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Home > Indoles and Oxindole > 130308-48-4
130308-48-4 | L-Arginine, D-arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-(3R)-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-(2S,3aS,7aS)-octahydro-1H-indole-2-carbonyl-
CAS No: 130308-48-4 Catalog No: AG000U9B MDL No:MFCD00213940
Product Description
Catalog Number:
AG000U9B
Chemical Name:
L-Arginine, D-arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-(3R)-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-(2S,3aS,7aS)-octahydro-1H-indole-2-carbonyl-
CAS Number:
130308-48-4
Molecular Formula:
C59H89N19O13S
Molecular Weight:
1304.5225
MDL Number:
MFCD00213940
IUPAC Name:
(2S)-2-[[(2S,3aS,7aS)-1-[(3R)-2-[(2S)-2-[[(2S)-2-[[2-[[(2S,4R)-1-[(2S)-1-[(2S)-2-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]-4-hydroxypyrrolidine-2-carbonyl]amino]acetyl]amino]-3-thiophen-2-ylpropanoyl]amino]-3-hydroxypropanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid
InChI:
InChI=1S/C59H89N19O13S/c60-37(14-5-19-67-57(61)62)48(82)72-38(15-6-20-68-58(63)64)52(86)75-22-8-18-43(75)54(88)77-30-35(80)26-44(77)50(84)70-28-47(81)71-40(27-36-13-9-23-92-36)49(83)74-41(31-79)53(87)76-29-34-12-2-1-10-32(34)24-46(76)55(89)78-42-17-4-3-11-33(42)25-45(78)51(85)73-39(56(90)91)16-7-21-69-59(65)66/h1-2,9-10,12-13,23,33,35,37-46,79-80H,3-8,11,14-22,24-31,60H2,(H,70,84)(H,71,81)(H,72,82)(H,73,85)(H,74,83)(H,90,91)(H4,61,62,67)(H4,63,64,68)(H4,65,66,69)/t33-,35+,37+,38-,39-,40-,41-,42-,43-,44-,45-,46+/m0/s1
InChI Key:
QURWXBZNHXJZBE-SKXRKSCCSA-N
SMILES:
OC[C@@H](C(=O)NC(=N)NCCC[C@H](N(C(=O)[C@@H]1NCc2c(C1)cccc2)C(=O)C1N[C@@H]2[C@H](C1)CCCC2)C(=O)O)NC(=O)[C@H](Cc1cccs1)NC(=O)CNC(=O)[C@@H]1C[C@H](CN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](CCCNC(=N)N)N)CCCNC(=N)N)O
UNII:
7PG89G35Q7
Properties
Complexity:
2720
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
12
Defined Bond Stereocenter Count:
0
Exact Mass:
1303.661g/mol
Formal Charge:
0
Heavy Atom Count:
92
Hydrogen Bond Acceptor Count:
18
Hydrogen Bond Donor Count:
15
Isotope Atom Count:
0
Molecular Weight:
1304.541g/mol
Monoisotopic Mass:
1303.661g/mol
Rotatable Bond Count:
30
Topological Polar Surface Area:
552A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-6.4
Literature
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| Synergistic actions of enalapril and tempol during chronic angiotensin II-induced hypertension. | Vascular pharmacology 20070201 |
| Characterization of kinin receptors in human cultured detrusor smooth muscle cells. | British journal of pharmacology 20070101 |
| Bradykinin is a mediator, but unlikely a trigger, of antiarrhythmic effects of ischemic preconditioning. | Journal of cardiovascular electrophysiology 20070101 |
| The bradykinin B2 receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B1 and angiotensin receptors. | European journal of pharmacology 20061203 |
| Roles of leukocytosis and cysteinyl leukotriene in polymorphonuclear leukocyte-dependent plasma extravasation. | Journal of leukocyte biology 20061201 |
| Novel pharmacotherapy of acute hereditary angioedema with bradykinin B2-receptor antagonist icatibant. | Allergy 20061201 |
| Renal cortical regulation of COX-1 and functionally related products in early renovascular hypertension (rat). | American journal of physiology. Renal physiology 20061101 |
| Angiotensin II type 2 receptor expression after vascular injury: differing effects of angiotensin-converting enzyme inhibition and angiotensin receptor blockade. | Hypertension (Dallas, Tex. : 1979) 20061101 |
| Angiotensin-(1-7) potentiates responses to bradykinin but does not change responses to angiotensin I. | Canadian journal of physiology and pharmacology 20061101 |
| Tissue kallikrein stimulates Ca(2+) reabsorption via PKC-dependent plasma membrane accumulation of TRPV5. | The EMBO journal 20061018 |
| Kinin modulation of conventional outflow facility in the bovine eye. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20061001 |
| AT1 receptor blockade prevents microvascular dysfunction induced by ischemia/reperfusion injury. | Journal of atherosclerosis and thrombosis 20061001 |
| Kinins and neuroinflammation: dual effect on prostaglandin synthesis. | European journal of pharmacology 20060928 |
| Angiotensin-converting enzyme inhibitor-related angioedema: how to deal with it. | Expert opinion on drug safety 20060901 |
| Inhibition of angiotensin-converting enzyme reduces rat liver reperfusion injury via bradykinin-2-receptor. | The Journal of surgical research 20060801 |
