200,000+ products from a single source!
sales@angenechem.com
130018-77-8 | Acetic acid, 2-[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-
CAS No: 130018-77-8 Catalog No: AG000TX4 MDL No:
Product Description
Catalog Number:
AG000TX4
Chemical Name:
Acetic acid, 2-[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-
CAS Number:
130018-77-8
Molecular Formula:
C21H25ClN2O3
Molecular Weight:
388.8878
IUPAC Name:
2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid
InChI:
InChI=1S/C21H25ClN2O3/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26/h1-9,21H,10-16H2,(H,25,26)/t21-/m1/s1
InChI Key:
ZKLPARSLTMPFCP-OAQYLSRUSA-N
SMILES:
OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1
UNII:
6U5EA9RT2O
Properties
Complexity:
443
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
1
Defined Bond Stereocenter Count:
0
Exact Mass:
388.155g/mol
Formal Charge:
0
Heavy Atom Count:
27
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
388.892g/mol
Monoisotopic Mass:
388.155g/mol
Rotatable Bond Count:
8
Topological Polar Surface Area:
53A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.7
Literature
| Title | Journal |
|---|---|
| Histamine H4 and H1 receptors contribute to postinflammatory visceral hypersensitivity. | Gut 20141201 |
| Chitosan-based thermosensitive hydrogel as a promising ocular drug delivery system: preparation, characterization, and in vivo evaluation. | Journal of biomaterials applications 20121101 |
| Safety profile of enantiomers vs. racemic mixtures: it's the same? | British journal of clinical pharmacology 20121101 |
| H(1)-antihistamines and urticaria: how can we predict the best drug for our patient? | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20121001 |
| A trial of adding Lactobacillus johnsonii EM1 to levocetirizine for treatment of perennial allergic rhinitis in children aged 7-12 years. | International journal of pediatric otorhinolaryngology 20120701 |
| Bilastine: in allergic rhinitis and urticaria. | Drugs 20120618 |
| Development of a validated capillary electrophoresis method for enantiomeric purity control and quality control of levocetirizine in a pharmaceutical formulation. | Chirality 20120401 |
| Management of chronic urticaria in Asia: 2010 AADV consensus guidelines. | Asia Pacific allergy 20120401 |
| Predicting psychopharmacological drug effects on actual driving performance (SDLP) from psychometric tests measuring driving-related skills. | Psychopharmacology 20120301 |
| Drivers can poorly predict their own driving impairment: a comparison between measurements of subjective and objective driving quality. | Psychopharmacology 20120201 |
| Induction of specific immunotherapy with hymenoptera venoms using ultrarush regimen in children: safety and tolerance. | Journal of allergy 20120101 |
| Effects of acupuncture and moxibustion in a mouse model of allergic rhinitis. | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20120101 |
| Levocetirizine inhibits rhinovirus-induced bacterial adhesion to nasal epithelial cells through down-regulation of cell adhesion molecules. | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20120101 |
| The loss of smell in persistent allergic rhinitis is improved by levocetirizine due to reduction of nasal inflammation but not nasal congestion (the CIRANO study). | International archives of allergy and immunology 20120101 |
| Adoption of new drugs by physicians: a survival analysis. | BMC health services research 20120101 |
| Complete right lung agenesis presenting with bronchial asthma and allergic rhinitis. | BMJ case reports 20120101 |
| Development and characterization of pharmacokinetic parameters of fast-dissolving films containing levocetirizine. | Scientia pharmaceutica 20120101 |
| Simultaneous determination of levocetirizine and pseudoephedrine in dog plasma by liquid chromatography-mass spectrometry in the presence of dextrocetirizine. | Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20120101 |
| The effectiveness of levocetirizine in comparison with loratadine in treatment of allergic rhinitis--a meta-analysis. | Allergology international : official journal of the Japanese Society of Allergology 20111201 |
| Second-generation H1-antihistamines in chronic urticaria: an evidence-based review. | American journal of clinical dermatology 20111201 |
| Examining the utilization and tolerability of the non-sedating antihistamine levocetirizine in England using prescription-event monitoring data. | Drug safety 20111201 |
| Comparison of the sedating effects of levocetirizine and cetirizine: a randomized, double-blind, placebo-controlled trial. | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20111201 |
| Rupatadine and levocetirizine in chronic idiopathic urticaria: a comparative study of efficacy and safety. | Journal of drugs in dermatology : JDD 20111201 |
| Fexofenadine-induced urticaria. | Annals of dermatology 20111201 |
| Annular leukocytoclastic vasculitis in a patient with ulcerative colitis. | Annals of dermatology 20111201 |
| Efficacy of second-generation antihistamines in patients with allergic rhinitis and comorbid asthma. | The Journal of asthma : official journal of the Association for the Care of Asthma 20111101 |
| Investigation of the antiallergic activity of olopatadine on rhinitis induced by intranasal instillation of antigen in sensitized rats using thermography. | Asia Pacific allergy 20111001 |
| Levocetrizine has anti-inflammatory effects against Toll-like receptor (TLR)3 through the inhibition of Toll-IL-1 receptor (TIR)-domain-containing adapter inducing IFN-beta (TRIF) and receptor-interacting protein (RIP). | Auris, nasus, larynx 20110801 |
| Pharmacokinetic evaluation of levocetirizine. | Expert opinion on drug metabolism & toxicology 20110801 |
