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130853-76-8 | 2(5H)-Furanone, 5-methyl-3-[(2S,8S,13R)-2,8,13-trihydroxy-13-[(2R,5R)-tetrahydro-5-[(1S)-1-hydroxytridecyl]-2-furanyl]tridecyl]-, (5S)-
CAS No: 130853-76-8 Catalog No: AG000V11 MDL No:
Product Description
Catalog Number:
AG000V11
Chemical Name:
2(5H)-Furanone, 5-methyl-3-[(2S,8S,13R)-2,8,13-trihydroxy-13-[(2R,5R)-tetrahydro-5-[(1S)-1-hydroxytridecyl]-2-furanyl]tridecyl]-, (5S)-
CAS Number:
130853-76-8
Molecular Formula:
C35H64O7
Molecular Weight:
596.8785
IUPAC Name:
2-methyl-4-[2,8,13-trihydroxy-13-[5-(1-hydroxytridecyl)oxolan-2-yl]tridecyl]-2H-furan-5-one
InChI:
InChI=1S/C35H64O7/c1-3-4-5-6-7-8-9-10-11-15-21-31(38)33-23-24-34(42-33)32(39)22-17-16-19-29(36)18-13-12-14-20-30(37)26-28-25-27(2)41-35(28)40/h25,27,29-34,36-39H,3-24,26H2,1-2H3
InChI Key:
XNODZYPOIPVPRF-UHFFFAOYSA-N
SMILES:
CCCCCCCCCCCC[C@@H]([C@H]1CC[C@@H](O1)[C@@H](CCCC[C@H](CCCCC[C@@H](CC1=C[C@@H](OC1=O)C)O)O)O)O
Properties
Complexity:
726
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
596.465g/mol
Formal Charge:
0
Heavy Atom Count:
42
Hydrogen Bond Acceptor Count:
7
Hydrogen Bond Donor Count:
4
Isotope Atom Count:
0
Molecular Weight:
596.89g/mol
Monoisotopic Mass:
596.465g/mol
Rotatable Bond Count:
26
Topological Polar Surface Area:
116A^2
Undefined Atom Stereocenter Count:
7
Undefined Bond Stereocenter Count:
0
XLogP3:
8.4
Literature
| Title | Journal |
|---|---|
| Annonacin in Asimina triloba fruit: implication for neurotoxicity. | Neurotoxicology 20120101 |
| In situ absorption in rat intestinal tract of solid dispersion of annonaceous acetogenins. | Gastroenterology research and practice 20120101 |
| Natural toxins implicated in the development of Parkinson's disease. | Therapeutic advances in neurological disorders 20111101 |
| Annonacin induces cell cycle-dependent growth arrest and apoptosis in estrogen receptor-α-related pathways in MCF-7 cells. | Journal of ethnopharmacology 20111011 |
| Is neurodegenerative disease a long-latency response to early-life genotoxin exposure? | International journal of environmental research and public health 20111001 |
| Yeast as a model system to study tau biology. | International journal of Alzheimer's disease 20110101 |
| Nigerian foodstuffs with prostate cancer chemopreventive polyphenols. | Infectious agents and cancer 20110101 |
| Complex I: inhibitors, inhibition and neurodegeneration. | Experimental neurology 20100801 |
| Convergence of amyloid-beta and tau pathologies on mitochondria in vivo. | Molecular neurobiology 20100601 |
| The alternative medicine pawpaw and its acetogenin constituents suppress tumor angiogenesis via the HIF-1/VEGF pathway. | Journal of natural products 20100528 |
| Synthesis of annonacin isolated from Annona densicoma. | Bioscience, biotechnology, and biochemistry 20100101 |
| Antinociceptive and anti-inflammatory activities of the ethanol extract of Annona muricata L. leaves in animal models. | International journal of molecular sciences 20100101 |
| Disruption of mitochondrial DNA replication in Drosophila increases mitochondrial fast axonal transport in vivo. | PloS one 20090101 |
| Atypical parkinsonism in the Caribbean island of Guadeloupe: etiological role of the mitochondrial complex I inhibitor annonacin. | Movement disorders : official journal of the Movement Disorder Society 20081115 |
| Goniothalamus species: a source of drugs for the treatment of cancers and bacterial infections? | Evidence-based complementary and alternative medicine : eCAM 20070901 |
| Annonacin, a natural mitochondrial complex I inhibitor, causes tau pathology in cultured neurons. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20070718 |
| Atypical parkinsonism in Guadeloupe: a common risk factor for two closely related phenotypes? | Brain : a journal of neurology 20070301 |
| Acetogenins in Annona muricata L. (annonaceae) leaves are potent molluscicides. | Natural product research 20060301 |
| Is atypical parkinsonism in the Caribbean caused by the consumption of Annonacae? | Journal of neural transmission. Supplementum 20060101 |
| Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe. | Movement disorders : official journal of the Movement Disorder Society 20051201 |
| Montacin and cis-montacin, two new cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona montana. | Journal of natural products 20041101 |
| Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in Guadeloupe. | Journal of neurochemistry 20040101 |
| Inhibitory effects on mitochondrial complex I of semisynthetic mono-tetrahydrofuran acetogenin derivatives. | Bioorganic & medicinal chemistry letters 20031117 |
| Annonacin, a mono-tetrahydrofuran acetogenin, arrests cancer cells at the G1 phase and causes cytotoxicity in a Bax- and caspase-3-related pathway. | Life sciences 20030509 |
| The mitochondrial complex I inhibitor annonacin is toxic to mesencephalic dopaminergic neurons by impairment of energy metabolism. | Neuroscience 20030101 |
| In vitro antitumor structure-activity relationships of threo/trans/threo mono-tetrahydrofuranic acetogenins: correlations with their inhibition of mitochondrial complex I. | Oncology research 20030101 |
| New cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona muricata. | Journal of natural products 20020401 |
| Selective action of acetogenin mitochondrial complex I inhibitors. | Zeitschrift fur Naturforschung. C, Journal of biosciences 20020101 |
| Cytotoxic mono-tetrahydrofuran ring acetogenins from leaves of Annona montana. | Planta medica 20011201 |
| Annomocherin, annonacin and annomontacin: a novel and two known bioactive mono-tetrahydrofuran annonaceous acetogenins from Annona cherimolia seeds. | Archives of pharmacal research 20010801 |
| Enantioselective syntheses of monotetrahydrofuran Annonaceous acetogenins tonkinecin and annonacin starting from carbohydrates. | The Journal of organic chemistry 20010209 |
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