| Bradykinin B2 receptor knockout mice are protected from thrombosis by increased nitric oxide and prostacyclin. | Blood 20060701 |
| Ramipril treatment protects against nitrate-induced oxidative stress in eNOS-/- mice: An implication of the NADPH oxidase pathway. | Journal of cardiovascular pharmacology 20060701 |
| Role of bradykinin B2 receptors in the modulation of the peristaltic reflex of the guinea pig isolated ileum. | European journal of pharmacology 20060606 |
| Prostaglandin involvement in lung C-fiber activation by substance P in guinea pigs. | Journal of applied physiology (Bethesda, Md. : 1985) 20060601 |
| Substance P release evoked by capsaicin or potassium from rat cultured dorsal root ganglion neurons is conversely modulated with bradykinin. | Journal of neurochemistry 20060601 |
| Bradykinin mediates phosphorylation of eNOS in odontoblasts. | Journal of dental research 20060601 |
| Experimental therapy with tissue kallikrein against cerebral ischemia. | Frontiers in bioscience : a journal and virtual library 20060501 |
| Bradykinin antagonists modified with dipeptide mimetic beta-turn inducers. | Bioorganic & medicinal chemistry letters 20060501 |
| Peptide and non-peptide bradykinin receptor antagonists: role in allergic airway disease. | European journal of pharmacology 20060308 |
| Kallikrein/kinin protects against gentamicin-induced nephrotoxicity by inhibition of inflammation and apoptosis. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060301 |
| Potentiation of nicotinic currents by bradykinin in the paratracheal ganglia neurons of rats. | European journal of pharmacology 20060215 |
| B(2)-receptor modulation of the reactivity to phenylephrine and angiotensin II in the carotid artery of normotensive rats after trandolapril treatment. | Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20060201 |
| Angiotensin II type 1 receptor antagonism improves endothelial vasodilator function in L-NAME-induced hypertensive rats by a kinin-dependent mechanism. | Journal of hypertension 20060101 |
| Modulation of renal kallikrein by a high potassium diet in rats with intense proteinuria. | Kidney international 20060101 |
| Mechanism of non-capacitative Ca2+ influx in response to bradykinin in vascular endothelial cells. | Journal of vascular research 20060101 |
| Pharmacological enhancement of the kallikrein-kinin system promotes anti-fibrotic responses in human mesangial cells. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20060101 |
| MEN16132, a novel potent and selective nonpeptide antagonist for the human bradykinin B2 receptor. In vitro pharmacology and molecular characterization. | European journal of pharmacology 20051228 |
| [Mechanism of cardioprotection against ischemia/reperfusion injury by valsartan: an experiment with isolated rat hearts]. | Zhonghua yi xue za zhi 20051214 |
| Activation of splanchnic and pelvic colonic afferents by bradykinin in mice. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20051201 |
| Bradykinin B2 receptor antagonism attenuates inflammation, mast cell infiltration and fibrosis in remote myocardium after infarction in rats. | Clinical and experimental pharmacology & physiology 20051201 |
| Optical biosensor provides insights for bradykinin B(2) receptor signaling in A431 cells. | FEBS letters 20051121 |
| Does insulin release kinins in rats? | European journal of pharmacology 20051121 |
| MEN16132, a novel potent and selective nonpeptide kinin B2 receptor antagonist: in vivo activity on bradykinin-induced bronchoconstriction and nasal mucosa microvascular leakage in anesthetized guinea pigs. | The Journal of pharmacology and experimental therapeutics 20051101 |
| A pilot study indicating that bradykinin B2 receptor antagonism attenuates protamine-related hypotension after cardiopulmonary bypass. | Clinical pharmacology and therapeutics 20051101 |
| Antagonistic effects of novel non-peptide chlorobenzhydryl piperazine compounds on contractile response to bradykinin in the guinea-pig ileum. | European journal of pharmacology 20051031 |
| Mechanisms involved in the nociception produced by peripheral protein kinase c activation in mice. | Pain 20050901 |
| The kallikrein-kinin system: current and future pharmacological targets. | Journal of pharmacological sciences 20050901 |
| Kinin and opioid receptors in the paratrigeminal nucleus modulate the somatosensory reflex to rat sciatic nerve stimulation. | Peptides 20050801 |
| Bradykinin B2 type receptor activation regulates fluid and electrolyte transport in the rabbit kidney. | Peptides 20050801 |