| Downmodulatory effects of cetirizine and levocetirizine on cytokine/chemokine production and CD54 expression in keratinocytes. | The Journal of dermatology 20110701 |
| The discovery of phthalazinone-based human H1 and H3 single-ligand antagonists suitable for intranasal administration for the treatment of allergic rhinitis. | Journal of medicinal chemistry 20110414 |
| Therapeutic effects of fermented red ginseng in allergic rhinitis: a randomized, double-blind, placebo-controlled study. | Allergy, asthma & immunology research 20110401 |
| Bilastine for the relief of allergy symptoms. | Drugs of today (Barcelona, Spain : 1998) 20110401 |
| Photodermatitis caused by oral ketoprofen: two case reports. | Contact dermatitis 20110301 |
| Chronic idiopathic urticaria in Taiwan: a clinical study of demographics, aggravating factors, laboratory findings, serum autoreactivity and treatment response. | Journal of the Formosan Medical Association = Taiwan yi zhi 20110301 |
| Anti-inflammatory activity and clinical efficacy of a 3-month levocetirizine therapy in mite-allergic children. | Inflammation & allergy drug targets 20110201 |
| Improving SAR symptoms with levocetirizine: evaluating active and placebo effects in pollen challenge vs. natural exposure studies. | Current medical research and opinion 20110101 |
| A case of chlorpheniramine maleate-induced hypersensitivity with aspirin intolerance. | Allergy, asthma & immunology research 20110101 |
| Evidence for clinical safety, efficacy, and parent and physician perceptions of levocetirizine for the treatment of children with allergic disease. | International archives of allergy and immunology 20110101 |
| Assessment of efficacy and impact on work productivity and attendance after a mandatory switch to generic second-generation antihistamines: results of a patient survey in Norway. | Clinical and molecular allergy : CMA 20110101 |
| The basophil activation test as a promising diagnostic tool in hypersensitivity to chironomid larvae. | Journal of investigational allergology & clinical immunology 20110101 |
| Levocetirizine induced hepatotoxicity in a patient with chronic urticaria. | Annals of hepatology 20110101 |
| Create a translational medicine knowledge repository--research downsizing, mergers and increased outsourcing have reduced the depth of in-house translational medicine expertise and institutional memory at many pharmaceutical and biotech companies: how will they avoid relearning old lessons? | Journal of translational medicine 20110101 |
| Standard operation procedures for conducting the on-the-road driving test, and measurement of the standard deviation of lateral position (SDLP). | International journal of general medicine 20110101 |
| Use of montelukast alone or in combination with desloratadine or levocetirizine in patients with persistent allergic rhinitis. | American journal of rhinology & allergy 20110101 |
| Allergic contact dermatitis due to carteolol, with good tolerance to betaxolol. | Dermatitis : contact, atopic, occupational, drug 20110101 |
| H1-antihistamine up-dosing in chronic spontaneous urticaria: patients' perspective of effectiveness and side effects--a retrospective survey study. | PloS one 20110101 |
| Consensus statement on the management of urticaria. | Indian journal of dermatology 20110101 |
| Ebastine in chronic spontaneous urticaria in higher doses. | Indian journal of dermatology 20110101 |
| Effect of bilastine upon nasal obstruction. | Journal of investigational allergology & clinical immunology 20110101 |
| Bilastine and quality of life. | Journal of investigational allergology & clinical immunology 20110101 |
| Nasal nitric oxide and nasal eosinophils decrease with levocetirizine in subjects with perennial allergic rhinitis. | American journal of rhinology & allergy 20110101 |
| Levocetirizine inhibits rhinovirus-induced up-regulation of fibrogenic and angiogenic factors in nasal polyp fibroblasts. | American journal of rhinology & allergy 20110101 |
| [The approaches to diagnostics and therapy of allergic rhinitis]. | Vestnik otorinolaringologii 20110101 |
| Allergic diseases in the elderly. | Clinical and translational allergy 20110101 |
| Diagnostic tools in Rhinology EAACI position paper. | Clinical and translational allergy 20110101 |
| [Off-season manifestations of pollen hypersensitization]. | Vestnik otorinolaringologii 20110101 |
| A Sensitive RP-HPLC Method for Simultaneous Estimation of Diethylcarbamazine and Levocetirizine in Tablet Formulation. | Indian journal of pharmaceutical sciences 20110101 |
| Enantioselective determination of cetirizine in human plasma by normal-phase liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20101215 |
| QTc interval prolongation by fexofenadine in healthy human volunteers and its correlation with plasma levels of fexofenadine: A demonstration of anticlockwise hysteresis. | Indian journal of pharmacology 20101201 |
| Levocetirizinium dipicrate. | Acta crystallographica. Section E, Structure reports online 20101201 |
| Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method. | Healthcare informatics research 20101201 |
| A randomized, double-blind, active-controlled, parallel-group pilot study to compare the efficacy and sedative effects of desloratadine 5 mg with levocetirizine 5 mg in the treatment of chronic idiopathic urticaria. | Journal of the American Academy of Dermatology 20101101 |
| Dose finding of melatonin for chronic idiopathic childhood sleep onset insomnia: an RCT. | Psychopharmacology 20101001 |
| An open-label, multicentre study of levocetirizine for the treatment of allergic rhinitis and urticaria in Taiwanese patients. | The Chinese journal of physiology 20100831 |
| Rupatadine and levocetirizine for seasonal allergic rhinitis: a comparative study of efficacy and safety. | Archives of otolaryngology--head & neck surgery 20100801 |
