CAS 13058-04-3 | Diphosphoric acid, P-(3,7,11-trimethyl-2,6,10-dodecatrien-1-yl) ester | CAS Number 13058-04-3

Title	Journal
Tetraterpene Synthase Substrate and Product Specificity in the Green Microalga Botryococcus braunii Race L.	ACS chemical biology 20170915
Molecular cloning and functional analysis of a 10-epi-junenol synthase from Inula hupehensis.	Plant physiology and biochemistry : PPB 20160901
Mechanistic Characterisation of Two Sesquiterpene Cyclases from the Plant Pathogenic Fungus Fusarium fujikuroi.	Angewandte Chemie (International ed. in English) 20160718
Conformational Analysis, Thermal Rearrangement, and EI-MS Fragmentation Mechanism of (1(10)E,4E,6S,7R)-Germacradien-6-ol by (13)C-Labeling Experiments.	Angewandte Chemie (International ed. in English) 20151102
Undecaprenyl diphosphate synthase, a cis-prenyltransferase synthesizing lipid carrier for bacterial cell wall biosynthesis.	Molecular membrane biology 20121101
Heterologous expression of pentalenene synthase (PSS) from Streptomyces UC5319 in Xanthophyllomyces dendrorhous.	Journal of biotechnology 20121031
2C-Methyl-d-erythritol 4-phosphate enhances and sustains cyclodiphosphate synthase IspF activity.	ACS chemical biology 20121019
Functional analysis and molecular docking identify two active short-chain prenyltransferases in the green peach aphid, Myzus persicae.	Archives of insect biochemistry and physiology 20121001
Identification and characterization of a cis,trans-mixed heptaprenyl diphosphate synthase from Arabidopsis thaliana.	The FEBS journal 20121001
Chemoenzymatic synthesis of an isoprenoid phosphate tool for the analysis of complex bacterial oligosaccharide biosynthesis.	Carbohydrate research 20121001
Structures, mechanisms and inhibitors of undecaprenyl diphosphate synthase: a cis-prenyltransferase for bacterial peptidoglycan biosynthesis.	Bioorganic chemistry 20120801
Brain isoprenoids farnesyl pyrophosphate and geranylgeranyl pyrophosphate are increased in aged mice.	Molecular neurobiology 20120801
Development of petri net-based dynamic model for improved production of farnesyl pyrophosphate by integrating mevalonate and methylerythritol phosphate pathways in yeast.	Applied biochemistry and biotechnology 20120701
Simvastatin decreases invasiveness of human endometrial stromal cells.	Biology of reproduction 20120701
Farnesyl pyrophosphate is an endogenous antagonist to ADP-stimulated P2Y₁₂ receptor-mediated platelet aggregation.	Thrombosis and haemostasis 20120701
Investigating conservation of the albaflavenone biosynthetic pathway and CYP170 bifunctionality in streptomycetes.	The FEBS journal 20120501
A 1,6-ring closure mechanism for (+)-δ-cadinene synthase?	Journal of the American Chemical Society 20120404
NMR for direct determination of K(m) and V(max) of enzyme reactions based on the Lambert W function-analysis of progress curves.	Biochimica et biophysica acta 20120301
Identification, functional characterization, and regulation of the enzyme responsible for floral (E)-nerolidol biosynthesis in kiwifruit (Actinidia chinensis).	Journal of experimental botany 20120301
Nonradioactive assay for detecting isoprenyl diphosphate synthase activity in crude plant extracts using liquid chromatography coupled with tandem mass spectrometry.	Analytical biochemistry 20120301
Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation.	Neuroscience 20120127
Simvastatin reduces steroidogenesis by inhibiting Cyp17a1 gene expression in rat ovarian theca-interstitial cells.	Biology of reproduction 20120101
Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity.	Natural product reports 20120101
Steady-state kinetic characterization of sesquiterpene synthases by gas chromatography-mass spectroscopy.	Methods in enzymology 20120101
Quantitative proteomic analysis revealed lovastatin-induced perturbation of cellular pathways in HL-60 cells.	Journal of proteome research 20111202
Induction of isoprenyl diphosphate synthases, plant hormones and defense signalling genes correlates with traumatic resin duct formation in Norway spruce (Picea abies).	Plant molecular biology 20111201
Subcellular evidence for the involvement of peroxisomes in plant isoprenoid biosynthesis.	Plant signaling & behavior 20111201
Computational identification of sweet wormwood (Artemisia annua) microRNA and their mRNA targets.	Genomics, proteomics & bioinformatics 20111201
A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro.	Journal of lipid research 20111101
Resveratrol inhibits the mevalonate pathway and potentiates the antiproliferative effects of simvastatin in rat theca-interstitial cells.	Fertility and sterility 20111101
Identification of bottlenecks in Escherichia coli engineered for the production of CoQ(10).	Metabolic engineering 20111101
Protein prenylation contributes to the effects of LPS on EFS-induced responses in human isolated bronchi.	American journal of respiratory cell and molecular biology 20111001
Pleiotropic effects of a schweinfurthin on isoprenoid homeostasis.	Lipids 20111001
Metabolically regulated endoplasmic reticulum-associated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase: evidence for requirement of a geranylgeranylated protein.	The Journal of biological chemistry 20110916
Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist.	The Biochemical journal 20110815
Isoprenoid is a perfect fit for fat factor.	The Biochemical journal 20110815
Characterization of a novel sesquiterpene cyclase involved in (+)-caryolan-1-ol biosynthesis in Streptomyces griseus.	The Journal of biological chemistry 20110812
Effects of farnesyl pyrophosphate accumulation on calvarial osteoblast differentiation.	Endocrinology 20110801
New synthetic methodology for the construction of 7-substituted farnesyl diphosphate analogs.	Organic letters 20110715
Isopentenyl pyrophosphate is a novel antinociceptive substance that inhibits TRPV3 and TRPA1 ion channels.	Pain 20110501
Geranylgeranylation facilitates proteasomal degradation of rho G-proteins in human trabecular meshwork cells.	Investigative ophthalmology & visual science 20110325
Cloning and characterization of an Armillaria gallica cDNA encoding protoilludene synthase, which catalyzes the first committed step in the synthesis of antimicrobial melleolides.	The Journal of biological chemistry 20110304
Crystal structure of heterodimeric hexaprenyl diphosphate synthase from Micrococcus luteus B-P 26 reveals that the small subunit is directly involved in the product chain length regulation.	The Journal of biological chemistry 20110204
Rv0989c encodes a novel (E)-geranyl diphosphate synthase facilitating decaprenyl diphosphate biosynthesis in Mycobacterium tuberculosis.	FEBS letters 20110204
Genome mining in Streptomyces clavuligerus: expression and biochemical characterization of two new cryptic sesquiterpene synthases.	Chemistry & biology 20110128
Geranylgeranyl-pyrophosphate regulates secretion of pentraxin 3 and monocyte chemoattractant protein-1 from rheumatoid fibroblast-like synoviocytes in distinct manners.	Clinical and experimental rheumatology 20110101
Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts.	Respiratory research 20110101
Nuclear receptor engineering based on novel structure activity relationships revealed by farnesyl pyrophosphate.	Protein engineering, design & selection : PEDS 20101101
Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway.	Biotechnology and bioengineering 20101015
A rapid and sensitive assay for determining human brain levels of farnesyl-(FPP) and geranylgeranylpyrophosphate (GGPP) and transferase activities using UHPLC-MS/MS.	Analytical and bioanalytical chemistry 20101001
Mechanism of cis-prenyltransferase reaction probed by substrate analogues.	Biochemical and biophysical research communications 20101001
Enantioselective inhibition of squalene synthase by aziridine analogues of presqualene diphosphate.	The Journal of organic chemistry 20100716
Genome mining in Streptomyces avermitilis: cloning and characterization of SAV_76, the synthase for a new sesquiterpene, avermitilol.	Journal of the American Chemical Society 20100707
Pitavastatin strengthens the barrier integrity in primary cultures of rat brain endothelial cells.	Cellular and molecular neurobiology 20100701
Total synthesis: towards artificial terpene cyclases.	Nature chemistry 20100701
Anticancer activity of novel unnatural synthetic isoprenoids.	Anticancer research 20100701
Farnesyl pyrophosphate is a novel pain-producing molecule via specific activation of TRPV3.	The Journal of biological chemistry 20100618
Modulation of cholesterol, farnesylpyrophosphate, and geranylgeranylpyrophosphate in neuroblastoma SH-SY5Y-APP695 cells: impact on amyloid beta-protein production.	Molecular neurobiology 20100601
Sesquiterpene synthases Cop4 and Cop6 from Coprinus cinereus: catalytic promiscuity and cyclization of farnesyl pyrophosphate geometric isomers.	Chembiochem : a European journal of chemical biology 20100517
Lipophilic but not hydrophilic statins selectively induce cell death in gynaecological cancers expressing high levels of HMGCoA reductase.	Journal of cellular and molecular medicine 20100501
Enhancement of farnesyl diphosphate pool as direct precursor of sesquiterpenes through metabolic engineering of the mevalonate pathway in Saccharomyces cerevisiae.	Biotechnology and bioengineering 20100501
Functional characterization of the atypical integral membrane lipid phosphatase PDP1/PPAPDC2 identifies a pathway for interconversion of isoprenols and isoprenoid phosphates in mammalian cells.	The Journal of biological chemistry 20100430
Farnesyl diphosphate synthase attenuates paclitaxel-induced apoptotic cell death in human glioblastoma U87MG cells.	Neuroscience letters 20100426
Bisabolyl-derived sesquiterpenes from tobacco 5-epi-aristolochene synthase-catalyzed cyclization of (2Z,6E)-farnesyl diphosphate.	Journal of the American Chemical Society 20100331
Doubly deuterium-labeled patchouli alcohol from cyclization of singly labeled [2-(2)H(1)]farnesyl diphosphate catalyzed by recombinant patchoulol synthase.	Journal of the American Chemical Society 20100310
Differential activities of thalidomide and isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells.	Leukemia research 20100301
Geranylgeranyl diphosphate synthase genes in entomopathogenic fungi.	Applied microbiology and biotechnology 20100201
Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study.	Phytochemistry 20100201
A bifunctional geranyl and geranylgeranyl diphosphate synthase is involved in terpene oleoresin formation in Picea abies.	Plant physiology 20100201
In vitro synthesis of high molecular weight rubber by Hevea small rubber particles.	Journal of bioscience and bioengineering 20100201
Stabilization and translocation of p53 to mitochondria is linked to Bax translocation to mitochondria in simvastatin-induced apoptosis.	Biochemical and biophysical research communications 20100122
Farnesyl pyrophosphate inhibits epithelialization and wound healing through the glucocorticoid receptor.	The Journal of biological chemistry 20100115
Towards the synthesis of bisubstrate inhibitors of protein farnesyltransferase: Synthesis and biological evaluation of new farnesylpyrophosphate analogues.	Bioorganic & medicinal chemistry 20100115
Synthesis, properties, and applications of diazotrifluropropanoyl-containing photoactive analogs of farnesyl diphosphate containing modified linkages for enhanced stability.	Chemical biology & drug design 20100101
Distribution of endogenous farnesyl pyrophosphate and four species of lysophosphatidic acid in rodent brain.	International journal of molecular sciences 20100101
Crystal structure of albaflavenone monooxygenase containing a moonlighting terpene synthase active site.	The Journal of biological chemistry 20091225
Geranylgeranyl pyrophosphate is a potent regulator of HRD-dependent 3-Hydroxy-3-methylglutaryl-CoA reductase degradation in yeast.	The Journal of biological chemistry 20091218
