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Home > Quinoline > 129075-73-6
129075-73-6 | 1(2H)-Isoquinolinone, 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]-
CAS No: 129075-73-6 Catalog No: AG000YUE MDL No:MFCD02258932
Product Description
Catalog Number:
AG000YUE
Chemical Name:
1(2H)-Isoquinolinone, 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]-
CAS Number:
129075-73-6
Molecular Formula:
C18H26N2O2
Molecular Weight:
302.4112
MDL Number:
MFCD02258932
IUPAC Name:
5-(4-piperidin-1-ylbutoxy)-3,4-dihydro-2H-isoquinolin-1-one
InChI:
InChI=1S/C18H26N2O2/c21-18-16-7-6-8-17(15(16)9-10-19-18)22-14-5-4-13-20-11-2-1-3-12-20/h6-8H,1-5,9-14H2,(H,19,21)
InChI Key:
RVOUDNBEIXGHJY-UHFFFAOYSA-N
SMILES:
O=C1NCCc2c1cccc2OCCCCN1CCCCC1
UNII:
5007H57E2L
Properties
Complexity:
355
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
302.199g/mol
Formal Charge:
0
Heavy Atom Count:
22
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
302.418g/mol
Monoisotopic Mass:
302.199g/mol
Rotatable Bond Count:
6
Topological Polar Surface Area:
41.6A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.8
Literature
| Title | Journal |
|---|---|
| Expression and functional properties of TRPM2 channels in dopaminergic neurons of the substantia nigra of the rat. | Journal of neurophysiology 20111201 |
| Perinatal asphyxia: current status and approaches towards neuroprotective strategies, with focus on sentinel proteins. | Neurotoxicity research 20110501 |
| 5-Benzamidoisoquinolin-1-ones and 5-(ω-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2). | Journal of medicinal chemistry 20110414 |
| The KRAS promoter responds to Myc-associated zinc finger and poly(ADP-ribose) polymerase 1 proteins, which recognize a critical quadruplex-forming GA-element. | The Journal of biological chemistry 20100716 |
| Mechanical stretch enhances NF-kappaB-dependent gene expression and poly(ADP-ribose) synthesis in synovial cells. | Journal of biochemistry 20100501 |
| Inhibition of poly adenosine diphosphate-ribose polymerase decreases hepatocellular carcinoma growth by modulation of tumor-related gene expression. | Hepatology (Baltimore, Md.) 20100101 |
| Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors. | Bioorganic & medicinal chemistry 20091101 |
| Poly(ADP-ribose) polymerase-1 modulation of in vivo response of brain hypoxia-inducible factor-1 to hypoxia/reoxygenation is mediated by nitric oxide and factor inhibiting HIF. | Journal of neurochemistry 20091001 |
| MLH1 mediates PARP-dependent cell death in response to the methylating agent N-methyl-N-nitrosourea. | British journal of cancer 20090804 |
| Calpain activation is not required for AIF translocation in PARP-1-dependent cell death (parthanatos). | Journal of neurochemistry 20090701 |
| Involvement of independent mechanism upon poly(ADP-ribose) polymerase (PARP) activation in methylmercury cytotoxicity in rat cerebellar granule cell culture. | Journal of neuroscience research 20081115 |
| Prolonged exposures of cerebellar granule neurons to S-nitroso-N-acetylpenicillamine (SNAP) induce neuronal damage independently of peroxynitrite. | Brain research 20080916 |
| Inhibition of the activity of poly (ADP-ribose) polymerase reduces heart ischaemia/reperfusion injury via suppressing JNK-mediated AIF translocation. | Journal of cellular and molecular medicine 20080801 |
| Adenosine receptor ligands protect against a combination of apoptotic and necrotic cell death in cerebellar granule neurons. | Experimental brain research 20080301 |
| Differences among cell types in NAD(+) compartmentalization: a comparison of neurons, astrocytes, and cardiac myocytes. | Journal of neuroscience research 20071115 |
| N-methyl-N'-nitro-N-nitrosoguanidine activates multiple cell death mechanisms in human fibroblasts. | DNA and cell biology 20070901 |
| Combination treatment with arsenic trioxide and phytosphingosine enhances apoptotic cell death in arsenic trioxide-resistant cancer cells. | Molecular cancer therapeutics 20070101 |
| Inhibition of poly(ADP-ribose) polymerase modulates tumor-related gene expression, including hypoxia-inducible factor-1 activation, during skin carcinogenesis. | Cancer research 20060601 |
| Identification of poly(ADP-ribose)polymerase-1 and Ku70/Ku80 as transcriptional regulators of S100A9 gene expression. | BMC molecular biology 20060101 |
| Phytosphingosine in combination with ionizing radiation enhances apoptotic cell death in radiation-resistant cancer cells through ROS-dependent and -independent AIF release. | Blood 20050215 |
| Poly(ADP-ribose) polymerase-1 promotes microglial activation, proliferation, and matrix metalloproteinase-9-mediated neuron death. | Journal of immunology (Baltimore, Md. : 1950) 20050215 |
| NAD+ as a metabolic link between DNA damage and cell death. | Journal of neuroscience research 20050101 |
| Group I metabotropic glutamate receptors stimulate the activity of poly(ADP-ribose) polymerase in mammalian mGlu1-transfected cells and in cortical cell cultures. | Neuropharmacology 20050101 |
| Caspase-independent cell death by arsenic trioxide in human cervical cancer cells: reactive oxygen species-mediated poly(ADP-ribose) polymerase-1 activation signals apoptosis-inducing factor release from mitochondria. | Cancer research 20041215 |
| Adenine nucleotide metabolism and cell fate after oxidant exposure of rat cortical neurons: effects of inhibition of poly(ADP-ribose) polymerase. | Brain research 20040702 |
| An enzymatic assay for poly(ADP-ribose) polymerase-1 (PARP-1) via the chemical quantitation of NAD(+): application to the high-throughput screening of small molecules as potential inhibitors. | Analytical biochemistry 20040301 |
| Effect of poly(ADP-ribose) polymerase inhibitors on oxidative stress evoked hydroxyl radical level and macromolecules oxidation in cell free system of rat brain cortex. | Neuroscience letters 20040206 |
| Differential role of poly(ADP-ribose) polymerase-1in apoptotic and necrotic neuronal death induced by mild or intense NMDA exposure in vitro. | Molecular and cellular neurosciences 20040101 |
| Hypoglycemic neuronal death and cognitive impairment are prevented by poly(ADP-ribose) polymerase inhibitors administered after hypoglycemia. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20031119 |
| Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia. | The Journal of pharmacology and experimental therapeutics 20030601 |
| Comet assay as a novel approach for studying DNA damage in focal cerebral ischemia: differential effects of NMDA receptor antagonists and poly(ADP-ribose) polymerase inhibitors. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20020601 |
| Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia. | Cell death and differentiation 20010901 |
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