| Role of transient receptor potential vanilloid 1 receptors in adjuvant-induced chronic arthritis: in vivo study using gene-deficient mice. | The Journal of pharmacology and experimental therapeutics 20050701 |
| A possible alternative mechanism of kinin generation in vivo by cathepsin L. | Biological chemistry 20050701 |
| Angiotensin-converting enzyme inhibition and angiotensin AT1-receptor antagonism equally improve endothelial vasodilator function in L-NAME-induced hypertensive rats. | European journal of pharmacology 20050615 |
| Neuronal differentiation of P19 embryonal carcinoma cells modulates kinin B2 receptor gene expression and function. | The Journal of biological chemistry 20050520 |
| Bradykinin potentiates 5-HT3 receptor-mediated current in rat trigeminal ganglion neurons. | Acta pharmacologica Sinica 20050401 |
| Bradykinin upregulates IL-8 production in human gingival fibroblasts stimulated by interleukin-1beta and tumor necrosis factor alpha. | Regulatory peptides 20050330 |
| Kallikrein/kinin protects against myocardial apoptosis after ischemia/reperfusion via Akt-glycogen synthase kinase-3 and Akt-Bad.14-3-3 signaling pathways. | The Journal of biological chemistry 20050304 |
| Fate of bradykinin on the rat liver when administered by the venous or arterial route. | Journal of gastroenterology and hepatology 20050301 |
| CB(1) cannabinoid receptor stimulation modulates transient receptor potential vanilloid receptor 1 activities in calcium influx and substance P Release in cultured rat dorsal root ganglion cells. | Journal of pharmacological sciences 20050301 |
| Hit to Lead Success Stories--IBC Conference: Effective chemistry strategies for reducing attrition rates and speeding lead compounds into the pipeline. 31 January-1 February 2005, San Diego, CA, USA. | IDrugs : the investigational drugs journal 20050301 |
| Expression and function of bradykinin B1 and B2 receptors in normal and inflamed rat urinary bladder urothelium. | The Journal of physiology 20050201 |
| Altered renal response to acute volume expansion in transgenic rats harboring the human tissue kallikrein gene. | Regulatory peptides 20050115 |
| Icatibant: HOE 140, JE 049, JE049. | Drugs in R&D 20050101 |
| ACE inhibition lowers angiotensin-II-induced monocyte adhesion to HUVEC by reduction of p65 translocation and AT 1 expression. | Journal of vascular research 20050101 |
| Effects of bradykinin on cardiovascular remodeling in renovascular hypertensive rats. | Hypertension research : official journal of the Japanese Society of Hypertension 20041101 |
| Intracellular signalings underlying bradykinin-induced matrix metalloproteinase-9 expression in rat brain astrocyte-1. | Cellular signalling 20041001 |
| Bradykinin antagonists have no analgesic effect on incisional pain. | Anesthesia and analgesia 20041001 |
| Up-regulated neuronal nitric oxide synthase compensates coronary flow response to bradykinin in endothelial nitric oxide synthase-deficient mice. | Journal of cardiovascular pharmacology 20041001 |
| Nephroprotection in Zucker diabetic fatty rats by vasopeptidase inhibition is partly bradykinin B2 receptor dependent. | British journal of pharmacology 20040901 |
| Mechanism of the endothelium-dependent vasodilation and the antihypertensive effect of Brazilian red wine. | Journal of cardiovascular pharmacology 20040901 |
| Pharmacological and histopathological characterization of Bothrops lanceolatus (Fer de lance) venom-induced edema. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20040701 |
| Flow-dependent dilation mediated by endogenous kinins requires angiotensin AT2 receptors. | Circulation research 20040625 |
| Stimulation of cyclic GMP production via AT2 and B2 receptors in the pressure-overloaded aorta after banding. | Hypertension (Dallas, Tex. : 1979) 20040601 |
| Hoe 140 abolishes the blood pressure lowering effect of taurine in high fructose-fed rats. | Amino acids 20040601 |
| The N-terminal of icatibant and bradykinin interact with the same Asp residues in the human B2 receptor. | European journal of pharmacology 20040503 |
| Correlation between brain bradykinin receptor binding sites and cardiovascular function in young and adult spontaneously hypertensive rats. | British journal of pharmacology 20040501 |
| Prevention of cardiac fibrosis and left ventricular dysfunction in diabetic cardiomyopathy in rats by transgenic expression of the human tissue kallikrein gene. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040501 |
