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129-46-4 | Suramin HeXasodium Salt
CAS No: 129-46-4 Catalog No: AG003UH6 MDL No:MFCD00210217
Product Description
Catalog Number:
AG003UH6
Chemical Name:
Suramin HeXasodium Salt
CAS Number:
129-46-4
Molecular Formula:
C51H34N6Na6O23S6
Molecular Weight:
1429.1707
MDL Number:
MFCD00210217
IUPAC Name:
hexasodium;8-[[4-methyl-3-[[3-[[3-[[2-methyl-5-[(4,6,8-trisulfonatonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonate
InChI:
InChI=1S/C51H40N6O23S6.6Na/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80;;;;;;/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80);;;;;;/q;6*+1/p-6
InChI Key:
VAPNKLKDKUDFHK-UHFFFAOYSA-H
SMILES:
O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
EC Number:
204-949-3
UNII:
89521262IH
Properties
Complexity:
2940
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
7
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
1427.939g/mol
Formal Charge:
0
Heavy Atom Count:
92
Hydrogen Bond Acceptor Count:
23
Hydrogen Bond Donor Count:
6
Isotope Atom Count:
0
Molecular Weight:
1429.151g/mol
Monoisotopic Mass:
1427.939g/mol
Rotatable Bond Count:
10
Topological Polar Surface Area:
551A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Discovery of potent and selective sirtuin 2 (SIRT2) inhibitors using a fragment-based approach. | Journal of medicinal chemistry 20141023 |
| Purinergic signaling via P2Y receptors up-mediates IL-6 production by liver macrophages/Kupffer cells. | The Journal of toxicological sciences 20140601 |
| Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy. | Translational psychiatry 20140601 |
| The function of P2X3 receptor and NK1 receptor antagonists on cyclophosphamide-induced cystitis in rats. | World journal of urology 20140201 |
| Falcipain-2 inhibition by suramin and suramin analogues. | Bioorganic & medicinal chemistry 20130701 |
| Antipurinergic therapy corrects the autism-like features in the poly(IC) mouse model. | PloS one 20130101 |
| Interaction of medullary P2 and glutamate receptors mediates the vasodilation in the hindlimb of rat. | Purinergic signalling 20121201 |
| Suramin inhibits the growth of nasopharyngeal carcinoma cells via the downregulation of osteopontin. | Molecular medicine reports 20121201 |
| Characterization of ecto-ATPase activity in the surface of LLC-PK1 cells and its modulation by ischemic conditions. | Biochimica et biophysica acta 20121201 |
| A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase. | The Biochemical journal 20121115 |
| Suramin affects metalloproteinase-9 activity and increases β-dystroglycan levels in the diaphragm of the dystrophin-deficient mdx mouse. | Muscle & nerve 20121101 |
| Diabetes-induced renal injury in rats is attenuated by suramin. | The Journal of pharmacology and experimental therapeutics 20121001 |
| Reactive oxygen species contribute to the promotion of the ATP-mediated proliferation of mouse skeletal myoblasts. | Free radical biology & medicine 20121001 |
| Systemic blockade of nicotinic and purinergic receptors inhibits ventilation and increases apnoea frequency in newborn rats. | Experimental physiology 20120801 |
| Modulation of purinergic neuromuscular transmission by phorbol dibutyrate is independent of protein kinase C in murine urinary bladder. | The Journal of pharmacology and experimental therapeutics 20120801 |
| Safety and efficacy of the 10-day melarsoprol schedule for the treatment of second stage Rhodesiense sleeping sickness. | PLoS neglected tropical diseases 20120801 |
| Timing of the administration of suramin treatment after muscle injury. | Muscle & nerve 20120701 |
| Phase I/II trial of non-cytotoxic suramin in combination with weekly paclitaxel in metastatic breast cancer treated with prior taxanes. | Cancer chemotherapy and pharmacology 20120701 |
| Substrates for efficient fluorometric screening employing the NAD-dependent sirtuin 5 lysine deacylase (KDAC) enzyme. | Journal of medicinal chemistry 20120614 |
| Structure-based inhibition of Norovirus RNA-dependent RNA polymerases. | Journal of molecular biology 20120608 |
| Extracellular ATP induces fast and transient non-selective cationic currents and cytosolic Ca2+ changes in human umbilical artery smooth muscle cells. | Purinergic signalling 20120601 |
| Pannexin1-mediated ATP release provides signal transmission between Neuro2A cells. | Neurochemical research 20120601 |
| Lesson of the month: a psychiatric diagnosis overturned by a blood film. | Clinical medicine (London, England) 20120601 |
| An ATP signalling pathway in plant cells: extracellular ATP triggers programmed cell death in Populus euphratica. | Plant, cell & environment 20120501 |
| Perspective on the role of P2X-purinoceptor activation in human vas deferens contractility. | Experimental physiology 20120501 |
| Leishmania amazonensis impairs DC function by inhibiting CD40 expression via A2B adenosine receptor activation. | European journal of immunology 20120501 |
| Regulation of ventral surface CO2/H+-sensitive neurons by purinergic signalling. | The Journal of physiology 20120501 |
| Effect of development on [Ca2+]i transients to ATP in petrosal ganglion neurons: a pharmacological approach using optical recording. | Journal of applied physiology (Bethesda, Md. : 1985) 20120415 |
| Recovery from glycerol-induced acute kidney injury is accelerated by suramin. | The Journal of pharmacology and experimental therapeutics 20120401 |
| Prejunctional facilitatory effect of a thiol-alkylating agent N-Ethylmaleimide on neurogenic contractions in rat prostate smooth muscle. | Neurourology and urodynamics 20120401 |
| Adenosine trisphosphate appears to act via different receptors in terminals versus somata of the hypothalamic neurohypophysial system. | Journal of neuroendocrinology 20120401 |
| P2X purinergic receptor knockout mice reveal endogenous ATP modulation of both vasopressin and oxytocin release from the intact neurohypophysis. | Journal of neuroendocrinology 20120401 |
| Allosteric activation of human α-thrombin through exosite 2 by suramin analogs. | Archives of biochemistry and biophysics 20120401 |
| Synthesis and structure-activity relationships of new quinolone-type molecules against Trypanosoma brucei. | Journal of medicinal chemistry 20120322 |
| A returning traveller with fever, facial swelling, and skin lesions. | BMJ (Clinical research ed.) 20120322 |
| Trypanosoma brucei rhodesiense infection in a German traveller returning from the Masai Mara area, Kenya, January 2012. | Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20120308 |
| Human African trypanosomiasis in a Belgian traveller returning from the Masai Mara area, Kenya, February 2012. | Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20120308 |
| Age-related changes in afferent responses in sensory neurons to mechanical stimulation of osteoblasts in coculture system. | American journal of physiology. Cell physiology 20120301 |
| Characterization of suramin binding sites on the human group IIA secreted phospholipase A2 by site-directed mutagenesis and molecular dynamics simulation. | Archives of biochemistry and biophysics 20120301 |
| Synthesis and anti-HIV activities of suramin conjugates of 3'-fluoro- 2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine. | Medicinal chemistry (Shariqah (United Arab Emirates)) 20120301 |
| Progression-free and overall survival in patients with relapsed/refractory germ cell tumors treated with single-agent chemotherapy: endpoints for clinical trial design. | Cancer 20120215 |
| Biochemical characterization of an ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP, E.C. 3.1.4.1) from rat cardiac soluble and microsomal fractions. | Journal of enzyme inhibition and medicinal chemistry 20120201 |
| Multiorgan dysfunction caused by travel-associated African trypanosomiasis. | Emerging infectious diseases 20120201 |
| High-throughput decoding of antitrypanosomal drug efficacy and resistance. | Nature 20120125 |
| Blockade of P2 nucleotide receptors after spinal cord injury reduced the gliotic response and spared tissue. | Journal of molecular neuroscience : MN 20120101 |
| Molecular basis of selective antagonism of the P2X1 receptor for ATP by NF449 and suramin: contribution of basic amino acids in the cysteine-rich loop. | British journal of pharmacology 20120101 |
| Inhibition of ecto-ATPase activity by curcumin in hepatocellular carcinoma HepG2 cells. | The journal of physiological sciences : JPS 20120101 |
| Suramin ameliorates collagen induced arthritis. | International immunopharmacology 20120101 |
| Suramin alleviates glomerular injury and inflammation in the remnant kidney. | PloS one 20120101 |
| Covalent modification of mutant rat P2X2 receptors with a thiol-reactive fluorophore allows channel activation by zinc or acidic pH without ATP. | PloS one 20120101 |
| Propranolol modulates the collateral vascular responsiveness to vasopressin via a G(α)-mediated pathway in portal hypertensive rats. | Clinical science (London, England : 1979) 20111201 |
| Heparanase enhances nerve-growth-factor-induced PC12 cell neuritogenesis via the p38 MAPK pathway. | The Biochemical journal 20111201 |
| ATP: a mediator for HCl-induced TRPV1 activation in esophageal mucosa. | American journal of physiology. Gastrointestinal and liver physiology 20111201 |
| FRET detection of calmodulin binding to the cardiac RyR2 calcium release channel. | Biophysical journal 20111102 |
| Aldosterone stimulates vacuolar H(+)-ATPase activity in renal acid-secretory intercalated cells mainly via a protein kinase C-dependent pathway. | American journal of physiology. Cell physiology 20111101 |
| Purinergic regulation of high-glucose-induced caspase-1 activation in the rat retinal Müller cell line rMC-1. | American journal of physiology. Cell physiology 20111101 |
| Uridine adenosine tetraphosphate induces contraction of airway smooth muscle. | American journal of physiology. Lung cellular and molecular physiology 20111101 |
| In vitro antitrypanosomal activity of plant terpenes against Trypanosoma brucei. | Phytochemistry 20111101 |
| Chemotherapy for advanced adrenal cancer: improvement from a molecular approach? | BJU international 20111101 |
| Role for purinergic receptors in memory processing in young chicks. | Behavioural brain research 20111001 |
| Characterization of P2Y receptors mediating ATP induced relaxation in guinea pig airway smooth muscle: involvement of prostaglandins and K+ channels. | Pflugers Archiv : European journal of physiology 20111001 |
| The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site. | The Journal of biological chemistry 20110909 |
| Antagonists show GTP-sensitive high-affinity binding to the sigma-1 receptor. | British journal of pharmacology 20110901 |
| A comparison of methods for quantifying angiogenesis in the Matrigel assay in vitro. | Tissue engineering. Part C, Methods 20110901 |
| Delayed administration of suramin attenuates the progression of renal fibrosis in obstructive nephropathy. | The Journal of pharmacology and experimental therapeutics 20110901 |
| The P2Y(2) nucleotide receptor mediates tissue factor expression in human coronary artery endothelial cells. | The Journal of biological chemistry 20110729 |
| Opposite effects of P2X7 and P2Y2 nucleotide receptors on α-secretase-dependent APP processing in Neuro-2a cells. | FEBS letters 20110721 |
| Endogenous sphingosine 1-phosphate regulates spontaneous glutamate release from mossy fiber terminals via S1P(3) receptors. | Life sciences 20110718 |
| Potentiation of regulatory volume decrease by a p2-like receptor and arachidonic acid in american alligator erythrocytes. | The Journal of membrane biology 20110701 |
| Opposite effect of ATP on contraction force of tonic and phasic skeletal muscles in frogs. | Bulletin of experimental biology and medicine 20110701 |
| Study of the reversal effect of NF449 on neuromuscular blockade induced by d-tubocurarine. | Life sciences 20110606 |
| Sphingosine 1-phosphate (S1P)/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility. | Journal of hepatology 20110601 |
| Distraction osteogenesis-induced muscle fibrosis may not be associated with TGF-β1. | Journal of pediatric orthopedics 20110601 |
| Suramin inhibits renal fibrosis in chronic kidney disease. | Journal of the American Society of Nephrology : JASN 20110601 |
| P2X(7) receptor antagonists display agonist-like effects on cell signaling proteins. | Biochimica et biophysica acta 20110501 |
| Identification of P2X₃ and P2X₇ purinergic receptors activated by ATP in rat lacrimal gland. | Investigative ophthalmology & visual science 20110501 |
| Tissue protective and anti-fibrotic actions of suramin: new uses of an old drug. | Current clinical pharmacology 20110501 |
| Molecular determinants of potent P2X2 antagonism identified by functional analysis, mutagenesis, and homology docking. | Molecular pharmacology 20110401 |
| Anti-angiogenic activity of Gynura segetum leaf extracts and its fractions. | Journal of ethnopharmacology 20110324 |
| Suramab, a novel antiangiogenic agent, reduces tumor growth and corneal neovascularization. | Cancer chemotherapy and pharmacology 20110301 |
| Differentiation induction of mouse embryonic stem cells into sinus node-like cells by suramin. | International journal of cardiology 20110217 |
| Development of polymer-membrane based electrodes for suramin. | Analytica chimica acta 20110207 |
| Purinergic mechanisms of lateral parabrachial nucleus facilitate sodium depletion-induced NaCl intake. | Brain research 20110204 |
| In airways ATP refills sarcoplasmic reticulum via P2X smooth muscle receptors and induces contraction through P2Y epithelial receptors. | Pflugers Archiv : European journal of physiology 20110201 |
| Maintained tubuloglomerular feedback responses during acute inhibition of P2 purinergic receptors in mice. | American journal of physiology. Renal physiology 20110201 |
| Application of isothermal titration calorimetry and column chromatography for identification of biomolecular targets. | Nature protocols 20110201 |
| Purinergic modulation of glucose uptake into cultured rat podocytes: effect of diabetic milieu. | Biochemical and biophysical research communications 20110114 |
| Phosphoinositide 3-kinase-dependent antagonism in mammalian olfactory receptor neurons. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20110105 |
| Purinergic receptor agonists modulate phagocytosis and clearance of apoptotic cells in macrophages. | Immunobiology 20110101 |
| Propionate-induced epithelial K(+) and Cl(-)/HCO3(-) secretion and free fatty acid receptor 2 (FFA2, GPR43) expression in the guinea pig distal colon. | Pflugers Archiv : European journal of physiology 20110101 |
| Expression of acid-sensing ion channels in intestinal epithelial cells and their role in the regulation of duodenal mucosal bicarbonate secretion. | Acta physiologica (Oxford, England) 20110101 |
| Prevention of muscle fibrosis and myonecrosis in mdx mice by suramin, a TGF-β1 blocker. | Muscle & nerve 20110101 |
| Modulation of phosphofructokinase (PFK) from Setaria cervi, a bovine filarial parasite, by different effectors and its interaction with some antifilarials. | Parasites & vectors 20110101 |
| Bladder tissue pharmacokinetics of intravesical mitomycin C and suramin in dogs. | The AAPS journal 20101201 |
