
Excitatory effects of orexin-A on nucleus tractus solitarius neurons are mediated by phospholipase C and protein kinase C. The Journal of neuroscience : the official journal of the Society for Neuroscience 20030716
Ca(2+)-independent protein kinase C activity is required for alpha1-adrenergic-receptor-mediated regulation of ribosomal protein S6 kinases in adult cardiomyocytes. The Biochemical journal 20030715
Regulation of hyaluronan secretion into rabbit synovial joints in vivo by protein kinase C. The Journal of physiology 20030715
Protein kinase C beta is required for human monocyte chemotaxis to MCP-1. The Journal of biological chemistry 20030711
Positive inotropic effect of endothelin-1 in the neonatal mouse right ventricle. European journal of pharmacology 20030711
Physical and functional interaction between protein kinase C delta and Fyn tyrosine kinase in human platelets. The Journal of biological chemistry 20030704
Protein kinase C is involved in neurokinin receptor modulation of N- and L-type Ca2+ channels in DRG neurons of the adult rat. Journal of neurophysiology 20030701
Protein kinase C is involved in 2B4 (CD244)-mediated cytotoxicity and AP-1 activation in natural killer cells. Immunology 20030701
Recovery of gap junctional intercellular communication after phorbol ester treatment requires proteasomal degradation of protein kinase C. Carcinogenesis 20030701
Phospholipase C and protein kinase C involvement in mouse embryonic stem-cell proliferation and apoptosis. Reproduction (Cambridge, England) 20030701
The inhibitory effects of ketamine and pentobarbital on substance p receptors expressed in Xenopus oocytes. Anesthesia and analgesia 20030701
Role of protein kinase C, Ca2+/calmodulin-dependent protein kinase II, and mitogen-activated protein kinases in volatile anesthetic-induced relaxation in newborn rabbit pulmonary artery. Anesthesiology 20030701
Endothelin-1 inhibits TNF alpha-induced iNOS expression in 3T3-F442A adipocytes. British journal of pharmacology 20030701
Hydrogen peroxide inhibits insulin signaling in vascular smooth muscle cells. Experimental biology and medicine (Maywood, N.J.) 20030701
New evidence on the mechanisms underlying bradykinin-mediated contraction of the pig iris sphincter in vitro. Peptides 20030701
High glucose potentiates palmitate-induced NO-mediated cytotoxicity through generation of superoxide in clonal beta-cell HIT-T15. FEBS letters 20030619
Modification of intracellular free calcium in cultured A10 vascular smooth muscle cells by exogenous phosphatidic acid. Biochemical pharmacology 20030615
Astrocyte stellation induced by Rho kinase inhibitors in culture. Brain research. Developmental brain research 20030612
Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCbeta. Bioorganic & medicinal chemistry letters 20030602
Urocortin-related peptides increase interleukin-6 output via cyclic adenosine 5'-monophosphate-dependent pathways in A7r5 aortic smooth muscle cells. Endocrinology 20030601
Vitamin D enhances mitogenesis mediated by keratinocyte growth factor receptor in keratinocytes. Journal of cellular biochemistry 20030601
Propofol increases phosphorylation of troponin I and myosin light chain 2 via protein kinase C activation in cardiomyocytes. Anesthesiology 20030601
Modulation of Ca2+ sensitivity regulates contractility of rabbit corpus cavernosum smooth muscle. The Journal of urology 20030601
An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. The Journal of clinical investigation 20030601
Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1). Journal of molecular endocrinology 20030601
Cocaine produces cardiac hypertrophy by protein kinase C dependent mechanisms. Journal of cardiovascular pharmacology and therapeutics 20030601
An absolute role of the PKC-dependent NF-kappaB activation for induction of MMP-9 in hepatocellular carcinoma cells. Biochemical and biophysical research communications 20030530
Suppression of lipopolysaccharide-dependent tumor necrosis factor alpha induction in rat microglia, in which protein kinase C alpha is down-regulated. Neuroscience letters 20030529
Growth hormone-induced phosphorylation of epidermal growth factor (EGF) receptor in 3T3-F442A cells. Modulation of EGF-induced trafficking and signaling. The Journal of biological chemistry 20030523
Incadronate amplifies prostaglandin F2 alpha-induced vascular endothelial growth factor synthesis in osteoblasts. Enhancement of MAPK activity. The Journal of biological chemistry 20030523
Phosphospecific site tyrosine phosphorylation of p125FAK and proline-rich kinase 2 is differentially regulated by cholecystokinin receptor type A activation in pancreatic acini. The Journal of biological chemistry 20030523
Evidence for the involvement of a phospholipase C--protein kinase C signaling pathway in insulin stimulated glucose transport in skeletal muscle. Life sciences 20030523
Characterization of bradykinin-induced prostaglandin E2 release from cultured rat trigeminal ganglion neurones. European journal of pharmacology 20030523
Interferon-gamma stimulates the expression of the inducible cAMP early repressor in macrophages through the activation of casein kinase 2. A potentially novel pathway for interferon-gamma-mediated inhibition of gene transcription. The Journal of biological chemistry 20030516
Signal transduction and Ca2+ signaling in contractile regulation induced by crosstalk between endothelin-1 and norepinephrine in dog ventricular myocardium. Circulation research 20030516
Protein kinase Calpha activation by RET: evidence for a negative feedback mechanism controlling RET tyrosine kinase. Oncogene 20030515
The role of several kinases in mice tolerant to delta 9-tetrahydrocannabinol. The Journal of pharmacology and experimental therapeutics 20030501
LOX-1, an oxidized LDL endothelial receptor, induces CD40/CD40L signaling in human coronary artery endothelial cells. Arteriosclerosis, thrombosis, and vascular biology 20030501
PLIF induces IL-10 production in monocytes: a calmodulin-p38 mitogen-activated protein kinase-dependent pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030501
Neuroprotection and neurorescue against Abeta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol (-)-epigallocatechin-3-gallate. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030501
Adenosine A2A receptor-mediated facilitation of noradrenaline release involves protein kinase C activation and attenuation of presynaptic inhibitory receptor-mediated effects in the rat vas deferens. Journal of neurochemistry 20030501
Allyl alcohol activation of protein kinase C delta leads to cytotoxicity of rat hepatocytes. Chemical research in toxicology 20030501
Distinct protein kinase C isoforms mediate regulation of vascular endothelial growth factor expression by A2A adenosine receptor activation and phorbol esters in pheochromocytoma PC12 cells. The Journal of biological chemistry 20030425
BCR targets cyclin D2 via Btk and the p85alpha subunit of PI3-K to induce cell cycle progression in primary mouse B cells. Oncogene 20030417
Involvement of MEKK1/ERK/P21Waf1/Cip1 signal transduction pathway in inhibition of IGF-I-mediated cell growth response by methylglyoxal. Journal of cellular biochemistry 20030415
Oleic acid induces endothelin-1 expression through activation of protein kinase C and NF-kappa B. Biochemical and biophysical research communications 20030411
Chelerythrine and bisindolylmaleimide I prolong cardiac action potentials by protein kinase C-independent mechanism. European journal of pharmacology 20030411
Kinase inhibitors: not just for kinases anymore. Journal of medicinal chemistry 20030410
Effects of hypoxia on rat airway smooth muscle cell proliferation. Journal of applied physiology (Bethesda, Md. : 1985) 20030401
Nongenomic effect of aldosterone on Na+,K+-adenosine triphosphatase in arterial vessels. Endocrinology 20030401
Mechanism of action of Gq to inhibit G beta gamma modulation of CaV2.2 calcium channels: probed by the use of receptor-G alpha tandems. Molecular pharmacology 20030401
Roles of protein kinase A and C in the opioid potentiation of the GABAA response in rat periaqueductal gray neuron. Neuropharmacology 20030401
Substance P modulates localized calcium transients and membrane current responses in murine colonic myocytes. British journal of pharmacology 20030401
The vasoactive peptide urotensin II stimulates spontaneous release from frog motor nerve terminals. British journal of pharmacology 20030401
Effect of protein kinase C activation and inhibition on rat hepatic stellate cell activation. Digestive diseases and sciences 20030401
Prostaglandin F(2alpha) stimulation of cyclooxygenase-2 promoter activity by the FP(B) prostanoid receptor. European journal of pharmacology 20030328
Role of Na+/H+ exchanger in acetylcholine-mediated pulmonary artery contraction of spontaneously hypertensive rats. European journal of pharmacology 20030319
Protein kinase C is necessary for recovery from the thyrotropin-releasing hormone-induced r-ERG current reduction in GH3 rat anterior pituitary cells. The Journal of physiology 20030315
Protein kinase C mediates translocation of type II phosphatidylinositol 5-phosphate 4-kinase required for platelet alpha-granule secretion. The Journal of biological chemistry 20030307
Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle. Circulation research 20030307
Mechanisms regulating the cadmium-mediated suppression of Sp1 transcription factor activity in alveolar epithelial cells. Toxicology 20030303
Erk1/2- and p38 MAP kinase-dependent phosphorylation and activation of cPLA2 by m3 and m2 receptors. American journal of physiology. Gastrointestinal and liver physiology 20030301
Vitamin D receptor is not required for the rapid actions of 1,25-dihydroxyvitamin D3 to increase intracellular calcium and activate protein kinase C in mouse osteoblasts. Journal of cellular biochemistry 20030301
Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes. Diabetes 20030301
Facilitation of fas mediated apoptosis of human chondrocytes by the proteasome inhibitor and actinomycin D. The Journal of rheumatology 20030301
Suppression of TNF-alpha mediated apoptosis by EGF in TNF-alpha sensitive human cervical carcinoma cell line. Growth factors (Chur, Switzerland) 20030301
Protein kinase C-epsilon protects PC12 cells against methamphetamine-induced death: possible involvement of suppression of glutamate receptor. Life sciences 20030221
Tensile stress-dependent collagen XII and fibronectin production by fibroblasts requires separate pathways. Biochimica et biophysica acta 20030217
Synaptic Drosophila UNC-13 is regulated by antagonistic G-protein pathways via a proteasome-dependent degradation mechanism. Journal of neurobiology 20030215
A parallel signal-transduction pathway for eotaxin- and interleukin-5-induced eosinophil shape change. Immunology 20030201
Phosphorylation of the myosin phosphatase targeting subunit and CPI-17 during Ca2+ sensitization in rabbit smooth muscle. The Journal of physiology 20030201
Metabotropic glutamate receptors activate phospholipase D in astrocytes through a protein kinase C-dependent and Rho-independent pathway. Neuropharmacology 20030201
The forskolin-induced opening of tight junctions in Xenopus gallbladder epithelium is mediated by protein kinase C. Cellular and molecular biology (Noisy-le-Grand, France) 20030201
Thrombin rapidly induces protein kinase D phosphorylation, and protein kinase C delta mediates the activation. The Journal of biological chemistry 20030131
Activation of microglia with lipopolysaccharide leads to the prolonged decrease of conventional protein kinase C activity. Brain research. Molecular brain research 20030131
Activation of RAF-1 through Ras and protein kinase Calpha mediates 1alpha,25(OH)2-vitamin D3 regulation of the mitogen-activated protein kinase pathway in muscle cells. The Journal of biological chemistry 20030124
Corticotropin-releasing factor receptors couple to multiple G-proteins to activate diverse intracellular signaling pathways in mouse hippocampus: role in neuronal excitability and associative learning. The Journal of neuroscience : the official journal of the Society for Neuroscience 20030115
The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2. The Journal of biological chemistry 20030103
VEGF increases endothelial permeability by separate signaling pathways involving ERK-1/2 and nitric oxide. American journal of physiology. Heart and circulatory physiology 20030101
Protein kinase C activity, translocation, and selective isoform subcellular redistribution in the rat cerebral cortex after in vitro ischemia. Journal of neuroscience research 20030101
Role of protein kinase C-angiotensin II pathway for extracellular matrix production in cultured human mesangial cells exposed to high glucose levels. Diabetes research and clinical practice 20030101
Bryostatin 1 and UCN-01 potentiate 1-beta-D-arabinofuranosylcytosine-induced apoptosis in human myeloid leukemia cells through disparate mechanisms. Molecular pharmacology 20030101
Temporal regulation of agonist efficacy at 5-hydroxytryptamine (5-HT)1A and 5-HT 1B receptors. The Journal of pharmacology and experimental therapeutics 20030101
ETA, mixed ETA/ETB receptor antagonists, and protein kinase C inhibitor prevent acute hypoxic pulmonary vasoconstriction: influence of potassium channels. Journal of cardiovascular pharmacology 20030101
[G-protein-coupled muscarinic acetylcholine receptor activation up-regulates Bcl-2 and phospho-bad via Ras-ERK-1/2 signaling pathway]. Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica 20030101
Alpha 1-adrenoceptor effects mediated by protein kinase C alpha in human cultured prostatic stromal cells. British journal of pharmacology 20030101
Protein kinase C-epsilon is involved in the adenosine-activated signal transduction pathway conferring protection against ischemia-reperfusion injury in primary rat neuronal cultures. Journal of neurochemistry 20030101
The role of protein kinase C in modulation of aqueous humor outflow facility. Experimental eye research 20030101
The expression of growth hormone-releasing hormone (GHRH) and its receptor splice variants in human breast cancer lines; the evaluation of signaling mechanisms in the stimulation of cell proliferation. Breast cancer research and treatment 20030101
Preventing superoxide formation in epineurial arterioles of the sciatic nerve from diabetic rats restores endothelium-dependent vasodilation. Free radical research 20030101
A protein kinase Cbeta inhibitor attenuates multidrug resistance of neuroblastoma cells. BMC cancer 20030101
Induction of early growth response gene Egr2 by basic calcium phosphate crystals through a calcium-dependent protein kinase C-independent p44/42 mitogen-activated protein kinase pathway. Cells, tissues, organs 20030101
Phorbol myristate acetate and Bryostatin 1 rescue IFN-gamma inducibility of MHC class II molecules in LS1034 colorectal carcinoma cell line. Cancer cell international 20030101
Bisindolylmaleimide IX Induces Reversible and Time-Dependent Tumor Necrosis Factor Receptor Family-Mediated Caspase Activation and Cell Death. Cancer biology & therapy 20030101
Death ligands and bisindolylmaleimide: a killer combination. Cancer biology & therapy 20030101
Epidermal growth factor regulates Ca2+ uptake in primary cultured renal proximal tubule cells: involvement of cAMP, PKC and cPLA2. Kidney & blood pressure research 20030101
Pro-inflammatory cytokine-induced matrix metalloproteinase-1 (MMP-1) secretion in human pancreatic periacinar myofibroblasts. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20030101
Pityrialactone- a new fluorochrome from the tryptophan metabolism of Malassezia furfur. Antonie van Leeuwenhoek 20030101
Effect of epidermal growth factor on phosphate uptake in renal proximal tubule cells: involvement of PKC, MAPK, and cPLA2. Kidney & blood pressure research 20030101
Hyperglycemia-induced protein kinase C activation inhibits phagocytosis of C3b- and immunoglobulin g-opsonized yeast particles in normal human neutrophils. Experimental diabesity research 20030101
Endothelial NADPH oxidase: mechanism of activation by low-density lipoprotein. Endothelium : journal of endothelial cell research 20030101
Regulation of Na(+)-K(+)-2Cl- cotransporter activity in rat skeletal muscle and intestinal epithelial cells. Tsitologiia 20030101
Role of the flocculus in mediating vestibular nucleus neuron plasticity during vestibular compensation in the rat. The Journal of physiology 20021215
Ca2+-stimulated Ca2+ oscillations produced by the Ca2+-sensing receptor require negative feedback by protein kinase C. The Journal of biological chemistry 20021206
alpha1B-Adrenergic receptor phosphorylation and desensitization induced by transforming growth factor-beta. The Biochemical journal 20021201
Protein kinase G activation of K(ATP) channels in human-cultured prostatic stromal cells. Cellular signalling 20021201
Regulation of volume-sensitive outwardly rectifying anion channels in pulmonary arterial smooth muscle cells by PKC. American journal of physiology. Cell physiology 20021201
Smooth muscle cells contract in response to fluid flow via a Ca2+-independent signaling mechanism. Journal of applied physiology (Bethesda, Md. : 1985) 20021201
RhoA kinase and protein kinase C participate in regulation of rabbit stomach fundus smooth muscle contraction. British journal of pharmacology 20021201
Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: role of PI3K, PKC and PLC pathways. British journal of pharmacology 20021201
Calcium and protein kinase C (PKC)-related kinase mediate alpha 1A-adrenergic receptor-stimulated activation of phospholipase D in rat-1 cells, independent of PKC. The Journal of pharmacology and experimental therapeutics 20021201
Latanoprost's effects on TIMP-1 and TIMP-2 expression in human ciliary muscle cells. Investigative ophthalmology & visual science 20021201
Role of specific protein kinase C isozymes in mediating epidermal growth factor, thyrotropin-releasing hormone, and phorbol ester regulation of the rat prolactin promoter in GH4/GH4C1 pituitary cells. Molecular endocrinology (Baltimore, Md.) 20021201
Propofol increases pulmonary artery smooth muscle myofilament calcium sensitivity: role of protein kinase C. Anesthesiology 20021201
2-Nicotinamidoethyl nitrale (2-NN) protects myocardium in ischemia and reperfusion via the protein kinase C pathway. The Journal of cardiovascular surgery 20021201
Activation of protein kinase C triggers irreversible cell cycle withdrawal in human keratinocytes. The Journal of investigative dermatology 20021201
Acute-phase, but not constitutive serum amyloid A (SAA) is chemotactic for cultured human aortic smooth muscle cells. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 20021201
Phospholipase C axis is the preferential pathway leading to PKC activation following PTH or PTHrP stimulation in human term placenta. Life sciences 20021129
Glucose upregulates plasminogen activator inhibitor-1 gene expression in vascular smooth muscle cells. Life sciences 20021122
Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein. The Biochemical journal 20021115
Protein kinase C inhibitors counteract the ethanol effects on myelin basic protein expression in differentiating CG-4 oligodendrocytes. Brain research. Developmental brain research 20021115
Serotonin-induced MMP-13 production is mediated via phospholipase C, protein kinase C, and ERK1/2 in rat uterine smooth muscle cells. The Journal of biological chemistry 20021108
Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021101