| Pharmacological characterization of canine bradykinin receptors in prostatic culture and in isolated prostate. | British journal of pharmacology 20040501 |
| BK2 but not BK1 receptors mediating contractile response in human umbilical arteries: role of thromboxane A2. | Methods and findings in experimental and clinical pharmacology 20040501 |
| Angiotensin-(1-7) inhibits the angiotensin II-enhanced norepinephrine release in coarcted hypertensive rats. | Regulatory peptides 20040415 |
| Action of bradykinin in the submucosal plexus of guinea pig small intestine. | The Journal of pharmacology and experimental therapeutics 20040401 |
| Involvement of bradykinin, cytokines, sympathetic amines and prostaglandins in formalin-induced orofacial nociception in rats. | British journal of pharmacology 20040401 |
| Differential regulation of collecting duct Na+, K+-ATPase and K+ excretion by furosemide and piretanide: role of bradykinin. | Journal of the American Society of Nephrology : JASN 20040401 |
| The role of bradykinin in the antifibrotic actions of perindoprilat on human mesangial cells. | Kidney international 20040401 |
| Cell survival signalling in heart derived myofibroblasts induced by preconditioning and bradykinin: the role of p38 MAP kinase. | Molecular and cellular biochemistry 20040401 |
| Bradykinin and matrix metalloproteinases are involved the structural alterations of rat small resistance arteries with inhibition of ACE and NEP. | Journal of hypertension 20040401 |
| A new series of highly potent non-peptide bradykinin B2 receptor antagonists incorporating the 4-heteroarylquinoline framework. Improvement of aqueous solubility and new insights into species difference. | Journal of medicinal chemistry 20040325 |
| Role of bradykinin B2 and B1 receptors in the local, remote, and systemic inflammatory responses that follow intestinal ischemia and reperfusion injury. | Journal of immunology (Baltimore, Md. : 1950) 20040215 |
| Kinin B2 receptor is not involved in enalapril-induced apoptosis and regression of hypertrophy in spontaneously hypertensive rat aorta: possible role of B1 receptor. | British journal of pharmacology 20040201 |
| Modulation of allergic and immune complex-induced lung inflammation by bradykinin receptor antagonists. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20040201 |
| Involvement of nitric oxide and prostaglandin pathways in the cardioprotective actions of bradykinin in rats with experimental myocardial infarction. | Pharmacological research 20040101 |
| Changes in vascular distensibility during angiotensin-converting enzyme inhibition involve bradykinin type 2 receptors. | Journal of vascular research 20040101 |
| Potential role of kinins in the effects of taurine in high-fructose-fed rats. | Canadian journal of physiology and pharmacology 20040101 |
| Icatibant: HOE 140, JE 049, JE049. | Drugs in R&D 20040101 |
| Infarct size limiting effect of apstatin alone and in combination with enalapril, lisinopril and ramipril in rats with experimental myocardial infarction. | Pharmacological research 20031201 |
| Converting enzyme inhibitor temocaprilat prevents high glucose-mediated suppression of human aortic endothelial cell proliferation. | Journal of cardiovascular pharmacology 20031201 |
| Protective effect of bradykinin antagonist Hoe-140 during in vivo myocardial ischemic-reperfusion injury in the cat. | Regulatory peptides 20031015 |
| Autoradiographic localization of [125I-Tyr0]bradykinin binding sites in brains of Wistar-Kyoto and spontaneously hypertensive rats. | Cellular and molecular neurobiology 20031001 |
| Amlodipine activates the endothelial nitric oxide synthase by altering phosphorylation on Ser1177 and Thr495. | Cardiovascular research 20031001 |
| Secretory dysfunction of vascular endothelium limits the effect of angiotensin converting enzyme inhibitor quinapril on aggregation of erythrocytes in experimental hypertension. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20030901 |
| Kinins are involved in the development of allergic nasal hyperresponsiveness in guinea pigs. | European journal of pharmacology 20030829 |
| Bradykinin B2 receptors mediate contraction in the normal and inflamed human gallbladder in vitro. | Gastroenterology 20030701 |
| Changes in amino-terminal portion of human B2 receptor selectively increase efficacy of synthetic ligand HOE 140 but not of cognate ligand bradykinin. | American journal of physiology. Heart and circulatory physiology 20030601 |
| Metalloendopeptidases EC 3.4.24.15/16 regulate bradykinin activity in the cerebral microvasculature. | American journal of physiology. Heart and circulatory physiology 20030601 |
