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Home > Indoles and Oxindole > 1323403-33-3
1323403-33-3 | (S)-3-[4-(4-Morpholin-4-yl-methyl-benzyloxy)-1-oxo-1,3-dihydro-isoindol-2-yl]-piperidine-2,6-dione
CAS No: 1323403-33-3 Catalog No: AG01EB1L MDL No:MFCD31382133
Product Description
Catalog Number:
AG01EB1L
Chemical Name:
(S)-3-[4-(4-Morpholin-4-yl-methyl-benzyloxy)-1-oxo-1,3-dihydro-isoindol-2-yl]-piperidine-2,6-dione
CAS Number:
1323403-33-3
Molecular Formula:
C25H27N3O5
Molecular Weight:
449.4990
MDL Number:
MFCD31382133
IUPAC Name:
(3S)-3-[7-[[4-(morpholin-4-ylmethyl)phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione
InChI:
InChI=1S/C25H27N3O5/c29-23-9-8-21(24(30)26-23)28-15-20-19(25(28)31)2-1-3-22(20)33-16-18-6-4-17(5-7-18)14-27-10-12-32-13-11-27/h1-7,21H,8-16H2,(H,26,29,30)/t21-/m0/s1
InChI Key:
IXZOHGPZAQLIBH-NRFANRHFSA-N
SMILES:
O=C1CC[C@@H](C(=O)N1)N1Cc2c(C1=O)cccc2OCc1ccc(cc1)CN1CCOCC1
UNII:
8V66F27X44
Properties
Complexity:
732
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
1
Defined Bond Stereocenter Count:
0
Exact Mass:
449.195g/mol
Formal Charge:
0
Heavy Atom Count:
33
Hydrogen Bond Acceptor Count:
6
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
449.507g/mol
Monoisotopic Mass:
449.195g/mol
Rotatable Bond Count:
6
Topological Polar Surface Area:
88.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.1
Literature
| Title | Journal |
|---|---|
| A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos. | Journal of medicinal chemistry 20180125 |
| Rate of CRL4(CRBN) substrate Ikaros and Aiolos degradation underlies differential activity of lenalidomide and pomalidomide in multiple myeloma cells by regulation of c-Myc and IRF4. | Blood cancer journal 20151001 |
| Association between polymorphisms of the IKZF3 gene and systemic lupus erythematosus in a Chinese Han population. | PloS one 20140101 |
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