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127191-97-3

127191-97-3 | 5-Isoquinolinesulfonic acid, 4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester

CAS No: 127191-97-3 Catalog No: AG000WQW MDL No:MFCD00083180

Product Description

Catalog Number:
AG000WQW
Chemical Name:
5-Isoquinolinesulfonic acid, 4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester
CAS Number:
127191-97-3
Molecular Formula:
C38H35N5O6S2
Molecular Weight:
721.8444
MDL Number:
MFCD00083180
IUPAC Name:
[4-[(2S)-2-[isoquinolin-5-ylsulfonyl(methyl)amino]-3-oxo-3-(4-phenylpiperazin-1-yl)propyl]phenyl] isoquinoline-5-sulfonate
InChI:
InChI=1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3/t35-/m0/s1
InChI Key:
RJVLFQBBRSMWHX-DHUJRADRSA-N
SMILES:
O=C([C@H](Cc1ccc(cc1)OS(=O)(=O)c1cccc2c1ccnc2)NCS(=O)(=O)c1cccc2c1ccnc2)N1CCN(CC1)c1ccccc1
UNII:
63HM46XPOW

Properties

Complexity:
1370  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
721.203g/mol
Formal Charge:
0
Heavy Atom Count:
51  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
721.847g/mol
Monoisotopic Mass:
721.203g/mol
Rotatable Bond Count:
10  
Topological Polar Surface Area:
147A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
5.6  

