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127373-66-4 | Propanoic acid, 2,2-dimethyl-, 4-[[[2-[[(carboxymethyl)amino]carbonyl]phenyl]amino]sulfonyl]phenyl ester
CAS No: 127373-66-4 Catalog No: AG000WZW MDL No:MFCD00889071
Product Description
Catalog Number:
AG000WZW
Chemical Name:
Propanoic acid, 2,2-dimethyl-, 4-[[[2-[[(carboxymethyl)amino]carbonyl]phenyl]amino]sulfonyl]phenyl ester
CAS Number:
127373-66-4
Molecular Formula:
C20H22N2O7S
Molecular Weight:
434.4629
MDL Number:
MFCD00889071
IUPAC Name:
2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetic acid
InChI:
InChI=1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24)
InChI Key:
BTGNGJJLZOIYID-UHFFFAOYSA-N
SMILES:
OC(=O)CNC(=O)c1ccccc1NS(=O)(=O)c1ccc(cc1)OC(=O)C(C)(C)C
UNII:
DWI62G0P59
Properties
Complexity:
731
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
434.115g/mol
Formal Charge:
0
Heavy Atom Count:
30
Hydrogen Bond Acceptor Count:
8
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
434.463g/mol
Monoisotopic Mass:
434.115g/mol
Rotatable Bond Count:
9
Topological Polar Surface Area:
147A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3
Literature
| Title | Journal |
|---|---|
| Potential of sivelestat in protection against severe acute pancreatitis-associated lung injury in rats. | Experimental lung research 20121101 |
| Direct interaction of ONO-5046 with human neutrophil elastase through ¹H NMR and molecular docking. | International journal of biological macromolecules 20121001 |
| Recent advancements of total aortic arch replacement. | The Journal of thoracic and cardiovascular surgery 20120701 |
| The effects of the early administration of sivelestat sodium, a selective neutrophil elastase inhibitor, on the postoperative course after radical surgery for esophageal cancer. | Surgery today 20120701 |
| [Esophageal cancer surgery for patients with chronic respiratory diseases]. | Kyobu geka. The Japanese journal of thoracic surgery 20120701 |
| Combined effects of a neutrophil elastase inhibitor (sivelestat sodium) and a free radical scavenger (edaravone) on lipopolysaccharide-induced acute lung injury in rats. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120601 |
| Aquaporin 4 and neuromyelitis optica. | The Lancet. Neurology 20120601 |
| Initial experience using Sivelestat to manage preterm labor with a bulging fetal membrane in pregnant women. | Journal of perinatology : official journal of the California Perinatal Association 20120601 |
| The effect of the neutrophil elastase inhibitor sivelestat on early injury after liver resection. | World journal of surgery 20120501 |
| Sialoglycoproteins adsorbed by Pseudomonas aeruginosa facilitate their survival by impeding neutrophil extracellular trap through siglec-9. | Journal of leukocyte biology 20120401 |
| Protective effect of an elastase inhibitor in a neuromyelitis optica-like disease driven by a peptide of myelin oligodendroglial glycoprotein. | Multiple sclerosis (Houndmills, Basingstoke, England) 20120401 |
| Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain. | Annals of neurology 20120301 |
| Administration of a specific inhibitor of neutrophil elastase attenuates pulmonary fibrosis after acute lung injury in mice. | Experimental lung research 20120201 |
| Inhaled neutrophil elastase inhibitor reduces oleic acid-induced acute lung injury in rats. | Pulmonary pharmacology & therapeutics 20120201 |
| Growth effect of neutrophil elastase on breast cancer: favorable action of sivelestat and application to anti-HER2 therapy. | Anticancer research 20120101 |
| Effects of phorbol myristate acetate and sivelestat on the lung injury caused by fat embolism in isolated lungs. | Journal of biomedical science 20120101 |
| [A case of docetaxel-induced acute lung injury refractory to treatment]. | Gan to kagaku ryoho. Cancer & chemotherapy 20120101 |
| Anesthetic Considerations in Hepatectomies under Hepatic Vascular Control. | HPB surgery : a world journal of hepatic, pancreatic and biliary surgery 20120101 |
