200,000+ products from a single source!
sales@angenechem.com
Home > Other Building Blocks > 13073-35-3
13073-35-3 | L-Homocysteine, S-ethyl-
CAS No: 13073-35-3 Catalog No: AG000UWC MDL No:MFCD00002626
Product Description
Catalog Number:
AG000UWC
Chemical Name:
L-Homocysteine, S-ethyl-
CAS Number:
13073-35-3
Molecular Formula:
C6H13NO2S
Molecular Weight:
163.2379
MDL Number:
MFCD00002626
IUPAC Name:
(2S)-2-amino-4-ethylsulfanylbutanoic acid
InChI:
InChI=1S/C6H13NO2S/c1-2-10-4-3-5(7)6(8)9/h5H,2-4,7H2,1H3,(H,8,9)/t5-/m0/s1
InChI Key:
GGLZPLKKBSSKCX-YFKPBYRVSA-N
SMILES:
CCSCC[C@@H](C(=O)O)N
EC Number:
235-966-4
UNII:
WX1BN24WZT
Properties
Complexity:
108
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
1
Defined Bond Stereocenter Count:
0
Exact Mass:
163.067g/mol
Formal Charge:
0
Heavy Atom Count:
10
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
163.235g/mol
Monoisotopic Mass:
163.067g/mol
Rotatable Bond Count:
5
Topological Polar Surface Area:
88.6A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-1.5
Literature
| Title | Journal |
|---|---|
| Discriminating between adaptive and carcinogenic liver hypertrophy in rat studies using logistic ridge regression analysis of toxicogenomic data: The mode of action and predictive models. | Toxicology and applied pharmacology 20170301 |
| Genomic models of short-term exposure accurately predict long-term chemical carcinogenicity and identify putative mechanisms of action. | PloS one 20140101 |
| Bmi1 is required for regeneration of the exocrine pancreas in mice. | Gastroenterology 20120901 |
| Small-molecule inhibitors of the protein methyltransferase SET7/9 identified in a high-throughput screen. | Journal of biomolecular screening 20120901 |
| The inhibitory effect of rapamycin on the oval cell response and development of preneoplastic foci in the rat. | Experimental and molecular pathology 20120801 |
| Prevention effects of ND-07, a novel drug candidate with a potent antioxidative action and anti-inflammatory action, in animal models of severe acute pancreatitis. | European journal of pharmacology 20120715 |
| Identification and characterization of genes related to the production of organic acids in yeast. | Journal of bioscience and bioengineering 20120501 |
| Role of bone marrow cells in the development of pancreatic fibrosis in a rat model of pancreatitis induced by a choline-deficient/ethionine-supplemented diet. | Biochemical and biophysical research communications 20120420 |
| Automated annotation and quantification of metabolites in 1H NMR data of biological origin. | Analytical and bioanalytical chemistry 20120401 |
| Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. | Nature medicine 20120304 |
| Importance of methionine metabolism in morula-to-blastocyst transition in bovine preimplantation embryos. | The Journal of reproduction and development 20120101 |
| Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). | PLoS computational biology 20111201 |
| Kupffer cells influence parenchymal invasion and phenotypic orientation, but not the proliferation, of liver progenitor cells in a murine model of liver injury. | The American journal of pathology 20111001 |
| Fatty liver is associated with impaired activity of PPARγ-coactivator 1α (PGC1α) and mitochondrial biogenesis in mice. | Laboratory investigation; a journal of technical methods and pathology 20110701 |
| Gas6 deficiency prevents liver inflammation, steatohepatitis, and fibrosis in mice. | American journal of physiology. Gastrointestinal and liver physiology 20110601 |
| Remodelling of extracellular matrix is a requirement for the hepatic progenitor cell response. | Gut 20110401 |
| New short term prediction method for chemical carcinogenicity by hepatic transcript profiling following 28-day toxicity tests in rats. | Cancer informatics 20110101 |
| A predictive ligand-based Bayesian model for human drug-induced liver injury. | Drug metabolism and disposition: the biological fate of chemicals 20101201 |
| Age dependence of oval cell responses and bile duct carcinomas in male fischer 344 rats fed a cyclic choline-deficient, ethionine-supplemented diet. | Hepatology (Baltimore, Md.) 20101101 |