| Core/shell microspheres via coaxial electrohydrodynamic atomization for sequential and parallel release of drugs. | Journal of biomedical materials research. Part A 20101201 |
| Dexamethasone enhances ATP-induced inflammatory responses in endothelial cells. | The Journal of pharmacology and experimental therapeutics 20101201 |
| Astrocytes in the retrotrapezoid nucleus sense H+ by inhibition of a Kir4.1-Kir5.1-like current and may contribute to chemoreception by a purinergic mechanism. | Journal of neurophysiology 20101201 |
| Identification of specific inhibitors for a trypanosomatid RNA editing reaction. | RNA (New York, N.Y.) 20101201 |
| Dyes, trypanosomiasis and DNA: a historical and critical review. | Biotechnic & histochemistry : official publication of the Biological Stain Commission 20101201 |
| The NMR solution structure of human epidermal growth factor (hEGF) at physiological pH and its interactions with suramin. | Biochemical and biophysical research communications 20101126 |
| Phase I trial of non-cytotoxic suramin as a modulator of docetaxel and gemcitabine therapy in previously treated patients with non-small cell lung cancer. | Cancer chemotherapy and pharmacology 20101101 |
| Purine receptors modulate chondrocyte extracellular inorganic pyrophosphate production. | Osteoarthritis and cartilage 20101101 |
| Paclitaxel and suramin-loaded core/shell microspheres in the treatment of brain tumors. | Biomaterials 20101101 |
| Sympathetic vasoconstriction is potentiated in arteries caudal but not rostral to a spinal cord transection in rats. | Journal of neurotrauma 20101101 |
| Characterization of nestin expression in the spinal cord of GFP transgenic mice after peripheral nerve injury. | Neuroscience 20101027 |
| Differential effects of uridine adenosine tetraphosphate on purinoceptors in the rat isolated perfused kidney. | British journal of pharmacology 20101001 |
| Discovery and mechanistic study of a class of protein arginine methylation inhibitors. | Journal of medicinal chemistry 20100826 |
| Function and regulation of the mitochondrial sirtuin isoform Sirt5 in Mammalia. | Biochimica et biophysica acta 20100801 |
| Functional ligand-gated purinergic receptors (P2X) in rat vestibular ganglion neurons. | Hearing research 20100801 |
| Blocking P2X receptors can inhibit the injury-induced proliferation of olfactory epithelium progenitor cells in adult mouse. | International journal of pediatric otorhinolaryngology 20100701 |
| Assessment and characterization of purinergic contractions and relaxations in the rat urinary bladder. | Basic & clinical pharmacology & toxicology 20100701 |
| Visualization of Ins(1,4,5)P3 dynamics in living cells: two distinct pathways for Ins(1,4,5)P3 generation following mechanical stimulation of HSY-EA1 cells. | Journal of cell science 20100701 |
| Nickel sulfate induces location-dependent atrophy of mouse olfactory epithelium: protective and proliferative role of purinergic receptor activation. | Toxicological sciences : an official journal of the Society of Toxicology 20100601 |
| P2Y2 receptors mediate ATP-induced resensitization of TRPV1 expressed by kidney projecting sensory neurons. | American journal of physiology. Regulatory, integrative and comparative physiology 20100601 |
| Intracellular Ca2+ responses and cell volume regulation upon cholinergic and purinergic stimulation in an immortalized salivary cell line. | European journal of oral sciences 20100601 |
| Purinoreceptor-mediated current in myocytes from renal resistance arteries. | British journal of pharmacology 20100601 |
| In vitro activity and preliminary toxicity of various diamidine compounds against Trypanosoma evansi. | Veterinary parasitology 20100511 |
| Chemerin, a novel adipokine in the regulation of angiogenesis. | The Journal of clinical endocrinology and metabolism 20100501 |
| Evaluation of anti-allergic activity of gossypin and suramin in mast cell-mediated allergy model. | Indian journal of biochemistry & biophysics 20100401 |
| Modulation of cell surface architecture in gastrulating chick embryo in response to altered fibroblast growth factor (FGF) signaling. | Indian journal of experimental biology 20100401 |
| Shockwaves increase T-cell proliferation and IL-2 expression through ATP release, P2X7 receptors, and FAK activation. | American journal of physiology. Cell physiology 20100301 |
| Modulation of epithelial sodium channel activity by lipopolysaccharide in alveolar type II cells: involvement of purinergic signaling. | American journal of physiology. Lung cellular and molecular physiology 20100301 |
| The P2Y2 receptor sensitizes mouse bladder sensory neurons and facilitates purinergic currents. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100210 |
| Bidirectional calcium signaling between satellite glial cells and neurons in cultured mouse trigeminal ganglia. | Neuron glia biology 20100201 |
| Endothelial P2Y2 receptor regulates LPS-induced neutrophil transendothelial migration in vitro. | Molecular immunology 20100201 |
| Calcium entry is regulated by Zn2+ in relation to extracellular ionic environment in human airway epithelial cells. | Respiratory physiology & neurobiology 20100131 |
| Two suramin binding sites are present in guinea pig but only one in murine native P2X myenteric receptors. | European journal of pharmacology 20100125 |
| Human African trypanosomiasis. | Lancet (London, England) 20100109 |
| Killer coma: the evolving story of sleeping sickness treatment. | Lancet (London, England) 20100109 |
| Organic dyes as small molecule protein-protein interaction inhibitors for the CD40-CD154 costimulatory interaction. | Journal of molecular recognition : JMR 20100101 |
| The effect of subconjunctival suramin on corneal neovascularization in rabbits. | Cornea 20100101 |
| Extracellular ATP and P2Y2 receptors mediate intercellular Ca(2+) waves induced by mechanical stimulation in submandibular gland cells: Role of mitochondrial regulation of store operated Ca(2+) entry. | Cell calcium 20100101 |
| P2Y receptors and atherosclerosis in apolipoprotein E-deficient mice. | British journal of pharmacology 20100101 |
| Purinergic receptor functionality is necessary for infection of human hepatocytes by hepatitis delta virus and hepatitis B virus. | PloS one 20100101 |
| [The sleeping disease drug Germanine as an instrument for propaganda: reception in literature and film during National Socialism]. | Wurzburger medizinhistorische Mitteilungen 20100101 |
| ATP released by electrical stimuli elicits calcium transients and gene expression in skeletal muscle. | The Journal of biological chemistry 20091211 |
| Functional characterization of intracellular Dictyostelium discoideum P2X receptors. | The Journal of biological chemistry 20091211 |
| Melanin-concentrating hormone reduces somatolactin release from cultured goldfish pituitary cells. | The Journal of endocrinology 20091201 |
| Nicotinic acetylcholine receptors do not mediate excitatory transmission in young rat carotid body. | Journal of applied physiology (Bethesda, Md. : 1985) 20091201 |
| Spontaneous oscillations in intracellular Ca(2+) concentration via purinergic receptors elicit transient cell swelling in rat parotid ducts. | American journal of physiology. Gastrointestinal and liver physiology 20091201 |
| Adenosine 5'-triphosphate stimulates the increase of TGF-beta1 in rat mesangial cells under high-glucose conditions via reactive oxygen species and ERK1/2. | Acta pharmacologica Sinica 20091201 |
| Modulation of the activity of two pacemakers by transmural nerve stimulation in circular smooth muscle preparations isolated from the rat proximal colon. | Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20091201 |
| Blockade of P2X receptor prevents astroglial death in the dentate gyrus following pilocarpine-induced status epilepticus. | Neurological research 20091101 |
| Released nucleotides amplify the cilium-dependent, flow-induced [Ca2+]i response in MDCK cells. | Acta physiologica (Oxford, England) 20091101 |
| Activation of purinergic receptors by ATP induces ventricular tachycardia by membrane depolarization and modifications of Ca2+ homeostasis. | Journal of molecular and cellular cardiology 20091101 |
| Interaction of new, very potent non-nucleotide antagonists with Arg256 of the human platelet P2Y12 receptor. | The Journal of pharmacology and experimental therapeutics 20091101 |
| Extracellular ATP inhibits transport in medullary thick ascending limbs: role of P2X receptors. | American journal of physiology. Renal physiology 20091101 |
| East African trypanosomiasis in a pregnant traveler. | Emerging infectious diseases 20091101 |
| Heparin and suramin alter plitidepsin uptake via inhibition of GPCR coupled signaling. | Journal of chemotherapy (Florence, Italy) 20091101 |
| Identification and functional characterization of the intermediate-conductance Ca(2+)-activated K(+) channel (IK-1) in biliary epithelium. | American journal of physiology. Gastrointestinal and liver physiology 20091101 |
| Promoting MPhi transepithelial migration by stimulating the epithelial cell P2Y(2) receptor. | European journal of immunology 20091001 |
| ATP in the pathogenesis of lung emphysema. | European journal of pharmacology 20091001 |
| Involvement of sphingosine 1-phosphate (SIP)/S1P3 signaling in cholestasis-induced liver fibrosis. | The American journal of pathology 20091001 |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
| Activation of purinergic receptors induces proliferation and neuronal differentiation in Swiss Webster mouse olfactory epithelium. | Neuroscience 20090929 |
| In vitro interaction between suramin and fluvastatin against clinically important Zygomycetes. | Mycoses 20090901 |
| Neurokinin 1 receptor activates transient receptor potential-like currents in noradrenergic A7 neurons in rats. | Molecular and cellular neurosciences 20090901 |
| Allosteric interaction of the anticholinergic drug [N-(4-phenyl)-phenacyl-l-hyoscyamine] (Phenthonium) with nicotinic receptors of post-ganglionic sympathetic neurons of the rat vas deferens. | European journal of pharmacology 20090815 |
| P2X antagonists inhibit styryl dye entry into hair cells. | Neuroscience 20090721 |
| VEGF recruits lactosylceramide to induce endothelial cell adhesion molecule expression and angiogenesis in vitro and in vivo. | Glycoconjugate journal 20090701 |
| Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein. | The Journal of pharmacology and experimental therapeutics 20090601 |
| Structural and thermodynamic analysis of thrombin:suramin interaction in solution and crystal phases. | Biochimica et biophysica acta 20090601 |
| Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis. | Journal of hepatology 20090601 |
| In vitro and in vivo antitrypanosomal activities of three peptide antibiotics: leucinostatin A and B, alamethicin I and tsushimycin. | The Journal of antibiotics 20090601 |
| Modulation of firing activity by ATP in dopamine neurons of the rat substantia nigra pars compacta. | Neuroscience 20090519 |
| Purinergic receptor activation evokes neurotrophic factor neuropeptide Y release from neonatal mouse olfactory epithelial slices. | Journal of neuroscience research 20090501 |
| Extracellular ATP and P2 receptors are required for IL-8 to induce neutrophil migration. | Cytokine 20090501 |
| Uridine-5'-triphosphate protects against hepatic- ischemic/reperfusion injury in mice. | Transplantation 20090427 |
| Astrocyte cultures exhibit P2X7 receptor channel opening in the absence of exogenous ligands. | Glia 20090415 |
| Purinergic signaling in the pulmonary neuroepithelial body microenvironment unraveled by live cell imaging. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090401 |
| Suramin inhibits macrophage activation by human group IIA phospholipase A2, but does not affect bactericidal activity of the enzyme. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20090401 |
| Mapping of suramin binding sites on the group IIA human secreted phospholipase A2. | Bioorganic chemistry 20090401 |
| Suramin inhibits the CD40-CD154 costimulatory interaction: a possible mechanism for immunosuppressive effects. | Biochemical pharmacology 20090401 |
| CE can identify small molecules that selectively target soluble oligomers of amyloid beta protein and display antifibrillogenic activity. | Electrophoresis 20090401 |
| Angiogenesis inhibition causes hypertension and placental dysfunction in a rat model of preeclampsia. | Journal of hypertension 20090401 |
| Regulation of adenosine 5'-triphosphate (ATP)-gated P2X(4) receptors on tracheal smooth muscle cells. | Respiratory physiology & neurobiology 20090331 |
| Ca(2+)-calmodulin can activate and inactivate cardiac ryanodine receptors. | British journal of pharmacology 20090301 |
| Structure and function of Pseudomonas aeruginosa protein PA1324 (21-170). | Protein science : a publication of the Protein Society 20090301 |
| Investigation of the role of adrenergic and non-nitrergic, non-adrenergic neurotransmission in the sheep isolated internal anal sphincter. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20090301 |
| Suramin promotes recovery from renal ischemia/reperfusion injury in mice. | Kidney international 20090201 |
| Native ion current coupled to purinergic activation via basal and mechanically induced ATP release in Xenopus follicles. | Journal of cellular physiology 20090201 |
| A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP. | American journal of physiology. Cell physiology 20090201 |
| P2Y receptors mediate Ca2+ signaling in duodenocytes and contribute to duodenal mucosal bicarbonate secretion. | American journal of physiology. Gastrointestinal and liver physiology 20090201 |
| Ciliary body toxicity of subconjunctival suramin compared with mitomycin-C in the rabbit eye: determining the toxic concentration. | Ophthalmic research 20090101 |
| CrATP as a new inhibitor of ecto-ATPases of trypanosomatids. | Parasitology 20090101 |
| [Agents for the treatment of African sleeping sickness. Those developed in the last century]. | Pharmazie in unserer Zeit 20090101 |
| Spontaneous Ca2+ oscillations via purinergic receptors elicit transient cell swelling in rat parotid ducts. | The journal of medical investigation : JMI 20090101 |
| Capillary electrophoresis in drug discovery. | Methods in molecular biology (Clifton, N.J.) 20090101 |
| Role of TRP channels and NCX in mediating hypoxia-induced [Ca(2+)](i) elevation in PC12 cells. | Respiratory physiology & neurobiology 20081231 |
| Activation of cholinergic receptors blocks non-adrenergic non-cholinergic contractions in the rat urinary bladder. | Brain research bulletin 20081216 |
| Ca2+ oscillation induced by P2Y2 receptor activation and its regulation by a neuron-specific subtype of PKC (gammaPKC). | Neuroscience letters 20081203 |
| Improved muscle healing after contusion injury by the inhibitory effect of suramin on myostatin, a negative regulator of muscle growth. | The American journal of sports medicine 20081201 |
| Alteration of cholinergic, purinergic and sensory neurotransmission in the mouse colon of food allergy model. | Neuroscience letters 20081121 |
| Sustained depolarization-induced propagation of [Ca2+]i oscillations in cultured DRG neurons: the involvement of extracellular ATP and P2Y receptor activation. | Brain research 20081106 |