| Clinical evaluation of sivelestat for acute lung injury/acute respiratory distress syndrome following surgery for abdominal sepsis. | Drug design, development and therapy 20120101 |
| Sivelestat relaxes vascular smooth muscle contraction in human gastric arteries. | Journal of physiology and biochemistry 20111201 |
| Reevaluation of the efficacy and safety of the neutrophil elastase inhibitor, Sivelestat, for the treatment of acute lung injury associated with systemic inflammatory response syndrome; a phase IV study. | Pulmonary pharmacology & therapeutics 20111001 |
| AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase. | The Journal of pharmacology and experimental therapeutics 20111001 |
| Early administration of sivelestat, the neutrophil elastase inhibitor, in adults for acute lung injury following gastric aspiration. | Shock (Augusta, Ga.) 20110901 |
| The effects of sivelestat sodium hydrate on uterine contraction and the concentration of maternal and fetal blood cytokines in a sheep model of intra-amniotic infection induced by lipopolysaccharide. | The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20110801 |
| Combination of extracorporeal membrane oxygenation and high-frequency oscillatory ventilation saved a child with severe ARDS after pulmonary resection. | Journal of anesthesia 20110801 |
| Effects of sivelestat on bronchial inflammatory responses after esophagectomy. | International journal of molecular medicine 20110801 |
| Design, synthesis and evaluation of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase. | Bioorganic & medicinal chemistry 20110801 |
| Optimal period for the prophylactic administration of neutrophil elastase inhibitor for patients with esophageal cancer undergoing esophagectomy. | World journal of surgery 20110701 |
| Perioperative use of a neutrophil elastase inhibitor in video-assisted thoracoscopic oesophagectomy for cancer. | The British journal of surgery 20110701 |
| Sivelestat suppresses iNOS gene expression in proinflammatory cytokine-stimulated hepatocytes. | Digestive diseases and sciences 20110601 |
| Simple phosphonic inhibitors of human neutrophil elastase. | Bioorganic & medicinal chemistry letters 20110301 |
| Protective effect of sivelestat, a neutrophil elastase inhibitor, on ipsilateral and contralateral testes after unilateral testicular ischaemia-reperfusion injury in rats. | BJU international 20110101 |
| A case of successful treatment with polymyxin B-immobilized fiber column direct hemoperfusion in acute respiratory distress syndrome after influenza A infection. | Internal medicine (Tokyo, Japan) 20110101 |
| Soluble endothelial selectin in acute lung injury complicated by severe pneumonia. | International journal of medical sciences 20110101 |
| Postoperative Acute Exacerbation of IPF after Lung Resection for Primary Lung Cancer. | Pulmonary medicine 20110101 |
| Plasminogen activator inhibitor-type I gene deficient mice show reduced influx of neutrophils in ventilator-induced lung injury. | Critical care research and practice 20110101 |
| The effect of sivelestat sodium hydrate on severe respiratory failure after thoracic aortic surgery with deep hypothermia. | Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 20110101 |
| Noninvasive in vivo quantification of neutrophil elastase activity in acute experimental mouse lung injury. | International journal of molecular imaging 20110101 |
| Influence of neutrophil elastase inhibitor on the postoperative course in patients with esophageal cancer after transthoracic esophagectomy. | Hepato-gastroenterology 20110101 |
| Prognostic factors in gastrointestinal perforation. | Hepato-gastroenterology 20110101 |
| Acute respiratory distress syndrome after gastrointestinal surgery. | Hepato-gastroenterology 20110101 |
| Differentiation syndrome in promyelocytic leukemia: clinical presentation, pathogenesis and treatment. | Mediterranean journal of hematology and infectious diseases 20110101 |
| The effect of selective neutrophil elastase inhibitor on pancreatic islet yields and functions in rat with hypercytokinemia. | Annals of transplantation 20110101 |