Role of isoprenylation in simvastatin-induced inhibition of ovarian theca-interstitial growth in the rat.	Biology of reproduction 20091101
Quantitative determination of geranyl diphosphate levels in cultured human cells.	Lipids 20091101
Modes of inactivation of trichodiene synthase by a cyclopropane-containing farnesyldiphosphate analog.	Organic & biomolecular chemistry 20091007
Novel approaches and achievements in biosynthesis of functional isoprenoids in Escherichia coli.	Applied microbiology and biotechnology 20091001
P2Y5 is a G(alpha)i, G(alpha)12/13 G protein-coupled receptor activated by lysophosphatidic acid that reduces intestinal cell adhesion.	American journal of physiology. Gastrointestinal and liver physiology 20091001
Structural features conferring dual geranyl/farnesyl diphosphate synthase activity to an aphid prenyltransferase.	Insect biochemistry and molecular biology 20091001
Orphan endogenous lipids and orphan GPCRs: a good match.	Prostaglandins & other lipid mediators 20090901
Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases Potential relationship with the effect of bisphosphonates on osteoclasts.	Biochemical pharmacology 20090815
Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients.	Neurobiology of disease 20090801
Synthesis of imidazole-containing analogues of farnesyl pyrophosphate and evaluation of their biological activity on protein farnesyltransferase.	Journal of enzyme inhibition and medicinal chemistry 20090801
A versatile photoactivatable probe designed to label the diphosphate binding site of farnesyl diphosphate utilizing enzymes.	Bioorganic & medicinal chemistry 20090701
Biosynthesis of the sesquiterpene botrydial in Botrytis cinerea. Mechanism and stereochemistry of the enzymatic formation of presilphiperfolan-8beta-ol.	Journal of the American Chemical Society 20090624
Cholesterol biosynthesis modulation regulates dengue viral replication.	Virology 20090620
Statins induce apoptosis in ovarian cancer cells through activation of JNK and enhancement of Bim expression.	Cancer chemotherapy and pharmacology 20090501
Cloning and characterization of a squalene synthase gene from a petroleum plant, Euphorbia tirucalli L.	Planta 20090501
Simvastatin inhibits induction of matrix metalloproteinase-9 in rat alveolar macrophages exposed to cigarette smoke extract.	Experimental & molecular medicine 20090430
Global gene regulation by Fusarium transcription factors Tri6 and Tri10 reveals adaptations for toxin biosynthesis.	Molecular microbiology 20090401
Lysophosphatidylcholine increases Na+/Ca2+ exchanger expression via RhoB-geranylgeranylation in H9c2 cells.	Journal of pharmacological sciences 20090401
6- and 14-Fluoro farnesyl diphosphate: mechanistic probes for the reaction catalysed by aristolochene synthase.	Organic & biomolecular chemistry 20090307
An insect farnesyl phosphatase homologous to the N-terminal domain of soluble epoxide hydrolase.	Biochemical and biophysical research communications 20090227
Different reaction mechanisms for cis- and trans-prenyltransferases.	Biochemical and biophysical research communications 20090206
Role for protein geranylgeranylation in adult T-cell leukemia cell survival.	Experimental cell research 20090115
A novel pathway for sesquiterpene biosynthesis from Z,Z-farnesyl pyrophosphate in the wild tomato Solanum habrochaites.	The Plant cell 20090101
Protein farnesyltransferase-catalyzed isoprenoid transfer to peptide depends on lipid size and shape, not hydrophobicity.	Chembiochem : a European journal of chemical biology 20081124
Mechanisms of the action of zoledronic acid on human MG-63 osteosarcoma cells.	Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20081101
Isolation and characterization of the gene associated with geosmin production in cyanobacteria.	Environmental science & technology 20081101
Statins activate GATA-6 and induce differentiated vascular smooth muscle cells.	Biochemical and biophysical research communications 20081003
Simvastatin suppresses LPS-induced MMP-1 expression in U937 mononuclear cells by inhibiting protein isoprenylation-mediated ERK activation.	Journal of leukocyte biology 20081001
Overexpression of the lemon basil alpha-zingiberene synthase gene increases both mono- and sesquiterpene contents in tomato fruit.	The Plant journal : for cell and molecular biology 20081001
Initiation of rubber biosynthesis: In vitro comparisons of benzophenone-modified diphosphate analogues in three rubber-producing species.	Phytochemistry 20081001
Computational studies on biosynthetic carbocation rearrangements leading to sativene, cyclosativene, alpha-ylangene, and beta-ylangene.	The Journal of organic chemistry 20080905
Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92.	The Journal of biological chemistry 20080725
Quantitative determination of farnesyl and geranylgeranyl diphosphate levels in mammalian tissue.	Analytical biochemistry 20080715
Simvastatin inhibits central sympathetic outflow in heart failure by a nitric-oxide synthase mechanism.	The Journal of pharmacology and experimental therapeutics 20080701
Redirection of flux through the FPP branch-point in Saccharomyces cerevisiae by down-regulating squalene synthase.	Biotechnology and bioengineering 20080601
X-ray crystallographic studies of substrate binding to aristolochene synthase suggest a metal ion binding sequence for catalysis.	The Journal of biological chemistry 20080530
Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells.	Melanoma research 20080401
Statins inhibit proliferation and induce apoptosis in Barrett's esophageal adenocarcinoma cells.	The American journal of gastroenterology 20080401
Biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism.	Biochemistry 20080325
Design and structure-activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): tetramic, tetronic acids and dihydropyridin-2-ones.	Bioorganic & medicinal chemistry letters 20080315
Synthesis and biochemical evaluation of 3,7-disubstituted farnesyl diphosphate analogues.	The Journal of organic chemistry 20080307
A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.	Science (New York, N.Y.) 20080307
Isolation and functional characterization of a beta-eudesmol synthase, a new sesquiterpene synthase from Zingiber zerumbet Smith.	FEBS letters 20080305
Simvastatin antagonizes tumor necrosis factor-alpha inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway.	The Journal of endocrinology 20080301
Kinetic studies of Micrococcus luteus B-P 26 undecaprenyl diphosphate synthase reaction using 3-desmethyl allylic substrate analogs.	Bioscience, biotechnology, and biochemistry 20080301
Structural analysis of farnesyl pyrophosphate synthase from parasitic protozoa, a potential chemotherapeutic target.	Infectious disorders drug targets 20080301
A sesquiterpene distress signal transmitted by maize.	The Plant cell 20080201
A maize (E)-beta-caryophyllene synthase implicated in indirect defense responses against herbivores is not expressed in most American maize varieties.	The Plant cell 20080201
Geosmin biosynthesis. Mechanism of the fragmentation-rearrangement in the conversion of germacradienol to geosmin.	Journal of the American Chemical Society 20080116
Nitrogen-containing bisphosphonate, YM529/ONO-5920, inhibits macrophage inflammatory protein 1 alpha expression and secretion in mouse myeloma cells.	Cancer science 20080101
Simvastatin inhibits C-reactive protein-induced pro-inflammatory changes in endothelial cells by decreasing mevalonate pathway products.	Cardiology 20080101
Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway.	Journal of muscle research and cell motility 20080101
Farnesyl diphosphate analogues with omega-bioorthogonal azide and alkyne functional groups for protein farnesyl transferase-catalyzed ligation reactions.	The Journal of organic chemistry 20071123
Cloning and characterization of isoprenyl diphosphate synthases with farnesyl diphosphate and geranylgeranyl diphosphate synthase activity from Norway spruce (Picea abies) and their relation to induced oleoresin formation.	Phytochemistry 20071101
Farnesyl pyrophosphate is a novel transcriptional activator for a subset of nuclear hormone receptors.	Molecular endocrinology (Baltimore, Md.) 20071101
Computational studies of the farnesyltransferase ternary complex part II: the conformational activation of farnesyldiphosphate.	Biochemistry 20071030
Competitive inhibition of aristolochene synthase by phenyl-substituted farnesyl diphosphates: evidence of active site plasticity.	Organic & biomolecular chemistry 20071021
The farnesyl-diphosphate/geranylgeranyl-diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and a molecular target of bisphosphonates.	The Journal of biological chemistry 20071019
Aristolochene synthase-catalyzed cyclization of 2-fluorofarnesyl-diphosphate to 2-fluorogermacrene A.	Chembiochem : a European journal of chemical biology 20071015
Interception of the enzymatic conversion of farnesyl diphosphate to 5-epi-aristolochene by using a fluoro substrate analogue: 1-fluorogermacrene A from (2E,6Z)-6-fluorofarnesyl diphosphate.	Chembiochem : a European journal of chemical biology 20071015
Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity.	Cancer research 20071015
Selective modification of CaaX peptides with ortho-substituted anilinogeranyl lipids by protein farnesyl transferase: competitive substrates and potent inhibitors from a library of farnesyl diphosphate analogues.	Biochemistry 20071009
Protein farnesyl transferase target selectivity is dependent upon peptide stimulated product release.	Biochemistry 20071009
Atorvastatin decreases lipoprotein lipase and endothelial lipase expression in human THP-1 macrophages.	Journal of lipid research 20071001
The carboxyl-terminal region of the geranylgeranyl diphosphate synthase is indispensable for the stabilization of the region involved in substrate binding and catalysis.	Journal of biochemistry 20071001
Isoprenoid depletion by statins antagonizes cytokine-induced down-regulation of endothelial nitric oxide expression and increases NO synthase activity in human umbilical vein endothelial cells.	Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20070901
Induction of mitochondria-dependent apoptosis through the inhibition of mevalonate pathway in human breast cancer cells by YM529, a new third generation bisphosphonate.	Cancer letters 20070808
Control of juvenile hormone biosynthesis in Bombyx mori: cloning of the enzymes in the mevalonate pathway and assessment of their developmental expression in the corpora allata.	Insect biochemistry and molecular biology 20070801
Survivin down-regulation plays a crucial role in 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor-induced apoptosis in cancer.	The Journal of biological chemistry 20070706
Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation.	Stem cells (Dayton, Ohio) 20070701
Combinatorial modulation of protein prenylation.	ACS chemical biology 20070615
Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases.	Proceedings of the National Academy of Sciences of the United States of America 20070612
Kinetic characterization of squalene synthase from Trypanosoma cruzi: selective inhibition by quinuclidine derivatives.	Antimicrobial agents and chemotherapy 20070601
Short-chain prenyl diphosphate synthase that condenses isopentenyl diphosphate with dimethylallyl diphosphate in ispA null Escherichia coli strain lacking farnesyl diphosphate synthase.	Journal of bioscience and bioengineering 20070601
Metabolic engineering of sesquiterpene metabolism in yeast.	Biotechnology and bioengineering 20070501
Monoterpenoid biosynthesis in Saccharomyces cerevisiae.	FEMS yeast research 20070501
Atorvastatin inhibits angiotensin-converting enzyme induction in differentiating human macrophages.	American journal of physiology. Heart and circulatory physiology 20070401