Calcium-sensing receptor-mediated TNF production in medullary thick ascending limb cells. American journal of physiology. Renal physiology 20021101
Critical role of protein kinase C epsilon for lipopolysaccharide-induced IL-12 synthesis in monocyte-derived dendritic cells. European journal of immunology 20021101
The inhibitory effects of tramadol on muscarinic receptor-induced responses in Xenopus oocytes expressing cloned M(3) receptors. Anesthesia and analgesia 20021101
Transducing system operated by adenosine A(2A) receptors to facilitate acetylcholine release in the rat hippocampus. European journal of pharmacology 20021101
Bisindolylmaleimide I and V inhibit necrosis induced by oxidative stress in a variety of cells including neurons. Neuroscience research 20021101
Urotensin-II regulates intracellular calcium in dissociated rat spinal cord neurons. Journal of neurochemistry 20021101
Desnitro-imidacloprid activates the extracellular signal-regulated kinase cascade via the nicotinic receptor and intracellular calcium mobilization in N1E-115 cells. Toxicology and applied pharmacology 20021101
Factors contributing to neurotrophin-independent survival of adult sensory neurons. Brain research 20021025
Calmodulin prevents activation of Ras by PKC in 3T3 fibroblasts. The Journal of biological chemistry 20021004
Involvement of MAP kinase in the regulation of amyloid precursor protein processing by novel cholinesterase inhibitors derived from rasagiline. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021001
Characterization of a Na(+)-Ca(2+) exchanger in podocytes. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20021001
IL-1 beta potentiates heat-activated currents in rat sensory neurons: involvement of IL-1RI, tyrosine kinase, and protein kinase C. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021001
Activation of proteinase-activated receptor 1 stimulates epithelial chloride secretion through a unique MAP kinase- and cyclo-oxygenase-dependent pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021001
PKC-dependent IL-6 production and inhibition of IL-8 production by PKC activation in normal human skin fibroblasts under extremely high hydrostatic pressure. Extremophiles : life under extreme conditions 20021001
Brief, repeated exposure to substrates down-regulates dopamine transporter function in Xenopus oocytes in vitro and rat dorsal striatum in vivo. Journal of neurochemistry 20021001
MAP kinase signaling cascade dysfunction specific to Alzheimer's disease in fibroblasts. Neurobiology of disease 20021001
Serotonin potentiation of glycine-activated whole-cell currents in the superficial laminae neurons of the rat spinal dorsal horn is mediated by protein kinase C. Brain research bulletin 20020930
Protein kinase C mediates potentiation of synaptic transmission by phorbol ester at parallel fibers in the dorsal cochlear nucleus. Brain research 20020927
Protein kinase C(alpha) is required for vanilloid receptor 1 activation. Evidence for multiple signaling pathways. The Journal of biological chemistry 20020920
Inhibition by Wnt-1 or Wnt-3a of nerve growth factor-induced differentiation of PC12 cells is reversed by bisindolylmaleimide-I but not by several other PKC inhibitors. Oncogene 20020912
Phorbol 12-myristate 13-acetate up-regulates the transcription of MUC2 intestinal mucin via Ras, ERK, and NF-kappa B. The Journal of biological chemistry 20020906
Bisindolylmaleimide IX facilitates tumor necrosis factor receptor family-mediated cell death and acts as an inhibitor of transcription. The Journal of biological chemistry 20020906
Angiotensin II stimulation of NAD(P)H oxidase activity: upstream mediators. Circulation research 20020906
Biphasic regulation of plasminogen activator/inhibitor by LDL in mesangial cells. American journal of physiology. Renal physiology 20020901
Role of protein phosphatases in hypoxic preconditioning. American journal of physiology. Heart and circulatory physiology 20020901
Characterization of the anandamide induced depolarization of guinea-pig isolated vagus nerve. British journal of pharmacology 20020901
Protein kinase C-epsilon mediates bradykinin-induced cyclooxygenase-2 expression in human airway smooth muscle cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020901
PACAP potentiates L-type calcium channel conductance in suprachiasmatic nucleus neurons by activating the MAPK pathway. Journal of neurophysiology 20020901
Regulation of ionomycin-mediated granule release from rat basophil leukemia cells. Molecular immunology 20020901
Dipyridamole inhibits in vitro renal fibroblast proliferation and collagen synthesis. The Journal of laboratory and clinical medicine 20020901
Picrosides I and II, selective enhancers of the mitogen-activated protein kinase-dependent signaling pathway in the action of neuritogenic substances on PC12D cells. Life sciences 20020830
Potentiation of tumor necrosis factor-alpha-induced cell death by rottlerin through a cytochrome-C-independent pathway. Experimental cell research 20020815
Excitation of smooth muscles isolated from the guinea-pig gastric antrum in response to depolarization. The Journal of physiology 20020815
Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways. The Journal of biological chemistry 20020809
Alteration of cellular phosphorylation state affects vitamin D receptor-mediated CYP3A4 mRNA induction in Caco-2 cells. Biochemical and biophysical research communications 20020809
Phosphorylation and activation of mitogen- and stress-activated protein kinase-1 in adult rat cardiac myocytes by G-protein-coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase. The Biochemical journal 20020801
Protein kinase C regulates endocytosis and recycling of E-cadherin. American journal of physiology. Cell physiology 20020801
Stimulation of protein kinase C pathway mediates endocytosis of human nongastric H+-K+-ATPase, ATP1AL1. American journal of physiology. Renal physiology 20020801
Acid- and bile-induced PGE(2) release and hyperproliferation in Barrett's esophagus are COX-2 and PKC-epsilon dependent. American journal of physiology. Gastrointestinal and liver physiology 20020801
Phorbol ester-induced contractility and Ca2+ influx in human cultured prostatic stromal cells. Biochemical pharmacology 20020801
Regulation of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in thyroid carcinoma cells. The American journal of pathology 20020801
Inhibition of protein kinases A and C demonstrates dual modes of response in human eosinophils stimulated with platelet-activating factor. The Journal of allergy and clinical immunology 20020801
Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells. The Journal of endocrinology 20020801
Amine fluoride gel affects the viability and the generation of superoxide anions in human polymorphonuclear leukocytes: an in vitro study. European journal of oral sciences 20020801
Investigation of the mechanisms of G protein: effector coupling by the human and mouse prostacyclin receptors. Identification of critical species-dependent differences. The Journal of biological chemistry 20020726
Effect of Cu,Zn superoxide dismutase on cholesterol metabolism in human hepatocarcinoma (HepG2) cells. Biochemical and biophysical research communications 20020719
Superoxide anion-dependent Raf/MEK/ERK activation by peroxisome proliferator activated receptor gamma agonists 15-deoxy-delta(12,14)-prostaglandin J(2), ciglitazone, and GW1929. Experimental cell research 20020715
Induction of cyclooxygenase-2 by staurosporine through the activation of nuclear factor for IL-6 (NF-IL6) and activator protein 2 (AP2) in an osteoblast-like cell line. Biochemical pharmacology 20020715
Mobilization of intracellular calcium in kidney epithelial cells is inhibited by lead. Toxicology 20020701
Putative conventional protein kinase C inhibitor Gödecke 6976 [12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole] stimulates transglutaminase activity in primary mouse epidermal keratinocytes. The Journal of pharmacology and experimental therapeutics 20020701
Phorbol myristate acetate induces ruffling of the acrosome of human sperm. Fertility and sterility 20020701
Different actions of protein kinase C isoforms alpha and epsilon on gastric acid secretion. British journal of pharmacology 20020701
Dopamine transporter-dependent induction of C-Fos in HEK cells. Synapse (New York, N.Y.) 20020701
Mechanisms involved in responses to the poroxisome proliferator WY-14,643 on gap junctional intercellular communication in V79 hamster fibroblasts. Toxicology and applied pharmacology 20020701
Ca(2+)-calmodulin-dependent protein kinase II plays a major role in halothane-induced dose-dependent relaxation in the skinned pulmonary artery. Anesthesiology 20020701
Cerebrovascular alterations in pressure and protein kinase C-mediated constriction in Dahl salt-sensitive rats. Journal of hypertension 20020701
Angiotensin II inhibits renin gene transcription via the protein kinase C pathway. Pflugers Archiv : European journal of physiology 20020701
Neutral endopeptidase/CD10 expression during phorbol ester-induced differentiation of choriocarcinoma cells through the protein kinase C- and extracellular signal-regulated kinase-dependent signalling pathway. Placenta 20020701
The Golgi localization of phosphatidylinositol transfer protein beta requires the protein kinase C-dependent phosphorylation of serine 262 and is essential for maintaining plasma membrane sphingomyelin levels. The Journal of biological chemistry 20020621
Increase in the pool size of releasable synaptic vesicles by the activation of protein kinase C in goldfish retinal bipolar cells. The Journal of neuroscience : the official journal of the Society for Neuroscience 20020615
Glucose transport rate and glycogen synthase activity both limit skeletal muscle glycogen accumulation. American journal of physiology. Endocrinology and metabolism 20020601
