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Home > Other Building Blocks > 131740-09-5
CAS No: 131740-09-5 Catalog No: AG00385D MDL No:MFCD16876048
Title | Journal |
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Efficacy of RNA polymerase II inhibitors in targeting dormant leukaemia cells. | BMC pharmacology & toxicology 20130101 |
Randomized phase II study of two schedules of flavopiridol given as timed sequential therapy with cytosine arabinoside and mitoxantrone for adults with newly diagnosed, poor-risk acute myelogenous leukemia. | Haematologica 20121101 |
A phase 2 trial of flavopiridol (Alvocidib) and cisplatin in platin-resistant ovarian and primary peritoneal carcinoma: MC0261. | Gynecologic oncology 20121001 |
CDK inhibitors upregulate BH3-only proteins to sensitize human myeloma cells to BH3 mimetic therapies. | Cancer research 20120815 |
ER stress and autophagy: new discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol. | Blood 20120809 |
Outcome of patients with relapsed or refractory chronic lymphocytic leukemia treated with flavopiridol: impact of genetic features. | Leukemia 20120601 |
Phase I trial of the combination of flavopiridol and imatinib mesylate in patients with Bcr-Abl+ hematological malignancies. | Cancer chemotherapy and pharmacology 20120601 |
The cyclin-dependent kinase inhibitor flavopiridol potentiates doxorubicin efficacy in advanced sarcomas: preclinical investigations and results of a phase I dose-escalation clinical trial. | Clinical cancer research : an official journal of the American Association for Cancer Research 20120501 |
Delayed cell cycle pathway modulation facilitates recovery after spinal cord injury. | Cell cycle (Georgetown, Tex.) 20120501 |
A dose-finding, pharmacokinetic and pharmacodynamic study of a novel schedule of flavopiridol in patients with advanced solid tumors. | Investigational new drugs 20120401 |
Flavopiridol induces phosphorylation of AKT in a human glioblastoma cell line, in contrast to siRNA-mediated silencing of Cdk9: Implications for drug design and development. | Cell cycle (Georgetown, Tex.) 20120315 |
CDKI-71, a novel CDK9 inhibitor, is preferentially cytotoxic to cancer cells compared to flavopiridol. | International journal of cancer 20120301 |
Hematologic improvement after flavopiridol treatment of pentostatin and rituximab refractory hairy cell leukemia. | Leukemia & lymphoma 20120301 |
Flavopiridol treatment of patients aged 70 or older with refractory or relapsed chronic lymphocytic leukemia is a feasible and active therapeutic approach. | Haematologica 20120301 |
A mathematical model of cell cycle effects in gastric cancer chemotherapy. | Bulletin of mathematical biology 20120101 |
GSK3β inhibition is involved in the neuroprotective effects of cyclin-dependent kinase inhibitors in neurons. | Pharmacological research 20120101 |
Cyclin-dependent kinase 9 activity regulates neutrophil spontaneous apoptosis. | PloS one 20120101 |
Characterization of cyclin E expression in multiple myeloma and its functional role in seliciclib-induced apoptotic cell death. | PloS one 20120101 |
Preclinical study of treatment response in HCT-116 cells and xenografts with (1) H-decoupled (31) P MRS. | NMR in biomedicine 20111101 |
A phase I pharmacokinetic study of pulse-dose vorinostat with flavopiridol in solid tumors. | Investigational new drugs 20111001 |
Flavopiridol induces BCL-2 expression and represses oncogenic transcription factors in leukemic blasts from adults with refractory acute myeloid leukemia. | Leukemia & lymphoma 20111001 |
The BH3-only protein Noxa is stimulated during apoptosis of chronic lymphocytic leukemia cells triggered by M2YN, a new plant-derived extract. | International journal of oncology 20111001 |
Combining proteasome with cell cycle inhibitors: a dual attack potentially applicable to multiple hematopoietic malignancies. | Expert review of hematology 20111001 |
Risk factors for tumor lysis syndrome in patients with chronic lymphocytic leukemia treated with the cyclin-dependent kinase inhibitor, flavopiridol. | Leukemia 20110901 |
Acute myeloid leukaemia: optimal management and recent developments. | Drugs 20110820 |
Vinblastine sensitizes leukemia cells to cyclin-dependent kinase inhibitors, inducing acute cell cycle phase-independent apoptosis. | Cancer biology & therapy 20110815 |
[Present status and perspective of targeted therapy for B-cell lymphoma]. | [Rinsho ketsueki] The Japanese journal of clinical hematology 20110801 |
Novel purine-based fluoroaryl-1,2,3-triazoles as neuroprotecting agents: synthesis, neuronal cell culture investigations, and CDK5 docking studies. | Bioorganic & medicinal chemistry letters 20110701 |
Leukemia cutis in association With Grover's disease. | The American Journal of dermatopathology 20110601 |
Constitutive Smad linker phosphorylation in melanoma: a mechanism of resistance to transforming growth factor-β-mediated growth inhibition. | Pigment cell & melanoma research 20110601 |
Phase I trial of bortezomib (PS-341; NSC 681239) and alvocidib (flavopiridol; NSC 649890) in patients with recurrent or refractory B-cell neoplasms. | Clinical cancer research : an official journal of the American Association for Cancer Research 20110515 |
Phase 1 and pharmacokinetic study of bolus-infusion flavopiridol followed by cytosine arabinoside and mitoxantrone for acute leukemias. | Blood 20110324 |
Flavopiridol inhibits lipopolysaccharide-induced TNF-α production through inactivation of nuclear factor-κB and mitogen-activated protein kinases in the MyD88-dependent pathway. | Microbiology and immunology 20110301 |
Homology modeling, molecular dynamic simulation and docking studies of cyclin dependent kinase 1. | Journal of molecular modeling 20110201 |
Flavopiridol protects against inflammation by attenuating leukocyte-endothelial interaction via inhibition of cyclin-dependent kinase 9. | Arteriosclerosis, thrombosis, and vascular biology 20110201 |
Early lymphocyte recovery after intensive timed sequential chemotherapy for acute myelogenous leukemia: peripheral oligoclonal expansion of regulatory T cells. | Blood 20110113 |
Chemoproteomics-based kinome profiling and target deconvolution of clinical multi-kinase inhibitors in primary chronic lymphocytic leukemia cells. | Leukemia 20110101 |
The CDK9/cyclin T1 subunits of P-TEFb in mouse oocytes and preimplantation embryos: a possible role in embryonic genome activation. | BMC developmental biology 20110101 |
CDK9 regulates AR promoter selectivity and cell growth through serine 81 phosphorylation. | Molecular endocrinology (Baltimore, Md.) 20101201 |
Assaying pharmacodynamic endpoints with targeted therapy: flavopiridol and 17AAG induced dephosphorylation of histone H1.5 in acute myeloid leukemia. | Proteomics 20101201 |
Combination of vorinostat and flavopiridol is selectively cytotoxic to multidrug-resistant neuroblastoma cell lines with mutant TP53. | Molecular cancer therapeutics 20101201 |
Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo. | Cancer biology & therapy 20101101 |
