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Home > Nitro Compounds > 13010-20-3
13010-20-3 | Urea, N-nitroso-
CAS No: 13010-20-3 Catalog No: AG000U0W MDL No:
Product Description
Catalog Number:
AG000U0W
Chemical Name:
Urea, N-nitroso-
CAS Number:
13010-20-3
Molecular Formula:
CH3N3O2
Molecular Weight:
89.0534
IUPAC Name:
nitrosourea
InChI:
InChI=1S/CH3N3O2/c2-1(5)3-4-6/h(H3,2,3,5,6)
InChI Key:
OSTGTTZJOCZWJG-UHFFFAOYSA-N
SMILES:
O=NNC(=O)N
UNII:
S0W1V6314Y
Properties
Complexity:
69.2
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
89.023g/mol
Formal Charge:
0
Heavy Atom Count:
6
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
89.054g/mol
Monoisotopic Mass:
89.023g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
84.6A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.8
Literature
| Title | Journal |
|---|---|
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| Ipilimumab with fotemustine in metastatic melanoma. | The Lancet. Oncology 20120901 |
| Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines. | Molecular cell 20120713 |
| Management of adverse side-effects after chemotherapy in macaques as exemplified by streptozotocin: case studies and recommendations. | Laboratory animals 20120701 |
| A mutation in the cdh23 gene causes age-related hearing loss in Cdh23(nmf308/nmf308) mice. | Gene 20120515 |
| Dose dense 1 week on/1 week off temozolomide in recurrent glioma: a retrospective study. | Journal of neuro-oncology 20120501 |
| Alternative chemotherapeutic agents: nitrosoureas, cisplatin, irinotecan. | Neurosurgery clinics of North America 20120401 |
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| Adult T-cell leukemia-lymphoma. | Hematology (Amsterdam, Netherlands) 20120401 |
| Anticancer agents for treatment of tumors in the central nervous system by correspondent substituent substitution and elucidation by pattern recognition methods. | Medicinal chemistry (Shariqah (United Arab Emirates)) 20120301 |
| Twice-daily dosing of temozolomide in combination with fotemustine for the treatment of patients with refractory glioblastoma. | Anticancer research 20120301 |
| [Retrospective analysis of 24 recurrent glioblastoma after chemoradiation and treated with nitrosoureas or irinotecan and bevacizumab]. | Bulletin du cancer 20120201 |
| Low-dose fractionated radiotherapy and concomitant chemotherapy in glioblastoma multiforme with poor prognosis: a feasibility study. | Neuro-oncology 20120101 |
| The diabetic heart: too sweet for its own good? | Cardiology research and practice 20120101 |
| Subgroup economic analysis for glioblastoma in a health resource-limited setting. | PloS one 20120101 |
| A retrospective pooled analysis of response patterns and risk factors in recurrent malignant glioma patients receiving a nitrosourea-based chemotherapy. | Journal of translational medicine 20120101 |
| Valproic acid downregulates the expression of MGMT and sensitizes temozolomide-resistant glioma cells. | Journal of biomedicine & biotechnology 20120101 |
| The Risk of Therapy-Related Myelodysplasia/Acute Myeloid Leukemia in Hodgkin Lymphoma has Substantially Decreased in the ABVD Era Abolishing Mechlorethamine and Procarbazine and Limiting Volumes and Doses of Radiotherapy. | Mediterranean journal of hematology and infectious diseases 20120101 |
| Efficacy and safety of the third-generation chloroethylnitrosourea fotemustine for the treatment of chemorefractory T-cell lymphomas. | European journal of haematology 20111201 |
| Fotemustine for the treatment of melanoma. | Expert opinion on pharmacotherapy 20111201 |
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| Initial experience with hepatic intraarterial fotemustine and interferon alpha 2b combination for treatment of liver tumors. | Anticancer research 20111201 |
| Complete response induced by fotemustine given as single agent in a patient with primary central nervous system non-Hodgkin aggressive lymphoma relapsed after high-dose chemotherapy and autologous stem cell support. | Leukemia & lymphoma 20111101 |
| Endothelin-induced changes in blood flow in STZ-diabetic and non-diabetic rats: relation to nitric oxide synthase and cyclooxygenase inhibition. | The journal of physiological sciences : JPS 20111101 |
| Lecture: fotemustine in brain tumors. | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20111101 |
| Ranimustine, ifosfamide, procarbazine, dexamethasone, and etoposide therapy for central nervous system recurrence of diffuse large B-cell lymphoma in patients with poor performance status: a pilot study. | Leukemia & lymphoma 20111001 |
| Liver metastases from melanoma: hepatic intra-arterial chemotherapy. A retrospective study. | Journal of chemotherapy (Florence, Italy) 20111001 |
| Impact of therapy on quality of life, neurocognitive function and their correlates in glioblastoma multiforme: a review. | Journal of neuro-oncology 20110901 |
| Identifying an indoor air exposure limit for formaldehyde considering both irritation and cancer hazards. | Critical reviews in toxicology 20110901 |
| Potential role of melatonin in DNA damage caused by nitrosourea-induced mammary carcinogenesis. | Acta histochemica 20110701 |
| Safety and efficacy of high-dose ranimustine, cytarabine, etoposide and CY (MCVAC) regimen followed by autologous peripheral blood stem cell transplantation for high-risk diffuse large B-cell lymphoma. | Bone marrow transplantation 20110701 |
| A new schedule of fotemustine in temozolomide-pretreated patients with relapsing glioblastoma. | Journal of neuro-oncology 20110501 |