| Kininase I-type carboxypeptidases enhance nitric oxide production in endothelial cells by generating bradykinin B1 receptor agonists. | American journal of physiology. Heart and circulatory physiology 20030601 |
| AT1-receptor antagonism improves endothelial function in coronary artery disease by a bradykinin/B2-receptor-dependent mechanism. | Hypertension (Dallas, Tex. : 1979) 20030501 |
| Transactivation of KDR/Flk-1 by the B2 receptor induces tube formation in human coronary endothelial cells. | Hypertension (Dallas, Tex. : 1979) 20030501 |
| Enalaprilat, losartan and LU 135252 in coronary blood flow regulation. | European journal of clinical investigation 20030501 |
| Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: pharmacological mediation and molecular determinants. | Toxicon : official journal of the International Society on Toxinology 20030501 |
| Role of the bradykinin B2 receptor for the local and systemic inflammatory response that follows severe reperfusion injury. | British journal of pharmacology 20030501 |
| Effect of a kinin B2 receptor antagonist on LPS- and cytokine-induced neutrophil migration in rats. | British journal of pharmacology 20030501 |
| Mechanism of kinin release during experimental acute pancreatitis in rats: evidence for pro- as well as anti-inflammatory roles of oedema formation. | British journal of pharmacology 20030501 |
| Vasopeptidase inhibitor omapatrilat induces profound insulin sensitization and increases myocardial glucose uptake in Zucker fatty rats: Studies comparing a vasopeptidase inhibitor, angiotensin-converting enzyme inhibitor, and angiotensin II type I receptor blocker. | Circulation 20030415 |
| Modulation of cutaneous inflammation by angiotensin-converting enzyme. | Journal of immunology (Baltimore, Md. : 1950) 20030401 |
| Amelioration of hyperalgesia by kinin receptor antagonists or kininogen deficiency in chronic constriction nerve injury in rats. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20030401 |
| Kinins are involved in the antiproteinuric effect of angiotensin-converting enzyme inhibition in experimental diabetic nephropathy. | International immunopharmacology 20030301 |
| Combined action of vasoactive amines and bradykinin mediates allergen-evoked thermal hyperalgesia in rats. | European journal of pharmacology 20030221 |
| Angiotensin-converting enzyme inhibition increases human vascular tissue-type plasminogen activator release through endogenous bradykinin. | Circulation 20030204 |
| Angiotensin II and renal medullary blood flow in Lyon rats. | American journal of physiology. Renal physiology 20030201 |
| B2 bradykinin receptor mediates the stimulatory effect of bradykinin on rat germ cell proliferation in vitro. | Andrologia 20030201 |
| Differential modulation of murine lung inflammation by bradykinin B1 and B2 selective receptor antagonists. | European journal of pharmacology 20030126 |
| Characterisation of bradykinin B1 and B2 receptors using rat isolated vas deferens. | European journal of pharmacology 20030105 |
| Bradykinin B1 and B2 receptors differentially regulate cardiac Na+-H+ exchanger, Na+-Ca2+ exchanger and Na+-HCO3- symporter. | European journal of pharmacology 20030101 |
| Study of the mechanisms involved in the bradykinin-induced contraction of the pig iris sphincter muscle in vitro. | European journal of pharmacology 20030101 |
| Renoprotective effects of omapatrilat are mediated partially by bradykinin. | American journal of nephrology 20030101 |
| Effect of neutral endopeptidase inhibition on vascular response induced by exogenous angiotensin I in the isolated rat lung. | Polish journal of pharmacology 20030101 |
| Intrathecal bradykinin administration: opposite effects on nociceptive transmission. | Pharmacology 20021001 |
| Diuretic response to acute hypertension is blunted during angiotensin II clamp. | American journal of physiology. Regulatory, integrative and comparative physiology 20021001 |
| Bradykinin does not mediate cutaneous active vasodilation during heat stress in humans. | Journal of applied physiology (Bethesda, Md. : 1985) 20021001 |
| Remote preconditioning protects the heart by activating myocardial PKCepsilon-isoform. | Cardiovascular research 20020815 |
| In vivo bradykinin B2 receptor activation reduces renal fibrosis. | The Journal of clinical investigation 20020801 |
| Inhibition of angiotesin-converting enzyme by quercetin alters the vascular response to brandykinin and angiotensin I. | Pharmacology 20020801 |