A phase I clinical trial of FOLFIRI in combination with the pan-cyclin-dependent kinase (CDK) inhibitor flavopiridol. | Cancer chemotherapy and pharmacology 20101101 |
Flavopiridol, the first cyclin-dependent kinase inhibitor: recent advances in combination chemotherapy. | Mini reviews in medicinal chemistry 20101001 |
[Synergism of antitumor effects on ovarian carcinoma using autocatalytic caspase-3 combined with flavopiridol]. | Zhonghua fu chan ke za zhi 20101001 |
P-TEFb kinase complex phosphorylates histone H1 to regulate expression of cellular and HIV-1 genes. | The Journal of biological chemistry 20100924 |
Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells. | Nature cell biology 20100901 |
A phase I study of flavopiridol in combination with gemcitabine and irinotecan in patients with metastatic cancer. | American journal of clinical oncology 20100801 |
Human chorionic gonadotropin up-regulates expression of myeloid cell leukemia-1 protein in human granulosa-lutein cells: implication of corpus luteum rescue and ovarian hyperstimulation syndrome. | The Journal of clinical endocrinology and metabolism 20100801 |
Dinaciclib (SCH 727965), a novel and potent cyclin-dependent kinase inhibitor. | Molecular cancer therapeutics 20100801 |
Preclinical pharmacokinetic/pharmacodynamic models to predict synergistic effects of co-administered anti-cancer agents. | Cancer chemotherapy and pharmacology 20100701 |
Clinical activity of sequential flavopiridol, cytosine arabinoside, and mitoxantrone for adults with newly diagnosed, poor-risk acute myelogenous leukemia. | Leukemia research 20100701 |
T-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4 and 7SK/HEXIM1 regulatory complexes. | Journal of cellular physiology 20100701 |
Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells including those resistant to imatinib treatment. | Biochemical pharmacology 20100701 |
Sequential flavopiridol, mitoxantrone and cytosine arabinoside for newly diagnosed poor risk acute myeloid leukemia. What to do next? | Leukemia research 20100701 |
Phase I clinical and pharmacokinetic study of a novel schedule of flavopiridol in relapsed or refractory acute leukemias. | Haematologica 20100701 |
Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone. | The Journal of pharmacology and experimental therapeutics 20100601 |
Recombinant Leishmania mexicana CRK3:CYCA has protein kinase activity in the absence of phosphorylation on the T-loop residue Thr178. | Molecular and biochemical parasitology 20100601 |
Specificity in the interaction of natural products with their target proteins--a biochemical and structural insight. | Mini reviews in medicinal chemistry 20100601 |
A combination of cisplatin-eluting gelatin microspheres and flavopiridol enhances anti-tumour effects in a rabbit VX2 liver tumour model. | The British journal of radiology 20100501 |
Chemotherapeutic drugs inhibit ribosome biogenesis at various levels. | The Journal of biological chemistry 20100416 |
Dysoxylum binectariferum Hook.f (Meliaceae), a rich source of rohitukine. | Fitoterapia 20100301 |
Flavopiridol, fludarabine, and rituximab in mantle cell lymphoma and indolent B-cell lymphoproliferative disorders. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100120 |
New agents in chronic lymphocytic leukemia. | Current hematologic malignancy reports 20100101 |
The binding of flavopiridol to blood serum albumin. | Chirality 20100101 |
Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition. | PloS one 20100101 |
Potent inhibition of rhabdoid tumor cells by combination of flavopiridol and 4OH-tamoxifen. | BMC cancer 20100101 |
Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically high-risk disease. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091210 |
Phase I study of flavopiridol with oxaliplatin and fluorouracil/leucovorin in advanced solid tumors. | Clinical cancer research : an official journal of the American Association for Cancer Research 20091201 |
Misguided transcriptional elongation causes mixed lineage leukemia. | PLoS biology 20091101 |
Flavopiridol reduces the impedance of neural prostheses in vivo without affecting recording quality. | Journal of neuroscience methods 20091015 |
SKIP interacts with c-Myc and Menin to promote HIV-1 Tat transactivation. | Molecular cell 20091009 |
Emerging therapies for patients with advanced chronic lymphocytic leukaemia. | Blood reviews 20090901 |
New agents in acute myeloid leukemia: beyond cytarabine and anthracyclines. | Current oncology reports 20090901 |
Identification of flavopiridol analogues that selectively inhibit positive transcription elongation factor (P-TEFb) and block HIV-1 replication. | Chembiochem : a European journal of chemical biology 20090817 |
CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processing. | EMBO reports 20090801 |
The effect of the cyclin-dependent kinase inhibitor flavopiridol on anaplastic large cell lymphoma cells and relationship with NPM-ALK kinase expression and activity. | Haematologica 20090701 |
Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia. | Blood 20090507 |
The effect of breast cancer resistance protein and P-glycoprotein on the brain penetration of flavopiridol, imatinib mesylate (Gleevec), prazosin, and 2-methoxy-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)propanoic acid (PF-407288) in mice. | Drug metabolism and disposition: the biological fate of chemicals 20090501 |
Camptothecin releases P-TEFb from the inactive 7SK snRNP complex. | Cell cycle (Georgetown, Tex.) 20090415 |
Transforming growth factor-{beta}-inducible phosphorylation of Smad3. | The Journal of biological chemistry 20090410 |
Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia. | Blood 20090319 |
Targeting MET transcription as a therapeutic strategy in multiple myeloma. | Cancer chemotherapy and pharmacology 20090301 |
Noxa upregulation is associated with apoptosis of chronic lymphocytic leukemia cells induced by hyperforin but not flavopiridol. | Leukemia 20090301 |
Role of the HIV-1 positive elongation factor P-TEFb and inhibitors thereof. | Mini reviews in medicinal chemistry 20090301 |
Retinoblastoma tumor suppressor gene expression determines the response to sequential flavopiridol and doxorubicin treatment in small-cell lung carcinoma. | Clinical cancer research : an official journal of the American Association for Cancer Research 20090215 |
A novel liposomal formulation of flavopiridol. | International journal of pharmaceutics 20090105 |
Circulating tumor cells in HER-2 positive metastatic breast cancer patients treated with trastuzumab and chemotherapy. | The International journal of biological markers 20090101 |
A phase II study of flavopiridol (Alvocidib) in combination with docetaxel in refractory, metastatic pancreatic cancer. | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20090101 |
Flavopiridol in chronic lymphocytic leukemia: a concise review. | Clinical lymphoma & myeloma 20090101 |
Future research directions for the treatment of AML. | Clinical advances in hematology & oncology : H&O 20081101 |