Regulation and function of COX-2 gene expression in isolated gastric parietal cells. American journal of physiology. Gastrointestinal and liver physiology 20020601
Synergistic induction of apoptosis in human myeloid leukemia cells by phorbol 12-myristate 13-acetate and flavopiridol proceeds via activation of both the intrinsic and tumor necrosis factor-mediated extrinsic cell death pathways. Molecular pharmacology 20020601
Chromaffin cell catecholamine secretion: bisindolylmaleimide compounds exhibit novel and potent antagonist effects at the nicotinic cholinergic receptor in pheochromocytoma cells. Molecular pharmacology 20020601
Temporal activation of p42/44 mitogen-activated protein kinase and c-Jun N-terminal kinase by acetaldehyde in rat hepatocytes and its loss after chronic ethanol exposure. The Journal of pharmacology and experimental therapeutics 20020601
Divergent pathways account for two distinct effects of amyloid beta peptides on exocytosis and Ca(2+) currents: involvement of ROS and NF-kappaB. Journal of neurochemistry 20020601
Amyloid precursor protein processing is separately regulated by protein kinase C and tyrosine kinase in human astrocytes. Neuroscience letters 20020524
Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling. FEBS letters 20020522
FGF-2 and TPA induce matrix metalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway. Biochemical and biophysical research communications 20020517
Blocking NF-kappaB activation in Jurkat leukemic T cells converts the survival agent and tumor promoter PMA into an apoptotic effector. Oncogene 20020509
Protein kinase C-dependent, CCAAT/enhancer-binding protein beta-mediated expression of insulin-like growth factor I gene. The Journal of biological chemistry 20020503
Dopamine activates ERKs in alveolar epithelial cells via Ras-PKC-dependent and Grb2/Sos-independent mechanisms. American journal of physiology. Lung cellular and molecular physiology 20020501
Protein overload-induced NF-kappaB activation in proximal tubular cells requires H(2)O(2) through a PKC-dependent pathway. Journal of the American Society of Nephrology : JASN 20020501
Short- and long-term influences of heavy metals on anionic drug efflux from renal proximal tubule. The Journal of pharmacology and experimental therapeutics 20020501
Metabotropic glutamate receptor 1 internalization induced by muscarinic acetylcholine receptor activation: differential dependency of internalization of splice variants on nonvisual arrestins. Molecular pharmacology 20020501
Mechanisms of amelioration of glucose-induced endothelial dysfunction following inhibition of protein kinase C in vivo. Diabetes 20020501
Priming of long-term potentiation in mouse hippocampus by corticotropin-releasing factor and acute stress: implications for hippocampus-dependent learning. The Journal of neuroscience : the official journal of the Society for Neuroscience 20020501
Adenosine induces prolonged anti-beta-adrenergic effects in guinea-pig papillary muscle. Acta physiologica Scandinavica 20020501
Regulation of a calcium-sensitive K+ channel (cIK1) by protein kinase C. The Journal of membrane biology 20020501
The inhibition of glutamate release by metabotropic glutamate receptor 7 affects both [Ca2+]c and cAMP: evidence for a strong reduction of Ca2+ entry in single nerve terminals. The Journal of biological chemistry 20020419
Activation of extracellular signal regulated protein kinase by neuropeptide Y and pancreatic polypeptide in CHO cells expressing the NPY Y(1), Y(2), Y(4) and Y(5) receptor subtypes. Regulatory peptides 20020415
Phosphorylation of the salivary Na(+)-K(+)-2Cl(-) cotransporter. American journal of physiology. Cell physiology 20020401
Regulation of extracellular signal-regulated kinase cascades by alpha- and beta-isoforms of the human thromboxane A(2) receptor. Molecular pharmacology 20020401
Involvement of protein kinase D in Fc gamma-receptor activation of the NADPH oxidase in neutrophils. The Biochemical journal 20020401
Sigma(2)-receptor regulation of dopamine transporter via activation of protein kinase C. The Journal of pharmacology and experimental therapeutics 20020401
Enhancement of HCO(3)(-) permeability across the apical membrane of bovine corneal endothelium by multiple signaling pathways. Investigative ophthalmology & visual science 20020401
Nitric oxide production by a murine macrophage cell line (RAW264.7) stimulated with lipopolysaccharide from Actinobacillus actinomycetemcomitans. Oral microbiology and immunology 20020401
D1/D5 dopamine receptors stimulate intracellular calcium release in primary cultures of neocortical and hippocampal neurons. Journal of neurophysiology 20020401
Role of protein kinase C-epsilon in the development of kappa-opioid receptor tolerance to U50,488H in rat ventricular myocytes. British journal of pharmacology 20020401
Protein kinase C-mediated translocation of secretory vesicles to plasma membrane and enhancement of neurotransmitter release from PC12 cells. The European journal of neuroscience 20020401
Bioactivity of PTH/PTHrP analogs lacking the 1-14 N-terminal domain. Molecular and cellular endocrinology 20020328
GnRH signaling pathways regulate differentially the tilapia gonadotropin subunit genes. Molecular and cellular endocrinology 20020328
Ortho-substituted polybrominated biphenyls activate respiratory burst in granulocytes from humans. Toxicology letters 20020324
High glucose-altered gene expression in mesangial cells. Actin-regulatory protein gene expression is triggered by oxidative stress and cytoskeletal disassembly. The Journal of biological chemistry 20020322
Interaction of Bruton's tyrosine kinase and protein kinase Ctheta in platelets. Cross-talk between tyrosine and serine/threonine kinases. The Journal of biological chemistry 20020322
Intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human multiple myeloma cells. Blood 20020315
Possible role of transcriptional coactivator P/CAF and nuclear acetylation in calcium-induced keratinocyte differentiation. The Journal of biological chemistry 20020308
Phosphorylation-dependent regulation of phospholipase D2 by protein kinase C delta in rat Pheochromocytoma PC12 cells. The Journal of biological chemistry 20020308
The role of protein kinase C-delta in PTH stimulation of IGF-binding protein-5 mRNA in UMR-106-01 cells. American journal of physiology. Endocrinology and metabolism 20020301
N(omega)-nitro-L-arginine inhibits inducible HSP-70 via Ca(2+), PKC, and PKA in human intestinal epithelial T84 cells. American journal of physiology. Gastrointestinal and liver physiology 20020301
Protein kinase D is a downstream target of protein kinase Ctheta. Biochemical and biophysical research communications 20020301
Inorganic lead activates the mitogen-activated protein kinase kinase-mitogen-activated protein kinase-p90(RSK) signaling pathway in human astrocytoma cells via a protein kinase C-dependent mechanism. The Journal of pharmacology and experimental therapeutics 20020301
Ketamine suppresses norepinephrine-induced inositol 1,4,5-trisphosphate formation via pathways involving protein kinase C. Anesthesia and analgesia 20020301
Propofol attenuates beta-adrenoreceptor-mediated signal transduction via a protein kinase C-dependent pathway in cardiomyocytes. Anesthesiology 20020301
1,25-Dihydroxyvitamin D3 selectively translocates PKCalpha to nuclei in ROS 17/2.8 cells. Molecular and cellular endocrinology 20020225
Insulin stimulates nitric oxide production in rat adipocytes. Biochemical and biophysical research communications 20020222
Activation of Erk1/Erk2 and transiently increased p53 levels together may account for p21 expression associated with phorbol ester-induced transient growth inhibition in HepG2 cells. Cellular signalling 20020201
Intracellular Ca(2+) modulation of ATP-sensitive K(+) channel activity in acetylcholine-induced activation of rat pancreatic beta-cells. Endocrinology 20020201
myo-Inositol 1,4,5-trisphosphate and Ca(2+)/calmodulin-dependent factors mediate transduction of compression-induced signals in bovine articular chondrocytes. The Biochemical journal 20020201
GnRH regulates early growth response protein 1 transcription through multiple promoter elements. Molecular endocrinology (Baltimore, Md.) 20020201
Insulin signaling in the transcriptional and posttranscriptional regulation of CYP2E1 expression. Hepatology (Baltimore, Md.) 20020201
Regulation of sarcolemmal Na(+)/H(+) exchange by hydrogen peroxide in adult rat ventricular myocytes. Cardiovascular research 20020201
Involvement of Rho and tyrosine kinase in angiotensin II-induced actin reorganization in mesothelial cells. European journal of pharmacology 20020201
Time-dependent potentiation of the beta-cell is a Ca2+-independent phenomenon. The Journal of endocrinology 20020201
Ceramide activates microglia to enhance the production/secretion of brain-derived neurotrophic factor (BDNF) without induction of deleterious factors in vitro. Journal of neurochemistry 20020201
Signals involved in mycobacteria-induced CXCL-8 production by human monocytes. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20020201
The aniracetam metabolite 2-pyrrolidinone induces a long-term enhancement in AMPA receptor responses via a CaMKII pathway. Brain research. Molecular brain research 20020131
The Protein-tyrosine-phosphatase SHP2 is phosphorylated on serine residues 576 and 591 by protein kinase C isoforms alpha, beta 1, beta 2, and eta. Biochemistry 20020115
Permissive effect of voltage on mGlu 7 receptor subtype signaling in neurons. The Journal of biological chemistry 20020111
Protein Kinase C is a mediator of the synthesis and secretion of osteoprotegerin in osteoblast-like cells. Biochemical and biophysical research communications 20020111