Exploiting the substrate tolerance of farnesyltransferase for site-selective protein derivatization.	Chembiochem : a European journal of chemical biology 20070305
Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase.	Biochemical and biophysical research communications 20070223
X-ray crystal structure of aristolochene synthase from Aspergillus terreus and evolution of templates for the cyclization of farnesyl diphosphate.	Biochemistry 20070220
Unusual features of a recombinant apple alpha-farnesene synthase.	Phytochemistry 20070101
Tissue factor induction by aggregated LDL depends on LDL receptor-related protein expression (LRP1) and Rho A translocation in human vascular smooth muscle cells.	Cardiovascular research 20070101
Atorvastatin neutralizes the up-regulation of thrombospondin-1 induced by thrombin in human umbilical vein endothelial cells.	Endothelium : journal of endothelial cell research 20070101
Structure and reaction geometry of geranylgeranyl diphosphate synthase from Sinapis alba.	Biochemistry 20061226
Hydrophilic anilinogeranyl diphosphate prenyl analogues are Ras function inhibitors.	Biochemistry 20061226
Biochemical characterization of the decaprenyl diphosphate synthase of Rhodobacter sphaeroides for coenzyme Q10 production.	Applied microbiology and biotechnology 20061201
Farnesyl phosphates are endogenous ligands of lysophosphatidic acid receptors: inhibition of LPA GPCR and activation of PPARs.	Biochimica et biophysica acta 20061201
Direct observation of substrate-enzyme complexation by surface forces measurement.	Journal of the American Chemical Society 20061129
Characterization and tissue-specific expression of two lepidopteran farnesyl diphosphate synthase homologs: implications for the biosynthesis of ethyl-substituted juvenile hormones.	Proteins 20061115
Simvastatin inhibits the migration and adhesion of monocytic cells and disorganizes the cytoskeleton of activated endothelial cells.	European journal of pharmacology 20061024
The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding.	The Journal of biological chemistry 20060804
Geosmin biosynthesis in Streptomyces avermitilis. Molecular cloning, expression, and mechanistic study of the germacradienol/geosmin synthase.	The Journal of antibiotics 20060801
RhoA and p38 MAPK mediate apoptosis induced by cellular cholesterol depletion.	Apoptosis : an international journal on programmed cell death 20060701
Lovastatin-induced apoptosis in macrophages through the Rac1/Cdc42/JNK pathway.	Journal of immunology (Baltimore, Md. : 1950) 20060701
Geosmin biosynthesis. Streptomyces coelicolor germacradienol/germacrene D synthase converts farnesyl diphosphate to geosmin.	Journal of the American Chemical Society 20060628
Simvastatin decreases IL-6 and IL-8 production in epithelial cells.	Journal of dental research 20060601
Genome mining in Streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase.	Journal of the American Chemical Society 20060510
Theoretical studies on farnesyl cation cyclization: pathways to pentalenene.	Journal of the American Chemical Society 20060510
Cyclization mechanism of amorpha-4,11-diene synthase, a key enzyme in artemisinin biosynthesis.	Journal of natural products 20060501
Amorpha-4,11-diene synthase: mechanism and stereochemistry of the enzymatic cyclization of farnesyl diphosphate.	Archives of biochemistry and biophysics 20060415
How to evolve a silk purse from a sow's ear.	Nature chemical biology 20060401
Production of the artemisinin precursor amorpha-4,11-diene by engineered Saccharomyces cerevisiae.	Biotechnology letters 20060401
Convenient methods for the synthesis of P1-farnesyl-P2-indicator diphosphates.	Bioorganic & medicinal chemistry letters 20060315
Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids.	Journal of the American Chemical Society 20060308
A soluble form of phosphatase in Saccharomyces cerevisiae capable of converting farnesyl diphosphate into E,E-farnesol.	Applied biochemistry and biotechnology 20060201
Regulation of fatty acid synthesis by farnesyl pyrophosphate.	The Journal of biological chemistry 20051223
Interplay of isoprenoid and peptide substrate specificity in protein farnesyltransferase.	Biochemistry 20050823
Simvastatin inhibits NOR-1 expression induced by hyperlipemia by interfering with CREB activation.	Cardiovascular research 20050801
Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition: a role for RhoA in ABCA1-mediated cholesterol efflux.	The Journal of biological chemistry 20050610
Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis.	The Journal of biological chemistry 20050527
Directed library of anilinogeranyl analogues of farnesyl diphosphate via mixed solid- and solution-phase synthesis.	Organic letters 20050526
Cloning and expression of a farnesyl diphosphate synthase in Centella asiatica (L.) Urban.	Molecules and cells 20050430
Lovastatin-induced apoptosis in human melanoma cell lines.	Melanoma research 20050401
HMG-CoA reductase inhibition reduces monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated monocyte recruitment in vivo.	Circulation 20050322
Substrate and product specificities of cis-type undecaprenyl pyrophosphate synthase.	The Biochemical journal 20050215
Effect of pitavastatin on transactivation of human serum paraoxonase 1 gene.	Metabolism: clinical and experimental 20050201
Geranylgeranylated proteins are involved in the regulation of myeloma cell growth.	Clinical cancer research : an official journal of the American Association for Cancer Research 20050115
Simultaneous determination of farnesyl and geranylgeranyl pyrophosphate levels in cultured cells.	Analytical biochemistry 20050101
[Minodronic acid hydrate as a new therapeutic agent for osteoporosis].	Clinical calcium 20050101
Regulation of rubber biosynthetic rate and molecular weight in Hevea brasiliensis by metal cofactor.	Biomacromolecules 20050101
Computational and conformational evaluation of FTase alternative substrates: insight into a novel enzyme binding pocket.	Journal of chemical information and modeling 20050101
Tools to analyze protein farnesylation in cells.	Bioconjugate chemistry 20050101
A novel approach to prezizaane sesquiterpenes.	Chemistry & biodiversity 20041201
Synthesis and activity of fluorescent isoprenoid pyrophosphate analogues.	The Journal of organic chemistry 20041126
Statins inhibit in vitro calcification of human vascular smooth muscle cells induced by inflammatory mediators.	Journal of cellular biochemistry 20041115
Structure of 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase from Shewanella oneidensis at 1.6 A: identification of farnesyl pyrophosphate trapped in a hydrophobic cavity.	Acta crystallographica. Section D, Biological crystallography 20041101
Synthesis of acyloxymethyl ester prodrugs of the transferable protein farnesyl transferase substrate farnesyl methylenediphosphonate.	Bioorganic & medicinal chemistry letters 20041004
Dual role for phenylalanine 178 during catalysis by aristolochene synthase.	Chemical communications (Cambridge, England) 20040921
Glucose-potentiated chemotaxis in human vascular smooth muscle is dependent on cross-talk between the PI3K and MAPK signaling pathways.	Circulation research 20040820
Lysine beta311 of protein geranylgeranyltransferase type I partially replaces magnesium.	The Journal of biological chemistry 20040716
Differential effects of simvastatin on mesangial cells.	Kidney international 20040701
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (pravastatin) inhibits endothelial cell proliferation dependent on G1 cell cycle arrest.	Anti-cancer drugs 20040701
Simvastatin augments lipopolysaccharide-induced proinflammatory responses in macrophages by differential regulation of the c-Fos and c-Jun transcription factors.	Journal of immunology (Baltimore, Md. : 1950) 20040615
Atorvastatin completely inhibits VEGF-induced ACE upregulation in human endothelial cells.	American journal of physiology. Heart and circulatory physiology 20040601
Identification of a novel class of omega,E,E-farnesyl diphosphate synthase from Mycobacterium tuberculosis.	Journal of lipid research 20040601
Multisite inhibition by phenylacetate of PC-3 cell growth.	Anti-cancer drugs 20040601
Didehydrofarnesyl diphosphate: an intrinsically fluorescent inhibitor of protein farnesyltransferase.	Bioorganic & medicinal chemistry letters 20040503
HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis.	Journal of neurochemistry 20040401
Differential effects of prenyl pyrophosphates on the phosphatase activity of phosphotyrosyl protein phosphatase.	Journal of experimental zoology. Part A, Comparative experimental biology 20040401
Substrate binding mode and reaction mechanism of undecaprenyl pyrophosphate synthase deduced from crystallographic studies.	Protein science : a publication of the Protein Society 20040401
Isoprenoids: remarkable diversity of form and function.	Lipids 20040401
Statins inhibit osteoblast migration by inhibiting Rac-Akt signaling.	Biochemical and biophysical research communications 20040312
Mechanism and stereochemistry of the germacradienol/germacrene D synthase of Streptomyces coelicolor A3(2).	Journal of the American Chemical Society 20040310
Characterization of botryococcene synthase enzyme activity, a squalene synthase-like activity from the green microalga Botryococcus braunii, Race B.	Archives of biochemistry and biophysics 20040201
[The role of mevalonate pathway in osteogenic cells].	Nihon rinsho. Japanese journal of clinical medicine 20040201
Lovastatin and mevastatin reduce basal and cytokine-stimulated production of prostaglandins from rat microglial cells in vitro: evidence for a mechanism unrelated to the inhibition of hydroxy-methyl-glutaryl CoA reductase.	Neuroscience letters 20040109
Staphylococcus aureus mevalonate kinase: isolation and characterization of an enzyme of the isoprenoid biosynthetic pathway.	Journal of bacteriology 20040101
Cerivastatin-induced apoptosis of human aortic smooth muscle cells through partial inhibition of basal activation of extracellular signal-regulated kinases.	Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 20040101
Fluvastatin reduces renal fibroblast proliferation and production of type III collagen: therapeutic implications for tubulointerstitial fibrosis.	Nephron. Experimental nephrology 20040101
Mutagenesis studies of protein farnesyltransferase implicate aspartate beta 352 as a magnesium ligand.	The Journal of biological chemistry 20031219
Identification of the active conformation and the importance of length of the flexible loop 72-83 in regulating the conformational change of undecaprenyl pyrophosphate synthase.	Biochemistry 20031216
Statins induce suppressor of cytokine signaling-3 in macrophages.	FEBS letters 20031204
Synthesis of aniline-type analogues of farnesyl diphosphate and their biological assays for prenyl protein transferase inhibitory activity.	Farmaco (Societa chimica italiana : 1989) 20031201
Terpenoid metabolism in wild-type and transgenic Arabidopsis plants.	The Plant cell 20031201
Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho.	Science (New York, N.Y.) 20031114
Simvastatin modulates expression of the PON1 gene and increases serum paraoxonase: a role for sterol regulatory element-binding protein-2.	Arteriosclerosis, thrombosis, and vascular biology 20031101
Protein farnesyltransferase inhibitors interfere with farnesyl diphosphate binding by rubber transferase.	European journal of biochemistry 20031001
All hydrophobic HMG-CoA reductase inhibitors induce apoptotic death in rat pulmonary vein endothelial cells.	Atherosclerosis 20031001
Stabilisation of eudesmane cation by tryptophan 334 during aristolochene synthase catalysis.	Chemical communications (Cambridge, England) 20030907