Development and validation of a highly sensitive liquid chromatography/mass spectrometry method for simultaneous quantification of lenalidomide and flavopiridol in human plasma. | Therapeutic drug monitoring 20081001 |
Combinatorial antileukemic disruption of oxidative homeostasis and mitochondrial stability by the redox reactive thalidomide 2-(2,4-difluoro-phenyl)-4,5,6,7-tetrafluoro-1H-isoindole-1,3(2H)-dione (CPS49) and flavopiridol. | Molecular pharmacology 20080901 |
Flavopiridol potentiates the cytotoxic effects of radiation in radioresistant tumor cells in which p53 is mutated or Bcl-2 is overexpressed. | International journal of radiation oncology, biology, physics 20080801 |
Novel agents in chronic lymphocytic leukemia: efficacy and tolerability of new therapies. | Clinical lymphoma & myeloma 20080801 |
The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation. | The EMBO journal 20080709 |
Development and validation of a sensitive liquid chromatography/mass spectrometry method for quantitation of flavopiridol in plasma enables accurate estimation of pharmacokinetic parameters with a clinically active dosing schedule. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080601 |
Flavopiridol-induced iNOS downregulation during apoptosis of chronic lymphocytic leukemia cells is caspase-dependent. | Leukemia research 20080501 |
Delayed combinatorial treatment with flavopiridol and minocycline provides longer term protection for neuronal soma but not dendrites following global ischemia. | Journal of neurochemistry 20080501 |
Flavopiridol suppresses tumor necrosis factor-induced activation of activator protein-1, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase (MAPK), p44/p42 MAPK, and Akt, inhibits expression of antiapoptotic gene products, and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells. | Molecular pharmacology 20080501 |
Phase I study of flavopiridol in combination with Paclitaxel and Carboplatin in patients with non-small-cell lung cancer. | Clinical lung cancer 20080501 |
Flavopiridol displays preclinical activity in acute lymphoblastic leukemia. | Pediatric blood & cancer 20080401 |
The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner. | Cancer research 20080401 |
Flavopiridol causes early mitochondrial damage in chronic lymphocytic leukemia cells with impaired oxygen consumption and mobilization of intracellular calcium. | Blood 20080315 |
P-TEFb inhibitors interfere with activation of p53 by DNA-damaging agents. | Oncogene 20080221 |
Successful treatment of animal models of rheumatoid arthritis with small-molecule cyclin-dependent kinase inhibitors. | Journal of immunology (Baltimore, Md. : 1950) 20080201 |
Transcription-dependent gene looping of the HIV-1 provirus is dictated by recognition of pre-mRNA processing signals. | Molecular cell 20080118 |
Rhabdoid tumor growth is inhibited by flavopiridol. | Clinical cancer research : an official journal of the American Association for Cancer Research 20080115 |
The functional role of an interleukin 6-inducible CDK9.STAT3 complex in human gamma-fibrinogen gene expression. | The Journal of biological chemistry 20071221 |
Lack of association between common polymorphisms in UGT1A9 and gene expression and activity. | Drug metabolism and disposition: the biological fate of chemicals 20071201 |
Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells. | Molecular cancer therapeutics 20071201 |
Cell cycle activation contributes to post-mitotic cell death and secondary damage after spinal cord injury. | Brain : a journal of neurology 20071101 |
Flavopiridol in the treatment of chronic lymphocytic leukemia. | Current opinion in oncology 20071101 |
[Therapeutic effect of flavopiridol, a small molecular cyclin-dependent kinase inhibitor, in human ovarian carcinoma]. | Zhonghua fu chan ke za zhi 20071101 |
Phase I dose-finding study of weekly docetaxel followed by flavopiridol for patients with advanced solid tumors. | Clinical cancer research : an official journal of the American Association for Cancer Research 20071001 |
Cyclin-dependent kinase inhibitor, flavopiridol, induces apoptosis and inhibits tumor growth in drug-resistant osteosarcoma and Ewing's family tumor cells. | International journal of cancer 20070915 |
Novel agents and strategies for treatment of p53-defective chronic lymphocytic leukemia. | Best practice & research. Clinical haematology 20070901 |
Flavopiridol synergizes TRAIL cytotoxicity by downregulation of FLIPL. | Cancer chemotherapy and pharmacology 20070801 |
UGT1A1*28 genotype affects the in-vitro glucuronidation of thyroxine in human livers. | Pharmacogenetics and genomics 20070801 |
Sequential flavopiridol, cytosine arabinoside, and mitoxantrone: a phase II trial in adults with poor-risk acute myelogenous leukemia. | Clinical cancer research : an official journal of the American Association for Cancer Research 20070801 |
[DMF induces apoptosis in human androgen-independent prostate cancer PC3 cells in vitro]. | Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20070501 |
[Research on cyclin-dependent kinase inhibitors: state of the art and perspective]. | Zhonghua zhong liu za zhi [Chinese journal of oncology] 20070501 |
In vitro cytotoxicity of nelarabine, clofarabine and flavopiridol in paediatric acute lymphoblastic leukaemia. | British journal of haematology 20070401 |
Levels of p27(kip1) determine Aplidin sensitivity. | Molecular cancer therapeutics 20070401 |
Small molecule inhibitors of Stat3 signaling pathway. | Current cancer drug targets 20070201 |
Mechanism and functional role of XIAP and Mcl-1 down-regulation in flavopiridol/vorinostat antileukemic interactions. | Molecular cancer therapeutics 20070201 |
Timed-sequential chemotherapy as induction and/or consolidation regimen for younger adults with acute myelogenous leukemia. | Hematology (Amsterdam, Netherlands) 20070201 |
Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia. | Blood 20070115 |
Design, synthesis, and antiproliferative and CDK2-cyclin a inhibitory activity of novel flavopiridol analogues. | Bioorganic & medicinal chemistry 20070115 |
Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complex. | Retrovirology 20070101 |
Bioactivity of glycogen phosphorylase inhibitors that bind to the purine nucleoside site. | Bioorganic & medicinal chemistry 20061201 |
Transcriptional profiling identifies cyclin D1 as a critical downstream effector of mutant epidermal growth factor receptor signaling. | Cancer research 20061201 |
A sequential blockade strategy for the design of combination therapies to overcome oncogene addiction in chronic myelogenous leukemia. | Cancer research 20061115 |
Induction of apoptosis and down regulation of cell cycle proteins in mantle cell lymphoma by flavopiridol treatment. | Leukemia research 20061101 |
Antisense inhibition of cyclin D1 expression is equivalent to flavopiridol for radiosensitization of zebrafish embryos. | International journal of radiation oncology, biology, physics 20061001 |