| ATP activates P2x receptors and requires extracellular Ca(++) participation to modify outer hair cell nonlinear capacitance. | Pflugers Archiv : European journal of physiology 20081101 |
| Luminal ATP-induced contraction of rabbit pulmonary arteries and role of purinoceptors in the regulation of pulmonary arterial pressure. | Pflugers Archiv : European journal of physiology 20081101 |
| Volume-activated chloride channels in mice Leydig cells. | Pflugers Archiv : European journal of physiology 20081101 |
| Purine receptor antagonist modulates serology and affective behaviors in lupus-prone mice: evidence of autoimmune-induced pain? | Brain, behavior, and immunity 20081101 |
| Noncytotoxic suramin as a chemosensitizer in patients with advanced non-small-cell lung cancer: a phase II study. | Annals of oncology : official journal of the European Society for Medical Oncology 20081101 |
| MDA-MB-231 produces ATP-mediated ICAM-1-dependent facilitation of the attachment of carcinoma cells to human lymphatic endothelial cells. | American journal of physiology. Cell physiology 20081101 |
| Suramin: clinical uses and structure-activity relationships. | Mini reviews in medicinal chemistry 20081101 |
| Ectodomain lysines and suramin block of P2X1 receptors. | The Journal of biological chemistry 20081031 |
| Endogenous ATP potentiates only vasopressin secretion from neurohypophysial terminals. | Journal of cellular physiology 20081001 |
| High-frequency fatigue of skeletal muscle: role of extracellular Ca(2+). | European journal of applied physiology 20081001 |
| Purinergic type 2 receptors at GABAergic synapses on ventral tegmental area dopamine neurons are targets for ethanol action. | The Journal of pharmacology and experimental therapeutics 20081001 |
| Structural characterization of myotoxic ecarpholin S from Echis carinatus venom. | Biophysical journal 20081001 |
| A universal method for fishing target proteins from mixtures of biomolecules using isothermal titration calorimetry. | Protein science : a publication of the Protein Society 20081001 |
| Serotonin increases GABA release in rat entorhinal cortex by inhibiting interneuron TASK-3 K+ channels. | Molecular and cellular neurosciences 20081001 |
| Demonstration and partial characterization of ecto-ATPase in Balamuthia mandrillaris and its possible role in the host-cell interactions. | Letters in applied microbiology 20081001 |
| Dual effect of ATP on glucose-induced insulin secretion in HIT-T15 cells. | Pancreas 20081001 |
| Angiogenesis: an improved in vitro biological system and automated image-based workflow to aid identification and characterization of angiogenesis and angiogenic modulators. | Assay and drug development technologies 20081001 |
| Ca2+ signaling in injured in situ endothelium of rat aorta. | Cell calcium 20080901 |
| Adenine nucleotide changes in the remnant liver: An early signal for regeneration after partial hepatectomy. | Hepatology (Baltimore, Md.) 20080901 |
| Phase I/II trial of 5-fluorouracil and a noncytotoxic dose level of suramin in patients with metastatic renal cell carcinoma. | Clinical genitourinary cancer 20080901 |
| Stimulation of alpha2-adrenoceptors suppresses excitatory synaptic transmission in the medial prefrontal cortex of rat. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20080801 |
| P2X7 receptor as sensitive flow sensor for ERK activation in osteoblasts. | Biochemical and biophysical research communications 20080801 |
| Dinucleotide polyphosphates contribute to purinergic signalling via inhibition of adenylate kinase activity. | Bioscience reports 20080801 |
| Connexin45 is expressed in the juxtaglomerular apparatus and is involved in the regulation of renin secretion and blood pressure. | American journal of physiology. Regulatory, integrative and comparative physiology 20080801 |
| Pharmacological properties of P2 receptors on rat otic parasympathetic ganglion neurons. | Life sciences 20080801 |
| The inhibitory effect of suramin on telomerase activity and spheroid growth of C6 glioma cells. | Medical science monitor : international medical journal of experimental and clinical research 20080801 |
| The effect of sildenafil on the altered thoracic aorta smooth muscle responses in rat pre-eclampsia model. | European journal of pharmacology 20080728 |
| Acute inhibition of the betaine transporter by ATP and adenosine in renal MDCK cells. | American journal of physiology. Renal physiology 20080701 |
| Prostacyclin induction by high-density lipoprotein (HDL) in vascular smooth muscle cells depends on sphingosine 1-phosphate receptors: effect of simvastatin. | Thrombosis and haemostasis 20080701 |
| Lysyl oxidase (LOX) mRNA expression and genes of the differentiated osteoblastic phenotype are upregulated in human osteosarcoma cells by suramin. | Cancer letters 20080628 |
| Connexin 40 and ATP-dependent intercellular calcium wave in renal glomerular endothelial cells. | American journal of physiology. Regulatory, integrative and comparative physiology 20080601 |
| Giardia lamblia: biochemical characterization of an ecto-ATPase activity. | Experimental parasitology 20080601 |
| The effects of suramin in prevention of peritendinous adhesions following flexor tendon injury in a chicken model. | Orthopedics 20080601 |
| Glutamate release and synapsin-I phosphorylation induced by P2X7 receptors activation in cerebellar granule neurons. | Neurochemistry international 20080501 |
| Selective activation of peroxisome proliferator-activated receptor (PPAR)alpha and PPAR gamma induces neoangiogenesis through a vascular endothelial growth factor-dependent mechanism. | Diabetes 20080501 |
| Intravital microscopic characterization of suramin effects in an orthotopic immunocompetent rat model of pancreatic cancer. | Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20080501 |
| Involvement of apical P2Y2 receptor-regulated CFTR activity in muscarinic stimulation of Cl(-) reabsorption in rat submandibular gland. | American journal of physiology. Regulatory, integrative and comparative physiology 20080501 |
| Small-conductance, Ca(2+) -activated K+ channel 2 is the key functional component of SK channels in mouse urinary bladder. | American journal of physiology. Regulatory, integrative and comparative physiology 20080501 |
| Binding of liver derived, low density hepatitis C virus to human hepatoma cells. | Journal of medical virology 20080501 |
| Secreted protein acidic, rich in cysteine induces pulp cell migration via alphavbeta3 integrin and extracellular signal-regulated kinase. | Oral diseases 20080501 |
| A positive inotropic effect of ATP in the human cardiac atrium. | American journal of physiology. Heart and circulatory physiology 20080401 |
| Suramin and minocycline treatment of experimental African trypanososmiasis at an early stage of parasite brain invasion. | Acta tropica 20080401 |
| [Inhibitory effects of suramin on growth of transplanted lung adencarcinoma in mice and its mechanisms]. | Ai zheng = Aizheng = Chinese journal of cancer 20080401 |
| Long-term modulation of tyrosine hydroxylase activity and expression by endothelin-1 and -3 in the rat anterior and posterior hypothalamus. | American journal of physiology. Regulatory, integrative and comparative physiology 20080301 |
| In vitro effects of suramin on Trypanosoma cruzi. | International journal of antimicrobial agents 20080301 |
| Involvement of purinergic P2 receptors in experimental retinal neovascularization. | Current eye research 20080301 |
| Single-channel characterization of the rabbit recombinant RyR2 reveals a novel inactivation property of physiological concentrations of ATP. | The Journal of membrane biology 20080301 |
| E-NTPDases and ecto-5'-nucleotidase expression profile in rat heart left ventricle and the extracellular nucleotide hydrolysis by their nerve terminal endings. | Life sciences 20080227 |
| Cloning and pharmacological characterization of the guinea pig P2X7 receptor orthologue. | British journal of pharmacology 20080201 |
| [Extracorporeal Circulation; Historical aspects; Part II]. | The Thoracic and cardiovascular surgeon 20080201 |
| Role of TNF-alpha and extracellular ATP in THP-1 cell activation following allergen exposure. | The Journal of toxicological sciences 20080201 |
| FTY720 modulates human oligodendrocyte progenitor process extension and survival. | Annals of neurology 20080101 |
| Zymogen activation, inhibition, and ectodomain shedding of matriptase. | Frontiers in bioscience : a journal and virtual library 20080101 |
| Ability of suramin to antagonize the cardiotoxic and some enzymatic activities of Bothrops jararacussu venom. | Toxicon : official journal of the International Society on Toxinology 20080101 |
| Micro-electrode flux estimation confirms that the Solanum pimpinellifolium cu3 mutant still responds to systemin. | Plant physiology 20080101 |
| Suramin induces and enhances apoptosis in a model of hyperoxia-induced oligodendrocyte injury. | Neurotoxicity research 20080101 |
| Biochemical and structural investigations of Bothropstoxin-II, a myotoxic Asp49 phospholipase A2 from Bothrops jararacussu venom. | Protein and peptide letters 20080101 |
| African trypanosomiasis in two short-term Australian travelers to Malawi. | Journal of travel medicine 20080101 |
| Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor. | Journal of immunology (Baltimore, Md. : 1950) 20071215 |
| Inhibitory purinergic transmission in mouse caecum: role for P2Y1 receptors as prejunctional modulators of ATP release. | Neuroscience 20071212 |
| Biochemical characterization of ecto-nucleotide pyrophosphatase/phosphodiesterase (E-NPP, E.C. 3.1.4.1) from rat heart left ventricle. | Molecular and cellular biochemistry 20071201 |
| P2Y2 nucleotide receptors inhibit trauma-induced death of astrocytic cells. | Journal of neurochemistry 20071201 |
| Thr339-to-serine substitution in rat P2X2 receptor second transmembrane domain causes constitutive opening and indicates a gating role for Lys308. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20071121 |
| Inhibition of human and mouse plasma membrane bound NTPDases by P2 receptor antagonists. | Biochemical pharmacology 20071115 |
| Downregulation of SGK1 by nucleotides in renal tubular epithelial cells. | American journal of physiology. Renal physiology 20071101 |
| Effect of suramin on the human pathogen Candida albicans: implications on the fungal development and virulence. | FEMS immunology and medical microbiology 20071101 |
| Cyclic AMP regulates bicarbonate secretion in cholangiocytes through release of ATP into bile. | Gastroenterology 20071101 |
| Ca2+-dependent ATP release from A549 cells involves synergistic autocrine stimulation by coreleased uridine nucleotides. | The Journal of physiology 20071015 |
| Suramin augments the antitumor and antimetastatic activity of pentoxifylline in B16F10 melanoma. | International journal of cancer 20071001 |
| Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (sirtuins). | ChemMedChem 20071001 |
| Sympathetic vasoconstrictor regulation of mouse colonic submucosal arterioles is altered in experimental colitis. | The Journal of physiology 20070901 |
| Strategies for eliminating PrP(c) as substrate for prion conversion and for enhancing PrP(Sc) degradation. | Veterinary microbiology 20070831 |
| Cisplatin cytotoxicity in organ of Corti-derived immortalized cells. | Journal of cellular biochemistry 20070801 |
| Lysophospholipids regulate excitability and exocytosis in cultured bovine chromaffin cells. | Journal of neurochemistry 20070801 |
| Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells. | Nature medicine 20070801 |
| Hyposmotic stimulation-induced nitric oxide production in outer hair cells of the guinea pig cochlea. | Hearing research 20070801 |
| Immobilized P2X2 purinergic receptor stationary phase for chromatographic determination of pharmacological properties and drug screening. | Journal of pharmaceutical and biomedical analysis 20070727 |
| ATP modulates the release of noradrenaline through two different prejunctional receptors on the adrenergic nerves of rat prostate. | Clinical and experimental pharmacology & physiology 20070701 |
| African trypanosomiasis in a British soldier. | Military medicine 20070701 |
| Directed molecular screening for RecA ATPase inhibitors. | Bioorganic & medicinal chemistry letters 20070615 |
| P2 purinoceptor antagonists inhibit the non-adrenergic, non-cholinergic relaxation of the human colon in vitro. | Neuroscience 20070615 |
| Purinergic actions on neurons that modulate nociception in the rostral ventromedial medulla. | Neuroscience 20070608 |
| Suramin counteracts the haemostatic disturbances produced by Bothrops jararaca snake venom. | Toxicon : official journal of the International Society on Toxinology 20070601 |
| Treatment failure related to intrathecal immunoglobulin M (IgM) synthesis, cerebrospinal fluid IgM, and interleukin-10 in patients with hemolymphatic-stage sleeping sickness. | Clinical and vaccine immunology : CVI 20070601 |
| Extracellular ATP in activity-dependent remodeling of the neuromuscular junction. | Developmental neurobiology 20070601 |
| Peripheral oxygen-sensing cells directly modulate the output of an identified respiratory central pattern generating neuron. | The European journal of neuroscience 20070601 |
| P19 embryonal carcinoma cells as in vitro model for studying purinergic receptor expression and modulation of N-methyl-D-aspartate-glutamate and acetylcholine receptors during neuronal differentiation. | Neuroscience 20070525 |
| Smooth muscle and neural mechanisms contributing to the downregulation of neonatal rat spontaneous bladder contractions during postnatal development. | American journal of physiology. Regulatory, integrative and comparative physiology 20070501 |
| Identification of a second blocker binding site at the cytoplasmic mouth of the cystic fibrosis transmembrane conductance regulator chloride channel pore. | Molecular pharmacology 20070501 |
| Suprasternal gland secretion of male short-tailed opossum induces IP3 generation in the vomeronasal organ. | Biochimica et biophysica acta 20070501 |
| Carotid body chemosensory activity and ventilatory chemoreflexes in cats persist after combined cholinergic-purinergic block. | Respiratory physiology & neurobiology 20070416 |
| Effects of combined cholinergic-purinergic block upon cat carotid body chemoreceptors in vitro. | Respiratory physiology & neurobiology 20070416 |
| Mitogen-activated protein kinase signaling is involved in suramin-induced neurite outgrowth in a neuronal cell line. | Biochemical and biophysical research communications 20070413 |
| Incorporation of lycopene into chylomicron remnant-like particles inhibits their uptake by HepG2 cells. | Life sciences 20070410 |
| Purinergic control of the quail rectum: modulation of adenosine 5'-triphosphate-mediated contraction with acetylcholine. | Research in veterinary science 20070401 |
| Trypanosoma brucei brucei: biochemical characterization of ecto-nucleoside triphosphate diphosphohydrolase activities. | Experimental parasitology 20070401 |
| Extracellular ATP is involved in the induction of apoptosis in murine hematopoietic cells. | Biological & pharmaceutical bulletin 20070401 |