| Interaction of linear and cyclic peptide antagonists at the human B(2) kinin receptor. | Peptides 20020801 |
| Bradykinin-induced neuropeptide Y release by human pheochromocytoma tissue. | Neuropeptides 20020801 |
| Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers synergistically increase coronary blood flow in canine ischemic myocardium: role of bradykinin. | Journal of the American College of Cardiology 20020703 |
| Biocompatibility of thermosensitive chitosan-based hydrogels: an in vivo experimental approach to injectable biomaterials. | Biomaterials 20020701 |
| Bradykinin is involved in hyperalgesia induced by Bothrops jararaca venom. | Toxicon : official journal of the International Society on Toxinology 20020701 |
| Icatibant blocks but does not reverse ACE inhibitor renal effect in Goldblatt rabbit. | Clinical and experimental hypertension (New York, N.Y. : 1993) 20020701 |
| Activity and functional significance of the renal kallikrein-kinin-system in polycystic kidney disease of the rat. | Kidney international 20020601 |
| B1 and B2 antagonists and bradykinin-induced blood flow in rat skin inflammation. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20020601 |
| Angiotensin II type 2 receptor gene transfer downregulates angiotensin II type 1a receptor in vascular smooth muscle cells. | Hypertension (Dallas, Tex. : 1979) 20020501 |
| Myocardial blood flow after chronic cardiac decentralization in anesthetized dogs: effects of ACE-inhibition. | Autonomic neuroscience : basic & clinical 20020418 |
| Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor. | The Journal of clinical investigation 20020415 |
| Synthesis and analysis of potent, more lipophilic derivatives of the bradykinin B2 receptor antagonist peptide Hoe 140. | The journal of peptide research : official journal of the American Peptide Society 20020401 |
| Cardiovascular effects of peptide kinin B2 receptor antagonists in rats. | Canadian journal of physiology and pharmacology 20020401 |
| Identification of bradykinin receptors in clinical cancer specimens and murine tumor tissues. | International journal of cancer 20020301 |
| Induction of functional bradykinin b(1)-receptors in normotensive rats and mice under chronic Angiotensin-converting enzyme inhibitor treatment. | Circulation 20020205 |
| Role of kallikrein-kininogen system in insulin-stimulated glucose transport after muscle contractions. | Journal of applied physiology (Bethesda, Md. : 1985) 20020201 |
| Role of bradykinin in acid-induced mesenteric hyperemia and duodenal villous damage. | Life sciences 20020104 |
| Blockade of bradykinin B(2) receptor suppresses acute pancreatitis induced by obstruction of the pancreaticobiliary duct in rats. | British journal of pharmacology 20020101 |
| Pharmacological and functional characterization of the guinea-pig B2 bradykinin receptor stably expressed in CHO-K1 cell line. | British journal of pharmacology 20020101 |
| [Bradykinin antagonist: current status and perspective]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20020101 |
| Neutral endopeptidase knockout induces hyperalgesia in a model of visceral pain, an effect related to bradykinin and nitric oxide. | Journal of molecular neuroscience : MN 20020101 |
| Palmitoylation of the human bradykinin B2 receptor influences ligand efficacy. | Biochemistry 20011225 |
| Interactive contribution of NK(1) and kinin receptors to the acute inflammatory oedema observed in response to noxious heat stimulation: studies in NK(1) receptor knockout mice. | British journal of pharmacology 20011201 |
| A potential role of bradykinin in angiogenesis and growth of S-180 mouse tumors. | Japanese journal of pharmacology 20011201 |
| Involvement of vanilloid receptor VR1 and prostanoids in the acid-induced writhing responses of mice. | Life sciences 20011102 |
| Human airway smooth muscle cells secrete vascular endothelial growth factor: up-regulation by bradykinin via a protein kinase C and prostanoid-dependent mechanism. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20011101 |
| Changes in blood glucose and plasma insulin levels induced by bradykinin in anaesthetized rats. | British journal of pharmacology 20011101 |
| Analysis of the mechanisms involved in the inflammatory response induced by des-Arg9-bradykinin in the rat pleural cavity. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20011101 |
| Bradykinin contributes to the vasodilator effects of chronic angiotensin-converting enzyme inhibition in patients with heart failure. | Circulation 20011030 |