| Impaired liver glucose production in a murine model of steatosis and endotoxemia: protection by inducible nitric oxide synthase. | Antioxidants & redox signaling 20100701 |
| Effects of acute ethionine injection on plasma ghrelin and obestatin levels in trained male rats. | Metabolism: clinical and experimental 20100701 |
| Tumor necrosis factor-like weak inducer of apoptosis is a mitogen for liver progenitor cells. | Hepatology (Baltimore, Md.) 20100701 |
| Imprinting: RNA expression for homocysteine recycling in the human oocyte. | Fertility and sterility 20100315 |
| Time-resolved biomarker discovery in 1H-NMR data using generalized fuzzy Hough transform alignment and parallel factor analysis. | Analytical and bioanalytical chemistry 20100301 |
| A medium-term, rapid rat bioassay model for the detection of carcinogenic potential of chemicals. | Toxicologic pathology 20100101 |
| Chronic pancreatitis in mice by treatment with choline-deficient ethionine-supplemented diet. | Experimental animals 20100101 |
| An evaluation of the chick cardiomyocyte micromass system for identification of teratogens in a blind trial. | Reproductive toxicology (Elmsford, N.Y.) 20091201 |
| Identification of genomic biomarkers for concurrent diagnosis of drug-induced renal tubular injury using a large-scale toxicogenomics database. | Toxicology 20091109 |
| Superoxide dismutase activity as a measure of hepatic oxidative stress in cattle following ethionine administration. | Veterinary journal (London, England : 1997) 20091101 |
| Ethionine-induced ATP depletion represses mTOR signaling in the absence of increases in AMP-activated protein kinase activity in the rat liver. | Bioscience, biotechnology, and biochemistry 20090901 |
| Gene expression profiling in rat liver treated with various hepatotoxic-compounds inducing coagulopathy. | The Journal of toxicological sciences 20090601 |
| Separation and determination of seleno amino acids using gas chromatography hyphenated with inductively coupled plasma mass spectrometry after hollow fiber liquid phase microextraction. | Journal of mass spectrometry : JMS 20090501 |
| Relation between liver progenitor cell expansion and extracellular matrix deposition in a CDE-induced murine model of chronic liver injury. | Hepatology (Baltimore, Md.) 20090501 |
| Expression of extracellular matrix genes in cultured hepatic oval cells: an origin of hepatic stellate cells through transforming growth factor beta? | Liver international : official journal of the International Association for the Study of the Liver 20090401 |
| Risperidone attenuates local and systemic inflammatory responses to ameliorate diet-induced severe necrotic pancreatitis in mice: it may provide a new therapy for acute pancreatitis. | The Journal of pharmacology and experimental therapeutics 20090101 |
| Lymphotoxin-beta receptor signaling regulates hepatic stellate cell function and wound healing in a murine model of chronic liver injury. | Hepatology (Baltimore, Md.) 20090101 |
| Ginger extract (Zingiber officinale) has anti-cancer and anti-inflammatory effects on ethionine-induced hepatoma rats. | Clinics (Sao Paulo, Brazil) 20081201 |
| C-kit inhibition by imatinib mesylate attenuates progenitor cell expansion and inhibits liver tumor formation in mice. | Gastroenterology 20080901 |
| Bone marrow cells play only a very minor role in chronic liver regeneration induced by a choline-deficient, ethionine-supplemented diet. | Stem cell research 20080901 |
| Total glutathione and glutathione reductase in bovine erythrocytes and liver biopsy. | The Journal of veterinary medical science 20080801 |
| X-ray structure of the [FeFe]-hydrogenase maturase HydE from Thermotoga maritima. | The Journal of biological chemistry 20080704 |
| Random mutagenesis and recombination of sam1 gene by integrating error-prone PCR with staggered extension process. | Biotechnology letters 20080701 |