Apelin (65-77) activates extracellular signal-regulated kinases via a PTX-sensitive G protein. Biochemical and biophysical research communications 20020111
Protein kinase C induces motility of breast cancers by upregulating secretion of urokinase-type plasminogen activator through activation of AP-1 and NF-kappaB. Biochemical and biophysical research communications 20020111
Protein kinase C and the sub-sensitivity and sub-reactivity of the diabetic rat prostate gland to noradrenaline. European journal of pharmacology 20020111
Melatonin receptor activation regulates GnRH gene expression and secretion in GT1-7 GnRH neurons. Signal transduction mechanisms. The Journal of biological chemistry 20020104
Growth factor regulation of uncoupling protein-1 mRNA expression in brown adipocytes. American journal of physiology. Cell physiology 20020101
Regulation of transepithelial phosphate transport by PTH in chicken proximal tubule epithelium. American journal of physiology. Regulatory, integrative and comparative physiology 20020101
The P2X(7) receptor-mediated phospholipase D activation is regulated by both PKC-dependent and PKC-independent pathways in a rat brain-derived Type-2 astrocyte cell line, RBA-2. Cellular signalling 20020101
Abnormalities in primary granule exocytosis in neutrophils from Type I diabetic patients with nephropathy. Clinical science (London, England : 1979) 20020101
Extracellular signal-regulated kinases and g protein-coupled receptors in megakaryocytic human erythroleukemia cells: selective activation, differential regulation, and dissociation from mitogenesis. The Journal of pharmacology and experimental therapeutics 20020101
Isoflurane activates PKC and Ca(2+) -calmodulin-dependent protein kinase II via MAP kinase signaling in cultured vascular smooth muscle cells. Anesthesiology 20020101
Role of PKC in isoflurane-induced biphasic contraction in skinned pulmonary arterial strips. Anesthesiology 20020101
The inhibitory effects of anesthetics and ethanol on substance P receptors expressed in Xenopus oocytes. Anesthesia and analgesia 20020101
Protein kinase C increases 11beta-hydroxysteroid dehydrogenase oxidation and inhibits reduction in rat Leydig cells. Journal of andrology 20020101
In vivo evidence for a role of protein kinase C in peripheral nociceptive processing. British journal of pharmacology 20020101
Antiangiogenic effects of a protein kinase Cbeta-selective small molecule. Cancer chemotherapy and pharmacology 20020101
Selective induction of mitogen-activated protein kinases in human lens epithelial cells by ultraviolet radiation. Journal of biochemical and molecular toxicology 20020101
Altered dendritic development of cerebellar Purkinje cells in slice cultures from protein kinase Cgamma-deficient mice. Neuroscience 20020101
Adenosine A(2A) receptor facilitation of hippocampal synaptic transmission is dependent on tonic A(1) receptor inhibition. Neuroscience 20020101
Protein kinase C involvement in proliferation and survival of breast cancer cells. Folia histochemica et cytobiologica 20020101
p38 mitogen-activated protein kinase activation is required for thromboxane- induced contraction in perfused and pressurized rat mesenteric resistance arteries. Journal of vascular research 20020101
The central role of thromboxane and platelet activating factor receptors in ex vivo regulation of endotoxin-induced monocyte tissue factor activity in human whole blood. Journal of endotoxin research 20020101
Albumin induces NF-kappaB expression in human proximal tubule-derived cells (IHKE-1). Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20020101
The impact of phorbol ester on the regulation of amiloride-sensitive epithelial sodium channel in alveolar type ii epithelial cells. Experimental lung research 20020101
The N-formylpeptide receptor (FPR) and a second G(i)-coupled receptor mediate fMet-Leu-Phe-stimulated activation of NADPH oxidase in murine neutrophils. Cellular immunology 20020101
15-Deoxy-delta 12,14-prostaglandin J2 and thiazolidinediones activate the MEK/ERK pathway through phosphatidylinositol 3-kinase in vascular smooth muscle cells. The Journal of biological chemistry 20011228
Role of glial glutamate transporters in the facilitatory action of FK960 on hippocampal neurotransmission. Brain research. Molecular brain research 20011216
The transcription of the peroxisome proliferator-activated receptor alpha gene is regulated by protein kinase C. Toxicology letters 20011215
Insulin increases plasma membrane content and reduces phosphorylation of Na(+)-K(+) pump alpha(1)-subunit in HEK-293 cells. American journal of physiology. Cell physiology 20011201
Regulation of c-fos induction in lens epithelial cells by 12(S)HETE-dependent activation of PKC. Investigative ophthalmology & visual science 20011201
Accelerating the induction of Fas-mediated T cell apoptosis: a strategy for transplant tolerance? Clinical and experimental immunology 20011201
Macrophage migration inhibitory factor as a redox-sensitive cytokine in cardiac myocytes. Cardiovascular research 20011201
UV-induced tyrosine phosphorylation of PKC delta and promotion of apoptosis in the HaCaT cell line. Biochemical and biophysical research communications 20011130
Enhancement of phospholipase D activity by overexpression of amyloid precursor protein in P19 mouse embryonic carcinoma cells. Neuroscience letters 20011127
Pancreastatin, a chromogranin-A-derived peptide, inhibits insulin-stimulated glycogen synthesis by activating GSK-3 in rat adipocytes. Biochemical and biophysical research communications 20011123
Role of protein kinase C in opioid modulation of glycine-gated Cl(-) current in rat periaqueductal gray neuron. European journal of pharmacology 20011116
Alteration in the voltage dependence of NMDA receptor channels in rat dorsal horn neurones following peripheral inflammation. The Journal of physiology 20011115
Phosphorylation is involved in the activation of metal-regulatory transcription factor 1 in response to metal ions. The Journal of biological chemistry 20011109
Activation of PKC but not of ERK is required for vitamin E-succinate-induced apoptosis of HL-60 cells. Biochemical and biophysical research communications 20011109
Different subtypes of alpha1-adrenoceptor modulate different K+ currents via different signaling pathways in canine ventricular myocytes. The Journal of biological chemistry 20011102
Activation of protein kinase C delays apoptosis of nerve growth factor-deprived rat sympathetic neurons through a Ca(2+)-influx dependent mechanism. Neuroscience letters 20011102
TNF-alpha enhances intracellular glucocorticoid availability. FEBS letters 20011102
Inhibition of voltage-gated K(+) currents by endothelin-1 in human pulmonary arterial myocytes. American journal of physiology. Lung cellular and molecular physiology 20011101
Coupling strength between localized Ca(2+) transients and K(+) channels is regulated by protein kinase C. American journal of physiology. Cell physiology 20011101
Protein kinase C suppresses rat organic anion transporting polypeptide 1- and 2-mediated uptake. The Journal of pharmacology and experimental therapeutics 20011101
Differences in rapid desensitization of 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptor-mediated phospholipase C activation. The Journal of pharmacology and experimental therapeutics 20011101
Noradrenaline-induced increase in protein synthesis in adult rat cardiomyocytes: involvement of only alpha1A-adrenoceptors. Naunyn-Schmiedeberg's archives of pharmacology 20011101
Regulation and mechanism of L-type calcium channel activation via V1a vasopressin receptor activation in cultured cortical neurons. Neurobiology of learning and memory 20011101
Microtubule-targeting drugs induce bcl-2 phosphorylation and association with Pin1. Neoplasia (New York, N.Y.) 20011101
Synthesis and biological evaluation of novel bisindolylmaleimides that inhibit vascular endothelial cell proliferation. Bioorganic & medicinal chemistry letters 20011022
Identification of protein kinase Calpha as an essential, but not sufficient, cytosolic factor for Ca2+-induced alpha- and dense-core granule secretion in platelets. The Journal of biological chemistry 20011019
Protein kinase C regulates the phosphorylation and cellular localization of occludin. The Journal of biological chemistry 20011019
Insulin, insulin-like growth factor-I, and platelet-derived growth factor activate extracellular signal-regulated kinase by distinct pathways in muscle cells. Biochemical and biophysical research communications 20011019
Mechanisms in fluoride-induced interleukin-8 synthesis in human lung epithelial cells. Toxicology 20011015
Protein kinase c increases the apparent affinity of the release machinery to Ca2+ by enhancing the release machinery downstream of the Ca2+ sensor. The Journal of neuroscience : the official journal of the Society for Neuroscience 20011015
Agonist-induced signaling, desensitization, and internalization of a phosphorylation-deficient AT1A angiotensin receptor. The Journal of biological chemistry 20011012
Stimulatory effect of phenylephrine on the secretion of beta-endorphin from rat adrenal medulla in vitro. Autonomic neuroscience : basic & clinical 20011008
Hormone response of rodent phenylalanine hydroxylase requires HNF1 and the glucocorticoid receptor. Biochemical and biophysical research communications 20011005
Oxidant-dependent phosphorylation of p40phox in B lymphocytes. Biochemical and biophysical research communications 20011005
Inducible RGS2 is a cross-talk regulator for parathyroid hormone signaling in rat osteoblast-like UMR106 cells. Biochemical and biophysical research communications 20011005
Down-regulation of protein kinase C activity by sorbitol rapidly induces apoptosis in human gastric cancer cell lines. Apoptosis : an international journal on programmed cell death 20011001
