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Home > Nitro Compounds > 131549-85-4
131549-85-4 | Benzenesulfonamide, N-(5-methyl-3-isoxazolyl)-4-nitroso-
CAS No: 131549-85-4 Catalog No: AG000ZEM MDL No:
Product Description
Catalog Number:
AG000ZEM
Chemical Name:
Benzenesulfonamide, N-(5-methyl-3-isoxazolyl)-4-nitroso-
CAS Number:
131549-85-4
Molecular Formula:
C10H9N3O4S
Molecular Weight:
267.2612
IUPAC Name:
N-(5-methyl-1,2-oxazol-3-yl)-4-nitrosobenzenesulfonamide
InChI:
InChI=1S/C10H9N3O4S/c1-7-6-10(12-17-7)13-18(15,16)9-4-2-8(11-14)3-5-9/h2-6H,1H3,(H,12,13)
InChI Key:
GHNQGDUYHCZZPT-UHFFFAOYSA-N
SMILES:
O=Nc1ccc(cc1)S(=O)(=O)Nc1noc(c1)C
Properties
Complexity:
386
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
267.031g/mol
Formal Charge:
0
Heavy Atom Count:
18
Hydrogen Bond Acceptor Count:
7
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
267.259g/mol
Monoisotopic Mass:
267.031g/mol
Rotatable Bond Count:
3
Topological Polar Surface Area:
110A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.9
Literature
| Title | Journal |
|---|---|
| Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells. | Toxicological sciences : an official journal of the Society of Toxicology 20170701 |
| Characterization of Peroxidases Expressed in Human Antigen Presenting Cells and Analysis of the Covalent Binding of Nitroso Sulfamethoxazole to Myeloperoxidase. | Chemical research in toxicology 20150120 |
| The development of in vitro culture methods to characterize primary T-cell responses to drugs. | Toxicological sciences : an official journal of the Society of Toxicology 20120501 |
| Covalent binding of nitroso-sulfonamides to glutathione S-transferase in guinea pigs with delayed type hypersensitivity. | International immunopharmacology 20120401 |
| Cutaneous drug hypersensitivity: immunological and genetic perspective. | Indian journal of dermatology 20110101 |
| Drug antigenicity, immunogenicity, and costimulatory signaling: evidence for formation of a functional antigen through immune cell metabolism. | Journal of immunology (Baltimore, Md. : 1950) 20101201 |
| Stimulation of human T cells with sulfonamides and sulfonamide metabolites. | The Journal of allergy and clinical immunology 20100201 |
| Covalent binding of the nitroso metabolite of sulfamethoxazole is important in induction of drug-specific T-cell responses in vivo. | Molecular pharmacology 20080601 |
| Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling. | Journal of immunology (Baltimore, Md. : 1950) 20070501 |
| Roles of endogenous ascorbate and glutathione in the cellular reduction and cytotoxicity of sulfamethoxazole-nitroso. | Toxicology 20060501 |
| Evaluation of the clinical, immunologic, and biochemical effects of nitroso sulfamethoxazole administration to dogs: a pilot study. | Toxicology 20050301 |
| Exposure of mice to the nitroso metabolite of sulfamethoxazole stimulates interleukin 5 production by CD4+ T-cells. | Toxicology 20050115 |
| Antigenicity and immunogenicity of sulphamethoxazole: demonstration of metabolism-dependent haptenation and T-cell proliferation in vivo. | British journal of pharmacology 20010501 |
| Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+ T-cells. | British journal of pharmacology 20010201 |
| Recognition of sulfamethoxazole and its reactive metabolites by drug-specific CD4+ T cells from allergic individuals. | Journal of immunology (Baltimore, Md. : 1950) 20000615 |
| Fine structural specificity differences of trimethoprim allergenic determinants. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 19961001 |
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