| Bone marrow-derived cells fuse with hepatic oval cells but are not involved in hepatic tumorigenesis in the choline-deficient ethionine-supplemented diet rat model. | Carcinogenesis 20080201 |
| Misincorporation of amino acid analogues into proteins by biosynthesis. | The international journal of biochemistry & cell biology 20080101 |
| Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in mice. | Laboratory investigation; a journal of technical methods and pathology 20071201 |
| Analysis of time-related metabolic fluctuations induced by ethionine in the rat. | Journal of proteome research 20071201 |
| The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe. | The Journal of biological chemistry 20070824 |
| Therapeutic treatment with poly(ADP-ribose) polymerase inhibitors attenuates the severity of acute pancreatitis and associated liver and lung injury. | British journal of pharmacology 20070801 |
| 6His-Eco29kI methyltransferase methylation site and kinetic mechanism characterization. | Biochimica et biophysica acta 20070801 |
| Characteristics of methionine production by an engineered Corynebacterium glutamicum strain. | Metabolic engineering 20070701 |
| Silencing MAT2A gene by RNA interference inhibited cell growth and induced apoptosis in human hepatoma cells. | Hepatology research : the official journal of the Japan Society of Hepatology 20070501 |
| Hepatotoxin-induced hypertyrosinemia and its toxicological significance. | Archives of toxicology 20070301 |
| Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway. | Plant & cell physiology 20070201 |
| Different effects of sulfur amino acids on prolidase and prolinase activity in normal and prolidase-deficient human erythrocytes. | Clinica chimica acta; international journal of clinical chemistry 20070101 |
| Attenuated liver progenitor (oval) cell and fibrogenic responses to the choline deficient, ethionine supplemented diet in the BALB/c inbred strain of mice. | Journal of hepatology 20070101 |
| Isolation, culture and immortalisation of hepatic oval cells from adult mice fed a choline-deficient, ethionine-supplemented diet. | The international journal of biochemistry & cell biology 20070101 |
| An unusual S-adenosylmethionine synthetase gene from dinoflagellate is methylated. | BMC molecular biology 20070101 |
| Activation of nuclear factor kappa B and severe hepatic necrosis may mediate systemic inflammation in choline-deficient/ethionine-supplemented diet-induced pancreatitis. | Pancreas 20061001 |
| Hepatic oval cell response to the choline-deficient, ethionine supplemented model of murine liver injury is attenuated by the administration of a cyclo-oxygenase 2 inhibitor. | Carcinogenesis 20060801 |
| Integrity of the methylation cycle is essential for mammalian neural tube closure. | Birth defects research. Part A, Clinical and molecular teratology 20060701 |
| Natural and directed biosynthesis of communesin alkaloids. | Phytochemistry 20060301 |
| Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. | Bioorganic & medicinal chemistry letters 20060301 |
| Effect of amino acids containing sulfur on dithiolopyrrolone antibiotic productions by Saccharothrix algeriensis NRRL B-24137. | Journal of applied microbiology 20060201 |
| S-adenosyl methionine: A connection between nutritional and genetic risk factors for neurodegeneration in Alzheimer's disease. | The journal of nutrition, health & aging 20060101 |
| Harnessing natural diversity to probe metabolic pathways. | PLoS genetics 20051201 |
| Effects of R-102444 and its active metabolite R-96544, selective 5-HT2A receptor antagonists, on experimental acute and chronic pancreatitis: Additional evidence for possible involvement of 5-HT2A receptors in the development of experimental pancreatitis. | European journal of pharmacology 20051003 |
| Inhibition of adult liver progenitor (oval) cell growth and viability by an agonist of the peroxisome proliferator activated receptor (PPAR) family member gamma, but not alpha or delta. | Carcinogenesis 20051001 |
| Regional differences in gastrointestinal motility disturbances during acute necrotising pancreatitis. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20051001 |
