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130663-39-7 | 1H-Imidazo[4,5-c]pyridine-6-carboxylic acid, 1-[[4-(dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-, (6S)-
CAS No: 130663-39-7 Catalog No: AG000US2 MDL No:MFCD00896427
Product Description
Catalog Number:
AG000US2
Chemical Name:
1H-Imidazo[4,5-c]pyridine-6-carboxylic acid, 1-[[4-(dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-, (6S)-
CAS Number:
130663-39-7
Molecular Formula:
C31H32N4O3
Molecular Weight:
508.6108
MDL Number:
MFCD00896427
IUPAC Name:
(6S)-1-[[4-(dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-6,7-dihydro-4H-imidazo[4,5-c]pyridine-6-carboxylic acid
InChI:
InChI=1S/C31H32N4O3/c1-21-16-22(14-15-26(21)33(2)3)18-34-20-32-25-19-35(28(31(37)38)17-27(25)34)30(36)29(23-10-6-4-7-11-23)24-12-8-5-9-13-24/h4-16,20,28-29H,17-19H2,1-3H3,(H,37,38)/t28-/m0/s1
InChI Key:
YSTVFDAKLDMYCR-NDEPHWFRSA-N
SMILES:
OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C
Properties
Complexity:
791
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
1
Defined Bond Stereocenter Count:
0
Exact Mass:
508.247g/mol
Formal Charge:
0
Heavy Atom Count:
38
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
508.622g/mol
Monoisotopic Mass:
508.247g/mol
Rotatable Bond Count:
7
Topological Polar Surface Area:
78.7A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.4
Literature
| Title | Journal |
|---|---|
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| International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. | Pharmacological reviews 20130701 |
| Discovery and characterization of alamandine: a novel component of the renin-angiotensin system. | Circulation research 20130412 |
| Similarities and differences between effects of angiotensin III and angiotensin II on human prostate cancer cell migration and proliferation. | Peptides 20121001 |
| Cardiovascular actions of angiotensin-(1-12) in the hypothalamic paraventricular nucleus of the rat are mediated via angiotensin II. | Experimental physiology 20120901 |
| Perinatal nicotine exposure increases vulnerability of hypoxic-ischemic brain injury in neonatal rats: role of angiotensin II receptors. | Stroke 20120901 |
| Angiotensin II type 2 receptor-mediated inhibition of NaCl absorption is blunted in thick ascending limbs from Dahl salt-sensitive rats. | Hypertension (Dallas, Tex. : 1979) 20120901 |
| Compound 21 induces vasorelaxation via an endothelium- and angiotensin II type 2 receptor-independent mechanism. | Hypertension (Dallas, Tex. : 1979) 20120901 |
| Counteraction between angiotensin II and angiotensin-(1-7) via activating angiotensin type I and Mas receptor on rat renal mesangial cells. | Regulatory peptides 20120820 |
| Resveratrol attenuates angiotensin II-induced senescence of vascular smooth muscle cells. | Regulatory peptides 20120820 |
| Angiotensin-(3-4) counteracts the Angiotensin II inhibitory action on renal Ca2+-ATPase through a cAMP/PKA pathway. | Regulatory peptides 20120820 |
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| Intrarenal angiotensin III is the predominant agonist for proximal tubule angiotensin type 2 receptors. | Hypertension (Dallas, Tex. : 1979) 20120801 |
| Implication of multiple signaling pathways in the regulation of angiotensin II induced enhanced expression of Giα proteins in vascular smooth muscle cells. | Canadian journal of physiology and pharmacology 20120801 |
| Role of central angiotensin receptors in scopolamine-induced impairment in memory, cerebral blood flow, and cholinergic function. | Psychopharmacology 20120701 |
| AT2 receptor non-peptide agonist C21 promotes natriuresis in obese Zucker rats. | Hypertension research : official journal of the Japanese Society of Hypertension 20120601 |
| Angiotensin II induces tumor necrosis factor-α expression and release from cultured human podocytes. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120401 |
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| The roles of angiotensin II receptors in the portosystemic collaterals of portal hypertensive and cirrhotic rats. | Journal of vascular research 20120101 |
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| Angiotensin II type 1 receptor, but no type 2 receptor, interferes with the insulin-induced nitric oxide production in HUVECs. | Atherosclerosis 20111201 |
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| Angiotensin III stimulates ERK1/2 mitogen-activated protein kinases and astrocyte growth in cultured rat astrocytes. | Neuropeptides 20111001 |
| Regulation of angiotensinogen by angiotensin II in mouse primary astrocyte cultures. | Journal of neurochemistry 20111001 |
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| Both AT₁ and AT₂ receptors mediate proliferation and migration of porcine vascular smooth muscle cells. | American journal of physiology. Heart and circulatory physiology 20110901 |
| Activation of central angiotensin type 2 receptors suppresses norepinephrine excretion and blood pressure in conscious rats. | American journal of hypertension 20110601 |
| 20-Hydroxyeicosatetraenoic acid synthesis is increased in human neutrophils and platelets by angiotensin II and endothelin-1. | American journal of physiology. Heart and circulatory physiology 20110401 |
| A single beta-amino acid substitution to angiotensin II confers AT2 receptor selectivity and vascular function. | Hypertension (Dallas, Tex. : 1979) 20110301 |
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| Angiotensin II/angiotensin II type I receptor (AT1R) signaling promotes MCF-7 breast cancer cells survival via PI3-kinase/Akt pathway. | Journal of cellular physiology 20101001 |
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| Angiotensin II enhances connecting tubule glomerular feedback. | Hypertension (Dallas, Tex. : 1979) 20101001 |
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| The renin-angiotensin system mediates hyperoxia-induced collagen production in human lung fibroblasts. | Free radical biology & medicine 20100701 |
