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127294-70-6 | 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[3-(methylamino)-1-piperidinyl]-4-oxo-
CAS No: 127294-70-6 Catalog No: AG000WWF MDL No:MFCD00864925
Product Description
Catalog Number:
AG000WWF
Chemical Name:
3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[3-(methylamino)-1-piperidinyl]-4-oxo-
CAS Number:
127294-70-6
Molecular Formula:
C20H24FN3O4
Molecular Weight:
389.4207
MDL Number:
MFCD00864925
IUPAC Name:
1-cyclopropyl-6-fluoro-8-methoxy-7-[3-(methylamino)piperidin-1-yl]-4-oxoquinoline-3-carboxylic acid
InChI:
InChI=1S/C20H24FN3O4/c1-22-11-4-3-7-23(9-11)17-15(21)8-13-16(19(17)28-2)24(12-5-6-12)10-14(18(13)25)20(26)27/h8,10-12,22H,3-7,9H2,1-2H3,(H,26,27)
InChI Key:
MGQLHRYJBWGORO-UHFFFAOYSA-N
SMILES:
CNC1CCCN(C1)c1c(F)cc2c(c1OC)n(cc(c2=O)C(=O)O)C1CC1
Properties
Complexity:
668
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
389.175g/mol
Formal Charge:
0
Heavy Atom Count:
28
Hydrogen Bond Acceptor Count:
8
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
389.427g/mol
Monoisotopic Mass:
389.175g/mol
Rotatable Bond Count:
5
Topological Polar Surface Area:
82.1A^2
Undefined Atom Stereocenter Count:
1
Undefined Bond Stereocenter Count:
0
XLogP3:
0.6
Literature
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|---|---|
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| Downregulation of Na(+)-NQR complex is essential for Vibrio alginolyticus in resistance to balofloxacin. | Journal of proteomics 20120517 |
| In the quest of drugs for bad bugs: are newer fluoroquinolones any better? | Journal of laboratory physicians 20110101 |
| Synthesis and in vitro antimycobacterial activity of balofloxacin ethylene isatin derivatives. | European journal of medicinal chemistry 20100801 |
| Aquatic photochemistry of fluoroquinolone antibiotics: kinetics, pathways, and multivariate effects of main water constituents. | Environmental science & technology 20100401 |
| Gatifloxacin, moxifloxacin, and balofloxacin resistance due to mutations in the gyrA and parC genes of Staphylococcus epidermidis strains isolated from patients with endophthalmitis, corneal ulcers and conjunctivitis. | Ophthalmic research 20090101 |
| Ethyl 1-cyclo-propyl-6,7-difluoro-8-meth-oxy-4-oxo-1,4-dihydro-quinoline-3-carboxyl-ate. | Acta crystallographica. Section E, Structure reports online 20081101 |
| [Synthesis and antibacterial activity of 7-(3-amino-4-alkoxyimino-1 -piperidyl) -quinolones]. | Yao xue xue bao = Acta pharmaceutica Sinica 20080801 |
| [Determination of balofloxacin in human plasma by HPLC with solid-phase extraction]. | Se pu = Chinese journal of chromatography 20071101 |
| High performance liquid chromatography-electrospray ionization mass spectrometric determination of balofloxacin in human plasma and its pharmacokinetics. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070501 |
| [Studies on the reaction of balofloxacin with bovine serum albumin]. | Guang pu xue yu guang pu fen xi = Guang pu 20060801 |
| Electrophysiological safety of novel fluoroquinolone antibiotic agents gemifloxacin and balofloxacin. | Drug and chemical toxicology 20060101 |
| [Interaction between balofloxacin and DNA and the influence of Mg2+ on the interaction]. | Yao xue xue bao = Acta pharmaceutica Sinica 20050701 |
| Balofloxacin Choongwae. | Current opinion in investigational drugs (London, England : 2000) 20030201 |
| [In vitro antimycobacterial activities of a new quinolone, balofloxacin]. | Kekkaku : [Tuberculosis] 20010101 |
| History of quinolones and their side effects. | Chemotherapy 20010101 |
| [In vitro anti-MAC activities of new quinolones in focus (2)]. | Kekkaku : [Tuberculosis] 19960901 |
| [Determination of antimycobacterial activities of fluoroquinolones against clinical isolates of Mycobacterium tuberculosis: comparative determination with egg-based Ogawa and agar-based Middlebrook 7H10 media]. | Kekkaku : [Tuberculosis] 19960801 |
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