Farnesyl pyrophosphate promotes and is essential for the binding of RACK1 with beta-tubulin.	Journal of experimental zoology. Part A, Comparative experimental biology 20030801
Effects of peroxisome proliferators gemfibrozil and clofibrate on syntheses of dolichol and cholesterol in rat liver.	Journal of biochemistry 20030801
A quantitative structure-activity relationship and pharmacophore modeling investigation of aryl-X and heterocyclic bisphosphonates as bone resorption agents.	Journal of medicinal chemistry 20030703
Evidence for differential folding of farnesyl pyrophosphate in the active site of aristolochene synthase: a single-point mutation converts aristolochene synthase into an (E)-beta-farnesene synthase.	Biochemistry 20030701
Detection of farnesyl diphosphate accumulation in yeast ERG9 mutants.	Analytical biochemistry 20030615
Biosynthesis of anthecotuloide, an irregular sesquiterpene lactone from Anthemis cotula L. (Asteraceae) via a non-farnesyl diphosphate route.	Organic & biomolecular chemistry 20030507
From pure FPP to mixed FPP and CAAX competitive inhibitors of farnesyl protein transferase.	Bioorganic & medicinal chemistry letters 20030417
Biochemical and structural studies with prenyl diphosphate analogues provide insights into isoprenoid recognition by protein farnesyl transferase.	Biochemistry 20030408
Synthesis and antimicrobial evaluation of farnesyl diphosphate mimetics.	Bioorganic chemistry 20030201
Effects of prenyl pyrophosphates on the binding of PKCgamma with RACK1.	Journal of experimental zoology. Part A, Comparative experimental biology 20030101
Cholesterol biosynthesis and regulation: role of peroxisomes.	Advances in experimental medicine and biology 20030101
Synthesis and application of a fluorescent substrate analogue to study ligand interactions for undecaprenyl pyrophosphate synthase.	Journal of the American Chemical Society 20021225
Feeding of [5,5-2H(2)]-1-desoxy-D-xylulose and [4,4,6,6,6-2H(5)]-mevalolactone to a geosmin-producing Streptomyces sp. and Fossombronia pusilla.	Phytochemistry 20021201
Cerivastatin, a HMG-CoA reductase inhibitor, reduces plasminogen activator inhibitor-1 (PAI-1) expression in endothelial cells by down-regulation of cellular signaling and the inhibition of PAI-1 promoter activity.	Japanese journal of pharmacology 20021201
Cerivastatin potentiates nitric oxide release and enos expression through inhibition of isoprenoids synthesis.	Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20021201
Isoprenoids influence expression of Ras and Ras-related proteins.	Biochemistry 20021119
Effects of prenyl pyrophosphates on the binding of S-Ras proteins with KSR.	The Journal of experimental zoology 20021101
Geranylgeranyl pyrophosphate counteracts the cataractogenic effect of lovastatin on cultured rat lenses.	Experimental eye research 20021101
Tyrosine 92 of aristolochene synthase directs cyclisation of farnesyl pyrophosphate.	Chemical communications (Cambridge, England) 20021021
Germacrene A is a product of the aristolochene synthase-mediated conversion of farnesylpyrophosphate to aristolochene.	Journal of the American Chemical Society 20021002
Synthesis of novel 4,1-benzoxazepine derivatives as squalene synthase inhibitors and their inhibition of cholesterol synthesis.	Journal of medicinal chemistry 20020926
Incadronate disodium inhibits advanced glycation end products-induced angiogenesis in vitro.	Biochemical and biophysical research communications 20020920
Synthesis of 7-substituted farnesyl diphosphate analogues.	Organic letters 20020905
Genetics of isoprenoid biosynthesis in Paracoccus zeaxanthinifaciens.	Gene 20020904
Central role of peroxisomes in isoprenoid biosynthesis.	Progress in lipid research 20020901
Inhibition of squalene synthase and squalene epoxidase in tobacco cells triggers an up-regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase.	Plant physiology 20020901
Alpha-phosphono lactone analogues of farnesyl pyrophosphate: an asymmetric synthesis via ring-closing metathesis.	The Journal of organic chemistry 20020809
[New therapeutic targets and strategies in lung cancer].	Archivos de bronconeumologia 20020801
Recombinant squalene synthase. Synthesis of non-head-to-tail isoprenoids in the absence of NADPH.	Journal of the American Chemical Society 20020731
Recombinant squalene synthase. A mechanism for the rearrangement of presqualene diphosphate to squalene.	Journal of the American Chemical Society 20020731
Photoaffinity analogues of farnesyl pyrophosphate transferable by protein farnesyl transferase.	Journal of the American Chemical Society 20020717
Alteration of product formation by directed mutagenesis and truncation of the multiple-product sesquiterpene synthases delta-selinene synthase and gamma-humulene synthase.	Archives of biochemistry and biophysics 20020601
Interaction of yeast Rab geranylgeranyl transferase with its protein and lipid substrates.	Biochemistry 20020528
Aromatic farnesyl diphosphate analogues: vinyl triflate-mediated synthesis and preliminary enzymatic evaluation.	Bioorganic & medicinal chemistry letters 20020520
Protein farnesyltransferase inhibitors.	Current medicinal chemistry 20020501
Cerivastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase, inhibits endothelial cell proliferation induced by angiogenic factors in vitro and angiogenesis in in vivo models.	Arteriosclerosis, thrombosis, and vascular biology 20020401
3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation.	Atherosclerosis 20020301
Insight into the activation mechanism of Escherichia coli octaprenyl pyrophosphate synthase derived from pre-steady-state kinetic analysis.	Biochimica et biophysica acta 20020131
Complex regulation of ABA biosynthesis in plants.	Trends in plant science 20020101
[Current state of carotenoid biosynthesis in chloroplasts of eucaryotes].	Zhurnal obshchei biologii 20020101
The in vivo synthesis of plant sesquiterpenes by Escherichia coli.	Biotechnology and bioengineering 20011205
GTPase stimulation in shrimp Ras(Q(61)K) with geranylgeranyl pyrophosphate but not mammalian GAP.	The Journal of experimental zoology 20011101
Protein farnesyltransferase isoprenoid substrate discrimination is dependent on isoprene double bonds and branched methyl groups.	Biochemistry 20011016
Synthesis of (S)-isoprenoid thiodiphosphates as substrates and inhibitors.	The Journal of organic chemistry 20011005
Functional properties of diapophytoene and related desaturases of C(30) and C(40) carotenoid biosynthetic pathways.	Biochimica et biophysica acta 20010928
Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase.	The Journal of biological chemistry 20010907
Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells.	Leukemia 20010901
Lipophilic statins can be osteogenic by promoting osteoblastic calcification in a Cbfa1- and BMP-2-independent manner.	Methods and findings in experimental and clinical pharmacology 20010901
Rho-dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins).	British journal of pharmacology 20010801
Characterization of phosphoantigens by high-performance anion-exchange chromatography-electrospray ionization ion trap mass spectrometry and nanoelectrospray ionization ion trap mass spectrometry.	Analytical chemistry 20010801
Partial characterization of farnesyl and geranylgeranyl diphosphatases induced in rice seedlings by UV-C irradiation.	Plant & cell physiology 20010801
Dominant negative farnesyltransferase alpha-subunit inhibits insulin mitogenic effects.	Biochemical and biophysical research communications 20010713
Structural features of nonpeptide prenyl pyrophosphates that determine their antigenicity for human gamma delta T cells.	Journal of immunology (Baltimore, Md. : 1950) 20010701
Statins suppress THP-1 cell migration and secretion of matrix metalloproteinase 9 by inhibiting geranylgeranylation.	Journal of leukocyte biology 20010601
Synthesis of farnesyl diphosphate analogues containing ether-linked photoactive benzophenones and their application in studies of protein prenyltransferases.	The Journal of organic chemistry 20010518
Labeling patterns of chloroplastidic isoprenoids in cultured cells of liverwort Ptychanthus striatus.	Bioscience, biotechnology, and biochemistry 20010501
Inhibition of endothelial cell migration by cerivastatin, an HMG-CoA reductase inhibitor: contribution to its anti-angiogenic effect.	FEBS letters 20010427
The cyclization of farnesyl diphosphate and nerolidyl diphosphate by a purified recombinant delta-cadinene synthase.	Plant physiology 20010401
Partial purification and characterization of the short-chain prenyltransferases, gernayl diphospate synthase and farnesyl diphosphate synthase, from Abies grandis (grand fir).	Archives of biochemistry and biophysics 20010215
Study on the biosynthesis of dolichol in yeast: recognition of the prenyl chain length in polyprenol reduction.	Journal of biochemistry 20010201
Lovastatin induces apoptosis of spontaneously immortalized rat brain neuroblasts: involvement of nonsterol isoprenoid biosynthesis inhibition.	Molecular and cellular neurosciences 20010201
Cracking down on caveolin: role of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in modulating edothelial cell nitric oxide production.	Circulation 20010102
Arglabin-DMA, a plant derived sesquiterpene, inhibits farnesyltransferase.	Oncology reports 20010101
Involvement of Rho GTPases in the transcriptional inhibition of preproendothelin-1 gene expression by simvastatin in vascular endothelial cells.	Circulation research 20000929
Simvastatin modulates cytokine-mediated endothelial cell adhesion molecule induction: involvement of an inhibitory G protein.	Journal of immunology (Baltimore, Md. : 1950) 20000901
The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures.	Structure (London, England : 1993) 20000215
Farnesol is utilized for isoprenoid biosynthesis in plant cells via farnesyl pyrophosphate formed by successive monophosphorylation reactions.	Proceedings of the National Academy of Sciences of the United States of America 19991109
Cloning, expression, and characterization of epi-cedrol synthase, a sesquiterpene cyclase from Artemisia annua L.	Archives of biochemistry and biophysics 19990915
Spider mite-induced (3S)-(E)-nerolidol synthase activity in cucumber and lima bean. The first dedicated step in acyclic C11-homoterpene biosynthesis.	Plant physiology 19990901
Lovastatin augments apoptosis induced by chemotherapeutic agents in colon cancer cells.	Clinical cancer research : an official journal of the American Association for Cancer Research 19990801
Isolation, characterization, and mechanistic studies of (-)-alpha-gurjunene synthase from Solidago canadensis.	Archives of biochemistry and biophysics 19990415
Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue.	Biochemistry 19981124
Truncation of human squalene synthase yields active, crystallizable protein.	Archives of biochemistry and biophysics 19980215
Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways.	Journal of lipid research 19971101
Identification of catalytic residues in human mevalonate kinase.	The Journal of biological chemistry 19971010
Structural basis for cyclic terpene biosynthesis by tobacco 5-epi-aristolochene synthase.	Science (New York, N.Y.) 19970919
Natural and synthetic non-peptide antigens recognized by human gamma delta T cells.	Nature 19950511
Expression, purification, and characterization of the human squalene synthase: use of yeast and baculoviral systems.	Archives of biochemistry and biophysics 19950201
Solubilization, purification, and characterization of a truncated form of rat hepatic squalene synthetase.	The Journal of biological chemistry 19920425
Purification and regulation of mevalonate kinase from rat liver.	The Journal of biological chemistry 19900205
The biosynthesis of dehydrodolichyl phosphates by rat liver microsomes.	Biochimica et biophysica acta 19890403
Squalene synthetase.	Methods in enzymology 19850101

