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CAS No: 132203-70-4 Catalog No: AG0010DR MDL No:MFCD00865853
Title | Journal |
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Differential modulation of FXR activity by chlorophacinone and ivermectin analogs. | Toxicology and applied pharmacology 20161215 |
Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. | Scientific reports 20140101 |
Investigation of inclusion complex of cilnidipine with hydroxypropyl-β-cyclodextrin. | Carbohydrate polymers 20121106 |
Renoprotective and antioxidant effects of cilnidipine in hypertensive patients. | Hypertension research : official journal of the Japanese Society of Hypertension 20121101 |
The efficacy and safety of cilnidipine on mild to moderate essential hypertension: a systematic review and meta-analysis of randomized controlled trials in Chinese patients. | Cardiovascular & hematological disorders drug targets 20120901 |
Comparison of the effects of cilnidipine and amlodipine on cardiac remodeling and diastolic dysfunction in Dahl salt-sensitive rats. | Journal of hypertension 20120901 |
N-type calcium channel inhibition with cilnidipine elicits glomerular podocyte protection independent of sympathetic nerve inhibition. | Journal of pharmacological sciences 20120818 |
L/N-type calcium channel blocker suppresses reflex aldosterone production induced by antihypertensive action. | Heart and vessels 20120701 |
Antialbuminuric advantage of cilnidipine compared with L-type calcium channel blockers in type 2 diabetic patients with normoalbuminuria and microalbuminuria. | Diabetes research and clinical practice 20120701 |
Cilnidipine, an L/N-type calcium channel blocker prevents acquisition and expression of ethanol-induced locomotor sensitization in mice. | Neuroscience letters 20120411 |
Anti-stress effects of cilnidipine and nimodipine in immobilization subjected mice. | Physiology & behavior 20120320 |
Cilnidipine, but not amlodipine, ameliorates osteoporosis in ovariectomized hypertensive rats through inhibition of the N-type calcium channel. | Hypertension research : official journal of the Japanese Society of Hypertension 20120101 |
Switching to an L/N-type calcium channel blocker shows renoprotective effects in patients with chronic kidney disease: the Kyoto Cilnidipine Study. | The Journal of international medical research 20120101 |
Asymmetric synthesis and biological evaluations of (+)- and (-)-6-dimethoxymethyl-1,4-dihydropyridine-3-carboxylic acid derivatives blocking N-type calcium channels. | Bioorganic & medicinal chemistry letters 20110601 |
Dual actions of cilnidipine in human internal thoracic artery: inhibition of calcium channels and enhancement of endothelial nitric oxide synthase. | The Journal of thoracic and cardiovascular surgery 20110401 |
L/N-type calcium channel blocker cilnidipine ameliorates proteinuria and inhibits the renal renin-angiotensin-aldosterone system in deoxycorticosterone acetate-salt hypertensive rats. | Hypertension research : official journal of the Japanese Society of Hypertension 20110401 |
Beneficial effects of L- and N-type calcium channel blocker on glucose and lipid metabolism and renal function in patients with hypertension and type II diabetes mellitus. | Cardiovascular therapeutics 20110201 |
Effects of an N-type calcium antagonist on angiotensin II-renin feedback. | American journal of nephrology 20110101 |
Effects of the L/N-type calcium channel antagonist cilnidipine on morning blood pressure control and peripheral edema formation. | Journal of the American Society of Hypertension : JASH 20110101 |
Design and rationale of the study of assessment for kidney function by urinary microalbumin in randomized (SAKURA) trial. | Clinical and experimental hypertension (New York, N.Y. : 1993) 20110101 |
Anti-leishmanial and anti-trypanosomal activities of 1,4-dihydropyridines: In vitro evaluation and structure-activity relationship study. | Bioorganic & medicinal chemistry 20101115 |
The N-type and L-type calcium channel blocker cilnidipine suppresses renal injury in Dahl rats fed a high-salt diet. | Heart and vessels 20101101 |