| Neutrophil elastase inhibitor restores gut ischemia reperfusion-induced impairment of gut immunity with reduced plasma interleukin-6 concentrations in mice. | Surgical infections 20101201 |
| Suppressive effects of sivelestat on interleukin 8 and TNF-α production from LPS-stimulated granulocytes in whole blood culture. | Journal of anesthesia 20101201 |
| A survey of the effects of sivelestat sodium administration on patients with postoperative respiratory dysfunction. | Surgery today 20101101 |
| Neutrophil elastase contributes to acute lung injury induced by bilateral nephrectomy. | The American journal of pathology 20101001 |
| In vivo efficacy of sivelestat in combination with pazufloxacin against Legionella pneumonia. | Experimental lung research 20101001 |
| Effect of a selective neutrophil elastase inhibitor on early recovery from body water imbalance after transthoracic esophagectomy. | Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 20100901 |
| Effects of a synthetic protease inhibitor (gabexate mesilate) and a neutrophil elastase inhibitor (sivelestat sodium) on acid-induced lung injury in rats. | European journal of pharmacology 20100901 |
| Neutrophil elastase promotes proliferation of HaCaT cell line and transwell psoriasis organ culture model. | International journal of dermatology 20100901 |
| Effects of neutrophil elastase inhibitor on progression of acute lung injury after liver transplantation. | Transplantation 20100815 |
| Postischemic infusion of sivelestat sodium hydrate, a selective neutrophil elastase inhibitor, protects against myocardial stunning in swine. | Journal of anesthesia 20100801 |
| Neutrophil elastase inhibitor prevents ischemic brain damage via reduction of vasogenic edema. | Hypertension research : official journal of the Japanese Society of Hypertension 20100701 |
| Effect of a neutrophil elastase inhibitor on acute lung injury after cardiopulmonary bypass. | Interactive cardiovascular and thoracic surgery 20100601 |
| Neutrophil elastase contributes to the development of ischemia/reperfusion-induced liver injury by decreasing the production of insulin-like growth factor-I in rats. | Translational research : the journal of laboratory and clinical medicine 20100601 |
| The protective function of neutrophil elastase inhibitor in liver ischemia/reperfusion injury. | Transplantation 20100515 |
| Prospective randomized controlled study on the effects of perioperative administration of a neutrophil elastase inhibitor to patients undergoing video-assisted thoracoscopic surgery for thoracic esophageal cancer. | Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 20100501 |
| Neutrophil elastase inhibitor improves survival of rats with clinically relevant sepsis. | Shock (Augusta, Ga.) 20100501 |
| The impact of oxidative stress levels on the clinical effectiveness of sivelestat in treating acute lung injury: an electron spin resonance study. | The Journal of trauma 20100401 |
| Efficacy of neutrophil elastase inhibitor on type A acute aortic dissection. | The Thoracic and cardiovascular surgeon 20100401 |
| Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome and disseminated intravascular coagulation patients. | Shock (Augusta, Ga.) 20100101 |
| Acute lung injury with alveolar hemorrhage due to a novel swine-origin influenza A (H1N1) virus. | Internal medicine (Tokyo, Japan) 20100101 |
| Platelet adhesion in the sinusoid caused hepatic injury by neutrophils after hepatic ischemia reperfusion. | Platelets 20100101 |
| Extracorporeal immune therapy with immobilized agonistic anti-Fas antibodies leads to transient reduction of circulating neutrophil numbers and limits tissue damage after hemorrhagic shock/resuscitation in a porcine model. | Journal of inflammation (London, England) 20100101 |
| DAMPening inflammation by modulating TLR signalling. | Mediators of inflammation 20100101 |
| Mechanical strength and viscoelastic response of the periodontal ligament in relation to structure. | Journal of dental biomechanics 20100101 |