| Direct and indirect effects of mutations at the outer mouth of the cystic fibrosis transmembrane conductance regulator chloride channel pore. | The Journal of membrane biology 20070401 |
| Antitrypanosomal activity of quaternary naphthalimide derivatives. | Bioorganic & medicinal chemistry letters 20070315 |
| Parasporin-1, a novel cytotoxic protein from Bacillus thuringiensis, induces Ca2+ influx and a sustained elevation of the cytoplasmic Ca2+ concentration in toxin-sensitive cells. | The Journal of biological chemistry 20070309 |
| Origin of spontaneous activity in neonatal and adult rat bladders and its enhancement by stretch and muscarinic agonists. | American journal of physiology. Renal physiology 20070301 |
| Interfacial surface charge and free accessibility to the PLA2-active site-like region are essential requirements for the activity of Lys49 PLA2 homologues. | Toxicon : official journal of the International Society on Toxinology 20070301 |
| Evidence for the expression of multiple uracil nucleotide-stimulated P2 receptors coupled to smooth muscle contraction in porcine isolated arteries. | British journal of pharmacology 20070301 |
| Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin. | Structure (London, England : 1993) 20070301 |
| Trypanosoma evansi infections in Himalayan black bears (Selenarctos thibetanus). | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20070301 |
| Extracellular ATP has stimulatory effects on the expression and release of IL-6 via purinergic receptors in normal human epidermal keratinocytes. | The Journal of investigative dermatology 20070201 |
| In vitro characterization of parasympathetic and sympathetic responses in cyclophosphamide-induced cystitis in the rat. | Basic & clinical pharmacology & toxicology 20070201 |
| Alterations of adenine nucleotide metabolism and function of blood platelets in patients with diabetes. | Diabetes 20070201 |
| Suramin inhibits not only tumor growth and metastasis but also angiogenesis in experimental pancreatic cancer. | Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20070201 |
| Identification of atropine- and P2X1 receptor antagonist-resistant, neurogenic contractions of the urinary bladder. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20070124 |
| Albumin-bound lipids induce free cytoplasmic calcium oscillations in human osteoblast-like cells. | Cell biochemistry and function 20070101 |
| Characterization of functional P2X(1) receptors in mouse megakaryocytes. | Thrombosis research 20070101 |
| Suramin-restricted blood volume in the placenta of normal and diabetic rats is normalized by vitamin E treatment. | Placenta 20070101 |
| Frequency encoding of cholinergic- and purinergic-mediated signaling to mouse urinary bladder smooth muscle: modulation by BK channels. | American journal of physiology. Regulatory, integrative and comparative physiology 20070101 |
| Differentiation-dependent alterations in the extracellular ATP-evoked calcium fluxes of cultured skeletal muscle cells from mice. | Pflugers Archiv : European journal of physiology 20070101 |
| Different ways to antiangiogenesis by angiostatin and suramin, and quantitation of angiostatin-induced antiangiogenesis. | APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20070101 |
| Activation-dependent trafficking of NTPDase2 in Chinese hamster ovary cells. | The international journal of biochemistry & cell biology 20070101 |
| Follicle stimulating hormone receptor (FSHR) antagonist and epithelial ovarian cancer (EOC). | Journal of experimental therapeutics & oncology 20070101 |
| UV-B-induced signaling events leading to enhanced-production of catharanthine in Catharanthus roseus cell suspension cultures. | BMC plant biology 20070101 |
| ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors. | Science (New York, N.Y.) 20061215 |
| Purinergic nerves mediate the non-nitrergic relaxation of the human ileum in response to electrical field stimulation. | Brain research bulletin 20061211 |
| Purinergic pathway suppresses the release of .NO and stimulates proteoglycan synthesis in chondrocyte/agarose constructs subjected to dynamic compression. | Journal of cellular physiology 20061201 |
| NANC inhibitory neuromuscular transmission in the hamster distal colon. | Pharmacological research 20061201 |
| The minimal amyloid-forming fragment of the islet amyloid polypeptide is a glycolipid-binding domain. | The FEBS journal 20061201 |
| The co-treatments of vigabatrin and P2X receptor antagonists protect ischemic neuronal cell death in the gerbil hippocampus. | Brain research 20061120 |
| Gap junctional intercellular communication in bovine corneal endothelial cells. | Experimental eye research 20061101 |
| Uracil nucleotides stimulate human neural precursor cell proliferation and dopaminergic differentiation: involvement of MEK/ERK signalling. | Journal of neurochemistry 20061101 |
| P2 purinergic receptors signal to STAT3 in astrocytes: Difference in STAT3 responses to P2Y and P2X receptor activation. | Neuroscience 20061013 |
| Treatment and follow-up of the first case of human trypanosomiasis caused by Trypanosoma evansi in India. | Transactions of the Royal Society of Tropical Medicine and Hygiene 20061001 |
| Bisphosphonates activate nucleotide receptors signaling and induce the expression of Hsp90 in osteoblast-like cell lines. | Bone 20061001 |
| PRL-3 initiates tumor angiogenesis by recruiting endothelial cells in vitro and in vivo. | Cancer research 20061001 |
| Presynaptic inhibition of spontaneous acetylcholine release mediated by P2Y receptors at the mouse neuromuscular junction. | Neuroscience 20060929 |
| Reactive blue 2, an antagonist of rat P2Y4, increases K+ secretion in rat cochlea strial marginal cells. | Hearing research 20060901 |
| A woman with fever and rash after African safari. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060901 |
| Hypotonic stress activates BK channels in clonal kidney cells via purinergic receptors, presumably of the P2Y subtype. | Acta physiologica (Oxford, England) 20060901 |
| Biochemical characterization of suramin as a selective inhibitor for the PKA-mediated phosphorylation of HBV core protein in vitro. | Biological & pharmaceutical bulletin 20060901 |
| African trypanosomiasis in a British soldier. | Journal of the Royal Army Medical Corps 20060901 |
| Altered neurogenic and mechanical responses to acetylcholine, ATP and substance P in detrusor from rat with outlet obstruction. | Life sciences 20060822 |
| Sympathetic neurotransmission in the rat testicular capsule: functional characterization and identification of mRNA encoding alpha1-adrenoceptor subtypes. | European journal of pharmacology 20060814 |
| Distinct mono- and dinucleotide-specific P2Y receptors in A549 lung epithelial cells: different control of arachidonic acid release and nitric oxide synthase expression. | European journal of pharmacology 20060814 |
| Activation of Src/kinase/phospholipase C/mitogen-activated protein kinase and induction of neurite expression by ATP, independent of nerve growth factor. | Neuroscience 20060811 |
| Defective nitric oxide-dependent, deaminative cleavage of glypican-1 heparan sulfate in Niemann-Pick C1 fibroblasts. | Glycobiology 20060801 |
| Local regulation of skin blood flow during cooling involving presynaptic P2 purinoceptors in rats. | British journal of pharmacology 20060701 |
| ATP stimulates interleukin-6 production via P2Y receptors in human HaCaT keratinocytes. | European journal of pharmacology 20060701 |
| Increased expression of insulin-like growth factor i is associated with Ara-C resistance in leukemia. | The Tohoku journal of experimental medicine 20060701 |
| Investigation of the mechanism for the relaxation of rat duodenum mediated via M1 muscarinic receptors. | Autonomic & autacoid pharmacology 20060701 |
| Heterogeneous response of microvascular endothelial cells to shear stress. | American journal of physiology. Heart and circulatory physiology 20060601 |
| The effect of TAO expression on PCD-like phenomenon development and drug resistance in Trypanosoma brucei. | Parasitology international 20060601 |
| The suramin analog 4,4',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis (carbonylimino)))tetra-kis-benzenesulfonic acid (NF110) potently blocks P2X3 receptors: subtype selectivity is determined by location of sulfonic acid groups. | Molecular pharmacology 20060601 |
| Nontoxic suramin as a chemosensitizer in patients: dosing nomogram development. | Pharmaceutical research 20060601 |
| Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents. | Bioorganic & medicinal chemistry letters 20060515 |
| Suramin-induced reciprocal changes in glucose and lactate synthesis in renal tubules contribute to its hyperglycaemic action. | European journal of pharmacology 20060510 |
| Biochemical and immunochemical characterisation of human diadenosine triphosphatase provides evidence for its identification with the tumour suppressor Fhit protein. | Biochimie 20060501 |
| Inhibition by suramin of protein synthesis in vitro. Ribosomes as the target of the drug. | Biochimie 20060501 |
| ATPgammaS enhances the production of inflammatory mediators by a human dermal endothelial cell line via purinergic receptor signaling. | The Journal of investigative dermatology 20060501 |
| Transverse myelitis due to trypanosomiasis in a middle aged Tanzanian man. | Journal of neurology, neurosurgery, and psychiatry 20060501 |
| Effect of suramin on trypomastigote forms of Trypanosoma cruzi: changes on cell motility and on the ultrastructure of the flagellum-cell body attachment region. | Acta tropica 20060501 |
| Schwann cells in rat vascular autonomic nerves activated via purinergic receptors. | Neuroreport 20060403 |
| P2X receptors in mouse Leydig cells. | American journal of physiology. Cell physiology 20060401 |
| [Effects of suramin in combination with cisplatin on growth and metastasis of lung adenocarcinoma xenografts in mice]. | Ai zheng = Aizheng = Chinese journal of cancer 20060401 |
| Role of protein kinase C, G-protein coupled receptors, and calcium flux during metamorphosis of the sea urchin Strongylocentrotus purpuratus. | The Biological bulletin 20060401 |
| Role of protein kinase C in the effect of ATP on contractile function of the isolated strip from mouse diaphragm. | Bulletin of experimental biology and medicine 20060401 |
| Extracellular ATP stimulates NO production in rat thick ascending limb. | Hypertension (Dallas, Tex. : 1979) 20060301 |
| Ecto-nucleotide pyrophosphatase/phosphodiesterase as part of a multiple system for nucleotide hydrolysis by platelets from rats: kinetic characterization and biochemical properties. | Platelets 20060301 |
| High phosphorylation of HBV core protein by two alpha-type CK2-activated cAMP-dependent protein kinases in vitro. | FEBS letters 20060206 |
| Changes in purinergic signalling in developing and ageing rat tail artery: importance for temperature control. | Neuropharmacology 20060201 |
| Trypanosoma rangeli: characterization of a Mg-dependent ecto ATP-diphosphohydrolase activity. | Experimental parasitology 20060201 |
| Extracellular ATP-stimulated current in wild-type and P2X4 receptor transgenic mouse ventricular myocytes: implications for a cardiac physiologic role of P2X4 receptors. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060201 |
| Drug-resistance of Trypanosoma b. rhodesiense isolates from Tanzania. | Tropical medicine & international health : TM & IH 20060201 |
| Activation of P2Y receptor enhances high-molecular compound absorption from rat ileum. | The Journal of pharmacy and pharmacology 20060201 |
| Understanding the mechanism of the antimitogenic activity of suramin. | Biochemistry 20060124 |
| Inhibition mechanism of the recombinant rat P2X(2) receptor in glial cells by suramin and TNP-ATP. | Biochemistry 20060110 |
| Suramin prevents fulminant hepatic failure resulting in reduction of lethality through the suppression of NF-kappaB activity. | Cytokine 20060107 |
| Orchitis as an unusual manifestation of human African trypanosomiasis. | The Journal of infection 20060101 |
| Augmented extracellular ATP signaling in bladder urothelial cells from patients with interstitial cystitis. | American journal of physiology. Cell physiology 20060101 |
| Effect of ATP on preadipocyte migration and adipocyte differentiation by activating P2Y receptors in 3T3-L1 cells. | The Biochemical journal 20060101 |
| Enhanced neurally evoked responses and inhibition of norepinephrine reuptake in rat mesenteric arteries after spinal transection. | American journal of physiology. Heart and circulatory physiology 20060101 |
| Purinoceptors are involved in the induction of an osmolyte permeability in malaria-infected and oxidized human erythrocytes. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060101 |
| Antiviral effect of the heparan sulfate mimetic, PI-88, against dengue and encephalitic flaviviruses. | Antiviral research 20060101 |
| Microglial morphology and its transformation after challenge by extracellular ATP in vitro. | Journal of neuroscience research 20060101 |
| Spontaneous oscillation and mechanically induced calcium waves in chondrocytes. | Cell biochemistry and function 20060101 |
| Circumvention of camptothecin-induced resistance during the adaptive cellular stress response. | Anticancer research 20060101 |
| Depression of presynaptic excitation by the activation of vanilloid receptor 1 in the rat spinal dorsal horn revealed by optical imaging. | Molecular pain 20060101 |
| A rare case of human trypanosomiasis caused by Trypanosoma evansi. | Indian journal of medical microbiology 20060101 |
| Purinergic substances promote murine keratinocyte proliferation and enhance impaired wound healing in mice. | Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20060101 |
| Osmoregulation of taurine efflux from cultured human breast cancer cells: comparison with volume activated Cl- efflux and regulation by extracellular ATP. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20060101 |
| Phase I evaluation of low-dose suramin as chemosensitizer of doxorubicin in dogs with naturally occurring cancers. | Journal of veterinary internal medicine 20060101 |
| The effect of P2X receptor activity on GABAA receptor-mediated inhibition in the gerbil hippocampus. | Brain research 20051214 |
| Modulation of agonist binding to human dopamine receptor subtypes by L-prolyl-L-leucyl-glycinamide and a peptidomimetic analog. | The Journal of pharmacology and experimental therapeutics 20051201 |
| Neurally released ATP mediates endothelium-dependent hyperpolarization in the circular smooth muscle cells of chicken anterior mesenteric artery. | British journal of pharmacology 20051201 |
| Interactions of charged ligands with beta(2)-microglobulin conformers in affinity capillary electrophoresis. | Biochimica et biophysica acta 20051110 |
| Synthesis and structure-activity relationships of suramin-derived P2Y11 receptor antagonists with nanomolar potency. | Journal of medicinal chemistry 20051103 |
| Rho kinase inhibitors reduce neurally evoked contraction of the rat tail artery in vitro. | British journal of pharmacology 20051101 |
| Search of ligands for the amyloidogenic protein beta2-microglobulin by capillary electrophoresis and other techniques. | Electrophoresis 20051101 |