Sequential combinations of flavopiridol and docetaxel inhibit prostate tumors, induce apoptosis, and decrease angiogenesis in the Ggamma/T-15 transgenic mouse model of prostate cancer. | The Prostate 20061001 |
Efficacy of sequential treatment of HCT116 colon cancer monolayers and xenografts with docetaxel, flavopiridol, and 5-fluorouracil. | Acta pharmacologica Sinica 20061001 |
Combined depletion of cell cycle and transcriptional cyclin-dependent kinase activities induces apoptosis in cancer cells. | Cancer research 20060915 |
Pharmacological induction of Hsp70 protects apoptosis-prone cells from doxorubicin: comparison with caspase-inhibitor- and cycle-arrest-mediated cytoprotection. | Cell death and differentiation 20060901 |
Flavopiridol induces cellular FLICE-inhibitory protein degradation by the proteasome and promotes TRAIL-induced early signaling and apoptosis in breast tumor cells. | Cancer research 20060901 |
The cyclin-dependent kinase inhibitor flavopiridol sensitizes human hepatocellular carcinoma cells to TRAIL-induced apoptosis. | International journal of molecular medicine 20060801 |
Improvement of esophageal adenocarcinoma cell and xenograft responses to radiation by targeting cyclin-dependent kinases. | Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20060801 |
Alvocidib (Flavopiridol) suppresses tumor growth in SCID mice with human esophageal cancer xenografts without inducing apoptosis. | Surgical oncology 20060801 |
MicroRNAs in leukemia. | Clinical advances in hematology & oncology : H&O 20060801 |
A phase I study of flavopiridol and docetaxel. | Investigational new drugs 20060701 |
Cyclin dependent kinase inhibitors prevent apoptosis of postmitotic mouse motoneurons. | Life sciences 20060627 |
Flavopiridol targets c-KIT transcription and induces apoptosis in gastrointestinal stromal tumor cells. | Cancer research 20060601 |
Sequential combination of flavopiridol and docetaxel reduces the levels of X-linked inhibitor of apoptosis and AKT proteins and stimulates apoptosis in human LNCaP prostate cancer cells. | Molecular cancer therapeutics 20060501 |
The reversibility of mitotic exit in vertebrate cells. | Nature 20060413 |
The first metal-based paullone derivative with high antiproliferative activity in vitro. | Inorganic chemistry 20060306 |
Flavopiridol in patients with relapsed or refractory multiple myeloma: a phase 2 trial with clinical and pharmacodynamic end-points. | Haematologica 20060301 |
Flavopiridol and histone deacetylase inhibitors promote mitochondrial injury and cell death in human leukemia cells that overexpress Bcl-2. | Molecular pharmacology 20060101 |
Radiation sensitivity of GL261 murine glioma model and enhanced radiation response by flavopiridol. | Cell cycle (Georgetown, Tex.) 20060101 |
Dual action of the inhibitors of cyclin-dependent kinases: targeting of the cell-cycle progression and activation of wild-type p53 protein. | Expert opinion on investigational drugs 20060101 |
Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy. | Molecular cancer therapeutics 20060101 |
A common protein fold topology shared by flavonoid biosynthetic enzymes and therapeutic targets. | Journal of natural products 20060101 |
Effects of PRIMA-1 on wild-type L1210 cells expressing mutant p53 and drug-resistant L1210 cells lacking expression of p53: necrosis vs. apoptosis. | Anticancer research 20060101 |
Potential use of pharmacological cyclin-dependent kinase inhibitors as anti-HIV therapeutics. | Current pharmaceutical design 20060101 |
Phase I clinical and pharmacokinetic study of flavopiridol in children with refractory solid tumors: a Children's Oncology Group Study. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20051220 |
Indirubin-3'-monoxime, a derivative of a Chinese antileukemia medicine, inhibits P-TEFb function and HIV-1 replication. | AIDS (London, England) 20051202 |
Phase I and pharmacokinetic study of flavopiridol followed by 1-beta-D-arabinofuranosylcytosine and mitoxantrone in relapsed and refractory adult acute leukemias. | Clinical cancer research : an official journal of the American Association for Cancer Research 20051201 |
Flavopiridol administered as a 24-hour continuous infusion in chronic lymphocytic leukemia lacks clinical activity. | Leukemia research 20051101 |
Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death. | Blood 20051001 |
Role of the cell cycle in the pathobiology of central nervous system trauma. | Cell cycle (Georgetown, Tex.) 20050901 |
Phase 1 trial of flavopiridol combined with cisplatin or carboplatin in patients with advanced malignancies with the assessment of pharmacokinetic and pharmacodynamic end points. | Clinical cancer research : an official journal of the American Association for Cancer Research 20050815 |
A phase II evaluation of flavopiridol as second-line chemotherapy of endometrial carcinoma: a Gynecologic Oncology Group study. | Gynecologic oncology 20050801 |
A study of cytotoxic synergy of UCN-01 and flavopiridol in syngeneic pair of cell lines. | Investigational new drugs 20050801 |
A noninvasive approach for assessing tumor hypoxia in xenografts: developing a urinary marker for hypoxia. | Cancer research 20050715 |
Accumulation of hypoxia-inducible factor-1alpha is limited by transcription-dependent depletion. | Oncogene 20050714 |
A phase II study of flavopiridol in patients with advanced renal cell carcinoma: results of Southwest Oncology Group Trial 0109. | Cancer chemotherapy and pharmacology 20050701 |
Flavopiridol downregulates hypoxia-mediated hypoxia-inducible factor-1alpha expression in human glioma cells by a proteasome-independent pathway: implications for in vivo therapy. | Neuro-oncology 20050701 |
Induction of apoptosis by flavopiridol unrelated to cell cycle arrest in germ cell tumour derived cell lines. | Investigational new drugs 20050601 |
Chronic lymphocytic leukemia: a niche for flavopiridol? | Clinical cancer research : an official journal of the American Association for Cancer Research 20050601 |
Treatment of relapsed chronic lymphocytic leukemia by 72-hour continuous infusion or 1-hour bolus infusion of flavopiridol: results from Cancer and Leukemia Group B study 19805. | Clinical cancer research : an official journal of the American Association for Cancer Research 20050601 |
A phase I clinical trial of the sequential combination of irinotecan followed by flavopiridol. | Clinical cancer research : an official journal of the American Association for Cancer Research 20050515 |
Drugging cell cycle kinases in cancer therapy. | Current drug targets 20050501 |
Flavopiridol sensitivity of cancer cells isolated from ascites and pleural fluids. | Clinical cancer research : an official journal of the American Association for Cancer Research 20050501 |
Cooperation between Cdk4 and p27kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity. | Cancer research 20050501 |
Kinase-addiction and bi-phasic sensitivity-resistance of Bcr-Abl- and Raf-1-expressing cells to imatinib and geldanamycin. | Cancer biology & therapy 20050401 |