| Cisplatin, fotemustine and whole-brain radiotherapy in non-small cell lung cancer patients with asymptomatic brain metastases: a multicenter phase II study of the Gruppo Oncologico Italia Meridionale (GOIM 2603). | Lung cancer (Amsterdam, Netherlands) 20110401 |
| Phase I and pharmacologic study of BNP7787, a novel chemoprotector in patients with advanced non-small cell lung cancer. | Cancer chemotherapy and pharmacology 20110301 |
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| NPHP4 is necessary for normal photoreceptor ribbon synapse maintenance and outer segment formation, and for sperm development. | Human molecular genetics 20110201 |
| Proton inactivation of melanoma cells enhanced by fotemustine. | Radiation protection dosimetry 20110201 |
| Prefoldin 5 is required for normal sensory and neuronal development in a murine model. | The Journal of biological chemistry 20110107 |
| In Vivo Anti-Diabetic Activity of the Ethanolic Crude Extract of Sorbus decora C.K.Schneid. (Rosacea): A Medicinal Plant Used by Canadian James Bay Cree Nations to Treat Symptoms Related to Diabetes. | Evidence-based complementary and alternative medicine : eCAM 20110101 |
| Pulsatile tinnitus as a first symptom of essential thrombocythemia. | American journal of otolaryngology 20110101 |
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| Streptozotocin is responsible for the induction and progression of renal tumorigenesis in diabetic Wistar-Furth rats treated with insulin or transplanted with agarose encapsulated porcine islets. | Islets 20110101 |
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| Nitrosourea chemotherapeutic agents: 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea. | Report on carcinogens : carcinogen profiles 20110101 |
| Nitrosourea chemotherapeutic agents: 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea. | Report on carcinogens : carcinogen profiles 20110101 |
| Nitrosourea chemotherapeutic agents: Chlorozotocin. | Report on carcinogens : carcinogen profiles 20110101 |
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| Postnatal exposure to N-ethyl-N-nitrosurea disrupts the subventricular zone in adult rodents. | The European journal of neuroscience 20101201 |
| Low-dose fotemustine for recurrent malignant glioma: a multicenter phase II study. | Journal of neuro-oncology 20101101 |
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| Molecular diagnostics of gliomas: state of the art. | Acta neuropathologica 20101101 |
| A nonradiation-containing, intermediate-dose methotrexate regimen for elderly patients with primary central nervous system lymphoma. | International journal of hematology 20101101 |
| Chemotherapy: Lo and behold, a role for lomustine in acute myeloid leukemia? | Nature reviews. Clinical oncology 20101101 |
| Role of differential signaling pathways and oxidative stress in diabetic cardiomyopathy. | Current cardiology reviews 20101101 |
| Phase II TPDCV protocol for pediatric low-grade hypothalamic/chiasmatic gliomas: 15-year update. | Journal of neuro-oncology 20101001 |
| Brain metastasis in melanoma: clinical activity of CTLA-4 antibody therapy. | Seminars in oncology 20101001 |
| Selection of genetically modified hematopoietic cells in vitro and in vivo using alkylating agent lysomustine. | Analytical biochemistry 20100915 |
| Meningioma mouse models. | Journal of neuro-oncology 20100901 |
| Effect of alternative temozolomide schedules on glioblastoma O(6)-methylguanine-DNA methyltransferase activity and survival. | British journal of cancer 20100810 |
| Fotemustine plus etoposide, cytarabine and melphalan (FEAM) as a new conditioning regimen for lymphoma patients undergoing auto-SCT: a multicenter feasibility study. | Bone marrow transplantation 20100701 |
| Animal models for retinitis pigmentosa induced by MNU; disease progression, mechanisms and therapeutic trials. | Histology and histopathology 20100701 |
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| Evaluation of the exposure equivalence of oral versus intravenous temozolomide. | Cancer chemotherapy and pharmacology 20100301 |
| Sequencing analysis of mutations induced by N-ethyl-N-nitrosourea at different sampling times in mouse bone marrow. | Journal of applied toxicology : JAT 20100301 |
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| Multicentre, open, noncomparative Phase II trial to evaluate the efficacy and tolerability of fotemustine, cisplatin, alpha-interferon and interleukin-2 in advanced melanoma patients. | Melanoma research 20090401 |
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| Treatment of recurrent malignant gliomas with fotemustine monotherapy: impact of dose and correlation with MGMT promoter methylation. | BMC cancer 20090101 |
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| Streptozotocin, type I diabetes severity and bone. | Biological procedures online 20090101 |
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| Teaching molecular genetics: chapter 4-positional cloning of genetic disorders. | Pediatric nephrology (Berlin, Germany) 20071201 |
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| Evaluation of dimethoxydop-NU as a novel anti-tumor agent. | Journal of experimental & clinical cancer research : CR 20071201 |
| Management of patients with newly diagnosed malignant primary brain tumors with a focus on the evolving role of temozolomide. | Therapeutics and clinical risk management 20071201 |
| Impressive objective response in a patient with extensive metastatic melanoma including the brain. | Melanoma research 20071001 |