A new-generation N/L-type calcium channel blocker leads to less activation of the renin-angiotensin system compared with conventional L type calcium channel blocker. | Journal of hypertension 20101001 |
Comparison between the antiproteinuric effects of the calcium channel blockers benidipine and cilnidipine in combination with angiotensin receptor blockers in hypertensive patients with chronic kidney disease. | Expert opinion on investigational drugs 20100901 |
Cilnidipine suppresses podocyte injury and proteinuria in metabolic syndrome rats: possible involvement of N-type calcium channel in podocyte. | Journal of hypertension 20100501 |
Effect of cilnidipine vs losartan on cerebral blood flow in hypertensive patients with a history of ischemic stroke: a randomized controlled trial. | Acta neurologica Scandinavica 20100101 |
[Calcium antagonists: current and future applications based on new evidence. Calcium channel blockers and autonomic nervous system]. | Clinical calcium 20100101 |
[Calcium antagonists: current and future applications based on new evidence. Neuroprotective effect of calcium antagonists]. | Clinical calcium 20100101 |
The L/N-type calcium channel blocker, Cilnidipine, reduces heart rate and albuminuria in patients with type 2 diabetes. | The Journal of international medical research 20100101 |
Effect of cilnidipine on normal to marginally elevated urine albumin-creatinine ratio in asymptomatic non-diabetic hypertensive patients: an exponential decay curve analysis. | Clinical drug investigation 20100101 |
Antiproteinuric effect of cilnidipine in hypertensive Japanese treated with renin-angiotensin-system inhibitors - a multicenter, open, randomized trial using 24-hour urine collection. | Clinical and experimental hypertension (New York, N.Y. : 1993) 20100101 |
Oral administration of cilnidipine to patients with hypertensive intracerebral hemorrhage in the acute stage: significance and role of an N-type calcium channel blocker. | Irish journal of medical science 20091201 |
Long-term blockade of L/N-type Ca(2+) channels by cilnidipine ameliorates repolarization abnormality of the canine hypertrophied heart. | British journal of pharmacology 20091101 |
Cilnidipine mediates a neuroprotective effect by scavenging free radicals and activating the phosphatidylinositol 3-kinase pathway. | Journal of neurochemistry 20091001 |
Cardioprotective effect of an L/N-type calcium channel blocker in patients with hypertensive heart disease. | Journal of cardiology 20091001 |
Suppression of formalin-induced nociception by cilnidipine, a voltage-dependent calcium channel blocker. | Biological & pharmaceutical bulletin 20091001 |
Effects of a dual L/N-type calcium channel blocker cilnidipine on blood pressure, pulse rate, and autonomic functions in patients with mild to moderate hypertension. | Clinical and experimental hypertension (New York, N.Y. : 1993) 20091001 |
Efficacy of an L- and N-type calcium channel blocker in hypertensive patients with neurovascular compression of the rostral ventrolateral medulla. | Hypertension research : official journal of the Japanese Society of Hypertension 20090801 |
Comparison of antioxidant activity of cilnidipine and amlodipine. | Kidney international 20090701 |
Histological protection by cilnidipine, a dual L/N-type Ca(2+) channel blocker, against neurotoxicity induced by ischemia-reperfusion in rat retina. | Experimental eye research 20090501 |
Cilnidipine inhibits the sympathetic nerve activity and improves baroreflex sensitivity in patients with hypertension. | Clinical and experimental hypertension (New York, N.Y. : 1993) 20090501 |
The calcium channel blocker cilnidipine selectively suppresses hypoxia-inducible factor 1 activity in vascular cells. | European journal of pharmacology 20090315 |
Different effects of L/N-type and L-type calcium channel blockers on the renin-angiotensin-aldosterone system in SHR/Izm. | American journal of nephrology 20090101 |
Renoprotective effect of the L/N-type calcium channel antagonist cilnidipine on puromycin aminonucleoside-induced nephrosis in rats. | Arzneimittel-Forschung 20090101 |