Heterologous expression of pentalenene synthase (PSS) from Streptomyces UC5319 in Xanthophyllomyces dendrorhous.

Journal of biotechnology 20121031

2C-Methyl-d-erythritol 4-phosphate enhances and sustains cyclodiphosphate synthase IspF activity.

ACS chemical biology 20121019

Functional analysis and molecular docking identify two active short-chain prenyltransferases in the green peach aphid, Myzus persicae.

Archives of insect biochemistry and physiology 20121001

Identification and characterization of a cis,trans-mixed heptaprenyl diphosphate synthase from Arabidopsis thaliana.

The FEBS journal 20121001

Chemoenzymatic synthesis of an isoprenoid phosphate tool for the analysis of complex bacterial oligosaccharide biosynthesis.

Carbohydrate research 20121001

Structures, mechanisms and inhibitors of undecaprenyl diphosphate synthase: a cis-prenyltransferase for bacterial peptidoglycan biosynthesis.

Bioorganic chemistry 20120801

Brain isoprenoids farnesyl pyrophosphate and geranylgeranyl pyrophosphate are increased in aged mice.

Molecular neurobiology 20120801

Development of petri net-based dynamic model for improved production of farnesyl pyrophosphate by integrating mevalonate and methylerythritol phosphate pathways in yeast.

Applied biochemistry and biotechnology 20120701

Simvastatin decreases invasiveness of human endometrial stromal cells.

Biology of reproduction 20120701

Farnesyl pyrophosphate is an endogenous antagonist to ADP-stimulated P2Y₁₂ receptor-mediated platelet aggregation.

Thrombosis and haemostasis 20120701

Investigating conservation of the albaflavenone biosynthetic pathway and CYP170 bifunctionality in streptomycetes.

The FEBS journal 20120501

A 1,6-ring closure mechanism for (+)-δ-cadinene synthase?

Journal of the American Chemical Society 20120404

NMR for direct determination of K(m) and V(max) of enzyme reactions based on the Lambert W function-analysis of progress curves.

Biochimica et biophysica acta 20120301

Identification, functional characterization, and regulation of the enzyme responsible for floral (E)-nerolidol biosynthesis in kiwifruit (Actinidia chinensis).

Journal of experimental botany 20120301

Nonradioactive assay for detecting isoprenyl diphosphate synthase activity in crude plant extracts using liquid chromatography coupled with tandem mass spectrometry.

Analytical biochemistry 20120301

Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation.

Neuroscience 20120127

Simvastatin reduces steroidogenesis by inhibiting Cyp17a1 gene expression in rat ovarian theca-interstitial cells.

Biology of reproduction 20120101

Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity.

Natural product reports 20120101

Steady-state kinetic characterization of sesquiterpene synthases by gas chromatography-mass spectroscopy.

Methods in enzymology 20120101

Quantitative proteomic analysis revealed lovastatin-induced perturbation of cellular pathways in HL-60 cells.

Journal of proteome research 20111202

Induction of isoprenyl diphosphate synthases, plant hormones and defense signalling genes correlates with traumatic resin duct formation in Norway spruce (Picea abies).

Plant molecular biology 20111201

Subcellular evidence for the involvement of peroxisomes in plant isoprenoid biosynthesis.

Plant signaling & behavior 20111201

Computational identification of sweet wormwood (Artemisia annua) microRNA and their mRNA targets.

Genomics, proteomics & bioinformatics 20111201

A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro.

Journal of lipid research 20111101

Resveratrol inhibits the mevalonate pathway and potentiates the antiproliferative effects of simvastatin in rat theca-interstitial cells.

Fertility and sterility 20111101

Identification of bottlenecks in Escherichia coli engineered for the production of CoQ(10).

Metabolic engineering 20111101

Protein prenylation contributes to the effects of LPS on EFS-induced responses in human isolated bronchi.

American journal of respiratory cell and molecular biology 20111001

Pleiotropic effects of a schweinfurthin on isoprenoid homeostasis.

Lipids 20111001

Metabolically regulated endoplasmic reticulum-associated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase: evidence for requirement of a geranylgeranylated protein.

The Journal of biological chemistry 20110916

Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist.

The Biochemical journal 20110815

Isoprenoid is a perfect fit for fat factor.

The Biochemical journal 20110815

Characterization of a novel sesquiterpene cyclase involved in (+)-caryolan-1-ol biosynthesis in Streptomyces griseus.

The Journal of biological chemistry 20110812

Effects of farnesyl pyrophosphate accumulation on calvarial osteoblast differentiation.

Endocrinology 20110801

New synthetic methodology for the construction of 7-substituted farnesyl diphosphate analogs.

Organic letters 20110715

Isopentenyl pyrophosphate is a novel antinociceptive substance that inhibits TRPV3 and TRPA1 ion channels.

Pain 20110501

Geranylgeranylation facilitates proteasomal degradation of rho G-proteins in human trabecular meshwork cells.

Investigative ophthalmology & visual science 20110325

Cloning and characterization of an Armillaria gallica cDNA encoding protoilludene synthase, which catalyzes the first committed step in the synthesis of antimicrobial melleolides.

The Journal of biological chemistry 20110304

Crystal structure of heterodimeric hexaprenyl diphosphate synthase from Micrococcus luteus B-P 26 reveals that the small subunit is directly involved in the product chain length regulation.

The Journal of biological chemistry 20110204

Rv0989c encodes a novel (E)-geranyl diphosphate synthase facilitating decaprenyl diphosphate biosynthesis in Mycobacterium tuberculosis.

FEBS letters 20110204

Genome mining in Streptomyces clavuligerus: expression and biochemical characterization of two new cryptic sesquiterpene synthases.

Chemistry & biology 20110128

Geranylgeranyl-pyrophosphate regulates secretion of pentraxin 3 and monocyte chemoattractant protein-1 from rheumatoid fibroblast-like synoviocytes in distinct manners.

Clinical and experimental rheumatology 20110101

Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts.

Respiratory research 20110101

Nuclear receptor engineering based on novel structure activity relationships revealed by farnesyl pyrophosphate.

Protein engineering, design & selection : PEDS 20101101

Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway.

Biotechnology and bioengineering 20101015

A rapid and sensitive assay for determining human brain levels of farnesyl-(FPP) and geranylgeranylpyrophosphate (GGPP) and transferase activities using UHPLC-MS/MS.

Analytical and bioanalytical chemistry 20101001

Mechanism of cis-prenyltransferase reaction probed by substrate analogues.

Biochemical and biophysical research communications 20101001

Enantioselective inhibition of squalene synthase by aziridine analogues of presqualene diphosphate.

The Journal of organic chemistry 20100716

Genome mining in Streptomyces avermitilis: cloning and characterization of SAV_76, the synthase for a new sesquiterpene, avermitilol.

Journal of the American Chemical Society 20100707

Pitavastatin strengthens the barrier integrity in primary cultures of rat brain endothelial cells.

Cellular and molecular neurobiology 20100701

Total synthesis: towards artificial terpene cyclases.

Nature chemistry 20100701

Anticancer activity of novel unnatural synthetic isoprenoids.

Anticancer research 20100701

Farnesyl pyrophosphate is a novel pain-producing molecule via specific activation of TRPV3.

The Journal of biological chemistry 20100618

Modulation of cholesterol, farnesylpyrophosphate, and geranylgeranylpyrophosphate in neuroblastoma SH-SY5Y-APP695 cells: impact on amyloid beta-protein production.

Molecular neurobiology 20100601

Sesquiterpene synthases Cop4 and Cop6 from Coprinus cinereus: catalytic promiscuity and cyclization of farnesyl pyrophosphate geometric isomers.

Chembiochem : a European journal of chemical biology 20100517

Lipophilic but not hydrophilic statins selectively induce cell death in gynaecological cancers expressing high levels of HMGCoA reductase.

Journal of cellular and molecular medicine 20100501

Enhancement of farnesyl diphosphate pool as direct precursor of sesquiterpenes through metabolic engineering of the mevalonate pathway in Saccharomyces cerevisiae.

Biotechnology and bioengineering 20100501

Functional characterization of the atypical integral membrane lipid phosphatase PDP1/PPAPDC2 identifies a pathway for interconversion of isoprenols and isoprenoid phosphates in mammalian cells.

The Journal of biological chemistry 20100430

Farnesyl diphosphate synthase attenuates paclitaxel-induced apoptotic cell death in human glioblastoma U87MG cells.

Neuroscience letters 20100426

Bisabolyl-derived sesquiterpenes from tobacco 5-epi-aristolochene synthase-catalyzed cyclization of (2Z,6E)-farnesyl diphosphate.

Journal of the American Chemical Society 20100331

Doubly deuterium-labeled patchouli alcohol from cyclization of singly labeled [2-(2)H(1)]farnesyl diphosphate catalyzed by recombinant patchoulol synthase.

Journal of the American Chemical Society 20100310

Differential activities of thalidomide and isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells.

Leukemia research 20100301

Geranylgeranyl diphosphate synthase genes in entomopathogenic fungi.

Applied microbiology and biotechnology 20100201

Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study.

Phytochemistry 20100201

A bifunctional geranyl and geranylgeranyl diphosphate synthase is involved in terpene oleoresin formation in Picea abies.

Plant physiology 20100201

In vitro synthesis of high molecular weight rubber by Hevea small rubber particles.

Journal of bioscience and bioengineering 20100201

Stabilization and translocation of p53 to mitochondria is linked to Bax translocation to mitochondria in simvastatin-induced apoptosis.

Biochemical and biophysical research communications 20100122

Farnesyl pyrophosphate inhibits epithelialization and wound healing through the glucocorticoid receptor.

The Journal of biological chemistry 20100115

Towards the synthesis of bisubstrate inhibitors of protein farnesyltransferase: Synthesis and biological evaluation of new farnesylpyrophosphate analogues.

Bioorganic & medicinal chemistry 20100115

Synthesis, properties, and applications of diazotrifluropropanoyl-containing photoactive analogs of farnesyl diphosphate containing modified linkages for enhanced stability.

Chemical biology & drug design 20100101

Distribution of endogenous farnesyl pyrophosphate and four species of lysophosphatidic acid in rodent brain.

International journal of molecular sciences 20100101

Crystal structure of albaflavenone monooxygenase containing a moonlighting terpene synthase active site.

The Journal of biological chemistry 20091225

Geranylgeranyl pyrophosphate is a potent regulator of HRD-dependent 3-Hydroxy-3-methylglutaryl-CoA reductase degradation in yeast.

The Journal of biological chemistry 20091218

Role of isoprenylation in simvastatin-induced inhibition of ovarian theca-interstitial growth in the rat.