| Long-term survival and secondary acute leukemia after fotemustine therapy for metastatic melanoma. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20071001 |
| Interstitial chemotherapy with biodegradable BCNU (Gliadel) wafers in the treatment of malignant gliomas. | Therapeutics and clinical risk management 20071001 |
| Novel mechanism whereby nuclear factor kappaB mediates DNA damage repair through regulation of O(6)-methylguanine-DNA-methyltransferase. | Cancer research 20070915 |
| Specific mTOR inhibitor rapamycin enhances cytotoxicity induced by alkylating agent 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea (ACNU) in human U251 malignant glioma cells. | Journal of neuro-oncology 20070901 |
| Interventional management of gastroduodenal lesions complicating intra-arterial hepatic chemotherapy. | European radiology 20070801 |
| Screening for ENU-induced mutations in mice that result in aberrant ethanol-related phenotypes. | Behavioral neuroscience 20070801 |
| The economics of temozolomide in brain cancer. | Expert opinion on pharmacotherapy 20070801 |
| A phase I and pharmacokinetic study of NK105, a paclitaxel-incorporating micellar nanoparticle formulation. | British journal of cancer 20070716 |
| Ependymoma. | Critical reviews in oncology/hematology 20070701 |
| Hepatic arterial Fotemustine chemotherapy in patients with liver metastases from cutaneous melanoma is as effective as in ocular melanoma. | European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 20070601 |
| Reappraisal of the use of procarbazine in the treatment of lymphomas and brain tumors. | Therapeutics and clinical risk management 20070601 |
| Assessing cumulative health risks from exposure to environmental mixtures - three fundamental questions. | Environmental health perspectives 20070501 |
| The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas. | Journal of the National Cancer Institute 20070418 |
| Safety and efficacy of convection-enhanced delivery of ACNU, a hydrophilic nitrosourea, in intracranial brain tumor models. | Journal of neuro-oncology 20070301 |
| Metabolomics by proton nuclear magnetic resonance spectroscopy of the response to chloroethylnitrosourea reveals drug efficacy and tumor adaptive metabolic pathways. | Cancer research 20070301 |
| A phase I/II study of lomustine and temozolomide in patients with cerebral metastases from malignant melanoma. | British journal of cancer 20070115 |
| Structural basis for the adherence of Plasmodium falciparum-infected erythrocytes to chondroitin 4-sulfate and design of novel photoactivable reagents for the identification of parasite adhesive proteins. | The Journal of biological chemistry 20070112 |
| The combi-targeting concept: in vitro and in vivo fragmentation of a stable combi-nitrosourea engineered to interact with the epidermal growth factor receptor while remaining DNA reactive. | Clinical cancer research : an official journal of the American Association for Cancer Research 20070101 |
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| Comparison of new nitrosoureas esters with modified steroidal nucleus for cytogenetic and antineoplastic activity. | In vivo (Athens, Greece) 20070101 |
| Short interfering RNA directed against the SLUG gene increases cell death induction in human melanoma cell lines exposed to cisplatin and fotemustine. | Cellular oncology : the official journal of the International Society for Cellular Oncology 20070101 |
| Synthesis and evaluation of ethylnitrosoureas of substituted naphthalimides as anticancer compounds. | Acta poloniae pharmaceutica 20070101 |
| Nitrosoureas: molecular pharmacology/ translational research. | Tumori 20070101 |
| Medical treatment and other combination regimens. | Tumori 20070101 |
| Medical treatment of uveal melanoma. | Tumori 20070101 |
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| Focus on Fotemustine. | Journal of experimental & clinical cancer research : CR 20061201 |
| A phase I study of pemetrexed (LY231514) supplemented with folate and vitamin B12 in Japanese patients with solid tumours. | British journal of cancer 20060918 |
| Xrcc2 deficiency sensitizes cells to apoptosis by MNNG and the alkylating anticancer drugs temozolomide, fotemustine and mafosfamide. | Cancer letters 20060808 |
| Cystemustine in recurrent high grade glioma. | Journal of neuro-oncology 20060801 |
| Preliminary individualized chemotherapy for malignant astrocytomas based on O6-methylguanine-deoxyribonucleic acid methyltransferase methylation analysis. | Neurologia medico-chirurgica 20060801 |
| Liver protein synthesis stays elevated after chemotherapy in tumour-bearing mice. | Cancer letters 20060728 |
| Predicting and monitoring response to chemotherapy by 1,3-bis(2-chloroethyl)-1-nitrosourea in subcutaneously implanted 9L glioma using the apparent diffusion coefficient of water and 23Na MRI. | Journal of magnetic resonance imaging : JMRI 20060701 |
| [Glioma]. | Nihon rinsho. Japanese journal of clinical medicine 20060701 |
| The combi-targeting concept: synthesis of stable nitrosoureas designed to inhibit the epidermal growth factor receptor (EGFR). | Journal of medicinal chemistry 20060615 |
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| The role of chemotherapy in the treatment of malignant astrocytomas. | The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20060501 |
| Intra-arterial hepatic fotemustine for the treatment of liver metastases from uveal melanoma: experience in 101 patients. | Annals of oncology : official journal of the European Society for Medical Oncology 20060401 |