| Stereoselective and multiple carrier-mediated transport of cetirizine across Caco-2 cell monolayers with potential drug interaction. | Chirality 20100701 |
| Study of levocetirizine in seasonal allergic rhinitis. | Current medical research and opinion 20100601 |
| Long term treatment with montelukast and levocetirizine combination in persistent allergic rhinitis: review of recent evidence. | Journal of the Indian Medical Association 20100601 |
| Histamine induces Th2 activation through the histamine receptor 1 in house dust mite rhinitic but not asthmatic patients. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20100501 |
| Second-generation antihistamines for the treatment of chronic idiopathic urticaria. | Journal of drugs in dermatology : JDD 20100501 |
| Comparison of the efficacy and safety of bilastine 20 mg vs levocetirizine 5 mg for the treatment of chronic idiopathic urticaria: a multi-centre, double-blind, randomized, placebo-controlled study. | Allergy 20100401 |
| The effectiveness of levocetirizine and desloratadine in up to 4 times conventional doses in difficult-to-treat urticaria. | The Journal of allergy and clinical immunology 20100301 |
| Efficacy and safety of levocetirizine in improving symptoms and health-related quality of life in US adults with seasonal allergic rhinitis: a randomized, placebo-controlled study. | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20100301 |
| Effect of oral antihistamine on local injection site reactions with self-administered glatiramer acetate. | The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses 20100201 |
| Clinical assessment of levocetirizine and budesonide in treatment of persistent allergic rhinitis regarding to symptom severity. | Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20100201 |
| Cetirizine and loratadine: minimal risk of QT prolongation. | Prescrire international 20100201 |
| Loratadine versus levocetirizine in chronic idiopathic urticaria: A comparative study of efficacy and safety. | Indian journal of pharmacology 20100201 |
| Development of taste masked fast disintegrating films of levocetirizine dihydrochloride for oral use. | Current drug delivery 20100101 |
| Evaluation of treatment satisfaction in children with allergic disease treated with an antihistamine: an international, non-interventional, retrospective study. | Clinical drug investigation 20100101 |
| Levocetirizine-induced iridocyclitis in a patient with allergic rhinitis. | Journal of investigational allergology & clinical immunology 20100101 |
| Treatment of congestion in upper respiratory diseases. | International journal of general medicine 20100101 |
| Simultaneous determination of gliquidone, fexofenadine, buclizine, and levocetirizine in dosage formulation and human serum by RP-HPLC. | Journal of chromatographic science 20100101 |
| Safety and tolerability of levocetirizine dihydrochloride in infants and children with allergic rhinitis or chronic urticaria. | Allergy and asthma proceedings 20100101 |
| The employment of leukotriene antagonists in cutaneous diseases belonging to allergological field. | Mediators of inflammation 20100101 |
| Formulation and characterization of patient-friendly dosage form of ondansetron hydrochloride. | Journal of young pharmacists : JYP 20100101 |
| [Levocetirizine in therapy for allergic rhinitis]. | Vestnik otorinolaringologii 20100101 |
| Clinical utility and patient adherence with ebastine for allergic rhinitis. | Patient preference and adherence 20100101 |
| Severe chronic urticaria treated with oral mini-pulse steroid therapy. | Indian journal of dermatology 20100101 |
| Update on the management of chronic eczema: new approaches and emerging treatment options. | Clinical, cosmetic and investigational dermatology 20100101 |
| Study on the interaction of levocetirizine dihydrochloride with human serum albumin by molecular spectroscopy. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20091201 |
| Levocetirizine in the treatment of allergic diseases. | Expert opinion on pharmacotherapy 20091001 |
| Stereoselective renal tubular secretion of cetirizine enantiomers--initial plasma and urine data analysis may hold the key. | Fundamental & clinical pharmacology 20091001 |
| Sleep actigraphy evidence of improved sleep after treatment of allergic rhinitis. | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20091001 |
| The comparison of cetirizine, levocetirizine and placebo for the treatment of childhood perennial allergic rhinitis. | Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20090801 |
| Levocetirizine for the treatment of allergic rhinitis and chronic idiopathic urticaria in adults and children. | Clinical therapeutics 20090801 |
| FDC of montelukast with levocetirizine: focus on bilayer technology. | Journal of the Indian Medical Association 20090801 |
| [Antipruritic efficacy of a high-dosage antihistamine therapy. Results of a retrospectively analysed case series]. | Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20090701 |
| Enantiomeric purity control of levocetirizine in pharmaceuticals using anionic cyclodextrin mediated capillary electrophoresis separation and fiber-based diode array detection. | Die Pharmazie 20090701 |
| A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis. | Clinical therapeutics 20090501 |
| Comparison of the efficacy of levocetirizine 5 mg and desloratadine 5 mg in chronic idiopathic urticaria patients. | Allergy 20090401 |
| Levocetirizine inhibits rhinovirus-induced ICAM-1 and cytokine expression and viral replication in airway epithelial cells. | Antiviral research 20090301 |