Recent progress in the discovery and development of cyclin-dependent kinase inhibitors. | Expert opinion on investigational drugs 20050401 |
[A novel small molecule cyclin-dependent kinase inhibitor flavopiridol in cancer therapy]. | Zhonghua yi xue za zhi 20050330 |
Flavopiridol reduces malignant transformation of the esophageal mucosa in p27 knockout mice. | Oncogene 20050303 |
Flavopiridol blocks integrin-mediated survival in dormant breast cancer cells. | Clinical cancer research : an official journal of the American Association for Cancer Research 20050301 |
Sequence dependent potentiation of gemcitabine by flavopiridol in human breast cancer cells. | Breast cancer research and treatment 20050301 |
Combination therapy for adult T-cell leukemia-xenografted mice: flavopiridol and anti-CD25 monoclonal antibody. | Blood 20050201 |
Blockage of cyclin cdk's, PKC and phosphoinositol 3-kinase pathways leads to augmentation of apoptosis in drug-resistant leukemia cells: evidence for interactive effects of flavopiridol, LY 294002, roscovitine,wortmannin and UCN-01. | Anticancer research 20050101 |
Inhibition of multiple pathways accounts for the antiapoptotic effects of flavopiridol on potassium withdrawal-induced apoptosis in neurons. | Journal of molecular neuroscience : MN 20050101 |
New concepts in the treatment of acute myeloid malignancies: selected pathways for targeted therapy. | Journal of biological regulators and homeostatic agents 20050101 |
Inhibitors of cyclin-dependent kinase modulators for cancer therapy. | Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques 20050101 |
Flavopiridol, an inhibitor of cyclin-dependent kinases, induces growth inhibition and apoptosis in bladder cancer cells in vitro and in vivo. | Anticancer research 20050101 |
Induction of apoptosis by flavopiridol in human neuroblastoma cells is enhanced under hypoxia and associated with N-myc proto-oncogene down-regulation. | Clinical cancer research : an official journal of the American Association for Cancer Research 20041215 |
Cyclooxygenase-2 activity contributes to neuronal expression of cyclin D1 after anoxia/ischemia in vitro and in vivo. | Brain research. Molecular brain research 20041206 |
Flavopiridol, an inhibitor of transcription: implications, problems and solutions. | Cell cycle (Georgetown, Tex.) 20041201 |
E2F4 deficiency promotes drug-induced apoptosis. | Cancer biology & therapy 20041201 |
The small-molecule Bcl-2 inhibitor HA14-1 interacts synergistically with flavopiridol to induce mitochondrial injury and apoptosis in human myeloma cells through a free radical-dependent and Jun NH2-terminal kinase-dependent mechanism. | Molecular cancer therapeutics 20041201 |
Molecular models of cyclin-dependent kinase 1 complexed with inhibitors. | Biochemical and biophysical research communications 20041112 |
Potent antileukemic interactions between flavopiridol and TRAIL/Apo2L involve flavopiridol-mediated XIAP downregulation. | Leukemia 20041101 |
Contribution of disruption of the nuclear factor-kappaB pathway to induction of apoptosis in human leukemia cells by histone deacetylase inhibitors and flavopiridol. | Molecular pharmacology 20041001 |
Phase II trial of flavopiridol, a cyclin dependent kinase inhibitor, in untreated metastatic malignant melanoma. | Investigational new drugs 20040801 |
Local cyclin-dependent kinase inhibition by flavopiridol inhibits coronary artery smooth muscle cell proliferation and migration: Implications for the applicability on drug-eluting stents to prevent neointima formation following vascular injury. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040801 |
Phase I trial of the cyclin-dependent kinase inhibitor flavopiridol in combination with docetaxel in patients with metastatic breast cancer. | Clinical cancer research : an official journal of the American Association for Cancer Research 20040801 |
Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms. | Blood 20040715 |
Flavopiridol increases therapeutic ratio of radiotherapy by preferentially enhancing tumor radioresponse. | International journal of radiation oncology, biology, physics 20040715 |
Transcriptional signature of flavopiridol-induced tumor cell death. | Molecular cancer therapeutics 20040701 |
Gene profiling and the cyclin-dependent kinase inhibitor flavopiridol: what's in a name? | Molecular cancer therapeutics 20040701 |
Preclinical and clinical development of the cyclin-dependent kinase inhibitor flavopiridol. | Clinical cancer research : an official journal of the American Association for Cancer Research 20040615 |
Neutropenic enterocolitis (typhilitis) associated with docetaxel therapy in a patient with non-small-cell lung cancer: case report and review of literature. | Lung cancer (Amsterdam, Netherlands) 20040601 |
Binding of the potential antitumour agent indirubin-5-sulphonate at the inhibitor site of rabbit muscle glycogen phosphorylase b. Comparison with ligand binding to pCDK2-cyclin A complex. | European journal of biochemistry 20040601 |
Flavopiridol: pleiotropic biological effects enhance its anti-cancer activity. | Anti-cancer drugs 20040601 |
Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells. | Cancer research 20040515 |
Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and, independently of p53, sensitizes apoptosis-reluctant cells to tumor necrosis factor. | Cancer research 20040515 |
Growth inhibition and induction of apoptosis by flavopiridol in rat lung adenocarcinoma, osteosarcoma and malignant fibrous histiocytoma cell lines. | Oncology reports 20040501 |
Enhancement of radiation effects by combined docetaxel and flavopiridol treatment in lung cancer cells. | Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20040501 |
Flavopiridol enhances human tumor cell radiosensitivity and prolongs expression of gammaH2AX foci. | Molecular cancer therapeutics 20040401 |
Combining flavopiridol with various signal transduction inhibitors. | Oncology reports 20040301 |
Evidence of a functional role for p21WAF1/CIP1 down-regulation in synergistic antileukemic interactions between the histone deacetylase inhibitor sodium butyrate and flavopiridol. | Molecular pharmacology 20040301 |
Abrogation of p21 expression by flavopiridol enhances depsipeptide-mediated apoptosis in malignant pleural mesothelioma cells. | Clinical cancer research : an official journal of the American Association for Cancer Research 20040301 |
Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9. | The Journal of biological chemistry 20040206 |
Inhibition of cell cycle pathway by flavopiridol promotes survival of cerebellar granule cells after an excitotoxic treatment. | The Journal of pharmacology and experimental therapeutics 20040201 |
Flavopiridol: where do we stand in chronic lymphocytic leukemia? | Leukemia 20040201 |
Flavopiridol inhibits the growth of GL261 gliomas in vivo: implications for malignant glioma therapy. | Cell cycle (Georgetown, Tex.) 20040201 |
A Phase II trial of flavopiridol (NSC #649890) in patients with previously untreated metastatic androgen-independent prostate cancer. | Clinical cancer research : an official journal of the American Association for Cancer Research 20040201 |