Regulation of eosinophil function by phosphatidylinositol-specific PLC and cytosolic PLA(2). American journal of physiology. Lung cellular and molecular physiology 20011001
Regulation of phospholipase D isoenzymes by transforming Ras and atypical protein kinase C-iota. The Biochemical journal 20011001
Pulmonary artery vasoconstriction but not [Ca2+]i signal stimulated by thromboxane A2 is partially resistant to NO. Pediatric research 20011001
Adhesion of epithelial cells to fibronectin or collagen I induces alterations in gene expression via a protein kinase C-dependent mechanism. Journal of cellular physiology 20011001
Pharmacological comparison of LTB(4)-induced NADPH oxidase activation in adherent and non-adherent guinea-pig eosinophils. British journal of pharmacology 20011001
Brain-derived neurotrophic factor stimulates beta-amyloid gene promoter activity by a Ras-dependent/AP-1-independent mechanism in SH-SY5Y neuroblastoma cells. Journal of neurochemistry 20011001
Simultaneous signalling through c-mpl, c-kit and CXCR4 enhances the proliferation and differentiation of human megakaryocyte progenitors: possible roles of the PI3-K, PKC and MAPK pathways. British journal of haematology 20011001
Major vault protein is a substrate of endogenous protein kinases in CHO and PC12 cells. Biological chemistry 20011001
Protein kinase C modulates telomerase activity in human cervical cancer cells. Experimental & molecular medicine 20010930
Inhibition of the glutamate transporter EAAC1 expressed in Xenopus oocytes by phorbol esters. Brain research 20010928
Involvement of protein kinase C-delta in DNA damage-induced apoptosis. Cell death and differentiation 20010901
Short- and long-term effect of acetylcholinesterase inhibition on the expression and metabolism of the amyloid precursor protein. Molecular psychiatry 20010901
AlphaB crystallin translocation and phosphorylation: signal transduction pathways and preconditioning in the isolated rat heart. Journal of molecular and cellular cardiology 20010901
Effects of hydrogen peroxide on the transient outward current in rabbit atrial myocytes. Clinical and experimental pharmacology & physiology 20010901
Induction of B(1)-kinin receptors in vascular smooth muscle cells: cellular mechanisms of map kinase activation. Hypertension (Dallas, Tex. : 1979) 20010901
Propofol attenuates capacitative calcium entry in pulmonary artery smooth muscle cells. Anesthesiology 20010901
The protein kinase C pathway inhibits iodide uptake by calf thyroid cells via sodium potassium-adenosine triphosphatase. Thyroid : official journal of the American Thyroid Association 20010901
Rapid fusion of granules with neutrophil cell membranes in hypertensive patients may increase vascular damage. American journal of hypertension 20010901
Role of lysophosphatidylcholine in the desensitization of beta-adrenergic receptors by Ca(2+) sensitization in tracheal smooth muscle. American journal of respiratory cell and molecular biology 20010901
[The mechanism of enhanced platelet intracellular calcium mobilization stimulated by serotonin--in the pathophysiology of mood disorders]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science 20010901
Protein kinase C is involved in M1-muscarinic receptor-mediated facilitation of L-type Ca2+ channels in neurons of the major pelvic ganglion of the adult male rat. Neurochemical research 20010901
Induction of neurite outgrowth in PC12 cells by alpha -phenyl-N-tert-butylnitron through activation of protein kinase C and the Ras-extracellular signal-regulated kinase pathway. The Journal of biological chemistry 20010831
Pharmacological evidence for system-dependent involvement of protein kinase C isoenzymes in phorbol ester-suppressed gap junctional communication. Experimental cell research 20010815
Neurotrophin secretion from cultured microglia. Journal of neuroscience research 20010815
Cardioprotective effect afforded by transient exposure to phosphodiesterase III inhibitors: the role of protein kinase A and p38 mitogen-activated protein kinase. Circulation 20010807
Histamine-induced vasoconstriction involves phosphorylation of a specific inhibitor protein for myosin phosphatase by protein kinase C alpha and delta isoforms. The Journal of biological chemistry 20010803
Insulin- and glucose-induced phosphorylation of the Na(+),K(+)-adenosine triphosphatase alpha-subunits in rat skeletal muscle. Endocrinology 20010801
Activation of mitogen-activated protein kinase by muscarinic receptors in astroglial cells: role in DNA synthesis and effect of ethanol. Glia 20010801
Inorganic lead stimulates DNA synthesis in human astrocytoma cells: role of protein kinase Calpha. Journal of neurochemistry 20010801
Zn2+-induced ERK activation mediated by reactive oxygen species causes cell death in differentiated PC12 cells. Journal of neurochemistry 20010801
Regulation of MDR1 promoter activity in human breast carcinoma cells by protein kinase C isozymes alpha and theta. European journal of biochemistry 20010801
Protein kinase epsilon dampens the secretory response of model intestinal epithelia during ischemia. Surgery 20010801
Rottlerin-independent attenuation of pervanadate-induced tyrosine phosphorylation events by protein kinase C-delta in hemopoietic cells. Laboratory investigation; a journal of technical methods and pathology 20010801
Anticancer drug-mediated induction of multidrug resistance-associated genes and protein kinase C isozymes in the T-lymphoblastoid cell line CCRF-CEM and in blasts from patients with acute lymphoblastic leukemias. Japanese journal of cancer research : Gann 20010801
Induction of peroxiredoxin gene expression by oxygen in lungs of newborn primates. American journal of respiratory cell and molecular biology 20010801
Docosahexaenoic acid modulates phorbol ester-induced activation of extracellular signal-regulated kinases 1 and 2 in NIH/3T3 cells. Lipids 20010801
Retinoic acid causes MEK-dependent RAF phosphorylation through RARalpha plus RXR activation in HL-60 cells. Differentiation; research in biological diversity 20010801
Protein kinase C epsilon suppresses Abeta production and promotes activation of alpha-secretase. Biochemical and biophysical research communications 20010727
Inhibition of acetylcholine-activated K(+) current by chelerythrine and bisindolylmaleimide I in atrial myocytes from mice. European journal of pharmacology 20010727
Evidence that protein kinase C (PKC) participates in the meiosis I to meiosis II transition in mouse oocytes. Developmental biology 20010715
In vivo mechanisms of vascular endothelial growth factor-mediated increased hydraulic conductivity of Rana capillaries. The Journal of physiology 20010715
The antitumor somatostatin analogue TT-232 induces cell cycle arrest through PKCdelta and c-Src. Biochemical and biophysical research communications 20010713
The effect of aliphatic, naphthenic, and aromatic hydrocarbons on production of reactive oxygen species and reactive nitrogen species in rat brain synaptosome fraction: the involvement of calcium, nitric oxide synthase, mitochondria, and phospholipase A. Biochemical pharmacology 20010701
Calyculin-A induces focal adhesion assembly and tyrosine phosphorylation of p125(Fak), p130(Cas), and paxillin in Swiss 3T3 cells. Journal of cellular physiology 20010701
Post-ischemic PKC inhibition impairs myocardial calcium handling and increases contractile protein calcium sensitivity. Cardiovascular research 20010701
Role of zinc in pulmonary endothelial cell response to oxidative stress. American journal of physiology. Lung cellular and molecular physiology 20010701
Heat shock prevents simulated ischemia-induced apoptosis in renal tubular cells via a PKC-dependent mechanism. American journal of physiology. Regulatory, integrative and comparative physiology 20010701
Intracellular signals triggered during association of Mycobacterium leprae and Mycobacterium bovis BCG with human monocytes. Microbial pathogenesis 20010701
Antigonadotropic action of adenosine triphosphate in human granulosa-luteal cells: involvement of protein kinase Calpha. The Journal of clinical endocrinology and metabolism 20010701
Medium-chain fatty acids stimulate interleukin-8 production in Caco-2 cells with different mechanisms from long-chain fatty acids. Journal of gastroenterology and hepatology 20010701
Stimulation of interleukin-6 promoter by parathyroid hormone, tumor necrosis factor alpha, and interleukin-1beta in UMR-106 osteoblastic cells is inhibited by protein kinase C antagonists. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20010701
Signal transduction pathways in directed migration of human monocytes induced by human growth hormone in vitro. International immunopharmacology 20010701
Serotonin activation of the ERK pathway in Hermissenda: contribution of calcium-dependent protein kinase C. Journal of neurochemistry 20010701
Glutamate induces focal adhesion kinase tyrosine phosphorylation and actin rearrangement in heterologous mGluR1-expressing CHO cells via calcium/calmodulin signaling. Journal of neurochemistry 20010701
Phorbol ester treatment increases paracellular permeability across IEC-18 gastrointestinal epithelium in vitro. Digestive diseases and sciences 20010701
DNA binding of TEA/ATTS domain factors is regulated by protein kinase C phosphorylation in human choriocarcinoma cells. The Journal of biological chemistry 20010629
Albumin in the mg/l-range activates NF-kappaB in renal proximal tubule-derived cell lines via tyrosine kinases and protein kinase C. European journal of medical research 20010628
Phosphorylation of RGS9-1 by an endogenous protein kinase in rod outer segments. The Journal of biological chemistry 20010622
Protein kinase C-mediated down-regulation of MDR3 mRNA expression in Chang liver cells. Biochemical pharmacology 20010601