| Thalidomide for the treatment of leptomeningeal multiple myeloma. | European journal of haematology 20060401 |
| O(6)-methylguanine DNA-methyltransferase (MGMT) overexpression in melanoma cells induces resistance to nitrosoureas and temozolomide but sensitizes to mitomycin C. | Toxicology and applied pharmacology 20060301 |
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| Mitochondrial DNA mutations in renal cell carcinomas revealed no general impact on energy metabolism. | British journal of cancer 20060130 |
| Novel strategies for the development of animal models of refractory epilepsy. | Advances in neurology 20060101 |
| Phase I study of intermittent and chronomodulated oral therapy with capecitabine in patients with advanced and/or metastatic cancer. | BMC cancer 20060101 |
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| Integration of chemotherapy into current treatment strategies for brain metastases from solid tumors. | Radiation oncology (London, England) 20060101 |
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| Genotoxic effects induced by fotemustine and vinorelbine in human lymphocytes. | Zeitschrift fur Naturforschung. C, Journal of biosciences 20060101 |
| Phase II trial of SarCNU in malignant glioma: unexpected pulmonary toxicity with a novel nitrosourea: a phase II trial of the national cancer institute of canada clinical trials group. | Investigational new drugs 20051201 |
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| Phase I and pharmacological study of the farnesyltransferase inhibitor tipifarnib (Zarnestra, R115777) in combination with gemcitabine and cisplatin in patients with advanced solid tumours. | British journal of cancer 20051128 |
| Second-line chemotherapy of disseminated malignant melanoma with cystemustine at 60 mg/m2: a phase II trial. | Anti-cancer drugs 20051001 |
| Update: current management issues in malignant melanoma. | Melanoma research 20051001 |
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| First-line nitrosourea-based chemotherapy in symptomatic non-resectable supratentorial pure low-grade astrocytomas. | European journal of neurology 20050901 |
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| Quantitation of O6-methylguanine-DNA methyltransferase gene messenger RNA in gliomas by means of real-time RT-PCR and clinical response to nitrosoureas. | Cellular and molecular neurobiology 20050901 |
| A pilot study of bortezomib in Korean patients with relapsed or refractory myeloma. | Journal of Korean medical science 20050801 |
| Beneficial effects of spin-labelled nitrosourea on CCNU-induced oxidative stress in rat blood compared with vitamin E. | Die Pharmazie 20050701 |
| Prolonged survival after resection of liver metastases from uveal melanoma and intra-arterial chemotherapy. | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20050601 |
| Synthesis, DNA binding, topoisomerase inhibition and cytotoxic properties of 2-chloroethylnitrosourea derivatives of hoechst 33258. | Biological & pharmaceutical bulletin 20050601 |
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| [Progress of the ATLL study: an overview]. | [Rinsho ketsueki] The Japanese journal of clinical hematology 20050501 |
| A phase II study of concurrent temozolomide and cis-retinoic acid with radiation for adult patients with newly diagnosed supratentorial glioblastoma. | International journal of radiation oncology, biology, physics 20050401 |
| [Nitric oxide in malignant astrocytes]. | Revista de neurologia 20050401 |
| [Resent advances in chemotherapy for malignant brain tumors]. | Gan to kagaku ryoho. Cancer & chemotherapy 20050401 |
| A phase I clinical and pharmacokinetic study of capecitabine (Xeloda) and irinotecan combination therapy (XELIRI) in patients with metastatic gastrointestinal tumours. | British journal of cancer 20050314 |
| Promoter hypermethylation of mismatch repair gene hMLH1 predicts the clinical response of malignant astrocytomas to nitrosourea. | Clinical cancer research : an official journal of the American Association for Cancer Research 20050215 |
| O6-methylguanine-DNA methyltransferase methylation and TP53 mutation in malignant astrocytomas and their relationships with clinical course. | International journal of cancer 20050210 |
| Polyclonal chemoprotection against temozolomide in a large-animal model of drug resistance gene therapy. | Blood 20050201 |
| Pyrrolidon carboxypeptidase activities in the hypothalamus-pituitary-thyroid and hypothalamus-pituitary-ovary axes of rats with mammary gland cancer induced by N-methyl nitrosourea. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20050201 |
| Neuro-oncology: the growing role of chemotherapy in glioma. | The Lancet. Neurology 20050101 |
| Complete remissions in chemotherapy of lung cancer models induced in mice by asbestos. | The Mount Sinai journal of medicine, New York 20050101 |
| Photodynamic treatment with fractionated light decreases production of reactive oxygen species and cytotoxicity in vitro via regeneration of glutathione. | Photochemistry and photobiology 20050101 |
| [Combined treatment of glyal and metastatic tumors of the brain]. | Vestnik khirurgii imeni I. I. Grekova 20050101 |
| Treatment arms summarizing analysis of 220 high-grade glioma studies. | Anticancer research 20050101 |
| Fundamental roles of reactive oxygen species and protective mechanisms in the female reproductive system. | Reproductive biology and endocrinology : RB&E 20050101 |
