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132956-87-7 | L-Cysteinamide, L-arginyl-L-cysteinyl-3-cyclohexyl-L-alanylglycylglycyl-L-arginyl-L-isoleucyl-L-α-aspartyl-L-arginyl-L-isoleucyl-(3R)-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-arginyl-, cyclic (2→13)-disulfide
CAS No: 132956-87-7 Catalog No: AG0011FW MDL No:
Product Description
Catalog Number:
AG0011FW
Chemical Name:
L-Cysteinamide, L-arginyl-L-cysteinyl-3-cyclohexyl-L-alanylglycylglycyl-L-arginyl-L-isoleucyl-L-α-aspartyl-L-arginyl-L-isoleucyl-(3R)-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-arginyl-, cyclic (2→13)-disulfide
CAS Number:
132956-87-7
IUPAC Name:
2-[(3S,6S,9S,12S,15R,24S,27R,31R,32R,38R)-27-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3,12-bis[(2S)-butan-2-yl]-32-carbamoyl-24-(cyclohexylmethyl)-6,15,31-tris[3-(diaminomethylideneamino)propyl]-2,5,8,11,14,17,20,23,26,34,37-undecaoxo-29,30-dithia-1,4,7,10,13,16,19,22,25,33,36-undecazatricyclo[36.8.0.040,45]hexatetraconta-40,42,44-trien-9-yl]acetic acid
InChI:
InChI=1S/C69H116N26O15S2/c1-5-36(3)53-64(109)90-45(30-52(99)100)61(106)88-43(22-14-26-82-68(76)77)60(105)94-54(37(4)6-2)65(110)95-34-40-19-11-10-18-39(40)29-47(95)63(108)86-33-51(98)92-55(56(71)101)48(23-15-27-83-69(78)79)112-111-35-46(91-57(102)41(70)20-12-24-80-66(72)73)62(107)89-44(28-38-16-8-7-9-17-38)58(103)85-31-49(96)84-32-50(97)87-42(59(104)93-53)21-13-25-81-67(74)75/h10-11,18-19,36-38,41-48,53-55H,5-9,12-17,20-35,70H2,1-4H3,(H2,71,101)(H,84,96)(H,85,103)(H,86,108)(H,87,97)(H,88,106)(H,89,107)(H,90,109)(H,91,102)(H,92,98)(H,93,104)(H,94,105)(H,99,100)(H4,72,73,80)(H4,74,75,81)(H4,76,77,82)(H4,78,79,83)/t36-,37-,41-,42+,43-,44-,45-,46-,47+,48+,53-,54-,55-/m0/s1
InChI Key:
TZQXLCWSYQJGKV-YGLLJKSHSA-N
Properties
Complexity:
3310
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
13
Defined Bond Stereocenter Count:
0
Exact Mass:
1612.855g/mol
Formal Charge:
0
Heavy Atom Count:
112
Hydrogen Bond Acceptor Count:
22
Hydrogen Bond Donor Count:
22
Isotope Atom Count:
0
Molecular Weight:
1613.974g/mol
Monoisotopic Mass:
1612.855g/mol
Rotatable Bond Count:
27
Topological Polar Surface Area:
755A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-6.7
Literature
| Title | Journal |
|---|---|
| Spinal Functions of B-Type Natriuretic Peptide, Gastrin-Releasing Peptide, and Their Cognate Receptors for Regulating Itch in Mice. | The Journal of pharmacology and experimental therapeutics 20160301 |
| Natriuretic peptides regulate heart rate and sinoatrial node function by activating multiple natriuretic peptide receptors. | Journal of molecular and cellular cardiology 20121101 |
| The natriuretic peptides BNP and CNP increase heart rate and electrical conduction by stimulating ionic currents in the sinoatrial node and atrial myocardium following activation of guanylyl cyclase-linked natriuretic peptide receptors. | Journal of molecular and cellular cardiology 20120501 |
| Role of B-type natriuretic peptide in epoxyeicosatrienoic acid-mediated improved post-ischaemic recovery of heart contractile function. | Cardiovascular research 20090715 |
| Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure. | Arteriosclerosis, thrombosis, and vascular biology 20040501 |
| Functional and pharmacological characterization of the natriuretic peptide-dependent lipolytic pathway in human fat cells. | The Journal of pharmacology and experimental therapeutics 20040301 |
| Guanylyl cyclase receptors mediate cardiopulmonary vagal reflex actions of ANP. | Hypertension (Dallas, Tex. : 1979) 20030201 |
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