| Prognostic impact of clinical course-specific mRNA expression profiles in the serum of perioperative patients with esophageal cancer in the ICU: a case control study. | Journal of translational medicine 20100101 |
| Effect of neutrophil elastase inhibitor (sivelestat sodium) in the treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): a systematic review and meta-analysis. | Internal medicine (Tokyo, Japan) 20100101 |
| Effects of elastase inhibitor on the epithelial cell apoptosis in bleomycin-induced pulmonary fibrosis. | Experimental lung research 20091201 |
| A pilot randomized study of the neutrophil elastase inhibitor, Sivelestat, in patients undergoing cardiac surgery. | Interactive cardiovascular and thoracic surgery 20090801 |
| Prevention of leukocyte activation by the neutrophil elastase inhibitor, sivelestat, in the hepatic microcirculation after ischemia-reperfusion. | The Journal of surgical research 20090801 |
| Sivelestat reduces myocardial ischemia and reperfusion injury in rat hearts even when administered after onset of myocardial ischemia. | Interactive cardiovascular and thoracic surgery 20090601 |
| Protective effect of sivelestat sodium hydrate (ONO-5046) on ischemic spinal cord injury. | Interactive cardiovascular and thoracic surgery 20090601 |
| Neutrophil elastase inhibitor (sivelestat) reduces the levels of inflammatory mediators by inhibiting NF-kB. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20090401 |
| Neutrophil elastase inhibitor attenuates hippocampal neuronal damage after transient forebrain ischemia in rats. | Brain research 20090309 |
| Neutrophil elastase activity compensates for a genetic lack of matrix metalloproteinase-9 (MMP-9) in leukocyte infiltration in a model of experimental peritonitis. | Journal of leukocyte biology 20090301 |
| Plasma neutrophil elastase and elafin imbalance is associated with acute respiratory distress syndrome (ARDS) development. | PloS one 20090101 |
| Resuscitation of haemorrhagic shock with normal saline vs. lactated Ringer's: effects on oxygenation, extravascular lung water and haemodynamics. | Critical care (London, England) 20090101 |
| Sivelestat treatment for acute respiratory distress syndrome in an infant. | Journal of anesthesia 20090101 |
| Inhibition of neutrophil elastase reduces lung injury and bacterial count in hamsters. | Pulmonary pharmacology & therapeutics 20081201 |
| Role of neutrophil elastase in development of pulmonary vascular injury and septic shock in rats. | Shock (Augusta, Ga.) 20081001 |
| The effect of sivelestat sodium on post-cardiopulmonary bypass acute lung injury in a neonatal piglet model. | Interactive cardiovascular and thoracic surgery 20081001 |
| Protective effect of sivelestat sodium (Eraspol) on postoperative lung dysfunction in patients with type A acute aortic dissection: a pilot study. | The Journal of cardiovascular surgery 20081001 |
| Sivelestat attenuates postoperative pulmonary dysfunction after total arch replacement under deep hypothermia. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20081001 |
| [Case of transfusion-related acute lung injury associated with severe intraoperative hypoxemia]. | Masui. The Japanese journal of anesthesiology 20081001 |
| [Efficacy of sivelestat for acute lung injury due to severe bacterial pneumonia with systemic inflammatory response syndrome]. | Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20081001 |
| A neutrophil elastase inhibitor, sivelestat, reduces lung injury following endotoxin-induced shock in rats by inhibiting HMGB1. | Inflammation 20080801 |
| Continuous infusion of sivelestat sodium hydrate prevents lipopolysaccharide-induced intestinal paralysis and hypotension in conscious guinea-pigs. | Clinical and experimental pharmacology & physiology 20080701 |
| Successful management of postoperative acute respiratory distress syndrome in a patient with lung cancer. | General thoracic and cardiovascular surgery 20080701 |