Coordination of transcription, RNA processing, and surveillance by P-TEFb kinase on heat shock genes. | Molecular cell 20040116 |
A novel approach to develop anti-HIV drugs: adapting non-nucleoside anticancer chemotherapeutics. | Antiviral research 20040101 |
Cell-cycle targeted therapies. | The Lancet. Oncology 20040101 |
Flavopiridol as a radio-sensitizer for esophageal cancer cell lines. | Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 20040101 |
Gemcitabine-induced apoptosis in a drug-resistant mouse leukemia L1210 cell line that does not express p53. | Advances in enzyme regulation 20040101 |
In vitro cell growth pharmacodynamic studies: a new nonparametric approach to determining the relative importance of drug concentration and treatment time. | Cancer chemotherapy and pharmacology 20031201 |
Flavopiridol downregulates the expression of both the inducible NO synthase and p27(kip1) in malignant cells from B-cell chronic lymphocytic leukemia. | Leukemia 20031201 |
The cyclin-dependent kinase inhibitor flavopiridol potentiates gamma-irradiation-induced apoptosis in colon and gastric cancer cells. | Clinical cancer research : an official journal of the American Association for Cancer Research 20031201 |
The role of hepatic Mrp2 in the interaction of flavopiridol and bilirubin: impact on therapy. | International journal of clinical pharmacology and therapeutics 20031201 |
The inducible NO synthase is downregulated during apoptosis of malignant cells from B-cell chronic lymphocytic leukemia induced by flavopiridol and polyphenols. | Annals of the New York Academy of Sciences 20031201 |
Inhibition of CDKs: a strategy for preventing kainic acid-induced apoptosis in neurons. | Annals of the New York Academy of Sciences 20031201 |
Acquired cellular resistance to flavopiridol in a human colon carcinoma cell line involves up-regulation of the telomerase catalytic subunit and telomere elongation. Sensitivity of resistant cells to combination treatment with a telomerase inhibitor. | Molecular pharmacology 20031101 |
Flavopiridol-induced apoptosis during S phase requires E2F-1 and inhibition of cyclin A-dependent kinase activity. | Cancer research 20031101 |
Biliary excretion of flavopiridol and its glucuronides in the isolated perfused rat liver: role of multidrug resistance protein 2 (Mrp2). | Life sciences 20031017 |
Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPK/JNK- and NF-kappaB-dependent process. | Oncogene 20031016 |
Neuroprotective action of flavopiridol, a cyclin-dependent kinase inhibitor, in colchicine-induced apoptosis. | Neuropharmacology 20031001 |
Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs. | The Journal of pharmacology and experimental therapeutics 20031001 |
Clinical pharmacology of flavopiridol following a 72-hour continuous infusion. | The Annals of pharmacotherapy 20031001 |
Flavopiridol potently induces small cell lung cancer apoptosis during S phase in a manner that involves early mitochondrial dysfunction. | Clinical cancer research : an official journal of the American Association for Cancer Research 20031001 |
Quantitative analysis of breast cancer resistance protein and cellular resistance to flavopiridol in acute leukemia patients. | Clinical cancer research : an official journal of the American Association for Cancer Research 20030815 |
Phase II study of flavopiridol in patients with advanced colorectal cancer. | Annals of oncology : official journal of the European Society for Medical Oncology 20030801 |
Cyclin-dependent kinase inhibitors. | Current opinion in pharmacology 20030801 |
A computational model of binding thermodynamics: the design of cyclin-dependent kinase 2 inhibitors. | Journal of medicinal chemistry 20030717 |
Novel direct and indirect cyclin-dependent kinase modulators for the prevention and treatment of human neoplasms. | Cancer chemotherapy and pharmacology 20030701 |
Epidermal growth factor receptor expression is a candidate target of the synergistic combination of trastuzumab and flavopiridol in breast cancer. | Cancer research 20030701 |
Flavopiridol, a cyclin-dependent kinase inhibitor, enhances radiosensitivity of ovarian carcinoma cells. | Cancer research 20030615 |
Commentary: effect of flavonoids on normal and leukemic cells. | Leukemia research 20030601 |
Flavonoid effects on normal and leukemic cells. | Leukemia research 20030601 |
The effect of flavopiridol on the growth of p16+ and p16- melanoma cell lines. | Melanoma research 20030601 |
Flavopiridol enhances the effect of docetaxel in vitro and in vivo in human gastric cancer cells. | Molecular cancer therapeutics 20030601 |
Flavopiridol in untreated or relapsed mantle-cell lymphoma: results of a phase II study of the National Cancer Institute of Canada Clinical Trials Group. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030501 |
Enhancement of depsipeptide-mediated apoptosis of lung or esophageal cancer cells by flavopiridol: activation of the mitochondria-dependent death-signaling pathway. | The Journal of thoracic and cardiovascular surgery 20030501 |
The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process. | Cancer research 20030415 |
Amelioration of nephropathy in mice expressing HIV-1 genes by the cyclin-dependent kinase inhibitor flavopiridol. | The Journal of antimicrobial chemotherapy 20030401 |
Cyclin-dependent kinase activity is required for apoptotic death but not inclusion formation in cortical neurons after proteasomal inhibition. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030215 |
Rapid induction of apoptosis by combination of flavopiridol and tumor necrosis factor (TNF)-alpha or TNF-related apoptosis-inducing ligand in human cancer cell lines. | Cancer research 20030201 |
Clinical pharmacology and pharmacogenetics of flavopiridol 1-h i.v. infusion in patients with refractory neoplasms. | Anti-cancer drugs 20030201 |
Flavopiridol-related proinflammatory syndrome is associated with induction of interleukin-6. | Clinical cancer research : an official journal of the American Association for Cancer Research 20030201 |
Flavopiridol induces apoptosis in glioma cell lines independent of retinoblastoma and p53 tumor suppressor pathway alterations by a caspase-independent pathway. | Molecular cancer therapeutics 20030201 |
Flavopiridol induces apoptosis in B-cell chronic lymphocytic leukaemia cells through a p38 and ERK MAP kinase-dependent mechanism. | Leukemia & lymphoma 20030201 |
Flavopiridol, a cyclin dependent kinase (CDK) inhibitor, induces apoptosis by regulating Bcl-x in oral cancer cells. | Oral oncology 20030101 |
Flavopiridol down-regulates antiapoptotic proteins and sensitizes human breast cancer cells to epothilone B-induced apoptosis. | Cancer research 20030101 |
Suppression of survivin phosphorylation on Thr34 by flavopiridol enhances tumor cell apoptosis. | Cancer research 20030101 |
Flavopiridol-induced apoptosis is mediated through up-regulation of E2F1 and repression of Mcl-1. | Molecular cancer therapeutics 20030101 |
