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132810-10-7

132810-10-7 | Cycloocta[b]pyridine, 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydro-

CAS No: 132810-10-7 Catalog No: AG00117R MDL No:MFCD00893838

Product Description

Catalog Number:
AG00117R
Chemical Name:
Cycloocta[b]pyridine, 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydro-
CAS Number:
132810-10-7
Molecular Formula:
C23H30FN3
Molecular Weight:
367.5028
MDL Number:
MFCD00893838
IUPAC Name:
2-(4-ethylpiperazin-1-yl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
InChI:
InChI=1S/C23H30FN3/c1-2-26-13-15-27(16-14-26)23-17-21(18-9-11-19(24)12-10-18)20-7-5-3-4-6-8-22(20)25-23/h9-12,17H,2-8,13-16H2,1H3
InChI Key:
XVGOZDAJGBALKS-UHFFFAOYSA-N
SMILES:
CCN1CCN(CC1)c1nc2CCCCCCc2c(c1)c1ccc(cc1)F
UNII:
AQ316B4F8C

Properties

Complexity:
443  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
367.242g/mol
Formal Charge:
0
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
367.512g/mol
Monoisotopic Mass:
367.242g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
19.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
5.5  

Literature

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Quetiapine-induced insulin resistance after switching from blonanserin despite a loss in both bodyweight and waist circumference. Psychiatry and clinical neurosciences 20121001
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The relationship between the plasma concentration of blonanserin, and its plasma anti-serotonin 5-HT(2A) activity/anti-dopamine D₂ activity ratio and drug-induced extrapyramidal symptoms. Psychiatry and clinical neurosciences 20120301
Effect of blonanserin on cognitive function in antipsychotic-naïve first-episode schizophrenia. Human psychopharmacology 20120101
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Five Alzheimer's disease cases with refractory behavioural psychological symptoms of dementia treated with blonanserin. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society 20101201
Adjunctive treatment with low-dosage aripiprazole for blonanserin-induced hyperprolactinemia in a female patient with schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry 20101001
Case of delirium complicated with pneumonia that improved with blonanserin administration. Psychiatry and clinical neurosciences 20101001
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Atypical antipsychotic properties of blonanserin, a novel dopamine D2 and 5-HT2A antagonist. Pharmacology, biochemistry, and behavior 20100801
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Efficacy of blonanserin in combination therapy for treatment-resistant depression. Psychiatry and clinical neurosciences 20090801
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Blonanserin. AD 5423. Drugs in R&D 20020101
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