| Charged bipolar suramin derivatives induce aggregation of the prion protein at the cell surface and inhibit PrPSc replication. | Journal of cell science 20051101 |
| Neocuproine, a copper (I) chelator, potentiates purinergic component of vas deferens contractions elicited by electrical field stimulation. | Pharmacology 20051001 |
| Use-dependent inhibition of the skeletal muscle ryanodine receptor by the suramin analogue NF676. | British journal of pharmacology 20051001 |
| Apoptosis modulates protective immunity to the pathogenic fungus Histoplasma capsulatum. | The Journal of clinical investigation 20051001 |
| Involvement of nitric oxide pathways in short term modulation of tyrosine hydroxylase activity by endothelins 1 and 3 in the rat anterior hypothalamus. | Biochemical and biophysical research communications 20050902 |
| Intrinsic inhibitory innervation of the stomach. | British journal of pharmacology 20050901 |
| Direct excitation of hypocretin/orexin cells by extracellular ATP at P2X receptors. | Journal of neurophysiology 20050901 |
| P2 receptor blockade attenuates fever and cytokine responses induced by lipopolysaccharide in rats. | British journal of pharmacology 20050901 |
| Endogenous opioid mechanisms partially mediate P2X3/P2X2/3-related antinociception in rat models of inflammatory and chemogenic pain but not neuropathic pain. | British journal of pharmacology 20050901 |
| Human trypanosomiasis caused by Trypanosoma evansi in India: the first case report. | The American journal of tropical medicine and hygiene 20050901 |
| [Anti-angiogenesis treatment for brain tumors--present and future]. | Nihon rinsho. Japanese journal of clinical medicine 20050901 |
| Structural basis for antagonism by suramin of heparin binding to vaccinia complement protein. | Biochemistry 20050816 |
| On the nature and origin of DNA strand breaks in elongating spermatids. | Biology of reproduction 20050801 |
| The morphogenesis of the exstrophy-epispadias complex: a new concept based on observations made in early embryonic cases of cloacal exstrophy. | Anatomy and embryology 20050801 |
| Inhibition of myotoxic activity of Bothrops asper myotoxin II by the anti-trypanosomal drug suramin. | Journal of molecular biology 20050715 |
| Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050706 |
| Suramin promotes proliferation and scattering of renal epithelial cells. | The Journal of pharmacology and experimental therapeutics 20050701 |
| Suramin and disulfonated stilbene derivatives stimulate the Ca2+-induced Ca2+ -release mechanism in A7r5 cells. | Molecular pharmacology 20050701 |
| Low dose suramin as a chemosensitizer of bladder cancer to mitomycin C. | The Journal of urology 20050701 |
| Characterization of ATP and ADP hydrolysis activity in rat gastric mucosa. | Cell biology international 20050701 |
| Nontoxic suramin treatments enhance docetaxel activity in chemotherapy-pretreated non-small cell lung xenograft tumors. | Pharmaceutical research 20050701 |
| Characterization of [3H]-forskolin binding sites in young and adult rat brain cortex: identification of suramin as a competitive inhibitor of [3H]-forskolin binding. | Canadian journal of physiology and pharmacology 20050701 |
| H2O2 induces paracellular permeability of porcine brain-derived microvascular endothelial cells by activation of the p44/42 MAP kinase pathway. | European journal of cell biology 20050701 |
| The novel suramin analogue NF864 selectively blocks P2X1 receptors in human platelets with potency in the low nanomolar range. | Naunyn-Schmiedeberg's archives of pharmacology 20050701 |
| Inhibition of proteinase 3 (PR3) by suramin and fetal calf serum (FCS): effect of PR3 and suramin on Chinese hamster ovary cells (CHO-cells). | Pakistan journal of pharmaceutical sciences 20050701 |
| Cancer biology and hormesis: comments on Calabrese (2005). | Critical reviews in toxicology 20050701 |
| Mitogenic signaling by lysophosphatidic acid (LPA) involves Galpha12. | Oncogene 20050630 |
| Phase I trial of intravesical Suramin in recurrent superficial transitional cell bladder carcinoma. | British journal of cancer 20050620 |
| The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells. | The Biochemical journal 20050615 |
| The effect of a hyposmotic shock and purinergic agonists on K+(Rb+) efflux from cultured human breast cancer cells. | Biochimica et biophysica acta 20050615 |
| Calcium increases in retinal glial cells evoked by light-induced neuronal activity. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050608 |
| ATP released via gap junction hemichannels from the pigment epithelium regulates neural retinal progenitor proliferation. | Neuron 20050602 |
| Varicosity-Schwann cell interactions mediated by ATP in the mouse vas deferens. | Journal of neurophysiology 20050501 |
| Placental dysfunction in Suramin-treated rats--a new model for pre-eclampsia. | Placenta 20050501 |
| Involvement of uracil nucleotides in protection of cardiomyocytes from hypoxic stress. | Biochemical pharmacology 20050415 |
| Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells. | American journal of physiology. Cell physiology 20050401 |
| Suramin disrupts receptor-G protein coupling by blocking association of G protein alpha and betagamma subunits. | The Journal of pharmacology and experimental therapeutics 20050401 |
| Placental dysfunction in Suramin-treated rats: impact of maternal diabetes and effects of antioxidative treatment. | Journal of the Society for Gynecologic Investigation 20050401 |
| Clinical trials in metastatic prostate cancer--has there been real progress in the past decade? | European journal of cancer (Oxford, England : 1990) 20050401 |
| Robust quantification of in vitro angiogenesis through image analysis. | IEEE transactions on medical imaging 20050401 |
| G-protein coupled activation of potassium channels by endogenous neuropeptides in snail neurons. | The European journal of neuroscience 20050401 |
| Biological inactivation and impaired detection of IL-10 by suramin. | Journal of immunological methods 20050401 |
| Effect of neocuproine, a copper(i) chelator, on rat bladder function. | The Journal of pharmacology and experimental therapeutics 20050301 |
| An electrophysiological study of excitatory purinergic neuromuscular transmission in longitudinal smooth muscle of chicken anterior mesenteric artery. | British journal of pharmacology 20050301 |
| Profiling at recombinant homomeric and heteromeric rat P2X receptors identifies the suramin analogue NF449 as a highly potent P2X1 receptor antagonist. | Neuropharmacology 20050301 |
| Mechanisms of ATP action on motor nerve terminals at the frog neuromuscular junction. | The European journal of neuroscience 20050301 |
| The influence of hypothermia on P2 receptor-mediated responses of frog skeletal muscle. | European journal of pharmacology 20050221 |
| Biochemical and functional evidence for heteromeric assembly of P2X1 and P2X4 subunits. | Journal of neurochemistry 20050201 |
| Localization of intracellular calcium release in cells injured by venom from the ectoparasitoid Nasonia vitripennis (Walker) (Hymenoptera: Pteromalidae) and dependence of calcium mobilization on G-protein activation. | Journal of insect physiology 20050201 |
| Suramin interacts with RANK and inhibits RANKL-induced osteoclast differentiation. | Bone 20050201 |
| [The inhibiting effects of suramin on bFGF induced proliferation of cultured human RPE cells]. | [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20050201 |
| The use of suramin, an antifibrotic agent, to improve muscle recovery after strain injury. | The American journal of sports medicine 20050101 |
| Secretion of ATP from Schwann cells in response to uridine triphosphate. | The European journal of neuroscience 20050101 |
| Combination chemotherapy with docetaxel, estramustine and suramin for hormone refractory prostate cancer. | Urologic oncology 20050101 |
| Modulation of adenylyl cyclase activity in young and adult rat brain cortex. Identification of suramin as a direct inhibitor of adenylyl cyclase. | Journal of cellular and molecular medicine 20050101 |
| ATP inhibits pump activity of lymph vessels via adenosine A1 receptor-mediated involvement of NO- and ATP-sensitive K+ channels. | American journal of physiology. Heart and circulatory physiology 20041201 |
| Divergent effects of the purinoceptor antagonists suramin and pyridoxal-5'-phosphate-6-(2'-naphthylazo-6'-nitro-4',8'-disulfonate) (PPNDS) on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. | Molecular pharmacology 20041201 |
| Autoinhibition of transmitter release from PC12 cells and sympathetic neurons through a P2Y receptor-mediated inhibition of voltage-gated Ca2+ channels. | The European journal of neuroscience 20041201 |
| Evaluation of combination chemotherapy: integration of nonlinear regression, curve shift, isobologram, and combination index analyses. | Clinical cancer research : an official journal of the American Association for Cancer Research 20041201 |
| Crystallization and preliminary X-ray diffraction analysis of suramin, a highly charged polysulfonated napthylurea, complexed with a myotoxic PLA2 from Bothrops asper venom. | Biochimica et biophysica acta 20041201 |
| Quality of life impact of three different doses of suramin in patients with metastatic hormone-refractory prostate carcinoma: results of Intergroup O159/Cancer and Leukemia Group B 9480. | Cancer 20041115 |
| Cardiovascular responses to microinjection of ATP into the nucleus tractus solitarii of awake rats. | American journal of physiology. Regulatory, integrative and comparative physiology 20041101 |
| Evidence for P2Y1, P2Y2, P2Y6 and atypical UTP-sensitive receptors coupled to rises in intracellular calcium in mouse cultured superior cervical ganglion neurons and glia. | British journal of pharmacology 20041101 |
| Positive inotropic and sustained anti-beta-adrenergic effect of diadenosine pentaphosphate in human and guinea pig hearts. Role of dinucleotide receptors and adenosine receptors. | Acta physiologica Scandinavica 20041101 |
| Chemotherapy-induced peripheral neurotoxicity. | Expert opinion on drug safety 20041101 |
| A murine model of ex vivo angiogenesis using aortic disks grown in fibrin clot. | Microvascular research 20041101 |
| Ecto-ATPases of clinical and non-clinical isolates of Acanthamoeba. | Microbial pathogenesis 20041101 |
| Suramin as a chemosensitizer: oral pharmacokinetics in rats. | Pharmaceutical research 20041101 |
| Suramin interaction with human alpha-thrombin: inhibitory effects and binding studies. | The international journal of biochemistry & cell biology 20041001 |
| Nucleotide-mediated mucin secretion from differentiated human bronchial epithelial cells. | American journal of respiratory cell and molecular biology 20041001 |
| Role of macula densa adenosine triphosphate (ATP) in tubuloglomerular feedback. | Kidney international 20041001 |
| Suramin: potential in acute liver failure. | Expert opinion on investigational drugs 20041001 |
| The propeptide domain of lysyl oxidase induces phenotypic reversion of ras-transformed cells. | The Journal of biological chemistry 20040924 |
| Adenosine 5'-triphosphate and noradrenaline are excitatory cotransmitters to the fibromuscular stroma of the guinea pig prostate gland. | European journal of pharmacology 20040924 |
| Low-dose suramin enhanced paclitaxel activity in chemotherapy-naive and paclitaxel-pretreated human breast xenograft tumors. | Clinical cancer research : an official journal of the American Association for Cancer Research 20040915 |
| Role of extracellular histidines in antagonist sensitivity of the rat P2X4 receptor. | Neuroscience letters 20040902 |
| Estrogen receptor-positive human epithelial ovarian carcinoma cells respond to the antitumor drug suramin with increased proliferation: possible insight into ER and epidermal growth factor signaling interactions in ovarian cancer. | Gynecologic oncology 20040901 |
| Sleeping sickness in brothers in london. | The Pediatric infectious disease journal 20040901 |
| Suramin sensitizing cells to ionizing radiation by inactivating DNA-dependent protein kinase. | Radiation research 20040901 |
| The N-terminal Ca2+-independent calmodulin-binding site on the inositol 1,4,5-trisphosphate receptor is responsible for calmodulin inhibition, even though this inhibition requires Ca2+. | Molecular pharmacology 20040801 |
| Uridine 5'-triphosphate stimulates alveolar fluid clearance in the isolated rat lungs. | Journal of pharmacological sciences 20040801 |
| Induction of apoptosis in bone marrow cells is mediated via purinergic receptors. | Bulletin of experimental biology and medicine 20040801 |
| Oscillatory calcium responses mediated by P2Y2 purinergic receptors in terminal Schwann cells of longitudinal lanceolate endings isolated from rat vibrissae. | The Journal of comparative neurology 20040726 |
| The heparan sulfate-specific epitope 10E4 is NO-sensitive and partly inaccessible in glypican-1. | Glycobiology 20040701 |
| Purinergic receptors coupled to intracellular Ca2+ signals and exocytosis in rat prostate neuroendocrine cells. | The Journal of biological chemistry 20040625 |
| Misfolding of the prion protein at the plasma membrane induces endocytosis, intracellular retention and degradation. | Traffic (Copenhagen, Denmark) 20040601 |
| Suramin inhibits death receptor-induced apoptosis in vitro and fulminant apoptotic liver damage in mice. | Nature medicine 20040601 |
| Biochemical characterization and crystallization of recombinant 3-phosphoglycerate kinase of Plasmodium falciparum. | Biochimica et biophysica acta 20040601 |
| Cheating death in the liver. | Nature medicine 20040601 |
| Expression of P2Y2 purinoceptors in MCG 101 murine sarcoma cells, and HT-29 human colon carcinoma cells. | Autonomic neuroscience : basic & clinical 20040531 |
| Cadmium inhibits GABA-activated ion currents by increasing intracellular calcium level in snail neurons. | Brain research 20040522 |
| P2Y purinergic receptor regulation of CFTR chloride channels in mouse cardiac myocytes. | The Journal of physiology 20040501 |
| Resistance to drug by different isolates Trypanosoma evansi in China. | Acta tropica 20040501 |
| Functional regulation of the cardiac ryanodine receptor by suramin and calmodulin involves multiple binding sites. | Molecular pharmacology 20040501 |
| Suramin derivatives as inhibitors and activators of protein-tyrosine phosphatases. | The Journal of biological chemistry 20040409 |
| Adhesion or plasmin regulates tyrosine phosphorylation of a novel membrane glycoprotein p80/gp140/CUB domain-containing protein 1 in epithelia. | The Journal of biological chemistry 20040409 |
| Bloodstream form-specific up-regulation of silent vsg expression sites and procyclin in Trypanosoma brucei after inhibition of DNA synthesis or DNA damage. | The Journal of biological chemistry 20040402 |
| Structure-activity relationships of analogues of NF449 confirm NF449 as the most potent and selective known P2X1 receptor antagonist. | European journal of medicinal chemistry 20040401 |
| Role of adenylate and guanylate cyclases in beta1-, beta2-, and beta3-adrenoceptor-mediated relaxation of internal anal sphincter smooth muscle. | The Journal of pharmacology and experimental therapeutics 20040301 |