| Metalloendopeptidases EC 3.4.24.15 and EC 3.4.24.16 and bradykinin B2 receptors do not play important roles in renal wrap hypertension in rabbits. | Clinical and experimental pharmacology & physiology 20011001 |
| Bradykinin receptor antagonists attenuate neointimal proliferation postangioplasty. | American journal of physiology. Heart and circulatory physiology 20011001 |
| Hypoxia decreases lung neprilysin expression and increases pulmonary vascular leak. | American journal of physiology. Lung cellular and molecular physiology 20011001 |
| Age-dependent renal responses to the bradykinin B(2)- receptor antagonist icatibant in conscious lambs. | American journal of physiology. Regulatory, integrative and comparative physiology 20011001 |
| Angiotensin II enhances noradrenaline release from sympathetic nerves of the rat prostate via a novel angiotensin receptor: implications for the pathophysiology of benign prostatic hyperplasia. | The Journal of endocrinology 20011001 |
| Effect of chronic blockade of the kallikrein-kinin system on the development of hypertension in rats. | Hypertension (Dallas, Tex. : 1979) 20011001 |
| Bradykinin facilitates noradrenaline spillover during contraction in the canine gracilis muscle. | Canadian journal of physiology and pharmacology 20011001 |
| Effects of two novel non-peptide antagonists at the rabbit bradykinin B2 receptor. | Peptides 20010901 |
| Apstatin, a selective inhibitor of aminopeptidase P, reduces myocardial infarct size by a kinin-dependent pathway. | British journal of pharmacology 20010901 |
| Angiotensin-(1-7): cardioprotective effect in myocardial ischemia/reperfusion. | Hypertension (Dallas, Tex. : 1979) 20010901 |
| The involvement of bradykinin in adrenaline-induced pulmonary edema in rats. | Journal of medical and dental sciences 20010901 |
| Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom. | Toxicon : official journal of the International Society on Toxinology 20010801 |
| Absence of ligand-induced regulation of kinin receptor expression in the rabbit. | British journal of pharmacology 20010801 |
| Bradykinin B2, but not B1, receptor antagonism has a neuroprotective effect after brain injury. | Journal of neurotrauma 20010801 |
| Bradykinin B2 receptor is involved in the late phase of preconditioning in rabbit heart. | Journal of molecular and cellular cardiology 20010701 |
| Acute effect of the dual angiotensin-converting enzyme and neutral endopeptidase 24-11 inhibitor mixanpril on insulin sensitivity in obese Zucker rat. | British journal of pharmacology 20010601 |
| Plasma extravasation mediated by lipopolysaccharide-induction of kinin B1 receptors in rat tissues. | Mediators of inflammation 20010601 |
| Bradykinin mediates the acute effect of an angiotensin-converting enzyme inhibitor on cerebral autoregulation in rats. | Stroke 20010501 |
| Angiotensin type 1 receptor antagonism and ACE inhibition produce similar renoprotection in N(omega)-nitro-L>-arginine methyl ester/spontaneously hypertensive rats. | Hypertension (Dallas, Tex. : 1979) 20010501 |
| Different potentiating effects of imidapril and enalapril on kaolin-induced writhing reaction in mice. | Life sciences 20010413 |
| Effects of bradykinin on renal nerve stimulation-induced antidiuresis and norepinephrine overflow in anesthetized dogs. | Journal of cardiovascular pharmacology 20010401 |
| Enhanced vascular permeability in solid tumor involving peroxynitrite and matrix metalloproteinases. | Japanese journal of cancer research : Gann 20010401 |
| Decreased flow-dependent dilation in carotid arteries of tissue kallikrein-knockout mice. | Circulation research 20010330 |
| Effects of converting enzyme inhibitors on renal P-450 metabolism of arachidonic acid. | American journal of physiology. Regulatory, integrative and comparative physiology 20010301 |
| Ace-inhibition with quinapril modulates the nitric oxide pathway in normotensive rats. | Journal of molecular and cellular cardiology 20010301 |
| Differences between peptide and nonpeptide B(2) bradykinin receptor antagonists in blocking bronchoconstriction and hypotension induced by bradykinin in anesthetized Guinea pigs. | The Journal of pharmacology and experimental therapeutics 20010301 |
| Effects of icatibant on the ramipril-induced decreased in renal lithium clearance in the rat. | Naunyn-Schmiedeberg's archives of pharmacology 20010301 |
| Bradykinin evokes a Ca2+-activated chloride current in non-neuronal cells isolated from neonatal rat dorsal root ganglia. | The Journal of physiology 20010201 |