Protein kinase C-dependent activation of the tumor necrosis factor receptor-mediated extrinsic cell death pathway underlies enhanced apoptosis in human myeloid leukemia cells exposed to bryostatin 1 and flavopiridol. | Molecular cancer therapeutics 20030101 |
Timed sequential therapy of acute leukemia with flavopiridol: in vitro model for a phase I clinical trial. | Clinical cancer research : an official journal of the American Association for Cancer Research 20030101 |
Cyclin-dependent kinase modulators studied at the NCI: pre-clinical and clinical studies. | Current medicinal chemistry. Anti-cancer agents 20030101 |
Leukemic and non-leukemic lymphocytes from patients with Li Fraumeni syndrome demonstrate loss of p53 function, Bcl-2 family dysregulation and intrinsic resistance to conventional chemotherapeutic drugs but not flavopiridol. | Cell cycle (Georgetown, Tex.) 20030101 |
Flavopiridol induces mitochondrial-mediated apoptosis in murine glioma GL261 cells via release of cytochrome c and apoptosis inducing factor. | Cell cycle (Georgetown, Tex.) 20030101 |
Irinotecan in metastatic colorectal cancer: dose intensification and combination with new agents, including biological response modifiers. | Annals of oncology : official journal of the European Society for Medical Oncology 20030101 |
c-Myc oncoprotein: cell cycle-related events and new therapeutic challenges in cancer and cardiovascular diseases. | Cell cycle (Georgetown, Tex.) 20030101 |
Phase I clinical and pharmacokinetic trial of the cyclin-dependent kinase inhibitor flavopiridol. | Cancer chemotherapy and pharmacology 20021201 |
The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1. | Clinical cancer research : an official journal of the American Association for Cancer Research 20021101 |
Zebrafish: a preclinical model for drug screening. | Assay and drug development technologies 20021101 |
Phase I clinical and pharmacokinetic study of flavopiridol administered as a daily 1-hour infusion in patients with advanced neoplasms. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20021001 |
Cyclin-dependent kinases as new targets for the prevention and treatment of cancer. | Hematology/oncology clinics of North America 20021001 |
A high-performance liquid chromatography method using ultraviolet detection for the quantitation of flavopiridol from human plasma. | Biomedical chromatography : BMC 20020901 |
Flavopiridol potentiates STI571-induced mitochondrial damage and apoptosis in BCR-ABL-positive human leukemia cells. | Clinical cancer research : an official journal of the American Association for Cancer Research 20020901 |
Clinical trials referral resource. Flavopiridol. | Oncology (Williston Park, N.Y.) 20020901 |
Hematologic malignancies: new developments and future treatments. | Seminars in oncology 20020801 |
Drg1, a novel target for modulating sensitivity to CPT-11 in colon cancer cells. | Cancer research 20020715 |
Synergistic induction of mitochondrial damage and apoptosis in human leukemia cells by flavopiridol and the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA). | Leukemia 20020701 |
Flavopiridol and trastuzumab synergistically inhibit proliferation of breast cancer cells: association with selective cooperative inhibition of cyclin D1-dependent kinase and Akt signaling pathways. | Molecular cancer therapeutics 20020701 |
Flavopiridol inhibits vascular endothelial growth factor production induced by hypoxia or picolinic acid in human neuroblastoma. | International journal of cancer 20020610 |
Synergistic induction of apoptosis in human myeloid leukemia cells by phorbol 12-myristate 13-acetate and flavopiridol proceeds via activation of both the intrinsic and tumor necrosis factor-mediated extrinsic cell death pathways. | Molecular pharmacology 20020601 |
Review of flavopiridol, a cyclin-dependent kinase inhibitor, as breast cancer therapy. | Seminars in oncology 20020601 |
Role of cyclooxygenase-2 in neuronal cell cycle activity and glutamate-mediated excitotoxicity. | The Journal of pharmacology and experimental therapeutics 20020501 |
Flavopiridol, a novel cyclin-dependent kinase inhibitor, in clinical development. | The Annals of pharmacotherapy 20020501 |
Evidence for CRK3 participation in the cell division cycle of Trypanosoma cruzi. | Molecular and biochemical parasitology 20020501 |
In vitro characterization of hepatic flavopiridol metabolism using human liver microsomes and recombinant UGT enzymes. | Pharmaceutical research 20020501 |
Structural basis for inhibition of cyclin-dependent kinase 9 by flavopiridol. | Biochemical and biophysical research communications 20020426 |
Structure-based design and synthesis of 2-benzylidene-benzofuran-3-ones as flavopiridol mimics. | Journal of medicinal chemistry 20020425 |
Rate-limiting effects of Cyclin D1 in transformation by ErbB2 predicts synergy between herceptin and flavopiridol. | Cancer research 20020415 |
Phase I study of the cyclin-dependent kinase inhibitor flavopiridol in combination with paclitaxel in patients with advanced solid tumors. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020415 |
Seventy-two hour continuous infusion flavopiridol in relapsed and refractory mantle cell lymphoma. | Leukemia & lymphoma 20020401 |
Selective sensitization of transformed cells to flavopiridol-induced apoptosis following recruitment to S-phase. | Cancer research 20020315 |
Growth inhibition and apoptosis of myeloma cells by the CDK inhibitor flavopiridol. | Leukemia research 20020301 |
Prevalent loss of mitotic spindle checkpoint in adult T-cell leukemia confers resistance to microtubule inhibitors. | The Journal of biological chemistry 20020215 |
Inhibition of cyclin-dependent kinases improves CA1 neuronal survival and behavioral performance after global ischemia in the rat. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20020201 |
The cyclin-dependent kinase inhibitor flavopiridol disrupts sodium butyrate-induced p21WAF1/CIP1 expression and maturation while reciprocally potentiating apoptosis in human leukemia cells. | Molecular cancer therapeutics 20020201 |
The cell cycle as a target for cancer therapy: basic and clinical findings with the small molecule inhibitors flavopiridol and UCN-01. | The oncologist 20020101 |
Loss of the Bcl-2 phosphorylation loop domain is required to protect human myeloid leukemia cells from flavopiridol-mediated mitochondrial damage and apoptosis. | Cancer biology & therapy 20020101 |
[Report on 93rd AACR]. | Bulletin du cancer 20020101 |
CDK inhibitors: cell cycle arrest versus apoptosis. | Cell cycle (Georgetown, Tex.) 20020101 |
Flavopiridol inversely affects p21(WAF1/CIP1) and p53 and protects p21-sensitive cells from paclitaxel. | Cancer biology & therapy 20020101 |
Role reversal for anticancer agents. | Cancer biology & therapy 20020101 |
Suppression of HIV-1 expression by inhibitors of cyclin-dependent kinases promotes differentiation of infected podocytes. | Journal of the American Society of Nephrology : JASN 20011201 |