Calcium-sensing receptor activation induces intracellular calcium oscillations. American journal of physiology. Cell physiology 20010601
Possible involvement of Rho kinase in Ca2+ sensitization and mobilization by MCh in tracheal smooth muscle. American journal of physiology. Lung cellular and molecular physiology 20010601
TSH-induced differentiated functions correlate with enhancement of phosphotyrosine phosphatase activity in thyroid cells. Effect of phorbol 12-myristate 13-acetate. The Journal of endocrinology 20010601
Up-regulation of TNF-alpha convertase (TACE/ADAM17) after oxygen-glucose deprivation in rat forebrain slices. Neuropharmacology 20010601
Activation of store-operated Ca2+ entry in RBL cells without the contribution of protein kinases. Naunyn-Schmiedeberg's archives of pharmacology 20010601
Propofol increases myofilament Ca2+ sensitivity and intracellular pH via activation of Na+-H+ exchange in rat ventricular myocytes. Anesthesiology 20010601
Hypoxia alters the sensitivity of the L-type Ca(2+) channel to alpha-adrenergic receptor stimulation in the presence of beta-adrenergic receptor stimulation. Circulation research 20010525
Capsaicin potentiates 1,25-dihydoxyvitamin D3- and all-trans retinoic acid-induced differentiation of human promyelocytic leukemia HL-60 cells. European journal of pharmacology 20010525
Down-regulation of intrinsic P-glycoprotein expression in multicellular prostate tumor spheroids by reactive oxygen species. The Journal of biological chemistry 20010518
Receptor-mediated inhibition of G protein-coupled inwardly rectifying potassium channels involves G(alpha)q family subunits, phospholipase C, and a readily diffusible messenger. The Journal of biological chemistry 20010518
Novel gp91(phox) homologues in vascular smooth muscle cells : nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways. Circulation research 20010511
Phosphorylation of murine homeodomain protein Dlx3 by protein kinase C. FEBS letters 20010504
Protein kinase C-mediated desensitization of the neurokinin 1 receptor. American journal of physiology. Cell physiology 20010501
Pertussis toxin directly activates endothelial cell p42/p44 MAP kinases via a novel signaling pathway. American journal of physiology. Cell physiology 20010501
Differential effects of growth hormone and insulin-like growth factor I on human endothelial cell migration. American journal of physiology. Cell physiology 20010501
Key role of PKC and Ca2+ in EGF protection of microtubules and intestinal barrier against oxidants. American journal of physiology. Gastrointestinal and liver physiology 20010501
Importance of PKC and PI3Ks in ethanol-induced contraction of cerebral arterial smooth muscle. American journal of physiology. Heart and circulatory physiology 20010501
Induction of embryonic dysmorphogenesis by high glucose concentration, disturbed inositol metabolism, and inhibited protein kinase C activity. Teratology 20010501
Leukotriene D(4) affects localisation of vinculin in intestinal epithelial cells via distinct tyrosine kinase and protein kinase C controlled events. Journal of cell science 20010501
Protein kinase C regulation of dopamine transporter initiated by nicotinic receptor activation in slices of rat prefrontal cortex. Journal of neurochemistry 20010501
Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver. Hepatology (Baltimore, Md.) 20010501
Extracellular ATP stimulates an inhibitory pathway towards growth factor-induced cRaf-1 and MEKK activation in astrocyte cultures. Journal of neurochemistry 20010501
Effects of insulin-like growth factor-1 on retinal endothelial cell glucose transport and proliferation. Journal of neurochemistry 20010501
Analysis of the signal pathways involved in the regulation of fatty acid synthase gene expression by insulin and somatotropin. Journal of animal science 20010501
Saturated non-esterified fatty acids stimulate de novo diacylglycerol synthesis and protein kinase c activity in cultured aortic smooth muscle cells. Diabetologia 20010501
Hypoxic enhancement of evoked noradrenaline release from the human neuroblastoma SH-SY5Y. Brain research. Molecular brain research 20010418
Altered expression of glutamate transporters under hypoxic conditions in vitro. Journal of neuroscience research 20010415
Targeted inhibition of calcineurin signaling blocks calcium-dependent reactivation of Kaposi sarcoma-associated herpesvirus. Blood 20010415
Phosphorylation of the N-ethylmaleimide-sensitive factor is associated with depolarization-dependent neurotransmitter release from synaptosomes. The Journal of biological chemistry 20010413
Ischemic preconditioning upregulates vascular endothelial growth factor mRNA expression and neovascularization via nuclear translocation of protein kinase C epsilon in the rat ischemic myocardium. Circulation research 20010413
Use of A-192621 to provide evidence for involvement of endothelin ET(B)-receptors in endothelin-1-mediated cardiomyocyte hypertrophy. European journal of pharmacology 20010413
PLD pathway involved in carbachol-induced Cl- secretion: possible role of TNF-alpha. American journal of physiology. Cell physiology 20010401
Human uterine myometrial smooth muscle cell proliferation and vascular endothelial growth-factor production in response to platelet-derived growth factor. The Journal of endocrinology 20010401
Synergistic induction of apoptosis in human leukemia cells (U937) exposed to bryostatin 1 and the proteasome inhibitor lactacystin involves dysregulation of the PKC/MAPK cascade. Blood 20010401
Mechanism of action of the calcium-sensing receptor in human antral gastrin cells. Gastroenterology 20010401
Down-regulation of Na-K-Cl cotransport by protein kinase C is mediated by protein phosphatase 1 in pigmented ciliary epithelial cells. Experimental eye research 20010401
Modulation of rat erg1, erg2, erg3 and HERG K+ currents by thyrotropin-releasing hormone in anterior pituitary cells via the native signal cascade. The Journal of physiology 20010401
Interaction of CD163 with the regulatory subunit of casein kinase II (CKII) and dependence of CD163 signaling on CKII and protein kinase C. European journal of immunology 20010401
The role of protein kinase C in the regulation of serotonin-2A receptor expression. Journal of neurochemistry 20010401
Levosimendan increases diastolic coronary flow in isolated guinea-pig heart by opening ATP-sensitive potassium channels. Journal of cardiovascular pharmacology 20010401
Mechanisms of thrombin-induced MAPK activation associated with cell proliferation in human cultured tracheal smooth muscle cells. Cellular signalling 20010401
Signal transduction pathways for activation of extracellular signal-regulated kinase by arachidonic acid in rat neutrophils. Journal of leukocyte biology 20010401
Phorbol ester differentially regulates oxytocin receptor binding activity in hypothalamic cultured neurons and astrocytes. Peptides 20010401
Protein kinase C alpha modulates the Ca2+ influx phase of the Ca2+ response to 1alpha,25-dihydroxy-vitamin-D3 in skeletal muscle cells. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20010401
Chemorepellent signaling through the PACAP/lysozyme receptor is mediated through cAMP and PKC in Tetrahymena thermophila. Journal of comparative physiology. A, Sensory, neural, and behavioral physiology 20010401
Herpesvirus quiescence in neuronal cells IV: virus activation induced by pituitary adenylate cyclase-activating polypeptide (PACAP) involves the protein kinase A pathway. Journal of neurovirology 20010401
Cyclization strategies for the synthesis of macrocyclic bisindolylmaleimides. The Journal of organic chemistry 20010323
Thrombin activates p38 mitogen-activated protein kinase in vascular smooth muscle cells. Life sciences 20010316
Stimulation of extracellular signal-regulated kinases and proliferation in rat osteoblastic cells by parathyroid hormone is protein kinase C-dependent. The Journal of biological chemistry 20010309
Glycated serum albumin-induced vascular smooth muscle cell proliferation through activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by protein kinase C. Biochemical and biophysical research communications 20010309
Upregulation of p21(WAF1/CIP1) leads to morphologic changes and esterase activity in TPA-mediated differentiation of human prostate cancer cell line TSU-Pr1. Oncogene 20010308
G-protein-coupled receptor kinase 3- and protein kinase C-mediated desensitization of the PACAP receptor type 1 in human Y-79 retinoblastoma cells. Neuropharmacology 20010301
Modulation of cyclin D1 and its signaling components by the phorbol ester TPA and the tyrosine phosphatase inhibitor vanadate. Journal of cellular physiology 20010301
Sequential activation of heterotrimeric and monomeric G proteins mediates PLD activity in smooth muscle. American journal of physiology. Gastrointestinal and liver physiology 20010301
Interleukin-1beta enhances retinoic acid-mediated expression of bone-type alkaline phosphatase in rat IEC-6 cells. American journal of physiology. Gastrointestinal and liver physiology 20010301
Essential activation of PKC-delta in opioid-initiated cardioprotection. American journal of physiology. Heart and circulatory physiology 20010301
Angiotensin AT(1) receptor phosphorylation and desensitization in a hepatic cell line. Roles of protein kinase c and phosphoinositide 3-kinase. Molecular pharmacology 20010301
Sp1-p53 heterocomplex mediates activation of HTLV-I long terminal repeat by 12-O-tetradecanoylphorbol-13-acetate that is antagonized by protein kinase C. Virology 20010301
Ceramide-induced cell death in the prostate cancer cell line LNCaP has both necrotic and apoptotic features. The Prostate 20010301