| Synthesis of nitric oxide in postganglionic myenteric neurons during endotoxemia: implications for gastric motor function in rats. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040301 |
| [3H]alpha,beta-methylene ATP binding to P2X purinoceptor is unaffected by volatile anaesthetics. | European journal of anaesthesiology 20040301 |
| Desensitization masks nanomolar potency of ATP for the P2X1 receptor. | The Journal of biological chemistry 20040220 |
| Stimulation of extracellular signal-regulated kinase pathway by suramin with concomitant activation of DNA synthesis in cultured cells. | The Journal of pharmacology and experimental therapeutics 20040201 |
| Suramin inhibits spinal cord microglia activation and long-term hyperalgesia induced by formalin injection. | The journal of pain : official journal of the American Pain Society 20040201 |
| Discrete but simultaneous release of adenine nucleotides and serotonin from mouse megakaryocytes as detected with patch- and carbon-fiber electrodes. | American journal of physiology. Cell physiology 20040101 |
| ATP-induced ATP release from astrocytes. | Journal of neurochemistry 20040101 |
| A Phase II trial of suramin monthly x 3 for hormone-refractory prostate carcinoma. | Cancer 20040101 |
| Novel mechanism of enhanced nociception in a model of AIDS therapy-induced painful peripheral neuropathy in the rat. | Pain 20040101 |
| Megazol combined with suramin improves a new diagnosis index of the early meningo-encephalitic phase of experimental African trypanosomiasis. | Tropical medicine & international health : TM & IH 20040101 |
| Suramin and radiotherapy in newly diagnosed glioblastoma: phase 2 NABTT CNS Consortium study. | Neuro-oncology 20040101 |
| [Effect of suramin on proliferation and migration of lens epithelial cells in vitro]. | Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20040101 |
| Suramin has adjuvant properties and promotes expansion of antigen-specific Th1 and Th2 cells in vivo. | International immunopharmacology 20040101 |
| Diquafosol elicits increases in net Cl- transport through P2Y2 receptor stimulation in rabbit conjunctiva. | Ophthalmic research 20040101 |
| RNA-interference silencing of the adenosine transporter-1 gene in Trypanosoma evansi confers resistance to diminazene aceturate. | Experimental parasitology 20040101 |
| Biopolymer-mediated suramin chemotherapy in the treatment of experimental brain tumours. | Acta oncologica (Stockholm, Sweden) 20040101 |
| Cooperation in signal transduction of extracellular guanosine 5' triphosphate and nerve growth factor in neuronal differentiation of PC12 cells. | Neuroscience 20040101 |
| [Regulation of the adenylate cyclase signaling system in cultured Dileptus anser and Tetrahymena pyriformis by insulin peptide superfamily]. | Zhurnal evoliutsionnoi biokhimii i fiziologii 20040101 |
| Peritonitis-induced antitumor activity of peritoneal macrophages from uremic patients. | Folia histochemica et cytobiologica 20040101 |
| Dissecting individual current components of co-expressed human P2X1 and P2X7 receptors. | Current topics in medicinal chemistry 20040101 |
| Physiological role for P2X1 receptors in renal microvascular autoregulatory behavior. | The Journal of clinical investigation 20031215 |
| Exacerbation of TGF-beta-induced cataract by FGF-2 in cultured rat lenses. | Molecular vision 20031215 |
| Antiallodynic effects of intrathecal orexins in a rat model of postoperative pain. | The Journal of pharmacology and experimental therapeutics 20031201 |
| Extended pharmacological profiles of rat P2Y2 and rat P2Y4 receptors and their sensitivity to extracellular H+ and Zn2+ ions. | British journal of pharmacology 20031201 |
| ATP and UTP responses of cultured rat aortic smooth muscle cells revisited: dominance of P2Y2 receptors. | British journal of pharmacology 20031201 |
| Suramin inhibits the growth of malignant mesothelioma in vitro, and in vivo, in murine flank and intraperitoneal models. | Lung cancer (Amsterdam, Netherlands) 20031201 |
| [Progress in researches on drugs for prostate cancer]. | Zhonghua nan ke xue = National journal of andrology 20031201 |
| The HIV-1 Tat transactivator protein: a therapeutic target? | IUBMB life 20031201 |
| Suramin and suramin analogues inhibit merozoite surface protein-1 secondary processing and erythrocyte invasion by the malaria parasite Plasmodium falciparum. | The Journal of biological chemistry 20031128 |
| ATP modulates intracellular Ca2+ and firing rate through a P2Y1 purinoceptor in cane toad pacemaker cells. | The Journal of physiology 20031101 |
| Functional evidence that ATP or a related purine is an inhibitory NANC neurotransmitter in the mouse jejunum: study on the identity of P2X and P2Y purinoceptors involved. | British journal of pharmacology 20031101 |
| P2X receptor-mediated excitatory synaptic currents in somatosensory cortex. | Molecular and cellular neurosciences 20031101 |
| Aminophospholipids have no access to the luminal side of the biliary canaliculus: implications for thr specific lipid composition of the bile fluid. | The Journal of biological chemistry 20031017 |
| ATP causes glomus cell [Ca2+]c increase without corresponding increases in CSN activity. | Respiratory physiology & neurobiology 20031016 |
| High density lipoprotein-associated lysosphingolipids reduce E-selectin expression in human endothelial cells. | Biochemical and biophysical research communications 20031010 |
| Role of phospholipase D in agonist-stimulated lysophosphatidic acid synthesis by ovarian cancer cells. | Journal of lipid research 20031001 |
| Ecto-ATPase activity on the surface of Trypanosoma cruzi and its possible role in the parasite-host cell interaction. | Parasitology research 20031001 |
| Magnesium-dependent ecto-ATP diphosphohydrolase activity in Herpetomonas muscarum muscarum. | Current microbiology 20031001 |
| Antagonism of myotoxic and paralyzing activities of bothropstoxin-I by suramin. | Toxicon : official journal of the International Society on Toxinology 20030915 |
| Early glial cell reactivity in experimental retinal detachment: effect of suramin. | Investigative ophthalmology & visual science 20030901 |
| Guillain-Barré syndrome after simultaneous therapy with suramin and interferon-alpha. | European journal of neurology 20030901 |
| Wax moth, Galleria mellonella fat body receptor for high-density lipophorin (HDLp). | Archives of insect biochemistry and physiology 20030901 |
| Polydeoxyribonucleotide (PDRN) promotes human osteoblast proliferation: a new proposal for bone tissue repair. | Life sciences 20030829 |
| Autocrine growth factor regulation of lysyl oxidase expression in transformed fibroblasts. | The Journal of biological chemistry 20030815 |
| Phase I study of low-dose suramin as a chemosensitizer in patients with advanced non-small cell lung cancer. | Clinical cancer research : an official journal of the American Association for Cancer Research 20030815 |
| Antifibrotic effects of suramin in injured skeletal muscle after laceration. | Journal of applied physiology (Bethesda, Md. : 1985) 20030801 |
| P2Y(2) receptor elicits PAS-positive glycoprotein secretion from rabbit conjunctival goblet cells in vivo. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20030801 |
| [Influence of suramin on the proliferation of prostatic carcinoma cells PC-3M]. | Zhonghua nan ke xue = National journal of andrology 20030801 |
| Differential properties of astrocyte calcium waves mediated by P2Y1 and P2Y2 receptors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030730 |
| Intercellular calcium waves mediate preferential cell growth toward the wound edge in polarized hepatic cells. | Experimental cell research 20030715 |
| Characterisation of an uridine-specific binding site in rat cerebrocortical homogenates. | Neurochemistry international 20030701 |
| Conducted dilations initiated by purines in arterioles are endothelium dependent and require endothelial Ca2+. | American journal of physiology. Heart and circulatory physiology 20030701 |
| Suramin suppresses growth, alkaline-phosphatase and telomerase activity of human osteosarcoma cells in vitro. | The international journal of biochemistry & cell biology 20030701 |
| Effects of intravenous and infravesical administration of suramin, terazosin and BMY 7378 on bladder instability in conscious rats with bladder outlet obstruction. | BJU international 20030701 |
| Effect of halothane on the guanosine 5' triphosphate binding activity of G-protein alphai subunits. | Anesthesiology 20030701 |
| 1,4-Dihydroxy-2,3-dioxatricyclo[8.4.0.0(4,9)]tetradecane and derivatives with in vitro activity against Plasmodium falciparum, Trypanasoma b brucei, Trypanasoma cruzi, and Leishmaniasis infantum. | Bioorganic & medicinal chemistry letters 20030616 |
| Kinetics of inhibition of sperm beta-acrosin activity by suramin. | FEBS letters 20030605 |
| Third-generation beta-blockers stimulate nitric oxide release from endothelial cells through ATP efflux: a novel mechanism for antihypertensive action. | Circulation 20030603 |
| Effects of varying impulse number on cotransmitter contributions to sympathetic vasoconstriction in rat tail artery. | American journal of physiology. Heart and circulatory physiology 20030601 |
| Current chemotherapy of human African trypanosomiasis. | Parasitology research 20030601 |
| S1P3 receptors mediate the potent constriction of cerebral arteries by sphingosine-1-phosphate. | European journal of pharmacology 20030523 |
| Suramin inhibits beta-bungarotoxin-induced activation of N-methyl-D-aspartate receptors and cytotoxicity in primary neurons. | Toxicology and applied pharmacology 20030515 |
| P2Y receptor specific for diadenosine tetraphosphate in lung: selective inhibition by suramin, PPADS, Ip5I, and not by MRS-2197. | European journal of pharmacology 20030502 |
| A chicken model to study the embryology of cloacal exstrophy. | Journal of pediatric surgery 20030501 |
| Nitrergic prejunctional inhibition of purinergic neuromuscular transmission in the hamster proximal colon. | Journal of neurophysiology 20030501 |
| Arsenicals (melarsoprol), pentamidine and suramin in the treatment of human African trypanosomiasis. | Parasitology research 20030501 |
| Functional barrier principle for growth-factor-based articular cartilage repair. | Osteoarthritis and cartilage 20030501 |
| ATP modulation of sodium currents in rat dorsal root ganglion neurons. | Brain research 20030404 |
| P2 purinoceptors regulate calcium-activated chloride and fluid transport in 31EG4 mammary epithelia. | American journal of physiology. Cell physiology 20030401 |
| Mechanical stretch-induced apoptosis in smooth muscle cells is mediated by beta1-integrin signaling pathways. | Hypertension (Dallas, Tex. : 1979) 20030401 |
| Lipophorin interaction with the midgut of Rhodnius prolixus: characterization and changes in binding capacity. | Insect biochemistry and molecular biology 20030401 |
| Interaction of the D2short dopamine receptor with G proteins: analysis of receptor/G protein selectivity. | Biochemical pharmacology 20030401 |
| ATP released from astrocytes during swelling activates chloride channels. | Journal of neurophysiology 20030401 |
| Adenosine 5'-triphosphate (ATP) is an excitatory cotransmitter with noradrenaline to the smooth muscle of the rat prostate gland. | British journal of pharmacology 20030401 |
| A model for left juxtaposition of the atrial appendages in the chick. | Cardiology in the young 20030401 |
| Inhibition of heparanase activity and heparanase-induced angiogenesis by suramin analogues. | International journal of cancer 20030320 |
| ATP-induced, sustained calcium signalling in cultured rat cortical astrocytes: evidence for a non-capacitative, P2X7-like-mediated calcium entry. | FEBS letters 20030313 |
| ATP-induced calcium oscillations and change of P2Y subtypes with culture conditions in HeLa cells. | Cell biochemistry and function 20030301 |
| Regulation of the calcium release channel from skeletal muscle by suramin and the disulfonated stilbene derivatives DIDS, DBDS, and DNDS. | Biophysical journal 20030301 |
| A novel early chorioallantoic membrane assay demonstrates quantitative and qualitative changes caused by antiangiogenic substances. | The Journal of laboratory and clinical medicine 20030301 |
| Mechanisms involved in the loss of excitatory post-stimulus responses by inflammation. | Naunyn-Schmiedeberg's archives of pharmacology 20030301 |
| Investigation of postjunctional alpha1- and alpha2-adrenoceptor subtypes in vas deferens from wild-type and alpha(2A/D)-adrenoceptor knockout mice. | British journal of pharmacology 20030301 |
| IGF-1 receptor mediates differentiation of primary cultures of mouse skeletal myoblasts. | Molecular and cellular endocrinology 20030227 |
| Activation of deoxycytidine kinase by UV-C-irradiation in chronic lymphocytic leukemia B-lymphocytes. | Biochemical pharmacology 20030215 |
| P2Y-receptor regulates size of endothelial cells in an intracellular Ca2+ dependent manner. | Life sciences 20030214 |
| Nitric oxide inhibits adenosine 5'-triphosphate-induced Ca2+ response in inner hair cells of the guinea pig cochlea. | Neuroscience letters 20030213 |
| Multiple signalling pathways mediate fungal elicitor-induced beta-thujaplicin biosynthesis in Cupressus lusitanica cell cultures. | Journal of experimental botany 20030201 |
| Blockade of sulfur mustard cytotoxicity in human epidermal keratinocytes with the purinergic receptor antagonist suramin. | Veterinary and human toxicology 20030201 |
| Teratogenic effects of suramin on the chick embryo. | Anatomy and embryology 20030201 |
| Neurotransmitters involved in the fast inhibitory junction potentials in mouse distal colon. | European journal of pharmacology 20030124 |
| Cloning, tissue distribution and functional characterization of the chicken P2X1 receptor. | FEBS letters 20030102 |
| A phase I study of intravesical suramin for the treatment of superficial transitional cell carcinoma of the bladder. | The Journal of urology 20030101 |
| Presence of diadenosine polyphosphates in the aqueous humor: their effect on intraocular pressure. | The Journal of pharmacology and experimental therapeutics 20030101 |
| Role of chemotherapy in hormone-refractory prostate cancer. Old issues, recent advances and new perspectives. | Urologia internationalis 20030101 |
| Modulation of myocardial contractility by lysophosphatidic acid (LPA). | Journal of molecular and cellular cardiology 20030101 |
| CD45 protein-tyrosine phosphatase inhibitor development. | Current topics in medicinal chemistry 20030101 |
| Suramin modulates wound healing of rabbit conjunctiva after trabeculectomy: comparison with mitomycin C. | Current eye research 20030101 |
| Suramin selectively inhibits carcinoma cell growth that is dependent on extracellular polyamines. | Anticancer research 20030101 |
| Alzheimer's amyloid beta-peptide enhances ATP/gap junction-mediated calcium-wave propagation in astrocytes. | Neuromolecular medicine 20030101 |
| [Comparative effects of complement inhibitors in vitro and in vivo experiments: an immunoenzyme method in studying subcomponent C1q inhibition and complement inhibition in model animals]. | Biomeditsinskaia khimiia 20030101 |
| Suramin inhibits the in vitro expression of encephalitis B virus proteins NS3 and E. | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20030101 |