| Effect of levocetirizine on nasal provocation testing with adenosine monophosphate compared with allergen challenge in allergic rhinitis. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20090301 |
| Update on prescription and over-the-counter histamine inverse agonists in rhinitis therapy. | Current allergy and asthma reports 20090301 |
| Levocetirizine for chronic idiopathic urticaria: a review. | Journal of drugs in dermatology : JDD 20090301 |
| Levocetirizine: from scientific evidence to a potent modern-day treatment of today's allergic patients. | Drugs of today (Barcelona, Spain : 1998) 20090301 |
| Psychoactive medication and traffic safety. | International journal of environmental research and public health 20090301 |
| Pharmacotherapy of allergic rhinitis: a pharmaco-economic approach. | Allergy 20090101 |
| The concept of receptor occupancy to predict clinical efficacy: a comparison of second generation H1 antihistamines. | Allergy and asthma proceedings 20090101 |
| Histamine H(3) receptor-mediated signaling protects mice from cerebral malaria. | PloS one 20090101 |
| Evaluation by (99m)Tc-pertechnetate scintigraphy of the effect of levocetirizine on salivary glands function, in allergic rhinitis patients. | Hellenic journal of nuclear medicine 20090101 |
| Treatment of chronic idiopathic urticaria with levamisole: a multicentre, randomized, double-blind, controlled trial. | The Journal of international medical research 20090101 |
| Local cytokines and clinical symptoms in children with allergic rhinitis after different treatments. | Biologics : targets & therapy 20090101 |
| Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast. | Drugs 20090101 |
| The anti-inflammatory effects of levocetirizine--are they clinically relevant or just an interesting additional effect? | Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20090101 |
| Chronic urticaria and treatment options. | Indian journal of dermatology 20090101 |
| Management of difficult urticaria. | Indian journal of dermatology 20090101 |
| Formulation and evaluation of taste-masked levocetirizine dihydrochloride orally disintegrating tablets. | PDA journal of pharmaceutical science and technology 20090101 |
| Once daily levocetirizine for the treatment of allergic rhinitis and chronic idiopathic urticaria. | Journal of asthma and allergy 20090101 |
| Ebastine in the light of CONGA recommendations for the development of third-generation antihistamines. | Journal of asthma and allergy 20090101 |
| Oral bioavailability and pharmacokinetic study of cetrizine HCl in Iranian healthy volunteers. | Research in pharmaceutical sciences 20090101 |
| Clinical and immunologic effects of H1 antihistamine preventive medication during honeybee venom immunotherapy. | The Journal of allergy and clinical immunology 20081101 |
| Levocetirizine in persistent allergic rhinitis: continuous or on-demand use? A pilot study. | Current medical research and opinion 20081001 |
| Levocetirizine modulates lymphocyte activation in patients with allergic rhinitis. | Journal of pharmacological sciences 20081001 |
| Effectiveness of twice daily azelastine nasal spray in patients with seasonal allergic rhinitis. | Therapeutics and clinical risk management 20081001 |
| Miscellaneous. | Indian journal of pharmacology 20081001 |
| Clinical pharmacology. | Indian journal of pharmacology 20081001 |
| Efficacy comparison of levocetirizine vs montelukast in ragweed sensitized patients. | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20080901 |
| Antihistamine effects on experimental middle ear inflammatory model. | European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20080801 |
| Non-sedating antihistamines in the treatment of chronic idiopathic urticaria using patient-reported outcomes. | Current medical research and opinion 20080801 |
| Allergic rhinitis in family practice: the role of levocetirizine in clinical care. | Postgraduate medicine 20080701 |
| Pharmacoeconomics of levocetirizine in allergic rhinitis and chronic idiopathic urticaria: considerations for the USA. | Expert review of pharmacoeconomics & outcomes research 20080601 |
| [Effect of modified wuhua decoction on skin barrier function in facial corticosteroid addictive dermatitis patients]. | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20080501 |
| A review of the role of levocetirizine as an effective therapy for allergic disease. | Expert opinion on pharmacotherapy 20080401 |
| [Effect of integrative Chinese and Western medicine in treating chronic urticaria and its impact on interleukin-10 and interleukin-8 in peripheral blood]. | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20080401 |
| Enantioseparation of cetirizine by sulfated-beta-cyclodextrin-mediated capillary electrophoresis. | Journal of separation science 20080301 |
| Inhibition of allergen-induced wheal and flare reactions by levocetirizine and desloratadine. | British journal of clinical pharmacology 20080201 |
| Stereoselective renal tubular secretion of levocetirizine and dextrocetirizine, the two enantiomers of the H1-antihistamine cetirizine. | Fundamental & clinical pharmacology 20080201 |
| Determination of levocetirizine in human plasma by liquid chromatography-electrospray tandem mass spectrometry: application to a bioequivalence study. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080201 |
| Anaphylaxis induced by Anisakis. | Allergologia et immunopathologia 20080101 |
| Xyzal (levocetirizine dihydrochloride). | Skinmed 20080101 |
| Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine : a comparative review. | Clinical pharmacokinetics 20080101 |
| Non-interventional study comparing treatment satisfaction in patients treated with antihistamines. | Clinical drug investigation 20080101 |
| OTC product: Zyrtec and Zyrtec-D 12 hour. | Journal of the American Pharmacists Association : JAPhA 20080101 |