| Protective effect of Sivelestat in a porcine hepatectomy model prepared using an intermittent Pringle method. | European journal of pharmacology 20080610 |
| Neutrophil elastase activity in acute lung injury and respiratory distress syndrome. | Respirology (Carlton, Vic.) 20080601 |
| Sivelestat and its role in tissue reperfusion injury. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20080601 |
| [Effect of sivelestat sodium on acute lung injury after acute aortic dissection]. | Kyobu geka. The Japanese journal of thoracic surgery 20080601 |
| [Acute respiratory failure due to pneumocystis pneumonia successfully treated with combined use of sivelestat sodium hydrate]. | Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20080601 |
| Sivelestat relaxes porcine coronary artery via inhibition of Ca2+ sensitization induced by a receptor agonist. | Journal of cardiovascular pharmacology 20080501 |
| Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder. | Molecular and cellular biochemistry 20080401 |
| [Case of severe transfusion-related acute lung injury during coronary artery bypass surgery]. | Masui. The Japanese journal of anesthesiology 20080401 |
| [A case of lung adenocarcinoma effectively treated with sivelestat and corcicosteroid for drug-induced lung disease due to gefitinib]. | Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20080301 |
| Beneficial effect of neutrophil elastase inhibitor on anti-Thy1.1 nephritis in rats. | Nephrology (Carlton, Vic.) 20080201 |
| Severe Legionnaires' disease successfully treated using a combination of fluoroquinolone, erythromycin, corticosteroid, and sivelestat. | Internal medicine (Tokyo, Japan) 20080101 |
| Neutrophil Proteases Activate Eosinophil Function in vitro. | International archives of allergy and immunology 20080101 |
| Usefulness of a selective neutrophil elastase inhibitor (sivelestat) in septic ARDS patients after gastrointestinal surgery. | Hepato-gastroenterology 20080101 |
| A neutrophil elastase inhibitor, sivelestat, improved respiratory and cardiac function in pediatric cardiovascular surgery with cardiopulmonary bypass. | Journal of anesthesia 20080101 |
| Angiogenic activity of bFGF and VEGF suppressed by proteolytic cleavage by neutrophil elastase. | Biochemical and biophysical research communications 20071214 |
| Effects of sivelestat sodium hydrate on the reduction of radiation pneumonitis. | International journal of molecular medicine 20071201 |
| Addition of a neutrophil elastase inhibitor to the organ flushing solution decreases lung reperfusion injury in rat lung transplantation. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20071101 |
| Effects of neutrophil elastase inhibitor on progression of acute lung injury following esophagectomy. | World journal of surgery 20071001 |
| [Case of fulminant idiopathic interstitial pneumonia treated by sodium siverlestat (Elaspol) and steroid pulse therapy following extracorporeal lung assist (ECLA)]. | Masui. The Japanese journal of anesthesiology 20071001 |
| Neutrophil elastase inhibitor (sivelestat) attenuates subsequent ventilator-induced lung injury in mice. | European journal of pharmacology 20070924 |
| [Good response in ARDS treated with sivelestat sodium hydrate during chemotherapy for cholangiocarcinoma]. | Gan to kagaku ryoho. Cancer & chemotherapy 20070801 |
| Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice. | British journal of pharmacology 20070701 |
| Inhibition of neutrophil elastase attenuates gut mucosal injury evoked by acute alveolar hypoxia in rabbits. | Shock (Augusta, Ga.) 20070701 |
| [Outcome of patients with acute exacerbation of idiopathic interstitial fibrosis (IPF) treated with sivelestat and the prognostic value of serum KL-6 and surfactant protein D]. | Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20070601 |
| Neutrophil elastase inhibitor prevents endotoxin-induced liver injury following experimental partial hepatectomy. | The British journal of surgery 20070501 |
| [A case of legionella pneumonia associated with acute respiratory distress syndrome (ARDS) and acute renal failure treated with methylprednisolone and sivelestat]. | Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20070501 |
