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129954-34-3 | L-Proline, L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-
CAS No: 129954-34-3 Catalog No: AG000TU2 MDL No:
Product Description
Catalog Number:
AG000TU2
Chemical Name:
L-Proline, L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-
CAS Number:
129954-34-3
Molecular Formula:
C33H57N11O9
Molecular Weight:
751.8740
IUPAC Name:
(2S)-1-[2-[[(2S)-1-[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carboxylic acid
InChI:
InChI=1S/C33H57N11O9/c1-19(45)26(35)29(49)41-20(8-2-3-13-34)30(50)44-17-6-11-23(44)28(48)40-21(9-4-14-38-33(36)37)31(51)43-16-5-10-22(43)27(47)39-18-25(46)42-15-7-12-24(42)32(52)53/h19-24,26,45H,2-18,34-35H2,1H3,(H,39,47)(H,40,48)(H,41,49)(H,52,53)(H4,36,37,38)/t19-,20+,21+,22+,23+,24+,26+/m1/s1
InChI Key:
JTDTXGMXNXBGBZ-YVHUGQOKSA-N
SMILES:
NCCCC[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)O)CCCNC(=N)N)NC(=O)[C@H]([C@H](O)C)N
UNII:
TS9JR8EP1G
Properties
Complexity:
1360
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
7
Defined Bond Stereocenter Count:
0
Exact Mass:
751.434g/mol
Formal Charge:
0
Heavy Atom Count:
53
Hydrogen Bond Acceptor Count:
12
Hydrogen Bond Donor Count:
9
Isotope Atom Count:
0
Molecular Weight:
751.887g/mol
Monoisotopic Mass:
751.434g/mol
Rotatable Bond Count:
19
Topological Polar Surface Area:
322A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-6.1
Literature
| Title | Journal |
|---|---|
| [The role of opioid system in peculiarities of anti-anxiety effect of peptide anxiolytic selank]. | Eksperimental'naia i klinicheskaia farmakologiia 20120101 |
| [Effect of selank on the main carboxypeptidases in the rat nervous tissue]. | Zhurnal evoliutsionnoi biokhimii i fiziologii 20120101 |
| [Peptidergic modulation of the hippocampus synaptic activity]. | Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20111101 |
| Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank. | Regulatory peptides 20111010 |
| [Changes in expression of the genes for chemokines, cytokines, and their receptors in response to selank and its fragments]. | Genetika 20110501 |
| [Experimental optimization of learning and memory processes by selank]. | Eksperimental'naia i klinicheskaia farmakologiia 20100801 |
| Transcriptomic response of rat hippocampus and spleen cells to single and chronic administration of the peptide selank. | Doklady. Biochemistry and biophysics 20100101 |
| Antiviral properties of structural fragments of the peptide Selank. | Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20100101 |
| [Comparison of the effects of selank and tuftsin on the metabolism of serotonin in the brain of rats pretreated with PCPA]. | Eksperimental'naia i klinicheskaia farmakologiia 20090101 |
| [Antiviral activity of immunomodulator Selank in experimental influenza infection]. | Voprosy virusologii 20090101 |
| [Experimental hemorrhagic stroke: the study of neuropeptides (MIF, selank) in the intraperitoneal injection]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20090101 |
| Use of Selank to correct measures of integrative brain activity and biogenic amine levels in adult rats resulting from antenatal hypoxia. | Neuroscience and behavioral physiology 20080201 |
| [Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101 |
| [Compensatory effect of selank on the mnestic functions disturbed by neurotoxic damage of the noradrenergic system of the rat brain]. | Eksperimental'naia i klinicheskaia farmakologiia 20080101 |
| [Immunomodulatory effects of selank in patients with anxiety-asthenic disorders]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101 |
| [Effects of heptapeptide selank on genetically-based and situation-provoked symptoms of depression in behavior in WAG/Rij and Wistar rats, and in BALB/c mice]. | Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20080101 |
| [A comparative analysis of distribution of glyprolines administered by various routes]. | Bioorganicheskaia khimiia 20080101 |
| [Compensatory and antiamnestic effects of heptapeptide Selank in monkeys]. | Zhurnal evoliutsionnoi biokhimii i fiziologii 20080101 |
| Intranasal administration of the peptide Selank regulates BDNF expression in the rat hippocampus in vivo. | Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20080101 |
| [Effects of heptapeptide selank on the content of monoamines and their metabolites in the brain of BALB/C and C57Bl/6 mice: a comparative study]. | Eksperimental'naia i klinicheskaia farmakologiia 20080101 |
| Effect of selank on cognitive processes after damage inflicted to the cerebral catecholamine system during early ontogeny. | Bulletin of experimental biology and medicine 20071101 |
| Selank and its metabolites maintain homeostasis in the gastric mucosa. | Bulletin of experimental biology and medicine 20070101 |
| [Selank-induced normalizing effects on the integrative brain activity and biogenic amine level disorders due to antenatal hypoxia]. | Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20061101 |
| Naloxone-blocked depriming effect of anxiolytic selank on apomorphine-induced behavioral manifestations of hyperfunction of dopamine system. | Bulletin of experimental biology and medicine 20061101 |
| [Comparison of anticoagulant effects of regulatory proline-containing oligopeptides. Specificity of glyprolines, semax, and selank and potential of their practical application]. | Izvestiia Akademii nauk. Seriia biologicheskaia 20060101 |
| [Evenly tritium-labeled peptides and their in vivo and in vitro biodegradation]. | Bioorganicheskaia khimiia 20060101 |
| Influence of long-term treatment with tuftsin analogue TP-7 on the anxiety-phobic states and body weight. | Pharmacological reports : PR 20060101 |
| Seasonal effects of Selank on the behavior of hibernating animals. | Bulletin of experimental biology and medicine 20051201 |
| [Effect of new synthetic anxiolytic selank on gastric wall blood flow and mesenteryc lymphatic vessels contractility in anesthetized rats]. | Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20050201 |
| [Effects of the new peptide anxiolytic drug selank on the cardiovascular system functioning and respiration in cats]. | Eksperimental'naia i klinicheskaia farmakologiia 20050101 |
| [Leu-enkephalin homogeneously labeled with tritium in studying the Selank inhibiting effect on the enkephalin-degrading enzymes of human plasma]. | Bioorganicheskaia khimiia 20040101 |
| A new property of the synthetic anxiolytic Selank and its derivatives. | Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20040101 |
| Selank and short peptides of the tuftsin family in the regulation of adaptive behavior in stress. | Neuroscience and behavioral physiology 20031101 |
| The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats. | Neuroscience and behavioral physiology 20030901 |
| [Highly stable regulatory oligopeptides: experience and applications]. | Patologicheskaia fiziologiia i eksperimental'naia terapiia 20030101 |
| [Selank and short peptides of Taftsin derivatives in regulation of adaptive behavior of animals in stress]. | Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20020601 |
| Effects of Selank on behavioral reactions and activities of plasma enkephalin-degrading enzymes in mice with different phenotypes of emotional and stress reactions. | Bulletin of experimental biology and medicine 20020201 |
| [Optimizing action of synthetic peptide Selank on active avoidance conditioning test in rats]. | Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20020101 |
| The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity. | Bulletin of experimental biology and medicine 20010401 |
| [Semax and selank inhibit the enkephalin-degrading enzymes from human serum]]. | Bioorganicheskaia khimiia 20010101 |
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