| Efficacy of levocetirizine compared with montelukast in subjects with ragweed-induced seasonal allergic rhinitis in the Environmental Exposure Unit. | Allergy and asthma proceedings 20080101 |
| Treatment of chronic urticaria with narrowband ultraviolet B phototherapy: a randomized controlled trial. | Acta dermato-venereologica 20080101 |
| Physicochemical, pharmacological and pharmacokinetic properties of the zwitterionic antihistamines cetirizine and levocetirizine. | Current medicinal chemistry 20080101 |
| [Hypocalcaemia in a patient presenting severe solar urticaria]. | Annales de dermatologie et de venereologie 20080101 |
| Comparative efficacy of levocetirizine, desloratidine and fexofenadine by histamine wheal suppression test. | Indian journal of dermatology, venereology and leprology 20080101 |
| Influence of cetirizine and levocetirizine on two cytokines secretion in human airway epithelial cells. | Allergy and asthma proceedings 20080101 |
| Randomized double-blind placebo-controlled trial of sublingual immunotherapy in children with house dust mite allergy in primary care: study design and recruitment. | BMC family practice 20080101 |
| Quality of life in patients with persistent allergic rhinitis treated with montelukast alone or in combination with levocetirizine or desloratadine. | Journal of investigational allergology & clinical immunology 20080101 |
| Histamine 2 blocker potentiates the effects of histamine 1 blocker in suppressing histamine-induced wheal. | Indian journal of dermatology, venereology and leprology 20080101 |
| Simultaneous UV Spectrophotometric Estimation of Ambroxol Hydrochloride and Levocetirizine Dihydrochloride. | Indian journal of pharmaceutical sciences 20080101 |
| Levocetirizine (Xyzal) for allergic rhinitis and urticaria. | The Medical letter on drugs and therapeutics 20071203 |
| Levocetirizine does not prolong the QT/QTc interval in healthy subjects: results from a thorough QT study. | European journal of clinical pharmacology 20071101 |
| Safety of levocetirizine treatment in young atopic children: An 18-month study. | Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20070901 |
| H1-antihistamine treatment in young atopic children: effect on urticaria. | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20070901 |
| Peripheral and central H1 histamine receptor occupancy by levocetirizine, a non-sedating antihistamine; a time course study in the guinea pig. | British journal of pharmacology 20070801 |
| A case of urticaria induced by both hydroxyzine and cetirizine but not by levocetirizine. | Allergy 20070701 |
| New hay fever, hives treatment approved. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20070701 |
| Fixed drug eruption to cetirizine with positive lesional patch tests to the three piperazine derivatives. | International journal of dermatology 20070701 |
| Relevance of H1-receptor occupancy to H1-antihistamine dosing in children. | The Journal of allergy and clinical immunology 20070601 |
| Differentiation of monocytes into macrophages induces the upregulation of histamine H1 receptor. | The Journal of allergy and clinical immunology 20070201 |
| Evaluation of the effect of levocetirizine on nasal mucociliary clearance in allergic rhinitis patients by rhinoscintigraphy. | Nuclear medicine communications 20070201 |
| Impaired cognition and attention in adults: pharmacological management strategies. | Neuropsychiatric disease and treatment 20070201 |
| Contractile properties of various histaprodifen derivatives in guinea pig isolated ileum and trachea. | Pharmacology 20070101 |
| Comparative efficacy of cetirizine and levocetirizine in chronic idiopathic urticaria. | The Journal of dermatological treatment 20070101 |
| Levocetirizine and cytokine production and apoptosis of human eosinophils. | Allergy and asthma proceedings 20070101 |
| Levocetirizine: The latest treatment option for allergic rhinitis and chronic idiopathic urticaria. | Allergy and asthma proceedings 20070101 |
| [Antihistamines in allergic rhinitis]. | Otolaryngologia polska = The Polish otolaryngology 20070101 |
| [Visual evoked potentials in the in evaluation of the safety profile of levocetirizine]. | Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20070101 |
| [Does new antihistamines characterize tachyphylaxis phenomenon?]. | Otolaryngologia polska = The Polish otolaryngology 20070101 |
| Cellular adhesion molecules in chronic urticaria: modulation of serum levels occurs during levocetirizine treatment. | The British journal of dermatology 20061201 |
| Long QT syndrome in a patient with allergic rhinoconjunctivitis and auto-immune diabetes: focus on the choice of anti-H1 drugs. | European annals of allergy and clinical immunology 20061201 |
| New antihistamines: a critical view. | Jornal de pediatria 20061101 |
| Montelukast with desloratadine or levocetirizine for the treatment of persistent allergic rhinitis. | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20061101 |
| [Inhibition of histamine-induced wheel after a recommended single dose administration of 10 mg cetirizine, 5 mg desloratadine, 120 i 180 mg fexofenadine, 5 mg levocetirizine and 10 mg loratadine--a randomized, double-blind, placebo controlled trial]. | Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20061101 |
| [The effect of 5-days of cetirizine, desloratadine, fexofenadine 120 and 180 mg, levocetirizine, loratadine treatment on the histamine-induced skin reaction and skin blood flow--a randomized, double-blind, placebo controlled trial]. | Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20061101 |
| Levocetirizine improves health-related quality of life and health status in persistent allergic rhinitis. | Respiratory medicine 20061001 |
