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130465-45-1 | 1H-2-Benzopyran-5,6-diol, 1-(aminomethyl)-3,4-dihydro-3-phenyl-, (1R,3S)-
CAS No: 130465-45-1 Catalog No: AG000UG9 MDL No:
Product Description
Catalog Number:
AG000UG9
Chemical Name:
1H-2-Benzopyran-5,6-diol, 1-(aminomethyl)-3,4-dihydro-3-phenyl-, (1R,3S)-
CAS Number:
130465-45-1
Molecular Formula:
C16H17NO3
Molecular Weight:
271.3111
IUPAC Name:
(1R,3S)-1-(aminomethyl)-3-phenyl-3,4-dihydro-1H-isochromene-5,6-diol
InChI:
InChI=1S/C16H17NO3/c17-9-15-11-6-7-13(18)16(19)12(11)8-14(20-15)10-4-2-1-3-5-10/h1-7,14-15,18-19H,8-9,17H2/t14-,15-/m0/s1
InChI Key:
SUHGRZPINGKYNV-GJZGRUSLSA-N
SMILES:
NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1
UNII:
B4NI77O5D4
Properties
Complexity:
319
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
2
Defined Bond Stereocenter Count:
0
Exact Mass:
271.121g/mol
Formal Charge:
0
Heavy Atom Count:
20
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
271.316g/mol
Monoisotopic Mass:
271.121g/mol
Rotatable Bond Count:
2
Topological Polar Surface Area:
75.7A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.5
Literature
| Title | Journal |
|---|---|
| Increase of ryanodine receptors by dopamine D1 receptors is negatively regulated by γ-aminobutyric acid type B receptors in primary cultures of mouse cerebral cortical neurons. | Journal of neuroscience research 20120801 |
| Neuroprotective and anti-stress effect of A68930 in acute and chronic unpredictable stress model in rats. | Neuroscience letters 20111024 |
| Therapeutic effect of D1-like dopamine receptor antagonist on collagen-induced arthritis of mice. | Modern rheumatology 20110601 |
| Behavioural and pharmacological examinations in a transgenic mouse model of early-onset torsion dystonia. | Pharmacology, biochemistry, and behavior 20110201 |
| Differential response of A 68930 and sulpiride in stress-induced gastric ulcers in rats. | European journal of pharmacology 20100915 |
| D1 receptor antagonist-induced long-term depression in the medial prefrontal cortex of rat, in vivo: an animal model of psychiatric hypofrontality. | Journal of psychopharmacology (Oxford, England) 20090801 |
| [Effects of A68930 on rhythmical respiratory discharge in isolated neonatal rat brainstem slice]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20090101 |
| Stereotypic circling behavior in mice with vestibular dysfunction: asymmetrical effects of intrastriatal microinjection of a dopamine agonist. | The International journal of neuroscience 20070701 |
| Dopamine D1 receptors co-distribute with N-methyl-D-aspartic acid type-1 subunits and modulate synaptically-evoked N-methyl-D-aspartic acid currents in rat basolateral amygdala. | Neuroscience 20061027 |
| Disruption of orofacial movement topographies in congenic mutants with dopamine D5 but not D4 receptor or DARPP-32 transduction 'knockout'. | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20060801 |
| Differences between A 68930 and SKF 82958 could suggest synergistic roles of D1 and D5 receptors. | Pharmacology, biochemistry, and behavior 20051101 |
| Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists. | Molecular pharmacology 20051001 |
| Peripheral relaxant activity of apomorphine and of a D1 selective receptor agonist on human corpus cavernosum strips. | International journal of impotence research 20050101 |
| Impaired SynGAP expression and long-term spatial learning and memory in hippocampal CA1 area from rats previously exposed to perinatal hypoxia-induced insults: beneficial effects of A68930. | Neuroscience letters 20041116 |
| A 68930 and dihydrexidine inhibit locomotor activity and d-amphetamine-induced hyperactivity in rats: a role of inhibitory dopamine D(1/5) receptors in the prefrontal cortex? | Neuroscience 20040101 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| Comparative, topographically-based evaluation of behavioural phenotype and specification of D(1)-like:D(2) interactions in a line of incipient congenic mice with D(2) dopamine receptor 'knockout'. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20011001 |
| Topographical assessment and pharmacological characterization of orofacial movements in mice: dopamine D(1)-like vs. D(2)-like receptor regulation. | European journal of pharmacology 20010420 |
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