| [The return of sleeping sickness in an epidemic form: international action for drugs]. | Nederlands tijdschrift voor geneeskunde 20021228 |
| Suramin interacts with the calmodulin binding site on the ryanodine receptor, RYR1. | The Journal of biological chemistry 20021220 |
| Calcium rise in cultured neurons from medial septum elicits calcium waves in surrounding glial cells. | Brain research 20021213 |
| Human African trypanosomiasis: potential therapeutic benefits of an alternative suramin and melarsoprol regimen. | Parasitology international 20021201 |
| Suramin reduces infarct volume in a model of focal brain ischemia in rats. | Experimental brain research 20021201 |
| Role of G protein and protein kinase signalling in influenza virus budding in MDCK cells. | The Journal of general virology 20021201 |
| Nitric oxide-dependent processing of heparan sulfate in recycling S-nitrosylated glypican-1 takes place in caveolin-1-containing endosomes. | The Journal of biological chemistry 20021115 |
| Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors. | Cellular signalling 20021101 |
| Human Ntera-2/D1 neuronal progenitor cells endogenously express a functional P2Y1 receptor. | Neuropharmacology 20021101 |
| P2X purinergic receptor antagonist accelerates skin barrier repair and prevents epidermal hyperplasia induced by skin barrier disruption. | The Journal of investigative dermatology 20021101 |
| Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists. | Biochemical pharmacology 20021015 |
| Application of kinetic-based biospecific affinity chromatographic systems to ATP-dependent enzymes: studies with yeast hexokinase. | Analytical biochemistry 20021015 |
| Ectonucleotide diphosphohydrolase activity in Crithidia deanei. | Parasitology research 20021001 |
| Regulation of the avidity of ternary complexes containing the human 5-HT(1A) receptor by mutation of a receptor contact site on the interacting G protein alpha subunit. | British journal of pharmacology 20021001 |
| Recent advances in drug-induced neuropathies. | Current opinion in neurology 20021001 |
| IL-1 beta potentiates heat-activated currents in rat sensory neurons: involvement of IL-1RI, tyrosine kinase, and protein kinase C. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021001 |
| Essential role of growth factor receptor-mediated signal transduction through the mitogen-activated protein kinase pathway in early embryogenesis of the echinoderm. | Development, growth & differentiation 20021001 |
| Evoked and spontaneous purinergic junctional Ca2+ transients (jCaTs) in rat small arteries. | Circulation research 20020920 |
| Sensory afferent selective role of P2 receptors in the nucleus tractus solitarii for mediating the cardiac component of the peripheral chemoreceptor reflex in rats. | The Journal of physiology 20020915 |
| Effects of luminal flow and nucleotides on [Ca(2+)](i) in rabbit cortical collecting duct. | American journal of physiology. Renal physiology 20020901 |
| Enzyme kinetics and pharmacological characterization of nucleotidases released from the guinea pig isolated vas deferens during nerve stimulation: evidence for a soluble ecto-nucleoside triphosphate diphosphohydrolase-like ATPase and a soluble ecto-5'-nucleotidase-like AMPase. | The Journal of pharmacology and experimental therapeutics 20020901 |
| Purinergic and muscarinic modulation of the cell cycle and calcium signaling in the chick retinal ventricular zone. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20020901 |
| Characterization of cholera toxin B subunit-induced Ca(2+) influx in neuroblastoma cells: evidence for a voltage-independent GM1 ganglioside-associated Ca(2+) channel. | Journal of neuroscience research 20020901 |
| Characterization of cholesterol transport from midgut to fat body in Manduca sexta larvae. | Insect biochemistry and molecular biology 20020901 |
| Establishment of the organizing activity of the lower endodermal half of the dorsal marginal zone is a primary and necessary event for dorsal axis formation in Cynops pyrrhogaster. | The International journal of developmental biology 20020901 |
| Potentiation of inhibitory glycinergic neurotransmission by Zn2+: a synergistic interplay between presynaptic P2X2 and postsynaptic glycine receptors. | The European journal of neuroscience 20020901 |
| The DC electrical-field-induced Ca(2+) response and growth stimulation of multicellular tumor spheroids are mediated by ATP release and purinergic receptor stimulation. | Journal of cell science 20020815 |
| Randomized study of three different doses of suramin administered with a fixed dosing schedule in patients with advanced prostate cancer: results of intergroup 0159, cancer and leukemia group B 9480. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020815 |
| Ultraviolet-B activates components of the systemin signaling pathway in Lycopersicon peruvianum suspension-cultured cells. | The Journal of biological chemistry 20020809 |
| GLUT4-containing vesicles are released from membranes by phospholipase D cleavage of a GPI anchor. | American journal of physiology. Endocrinology and metabolism 20020801 |
| Role of luminal ATP in regulating electrogenic Na(+) absorption in guinea pig distal colon. | American journal of physiology. Gastrointestinal and liver physiology 20020801 |
| ATP induces leukemia inhibitory factor mRNA in cultured rat astrocytes. | Journal of neuroimmunology 20020801 |
| Blastopore formation and dorsal mesoderm induction are independent events in early Cynops embryogenesis. | Development, growth & differentiation 20020801 |
| Evidence for a non-LDL-mediated entry route for the trypanocidal drug suramin in Trypanosoma brucei. | Molecular and biochemical parasitology 20020701 |
| A phase I study of suramin with once- or twice-monthly dosing in patients with advanced cancer. | Cancer chemotherapy and pharmacology 20020701 |
| Suramin-induced reversal of chronic cerebral vasospasm in experimental subarachnoid hemorrhage. | Journal of neurosurgery 20020701 |
| Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 20-2002. A 37-year-old man with fever, hepatosplenomegaly, and a cutaneous foot lesion after a trip to Africa. | The New England journal of medicine 20020627 |
| ATP as a putative sensory mediator: activation of intrinsic sensory neurons of the myenteric plexus via P2X receptors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20020615 |
| Sphingosine 1-phosphate induces Ca2+ transients and cytoskeletal rearrangement in C2C12 myoblastic cells. | American journal of physiology. Cell physiology 20020601 |
| P2X purinergic receptor channel expression and function in bovine aortic endothelium. | American journal of physiology. Heart and circulatory physiology 20020601 |
| Effect of suramin on myotoxicity of some crotalid snake venoms. | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20020601 |
| Extracellular ATP and UTP activate the protein kinase B/Akt cascade via the P2Y(2) purinoceptor in renal mesangial cells. | British journal of pharmacology 20020601 |
| [Effect of activation and blockade of central P2X receptors on body temperature]. | Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20020601 |
| Adenosine 5'-triphosphate-evoked calcium responses in terminal Schwann cells of lanceolate sensory endings isolated from rat vibrissae. | Neuroscience letters 20020517 |
| Mg(2+)-sensitive non-capacitative basolateral Ca(2+) entry secondary to cell swelling in the polarized renal A6 epithelium. | The Journal of physiology 20020515 |
| Activation of ATP receptor increases the cytosolic Ca(2+) concentration in ventral tegmental area neurons of rat brain. | Brain research 20020510 |
| Nonselective cation conductance activated by muscarinic and purinergic receptors in rat spiral ganglion neurons. | American journal of physiology. Cell physiology 20020501 |
| Complementary role of extracellular ATP and adenosine in ischemic preconditioning in the rat heart. | American journal of physiology. Heart and circulatory physiology 20020501 |
| Enhanced IPC by activation of pertussis toxin-sensitive and -insensitive G protein-coupled purinoceptors. | American journal of physiology. Heart and circulatory physiology 20020501 |
| Modulation of phrenic motoneuron excitability by ATP: consequences for respiratory-related output in vitro. | Journal of applied physiology (Bethesda, Md. : 1985) 20020501 |
| Purinergic receptor signaling at the basolateral membrane of macula densa cells. | Journal of the American Society of Nephrology : JASN 20020501 |
| Suramin's development: what did we learn? | Investigational new drugs 20020501 |
| Phosphorothioate oligonucleotides, suramin and heparin inhibit DNA-dependent protein kinase activity. | British journal of cancer 20020408 |
| Nucleotide receptors involved in UTP-induced rat arterial smooth muscle cell migration. | Circulation research 20020405 |
| Regional specification of the head and trunk-tail organizers of a urodele (Cynops pyrrhogaster) embryo is patterned during gastrulation. | Developmental biology 20020401 |
| Suppression of myocardial inflammation using suramin, a growth factor blocker. | Circulation journal : official journal of the Japanese Circulation Society 20020401 |
| Involvement of purinergic signalling in central mechanisms of body temperature regulation in rats. | British journal of pharmacology 20020401 |
| Characteristics of ATP-induced current through P2X7 receptor in NG108-15 cells: unique antagonist sensitivity and lack of pore formation. | Japanese journal of pharmacology 20020401 |
| Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase. | The Journal of biological chemistry 20020322 |
| P2Y11 receptors activate adenylyl cyclase and contribute to nucleotide-promoted cAMP formation in MDCK-D(1) cells. A mechanism for nucleotide-mediated autocrine-paracrine regulation. | The Journal of biological chemistry 20020308 |
| Adenosine 5'-triphosphate inhibits slow depolarization induced by repetitive dorsal root stimulation via P2Y purinoceptors in substantia gelatinosa neurons of the adult rat spinal cord slices with the dorsal root attached. | Neuroscience letters 20020308 |
| Effects of extracellular ATP on freshly isolated mouse skeletal muscle cells during pre-natal and post-natal development. | Pflugers Archiv : European journal of physiology 20020301 |
| Kinetics of antagonist actions at rat P2X2/3 heteromeric receptors. | British journal of pharmacology 20020301 |
| Capillary electrophoresis investigation of a partially unfolded conformation of beta(2)-microglobulin. | Electrophoresis 20020301 |
| TNP-ATP, a potent P2X3 receptor antagonist, blocks acetic acid-induced abdominal constriction in mice: comparison with reference analgesics. | Pain 20020301 |
| Capillary plexus development in the day five to day six chick chorioallantoic membrane is inhibited by cytochalasin D and suramin. | The Journal of experimental zoology 20020215 |
| Suramin affects coupling of rhodopsin to transducin. | Biophysical journal 20020201 |
| [African trypanosomiasis--a rare imported disease]. | Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20020110 |
| Characterization of an ecto-ATPase of Tritrichomonas foetus. | Veterinary parasitology 20020103 |
| Interactions between zona pellucida glycoproteins and sperm proacrosin/acrosin during fertilization. | Journal of reproductive immunology 20020101 |
| Regulation of transcervical permeability by two distinct P2 purinergic receptor mechanisms. | American journal of physiology. Cell physiology 20020101 |
| African trypanosomiasis in travelers returning to the United Kingdom. | Emerging infectious diseases 20020101 |
| Development of Gs-selective inhibitory compounds. | Methods in enzymology 20020101 |
| Early growth response-1 gene (Egr-1) promoter induction by ionizing radiation in U87 malignant glioma cells in vitro. | European journal of biochemistry 20020101 |
| Controversies in chemotherapy of prostate cancer. | Frontiers of radiation therapy and oncology 20020101 |
| Cholinergic and purinergic contribution to the micturition reflex in conscious rats with long-term bladder outlet obstruction. | Neurourology and urodynamics 20020101 |
| Biased inhibition by a suramin analogue of A1-adenosine receptor/G protein coupling in fused receptor/G protein tandems: the A1-adenosine receptor is predominantly coupled to Goalpha in human brain. | Naunyn-Schmiedeberg's archives of pharmacology 20020101 |
| Chemotherapy-induced peripheral neuropathy. | Journal of neurology 20020101 |
| Suramin affects capsaicin responses and capsaicin-noxious heat interactions in rat dorsal root ganglia neurones. | Physiological research 20020101 |
| Structure-activity relationships of suramin and pyridoxal-5'-phosphate derivatives as P2 receptor antagonists. | Current pharmaceutical design 20020101 |
| The low density lipoprotein receptor-related protein contributes to selective uptake of high density lipoprotein cholesteryl esters by SW872 liposarcoma cells and primary human adipocytes. | The Journal of biological chemistry 20011228 |
| Suramin inhibits respiration and induces membrane permeability transition in isolated rat liver mitochondria. | Toxicology 20011201 |
| Extracellular nucleotides regulate cellular functions of podocytes in culture. | American journal of physiology. Renal physiology 20011201 |
| Roles of norepinephrine and ATP in sympathetically evoked vasoconstriction in rat tail and hindlimb in vivo. | American journal of physiology. Heart and circulatory physiology 20011201 |
| P2X2 receptor mediates stimulation of parasensory cation absorption by cochlear outer sulcus cells and vestibular transitional cells. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20011201 |
| FGF signaling is essential for the early events in the development of the chick nervous system and mesoderm. | The International journal of developmental biology 20011201 |
| Chloride dependent intracellular pH effects of external ATP in cultured human non-pigmented ciliary body epithelium. | Current eye research 20011201 |
| Suramin-induced neuropathy in an animal model. | Journal of the neurological sciences 20011115 |
| Nontoxic doses of suramin enhance activity of doxorubicin in prostate tumors. | The Journal of pharmacology and experimental therapeutics 20011101 |
| Availability and affordability of treatment for Human African Trypanosomiasis. | Tropical medicine & international health : TM & IH 20011101 |
| Interactions between mouse ZP2 glycoprotein and proacrosin; a mechanism for secondary binding of sperm to the zona pellucida during fertilization. | Journal of cell science 20011101 |
| Fixed higher dose schedule of suramin plus hydrocortisone in patients with hormone refractory prostate carcinoma a multicenter Phase II study. | Cancer 20011101 |
| Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia. | American journal of physiology. Gastrointestinal and liver physiology 20011001 |
| Sodium stibogluconate is a potent inhibitor of protein tyrosine phosphatases and augments cytokine responses in hemopoietic cell lines. | Journal of immunology (Baltimore, Md. : 1950) 20010915 |
| Dehydroepiandrosterone sulfate (DHEAS) suppresses P2X purinoceptor-coupled responses in PC12 cells. | Neurochemistry international 20010901 |
| Role of phosphoinositide 3OH-kinase in autocrine transformation by PDGF-BB. | Journal of cellular physiology 20010901 |