| Development of safer molecules through chirality. | Indian journal of medical sciences 20061001 |
| Stereoselective pharmacokinetics of cetirizine in the guinea pig: role of protein binding. | Biopharmaceutics & drug disposition 20060901 |
| Lichenoid eruption associated with the use of nebivolol. | The Annals of pharmacotherapy 20060901 |
| Levocetirizine in persistent allergic rhinitis and asthma: effects on symptoms, quality of life and inflammatory parameters. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20060901 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20060901 |
| Facial thermography is a sensitive tool to determine antihistaminic activity: comparison of levocetirizine and fexofenadine. | British journal of clinical pharmacology 20060801 |
| Pathophysiology of nasal obstruction and meta-analysis of early and late effects of levocetirizine. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20060801 |
| Chiral separation of cetirizine by capillary electrophoresis. | Electrophoresis 20060601 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20060601 |
| A comparison of levocetirizine and desloratadine in the histamine-induced wheal and flare response in human skin in vivo. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20060601 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Effects of levocetirizine as add-on therapy to fluticasone in seasonal allergic rhinitis. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20060501 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20060501 |
| Levocetirizine in patients with chronic idiopathic urticaria: results of a multicenter clinical practice study. | International journal of clinical pharmacology and therapeutics 20060401 |
| Levocetirizine is an effective treatment in patients suffering from chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled, parallel, multicenter study. | International journal of dermatology 20060401 |
| Levocetirizine in the treatment of chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled study. | The British journal of dermatology 20060301 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20060301 |
| Changes in pH differently affect the binding properties of histamine H1 receptor antagonists. | European journal of pharmacology 20060120 |
| Familial aquagenic urticaria and bernard-soulier syndrome. | Dermatology (Basel, Switzerland) 20060101 |
| A review of the evidence from comparative studies of levocetirizine and desloratadine for the symptoms of allergic rhinitis. | Clinical therapeutics 20060101 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20060101 |
| Levocetirizine: a review of its use in the management of allergic rhinitis and skin allergies. | Drugs 20060101 |
| Levocetirizine for treatment of immediate and delayed mosquito bite reactions. | Acta dermato-venereologica 20060101 |
| Levocetirizine as treatment for symptoms of seasonal allergic rhinitis. | B-ENT 20060101 |
| Effect of levocetirizine on the contraction induced by histamine on isolated rabbit bronchioles from precision-cut lung slices. | Pharmacology 20060101 |
| Comparison of the risk of drowsiness and sedation between levocetirizine and desloratadine: a prescription-event monitoring study in England. | Drug safety 20060101 |
| Levocetirizine: an update. | Current medicinal chemistry 20060101 |
| The histamine-induced enhanced expression of vascular cell adhesion molecule-1 by nasal polyp-derived fibroblasts is inhibited by levocetirizine. | American journal of rhinology 20060101 |
| Clinicopathologic features of systemic contact dermatitis from ethylenediamine in cetirizine and levocetirizine. | Dermatology (Basel, Switzerland) 20060101 |
| Cost effectiveness of levocetirizine in chronic idiopathic urticaria : a pooled analysis of two randomised controlled trials. | Clinical drug investigation 20060101 |
| Selecting the optimal oral antihistamine for patients with allergic rhinitis. | Drugs 20060101 |
| Desloratadine and levocetirizine improve nasal symptoms, airflow, and allergic inflammation in patients with perennial allergic rhinitis: a pilot study. | International immunopharmacology 20051201 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20051201 |
| Editorial foreword. | Therapeutics and clinical risk management 20051201 |
| Management of persistent allergic rhinitis: evidence-based treatment with levocetirizine. | Therapeutics and clinical risk management 20051201 |
| Levocetirizine: a modern H1-antihistamine for the treatment of allergic rhinitis. | Expert review of clinical immunology 20051101 |
| Fixed drug eruption: a novel side-effect of levocetirizine. | International journal of dermatology 20050901 |
| Histamine H1 receptor occupancy and pharmacodynamics of second generation H1-antihistamines. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20050901 |
| Levocetirizine: pharmacokinetics and pharmacodynamics in children age 6 to 11 years. | The Journal of allergy and clinical immunology 20050801 |
| A new antihistamine levocetirizine inhibits eosinophil adhesion to vascular cell adhesion molecule-1 under flow conditions. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20050801 |
| Efficacy and safety of levocetirizine on symptoms and health-related quality of life of children with perennial allergic rhinitis: a double-blind, placebo-controlled randomized clinical trial. | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20050801 |
| Levocetirizine has a longer duration of action on improving total nasal symptoms score than fexofenadine after single administration. | British journal of clinical pharmacology 20050701 |
| A treatment for allergic rhinitis: a view on the role of levocetirizine. | Current medical research and opinion 20050701 |