Cilnidipine: a new generation Ca channel blocker with inhibitory action on sympathetic neurotransmitter release. | Cardiovascular therapeutics 20090101 |
Comparison of the anti-hypertensive effects of the L/N-type calcium channel antagonist cilnidipine, and the L-type calcium channel antagonist amlodipine in hypertensive patients with cerebrovascular disease. | Internal medicine (Tokyo, Japan) 20090101 |
Stress-induced blood pressure elevation in subjects with mild cognitive impairment: effects of the dual-type calcium channel blocker, cilnidipine. | Geriatrics & gerontology international 20081201 |
Vasodilatory effect of cilnidipine, an L-type and N-type calcium channel blocker, on rat kidney glomerular arterioles. | International heart journal 20081101 |
The structure-activity relationship study on 2-, 5-, and 6-position of the water soluble 1,4-dihydropyridine derivatives blocking N-type calcium channels. | Bioorganic & medicinal chemistry letters 20080901 |
Antiproteinuric effects of cilnidipine. | Kidney international 20080501 |
Development of a liquid chromatography/negative-ion electrospray tandem mass spectrometry assay for the determination of cilnidipine in human plasma and its application to a bioequivalence study. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080201 |
Antiproteinuric effect of the calcium channel blocker cilnidipine added to renin-angiotensin inhibition in hypertensive patients with chronic renal disease. | Kidney international 20071201 |
Influence of cilnidipine or nisoldipine on sympathetic activity in healthy male subjects. | Heart and vessels 20071101 |
Renal and vascular protective effects of cilnidipine in patients with essential hypertension. | Journal of hypertension 20071001 |
Determination of cilnidipine, a new calcium antagonist, in human plasma using high performance liquid chromatography with tandem mass spectrometric detection. | Analytica chimica acta 20070926 |
Bedtime administration of cilnidipine controls morning hypertension. | International heart journal 20070901 |
The effect of combination therapy with an L/N-Type Ca(2+) channel blocker, cilnidipine, and an angiotensin II receptor blocker on the blood pressure and heart rate in Japanese hypertensive patients: an observational study conducted in Japan. | Hypertension research : official journal of the Japanese Society of Hypertension 20070901 |
Assessment of the effects of L- and N-type Ca2+ channel blocking drugs using canine blood-perfused papillary muscle preparations. | The Tohoku journal of experimental medicine 20070801 |
Cardiac effects of L/N-type Ca2+ channel blocker cilnidipine in anesthetized dogs. | European journal of pharmacology 20070622 |
Cilnidipine improves left-ventricular midwall function independently of blood pressure changes in Chinese patients with hypertension. | Journal of cardiovascular pharmacology 20070101 |
Renoprotective effect of N-type Ca channel blockade in diabetic nephropathy. | Journal of diabetes and its complications 20070101 |
Effect of benidipine hydrochloride, a long-acting T-type calcium channel blocker, on blood pressure and renal function in hypertensive patients with diabetes mellitus. Analysis after switching from cilnidipine to benidipine. | Arzneimittel-Forschung 20070101 |
Effect of cilnidipine on left ventricular function in hypertensive patients as assessed by tissue Doppler Tei index. | Journal of human hypertension 20060801 |
Comparison between valsartan and valsartan plus cilnidipine in type II diabetics with normo- and microalbuminuria. | Kidney international 20060701 |
Effects of L/N-type calcium channel antagonist, cilnidipine on progressive renal injuries in Dahl salt-sensitive rats. | Biological & pharmaceutical bulletin 20060501 |
Beneficial effect of cilnidipine on morning hypertension and white-coat effect in patients with essential hypertension. | Hypertension research : official journal of the Japanese Society of Hypertension 20060501 |
Structure-activity relationship study of 1,4-dihydropyridine derivatives blocking N-type calcium channels. | Bioorganic & medicinal chemistry letters 20060215 |
