200,000+ products from a single source!
sales@angenechem.com
131733-92-1 | Acetic acid, 2-(5,7,8,9-tetrahydro-5-hydroxy-6H-benzocyclohepten-6-ylidene)-, sodium salt (1:1)
CAS No: 131733-92-1 Catalog No: AG000ZMI MDL No:MFCD00270050
Product Description
Catalog Number:
AG000ZMI
Chemical Name:
Acetic acid, 2-(5,7,8,9-tetrahydro-5-hydroxy-6H-benzocyclohepten-6-ylidene)-, sodium salt (1:1)
CAS Number:
131733-92-1
Molecular Formula:
C13H13NaO3
Molecular Weight:
240.2303
MDL Number:
MFCD00270050
IUPAC Name:
sodium;(2E)-2-(5-hydroxy-5,7,8,9-tetrahydrobenzo[7]annulen-6-ylidene)acetate
InChI:
InChI=1S/C13H14O3.Na/c14-12(15)8-10-6-3-5-9-4-1-2-7-11(9)13(10)16;/h1-2,4,7-8,13,16H,3,5-6H2,(H,14,15);/q;+1/p-1/b10-8+;
InChI Key:
BTWDZCORIHHOPO-VRTOBVRTSA-M
SMILES:
[O-]C(=O)C=C1CCCc2c(C1O)cccc2.[Na+]
Properties
Complexity:
301
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
1
Exact Mass:
240.076g/mol
Formal Charge:
0
Heavy Atom Count:
17
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
240.234g/mol
Monoisotopic Mass:
240.076g/mol
Rotatable Bond Count:
1
Topological Polar Surface Area:
60.4A^2
Undefined Atom Stereocenter Count:
1
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Toxicologic/transport properties of NCS-382, a γ-hydroxybutyrate (GHB) receptor ligand, in neuronal and epithelial cells: Therapeutic implications for SSADH deficiency, a GABA metabolic disorder. | Toxicology in vitro : an international journal published in association with BIBRA 20180201 |
| In vitro toxicological evaluation of NCS-382, a high-affinity antagonist of γ-hydroxybutyrate (GHB) binding. | Toxicology in vitro : an international journal published in association with BIBRA 20170401 |
| Novel radioiodinated {gamma}-hydroxybutyric acid analogues for radiolabeling and Photolinking of high-affinity {gamma}-hydroxybutyric acid binding sites. | The Journal of pharmacology and experimental therapeutics 20101101 |
| Calcium and cAMP signaling induced by gamma-hydroxybutyrate receptor(s) stimulation in NCB-20 neurons. | Neuroscience 20100428 |
| Neurotoxic effects induced by gammahydroxybutyric acid (GHB) in male rats. | The international journal of neuropsychopharmacology 20091001 |
| Validation of high-affinity binding sites for succinic acid through distinguishable binding of gamma-hydroxybutyric acid receptor-specific NCS 382 antipodes. | Bioorganic & medicinal chemistry letters 20081201 |
| Characterization and pharmacology of the GHB receptor. | Annals of the New York Academy of Sciences 20081001 |
| Differentiating the discriminative stimulus effects of gamma-hydroxybutyrate and ethanol in a three-choice drug discrimination procedure in rats. | Pharmacology, biochemistry, and behavior 20080601 |
| Gamma-aminobutyric acidB (GABAB)-receptor mediation of different in vivo effects of gamma-butyrolactone. | Journal of pharmacological sciences 20080201 |
| [Effect of gamma-hydroxybutyric acid receptor on focal cerebral ischemia-reperfusion injury in rats]. | Yao xue xue bao = Acta pharmaceutica Sinica 20070801 |
| Metabolic GHB precursor succinate binds to gamma-hydroxybutyrate receptors: characterization of human basal ganglia areas nucleus accumbens and globus pallidus. | Journal of neuroscience research 20060701 |
| Succinate semialdehyde dehydrogenase deficiency does not down-regulate gamma-hydroxybutyric acid binding sites in the mouse brain. | Molecular genetics and metabolism 20060501 |
| Discriminative stimulus effects of flumazenil: perceptual masking by baclofen, and lack of substitution with gamma-hydroxybutyrate and its precursors 1,4-butanediol and gamma-butyrolactone. | Behavioural pharmacology 20060501 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Novel cyclic gamma-hydroxybutyrate (GHB) analogs with high affinity and stereoselectivity of binding to GHB sites in rat brain. | The Journal of pharmacology and experimental therapeutics 20051001 |
| Drosophila GABA(B) receptors are involved in behavioral effects of gamma-hydroxybutyric acid (GHB). | European journal of pharmacology 20050920 |