| Sivelestat reduces reperfusion injury of lungs harvested from endotoxin-primed rats by inhibition of neutrophil-mediated inflammation. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20070401 |
| Effects of specific neutrophil elastase inhibitor, sivelestat sodium hydrate, in murine model of severe pneumococcal pneumonia. | Experimental lung research 20070301 |
| A neutrophil elastase inhibitor, sivelestat, ameliorates lung injury after hemorrhagic shock in rats. | International journal of molecular medicine 20070201 |
| Neutrophil elastase induces cell proliferation and migration by the release of TGF-alpha, PDGF and VEGF in esophageal cell lines. | Oncology reports 20070101 |
| Neutrophil elastase inhibitor, sivelestat, attenuates acute lung injury after cardiopulmonary bypass in the rabbit endotoxemia model. | The Annals of thoracic surgery 20070101 |
| Invited commentary. | The Annals of thoracic surgery 20070101 |
| Neutrophil elastase inhibitor (sivelestat) preserves antitumor immunity and reduces the inflammatory mediators associated with major surgery. | Surgery today 20070101 |
| Neutrophil elastase as a predicting factor for development of acute lung injury. | Internal medicine (Tokyo, Japan) 20070101 |
| Neutrophil elastase inhibitor improves postoperative clinical courses after thoracic esophagectomy. | Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 20070101 |
| [A case of idiopathic ARDS treated by sivelestat sodium and fluid management based on extravascular lung water index]. | Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20061201 |
| Sivelestat relieves respiratory distress refractory to dexamethasone in all-trans retinoic acid syndrome: a report of two cases. | European journal of haematology 20061101 |
| ICAM-1 signal transduction in cells stimulated with neutrophil elastase. | Digestive diseases and sciences 20061101 |
| [Survival by a young woman with malnutrition due to alcoholism and eating disorders and with acute respiratory distress syndrome due to severe pneumonia who showed increased serum neutrophil elastase activity]. | Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 20061101 |
| Sivelestat, a specific neutrophil elastase inhibitor, suppresses the growth of gastric carcinoma cells by preventing the release of transforming growth factor-alpha. | Cancer science 20061001 |
| The effects of a neutrophil elastase inhibitor on the postoperative respiratory failure of acute aortic dissection. | The Thoracic and cardiovascular surgeon 20060901 |
| Benefical effect of neutrophil elastase inhibitor on renal warm ischemia-reperfusion injury in the rat. | Transplantation proceedings 20060901 |
| [Prophylactic effects of neutrophil elastase inhibitor for patients undergoing surgery for thoracic aortic aneurysm: a retrospective study]. | Masui. The Japanese journal of anesthesiology 20060801 |
| Pretreatment of sivelestat sodium hydrate improves the lung microcirculation and alveolar damage in lipopolysaccharide-induced acute lung inflammation in hamsters. | Shock (Augusta, Ga.) 20060701 |
| [Sivelestat sodium for aspiration-related acute lung injury: a review and analysis of published case reports]. | Masui. The Japanese journal of anesthesiology 20060601 |
| Application of chemical arrays in screening elastase inhibitors. | Combinatorial chemistry & high throughput screening 20060601 |
| A neutrophil elastase inhibitor, sivelestat, improves leukocyte deformability in patients with acute lung injury. | The Journal of trauma 20060501 |
| Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis. | Journal of gastroenterology 20060401 |
| ONO-5046 attenuation of delayed motor neuron death and effect on the induction of brain-derived neurotrophic factor, phosphorylated extracellular signal-regulated kinase, and caspase3 after spinal cord ischemia in rabbits. | The Journal of thoracic and cardiovascular surgery 20060301 |