Cilnidipine, a slow-acting Ca2+ channel blocker, induces relaxation in porcine coronary artery: role of endothelial nitric oxide and [Ca2+]i. | British journal of pharmacology 20060101 |
Comparison of the effects of cilnidipine and amlodipine on ambulatory blood pressure. | Hypertension research : official journal of the Japanese Society of Hypertension 20051201 |
Anti-proteinuric effect of an N-type calcium channel blocker, cilnidipine. | Clinical and experimental hypertension (New York, N.Y. : 1993) 20051101 |
Comparison of the direct negative dromotropic effect of a new calcium channel blocker, cilnidipine, with that of nicardipine. | Heart and vessels 20050501 |
Cilnidipine, an N+L-type dihydropyridine Ca channel blocker, suppresses the occurrence of ischemia/reperfusion arrhythmia in a rabbit model of myocardial infarction. | Hypertension research : official journal of the Japanese Society of Hypertension 20050401 |
The N- and L-type calcium channel blocker cilnidipine suppresses renal injury in dahl rats fed a high-sucrose diet, an experimental model of metabolic syndrome. | Nephron. Physiology 20050101 |
Prophylactic effects of an N- and L-type Ca2+ antagonist, cilnidipine, against cardiac hypertrophy and dysfunction in stroke-prone, spontaneously hypertensive rats. | Canadian journal of physiology and pharmacology 20050101 |
Different effects of L-type and L+N-type calcium channel blockers on hamster cheek pouch venules. | Journal of cardiovascular pharmacology 20041201 |
Cardiovascular effects of an L/N-type Ca2+ channel blocker cilnidipine assessed in the chronic atrioventricular conduction block dogs. | Journal of pharmacological sciences 20041001 |
Neuroprotective effects of a dual L/N-type Ca(2+) channel blocker cilnidipine in the rat focal brain ischemia model. | Biological & pharmaceutical bulletin 20040901 |
Inhibitory effect of pranidipine on N-type voltage-dependent Ca2+ channels in mice. | Neuroscience letters 20040826 |
Effect of cilnidipine on L- and T-type calcium currents in guinea pig ventricle and action potential in rabbit sinoatrial node. | Journal of pharmacological sciences 20040701 |
Effects of the long-acting calcium channel blockers, amlodipine, manidipine and cilnidipine on steroid hormones and insulin resistance in hypertensive obese patients. | Internal medicine (Tokyo, Japan) 20040701 |
[Development of desulfated chondroitin sulfate C as a novel chiral selector in capillary electrophoresis and enantioseparation of cilnidipine]. | Se pu = Chinese journal of chromatography 20040701 |
The evaluation of the N-type channel blocking properties of cilnidipine and other voltage-dependent calcium antagonists. | Fundamental & clinical pharmacology 20040601 |
Comparison between cilnidipine and amlodipine besilate with respect to proteinuria in hypertensive patients with renal diseases. | Hypertension research : official journal of the Japanese Society of Hypertension 20040601 |
[Diagnosis of and therapy for renal hypertension]. | Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20040310 |
Effect of morning and bedtime dosing with cilnidipine on blood pressure, heart rate, and sympathetic nervous activity in essential hypertensive patients. | Journal of cardiovascular pharmacology 20040101 |
Effects of calcium channel antagonists on left ventricular hypertrophy and diastolic function in patients with essential hypertension. | Clinical and experimental hypertension (New York, N.Y. : 1993) 20031101 |
[Clinical usefulness of a dual L/N-type Ca2+ channel blocker, cilnidipine, in patients with chronic heart failure: assessment with 123I-MIBG myocardial scintigraphy]. | Kaku igaku. The Japanese journal of nuclear medicine 20031101 |
Neuronal Ca2+ channel blocking action of an antihypertensive drug, cilnidipine, in IMR-32 human neuroblastoma cells. | Hypertension research : official journal of the Japanese Society of Hypertension 20030901 |
Efficacy of various antihypertensive agents as evaluated by indices of vascular stiffness in elderly hypertensive patients. | Hypertension research : official journal of the Japanese Society of Hypertension 20030801 |