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| Effects of angiotensin metabolites in the coronary vascular bed of the spontaneously hypertensive rat: loss of angiotensin II type 2 receptor-mediated vasodilation. | Hypertension (Dallas, Tex. : 1979) 20100201 |
| Stimulation of angiotensin AT2 receptors by the non-peptide agonist, Compound 21, evokes vasodepressor effects in conscious spontaneously hypertensive rats. | British journal of pharmacology 20100201 |
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| Angiotensin-(1-7) inhibits in vitro endothelial cell tube formation in human umbilical vein endothelial cells through the AT(1-7) receptor. | Endocrine 20071001 |
| Angiotensin II type 2 receptor vasoactivity in internal mammary arteries of patients with coronary artery disease. | Journal of cardiovascular pharmacology 20071001 |
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| Suppression of diabetes-induced retinal inflammation by blocking the angiotensin II type 1 receptor or its downstream nuclear factor-kappaB pathway. | Investigative ophthalmology & visual science 20070901 |
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| On the mechanism of coronary vasodilation induced by angiotensin-(1-7) in the isolated guinea pig heart. | Basic & clinical pharmacology & toxicology 20070601 |
| Angiotensin II-induced genomic damage in renal cells can be prevented by angiotensin II type 1 receptor blockage or radical scavenging. | American journal of physiology. Renal physiology 20070501 |
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| Identification of a novel non-AT1, non-AT2 angiotensin binding site in the rat brain. | Brain research 20070427 |
| Angiotensin II type 2 receptor decreases ischemia reperfusion induced fluid leak. | The Journal of surgical research 20070401 |
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| Translocation of AT1- and AT2-receptors by higher concentrations of angiotensin II in the smooth muscle cells of rat internal anal sphincter. | The Journal of pharmacology and experimental therapeutics 20061201 |
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| Angiotensin II type 2 receptor expression after vascular injury: differing effects of angiotensin-converting enzyme inhibition and angiotensin receptor blockade. | Hypertension (Dallas, Tex. : 1979) 20061101 |
| Angiotensin II regulates migration in mouse cultured mesangial cells: evidence for the presence of receptor subtype-specific regulation. | The Journal of endocrinology 20061101 |
| Increased renal vascular reactivity to ANG II after unilateral nephrectomy in the rat involves 20-HETE. | American journal of physiology. Regulatory, integrative and comparative physiology 20061001 |
| Ang II and Ang III modulate PTZ seizure threshold in non-stressed and stressed mice: possible involvement of noradrenergic mechanism. | Neuropeptides 20061001 |
| Biphasic actions of angiotensin IV on renal blood flow in the rat. | Regulatory peptides 20060911 |
| Effects of i.c.v. losartan on the angiotensin II-mediated vasopressin release and hypothalamic fos expression in near-term ovine fetuses. | Peptides 20060901 |
| Angiotensin type 1 and type 2 receptor blockade in chronic allograft nephropathy. | Kidney international 20060901 |
| Angiotensin II induced contraction of rat and human small intestinal wall musculature in vitro. | Acta physiologica (Oxford, England) 20060901 |
| AT1 receptor-mediated accumulation of extracellular angiotensin II in proximal tubule cells: role of cytoskeleton microtubules and tyrosine phosphatases. | American journal of physiology. Renal physiology 20060801 |
| Angiotensin II disrupts inhibitory avoidance memory retrieval. | Hormones and behavior 20060801 |
| Bradykinin B2 receptor knockout mice are protected from thrombosis by increased nitric oxide and prostacyclin. | Blood 20060701 |
| Angiotensin II type-2 receptor stimulation prevents neural damage by transcriptional activation of methyl methanesulfonate sensitive 2. | Hypertension (Dallas, Tex. : 1979) 20060701 |
| Angiotensin II type 2 receptor agonist directly inhibits proximal tubule sodium pump activity in obese but not in lean Zucker rats. | Hypertension (Dallas, Tex. : 1979) 20060601 |
| AT2 receptor-mediated vasodilation in the mouse heart depends on AT1A receptor activation. | British journal of pharmacology 20060601 |
| Dual mechanisms of angiotensin-induced activation of mouse sympathetic neurones. | The Journal of physiology 20060515 |
| The AT1A receptor 'gain-of-function' mutant N111S/delta329 is both constitutively active and hyperreactive to angiotensin II. | American journal of physiology. Endocrinology and metabolism 20060501 |
| Angiotensin II infusion decreases plasma adiponectin level via its type 1 receptor in rats: an implication for hypertension-related insulin resistance. | Metabolism: clinical and experimental 20060401 |
| Renal angiotensin type 2 receptors mediate natriuresis via angiotensin III in the angiotensin II type 1 receptor-blocked rat. | Hypertension (Dallas, Tex. : 1979) 20060301 |
| Angiotensin II-induced vasodilatation in cerebral arteries is mediated by endothelium-derived hyperpolarising factor. | European journal of pharmacology 20060215 |
| Distinct roles for ANG II and ANG-(1-7) in the regulation of angiotensin-converting enzyme 2 in rat astrocytes. | American journal of physiology. Cell physiology 20060201 |
| Renal angiotensin II AT2 receptors promote natriuresis in streptozotocin-induced diabetic rats. | American journal of physiology. Renal physiology 20060201 |
| Direct regulation of insulin secretion by angiotensin II in human islets of Langerhans. | Diabetologia 20060201 |
| Role of angiotensin II receptor subtypes in porcine basilar artery: functional, radioligand binding, and cell culture studies. | Life sciences 20060125 |
| Opposing actions of angiotensin II type 1 and 2 receptors on plasma cholesterol levels in rats. | Journal of hypertension 20060101 |
| Transactivation of the epidermal growth factor receptor by angiotensin II in glomerular podocytes. | Nephron. Experimental nephrology 20060101 |