| Update in ARDS management: recent randomized controlled trials that changed our practice. | Cleveland Clinic journal of medicine 20060301 |
| Clinical effects of a neutrophil elastase inhibitor, sivelestat, in patients with acute respiratory distress syndrome. | Journal of anesthesia 20060101 |
| [Two cases of acute respiratory failure due to idiopathic interstitial pneumonia successfully treated with sivelestat sodium hydrate and steroid therapy]. | Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20060101 |
| Effect of a polymorphonuclear elastase inhibitor (sivelestat sodium) on acute lung injury after cardiopulmonary bypass: findings of a double-blind randomized study. | Surgery today 20060101 |
| Effect of Ono-EI-600 elastase inhibitor on high-tidal-volume-induced lung injury in rats. | Journal of anesthesia 20060101 |
| Effects of sivelestat, a new elastase inhibitor, on IL-8 and MCP-1 production from stimulated human alveolar epithelial type II cells. | Journal of anesthesia 20060101 |
| Acute respiratory failure associated with miliary tuberculosis successfully treated with sivelestat sodium hydrate. | Internal medicine (Tokyo, Japan) 20060101 |
| Usefulness of sivelestat sodium administration in patients with aspiration pneumonia. | Journal of anesthesia 20060101 |
| Virus associated hemophagocytic syndrome accompanied by acute respiratory failure caused by influenza A (H3N2). | Internal medicine (Tokyo, Japan) 20060101 |
| Sivelestat sodium hydrate improves septic acute lung injury by reducing alveolar dysfunction. | Research communications in molecular pathology and pharmacology 20060101 |
| Sivelestat, a neutrophil elastase inhibitor, reduces mortality rate of critically ill patients. | The Tohoku journal of experimental medicine 20051001 |
| [Clinical experience of sivelestat sodium hydrate for severe reexpansion pulmonary edema; report of a case]. | Kyobu geka. The Japanese journal of thoracic surgery 20051001 |
| Epithelium-dependent and -independent inhibitory effects of sivelestat, a neutrophil elastase inhibitor, on substance P-induced contraction of airway smooth muscle in lipopolysaccharide-treated guinea-pigs. | Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20051001 |
| Sivelestat reduces inflammatory mediators and preserves neutrophil deformability during simulated extracorporeal circulation. | The Annals of thoracic surgery 20050801 |
| Protective effects of a selective neutrophil elastase inhibitor (sivelestat) on lipopolysaccharide-induced acute dysfunction of the pulmonary microcirculation. | Critical care medicine 20050801 |
| [Effects of neutrophil elastase inhibitor on postoperative cytokine levels in patients after esophagectomy]. | Masui. The Japanese journal of anesthesiology 20050801 |
| Case with bromine exposure leading to respiratory insufficiency. | Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology 20050401 |
| Sivelestat, a neutrophil elastase inhibitor, attenuates neutrophil priming after hepatoenteric ischemia in rabbits. | Shock (Augusta, Ga.) 20050201 |
| Cost-minimisation analysis of sivelestat for acute lung injury associated with systemic inflammatory response syndrome. | PharmacoEconomics 20050101 |
| Sivelestat, a specific neutrophil elastase inhibitor, prevented phorbol myristate acetate-induced acute lung injury in conscious rabbits. | Pulmonary pharmacology & therapeutics 20050101 |
| Neutrophil elastase inhibitor ameliorates reperfusion injury in a canine model of lung transplantation. | European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 20050101 |
| Neutrophil elastase contributes to the development of ischemia-reperfusion-induced liver injury by decreasing endothelial production of prostacyclin in rats. | American journal of physiology. Gastrointestinal and liver physiology 20041201 |
| [Respiratory and cadiovascular management of septic ALI-ARDS and shock]. | Nihon rinsho. Japanese journal of clinical medicine 20041201 |
| Effects of granulocyte colony-stimulating factor (G-CSF) and neutrophil elastase inhibitor (ONO-5046) on acid-induced lung injury in rats. | Inflammation 20041201 |
