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12766-00-6 | Quinazolinone
CAS No: 12766-00-6 Catalog No: AG000X9W MDL No:
Product Description
Catalog Number:
AG000X9W
Chemical Name:
Quinazolinone
CAS Number:
12766-00-6
Molecular Formula:
C8H6N2O
Molecular Weight:
146.1460
IUPAC Name:
1H-quinazolin-2-one
InChI:
InChI=1S/C8H6N2O/c11-8-9-5-6-3-1-2-4-7(6)10-8/h1-5H,(H,9,10,11)
InChI Key:
AVRPFRMDMNDIDH-UHFFFAOYSA-N
SMILES:
O=c1ncc2c([nH]1)cccc2
NSC Number:
401245
Properties
Complexity:
200
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
146.048g/mol
Formal Charge:
0
Heavy Atom Count:
11
Hydrogen Bond Acceptor Count:
1
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
146.149g/mol
Monoisotopic Mass:
146.048g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
41.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.7
Literature
| Title | Journal |
|---|---|
| Synthesis, in-vitro anticancer screening and radiosensitizing evaluation of some new N-(quinoxalin-2-yl)benzenesulfonamide derivatives. | Arzneimittel-Forschung 20120101 |
| Benzotriazinone and benzopyrimidinone derivatives as potent positive allosteric AMPA receptor modulators. | Bioorganic & medicinal chemistry letters 20111015 |
| Urea/thiourea derivatives of quinazolinone-lysine conjugates: synthesis and structure-activity relationships of a new series of antimicrobials. | European journal of medicinal chemistry 20110601 |
| Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents. | European journal of medicinal chemistry 20110201 |
| Structural requirements of N-substituted spiropiperidine analogues as agonists of nociceptin/orphanin FQ receptor. | International journal of molecular sciences 20110101 |
| Surface modification of silicone breast implants by binding the antifibrotic drug halofuginone reduces capsular fibrosis. | Plastic and reconstructive surgery 20100701 |
| Synthesis of dimeric quinazolin-2-one, 1,4-benzodiazepin-2-one, and isoalloxazine compounds as inhibitors of amyloid peptides association. | Archiv der Pharmazie 20090801 |
| Asymmetric synthesis of 2,3-dihydro-2-arylquinazolin-4-ones: methodology and application to a potent fluorescent tubulin inhibitor with anticancer activity. | Journal of medicinal chemistry 20080814 |
| The antihyperlipidemic activities of 4(3H) quinazolinone and two halogenated derivatives in rats. | Lipids in health and disease 20050101 |
| A novel 3D-QSAR comparative molecular field analysis (CoMFA) model of imidazole and quinazolinone functionalized p38 MAP kinase inhibitors. | Bioorganic & medicinal chemistry 20040615 |
| General scope of 1,4-diastereoselective additions to a 2(3H)-quinazolinone: practical preparation of HIV therapeutics. | The Journal of organic chemistry 20030207 |
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