| Angiotensin II regulates extraneuronal dopamine uptake in the kidney. | Nephron. Physiology 20060101 |
| Constrictor and dilator effects of angiotensin II on cerebral arterioles. | Stroke 20051201 |
| Reversal of fructose-induced hypertension and insulin resistance by chronic losartan treatment is independent of AT2 receptor activation in rats. | Journal of hypertension 20051201 |
| Neuroprotective effects of candesartan against cerebral ischemia in spontaneously hypertensive rats. | Neuroreport 20051128 |
| Nitric oxide contributes to AT2 but not AT1 angiotensin II receptor-mediated vasodilatation of porcine pial arteries and arterioles. | European journal of pharmacology 20051121 |
| NF-kappaB and chemokine-cytokine expression in renal tubulointerstitium in experimental hyperoxaluria. Role of the renin-angiotensin system. | Urological research 20051101 |
| Biphasic effects of angiotensin II and receptor antagonism on aggregability and protein kinase C phosphorylation in human platelets. | Thrombosis and haemostasis 20051101 |
| NADPH oxidase-derived superoxide anion mediates angiotensin II-induced pressor effect via activation of p38 mitogen-activated protein kinase in the rostral ventrolateral medulla. | Circulation research 20051014 |
| Evidence for a functional interaction of the angiotensin-(1-7) receptor Mas with AT1 and AT2 receptors in the mouse heart. | Hypertension (Dallas, Tex. : 1979) 20051001 |
| Deletion of angiotensin II type 2 receptor exaggerated atherosclerosis in apolipoprotein E-null mice. | Circulation 20050913 |
| Coexpression of AT1 and AT2 receptors by human fibroblasts is associated with resistance to angiotensin II. | Peptides 20050901 |
| ANG II increases 2-deoxyglucose uptake in mouse embryonic stem cells. | Life sciences 20050826 |
| The effect of angiotensin III on protein tyrosine kinase activity in rat pituitary. | Regulatory peptides 20050815 |
| Angiotensin II and interleukin-1 interact to increase generation of dopaminergic neurons from neurospheres of mesencephalic precursors. | Brain research. Developmental brain research 20050808 |
| Angiotensin II induced increase in frequency of cytosolic and nuclear calcium waves of heart cells via activation of AT1 and AT2 receptors. | Peptides 20050801 |
| Tubular expression of angiotensin II receptors and their regulation in IgA nephropathy. | Journal of the American Society of Nephrology : JASN 20050801 |
| Electrophysiological properties of rostral ventrolateral medulla neurons in angiotensin II 1a receptor knockout mice. | Hypertension (Dallas, Tex. : 1979) 20050801 |
| Does the AT2-receptor mediate anti-atherosclerotic actions? | Journal of hypertension 20050801 |
| Angiotensin II infusion increases hepatic triglyceride production via its type 2 receptor in rats. | Journal of hypertension 20050801 |
| Angiotensin II, type 2 receptor is not involved in the angiotensin II-mediated pro-atherogenic process in ApoE-/- mice. | Journal of hypertension 20050801 |
| Blockade of endogenous angiotensin-(1-7) in the hypothalamic paraventricular nucleus reduces renal sympathetic tone. | Hypertension (Dallas, Tex. : 1979) 20050801 |
| In vivo characterization of the angiotensin-(1-7)-induced dopamine and gamma-aminobutyric acid release in the striatum of the rat. | The European journal of neuroscience 20050801 |
| Angiotensin II increases human monocyte matrix metalloproteinase-1 through the AT2 receptor and prostaglandin E2: implications for atherosclerotic plaque rupture. | Journal of leukocyte biology 20050701 |
| Angiotensin II blocks memory consolidation through an AT2 receptor-dependent mechanism. | Psychopharmacology 20050501 |
| AT2 receptors contribute to acute blood pressure-lowering and vasodilator effects of AT1 receptor antagonism in conscious normotensive but not hypertensive rats. | American journal of physiology. Heart and circulatory physiology 20050501 |
| Angiotensin-(1-7) acts as a vasodepressor agent via angiotensin II type 2 receptors in conscious rats. | Hypertension (Dallas, Tex. : 1979) 20050501 |
| Candesartan prevents angiotensin II-induced facilitation of hypoxic neuronal damage through PKCdelta inhibition. | Brain research. Molecular brain research 20050427 |
| Protein kinase C-mediated inhibition of renal Ca2+ ATPase by physiological concentrations of angiotensin II is reversed by AT1- and AT2-receptor antagonists. | Regulatory peptides 20050415 |
| Central angiotensin II AT1 receptors mediate fetal swallowing and pressor responses in the near-term ovine fetus. | American journal of physiology. Regulatory, integrative and comparative physiology 20050401 |
| Angiotensin II receptor inhibition prevents pneumocyte apoptosis in surfactant-depleted rat lungs. | Pediatric pulmonology 20050401 |
| NAD(P)H oxidase inhibition attenuates neuronal chronotropic actions of angiotensin II. | Circulation research 20050401 |
| Deletion of the angiotensin type 2 receptor (AT2R) reduces adipose cell size and protects from diet-induced obesity and insulin resistance. | Diabetes 20050401 |
| The expression of messenger RNA for ADP-ribosyl cyclase in aldosterone-producing adenomas. | Clinical endocrinology 20050401 |
| Diminution of angiotensin II-induced contraction of the abdominal aorta isolated from Watanabe heritable hyperlipidemic rabbits. | Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20050401 |
| Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection. | The New England journal of medicine 20050210 |
| Renal angiotensin II type-2 receptors are upregulated and mediate the candesartan-induced natriuresis/diuresis in obese Zucker rats. | Hypertension (Dallas, Tex. : 1979) 20050201 |
| AT(2) receptors mediate tonic renal medullary vasoconstriction in renovascular hypertension. | British journal of pharmacology 20050201 |
| Angiotensin II-dependent induction of AT(2) receptor expression after renal ablation. | American journal of physiology. Renal physiology 20050101 |
| Angiotensin II receptor modulation of renal vascular resistance and neurotransmission in young and adult spontaneously hypertensive rats. | Kidney & blood pressure research 20050101 |