| Single-gene knockout of a novel regulatory element confers ethionine resistance and elevates methionine production in Corynebacterium glutamicum. | Applied microbiology and biotechnology 20050801 |
| Liver inflammation and cytokine production, but not acute phase protein synthesis, accompany the adult liver progenitor (oval) cell response to chronic liver injury. | Immunology and cell biology 20050801 |
| Natural disruption of group 2 phospholipase A2 gene protects against choline-deficient ethionine-supplemented diet-induced acute pancreatitis and lung injury. | Pancreas 20050701 |
| Oncostatin M induces an acute phase response but does not modulate the growth or maturation-status of liver progenitor (oval) cells in culture. | Experimental cell research 20050515 |
| Differential lymphotoxin-beta and interferon gamma signaling during mouse liver regeneration induced by chronic and acute injury. | Hepatology (Baltimore, Md.) 20050201 |
| TNF/LTalpha double knockout mice display abnormal inflammatory and regenerative responses to acute and chronic liver injury. | Cell and tissue research 20050101 |
| In vivo antihepatotoxic effects of Ligularia fischeri var. spiciformis and the identification of the active component, 3,4-dicaffeoylquinic acid. | Journal of medicinal food 20050101 |
| Selection and characterization of L-ethionine resistant mutants of Trichosporon cutaneum. | Zeitschrift fur Naturforschung. C, Journal of biosciences 20050101 |
| Ablation of phosphoinositide 3-kinase-gamma reduces the severity of acute pancreatitis. | The American journal of pathology 20041201 |
| [Animal experimental models for acute pancreatitis]. | Nihon rinsho. Japanese journal of clinical medicine 20041101 |
| Decreases in serum apolipoprotein C-III concentration in cows with ethionine-induced fatty liver. | The Journal of veterinary medical science 20040901 |
| Suppression of 8-oxo-2'-deoxyguanosine formation and carcinogenesis induced by N-nitrosobis (2-oxopropyl)amine in hamsters by esculetin and esculin. | Free radical research 20040801 |
| Protective effect of soybean against hepatocarcinogenesis induced by DL-ethionine. | Journal of biochemistry and molecular biology 20040531 |
| Gene expression profiles in liver regeneration with oval cell induction. | Biochemical and biophysical research communications 20040430 |
| Activation, isolation, identification and in vitro proliferation of oval cells from adult rat livers. | Cell proliferation 20040401 |
| Organ-specific stress induces mouse pancreatic keratin overexpression in association with NF-kappaB activation. | Journal of cell science 20040401 |
| Direct effects of interleukin-6 on liver progenitor oval cells in culture. | Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20040101 |
| Enhancement of the primary flavor compound methional in potato by increasing the level of soluble methionine. | Journal of agricultural and food chemistry 20030910 |
| Cellular proliferation in the canine pancreas after d,l-ethionine dosage as detected by double immunohistochemical labelling. | Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20030901 |
| S-adenosylmethionine (AdoMet) modulates endotoxin stimulated interleukin-10 production in monocytes. | American journal of physiology. Gastrointestinal and liver physiology 20030601 |
| Physiologically relevant metal cofactor for methionine aminopeptidase-2 is manganese. | Biochemistry 20030506 |
| An hypothesis for a mechanism underlying hepatotoxin-induced hypercreatinuria. | Archives of toxicology 20030401 |
| Macrophage migration inhibitory factor is a critical mediator of severe acute pancreatitis. | Gastroenterology 20030301 |
| Diminished lung injury with vascular adhesion molecule-1 blockade in choline-deficient ethionine diet-induced pancreatitis. | Surgery 20030201 |
| Pancreatic concentrations of cefepime in experimental necrotizing pancreatitis. | Journal of chemotherapy (Florence, Italy) 20030201 |
| Role of S-adenosylmethionine in two experimental models of pancreatitis. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030101 |