Biology of reproduction 20091101

Quantitative determination of geranyl diphosphate levels in cultured human cells.

Lipids 20091101

Modes of inactivation of trichodiene synthase by a cyclopropane-containing farnesyldiphosphate analog.

Organic & biomolecular chemistry 20091007

Novel approaches and achievements in biosynthesis of functional isoprenoids in Escherichia coli.

Applied microbiology and biotechnology 20091001

P2Y5 is a G(alpha)i, G(alpha)12/13 G protein-coupled receptor activated by lysophosphatidic acid that reduces intestinal cell adhesion.

American journal of physiology. Gastrointestinal and liver physiology 20091001

Structural features conferring dual geranyl/farnesyl diphosphate synthase activity to an aphid prenyltransferase.

Insect biochemistry and molecular biology 20091001

Orphan endogenous lipids and orphan GPCRs: a good match.

Prostaglandins & other lipid mediators 20090901

Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases Potential relationship with the effect of bisphosphonates on osteoclasts.

Biochemical pharmacology 20090815

Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients.

Neurobiology of disease 20090801

Synthesis of imidazole-containing analogues of farnesyl pyrophosphate and evaluation of their biological activity on protein farnesyltransferase.

Journal of enzyme inhibition and medicinal chemistry 20090801

A versatile photoactivatable probe designed to label the diphosphate binding site of farnesyl diphosphate utilizing enzymes.

Bioorganic & medicinal chemistry 20090701

Biosynthesis of the sesquiterpene botrydial in Botrytis cinerea. Mechanism and stereochemistry of the enzymatic formation of presilphiperfolan-8beta-ol.

Journal of the American Chemical Society 20090624

Cholesterol biosynthesis modulation regulates dengue viral replication.

Virology 20090620

Statins induce apoptosis in ovarian cancer cells through activation of JNK and enhancement of Bim expression.

Cancer chemotherapy and pharmacology 20090501

Cloning and characterization of a squalene synthase gene from a petroleum plant, Euphorbia tirucalli L.

Planta 20090501

Simvastatin inhibits induction of matrix metalloproteinase-9 in rat alveolar macrophages exposed to cigarette smoke extract.

Experimental & molecular medicine 20090430

Global gene regulation by Fusarium transcription factors Tri6 and Tri10 reveals adaptations for toxin biosynthesis.

Molecular microbiology 20090401

Lysophosphatidylcholine increases Na+/Ca2+ exchanger expression via RhoB-geranylgeranylation in H9c2 cells.

Journal of pharmacological sciences 20090401

6- and 14-Fluoro farnesyl diphosphate: mechanistic probes for the reaction catalysed by aristolochene synthase.

Organic & biomolecular chemistry 20090307

An insect farnesyl phosphatase homologous to the N-terminal domain of soluble epoxide hydrolase.

Biochemical and biophysical research communications 20090227

Different reaction mechanisms for cis- and trans-prenyltransferases.

Biochemical and biophysical research communications 20090206

Role for protein geranylgeranylation in adult T-cell leukemia cell survival.

Experimental cell research 20090115

A novel pathway for sesquiterpene biosynthesis from Z,Z-farnesyl pyrophosphate in the wild tomato Solanum habrochaites.

The Plant cell 20090101

Protein farnesyltransferase-catalyzed isoprenoid transfer to peptide depends on lipid size and shape, not hydrophobicity.

Chembiochem : a European journal of chemical biology 20081124

Mechanisms of the action of zoledronic acid on human MG-63 osteosarcoma cells.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20081101

Isolation and characterization of the gene associated with geosmin production in cyanobacteria.

Environmental science & technology 20081101

Statins activate GATA-6 and induce differentiated vascular smooth muscle cells.

Biochemical and biophysical research communications 20081003

Simvastatin suppresses LPS-induced MMP-1 expression in U937 mononuclear cells by inhibiting protein isoprenylation-mediated ERK activation.

Journal of leukocyte biology 20081001

Overexpression of the lemon basil alpha-zingiberene synthase gene increases both mono- and sesquiterpene contents in tomato fruit.

The Plant journal : for cell and molecular biology 20081001

Initiation of rubber biosynthesis: In vitro comparisons of benzophenone-modified diphosphate analogues in three rubber-producing species.

Phytochemistry 20081001

Computational studies on biosynthetic carbocation rearrangements leading to sativene, cyclosativene, alpha-ylangene, and beta-ylangene.

The Journal of organic chemistry 20080905

Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92.

The Journal of biological chemistry 20080725

Quantitative determination of farnesyl and geranylgeranyl diphosphate levels in mammalian tissue.

Analytical biochemistry 20080715

Simvastatin inhibits central sympathetic outflow in heart failure by a nitric-oxide synthase mechanism.

The Journal of pharmacology and experimental therapeutics 20080701

Redirection of flux through the FPP branch-point in Saccharomyces cerevisiae by down-regulating squalene synthase.

Biotechnology and bioengineering 20080601

X-ray crystallographic studies of substrate binding to aristolochene synthase suggest a metal ion binding sequence for catalysis.

The Journal of biological chemistry 20080530

Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells.

Melanoma research 20080401

Statins inhibit proliferation and induce apoptosis in Barrett's esophageal adenocarcinoma cells.

The American journal of gastroenterology 20080401

Biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism.

Biochemistry 20080325

Design and structure-activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): tetramic, tetronic acids and dihydropyridin-2-ones.

Bioorganic & medicinal chemistry letters 20080315

Synthesis and biochemical evaluation of 3,7-disubstituted farnesyl diphosphate analogues.

The Journal of organic chemistry 20080307

A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.

Science (New York, N.Y.) 20080307

Isolation and functional characterization of a beta-eudesmol synthase, a new sesquiterpene synthase from Zingiber zerumbet Smith.

FEBS letters 20080305

Simvastatin antagonizes tumor necrosis factor-alpha inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway.

The Journal of endocrinology 20080301

Kinetic studies of Micrococcus luteus B-P 26 undecaprenyl diphosphate synthase reaction using 3-desmethyl allylic substrate analogs.

Bioscience, biotechnology, and biochemistry 20080301

Structural analysis of farnesyl pyrophosphate synthase from parasitic protozoa, a potential chemotherapeutic target.

Infectious disorders drug targets 20080301

A sesquiterpene distress signal transmitted by maize.

The Plant cell 20080201

A maize (E)-beta-caryophyllene synthase implicated in indirect defense responses against herbivores is not expressed in most American maize varieties.

The Plant cell 20080201

Geosmin biosynthesis. Mechanism of the fragmentation-rearrangement in the conversion of germacradienol to geosmin.

Journal of the American Chemical Society 20080116

Nitrogen-containing bisphosphonate, YM529/ONO-5920, inhibits macrophage inflammatory protein 1 alpha expression and secretion in mouse myeloma cells.

Cancer science 20080101

Simvastatin inhibits C-reactive protein-induced pro-inflammatory changes in endothelial cells by decreasing mevalonate pathway products.

Cardiology 20080101

Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway.

Journal of muscle research and cell motility 20080101

Farnesyl diphosphate analogues with omega-bioorthogonal azide and alkyne functional groups for protein farnesyl transferase-catalyzed ligation reactions.

The Journal of organic chemistry 20071123

Cloning and characterization of isoprenyl diphosphate synthases with farnesyl diphosphate and geranylgeranyl diphosphate synthase activity from Norway spruce (Picea abies) and their relation to induced oleoresin formation.

Phytochemistry 20071101

Farnesyl pyrophosphate is a novel transcriptional activator for a subset of nuclear hormone receptors.

Molecular endocrinology (Baltimore, Md.) 20071101

Computational studies of the farnesyltransferase ternary complex part II: the conformational activation of farnesyldiphosphate.

Biochemistry 20071030

Competitive inhibition of aristolochene synthase by phenyl-substituted farnesyl diphosphates: evidence of active site plasticity.

Organic & biomolecular chemistry 20071021

The farnesyl-diphosphate/geranylgeranyl-diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and a molecular target of bisphosphonates.

The Journal of biological chemistry 20071019

Aristolochene synthase-catalyzed cyclization of 2-fluorofarnesyl-diphosphate to 2-fluorogermacrene A.

Chembiochem : a European journal of chemical biology 20071015

Interception of the enzymatic conversion of farnesyl diphosphate to 5-epi-aristolochene by using a fluoro substrate analogue: 1-fluorogermacrene A from (2E,6Z)-6-fluorofarnesyl diphosphate.

Chembiochem : a European journal of chemical biology 20071015

Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity.

Cancer research 20071015

Selective modification of CaaX peptides with ortho-substituted anilinogeranyl lipids by protein farnesyl transferase: competitive substrates and potent inhibitors from a library of farnesyl diphosphate analogues.

Biochemistry 20071009

Protein farnesyl transferase target selectivity is dependent upon peptide stimulated product release.

Biochemistry 20071009

Atorvastatin decreases lipoprotein lipase and endothelial lipase expression in human THP-1 macrophages.

Journal of lipid research 20071001

The carboxyl-terminal region of the geranylgeranyl diphosphate synthase is indispensable for the stabilization of the region involved in substrate binding and catalysis.

Journal of biochemistry 20071001

Isoprenoid depletion by statins antagonizes cytokine-induced down-regulation of endothelial nitric oxide expression and increases NO synthase activity in human umbilical vein endothelial cells.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20070901

Induction of mitochondria-dependent apoptosis through the inhibition of mevalonate pathway in human breast cancer cells by YM529, a new third generation bisphosphonate.

Cancer letters 20070808

Control of juvenile hormone biosynthesis in Bombyx mori: cloning of the enzymes in the mevalonate pathway and assessment of their developmental expression in the corpora allata.

Insect biochemistry and molecular biology 20070801

Survivin down-regulation plays a crucial role in 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor-induced apoptosis in cancer.

The Journal of biological chemistry 20070706

Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation.

Stem cells (Dayton, Ohio) 20070701

Combinatorial modulation of protein prenylation.

ACS chemical biology 20070615

Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases.

Proceedings of the National Academy of Sciences of the United States of America 20070612

Kinetic characterization of squalene synthase from Trypanosoma cruzi: selective inhibition by quinuclidine derivatives.

Antimicrobial agents and chemotherapy 20070601

Short-chain prenyl diphosphate synthase that condenses isopentenyl diphosphate with dimethylallyl diphosphate in ispA null Escherichia coli strain lacking farnesyl diphosphate synthase.

Journal of bioscience and bioengineering 20070601

Metabolic engineering of sesquiterpene metabolism in yeast.

Biotechnology and bioengineering 20070501

Monoterpenoid biosynthesis in Saccharomyces cerevisiae.

FEMS yeast research 20070501

Atorvastatin inhibits angiotensin-converting enzyme induction in differentiating human macrophages.

American journal of physiology. Heart and circulatory physiology 20070401

Exploiting the substrate tolerance of farnesyltransferase for site-selective protein derivatization.

Chembiochem : a European journal of chemical biology 20070305

Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase.

Biochemical and biophysical research communications 20070223

X-ray crystal structure of aristolochene synthase from Aspergillus terreus and evolution of templates for the cyclization of farnesyl diphosphate.