| [Experience with use of mustoforan at the Clinical Oncological Dispensary of the Republic of Tatarstan]. | Voprosy onkologii 20050101 |
| Long-term disease-free survival in advanced melanomas treated with nitrosoureas: mechanisms and new perspectives. | BMC cancer 20050101 |
| [Focal segmental glomerulosclerosis in a patient with polycythemia vera]. | Nihon Jinzo Gakkai shi 20050101 |
| Efficacy and feasibility of procarbazine, ranimustine and vincristine chemotherapy, and the role of surgical resection in anaplastic oligodendroglioma. | Anticancer research 20050101 |
| Influence of geomagnetic activity on mustophoran hematotoxicity. | Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20050101 |
| [Results of hyperfractionated radiation therapy used in combination with lomustin in malignant gliomas of the brain]. | Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko 20050101 |
| [Effectiveness and safety of combined mustoforan, cisplatin and tamoxifen for disseminated cutaneous melanoma (results of the IC4-10036-46-RU trial)]. | Voprosy onkologii 20050101 |
| Isolated limb infusion with fotemustine after dacarbazine chemosensitisation for inoperable loco-regional melanoma recurrence. | European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 20041201 |
| [Combi-molecules: a global approach towards better chemoselectivity and chemosensitivity]. | Bulletin du cancer 20041201 |
| Immunohistochemical study for O6-methylguanine-DNA methyltransferase in the non-neoplastic and neoplastic components of gliomas. | Journal of neuro-oncology 20041201 |
| Temozolomide chemotherapy of patients with recurrent anaplastic astrocytomas and glioblastomas. | Ideggyogyaszati szemle 20041120 |
| Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin. | British journal of cancer 20041115 |
| Inhibition of O6-methylguanine-DNA methyltransferase by glucose-conjugated inhibitors: comparison with nonconjugated inhibitors and effect on fotemustine and temozolomide-induced cell death. | The Journal of pharmacology and experimental therapeutics 20041101 |
| Immunity against mouse thymus-leukemia antigen (TL) protects against development of lymphomas induced by a chemical carcinogen, N-butyl-N-nitrosourea. | Cancer science 20041101 |
| Endothelin-1-induced vasodilatation in rat breast tumor is mediated through endothelin-B receptors. | Journal of cardiovascular pharmacology 20041101 |
| A randomised phase II multicentre trial of irinotecan (CPT-11) using four different schedules in patients with metastatic colorectal cancer. | British journal of cancer 20041018 |
| Phase II study of temozolomide and thalidomide with radiation therapy for newly diagnosed glioblastoma multiforme. | International journal of radiation oncology, biology, physics 20041001 |
| Phase II study of concurrent continuous Temozolomide (TMZ) and Tamoxifen (TMX) for recurrent malignant astrocytic gliomas. | Journal of neuro-oncology 20041001 |
| [CD56-positive peripheral T-cell lymphoma primarily presenting with tonsillar swelling]. | [Rinsho ketsueki] The Japanese journal of clinical hematology 20041001 |
| [Multiple myeloma of the IgD-lambda type invading CNS]. | [Rinsho ketsueki] The Japanese journal of clinical hematology 20041001 |
| Theoretical study of some nitrososulfamide compounds with antitumor activity. | Molecules (Basel, Switzerland) 20040930 |
| The tyrosine kinase inhibitor ZD6474 inhibits tumour growth in an intracerebral rat glioma model. | British journal of cancer 20040913 |
| Phase II trial of carboplatin and etoposide for patients with recurrent high-grade glioma. | British journal of cancer 20040913 |
| Vascular endothelial growth factor (VEGF) in leptomeningeal metastasis: diagnostic and prognostic value. | British journal of cancer 20040719 |
| Preliminary study on pharmacokinetics of dacarbazine and fotemustine in glioblastoma multiforme patients does not indicate gender-specific differences. | Anti-cancer drugs 20040601 |
| High-dose chemotherapy in childhood brain tumors. | Onkologie 20040601 |
| Post-operative sequential chemo-radiotherapy in high-grade cerebral gliomas with fotemustine. | Journal of chemotherapy (Florence, Italy) 20040601 |
| Long-term outcome of oligodendrogliomas. | Neurology 20040525 |
| Dependence of the cytotoxicity of DNA-damaging agents on the mismatch repair status of human cells. | Cancer research 20040515 |
| Prevention of hepatotoxicity but loss of antimelanoma effect with combined fotemustine and anti-oxidant treatment. | Internal medicine journal 20040501 |
| Phase II study of neoadjuvant 1, 3-bis (2-chloroethyl)-1-nitrosourea and temozolomide for newly diagnosed anaplastic glioma: a North American Brain Tumor Consortium Trial. | Cancer 20040415 |
| Glutathione S-transferase polymorphisms and survival in primary malignant glioma. | Clinical cancer research : an official journal of the American Association for Cancer Research 20040415 |
| Inhibition of cell signaling by the combi-nitrosourea FD137 in the androgen independent DU145 prostate cancer cell line. | The Prostate 20040401 |
| Dehydroascorbate influences the plant cell cycle through a glutathione-independent reduction mechanism. | Plant physiology 20040401 |
| Fotemustine compared with dacarbazine in patients with disseminated malignant melanoma: a phase III study. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20040315 |
| Salvage chemotherapy with cyclophosphamide for recurrent, temozolomide-refractory glioblastoma multiforme. | Cancer 20040315 |