Augmentation of apoptosis and tumor regression by flavopiridol in the presence of CPT-11 in Hct116 colon cancer monolayers and xenografts. | Clinical cancer research : an official journal of the American Association for Cancer Research 20011201 |
Characterization of a human colorectal carcinoma cell line with acquired resistance to flavopiridol. | Molecular pharmacology 20011101 |
Microtubule-targeting drugs induce bcl-2 phosphorylation and association with Pin1. | Neoplasia (New York, N.Y.) 20011101 |
Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo. | The Journal of biological chemistry 20010824 |
Flavopiridol increases sensitization to gemcitabine in human gastrointestinal cancer cell lines and correlates with down-regulation of ribonucleotide reductase M2 subunit. | Clinical cancer research : an official journal of the American Association for Cancer Research 20010801 |
Flavopiridol. National Cancer Institute. | Current opinion in investigational drugs (London, England : 2000) 20010801 |
The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in human leukemia cells (U937) through the mitochondrial rather than the receptor-mediated pathway. | Cell death and differentiation 20010701 |
Flavopiridol circumvents Bcl-2 family mediated inhibition of apoptosis and drug resistance in B-cell chronic lymphocytic leukaemia. | British journal of haematology 20010701 |
A phase II trial of the cyclin-dependent kinase inhibitor flavopiridol in patients with previously untreated stage IV non-small cell lung cancer. | Clinical cancer research : an official journal of the American Association for Cancer Research 20010601 |
Treatment with inhibitors of caspases, that are substrates of drug transporters, selectively permits chemotherapy-induced apoptosis in multidrug-resistant cells but protects normal cells. | Leukemia 20010601 |
Mechanisms of action of flavopiridol. | Critical reviews in oncology/hematology 20010501 |
Characterization of autoantibodies against uridine-diphosphate glucuronosyltransferase in patients with inflammatory liver diseases. | Hepatology (Baltimore, Md.) 20010501 |
Effect of P-glycoprotein on flavopiridol sensitivity. | British journal of cancer 20010501 |
The CRK3 protein kinase is essential for cell cycle progression of Leishmania mexicana. | Molecular and biochemical parasitology 20010406 |
In vitro glucuronidation of the cyclin-dependent kinase inhibitor flavopiridol by rat and human liver microsomes: involvement of UDP-glucuronosyltransferases 1A1 and 1A9. | Drug metabolism and disposition: the biological fate of chemicals 20010401 |
Phase II study of the cyclin-dependent kinase inhibitor flavopiridol administered to patients with advanced gastric carcinoma. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010401 |
[CDK inhibitors for therapy of cancer]. | Nihon rinsho. Japanese journal of clinical medicine 20010401 |
Selective sensitization of retinoblastoma protein-deficient sarcoma cells to doxorubicin by flavopiridol-mediated inhibition of cyclin-dependent kinase 2 kinase activity. | Cancer research 20010315 |
The cyclin-dependent kinase inhibitor (CDKI) flavopiridol disrupts phorbol 12-myristate 13-acetate-induced differentiation and CDKI expression while enhancing apoptosis in human myeloid leukemia cells. | Cancer research 20010315 |
Characterization of the Trypanosoma cruzi Cdc2p-related protein kinase 1 and identification of three novel associating cyclins. | Molecular and biochemical parasitology 20010301 |
The cyclin-dependent kinase (CDK) inhibitor flavopiridol inhibits glycogen phosphorylase. | Archives of biochemistry and biophysics 20010215 |
Possible mechanisms of diarrheal side effects associated with the use of a novel chemotherapeutic agent, flavopiridol. | Clinical cancer research : an official journal of the American Association for Cancer Research 20010201 |
Strategies to circumvent SV40 oncoprotein expression in malignant pleural mesotheliomas. | Seminars in cancer biology 20010201 |
Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? | The Journal of biological chemistry 20010105 |
Overexpression of the ATP-binding cassette half-transporter, ABCG2 (Mxr/BCrp/ABCP1), in flavopiridol-resistant human breast cancer cells. | Clinical cancer research : an official journal of the American Association for Cancer Research 20010101 |
Development of cyclin-dependent kinase modulators as novel therapeutic approaches for hematological malignancies. | Leukemia 20010101 |
Flavopiridol induces apoptosis and caspase-3 activation of a newly characterized Burkitt's lymphoma cell line containing mutant p53 genes. | Blood cells, molecules & diseases 20010101 |
Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol. | Genome biology 20010101 |
Bcl-2 independence of flavopiridol-induced apoptosis. Mitochondrial depolarization in the absence of cytochrome c release. | The Journal of biological chemistry 20001013 |
Induction of growth inhibition and apoptosis in prostate cancer cells by flavopiridol. | International journal of oncology 20001001 |
Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia. | Blood 20000715 |
Flavopiridol induces cell cycle arrest and p53-independent apoptosis in non-small cell lung cancer cell lines. | Clinical cancer research : an official journal of the American Association for Cancer Research 19991001 |
Flavopiridol inhibits smooth muscle cell proliferation in vitro and neointimal formation In vivo after carotid injury in the rat. | Circulation 19990810 |
Sequential dependent enhancement of caspase activation and apoptosis by flavopiridol on paclitaxel-treated human gastric and breast cancer cells. | Clinical cancer research : an official journal of the American Association for Cancer Research 19990701 |
Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases. | Cancer research 19990601 |
Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53. | Blood 19981115 |
Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis. | The Journal of clinical investigation 19981101 |
Flavopiridol mediates cell cycle arrest and apoptosis in esophageal cancer cells. | Clinical cancer research : an official journal of the American Association for Cancer Research 19981101 |
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. | Science (New York, N.Y.) 19980724 |
Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity In vivo against human leukemia and lymphoma xenografts. | Blood 19980401 |
Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol. | Blood 19980115 |
Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells. | Cancer research 19960701 |
Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275. | Biochemical and biophysical research communications 19940615 |
Alteration of the phosphorylation state of p34cdc2 kinase by the flavone L86-8275 in breast carcinoma cells. Correlation with decreased H1 kinase activity. | Biochemical pharmacology 19931117 |
Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275. | Journal of the National Cancer Institute 19921118 |
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