| Involvement of gamma-hydroxybutyrate (GHB) and GABA-B receptors in the acute behavioral effects of GHB in baboons. | Psychopharmacology 20050701 |
| Discriminative stimulus effects of gamma-hydroxybutyrate (GHB) in rats discriminating GHB from baclofen and diazepam. | The Journal of pharmacology and experimental therapeutics 20050701 |
| Resuscitative effect of a gamma-aminobutyric acid B receptor antagonist on gamma-hydroxybutyric acid mortality in mice. | Annals of emergency medicine 20050601 |
| Mechanisms underlying the sympathomimetic cardiovascular responses elicited by gamma-hydroxybutyrate. | Journal of cardiovascular pharmacology 20041201 |
| Ethanol does not alter the binding of the gamma-hydroxybutyric acid (GHB) receptor ligand [3H]NCS-382 in the rat brain. | Drug and alcohol dependence 20040906 |
| 4-Hydroxy-trans-2-nonenoic acid is a gamma-hydroxybutyrate receptor ligand in the cerebral cortex and hippocampus. | Journal of neurochemistry 20040601 |
| Gamma-hydroxybutyrate and ethanol depress spontaneous excitatory postsynaptic currents in dopaminergic neurons of the substantia nigra. | Brain research 20040130 |
| Effects of gamma-hydroxybutyrate (GHB) on schedule-controlled responding in rats: role of GHB and GABAB receptors. | The Journal of pharmacology and experimental therapeutics 20040101 |
| A review of pharmacology of NCS-382, a putative antagonist of gamma-hydroxybutyric acid (GHB) receptor. | CNS drug reviews 20040101 |
| Pathway-specific action of gamma-hydroxybutyric acid in sensory thalamus and its relevance to absence seizures. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20031210 |
| Selective gamma-hydroxybutyric acid receptor ligands increase extracellular glutamate in the hippocampus, but fail to activate G protein and to produce the sedative/hypnotic effect of gamma-hydroxybutyric acid. | Journal of neurochemistry 20031101 |
| Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice. | The European journal of neuroscience 20031101 |
| Quantitative autoradiographic analysis of the new radioligand [(3)H](2E)-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene) ethanoic acid ([(3)H]NCS-382) at gamma-hydroxybutyric acid (GHB) binding sites in rat brain. | Brain research 20030725 |
| Interactions of gamma-hydroxy butyrate with ethanol and NCS 382. | European journal of pharmacology 20030606 |
| A tertiary alcohol analog of gamma-hydroxybutyric acid as a specific gamma-hydroxybutyric acid receptor ligand. | The Journal of pharmacology and experimental therapeutics 20030501 |
| Therapeutic intervention in mice deficient for succinate semialdehyde dehydrogenase (gamma-hydroxybutyric aciduria). | The Journal of pharmacology and experimental therapeutics 20020701 |
| Stereoselectivity of NCS-382 binding to gamma-hydroxybutyrate receptor in the rat brain. | European journal of pharmacology 20020620 |
| GABA(B)-receptor mediation of the inhibitory effect of gamma-hydroxybutyric acid on intestinal motility in mice. | Life sciences 20020510 |
| Effects of the putative antagonist NCS382 on the behavioral pharmacological actions of gammahydroxybutyrate in mice. | Psychopharmacology 20020201 |
| Binding characteristics of the gamma-hydroxybutyric acid receptor antagonist [(3)H](2E)-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene) ethanoic acid in the rat brain. | The Journal of pharmacology and experimental therapeutics 20011201 |
| gamma-Hydroxybutyric acid and baclofen decrease extracellular acetylcholine levels in the hippocampus via GABA(B) receptors. | European journal of pharmacology 20011102 |
| Role of GABA(B) receptors in the sedative/hypnotic effect of gamma-hydroxybutyric acid. | European journal of pharmacology 20011012 |
| gamma-Hydroxybutyrate modulation of glutamate levels in the hippocampus: an in vivo and in vitro study. | Journal of neurochemistry 20010901 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.