| A review of the evidence from comparative studies of levocetirizine and desloratadine for the symptoms of allergic rhinitis. | Clinical therapeutics 20050701 |
| Costs associated with persistent allergic rhinitis are reduced by levocetirizine. | Allergy 20050601 |
| Potential of levocetirizine in the relief of nasal congestion. | International journal of clinical practice 20050601 |
| Prediction of genotoxicity of chemical compounds by statistical learning methods. | Chemical research in toxicology 20050601 |
| Bacillus clausii effects in children with allergic rhinitis. | Allergy 20050501 |
| Levocetirizine in children: evidenced efficacy and safety in a 6-week randomized seasonal allergic rhinitis trial. | Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20050501 |
| Levocetirizine in 1-2 year old children: pharmacokinetic and pharmacodynamic profile. | International journal of clinical pharmacology and therapeutics 20050401 |
| Population pharmacokinetics of levocetirizine in very young children: the pediatricians' perspective. | Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20050301 |
| Retrospective population pharmacokinetics of levocetirizine in atopic children receiving cetirizine: the ETAC study. | British journal of clinical pharmacology 20050101 |
| Levocetirizine improves nasal symptoms and airflow in patients with persistent allergic rhinitis: a pilot study. | European annals of allergy and clinical immunology 20050101 |
| Pharmacological management of allergic rhinitis in the elderly: safety issues with oral antihistamines. | Drugs & aging 20050101 |
| Quantitative determination of cetirizine enantiomers in guinea pig plasma, brain tissue and microdialysis samples using liquid chromatography/tandem mass spectrometry. | Rapid communications in mass spectrometry : RCM 20050101 |
| Fixed drug eruption due to levocetirizine. | Indian journal of dermatology, venereology and leprology 20050101 |
| [Patient report: allergic rhinitis]. | Krankenpflege Journal 20050101 |
| Patients' perception of the value of levocetirizine in allergic diseases : a multicentre observational study in Germany. | Clinical drug investigation 20050101 |
| H1 histamine receptor mediates inflammatory responses in human keratinocytes. | The Journal of allergy and clinical immunology 20041101 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20041101 |
| Comparison of the effects in the nose and skin of a single dose of desloratadine and levocetirizine over 24 hours. | International archives of allergy and immunology 20041001 |
| Levocetirizine improves quality of life and reduces costs in long-term management of persistent allergic rhinitis. | The Journal of allergy and clinical immunology 20041001 |
| Modern histamine H1-receptor antagonists in the unified airway. | The Journal of allergy and clinical immunology 20040901 |
| Antihistamines: do they work? Further well-controlled trials involving larger samples are needed. | Allergy 20040801 |
| Interactions between eotaxin, histamine and mast cells in early microvascular events associated with eosinophil recruitment to the site of allergic skin reactions in humans. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040801 |
| Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans. | Fundamental & clinical pharmacology 20040801 |
| Large-scale overproduction, functional purification and ligand affinities of the His-tagged human histamine H1 receptor. | European journal of biochemistry 20040701 |
| Single and short-term dosing effects of levocetirizine on adenosine monophosphate bronchoprovocation in atopic asthma. | British journal of clinical pharmacology 20040701 |
| Levocetirizine: the allergist's arsenal grows larger. | Expert opinion on pharmacotherapy 20040701 |
| Levocetirizine improves nasal obstruction and modulates cytokine pattern in patients with seasonal allergic rhinitis: a pilot study. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040601 |
| A direct comparison of the efficacy of antihistamines in SAR and PAR: randomised, placebo-controlled studies with levocetirizine and loratadine using an environmental exposure unit - the Vienna Challenge Chamber (VCC). | Current medical research and opinion 20040601 |
| Levocetirizine: a new selective H1 receptor antagonist for use in allergic disorders. | Drugs of today (Barcelona, Spain : 1998) 20040501 |
| Comparative effects of desloratadine, fexofenadine, and levocetirizine on nasal adenosine monophosphate challenge in patients with perennial allergic rhinitis. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040401 |
| Levocetirizine better protects than desloratadine in a nasal provocation with allergen. | The Journal of allergy and clinical immunology 20040401 |
| Antihistamines and driving ability: evidence from on-the-road driving studies during normal traffic. | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20040301 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20040301 |
| Comparative clinical efficacy, onset and duration of action of levocetirizine and desloratadine for symptoms of seasonal allergic rhinitis in subjects evaluated in the Environmental Exposure Unit (EEU). | International journal of clinical practice 20040201 |
| Recovery of nitric oxide from acetylcholine-mediated vasodilatation in human skin in vivo. | Microcirculation (New York, N.Y. : 1994) 20040101 |
| Chronic urticaria: aetiology, management and current and future treatment options. | Drugs 20040101 |
| Chronic urticaria: clinical aspects and focus on a new antihistamine, levocetirizine. | Journal of drugs in dermatology : JDD 20040101 |
| Actual therapeutic management of allergic and hyperreactive nasal disorders. | GMS current topics in otorhinolaryngology, head and neck surgery 20040101 |