Enhancement of lysophosphatidic acid-induced ERK phosphorylation by phospholipase D1 via the formation of phosphatidic acid. Biochemical and biophysical research communications 20010301
Vascular endothelial growth factor and the in vivo increase in plasma extravasation in the hamster cheek pouch. British journal of pharmacology 20010301
Induction of the monocytic differentiation of myeloid leukaemia cells by cotylenin A, a plant growth regulator. British journal of haematology 20010301
Protein kinase C-dependent and -independent inhibition of Ca(2+) influx by phorbol ester in rat pancreatic beta-cells. Cellular signalling 20010301
ATP stimulated cyclic AMP formation in bovine chromaffin cells is enhanced by neuropeptide Y. Peptides 20010301
Progesterone effect mediated by the voltage-dependent calcium channel and protein kinase C on noncapacitated cryopreserved bovine spermatozoa. Andrologia 20010301
The stimulation of MAP kinase by 1,25(OH)(2)-vitamin D(3) in skeletal muscle cells is mediated by protein kinase C and calcium. Molecular and cellular endocrinology 20010227
Potent direct inhibition of mammalian phospholipase D isoenzymes by calphostin-c. Biochemistry 20010227
Inhibition of depolarisation-evoked [(3)H]noradrenaline release from SH-SYFY human neuroblastoma cells by muscarinic (M1) receptors is not mediated by changes in [Ca(2+)]. Brain research. Molecular brain research 20010219
Use of protein kinase C inhibitors results in rapid [Mg(2+)](i) mobilization in primary cultured rat aortic smooth muscle cells: are certain kinase C isoforms natural homeostatic regulators of cystolic free Mg(2+). European journal of pharmacology 20010216
Monocytes are differentially activated through HLA-DR, -DQ, and -DP molecules via mitogen-activated protein kinases. Journal of immunology (Baltimore, Md. : 1950) 20010215
Adenosine triphosphate-evoked cytosolic calcium oscillations in human granulosa-luteal cells: role of protein kinase C. The Journal of clinical endocrinology and metabolism 20010201
Upregulation of angiotensin-converting enzyme by vascular endothelial growth factor. American journal of physiology. Heart and circulatory physiology 20010201
Involvement of protein kinase C in the presynaptic nicotinic modulation of [(3)H]-dopamine release from rat striatal synaptosomes. British journal of pharmacology 20010201
Regulation of phosphate uptake in primary cultured rabbit renal proximal tubule cells by glucocorticoids: evidence for nongenomic as well as genomic mechanisms. Endocrinology 20010201
Differential actions of PKA and PKC in the regulation of glutamate release by group III mGluRs in the entorhinal cortex. Journal of neurophysiology 20010201
Ethanol activates NFkappaB DNA binding and p56lck protein tyrosine kinase in human osteoblast-like cells. Bone 20010201
Purine and pyrimidine nucleotide-sensitive phospholipase A(2) in ampulla from frog semicircular canal. American journal of physiology. Regulatory, integrative and comparative physiology 20010201
Signaling events mediating the additive effects of oleic acid and angiotensin II on vascular smooth muscle cell migration. Hypertension (Dallas, Tex. : 1979) 20010201
Oxidized-LDL enhances coronary vasoconstriction by increasing the activity of protein kinase C isoforms alpha and epsilon. Hypertension (Dallas, Tex. : 1979) 20010201
Interactions between 2-fluoroadenine 9-beta-D-arabinofuranoside and the kinase inhibitor UCN-01 in human leukemia and lymphoma cells. Clinical cancer research : an official journal of the American Association for Cancer Research 20010201
Vascular endothelial growth factor enhances the expression of urokinase receptor in human endothelial cells via protein kinase C activation. Thrombosis and haemostasis 20010201
Differential sensitivity of breast cancer cells to tumor necrosis factor-alpha: involvement of protein kinase C. Biochemical and biophysical research communications 20010126
Angiotensin AT(1) and AT(2) receptors differentially regulate angiopoietin-2 and vascular endothelial growth factor expression and angiogenesis by modulating heparin binding-epidermal growth factor (EGF)-mediated EGF receptor transactivation. Circulation research 20010119
p53-independent elevation of p21 expression by PMA results from PKC-mediated mRNA stabilization. Biochemical and biophysical research communications 20010112
Selective secretion of protein kinase C isozymes by thrombin-stimulated human platelets. Biochemical and biophysical research communications 20010112
A potential role for protein kinase C-epsilon in regulating megakaryocytic lineage commitment. The Journal of biological chemistry 20010105
Modulation of inducible nitric oxide synthase expression in rat intestinal cells by colon tumor promoters. International journal of oncology 20010101
A proposed mechanism for the potentiation of cAMP-mediated acid secretion by carbachol. American journal of physiology. Cell physiology 20010101
Extracellular signal-regulated kinase and the small GTP-binding protein p21Rac1 are involved in the regulation of gene transcription by angiotensin II. Experimental nephrology 20010101
Phorbol ester-induced inhibition of potassium currents in rat sensory neurons requires voltage-dependent entry of calcium. Journal of neurophysiology 20010101
High glucose stimulates Ca2+ uptake via cAMP and PLC/PKC pathways in primary cultured renal proximal tubule cells. Kidney & blood pressure research 20010101
Modulation of noradrenaline-induced microvascular constriction by protein kinase inhibitors. Naunyn-Schmiedeberg's archives of pharmacology 20010101
Modulation of H2 histamine receptor-mediated cAMP generation and granulocytic differentiation by extracellular nucleotides via activation of protein kinase C. Journal of leukocyte biology 20010101
Role of mitogen-activated protein kinase in prostaglandin f(2alpha) action in human granulosa-luteal cells. The Journal of clinical endocrinology and metabolism 20010101
Protein tyrosine kinase-dependent regulation of adenylate cyclase and phosphatidylinositol 3-kinase activates the expression of glial fibrillary acidic protein upon induction of differentiation in rat c6 glioma. Cell biology international 20010101
Bradykinin induces protein kinase C-dependent activation of phospholipase D in A-431 cells. IUBMB life 20010101
High glucose levels alter angiotensin II-induced Ca(2+) uptake via PKC and cAMP pathways in renal proximal tubular cells. Kidney & blood pressure research 20010101
High glucose levels enhance TGF-beta1-thrombospondin-1 pathway in cultured human mesangial cells via mechanisms dependent on glucose-induced PKC activation. Journal of diabetes and its complications 20010101
Characterisation of the rat SK4/IK1 K(+) channel. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20010101
Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27. Cell stress & chaperones 20010101
Phorbol ester impairs electrical excitation of rat pancreatic beta-cells through PKC-independent activation of KATP channels. BMC pharmacology 20010101
Effect of wortmannin and phorbol ester on Paramecium fluid-phase uptake in the presence of transferrin. European journal of histochemistry : EJH 20010101
Protein kinase Calpha mediates the effect of antiarrhythmic peptide on gap junction conductance. Cell communication & adhesion 20010101
Neutrophil apoptosis is delayed by trauma patients' plasma via a mechanism involving proinflammatory phospholipids and protein kinase C. Surgical infections 20010101
Purinergic and adrenergic agonists synergize in stimulating vasopressin and oxytocin release. The Journal of neuroscience : the official journal of the Society for Neuroscience 20001201
Protein kinase C activation modulates pro- and anti-apoptotic signaling pathways. European journal of cell biology 20001101
Specificity and mechanism of action of some commonly used protein kinase inhibitors. The Biochemical journal 20001001
5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases. Proceedings of the National Academy of Sciences of the United States of America 20000509
Trp-Lys-Tyr-Met-Val-D-Met is a chemoattractant for human phagocytic cells. Journal of leukocyte biology 19991201
Thioredoxin reductase is the major selenoprotein expressed in human umbilical-vein endothelial cells and is regulated by protein kinase C. The Biochemical journal 19990815
Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells. The Journal of biological chemistry 19990226
Trp-Lys-Tyr-Met-Val-D-Met stimulates superoxide generation and killing of Staphylococcus aureus via phospholipase D activation in human monocytes. Journal of leukocyte biology 19990201
Protein kinase Cdelta-dependent induction of manganese superoxide dismutase gene expression by microtubule-active anticancer drugs. The Journal of biological chemistry 19981218
Calcium-mediated second messengers modulate the expression of behavioral sensitization to cocaine. The Journal of pharmacology and experimental therapeutics 19980901
Tyrosine phosphorylation and proteolysis. Pervanadate-induced, metalloprotease-dependent cleavage of the ErbB-4 receptor and amphiregulin. The Journal of biological chemistry 19980807
Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure. Bioorganic & medicinal chemistry letters 19980505
Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976. The Journal of biological chemistry 19930505
Anti-inflammatory properties of the protein kinase C inhibitor, 3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H- pyrrole-2,5-dione monohydrochloride (GF109203X) in the PMA-mouse ear edema model. Agents and actions 19930101
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. The Journal of biological chemistry 19910825
Dehydroepiandrosterone sulfate directly activates protein kinase C-beta to increase human neutrophil superoxide generation. Molecular endocrinology (Baltimore, Md.)

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