| Effect of IS-741 on ethionine-induced acute pancreatitis in rats: relation to pancreatic acinar cell regeneration. | Journal of gastroenterology 20030101 |
| Pancreatic regeneration after ethionine-induced acute pancreatitis in rats lacking pancreatic CCK-A receptor gene expression. | Journal of gastroenterology 20030101 |
| Translational initiation regulators are hypophosphorylated in rat liver during ethionine-mediated ATP depletion. | Biochemical and biophysical research communications 20021025 |
| Ethanol interactions with a choline-deficient, ethionine-supplemented feeding regime potentiate pre-neoplastic cellular alterations in rat liver. | Carcinogenesis 20021001 |
| Identification of a short highly conserved amino acid sequence as the functional region required for posttranscriptional autoregulation of the cystathionine gamma-synthase gene in Arabidopsis. | The Journal of biological chemistry 20020927 |
| Isolation, cloning and expression of a multifunctional O-methyltransferase capable of forming 2,5-dimethyl-4-methoxy-3(2H)-furanone, one of the key aroma compounds in strawberry fruits. | The Plant journal : for cell and molecular biology 20020901 |
| Effect of d,l-ethionine administration on the histomorphology of canine pancreatic acinar and beta-cells. | Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20020801 |
| A single-nucleotide mutation in a gene encoding S-adenosylmethionine synthetase is associated with methionine over-accumulation phenotype in Arabidopsis thaliana. | Genes & genetic systems 20020401 |
| Generation and characterization of p53 null transformed hepatic progenitor cells: oval cells give rise to hepatocellular carcinoma. | Carcinogenesis 20020301 |
| Protein repair methyltransferase from the hyperthermophilic archaeon Pyrococcus furiosus. Unusual methyl-accepting affinity for D-aspartyl and N-succinyl-containing peptides. | The Journal of biological chemistry 20020111 |
| Constitutive overexpression of cystathionine gamma-synthase in Arabidopsis leads to accumulation of soluble methionine and S-methylmethionine. | Plant physiology 20020101 |
| Evaluation of d,l-ethionine as a mechanism for pancreatic islet regeneration in dogs. | Australian veterinary journal 20020101 |
| Methionine depletion induces transcription of the mRNA (N6-adenosine)methyltransferase. | The international journal of biochemistry & cell biology 20011101 |
| Methylation is involved in the Ustilago maydis mating response. | Fungal genetics and biology : FG & B 20011001 |
| A modified choline-deficient, ethionine-supplemented diet protocol effectively induces oval cells in mouse liver. | Hepatology (Baltimore, Md.) 20010901 |
| Adenoviral delivery of human and viral IL-10 in murine sepsis. | Journal of immunology (Baltimore, Md. : 1950) 20010715 |
| Biosynthesis of diaporthin and orthosporin by Aspergillus ochraceus. | Phytochemistry 20010501 |
| Evaluation of lysine and methionine production in some Lactobacilli and yeasts from ogi. | International journal of food microbiology 20010122 |
| Methionine deprivation and methionine analogs inhibit cell proliferation and growth of human xenografted gliomas. | Life sciences 19970101 |
| 13-cis-retinoic acid and hepatic steatosis in rats. | Biochemical pharmacology 19930720 |
| Effects of the seleno-organic substance Ebselen in two different models of acute pancreatitis. | Pancreas 19910501 |
| Correlation between medium-term liver bioassay system data and results of long-term testing in rats. | Carcinogenesis 19900401 |
| Hepatic levels of cytosolic, microsomal and 'mitochondrial' epoxide hydrolases and other drug-metabolizing enzymes after treatment of mice with various xenobiotics and endogenous compounds. | Chemico-biological interactions 19870101 |
| Comparison of the promoting effects of various agents in induction of preneoplastic lesions in rat liver. | Environmental health perspectives 19830401 |
| Increased alpha1-fetoprotein production in rat liver injuries induced by various hepatotoxins. | Gan 19760401 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.