| Angiotensin subtype-2 receptors inhibit renin biosynthesis and angiotensin II formation. | Hypertension (Dallas, Tex. : 1979) 20050101 |
| Temporal renal expression of angiogenic growth factors and their receptors in experimental diabetes: role of the renin-angiotensin system. | Journal of hypertension 20050101 |
| Reactive oxygen species-mediated signaling pathways in angiotensin II-induced MCP-1 expression of proximal tubular cells. | Antioxidants & redox signaling 20050101 |
| ACE inhibition lowers angiotensin II-induced chemokine expression by reduction of NF-kappaB activity and AT1 receptor expression. | Biochemical and biophysical research communications 20041210 |
| Transforming growth factor beta receptor endoglin is expressed in cardiac fibroblasts and modulates profibrogenic actions of angiotensin II. | Circulation research 20041210 |
| Angiotensin II stimulates Pax-2 in rat kidney proximal tubular cells: impact on proliferation and apoptosis. | Kidney international 20041201 |
| Reactive oxygen species blockade and action of insulin on expression of angiotensinogen gene in proximal tubular cells. | The Journal of endocrinology 20041201 |
| Angiotensin II stimulates arachidonic acid release from bone marrow stromal cells. | Journal of the renin-angiotensin-aldosterone system : JRAAS 20041201 |
| Angiotensin AT2 receptor contributes to cardiovascular remodelling of aged rats during chronic AT1 receptor blockade. | Journal of molecular and cellular cardiology 20041101 |
| Angiotensin II-induced relaxation of anococcygeus smooth muscle via desensitization of AT1 receptor, and activation of AT2 receptor associated with nitric-oxide synthase pathway. | The Journal of pharmacology and experimental therapeutics 20041001 |
| A pharmacological differentiation between postjunctional (AT1A) and prejunctional (AT1B) angiotensin II receptors in the rabbit aorta. | Naunyn-Schmiedeberg's archives of pharmacology 20041001 |
| Angiotensin II attenuates NMDA receptor-mediated neuronal cell death and prevents the associated reduction in Bcl-2 expression. | Brain research. Molecular brain research 20040910 |
| Metabolism of angiotensin II is required for its in vivo effect on dopamine release in the striatum of the rat. | Journal of neurochemistry 20040901 |
| Effect of angiotensin II type 1 receptor on delayed rectifier potassium current in catecholaminergic CATH.a cells. | Acta pharmacologica Sinica 20040901 |
| Angiotensin II increases differentiation of dopaminergic neurons from mesencephalic precursors via angiotensin type 2 receptors. | The European journal of neuroscience 20040901 |
| Angiotensin II and angiotensin-(1-7) inhibit the inner cortex Na+ -ATPase activity through AT2 receptor. | Regulatory peptides 20040815 |
| Interactions between angiotensin II and NF-kappaB-dependent pathways in modulating macrophage infiltration in experimental diabetic nephropathy. | Journal of the American Society of Nephrology : JASN 20040801 |
| The role of the pancreatic renin-angiotensin system in acinar digestive enzyme secretion and in acute pancreatitis. | Regulatory peptides 20040715 |
| Obligatory role for endogenous endothelin in mediating the hypertrophic effects of phenylephrine and angiotensin II in neonatal rat ventricular myocytes: evidence for two distinct mechanisms for endothelin regulation. | The Journal of pharmacology and experimental therapeutics 20040701 |
| Angiotensin II stimulates the release of interleukin-6 and interleukin-8 from cultured human adipocytes by activation of NF-kappaB. | Arteriosclerosis, thrombosis, and vascular biology 20040701 |
| Altered effects of angiotensin ii type 1 and type 2 receptor blockers on cardiac norepinephrine release and inotropic responses during cardiac sympathetic nerve stimulation in aorto-caval shunt rats. | Circulation journal : official journal of the Japanese Circulation Society 20040701 |
| AT2 receptor and apoptosis during AT1 receptor blockade in reperfused myocardial infarction in the rat. | Molecular and cellular biochemistry 20040701 |
| Flow-dependent dilation mediated by endogenous kinins requires angiotensin AT2 receptors. | Circulation research 20040625 |
| Chronic production of angiotensin IV in the brain leads to hypertension that is reversible with an angiotensin II AT1 receptor antagonist. | Circulation research 20040611 |
| Stimulation of cyclic GMP production via AT2 and B2 receptors in the pressure-overloaded aorta after banding. | Hypertension (Dallas, Tex. : 1979) 20040601 |
| Angiotensin II increases Pax-2 expression in fetal kidney cells via the AT2 receptor. | Journal of the American Society of Nephrology : JASN 20040601 |
| Effects of angiotensin II type 1 receptor antagonist on pressor responses to pulsatile compression of the rostral ventrolateral medulla in rats. | Hypertension research : official journal of the Japanese Society of Hypertension 20040601 |
| Angiotensin II type 2 receptor-mediated vasodilation in human coronary microarteries. | Circulation 20040518 |
| Upregulation of angiotensin-converting enzyme 2 after myocardial infarction by blockade of angiotensin II receptors. | Hypertension (Dallas, Tex. : 1979) 20040501 |
| Angiotensin type-1 receptor blockade increases ACE 2 expression in the heart. | Hypertension (Dallas, Tex. : 1979) 20040501 |
| Angiotensin II type-1 receptor blocker valsartan enhances insulin sensitivity in skeletal muscles of diabetic mice. | Hypertension (Dallas, Tex. : 1979) 20040501 |
| Tonic angiotensinergic inputs to neurons in the anterior hypothalamic area of rats. | Brain research 20040501 |
| Angiotensin-(1-7) inhibits the angiotensin II-enhanced norepinephrine release in coarcted hypertensive rats. | Regulatory peptides 20040415 |
| First reported nonpeptide AT1 receptor agonist (L-162,313) acts as an AT2 receptor agonist in vivo. | Journal of medicinal chemistry 20040311 |
| Angiotensin II regulation of the Na+ pump involves the phosphatidylinositol-3 kinase and p42/44 mitogen-activated protein kinase signaling pathways in vascular smooth muscle cells. | Endocrinology 20040301 |