| A chemically induced model for squamous cell carcinoma of the lung in mice: histopathology and strain susceptibility. | Cancer research 20040301 |
| A randomized phase I and pharmacological trial of sequences of 1,3-bis(2-chloroethyl)-1-nitrosourea and temozolomide in patients with advanced solid neoplasms. | Clinical cancer research : an official journal of the American Association for Cancer Research 20040301 |
| [Granulocyte-colony stimulating factor-producing myeloma with clinical manifestations mimicking chronic neutrophilic leukemia]. | [Rinsho ketsueki] The Japanese journal of clinical hematology 20040301 |
| [Adult T-cell leukemia/lymphoma of bone with multiple pathological fractures]. | [Rinsho ketsueki] The Japanese journal of clinical hematology 20040301 |
| Monitoring temozolomide treatment of low-grade glioma with proton magnetic resonance spectroscopy. | British journal of cancer 20040223 |
| Phase III study of ranimustine, cyclophosphamide, vincristine, melphalan, and prednisolone (MCNU-COP/MP) versus modified COP/MP in multiple myeloma: a Japan clinical oncology group study, JCOG 9301. | International journal of hematology 20040201 |
| [Therapy of malignant melanoma at the stage of distant metastasis]. | Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20040201 |
| Imaging drug resistance with radiolabeled molecules. | Current pharmaceutical design 20040101 |
| Mitochondrial inhibition of uracil-DNA glycosylase is not mutagenic. | Molecular cancer 20040101 |
| Cardiac lymphoma successfully treated with high dose chemotherapy followed by autologous haematopoietic stem cell transplantation. | Haematologica 20031201 |
| Benefits of adjuvant chemotherapy in high-grade gliomas. | Seminars in oncology 20031201 |
| Cytotoxicity, DNA damage, and apoptosis induced by new fotemustine analogs on human melanoma cells in relation to O6-methylguanine DNA-methyltransferase expression. | The Journal of pharmacology and experimental therapeutics 20031101 |
| Summary version of the Standards, Options and Recommendations for the management of adult patients with intracranial glioma (2002). | British journal of cancer 20030801 |
| Recurrent delayed brain hemorrhage over years after irradiation and chemotherapy for astrocytoma. | European radiology 20030801 |
| Second-line chemotherapy with dacarbazine and fotemustine in nitrosourea-pretreated patients with recurrent glioblastoma multiforme. | Anti-cancer drugs 20030701 |
| Response of melanoma tumor phospholipid metabolism to chloroethyle nitrosourea: a high resolution proton NMR spectroscopy study. | Pathologie-biologie 20030701 |
| Survival improvement in patients with glioblastoma multiforme during the last 20 years in a single tertiary-care center. | Wiener klinische Wochenschrift 20030624 |
| Phase I-II study on isolation antiblastic fotemustine perfusion after dacarbazine chemosensitization for advanced melanoma of the extremities. | Melanoma research 20030601 |
| Rodent models of genetic disease. | Current opinion in genetics & development 20030601 |
| Phase II study of fotemustine in patients with advanced ovarian carcinoma. A trial of the EORTC Gynecological Cancer Group. | European journal of cancer (Oxford, England : 1990) 20030501 |
| Successful high-dose chemotherapy for widespread neuroaxis dissemination of an optico-hypothalamic juvenile pilocytic astrocytoma in an infant: a case report. | Journal of neuro-oncology 20030501 |
| Marked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules. | British journal of cancer 20030407 |
| Reversal of drug resistance mediated by hammerhead ribozyme against multidrug resistance-associated protein 1 in a human glioma cell line. | International journal of oncology 20030401 |
| Clinical and pharmacokinetic phase II study of fotemustine in refractory and relapsing multiple myeloma patients. | Annals of oncology : official journal of the European Society for Medical Oncology 20030401 |
| Relationship between expression of O6-methylguanine-DNA methyltransferase, glutathione-S-transferase pi in glioblastoma and the survival of the patients treated with nimustine hydrochloride: an immunohistochemical analysis. | Neurological research 20030401 |
| Chemotherapy and bio-chemotherapy in patients with advanced melanoma: combination therapy with a nitrosourea. | Journal of chemotherapy (Florence, Italy) 20030401 |
| Nitroxyl radicals and malignant pigment melanoma. | Medical hypotheses 20030301 |
| Topical imiquimod in the treatment of metastatic melanoma to skin. | Archives of dermatology 20030301 |
| The role of human alkyladenine glycosylase in cellular resistance to the chloroethylnitrosoureas. | Carcinogenesis 20030301 |
| Synthesis and biological evaluation of Fotemustine analogues on human melanoma cell lines. | European journal of medicinal chemistry 20030301 |
| Survival with dacarbazine and fotemustine in newly diagnosed glioblastoma multiforme. | British journal of cancer 20030224 |
| Quantitative HRMAS proton total correlation spectroscopy applied to cultured melanoma cells treated by chloroethyl nitrosourea: demonstration of phospholipid metabolism alterations. | Magnetic resonance in medicine 20030201 |
| A prospective randomized multicentre phase III trial of fotemustine plus whole brain irradiation versus fotemustine alone in cerebral metastases of malignant melanoma. | Melanoma research 20030201 |
| [Randomised phase III trial of fotemustine versus fotemustine plus whole brain irradiation in cerebral metastases of melanoma]. | Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique 20030201 |
