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132033-91-1 | 3(2H)-Isoxazolone,5-(4-piperidinyl)-(9CI)
CAS No: 132033-91-1 Catalog No: AG00A7Z1 MDL No:
Product Description
Catalog Number:
AG00A7Z1
Chemical Name:
3(2H)-Isoxazolone,5-(4-piperidinyl)-(9CI)
CAS Number:
132033-91-1
IUPAC Name:
5-piperidin-4-yl-1,2-oxazol-3-one
InChI:
InChI=1S/C8H12N2O2/c11-8-5-7(12-10-8)6-1-3-9-4-2-6/h5-6,9H,1-4H2,(H,10,11)
InChI Key:
YYOYGSTYWVHCJR-UHFFFAOYSA-N
Properties
Complexity:
219
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
168.09g/mol
Formal Charge:
0
Heavy Atom Count:
12
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
168.196g/mol
Monoisotopic Mass:
168.09g/mol
Rotatable Bond Count:
1
Topological Polar Surface Area:
50.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.2
Literature
| Title | Journal |
|---|---|
| Discovery of the Fibrinolysis Inhibitor AZD6564, Acting via Interference of a Protein-Protein Interaction. | ACS medicinal chemistry letters 20140508 |
| Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as gamma-aminobutyric acid(A) receptor ligands: synthesis, pharmacology, and structure-activity relationships. | Journal of medicinal chemistry 20100422 |
| Synthesis of GABAA receptor agonists and evaluation of their alpha-subunit selectivity and orientation in the GABA binding site. | Journal of medicinal chemistry 20080814 |
| 4-aryl-5-(4-piperidyl)-3-isoxazolol GABAA antagonists: synthesis, pharmacology, and structure-activity relationships. | Journal of medicinal chemistry 20070419 |
| Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology. | Journal of medicinal chemistry 20060223 |
| Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. | Journal of medicinal chemistry 20050127 |
| GABA(A) agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnotic. | Biochemical pharmacology 20041015 |
| Activation of single heteromeric GABA(A) receptor ion channels by full and partial agonists. | The Journal of physiology 20040601 |
| Design and synthesis of a new series of 4-alkylated 3-isoxazolol GABA A antagonists. | European journal of medicinal chemistry 20030401 |
| Activity of novel 4-PIOL analogues at human alpha 1 beta 2 gamma 2S GABA(A) receptors--correlation with hydrophobicity. | European journal of pharmacology 20020913 |
| GABA(A) receptor ligands and their therapeutic potentials. | Current topics in medicinal chemistry 20020801 |
| Novel class of potent 4-arylalkyl substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. | Journal of medicinal chemistry 20020606 |
| Effects of GABA(A) receptor partial agonists in primary cultures of cerebellar granule neurons and cerebral cortical neurons reflect different receptor subunit compositions. | British journal of pharmacology 20010601 |
| Entropy as the predominant driving force of binding to human recombinant alpha(x)beta(3)gamma(2) GABA(A) receptors. | European journal of pharmacology 20010105 |
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