| Regulation of inhibitory protein-kappaB and monocyte chemoattractant protein-1 by angiotensin II type 2 receptor-activated Src homology protein tyrosine phosphatase-1 in fetal vascular smooth muscle cells. | Molecular endocrinology (Baltimore, Md.) 20040301 |
| Involvement of the renin-angiotensin system in endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20040301 |
| Dietary salt intake modulates progression of antithymocyte serum nephritis through alteration of glomerular angiotensin II receptor expression. | American journal of physiology. Renal physiology 20040201 |
| Prophylactic and therapeutic treatments with AT 1 and AT 2 receptor antagonists and their effects on changes in the severity of pancreatitis. | The international journal of biochemistry & cell biology 20040201 |
| Retinal expression of vascular endothelial growth factor is mediated by angiotensin type 1 and type 2 receptors. | Hypertension (Dallas, Tex. : 1979) 20040201 |
| Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets. | Diabetologia 20040201 |
| Different AT1 receptor subtypes at pre- and postjunctional sites: AT1A versus AT1B receptors. | Journal of cardiovascular pharmacology 20040101 |
| Tubular and interstitial cell apoptosis in the streptozotocin-diabetic rat kidney. | Nephron. Experimental nephrology 20040101 |
| Increase in systemic blood pressure during intra-arterial PD123319 infusion: evidence for functional expression of angiotensin type 2 receptors in normal volunteers. | Blood pressure 20040101 |
| Importance of the angiotensin type 1 receptor in angiotensin II-induced bronchoconstriction and bronchial hyperresponsiveness in the guinea pig. | Experimental lung research 20040101 |
| Increased renal vascular endothelial growth factor and angiopoietins by angiotensin II infusion is mediated by both AT1 and AT2 receptors. | Journal of the American Society of Nephrology : JASN 20031201 |
| Angiotensin II mediates Tyr-dephosphorylation in rat fetal kidney membranes. | Molecular and cellular biochemistry 20031201 |
| Effect of angiotensin II type 2 receptor blockade on activation of mitogen-activated protein kinases after ischemia-reperfusion in isolated working rat hearts. | Journal of cardiovascular pharmacology and therapeutics 20031201 |
| Evidence for a functional role of angiotensin II type 2 receptor in the cardiac hypertrophic process in vivo in the rat heart. | Circulation 20031111 |
| Responses to GABA-A receptor blockade in the hypothalamic PVN are attenuated by local AT1 receptor antagonism. | American journal of physiology. Regulatory, integrative and comparative physiology 20031101 |
| Effects of angiotensin II on nitric oxide generation in growing and resting rat aortic endothelial cells. | Journal of hypertension 20031101 |
| Angiotensin II type 2 receptor inhibits prorenin processing in juxtaglomerular cells. | Hypertension research : official journal of the Japanese Society of Hypertension 20031101 |
| Angiotensin AT2 receptors directly stimulate renal nitric oxide in bradykinin B2-receptor-null mice. | Hypertension (Dallas, Tex. : 1979) 20031001 |
| Connective tissue growth factor is a mediator of angiotensin II-induced fibrosis. | Circulation 20030923 |
| Angiotensin II type 2 receptor inhibits vascular endothelial growth factor-induced migration and in vitro tube formation of human endothelial cells. | Circulation research 20030905 |
| Patients with steroid refractory acute vascular rejection develop agonistic antibodies targeting angiotensin II type 1 receptor. | Transplantation proceedings 20030901 |
| Effects of angiotensin II on nitric oxide generation in proliferating and quiescent rat coronary microvascular endothelial cells. | Hypertension research : official journal of the Japanese Society of Hypertension 20030901 |
| Disparate roles of AT2 receptors in the renal cortical and medullary circulations of anesthetized rabbits. | Hypertension (Dallas, Tex. : 1979) 20030801 |
| Myogenic constriction is increased in mesenteric resistance arteries from rats with chronic heart failure: instantaneous counteraction by acute AT1 receptor blockade. | British journal of pharmacology 20030801 |
| Angiotensin II and III microinjections into the zona incerta influence drinking behavior. | Brain research 20030711 |
| Effects of ANG II type 1 and 2 receptors on oxidative stress, renal NADPH oxidase, and SOD expression. | American journal of physiology. Regulatory, integrative and comparative physiology 20030701 |
| Angiotensin II stimulates spinally projecting paraventricular neurons through presynaptic disinhibition. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030615 |
| Angiotensin II type 1 receptor antagonists inhibit basal as well as low-density lipoprotein and platelet-activating factor-stimulated human monocyte chemoattractant protein-1. | The Journal of pharmacology and experimental therapeutics 20030601 |
| Effect of angiotensin AT2 receptor stimulation on vascular cyclic GMP production in normotensive Wistar Kyoto rats. | The international journal of biochemistry & cell biology 20030601 |
| An AT1-receptor antagonist and an angiotensin-converting enzyme inhibitor protect against hypoxia-induced apoptosis in human aortic endothelial cells through upregulation of endothelial cell nitric oxide synthase activity. | Shock (Augusta, Ga.) 20030601 |
| No involvement of the AT2-receptor in angiotensin II-enhanced sympathetic transmission in vitro. | Journal of the renin-angiotensin-aldosterone system : JRAAS 20030601 |
| Biphasic effects of angiotensin (1-7) and its interactions with angiotensin II in rat aorta. | Journal of the renin-angiotensin-aldosterone system : JRAAS 20030601 |
| Angiotensin II AT(1) and AT(2) receptors contribute to maintain basal adrenomedullary norepinephrine synthesis and tyrosine hydroxylase transcription. | Endocrinology 20030501 |
| Localization of AT(2) receptors in the nucleus of the solitary tract of spontaneously hypertensive and Wistar Kyoto rats using [125I] CGP42112: upregulation of a non-angiotensin II binding site following unilateral nodose ganglionectomy. | Brain research 20030404 |