Biochemistry 20070220

Unusual features of a recombinant apple alpha-farnesene synthase.

Phytochemistry 20070101

Tissue factor induction by aggregated LDL depends on LDL receptor-related protein expression (LRP1) and Rho A translocation in human vascular smooth muscle cells.

Cardiovascular research 20070101

Atorvastatin neutralizes the up-regulation of thrombospondin-1 induced by thrombin in human umbilical vein endothelial cells.

Endothelium : journal of endothelial cell research 20070101

Structure and reaction geometry of geranylgeranyl diphosphate synthase from Sinapis alba.

Biochemistry 20061226

Hydrophilic anilinogeranyl diphosphate prenyl analogues are Ras function inhibitors.

Biochemistry 20061226

Biochemical characterization of the decaprenyl diphosphate synthase of Rhodobacter sphaeroides for coenzyme Q10 production.

Applied microbiology and biotechnology 20061201

Farnesyl phosphates are endogenous ligands of lysophosphatidic acid receptors: inhibition of LPA GPCR and activation of PPARs.

Biochimica et biophysica acta 20061201

Direct observation of substrate-enzyme complexation by surface forces measurement.

Journal of the American Chemical Society 20061129

Characterization and tissue-specific expression of two lepidopteran farnesyl diphosphate synthase homologs: implications for the biosynthesis of ethyl-substituted juvenile hormones.

Proteins 20061115

Simvastatin inhibits the migration and adhesion of monocytic cells and disorganizes the cytoskeleton of activated endothelial cells.

European journal of pharmacology 20061024

The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding.

The Journal of biological chemistry 20060804

Geosmin biosynthesis in Streptomyces avermitilis. Molecular cloning, expression, and mechanistic study of the germacradienol/geosmin synthase.

The Journal of antibiotics 20060801

RhoA and p38 MAPK mediate apoptosis induced by cellular cholesterol depletion.

Apoptosis : an international journal on programmed cell death 20060701

Lovastatin-induced apoptosis in macrophages through the Rac1/Cdc42/JNK pathway.

Journal of immunology (Baltimore, Md. : 1950) 20060701

Geosmin biosynthesis. Streptomyces coelicolor germacradienol/germacrene D synthase converts farnesyl diphosphate to geosmin.

Journal of the American Chemical Society 20060628

Simvastatin decreases IL-6 and IL-8 production in epithelial cells.

Journal of dental research 20060601

Genome mining in Streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase.

Journal of the American Chemical Society 20060510

Theoretical studies on farnesyl cation cyclization: pathways to pentalenene.

Journal of the American Chemical Society 20060510

Cyclization mechanism of amorpha-4,11-diene synthase, a key enzyme in artemisinin biosynthesis.

Journal of natural products 20060501

Amorpha-4,11-diene synthase: mechanism and stereochemistry of the enzymatic cyclization of farnesyl diphosphate.

Archives of biochemistry and biophysics 20060415

How to evolve a silk purse from a sow's ear.

Nature chemical biology 20060401

Production of the artemisinin precursor amorpha-4,11-diene by engineered Saccharomyces cerevisiae.

Biotechnology letters 20060401

Convenient methods for the synthesis of P1-farnesyl-P2-indicator diphosphates.

Bioorganic & medicinal chemistry letters 20060315

Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids.

Journal of the American Chemical Society 20060308

A soluble form of phosphatase in Saccharomyces cerevisiae capable of converting farnesyl diphosphate into E,E-farnesol.

Applied biochemistry and biotechnology 20060201

Regulation of fatty acid synthesis by farnesyl pyrophosphate.

The Journal of biological chemistry 20051223

Interplay of isoprenoid and peptide substrate specificity in protein farnesyltransferase.

Biochemistry 20050823

Simvastatin inhibits NOR-1 expression induced by hyperlipemia by interfering with CREB activation.

Cardiovascular research 20050801

Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition: a role for RhoA in ABCA1-mediated cholesterol efflux.

The Journal of biological chemistry 20050610

Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis.

The Journal of biological chemistry 20050527

Directed library of anilinogeranyl analogues of farnesyl diphosphate via mixed solid- and solution-phase synthesis.

Organic letters 20050526

Cloning and expression of a farnesyl diphosphate synthase in Centella asiatica (L.) Urban.

Molecules and cells 20050430

Lovastatin-induced apoptosis in human melanoma cell lines.

Melanoma research 20050401

HMG-CoA reductase inhibition reduces monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated monocyte recruitment in vivo.

Circulation 20050322

Substrate and product specificities of cis-type undecaprenyl pyrophosphate synthase.

The Biochemical journal 20050215

Effect of pitavastatin on transactivation of human serum paraoxonase 1 gene.

Metabolism: clinical and experimental 20050201

Geranylgeranylated proteins are involved in the regulation of myeloma cell growth.

Clinical cancer research : an official journal of the American Association for Cancer Research 20050115

Simultaneous determination of farnesyl and geranylgeranyl pyrophosphate levels in cultured cells.

Analytical biochemistry 20050101

[Minodronic acid hydrate as a new therapeutic agent for osteoporosis].

Clinical calcium 20050101

Regulation of rubber biosynthetic rate and molecular weight in Hevea brasiliensis by metal cofactor.

Biomacromolecules 20050101

Computational and conformational evaluation of FTase alternative substrates: insight into a novel enzyme binding pocket.

Journal of chemical information and modeling 20050101

Tools to analyze protein farnesylation in cells.

Bioconjugate chemistry 20050101

A novel approach to prezizaane sesquiterpenes.

Chemistry & biodiversity 20041201

Synthesis and activity of fluorescent isoprenoid pyrophosphate analogues.

The Journal of organic chemistry 20041126

Statins inhibit in vitro calcification of human vascular smooth muscle cells induced by inflammatory mediators.

Journal of cellular biochemistry 20041115

Structure of 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase from Shewanella oneidensis at 1.6 A: identification of farnesyl pyrophosphate trapped in a hydrophobic cavity.

Acta crystallographica. Section D, Biological crystallography 20041101

Synthesis of acyloxymethyl ester prodrugs of the transferable protein farnesyl transferase substrate farnesyl methylenediphosphonate.

Bioorganic & medicinal chemistry letters 20041004

Dual role for phenylalanine 178 during catalysis by aristolochene synthase.

Chemical communications (Cambridge, England) 20040921

Glucose-potentiated chemotaxis in human vascular smooth muscle is dependent on cross-talk between the PI3K and MAPK signaling pathways.

Circulation research 20040820

Lysine beta311 of protein geranylgeranyltransferase type I partially replaces magnesium.

The Journal of biological chemistry 20040716

Differential effects of simvastatin on mesangial cells.

Kidney international 20040701

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (pravastatin) inhibits endothelial cell proliferation dependent on G1 cell cycle arrest.

Anti-cancer drugs 20040701

Simvastatin augments lipopolysaccharide-induced proinflammatory responses in macrophages by differential regulation of the c-Fos and c-Jun transcription factors.

Journal of immunology (Baltimore, Md. : 1950) 20040615

Atorvastatin completely inhibits VEGF-induced ACE upregulation in human endothelial cells.

American journal of physiology. Heart and circulatory physiology 20040601

Identification of a novel class of omega,E,E-farnesyl diphosphate synthase from Mycobacterium tuberculosis.

Journal of lipid research 20040601

Multisite inhibition by phenylacetate of PC-3 cell growth.

Anti-cancer drugs 20040601

Didehydrofarnesyl diphosphate: an intrinsically fluorescent inhibitor of protein farnesyltransferase.

Bioorganic & medicinal chemistry letters 20040503

HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis.

Journal of neurochemistry 20040401

Differential effects of prenyl pyrophosphates on the phosphatase activity of phosphotyrosyl protein phosphatase.

Journal of experimental zoology. Part A, Comparative experimental biology 20040401

Substrate binding mode and reaction mechanism of undecaprenyl pyrophosphate synthase deduced from crystallographic studies.

Protein science : a publication of the Protein Society 20040401

Isoprenoids: remarkable diversity of form and function.

Lipids 20040401

Statins inhibit osteoblast migration by inhibiting Rac-Akt signaling.

Biochemical and biophysical research communications 20040312

Mechanism and stereochemistry of the germacradienol/germacrene D synthase of Streptomyces coelicolor A3(2).

Journal of the American Chemical Society 20040310

Characterization of botryococcene synthase enzyme activity, a squalene synthase-like activity from the green microalga Botryococcus braunii, Race B.

Archives of biochemistry and biophysics 20040201

[The role of mevalonate pathway in osteogenic cells].

Nihon rinsho. Japanese journal of clinical medicine 20040201

Lovastatin and mevastatin reduce basal and cytokine-stimulated production of prostaglandins from rat microglial cells in vitro: evidence for a mechanism unrelated to the inhibition of hydroxy-methyl-glutaryl CoA reductase.

Neuroscience letters 20040109

Staphylococcus aureus mevalonate kinase: isolation and characterization of an enzyme of the isoprenoid biosynthetic pathway.

Journal of bacteriology 20040101

Cerivastatin-induced apoptosis of human aortic smooth muscle cells through partial inhibition of basal activation of extracellular signal-regulated kinases.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 20040101

Fluvastatin reduces renal fibroblast proliferation and production of type III collagen: therapeutic implications for tubulointerstitial fibrosis.

Nephron. Experimental nephrology 20040101

Mutagenesis studies of protein farnesyltransferase implicate aspartate beta 352 as a magnesium ligand.

The Journal of biological chemistry 20031219

Identification of the active conformation and the importance of length of the flexible loop 72-83 in regulating the conformational change of undecaprenyl pyrophosphate synthase.

Biochemistry 20031216

Statins induce suppressor of cytokine signaling-3 in macrophages.

FEBS letters 20031204

Synthesis of aniline-type analogues of farnesyl diphosphate and their biological assays for prenyl protein transferase inhibitory activity.

Farmaco (Societa chimica italiana : 1989) 20031201

Terpenoid metabolism in wild-type and transgenic Arabidopsis plants.

The Plant cell 20031201

Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho.

Science (New York, N.Y.) 20031114

Simvastatin modulates expression of the PON1 gene and increases serum paraoxonase: a role for sterol regulatory element-binding protein-2.

Arteriosclerosis, thrombosis, and vascular biology 20031101

Protein farnesyltransferase inhibitors interfere with farnesyl diphosphate binding by rubber transferase.

European journal of biochemistry 20031001

All hydrophobic HMG-CoA reductase inhibitors induce apoptotic death in rat pulmonary vein endothelial cells.

Atherosclerosis 20031001

Stabilisation of eudesmane cation by tryptophan 334 during aristolochene synthase catalysis.

Chemical communications (Cambridge, England) 20030907

Farnesyl pyrophosphate promotes and is essential for the binding of RACK1 with beta-tubulin.

Journal of experimental zoology. Part A, Comparative experimental biology 20030801

Effects of peroxisome proliferators gemfibrozil and clofibrate on syntheses of dolichol and cholesterol in rat liver.

Journal of biochemistry 20030801

A quantitative structure-activity relationship and pharmacophore modeling investigation of aryl-X and heterocyclic bisphosphonates as bone resorption agents.