| SarCNU, a nitrosourea analog on a day 1, 5, and 9 oral schedule: a phase I and pharmacokinetic study in patients with advanced solid tumors. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030115 |
| [Treatment of melanoma]. | Presse medicale (Paris, France : 1983) 20030111 |
| The combi-targeting concept: a novel 3,3-disubstituted nitrosourea with EGFR tyrosine kinase inhibitory properties. | Cancer chemotherapy and pharmacology 20030101 |
| Science review: key inflammatory and stress pathways in critical illness - the central role of the Toll-like receptors. | Critical care (London, England) 20030101 |
| Chemotherapy for high-grade glioma. | Neuroepidemiology 20030101 |
| Recombinant mutant human tumor necrosis factor-alpha (TNF-SAM2) immunotherapy with ranimustine chemotherapy and concurrent radiation therapy for malignant astrocytomas. | Anticancer research 20030101 |
| Combination chemotherapy of ranimustine, doxorubicine, and dexamethasone for relapsing multiple myeloma--a pilot study. | Journal of medicine 20030101 |
| Recurrent malignant glioma in adults. | Current treatment options in oncology 20021201 |
| Candidate genes for cross-resistance against DNA-damaging drugs. | Cancer research 20021115 |
| Megakaryoblastic transformation of polycythemia vera with hypercalcemia. | Annals of hematology 20021101 |
| [Therapeutic effectiveness of ranimustine chemotherapy for essential thrombocythemia in the elderly]. | Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 20021101 |
| Treatment of paediatric pontine glioma with oral trophosphamide and etoposide. | British journal of cancer 20021021 |
| Treatment of disseminated ocular melanoma with sequential fotemustine, interferon alpha, and interleukin 2. | British journal of cancer 20021007 |
| Inhibition of O6-alkylguanine-DNA alkyltransferase by O6-benzyl-N2-acetylguanosine increases chloroethylnitrosourea-induced apoptosis in Mer+ human melanoma cells. | Melanoma research 20021001 |
| Systemic chemotherapy for the treatment of metastatic melanoma. | Seminars in oncology 20021001 |
| Metastatic melanoma: chemotherapy. | Seminars in oncology 20021001 |
| The treatment of brain metastases from malignant melanoma. | Seminars in oncology 20021001 |
| Phase I study of fotemustine in pediatric patients with refractory brain tumors. | Cancer 20020915 |
| A phase I and pharmacokinetic study of MAG-CPT, a water-soluble polymer conjugate of camptothecin. | British journal of cancer 20020909 |
| Modulation of growth and radiochemosensitivity of human malignant glioma cells by acidosis. | Cancer 20020901 |
| Histological and MR correlations in Gliomatosis cerebri. | Journal of neuro-oncology 20020901 |
| O6-benzylguanine-mediated enhancement of chemotherapy. | Molecular cancer therapeutics 20020901 |
| Superoxide activates constitutive nitric oxide synthase in a brain particulate fraction. | Biochemical and biophysical research communications 20020816 |
| Treatment of advanced neuroendocrine tumours using combination chemotherapy with lomustine and 5-fluorouracil. | Clinical endocrinology 20020801 |
| Severe neurological disabilities after complete remission of advanced malignant melanoma following fotemustine therapy in combination with total brain irradiation. | Melanoma research 20020801 |
| Isolated limb perfusion in locally advanced cutaneous melanoma. | Seminars in oncology 20020801 |
| Evaluation of the efficiency of chemotherapy in in vivo orthotopic models of human glioma cells with and without 1p19q deletions and in C6 rat orthotopic allografts serving for the evaluation of surgery combined with chemotherapy. | Cancer 20020801 |
| Chemotherapy inhibits skeletal muscle ubiquitin-proteasome-dependent proteolysis. | Cancer research 20020515 |
| Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020501 |
| Pharmacokinetic study of cystemustine, administered on a weekly schedule in cancer patients. | Annals of oncology : official journal of the European Society for Medical Oncology 20020501 |
| Null association between frequency of cured meat consumption and methylvaline and ethylvaline hemoglobin adduct levels: the N-nitroso brain cancer hypothesis. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20020401 |
| Structure-based design of nitrosoureas containing tyrosine derivatives as potential antimelanoma agents. | European journal of medicinal chemistry 20020401 |
| Superior efficacy of MMCP regimen compared with VMCP and MMPP regimens in the treatment of multiple myeloma. | Internal medicine (Tokyo, Japan) 20020401 |
| Melanoma tumors acquire a new phospholipid metabolism phenotype under cystemustine as revealed by high-resolution magic angle spinning proton nuclear magnetic resonance spectroscopy of intact tumor samples. | Cancer research 20020315 |
| A rapid and systematic review of the effectiveness of temozolomide for the treatment of recurrent malignant glioma. | British journal of cancer 20020212 |
| Reversible restrictive cardiomyopathy due to light-chain deposition disease. | Mayo Clinic proceedings 20020201 |
| Enhancement of fotemustine (Muphoran) cytotoxicity by amifostine in malignant melanoma cell lines. | Anti-cancer drugs 20020201 |
| Leukemic transformation with trisomy 8 in essential thrombocythemia: a report of four cases. | European journal of haematology 20020201 |
| Cell killing of melanoma B16 in vivo by hyperthermia and cytotoxins. | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20020101 |
| Fatal hemorrhage after radiochemotherapy for leptomeningeal dissemination of glioma: report of two cases. | Surgical neurology 20020101 |