Cilnidipine as an agent to lower blood pressure without sympathetic nervous activation as demonstrated by iodine-123 metaiodobenzylguanidine imaging in rat hearts. | Annals of nuclear medicine 20030601 |
Effect of cilnidipine on insulin sensitivity in patients with essential hypertension. | Hypertension research : official journal of the Japanese Society of Hypertension 20030501 |
Characterization of Ca2+ current inhibition by cilnidipine using a beta-subunit antisense oligonucleotide. | European journal of pharmacology 20030411 |
Metabolism and metabolic inhibition of cilnidipine in human liver microsomes. | Acta pharmacologica Sinica 20030301 |
Comparative effect of clinidipine and quinapril on left ventricular mass in mild essential hypertension. | Drugs under experimental and clinical research 20030101 |
Inhibitory effects of cilnidipine on peripheral and brain N-type Ca2+ channels expressed in BHK cells. | Neuropharmacology 20020601 |
Cilnidipine is a novel slow-acting blocker of vascular L-type calcium channels that does not target protein kinase C. | Journal of hypertension 20020501 |
N- and L-type calcium channel antagonist improves glomerular dynamics, reverses severe nephrosclerosis, and inhibits apoptosis and proliferation in an l-NAME/SHR model. | Journal of hypertension 20020501 |
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
Cilnidipine improves spontaneously hypertensive rat coronary hemodynamics without altering cardiovascular mass and collagen. | Journal of hypertension 20020201 |
Antisympathetic and hemodynamic property of a dual L/N-type Ca(2+) channel blocker cilnidipine in rats. | European journal of pharmacology 20020102 |
In vivo measurement of 1,4-dihydropyridine receptors in mesenteric arteries of spontaneously hypertensive rats and effect of nifedipine and cilnidipine. | Biological & pharmaceutical bulletin 20020101 |
Cilnidipine more highly attenuates cold pressor stress-induced platelet activation in hypertension than does amlodipine. | Hypertension research : official journal of the Japanese Society of Hypertension 20011101 |
Reduction of white coat effect by cilnidipine in essential hypertension. | American journal of hypertension 20011001 |
Effects of the L- and N-type calcium channel blocker cilnidipine on growth of vascular smooth muscle cells from spontaneously hypertensive rats. | Journal of cardiovascular pharmacology 20010901 |
Effects of cilnidipine on muscle fiber composition, capillary density and muscle blood flow in fructose-fed rats. | Hypertension research : official journal of the Japanese Society of Hypertension 20010901 |
Cilnidipine is as effective as benazepril for control of blood pressure and proteinuria in hypertensive patients with benign nephrosclerosis. | Hypertension research : official journal of the Japanese Society of Hypertension 20010701 |
Effects of cilnidipine on nitric oxide and endothelin-1 expression and extracellular signal-regulated kinase in hypertensive rats. | European journal of pharmacology 20010622 |
Effect of cilnidipine on left ventricular diastolic function in hypertensive patients as assessed by pulsed Doppler echocardiography and pulsed tissue Doppler imaging. | Japanese circulation journal 20010401 |
State-dependent inhibition of L-type Ca2+ channels in A7r5 cells by cilnidipine and its derivatives. | Japanese journal of pharmacology 20010301 |
Effects of a dual L/N-type Ca(2+) channel blocker cilnidipine on neurally mediated chronotropic response in anesthetized dogs. | European journal of pharmacology 20010209 |
[Effects of benidipine hydrochloride (Coniel) on blood pressure, heart rate and plasma norepinephrine concentration in spontaneously hypertensive rats]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 19990501 |
Comparison of 24-hour blood pressure, heart rate, and autonomic nerve activity in hypertensive patients treated with cilnidipine or nifedipine retard. | Journal of cardiovascular pharmacology 19980801 |
Effect of cilnidipine, a novel dihydropyridine Ca++-channel antagonist, on N-type Ca++ channel in rat dorsal root ganglion neurons. | The Journal of pharmacology and experimental therapeutics 19970301 |
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