200,000+ products from a single source!
sales@angenechem.com
Home > Other Building Blocks > 1314883-11-8
1314883-11-8 | MMV-390048
CAS No: 1314883-11-8 Catalog No: AG01FKZ6 MDL No:
Product Description
Catalog Number:
AG01FKZ6
Chemical Name:
MMV-390048
CAS Number:
1314883-11-8
IUPAC Name:
5-(4-methylsulfonylphenyl)-3-[6-(trifluoromethyl)pyridin-3-yl]pyridin-2-amine
InChI:
InChI=1S/C18H14F3N3O2S/c1-27(25,26)14-5-2-11(3-6-14)13-8-15(17(22)24-10-13)12-4-7-16(23-9-12)18(19,20)21/h2-10H,1H3,(H2,22,24)
InChI Key:
RTJQABCNNLMCJF-UHFFFAOYSA-N
UNII:
0Z5T00JJ10
Properties
Complexity:
600
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
393.076g/mol
Formal Charge:
0
Heavy Atom Count:
27
Hydrogen Bond Acceptor Count:
8
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
393.384g/mol
Monoisotopic Mass:
393.076g/mol
Rotatable Bond Count:
3
Topological Polar Surface Area:
94.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.8
Literature
| Title | Journal |
|---|---|
| Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. | Science translational medicine 20170426 |
| Quinoline-pyrimidine hybrids: synthesis, antiplasmodial activity, SAR, and mode of action studies. | Journal of medicinal chemistry 20140123 |
| Cell-based medicinal chemistry optimization of high throughput screening hits for orally active antimalarials. Part 2: hits from SoftFocus kinase and other libraries. | Journal of medicinal chemistry 20131024 |
| Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies. | European journal of medicinal chemistry 20130801 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.