| Twenty-four-hour activity and consistency of activity of levocetirizine and desloratadine in the skin. | British journal of clinical pharmacology 20031001 |
| Compared pharmacological characteristics in humans of racemic cetirizine and levocetirizine, two histamine H1-receptor antagonists. | Biochemical pharmacology 20031001 |
| Comparison of the effects of desloratadine and levocetirizine on histamine-induced wheal, flare and itch in human skin. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20031001 |
| Levocetirizine: new preparation. Me-too: simply the active enantiomer of cetirizine. | Prescrire international 20031001 |
| Levocetirizine is effective for symptom relief including nasal congestion in adolescent and adult (PAR) sensitized to house dust mites. | Allergy 20030901 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20030901 |
| Driving ability after acute and sub-chronic administration of levocetirizine and diphenhydramine: a randomized, double-blind, placebo-controlled trial. | Psychopharmacology 20030801 |
| [Clinical aspects of anti-inflammatory action of antihistamines]. | Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20030601 |
| [Safety of new antihistamines]. | Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20030601 |
| Histamine H1 receptor antagonism by cetirizine in isolated guinea pig tissues: influence of receptor reserve and dissociation kinetics. | European journal of pharmacology 20030530 |
| [H1 histamine antagonists]. | Revue medicale de Bruxelles 20030401 |
| Acute and subchronic effects of levocetirizine and diphenhydramine on memory functioning, psychomotor performance, and mood. | The Journal of allergy and clinical immunology 20030301 |
| Comparative in vivo bioactivity of modern H1-antihistamines on AMP challenge in atopic asthma. | The Journal of allergy and clinical immunology 20030201 |
| Chronic urticaria: a role for newer immunomodulatory drugs? | American journal of clinical dermatology 20030101 |
| Assessing satisfaction with desloratadine and fexofenadine in allergy patients who report dissatisfaction with loratadine. | BMC family practice 20030101 |
| Acute allergy reaction after posterior sub-Tenon's triamcinolone injection in the treatment of intermediate uveitis in the asthmatic patient. | Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina 20030101 |
| Comparative pharmacology of H1 antihistamines: clinical relevance. | The American journal of medicine 20021216 |
| Blood distribution of levocetirizine, a new non-sedating histamine H1-receptor antagonist, in humans. | Fundamental & clinical pharmacology 20021201 |
| The new antihistamines--desloratadine and levocetirizine: a review. | Journal of drugs in dermatology : JDD 20021201 |
| Cetirizine and levocetirizine inhibit eotaxin-induced eosinophil transendothelial migration through human dermal or lung microvascular endothelial cells. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20020801 |
| Lack of effect of single and repeated doses of levocetirizine, a new antihistamine drug, on cognitive and psychomotor functions in healthy volunteers. | British journal of clinical pharmacology 20020701 |
| Gateways to Clinical Trials. June 2002. | Methods and findings in experimental and clinical pharmacology 20020601 |
| The Rx-to-OTC switch of Claritin, Allegra, and Zyrtec: an unprecedented FDA response to petitioners and the protection of public health. | The American University law review 20020601 |
| Major role for the carboxylic function of cetirizine and levocetirizine in their binding characteristics to human H1-histamine-receptors. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20020401 |
| [The first case of lasting pigmented toxidermia induced by cetirizine (Zyrtec, Virlix) and ticlopidine]. | Annales de dermatologie et de venereologie 20020401 |
| Binding characteristics of cetirizine and levocetirizine to human H(1) histamine receptors: contribution of Lys(191) and Thr(194). | Molecular pharmacology 20020201 |
| Antihistamines in late-phase clinical development for allergic disease. | Expert opinion on investigational drugs 20020201 |
| A double-blind, randomized, single-dose, crossover comparison of levocetirizine with ebastine, fexofenadine, loratadine, mizolastine, and placebo: suppression of histamine-induced wheal-and-flare response during 24 hours in healthy male subjects. | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20020201 |
| 24-hour efficacy of once-daily desloratadine therapy in patients with seasonal allergic rhinitis [ISRCTN32042139]. | BMC family practice 20020101 |
| Comparison of the effects of levocetirizine and loratadine on histamine-induced wheal, flare, and itch in human skin. | Allergy 20011001 |
| Absorption, distribution, metabolism and excretion of [14C]levocetirizine, the R enantiomer of cetirizine, in healthy volunteers. | European journal of clinical pharmacology 20011001 |
| Absorption and disposition of levocetirizine, the eutomer of cetirizine, administered alone or as cetirizine to healthy volunteers. | Fundamental & clinical pharmacology 20010801 |
| Effect of cetirizine, levocetirizine, and dextrocetirizine on histamine-induced nasal response in healthy adult volunteers. | Allergy 20010401 |
| A randomized, double-blind, crossover comparison among cetirizine, levocetirizine, and ucb 28557 on histamine-induced cutaneous responses in healthy adult volunteers. | Allergy 20010101 |
| Efficacy and safety of levocetirizine in seasonal allergic rhinitis. | Acta oto-rhino-laryngologica Belgica 20010101 |
| The acute and sub-chronic effects of levocetirizine, cetirizine, loratadine, promethazine and placebo on cognitive function, psychomotor performance, and weal and flare. | Current medical research and opinion 20010101 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.