| Therapy-related myelodysplastic syndrome in a case of cutaneous adult T-cell lymphoma. | International journal of hematology 20020101 |
| Local interstitial chemotherapy with sustained release bucladesine in de novo glioblastoma multiforme: a preliminary study. | Journal of neuro-oncology 20020101 |
| Comparative cytotoxicity of carmustine (BCNU), nimustine (ACNU) and elmustine (HeCNU) after depletion of O6-alkylguanine-DNA alkyltransferase (O6-AGT). | Anticancer research 20020101 |
| Interferon-alpha therapy following autologous peripheral blood stem cell transplantation for adult T cell leukemia/lymphoma. | Acta haematologica 20020101 |
| Pharmacokinetics of the carmustine implant. | Clinical pharmacokinetics 20020101 |
| Adenoviral transfer of antisenses or ribozyme to O6-methylguanine-DNA methyltransferase mRNA in brain-tumor model resistant to chloroethyl-nitrosourea. | Anticancer research 20020101 |
| Treatment of recurrent malignant supratentorial astrocytomas with carboplatin and etoposide combined with recombinant mutant human tumor necrosis factor-alpha. | Anticancer research 20020101 |
| Temozolomide in patients with glioblastoma at second relapse after first line nitrosourea-procarbazine failure: a phase II study. | Oncology 20020101 |
| Different mutation status of the beta-catenin gene in carcinogen-induced colon, brain, and oral tumors in rats. | Molecular carcinogenesis 20011201 |
| Diva/Boo is a negative regulator of cell death in human glioma cells. | FEBS letters 20010907 |
| Nitric oxide and free stable nitroxyl radicals in the mechanism of biological action of the spin-labeled compounds. | Medical hypotheses 20010901 |
| Plasma pharmacokinetics and bioavailability of 1-(2-chloroethyl)-3-sarcosinamide-1-nitrosourea after intravenous and oral administration to mice and dogs. | Cancer chemotherapy and pharmacology 20010901 |
| Two glycine containing 2-chloroethylnitrosoureas--a comparative study on some physicochemical properties, in vivo antimelanomic effects and immunomodulatory properties. | International journal of pharmaceutics 20010717 |
| Detection of human herpesvirus 6 and JC virus in progressive multifocal leukoencephalopathy complicating follicular lymphoma. | American journal of hematology 20010701 |
| Higher skeletal muscle protein synthesis and lower breakdown after chemotherapy in cachectic mice. | American journal of physiology. Regulatory, integrative and comparative physiology 20010701 |
| Differences in sensitivity of murine spermatogonia and somatic cells in vivo to sister-chromatid exchange induction by nitrosoureas. | Mutation research 20010701 |
| Neurofibromatosis type 1-associated unusual pleomorphic astrocytoma displaying continual malignant progression. | Pathology international 20010701 |
| Clinical benefits of lenograstim in patients with neutropenia due to chemotherapy for multiple myeloma (MM). | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20010701 |
| Synthesis of polycyclic guanidines by cyclocondensation reactions of N-amidinyliminium ions. | The Journal of organic chemistry 20010504 |
| A new G-CSF-supported combination chemotherapy, LSG15, for adult T-cell leukaemia-lymphoma: Japan Clinical Oncology Group Study 9303. | British journal of haematology 20010501 |
| Drug delivery to tumors of the central nervous system. | Current neurology and neuroscience reports 20010501 |
| Acquired resistance of melanoma cells to the antineoplastic agent fotemustine is caused by reactivation of the DNA repair gene MGMT. | International journal of cancer 20010401 |
| Fotemustine combined with procarbazine in recurrent malignant gliomas: a phase I study with evaluation of lymphocyte 06-alkylguanine-DNA alkyltransferase activity. | Journal of neuro-oncology 20010401 |
| Cystemustine induces redifferentiation of primary tumors and confers protection against secondary tumor growth in a melanoma murine model. | Cancer research 20010301 |
| Efficacy of adjuvant therapy with procarbazine, MCNU, and vincristine for oligodendroglial tumors. | Neurologia medico-chirurgica 20010301 |
| Involvement of the multidrug resistance protein 3 in drug sensitivity and its expression in human glioma. | Japanese journal of cancer research : Gann 20010201 |
| [Therapy of metastatic malignant uveal melanoma]. | Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20010201 |
| Nitroso-urea-cisplatin-based chemotherapy associated with valproate: increase of haematologic toxicity. | Annals of oncology : official journal of the European Society for Medical Oncology 20010201 |
| Temozolomide as a second-line systemic regimen in recurrent high-grade glioma: a phase II study. | Annals of oncology : official journal of the European Society for Medical Oncology 20010201 |
| Pilot study of hepatic intraarterial fotemustine chemotherapy for liver metastases from uveal melanoma: a single-center experience with seven patients. | International journal of clinical oncology 20010201 |
| Spin labelled nitrosoureas and triazenes and their non-labelled clinically used analogues--a comparative study on their physicochemical properties and antimelanomic effects. | International journal of pharmaceutics 20010116 |
| Planning of hyperthermic treatment for malignant glioma using computer simulation. | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20010101 |
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| Spin-labeled 1-alkyl-1-nitrosourea synergists of antitumor antibiotics. | Anti-cancer drug design 20010101 |
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