| Cysteinyl leukotriene-dependent [Ca2+]i responses to angiotensin II in cardiomyocytes. | American journal of physiology. Heart and circulatory physiology 20030401 |
| Influence of angiotensin II receptor subtypes of the paraventricular nucleus on the physiological responses induced by angiotensin II injection into the medial septal area. | Arquivos brasileiros de cardiologia 20030401 |
| Angiotensin II-induced release of oxytocin: interaction with norepinephrine and role in lactation. | Regulatory peptides 20030328 |
| The effects of sarmesin, an Angiotensin II analogue on seizure susceptibility, memory retention and nociception. | Regulatory peptides 20030328 |
| ANG II AT2 receptor modulates AT1 receptor-mediated descending vasa recta endothelial Ca2+ signaling. | American journal of physiology. Heart and circulatory physiology 20030301 |
| Role of the angiotensin II system in regulation of ovulation and blood flow in the rat ovary. | Reproduction (Cambridge, England) 20030301 |
| Cardiac myofibroblasts: a novel source of vascular endothelial growth factor (VEGF) and its receptors Flt-1 and KDR. | Journal of molecular and cellular cardiology 20030301 |
| Divergent roles of angiotensin II AT1 and AT2 receptors in modulating coronary microvascular function. | Circulation research 20030221 |
| Angiotensin receptors contribute to blood pressure homeostasis in salt-depleted SHR. | American journal of physiology. Regulatory, integrative and comparative physiology 20030101 |
| Angiotensin II type 2 receptor blockade partially negates antihypertrophic effects of type 1 receptor blockade on pressure-overload rat cardiac hypertrophy. | Hypertension research : official journal of the Japanese Society of Hypertension 20030101 |
| Effect of neutral endopeptidase inhibition on vascular response induced by exogenous angiotensin I in the isolated rat lung. | Polish journal of pharmacology 20030101 |
| Prejunctional AT(1) receptor subtype-dependent modification of neurotransmitter releases in canine isolated splenic arteries. | Autonomic & autacoid pharmacology 20030101 |
| Tumor necrosis factor-alpha-induced AT1 receptor upregulation enhances angiotensin II-mediated cardiac fibroblast responses that favor fibrosis. | Circulation research 20021213 |
| Biphasic regulation of Na+-HCO3- cotransporter by angiotensin II type 1A receptor. | Hypertension (Dallas, Tex. : 1979) 20021101 |
| Antithrombotic effect of captopril and losartan is mediated by angiotensin-(1-7). | Hypertension (Dallas, Tex. : 1979) 20021101 |
| Dose-dependent regulation of NAD(P)H oxidase expression by angiotensin II in human endothelial cells: protective effect of angiotensin II type 1 receptor blockade in patients with coronary artery disease. | Arteriosclerosis, thrombosis, and vascular biology 20021101 |
| Cross-talk between AT(1) and AT(2) angiotensin receptors in rat anococcygeus smooth muscle. | The Journal of pharmacology and experimental therapeutics 20021001 |
| Interaction between paraventricular nucleus and septal area in the control of physiological responses induced by angiotensin II. | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20020901 |
| Effect of intranasal administration of CV-11974, a type 1 angiotensin II receptor antagonist, on airway hyperresponsiveness and airway inflammation induced by antigen inhalation in guinea pigs. | International archives of allergy and immunology 20020901 |
| Involvement of the AT(2)-receptor in angiotensin II-induced facilitation of sympathetic neurotransmission. | Journal of the renin-angiotensin-aldosterone system : JRAAS 20020901 |
| Effects of AT1 and AT2 receptor blockade on angiotensin II induced apoptosis of human renal proximal tubular epithelial cells. | Wiener klinische Wochenschrift 20020830 |
| Angiotensin actions on the isolated rat uterus during the estrous cycle: influence of resting membrane potential and uterine morphology. | Pharmacology 20020701 |
| Angiotensin II induces apoptosis in rat glomerular epithelial cells. | American journal of physiology. Renal physiology 20020701 |
| Angiotensin type 2 receptor antagonism confers renal protection in a rat model of progressive renal injury. | Journal of the American Society of Nephrology : JASN 20020701 |
| Aldosterone breakthrough during angiotensin II receptor antagonist therapy in stroke-prone spontaneously hypertensive rats. | Hypertension (Dallas, Tex. : 1979) 20020701 |
| Differences in AT2 -receptor stimulation between AT1 -receptor blockers valsartan and losartan quantified by renal interstitial fluid cGMP. | Journal of hypertension 20020601 |
| Angiotensin II angiogenic effect in vivo involves vascular endothelial growth factor- and inflammation-related pathways. | Laboratory investigation; a journal of technical methods and pathology 20020601 |
| 125I[Sar(1)Ile(8)] angiotensin II has a different affinity for AT(1) and AT(2) receptor subtypes in ovine tissues. | Regulatory peptides 20020515 |
| Role of angiotensin II and angiotensin II receptors in vascular smooth muscle cell migration in vitro. | Chinese medical journal 20020501 |
| AT(2) but not AT(1) receptor antagonism abolishes angiotensin II increase of the acquisition of conditioned avoidance responses in rats. | Behavioural brain research 20020401 |
| Angiotensin receptor subtype AT(1) mediates alveolar epithelial cell apoptosis in response to ANG II. | American journal of physiology. Lung cellular and molecular physiology 20020401 |
| AT(1) and AT(2) receptor expression and blockade after acute ischemia-reperfusion in isolated working rat hearts. | American journal of physiology. Heart and circulatory physiology 20020401 |
| Influence of estrogen and/or progesterone on isolated ovariectomized rat uterus. Responsiveness to Ang II. | Pharmacology 20020401 |
| Angiotensin protects cortical neurons from hypoxic-induced apoptosis via the angiotensin type 2 receptor. | Brain research. Molecular brain research 20020328 |
| Comparison of angiotensin II (Ang II) effects in the internal anal sphincter (IAS) and lower esophageal sphincter smooth muscles. | Life sciences 20020322 |