| Dynamic and stable pools of apoE differ functionally at the HepG2 cell surface. | Journal of lipid research 20010901 |
| NF449: a subnanomolar potency antagonist at recombinant rat P2X1 receptors. | Naunyn-Schmiedeberg's archives of pharmacology 20010901 |
| Ca2+ signaling regulated by an ATP-dependent autocrine mechanism in astrocytes. | Neuroreport 20010828 |
| Nontoxic doses of suramin enhance activity of paclitaxel against lung metastases. | Cancer research 20010815 |
| Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion disease. | The EMBO journal 20010801 |
| Methionine aminopeptidase-2 regulates human mesothelioma cell survival: role of Bcl-2 expression and telomerase activity. | The American journal of pathology 20010801 |
| ATP induces Ca(2+) signaling in human chondrons cultured in three-dimensional agarose films. | Osteoarthritis and cartilage 20010801 |
| Extracellular ATP activates a P2 receptor in necturus erythrocytes during hypotonic swelling. | The Journal of membrane biology 20010801 |
| Treatment of hormone refractory prostate cancer. | Seminars in urologic oncology 20010801 |
| Effect of in vivo and in vitro ethanol on adrenergic and purinergic responses of the bisected rat vas deferens to low and high frequency pulses. | Journal of autonomic pharmacology 20010801 |
| Cdc25A phosphatase suppresses apoptosis induced by serum deprivation. | Oncogene 20010727 |
| HGF/SF induces mesothelial cell migration and proliferation by autocrine and paracrine pathways. | Experimental cell research 20010715 |
| Apical P2Y4 purinergic receptor controls K+ secretion by vestibular dark cell epithelium. | American journal of physiology. Cell physiology 20010701 |
| Neural regulation of in vitro giant contractions in the rat colon. | American journal of physiology. Gastrointestinal and liver physiology 20010701 |
| A Mg-dependent ecto-ATPase in Leishmania amazonensis and its possible role in adenosine acquisition and virulence. | Archives of biochemistry and biophysics 20010701 |
| Toxicity, efficacy, and pharmacology of suramin in adults with recurrent high-grade gliomas. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010701 |
| Protein binding alters the activity of suramin, carboxyamidotriazole, and UCN-01 in an ex vivo rat aortic ring angiogenesis assay. | Clinical cancer research : an official journal of the American Association for Cancer Research 20010701 |
| Nucleotide-evoked relaxation of rat vas deferens--a possible role for endogenous ATP released upon alpha(1)-adrenoceptor stimulation. | European journal of pharmacology 20010622 |
| Extracellular nucleotides differentially regulate interleukin-1beta signaling in primary human astrocytes: implications for inflammatory gene expression. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20010615 |
| Prognostic significance of reverse transcriptase polymerase chain reaction for prostate-specific antigen in men with hormone-refractory prostate cancer. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010615 |
| Synapse-glia interactions at the mammalian neuromuscular junction. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20010601 |
| Endothelium-dependent relaxation induced by cathepsin G in porcine pulmonary arteries. | British journal of pharmacology 20010601 |
| Inhibition of insulin-like growth factor I receptor increases the antitumor activity of doxorubicin and vincristine against Ewing's sarcoma cells. | Clinical cancer research : an official journal of the American Association for Cancer Research 20010601 |
| ATP but not adenosine inhibits nonquantal acetylcholine release at the mouse neuromuscular junction. | The European journal of neuroscience 20010601 |
| Neural retina of chick embryo in organ culture: effects of blockade of growth factors by suramin. | Cell and tissue research 20010601 |
| Aldosterone upregulates purinergic responses in larval amphibian skin epithelium. | Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20010601 |
| Evidence against inhibition of sarcoplasmic reticulum Ca2+-pump as mechanism of H2O2-induced contraction of rat aorta. | Acta pharmacologica Sinica 20010601 |
| [Activation of p38 and c-Jun NH2-terminal kinase mitogen-activated protein kinases in human prostate carcinoma cell lines with different metastatic potentials]. | Zhonghua bing li xue za zhi = Chinese journal of pathology 20010601 |
| EGR-1, a UV-inducible gene in p53(-/-) mouse cells. | Experimental cell research 20010515 |
| Suramin and the suramin analogue NF307 discriminate among calmodulin-binding sites. | The Biochemical journal 20010501 |
| Transporters in African trypanosomes: role in drug action and resistance. | International journal for parasitology 20010501 |
| Effect on urinary bladder function and arterial blood pressure of the activation of putative purine receptors in brainstem areas. | Autonomic neuroscience : basic & clinical 20010412 |
| Purinergic regulation of intracellular Ca2+ concentration of rat pituitary folliculo-stellate cells in primary culture. | Journal of neuroendocrinology 20010401 |
| Direct autocrine inhibition and cAMP-dependent potentiation of single L-type Ca2+ channels in bovine chromaffin cells. | The Journal of physiology 20010401 |
| Phase 1 drug interaction study of suramin and warfarin in patients with prostate cancer. | American journal of clinical oncology 20010401 |
| Promotion of formation of amyloid fibrils by aluminium adenosine triphosphate (AlATP). | Journal of inorganic biochemistry 20010401 |
| Nicorandil--induced ATP release in endothelial cells of rat caudal artery is associated with increase in intracellular Ca(2+). | European journal of pharmacology 20010330 |
| Molecular cloning and characterization of the mouse P2Y4 nucleotide receptor. | European journal of pharmacology 20010330 |
| Vascular endothelial growth factor and basic fibroblast growth factor urine levels as predictors of outcome in hormone-refractory prostate cancer patients: a cancer and leukemia group B study. | Cancer research 20010315 |
| Short- and long-term functional alterations of the skeletal muscle calcium release channel (Ryanodine receptor) by Suramin: apparent dissociation of single channel current recording and [3H]ryanodine binding. | Molecular pharmacology 20010301 |
| Serum prostate-specific antigen decline as a marker of clinical outcome in hormone-refractory prostate cancer patients: association with progression-free survival, pain end points, and survival. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010301 |
| Ectoenzymatic breakdown of diadenosine polyphosphates by Xenopus laevis oocytes. | European journal of biochemistry 20010301 |
| Metabolic studies of glycosphingolipid accumulation in mucopolysaccharidosis IIID. | Molecular genetics and metabolism 20010301 |
| Pharmacological characterisation of pyrimidinoceptor responses in NG108-15 cells. | European journal of pharmacology 20010301 |
| Regulation of chicken gizzard ecto-ATPase activity by modulators that affect its oligomerization status. | Archives of biochemistry and biophysics 20010301 |
| Vascular smooth muscle cell proliferation is effectively suppressed by the non-specific growth factor inhibitor suramin. | Japanese heart journal 20010301 |
| General aspects of anti-angiogenesis and cancer therapy. | Expert opinion on biological therapy 20010301 |
| G(i)-mediated Cas tyrosine phosphorylation in vascular endothelial cells stimulated with sphingosine 1-phosphate: possible involvement in cell motility enhancement in cooperation with Rho-mediated pathways. | The Journal of biological chemistry 20010216 |
| N-unsubstituted glucosamine in heparan sulfate of recycling glypican-1 from suramin-treated and nitrite-deprived endothelial cells. mapping of nitric oxide/nitrite-susceptible glucosamine residues to clustered sites near the core protein. | The Journal of biological chemistry 20010209 |
| Suramin prevents cerebellar granule cell-death induced by dequalinium. | Neurochemistry international 20010201 |
| Analysis of purine- and pyrimidine-induced vascular responses in the isolated rat cerebral arteriole. | American journal of physiology. Heart and circulatory physiology 20010201 |
| Mechanism of prolonged vasorelaxation to ATP in the rat isolated mesenteric arterial bed. | British journal of pharmacology 20010201 |
| The effects of P2Y receptor agonists and adenosine on prostaglandin production by the guinea-pig uterus. | British journal of pharmacology 20010201 |
| Intercellular communication upon mechanical stimulation of CPAE- endothelial cells is mediated by nucleotides. | Cell calcium 20010201 |
| Purinoceptor-mediated calcium mobilization and proliferation in HaCaT keratinocytes. | Journal of dermatological science 20010201 |
| Human bladder cancer invasion model using rat bladder in vitro and its use to test mechanisms and therapeutic inhibitors of invasion. | British journal of cancer 20010201 |
| Purine and pyrimidine nucleotide-sensitive phospholipase A(2) in ampulla from frog semicircular canal. | American journal of physiology. Regulatory, integrative and comparative physiology 20010201 |
| Peritubular fluid viscosity modulates H+ flux in proximal tubules through NO release. | American journal of physiology. Renal physiology 20010201 |
| Current status of cytotoxic chemotherapy in hormone refractory prostate cancer. | European urology 20010201 |
| Alteration of spontaneous firing rate of primary myelinated afferents by ATP in adjuvant-induced inflamed rats. | Brain research bulletin 20010115 |
| Frequency dependent alpha(2)-adrenoceptor mediated modulation of excitatory junction potentials in guinea-pig mesenteric artery. | European journal of pharmacology 20010105 |
| Potentiation of cytokine induction of group IIA phospholipase A(2) in rat mesangial cells by ATP and adenosine via the A2A adenosine receptor. | British journal of pharmacology 20010101 |
| Multiple P2X receptors on guinea-pig pelvic ganglion neurons exhibit novel pharmacological properties. | British journal of pharmacology 20010101 |
| Neural mechanisms underlying migrating motor complex formation in mouse isolated colon. | British journal of pharmacology 20010101 |
| Heterogeneous calcium responses to extracellular ATP in cultured rat renal tubule cells. | Clinica chimica acta; international journal of clinical chemistry 20010101 |
| Early elicitor-induced events in chickpea cells: functional links between oxidative burst, sequential occurrence of extracellular alkalinisation and acidification, K+/H+ exchange and defence-related gene activation. | Zeitschrift fur Naturforschung. C, Journal of biosciences 20010101 |
| Suramin to enhance glaucoma filtering procedures: a clinical comparison with mitomycin. | Ophthalmic surgery and lasers 20010101 |
| Excitatory effect of ATP on acutely dissociated ventromedial hypothalamic neurons of the rat. | Neuroscience 20010101 |
| An ex vivo angiogenesis assay utilizing commercial porcine carotid artery: modification of the rat aortic ring assay. | Angiogenesis 20010101 |
| Requirement for ERK activation in cisplatin-induced apoptosis. | The Journal of biological chemistry 20001215 |
| Tamoxifen-induced enhancement of calcium signaling in glioma and MCF-7 breast cancer cells. | Cancer research 20001001 |
| Synthesis of single- and double-chain fluorocarbon and hydrocarbon galactosyl amphiphiles and their anti-HIV-1 activity. | Carbohydrate research 20000724 |
| Pharmacological characterization of the human P2Y11 receptor. | British journal of pharmacology 19991101 |
| Allosteric control of gating and kinetics at P2X(4) receptor channels. | The Journal of neuroscience : the official journal of the Society for Neuroscience 19990901 |
| Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. | The Journal of biological chemistry 19990702 |
| Suramin analogues with a 2-phenylbenzimidazole moiety as partial structure; potential anti HIV- and angiostatic drugs, 2: Sulfanilic acid-, benzenedisulfonic acid-, and naphthalenetrisulfonic acid analogues. | Archiv der Pharmazie 19980301 |
| Calcium- and calmodulin-dependent PMA-activation of the CD44 adhesion molecule. | Cell adhesion and communication 19980101 |
| Mechanisms of inhibition of IL-6-mediated immunoglobulin secretion by dexamethasone and suramin in human lymphoid and myeloma cell lines. | Leukemia & lymphoma 19960401 |
| Dexamethasone and suramin inhibit cell proliferation and interleukin-6-mediated immunoglobulin secretion in human lymphoid and multiple myeloma cell lines. | Leukemia & lymphoma 19950501 |
| Suramin inhibits binding of the V3 region of HIV-1 envelope glycoprotein gp120 to galactosylceramide, the receptor for HIV-1 gp120 on human colon epithelial cells. | The Journal of biological chemistry 19940930 |
| Inhibitory effect of the polyanionic drug suramin on the in vitro HIV DNA integration reaction. | Archives of biochemistry and biophysics 19930901 |
| Structure-activity relationship studies with symmetric naphthalenesulfonic acid derivatives. Synthesis and influence of spacer and naphthalenesulfonic acid moiety on anti-HIV-1 activity. | Journal of medicinal chemistry 19930709 |
| Derivatives of 4-amino-3,6-disulfonato-1,8-naphthalimide inhibit reverse transcriptase and suppress human and feline immunodeficiency virus expression in cultured cells. | Journal of cellular biochemistry 19930401 |
| Selective inhibition of human cytomegalovirus replication by naphthalenedisulfonic acid derivatives. | Antiviral research 19930301 |
| Increased expression of fibroblast growth factors (FGFs) and their receptor by protamine and suramin on Kaposi's sarcoma-derived cells. | Anticancer research 19930101 |
| Effects of suramin, an anti-human immunodeficiency virus reverse transcriptase agent, on protein kinase C. Differential activation and inhibition of protein kinase C isozymes. | The Journal of biological chemistry 19900405 |
| Inhibition of human immunodeficiency virus type 1 RNase H by sulfated polyanions. | Journal of virology 19891201 |
| Efficacy of DL-alpha-difluoromethylornithine in a rat model of Pneumocystis carinii pneumonia. | Antimicrobial agents and chemotherapy 19880801 |
| Dextran sulfate suppression of viruses in the HIV family: inhibition of virion binding to CD4+ cells. | Science (New York, N.Y.) 19880429 |
| Inhibition of human immunodeficiency virus type I reverse transcriptase by suramin-related compounds. | The Journal of general virology 19870801 |
| Effect of retinoic acid on the replication of human immunodeficiency virus in HTLV-I-positive MT-4 cells. | Medical microbiology and immunology 19870101 |
| In vitro suppression of HTLV-III/LAV infectivity by a combination of acyclovir and suramin. | The Journal of infectious diseases 19861201 |
| Aurintricarboxylic acid and Evans Blue represent two different classes of anionic compounds which selectively inhibit the cytopathogenicity of human T-cell lymphotropic virus type III/lymphadenopathy-associated virus. | Biochemical and biophysical research communications 19860414 |
| Comparative inhibitory effects of suramin and other selected compounds on the infectivity and replication of human T-cell lymphotropic virus (HTLV-III)/lymphadenopathy-associated virus (LAV). | International journal of cancer 19860315 |
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