| [A case of Legionella pneumonia complicated with acute respiratory distress syndrome treated with methylprednisolone and sivelestat sodium in combination with intravenous erythromycin and ciprofloxacin]. | Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20041101 |
| Pilot study of the effects of ONO-5046 in patients with acute respiratory distress syndrome. | Anesthesia and analgesia 20040901 |
| [Sivelestat sodium hydrate was effective for ARDS in a patient suffering from chronic rheumatoid arthritis with acute exacerbation after failing to respond to high dose steroid pulse therapy]. | Masui. The Japanese journal of anesthesiology 20040901 |
| Neutrophil elastase inhibition in acute lung injury: results of the STRIVE study. | Critical care medicine 20040801 |
| Hidden evidence to the West: multicentre, randomised, controlled trials in sepsis and systemic inflammatory response syndrome in Japanese journals. | Intensive care medicine 20040501 |
| Elastase inhibition reduced death associated with acid aspiration-induced lung injury in hamsters. | European journal of pharmacology 20040319 |
| Relationship between neutrophil elastase and acute lung injury in humans. | Pulmonary pharmacology & therapeutics 20040101 |
| Stat6-protease but not Stat5-protease is inhibited by an elastase inhibitor ONO-5046. | Biochemical and biophysical research communications 20031003 |
| [Pharmacological profile of a specific neutrophil elastase inhibitor, Sivelestat sodium hydrate]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20030801 |
| Effect of sivelestat, an inhibitor of neutrophil elastase, on rapidly progressive glomerulonephritis. | Clinical nephrology 20030801 |
| The effects of a specific neutrophil elastase inhibitor (ONO-5046) in pulmonary ischemia-reperfusion injury. | Transplant international : official journal of the European Society for Organ Transplantation 20030501 |
| A pulmonary metastatic model of human non-small cell lung carcinoma cells that produce a neutrophil elastase-like molecule in severe combined immunodeficiency mice. | Chest 20030401 |
| Therapy for chronic obstructive pulmonary disease in the 21st century. | Drugs 20030101 |
| Clarification of mechanism of human sputum elastase inhibition by a new inhibitor, ONO-5046, using electrospray ionization mass spectrometry. | Bioorganic & medicinal chemistry letters 20020902 |
| Neutrophil elastase inhibitor attenuates lipopolysaccharide-induced hepatic microvascular dysfunction in mice. | Shock (Augusta, Ga.) 20020801 |
| Neutrophil elastase and acute lung injury: prospects for sivelestat and other neutrophil elastase inhibitors as therapeutics. | Critical care medicine 20020501 |
| Role of elastase and active oxygen species in gastric mucosal injury induced by aspirin administration in Helicobacter pylori-infected Mongolian gerbils. | Alimentary pharmacology & therapeutics 20020401 |
| Neutrophil elastase inhibitor reduces hepatic metastases induced by ischaemia-reperfusion in rats. | The European journal of surgery = Acta chirurgica 20020101 |
| Effects of neutrophil elastase inhibitor (ONO-5046) on lung injury after intestinal ischemia-reperfusion. | Journal of applied physiology (Bethesda, Md. : 1985) 20011001 |
| A neutrophil elastase inhibitor (ONO-5046) reduces neurologic damage after spinal cord injury in rats. | Journal of neurochemistry 20010901 |
| Inhibition of neutrophil elastase activity attenuates complement-mediated lung injury in the hamster. | European journal of pharmacology 20010824 |
| Effect of a neutrophil elastase inhibitor (ONO-5046 Na) on ischemia/reperfusion injury using the left-sided heterotopic canine heart transplantation model. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20010801 |
| Inhibitory effect of serine protease inhibitors on neutrophil-mediated endothelial cell injury. | Journal of leukocyte biology 20010201 |
| Protease inhibitors: current status and future prospects. | Journal of medicinal chemistry 20000210 |
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