Journal of medicinal chemistry 20030703

Evidence for differential folding of farnesyl pyrophosphate in the active site of aristolochene synthase: a single-point mutation converts aristolochene synthase into an (E)-beta-farnesene synthase.

Biochemistry 20030701

Detection of farnesyl diphosphate accumulation in yeast ERG9 mutants.

Analytical biochemistry 20030615

Biosynthesis of anthecotuloide, an irregular sesquiterpene lactone from Anthemis cotula L. (Asteraceae) via a non-farnesyl diphosphate route.

Organic & biomolecular chemistry 20030507

From pure FPP to mixed FPP and CAAX competitive inhibitors of farnesyl protein transferase.

Bioorganic & medicinal chemistry letters 20030417

Biochemical and structural studies with prenyl diphosphate analogues provide insights into isoprenoid recognition by protein farnesyl transferase.

Biochemistry 20030408

Synthesis and antimicrobial evaluation of farnesyl diphosphate mimetics.

Bioorganic chemistry 20030201

Effects of prenyl pyrophosphates on the binding of PKCgamma with RACK1.

Journal of experimental zoology. Part A, Comparative experimental biology 20030101

Cholesterol biosynthesis and regulation: role of peroxisomes.

Advances in experimental medicine and biology 20030101

Synthesis and application of a fluorescent substrate analogue to study ligand interactions for undecaprenyl pyrophosphate synthase.

Journal of the American Chemical Society 20021225

Feeding of [5,5-2H(2)]-1-desoxy-D-xylulose and [4,4,6,6,6-2H(5)]-mevalolactone to a geosmin-producing Streptomyces sp. and Fossombronia pusilla.

Phytochemistry 20021201

Cerivastatin, a HMG-CoA reductase inhibitor, reduces plasminogen activator inhibitor-1 (PAI-1) expression in endothelial cells by down-regulation of cellular signaling and the inhibition of PAI-1 promoter activity.

Japanese journal of pharmacology 20021201

Cerivastatin potentiates nitric oxide release and enos expression through inhibition of isoprenoids synthesis.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20021201

Isoprenoids influence expression of Ras and Ras-related proteins.

Biochemistry 20021119

Effects of prenyl pyrophosphates on the binding of S-Ras proteins with KSR.

The Journal of experimental zoology 20021101

Geranylgeranyl pyrophosphate counteracts the cataractogenic effect of lovastatin on cultured rat lenses.

Experimental eye research 20021101

Tyrosine 92 of aristolochene synthase directs cyclisation of farnesyl pyrophosphate.

Chemical communications (Cambridge, England) 20021021

Germacrene A is a product of the aristolochene synthase-mediated conversion of farnesylpyrophosphate to aristolochene.

Journal of the American Chemical Society 20021002

Synthesis of novel 4,1-benzoxazepine derivatives as squalene synthase inhibitors and their inhibition of cholesterol synthesis.

Journal of medicinal chemistry 20020926

Incadronate disodium inhibits advanced glycation end products-induced angiogenesis in vitro.

Biochemical and biophysical research communications 20020920

Synthesis of 7-substituted farnesyl diphosphate analogues.

Organic letters 20020905

Genetics of isoprenoid biosynthesis in Paracoccus zeaxanthinifaciens.

Gene 20020904

Central role of peroxisomes in isoprenoid biosynthesis.

Progress in lipid research 20020901

Inhibition of squalene synthase and squalene epoxidase in tobacco cells triggers an up-regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase.

Plant physiology 20020901

Alpha-phosphono lactone analogues of farnesyl pyrophosphate: an asymmetric synthesis via ring-closing metathesis.

The Journal of organic chemistry 20020809

[New therapeutic targets and strategies in lung cancer].

Archivos de bronconeumologia 20020801

Recombinant squalene synthase. Synthesis of non-head-to-tail isoprenoids in the absence of NADPH.

Journal of the American Chemical Society 20020731

Recombinant squalene synthase. A mechanism for the rearrangement of presqualene diphosphate to squalene.

Journal of the American Chemical Society 20020731

Photoaffinity analogues of farnesyl pyrophosphate transferable by protein farnesyl transferase.

Journal of the American Chemical Society 20020717

Alteration of product formation by directed mutagenesis and truncation of the multiple-product sesquiterpene synthases delta-selinene synthase and gamma-humulene synthase.

Archives of biochemistry and biophysics 20020601

Interaction of yeast Rab geranylgeranyl transferase with its protein and lipid substrates.

Biochemistry 20020528

Aromatic farnesyl diphosphate analogues: vinyl triflate-mediated synthesis and preliminary enzymatic evaluation.

Bioorganic & medicinal chemistry letters 20020520

Protein farnesyltransferase inhibitors.

Current medicinal chemistry 20020501

Cerivastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase, inhibits endothelial cell proliferation induced by angiogenic factors in vitro and angiogenesis in in vivo models.

Arteriosclerosis, thrombosis, and vascular biology 20020401

3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation.

Atherosclerosis 20020301

Insight into the activation mechanism of Escherichia coli octaprenyl pyrophosphate synthase derived from pre-steady-state kinetic analysis.

Biochimica et biophysica acta 20020131

Complex regulation of ABA biosynthesis in plants.

Trends in plant science 20020101

[Current state of carotenoid biosynthesis in chloroplasts of eucaryotes].

Zhurnal obshchei biologii 20020101

The in vivo synthesis of plant sesquiterpenes by Escherichia coli.

Biotechnology and bioengineering 20011205

GTPase stimulation in shrimp Ras(Q(61)K) with geranylgeranyl pyrophosphate but not mammalian GAP.

The Journal of experimental zoology 20011101

Protein farnesyltransferase isoprenoid substrate discrimination is dependent on isoprene double bonds and branched methyl groups.

Biochemistry 20011016

Synthesis of (S)-isoprenoid thiodiphosphates as substrates and inhibitors.

The Journal of organic chemistry 20011005

Functional properties of diapophytoene and related desaturases of C(30) and C(40) carotenoid biosynthetic pathways.

Biochimica et biophysica acta 20010928

Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase.

The Journal of biological chemistry 20010907

Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells.

Leukemia 20010901

Lipophilic statins can be osteogenic by promoting osteoblastic calcification in a Cbfa1- and BMP-2-independent manner.

Methods and findings in experimental and clinical pharmacology 20010901

Rho-dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins).

British journal of pharmacology 20010801

Characterization of phosphoantigens by high-performance anion-exchange chromatography-electrospray ionization ion trap mass spectrometry and nanoelectrospray ionization ion trap mass spectrometry.

Analytical chemistry 20010801

Partial characterization of farnesyl and geranylgeranyl diphosphatases induced in rice seedlings by UV-C irradiation.

Plant & cell physiology 20010801

Dominant negative farnesyltransferase alpha-subunit inhibits insulin mitogenic effects.

Biochemical and biophysical research communications 20010713

Structural features of nonpeptide prenyl pyrophosphates that determine their antigenicity for human gamma delta T cells.

Journal of immunology (Baltimore, Md. : 1950) 20010701

Statins suppress THP-1 cell migration and secretion of matrix metalloproteinase 9 by inhibiting geranylgeranylation.

Journal of leukocyte biology 20010601

Synthesis of farnesyl diphosphate analogues containing ether-linked photoactive benzophenones and their application in studies of protein prenyltransferases.

The Journal of organic chemistry 20010518

Labeling patterns of chloroplastidic isoprenoids in cultured cells of liverwort Ptychanthus striatus.

Bioscience, biotechnology, and biochemistry 20010501

Inhibition of endothelial cell migration by cerivastatin, an HMG-CoA reductase inhibitor: contribution to its anti-angiogenic effect.

FEBS letters 20010427

The cyclization of farnesyl diphosphate and nerolidyl diphosphate by a purified recombinant delta-cadinene synthase.

Plant physiology 20010401

Partial purification and characterization of the short-chain prenyltransferases, gernayl diphospate synthase and farnesyl diphosphate synthase, from Abies grandis (grand fir).

Archives of biochemistry and biophysics 20010215

Study on the biosynthesis of dolichol in yeast: recognition of the prenyl chain length in polyprenol reduction.

Journal of biochemistry 20010201

Lovastatin induces apoptosis of spontaneously immortalized rat brain neuroblasts: involvement of nonsterol isoprenoid biosynthesis inhibition.

Molecular and cellular neurosciences 20010201

Cracking down on caveolin: role of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in modulating edothelial cell nitric oxide production.

Circulation 20010102

Arglabin-DMA, a plant derived sesquiterpene, inhibits farnesyltransferase.

Oncology reports 20010101

Involvement of Rho GTPases in the transcriptional inhibition of preproendothelin-1 gene expression by simvastatin in vascular endothelial cells.

Circulation research 20000929

Simvastatin modulates cytokine-mediated endothelial cell adhesion molecule induction: involvement of an inhibitory G protein.

Journal of immunology (Baltimore, Md. : 1950) 20000901

The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures.

Structure (London, England : 1993) 20000215

Farnesol is utilized for isoprenoid biosynthesis in plant cells via farnesyl pyrophosphate formed by successive monophosphorylation reactions.

Proceedings of the National Academy of Sciences of the United States of America 19991109

Cloning, expression, and characterization of epi-cedrol synthase, a sesquiterpene cyclase from Artemisia annua L.

Archives of biochemistry and biophysics 19990915

Spider mite-induced (3S)-(E)-nerolidol synthase activity in cucumber and lima bean. The first dedicated step in acyclic C11-homoterpene biosynthesis.

Plant physiology 19990901

Lovastatin augments apoptosis induced by chemotherapeutic agents in colon cancer cells.

Clinical cancer research : an official journal of the American Association for Cancer Research 19990801

Isolation, characterization, and mechanistic studies of (-)-alpha-gurjunene synthase from Solidago canadensis.

Archives of biochemistry and biophysics 19990415

Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue.

Biochemistry 19981124

Truncation of human squalene synthase yields active, crystallizable protein.

Archives of biochemistry and biophysics 19980215

Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways.

Journal of lipid research 19971101

Identification of catalytic residues in human mevalonate kinase.

The Journal of biological chemistry 19971010

Structural basis for cyclic terpene biosynthesis by tobacco 5-epi-aristolochene synthase.

Science (New York, N.Y.) 19970919

Natural and synthetic non-peptide antigens recognized by human gamma delta T cells.

Nature 19950511

Expression, purification, and characterization of the human squalene synthase: use of yeast and baculoviral systems.

Archives of biochemistry and biophysics 19950201

Solubilization, purification, and characterization of a truncated form of rat hepatic squalene synthetase.

The Journal of biological chemistry 19920425

Purification and regulation of mevalonate kinase from rat liver.

The Journal of biological chemistry 19900205

The biosynthesis of dehydrodolichyl phosphates by rat liver microsomes.

Biochimica et biophysica acta 19890403

Squalene synthetase.

Methods in enzymology 19850101

13058-04-3 | Diphosphoric acid, P-(3,7,11-trimethyl-2,6,10-dodecatrien-1-yl) ester

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