| Potentiation of bradykinin by angiotensin-(1-7) on arterioles of spontaneously hypertensive rats studied in vivo. | Hypertension (Dallas, Tex. : 1979) 20010201 |
| Role of bradykinin and tachykinins in the potentiation by enalapril of coughing induced by citric acid in pigs. | Fundamental & clinical pharmacology 20010201 |
| Postischemic anti-inflammatory effects of bradykinin preconditioning. | American journal of physiology. Heart and circulatory physiology 20010101 |
| Role of kinins in seasonal allergic rhinitis: icatibant, a bradykinin B2 receptor antagonist, abolishes the hyperresponsiveness and nasal eosinophilia induced by antigen. | The Journal of allergy and clinical immunology 20010101 |
| Effect of bradykinin on cultured bovine corneal endothelial cells. | Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20010101 |
| Enalaprilat attenuates ischemic rises in intracellular sodium in the isolated rat heart via the bradykinin receptor. | Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20010101 |
| The effect of agonists and antagonists on the morphology of non-transformed human smooth muscle cell in vitro. | Journal of submicroscopic cytology and pathology 20010101 |
| Benidipine, a long-acting Ca channel blocker, limits infarct size via bradykinin- and NO-dependent mechanisms in canine hearts. | Cardiovascular drugs and therapy 20010101 |
| Peptide and non-peptide bradykinin B2 receptor agonists and antagonists: a reappraisal of their pharmacology in the guinea-pig ileum. | European journal of pharmacology 20001208 |
| In various tumour cell lines the peptide bradykinin B(2) receptor antagonist, Hoe 140 (Icatibant), may act as mitogenic agonist. | British journal of pharmacology 20001201 |
| Endogenous bradykinin and the renin and pressor responses to furosemide in humans. | The Journal of pharmacology and experimental therapeutics 20001101 |
| Comparison of enalapril and valsartan in cyclosporine A-induced hypertension and nephrotoxicity in spontaneously hypertensive rats on high-sodium diet. | British journal of pharmacology 20000701 |
| Neuropeptide Y enhances potassium excretion by mechanisms distinct from those controlling sodium excretion. | Canadian journal of physiology and pharmacology 20000201 |
| Characterization of bradykinin B(2) receptor antagonists in human and rat urinary bladder. | European journal of pharmacology 20000128 |
| Design and synthesis of potent bradykinin agonists containing a benzothiazepine moiety. | Journal of medicinal chemistry 19991007 |
| Pharmacological and molecular evidence for kinin B1 receptor expression in urinary bladder of cyclophosphamide-treated rats. | British journal of pharmacology 19990901 |
| Synergy of amlodipine and angiotensin-converting enzyme inhibitors in regulating myocardial oxygen consumption in normal canine and failing human hearts. | The American journal of cardiology 19990617 |
| Acute ACE inhibition causes plasma extravasation in mice that is mediated by bradykinin and substance P. | Hypertension (Dallas, Tex. : 1979) 19980601 |
| Role of kinins in the renoprotective effect of angiotensin-converting enzyme inhibitors in experimental chronic renal failure. | Kidney & blood pressure research 19980101 |
| FR 173657: a new, potent, nonpeptide kinin B2 receptor antagonist. An in vitro study. | Hypertension (Dallas, Tex. : 1979) 19970401 |
| Role of activation of bradykinin B2 receptors in disruption of the blood-brain barrier during acute hypertension. | Brain research 19961104 |
| The role of endogenous bradykinin in blood pressure homeostasis in spontaneously hypertensive rats. | British journal of pharmacology 19960801 |
| Substance P and capsaicin-induced mechanical hyperalgesia in the rat knee joint; the involvement of bradykinin B1 and B2 receptors. | British journal of pharmacology 19960801 |
| Ramiprilat attenuates hypoxia/reoxygenation injury to cardiac myocytes via a bradykinin-dependent mechanism. | European journal of pharmacology 19960613 |
| Cardiac growth during high and low dose perindopril treatment in spontaneously hypertensive rats. | Clinical and experimental pharmacology & physiology 19960101 |
| Kinin and angiotensin II receptor antagonists in rats with chronic renal failure: chronic effects on cardio- and renoprotection of angiotensin converting enzyme inhibitors. | Journal of hypertension 19951201 |
| Nitric oxide and prostaglandins in the prolonged effects of losartan and ramipril in hypertension. | Hypertension (Dallas, Tex. : 1979) 19950801 |
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