| Vasodilator action of angiotensin-(1-7) on isolated rabbit afferent arterioles. | Hypertension (Dallas, Tex. : 1979) 20020301 |
| Forearm vasodilator response to angiotensin II in elderly women receiving candesartan: role of AT(2)- receptors. | Journal of the renin-angiotensin-aldosterone system : JRAAS 20020301 |
| Angiotensin II stimulates migration of retinal microvascular pericytes: involvement of TGF-beta and PDGF-BB. | American journal of physiology. Heart and circulatory physiology 20020201 |
| The mechanism of angiotensin II binding downregulation by high glucose in primary renal proximal tubule cells. | American journal of physiology. Renal physiology 20020201 |
| Angiotensin II directly stimulates macula densa Na-2Cl-K cotransport via apical AT(1) receptors. | American journal of physiology. Renal physiology 20020201 |
| Dilatation of cerebral parenchymal vessels mediated by angiotensin type 1 receptor in cats. | Neuroscience letters 20020125 |
| Angiotensin-(1-7) reverts the stimulatory effect of angiotensin II on the proximal tubule Na(+)-ATPase activity via a A779-sensitive receptor. | Regulatory peptides 20020115 |
| Chronic hypotensive effects of losartan are not dependent on the actions of angiotensin II at AT 2 receptors. | Journal of cardiovascular pharmacology 20020101 |
| Angiotensin peptides modulate bradykinin levels in the interstitium of the dog heart in vivo. | The Journal of pharmacology and experimental therapeutics 20020101 |
| Differential effect of angiotensin II on blood circulation in the renal medulla and cortex of anaesthetised rats. | The Journal of physiology 20020101 |
| Vasoconstriction is determined by interstitial rather than circulating angiotensin II. | British journal of pharmacology 20020101 |
| Angiotensin II type 2 receptor counter-regulates type 1 receptor in catecholamine synthesis in cultured porcine adrenal medullary chromaffin cells. | Hypertension (Dallas, Tex. : 1979) 20020101 |
| Angiotensin II in cardiac pressure-overload hypertrophy in fetal sheep. | American journal of physiology. Regulatory, integrative and comparative physiology 20011201 |
| AT(2) receptor-mediated vasodilation in the heart: effect of myocardial infarction. | American journal of physiology. Heart and circulatory physiology 20011201 |
| Regulation of vascular proteoglycan synthesis by angiotensin II type 1 and type 2 receptors. | Journal of the American Society of Nephrology : JASN 20011201 |
| Intracellular angiotensin II inhibits heterologous receptor stimulated Ca2+ entry. | Life sciences 20011130 |
| Angiotensin subtype-2 receptor (AT2 ) negatively regulates subtype-1 receptor (AT1 ) in signal transduction pathways in cultured porcine adrenal medullary chromaffin cells. | Journal of hypertension 20011101 |
| Autoradiographic determination of angiotensin II receptors in prepubertal and postpubertal pig ovarian tissue. | Reproduction (Cambridge, England) 20011101 |
| Corpuscles of Stannius secrete renin or an isorenin that regulates cardiovascular function in freshwater North American eels, Anguilla rostrata LeSueur. | General and comparative endocrinology 20011101 |
| Blockade of angiotensin receptor subtypes in arcuate uterine artery of pregnant and postpartum rats. | Hypertension (Dallas, Tex. : 1979) 20011101 |
| Identification and characterization of functional angiotensin II type 1 receptors on immortalized human fetal aortic vascular smooth muscle cells. | Molecular and cellular endocrinology 20011025 |
| Increased AT(1) receptors in adrenal gland of AT(2) receptor gene-disrupted mice. | Regulatory peptides 20011015 |
| Angiotensin II induces circadian gene expression of clock genes in cultured vascular smooth muscle cells. | Circulation 20011009 |
| Angiotensin II enhances noradrenaline release from sympathetic nerves of the rat prostate via a novel angiotensin receptor: implications for the pathophysiology of benign prostatic hyperplasia. | The Journal of endocrinology 20011001 |
| Role of AT1 and AT2 receptor subtypes in salt-sensitive hypertension induced by sensory nerve degeneration. | Journal of hypertension 20011001 |
| Antagonism of AT2 receptors augments angiotensin II-induced abdominal aortic aneurysms and atherosclerosis. | British journal of pharmacology 20011001 |
| Angiotensin II type 2 receptor inhibits epidermal growth factor receptor transactivation by increasing association of SHP-1 tyrosine phosphatase. | Hypertension (Dallas, Tex. : 1979) 20010901 |
| Angiotensin II type AT(2) receptor mRNA expression and renal vasodilatation are increased in renal failure. | Hypertension (Dallas, Tex. : 1979) 20010901 |
| No effect of angiotensin II AT(2)-receptor antagonist PD 123319 on cerebral blood flow autoregulation. | Journal of the renin-angiotensin-aldosterone system : JRAAS 20010901 |
| Identification of angiotensin II type 2 (AT2) receptor domains mediating high-affinity CGP 42112A binding and receptor activation. | The Journal of pharmacology and experimental therapeutics 20010801 |
| Angiotensin II AT(2) receptors inhibit growth responses in proximal tubule cells. | American journal of physiology. Renal physiology 20010801 |
| Tyrosine hydroxylase phosphorylation in bovine adrenal chromaffin cells: the role of MAPKs after angiotensin II stimulation. | Journal of neurochemistry 20010801 |
| Angiotensin-converting enzyme inhibition potentiates angiotensin II type 1 receptor effects on renal bradykinin and cGMP. | Hypertension (Dallas, Tex. : 1979) 20010801 |
| Combined angiotensin converting enzyme inhibition and angiotensin AT(1) receptor blockade up-regulates myocardial AT(2) receptors in remodeled myocardium post-infarction. | Cardiovascular research 20010701 |
| Activation of angiotensin II subtype 2 receptor induces catecholamine release in an extracellular Ca(2+)-dependent manner through a decrease of cyclic guanosine 3',5'-monophosphate production in cultured porcine adrenal medullary chromaffin Cells. | Endocrinology 20010701 |
| Effect of angiotensin II on calcium reabsorption by the luminal membranes of the nephron. | American journal of physiology. Endocrinology and metabolism 20010601 |
