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127759-89-1 | 6H-Purin-6-one, 2-amino-9-[(1R,2R,3S)-2,3-bis(hydroxymethyl)cyclobutyl]-1,9-dihydro-
CAS No: 127759-89-1 Catalog No: AG000XDI MDL No:MFCD00870586
Product Description
Catalog Number:
AG000XDI
Chemical Name:
6H-Purin-6-one, 2-amino-9-[(1R,2R,3S)-2,3-bis(hydroxymethyl)cyclobutyl]-1,9-dihydro-
CAS Number:
127759-89-1
Molecular Formula:
C11H15N5O3
Molecular Weight:
265.2685
MDL Number:
MFCD00870586
IUPAC Name:
2-amino-9-[(1R,2R,3S)-2,3-bis(hydroxymethyl)cyclobutyl]-1H-purin-6-one
InChI:
InChI=1S/C11H15N5O3/c12-11-14-9-8(10(19)15-11)13-4-16(9)7-1-5(2-17)6(7)3-18/h4-7,17-18H,1-3H2,(H3,12,14,15,19)/t5-,6-,7-/m1/s1
InChI Key:
GWFOVSGRNGAGDL-FSDSQADBSA-N
SMILES:
OC[C@@H]1[C@@H](CO)C[C@H]1n1cnc2c1nc(N)[nH]c2=O
UNII:
8U5PYQ1R2E
Properties
Complexity:
415
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
3
Defined Bond Stereocenter Count:
0
Exact Mass:
265.117g/mol
Formal Charge:
0
Heavy Atom Count:
19
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
4
Isotope Atom Count:
0
Molecular Weight:
265.273g/mol
Monoisotopic Mass:
265.117g/mol
Rotatable Bond Count:
3
Topological Polar Surface Area:
126A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-1.9
Literature
| Title | Journal |
|---|---|
| Inactivity of the bicyclic pyrimidine nucleoside analogues against simian varicella virus (SVV) does not correlate with their substrate activity for SVV-encoded thymidine kinase. | Biochemical and biophysical research communications 20040319 |
| In vitro activity of potential anti-poxvirus agents. | Antiviral research 20030101 |
| A novel nonnucleoside inhibitor specifically targets cytomegalovirus DNA maturation via the UL89 and UL56 gene products. | Journal of virology 20011001 |
| Acyclic/carbocyclic guanosine analogues as anti-herpesvirus agents. | Nucleosides, nucleotides & nucleic acids 20010101 |
| Antiviral agents active against human herpesviruses HHV-6, HHV-7 and HHV-8. | Reviews in medical virology 20010101 |
| Antiviral efficacy of lobucavir (BMS-180194), a cyclobutyl-guanosine nucleoside analogue, in the woodchuck (Marmota monax) model of chronic hepatitis B virus (HBV) infection. | Antiviral research 20001201 |
| Ribavirin and mycophenolic acid potentiate the activity of guanine- and diaminopurine-based nucleoside analogues against hepatitis B virus. | Antiviral research 20001101 |
| In vivo anti-papillomavirus activity of nucleoside analogues including cidofovir on CRPV-induced rabbit papillomas. | Antiviral research 20001101 |
| Lamivudine, adefovir and tenofovir exhibit long-lasting anti-hepatitis B virus activity in cell culture. | Journal of viral hepatitis 20000101 |
| Guanosine analogues as anti-herpesvirus agents. | Nucleosides, nucleotides & nucleic acids 20000101 |
| Hydroxyurea potentiates the antiherpesvirus activities of purine and pyrimidine nucleoside and nucleoside phosphonate analogs. | Antimicrobial agents and chemotherapy 19991201 |
| Human cytomegalovirus: challenges, opportunities and new drug development. | Antiviral chemistry & chemotherapy 19990901 |
| Selective activity of various antiviral compounds against HHV-7 infection. | Antiviral research 19990801 |
| Susceptibility of lamivudine-resistant hepatitis B virus to other reverse transcriptase inhibitors. | The Journal of clinical investigation 19990615 |
| Identification of BMS-200475 as a potent and selective inhibitor of hepatitis B virus. | Antimicrobial agents and chemotherapy 19970701 |
| Susceptibility of human cytomegalovirus to two-drug combinations in vitro. | Antiviral therapy 19961201 |
| Analysis of phosphorylation pathways of antiherpesvirus nucleosides by varicella-zoster virus-specific enzymes. | Antimicrobial agents and chemotherapy 19960401 |
| Efficacy of BMS-180194 against experimental cytomegalovirus infections in immunocompromised mice. | Antiviral research 19960301 |
| Antiviral activity of selected acyclic nucleoside analogues against human herpesvirus 6. | Antiviral research 19951201 |
| Synthesis and antiviral activity of carbocyclic oxetanocin analogues (C-OXT-A, C-OXT-G) and related compounds. II. | Chemical & pharmaceutical bulletin 19930301 |
| Effects of purine nucleoside analogues with a cyclobutane ring and erythromycin A oxime derivatives on duck hepatitis B virus replication in vivo and in cell culture and HIV-1 in cell culture. | Journal of medical virology 19911101 |
| Antiviral activity of oxetanocins against varicella-zoster virus. | Antimicrobial agents and chemotherapy 19910701 |
| Synthesis and antiviral activity of enantiomeric forms of cyclobutyl nucleoside analogues. | Journal of medicinal chemistry 19910401 |
| Cyclobut-A and cyclobut-G: broad-spectrum antiviral agents with potential utility for the therapy of AIDS. | Journal of medicinal chemistry 19900501 |
| Cyclobut-A and cyclobut-G, carbocyclic oxetanocin analogs that inhibit the replication of human immunodeficiency virus in T cells and monocytes and macrophages in vitro. | Antimicrobial agents and chemotherapy 19900201 |
| (+-)-(1 alpha,2 beta,3 alpha)-9-[2,3-bis(hydroxymethyl)-cyclobutyl] guanine [(+-)-BHCG or SQ 33,054]: a potent and selective inhibitor of herpesviruses. | Antiviral research 19900101 |
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