| Endogenous angiotensin II in the NTS contributes to sympathetic activation in rats with aortocaval shunt. | American journal of physiology. Regulatory, integrative and comparative physiology 20010601 |
| Coronary hemodynamic and ventricular responses to angiotensin type 1 receptor inhibition in SHR: interaction with angiotensin type 2 receptors. | Hypertension (Dallas, Tex. : 1979) 20010601 |
| Angiotensin II-induced stimulation of collagen secretion and production in cardiac fibroblasts is mediated via angiotensin II subtype 1 receptors. | Journal of the renin-angiotensin-aldosterone system : JRAAS 20010601 |
| Intracellular angiotensin II elicits Ca2+ increases in A7r5 vascular smooth muscle cells. | European journal of pharmacology 20010518 |
| Angiotensin II AT1 receptors preserve vasodilator reactivity in skeletal muscle resistance arteries. | American journal of physiology. Heart and circulatory physiology 20010501 |
| Systemic infusion of angiotensin II into normal rats activates nuclear factor-kappaB and AP-1 in the kidney: role of AT(1) and AT(2) receptors. | The American journal of pathology 20010501 |
| Chronotropic effect of angiotensin II via type 2 receptors in rat brain neurons. | Journal of neurophysiology 20010501 |
| Angiotensin II type I receptor modulates intracellular free Mg2+ in renally derived cells via Na+-dependent Ca2+-independent mechanisms. | The Journal of biological chemistry 20010427 |
| Atypical angiotensin receptors may mediate water intake induced by central injections of angiotensin II and of serotonin in pigeons. | Regulatory peptides 20010420 |
| Angiotensin receptor in the heart of Bothrops jararaca snake. | European journal of pharmacology 20010406 |
| Tonic suppression of spontaneous baroreceptor reflex by endogenous angiotensins via AT(2) subtype receptors at nucleus reticularis ventrolateralis in the rat. | Synapse (New York, N.Y.) 20010401 |
| Mechanisms of angiotensin-(1-7)-induced inhibition of angiogenesis. | American journal of physiology. Regulatory, integrative and comparative physiology 20010401 |
| Brain angiotensin receptors and sympathoadrenal regulation during insulin-induced hypoglycemia. | American journal of physiology. Regulatory, integrative and comparative physiology 20010401 |
| Intracellular Angiotensin II and cell growth of vascular smooth muscle cells. | British journal of pharmacology 20010401 |
| At receptor inhibition affects the noradrenaline sensitivity in isolated portal vein of normotensive rat. | Clinical and experimental hypertension (New York, N.Y. : 1993) 20010401 |
| Mechanism of the cardioprotective effect of inhibition of the renin-angiotensin system on ischemia/reperfusion-induced myocardial injury. | Hypertension research : official journal of the Japanese Society of Hypertension 20010301 |
| Hyperoxia/normoxia-driven retinal angiogenesis in mice: a role for angiotensin II. | Investigative ophthalmology & visual science 20010201 |
| Transcriptional and translational regulation of calpain in the rat heart after myocardial infarction--effects of AT(1) and AT(2) receptor antagonists and ACE inhibitor. | British journal of pharmacology 20010201 |
| Angiotensin II relaxes microvessels via the AT(2) receptor and Ca(2+)-activated K(+) (BK(Ca)) channels. | Hypertension (Dallas, Tex. : 1979) 20010201 |
| p38 Map kinase regulates vascular smooth muscle cell collagen synthesis by angiotensin II in SHR but not in WKY. | Hypertension (Dallas, Tex. : 1979) 20010201 |
| Regulation of K+ transport in the rat distal colon via angiotensin II subtype receptors and K+ -pathways. | Acta physiologica Scandinavica 20010201 |
| Central AT1 and AT2 receptors mediate chronic intracerebroventricular angiotensin II-induced drinking in rats fed high sodium chloride diet from weaning. | Acta physiologica Scandinavica 20010201 |
| Angiotensin AT(1) and AT(2) receptors differentially regulate angiopoietin-2 and vascular endothelial growth factor expression and angiogenesis by modulating heparin binding-epidermal growth factor (EGF)-mediated EGF receptor transactivation. | Circulation research 20010119 |
| Glial angiotensinogen regulates brain angiotensin II receptors in transgenic rats TGR(ASrAOGEN). | American journal of physiology. Regulatory, integrative and comparative physiology 20010101 |
| Increased AT(1) receptor expression and mRNA in kidney glomeruli of AT(2) receptor gene-disrupted mice. | American journal of physiology. Renal physiology 20010101 |
| Functional expression of angiotensin II receptors in type-I cells of the rat carotid body. | Pflugers Archiv : European journal of physiology 20010101 |
| Angiotensin II activates nuclear transcription factor-kappaB in aorta of normal rats and in vascular smooth muscle cells of AT1 knockout mice. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20010101 |
| Angiotensin type 2 receptor is expressed in the adult rat kidney and promotes cellular proliferation and apoptosis. | Kidney international 20001201 |
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| Angiotensin in the nucleus tractus solitarii contributes to neurogenic hypertension caused by chronic nitric oxide synthase inhibition. | Hypertension (Dallas, Tex. : 1979) 20000801 |
| Interaction of mRNAs for angiotensin II type 1 and type 2 receptors to vascular remodeling in spontaneously hypertensive rats. | Hypertension (Dallas, Tex. : 1979) 19980901 |
| Angiotensin receptor blockade blunts hyperinsulinemia-induced hypertension in rats. | Hypertension (Dallas, Tex. : 1979) 19980801 |
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| Regulated expression of angiotensin II (AT2) binding sites in R3T3 cells. | Regulatory peptides 19930319 |
| Characterization of distinct angiotensin II binding sites in rat adrenal gland and bovine cerebellum using selective nonpeptide antagonists. | Journal of cardiovascular pharmacology 19910201 |
| Subclasses of angiotensin II binding sites and their functional significance. | Molecular pharmacology 19900901 |
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