Literature

Title Journal
An in vitro skin sensitization assay termed EpiSensA for broad sets of chemicals including lipophilic chemicals and pre/pro-haptens. Toxicology in vitro : an international journal published in association with BIBRA 20170401
Plasticizer DBP Activates NLRP3 Inflammasome through the P2X7 Receptor in HepG2 and L02 Cells. Journal of biochemical and molecular toxicology 20160401
Toluene diisocyanate: Induction of the autotaxin-lysophosphatidic acid axis and its association with airways symptoms. Toxicology and applied pharmacology 20150915
Involvement of CaM-CaMKII-ERK in bisphenol A-induced Sertoli cell apoptosis. Toxicology 20141003
Identification of potent Yes1 kinase inhibitors using a library screening approach. Bioorganic & medicinal chemistry letters 20130801
Neuroprotective effect of resveratrol on ischemia/reperfusion injury in rats through TRPC6/CREB pathways. Journal of molecular neuroscience : MN 20130701
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. The Biochemical journal 20130415
Calcium/calmodulin-dependent protein kinase II regulates IL-10 production by human T lymphocytes: a distinct target in the calcium dependent pathway. Molecular immunology 20120901
NOX2-dependent ROS is required for HDAC5 nuclear efflux and contributes to HDAC4 nuclear efflux during intense repetitive activity of fast skeletal muscle fibers. American journal of physiology. Cell physiology 20120801
Pannexin1-mediated ATP release provides signal transmission between Neuro2A cells. Neurochemical research 20120601
Structure-activity relationships and optimization of 3,5-dichloropyridine derivatives as novel P2X(7) receptor antagonists. Journal of medicinal chemistry 20120426
Purinergic P2X7 receptors participate in disturbed intracellular calcium homeostasis in peripheral blood mononuclear cells of patients with chronic kidney disease. Kidney & blood pressure research 20120101
The affinity of histamine for Gq protein-coupled histamine H(1)-receptors is predominantly regulated by their internalization in human astrocytoma cells. Journal of pharmacological sciences 20120101
Exocrine pancreatic carcinogenesis and autotaxin expression. PloS one 20120101
Adipocyte P2X7 receptors expression: a role in modulating inflammatory response in subjects with metabolic syndrome? Atherosclerosis 20111201
CRP1, a protein localized in filopodia of growth cones, is involved in dendritic growth. The Journal of neuroscience : the official journal of the Society for Neuroscience 20111116
Pharmacological properties of the rhesus macaque monkey P2X7 receptor. British journal of pharmacology 20110901
Involvement of histaminergic receptor mechanisms in the stimulation of NT-3 synthesis in astrocytes. Neuropharmacology 20110601
NMDA preconditioning protects against quinolinic acid-induced seizures via PKA, PI3K and MAPK/ERK signaling pathways. Behavioural brain research 20110516
TGF-β-activated kinase 1 mediates mechanical stress-induced IL-6 expression in osteoblasts. Biochemical and biophysical research communications 20110506
Characterization of protoberberine analogs employed as novel human P2X7 receptor antagonists. Toxicology and applied pharmacology 20110415
Requirement for non-regulated, constitutive calcium influx in macrophage survival signaling. Biochemical and biophysical research communications 20110408
LTP in hippocampal neurons is associated with a CaMKII-mediated increase in GluA1 surface expression. Journal of neurochemistry 20110201
Calmodulin and calmodulin-dependent protein kinase II inhibit hormone secretion in human parathyroid adenoma. The Journal of endocrinology 20110101
4-aminopyridine induces apoptosis of human acute myeloid leukemia cells via increasing [Ca2+]i through P2X7 receptor pathway. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101
Targeting P2X₇ receptor inhibits the metastasis of murine P388D1 lymphoid neoplasm cells to lymph nodes. Cell biology international 20101201
Pathways for ATP release by bovine ciliary epithelial cells, the initial step in purinergic regulation of aqueous humor inflow. American journal of physiology. Cell physiology 20101201
TGF-β1 prevents up-regulation of the P2X7 receptor by IFN-γ and LPS in leukemic THP-1 monocytes. Biochimica et biophysica acta 20101101
Mechanism of inhibition of acetylcholine secretion in newly formed mouse synapses involving Ca2+-dependent kinases and voltage-gated K+-channels. Bulletin of experimental biology and medicine 20100801
Osthole or imperatorin-mediated facilitation of glutamate release is associated with a synaptic vesicle mobilization in rat hippocampal glutamatergic nerve endings. Synapse (New York, N.Y.) 20100501
Shockwaves increase T-cell proliferation and IL-2 expression through ATP release, P2X7 receptors, and FAK activation. American journal of physiology. Cell physiology 20100301
Delayed intrinsic activation of an NMDA-independent CaM-kinase II in a critical time window is necessary for late consolidation of an associative memory. The Journal of neuroscience : the official journal of the Society for Neuroscience 20100106
Rebound bursts in GABAergic neurons of the thalamic reticular nucleus in postnatal mice. Physiological research 20100101
Vacuolar ATPase regulates surfactant secretion in rat alveolar type II cells by modulating lamellar body calcium. PloS one 20100101
Defining the antigen receptor-dependent regulatory network that induces arrest of cycling immature B-lymphocytes. BMC systems biology 20100101
Synthesis and structure-activity relationships of pyrazolodiazepine derivatives as human P2X7 receptor antagonists. Bioorganic & medicinal chemistry letters 20091101
Acetylcholine rescues two-cell block through activation of IP3 receptors and Ca2+/calmodulin-dependent kinase II in an ICR mouse strain. Pflugers Archiv : European journal of physiology 20091001
Modulation of K(ATP) currents in rat ventricular myocytes by hypoxia and a redox reaction. Acta pharmacologica Sinica 20091001
Role of calcineurin-mediated dephosphorylation in modulation of an inwardly rectifying K+ channel in human proximal tubule cells. The Journal of membrane biology 20091001
A highly energetic process couples calcium influx through L-type calcium channels to insulin secretion in pancreatic beta-cells. American journal of physiology. Endocrinology and metabolism 20090901
A role for calcium-calmodulin-dependent protein kinase II in the consolidation of visual object recognition memory. The European journal of neuroscience 20090901
P2X7-mediated increased intracellular calcium causes functional derangement in Schwann cells from rats with CMT1A neuropathy. The Journal of biological chemistry 20090821
Purinergic P2X(7) receptor antagonists: Chemistry and fundamentals of biological screening. Bioorganic & medicinal chemistry 20090715
Up-regulation of ZO-1 expression and barrier function in cultured human corneal epithelial cells by substance P. FEBS letters 20090618
Expression of the dominant-negative tail of myosin Va enhances exocytosis of large dense core vesicles in neurons. Cellular and molecular neurobiology 20090601
Antagonists of the P2X(7) receptor. From lead identification to drug development. Journal of medicinal chemistry 20090528
Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells. Toxicology and applied pharmacology 20090515
The role of P2X7 receptor in ATP-mediated human leukemia cell death: calcium influx-independent. Acta biochimica et biophysica Sinica 20090501
Astrocyte cultures exhibit P2X7 receptor channel opening in the absence of exogenous ligands. Glia 20090415
Synthesis and structure-activity relationships of novel, substituted 5,6-dihydrodibenzo[a,g]quinolizinium P2X7 antagonists. Bioorganic & medicinal chemistry letters 20090201
Search for inhibitors of bacterial and human protein kinases among derivatives of diazepines[1,4] annelated with maleimide and indole cycles. Journal of medicinal chemistry 20081225
Destabilization of the postsynaptic density by PSD-95 serine 73 phosphorylation inhibits spine growth and synaptic plasticity. Neuron 20081210
Identification of regions of the P2X(7) receptor that contribute to human and rat species differences in antagonist effects. British journal of pharmacology 20081101
CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes. Cell metabolism 20081101
P2X7 receptor-Pannexin1 complex: pharmacology and signaling. American journal of physiology. Cell physiology 20080901
Silencing-induced metaplasticity in hippocampal cultured neurons. Journal of neurophysiology 20080801
Constitutive activity of inwardly rectifying K+ channel at physiological [Ca]i is mediated by Ca2+/CaMK II pathway in opossum kidney proximal tubule cells. The journal of physiological sciences : JPS 20080601
[Effects of chronic hypoxia on the expression of calmodulin and calcicum/calmodulin-dependent protein kinase II and the calcium activity in myocardial cells in young rats]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20080601
Receptor-mediated tobacco toxicity: acceleration of sequential expression of alpha5 and alpha7 nicotinic receptor subunits in oral keratinocytes exposed to cigarette smoke. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080501
Induction of nuclear receptors and drug resistance in the brain microvascular endothelial cells treated with antiepileptic drugs. Current neurovascular research 20080501
Depolarization-induced differentiation of PC12 cells is mediated by phospholipase D2 through the transcription factor CREB pathway. Journal of neurochemistry 20080301
A plant Ca2+ pump, ACA2, relieves salt hypersensitivity in yeast. Modulation of cytosolic calcium signature and activation of adaptive Na+ homeostasis. The Journal of biological chemistry 20080208
Role for calcium in the development of ovarial patency in Heliothis virescens. Journal of insect physiology 20080201
Cloning and pharmacological characterization of the guinea pig P2X7 receptor orthologue. British journal of pharmacology 20080201
Negative and positive allosteric modulators of the P2X(7) receptor. British journal of pharmacology 20080201
Synthesis and structure-activity relationship studies of tyrosine-based antagonists at the human P2X7 receptor. Bioorganic & medicinal chemistry letters 20080115
Extracellular ATP mediates necrotic cell swelling in SN4741 dopaminergic neurons through P2X7 receptors. The Journal of biological chemistry 20071228
Functional expression of ionotropic purinergic receptors on mouse taste bud cells. The Journal of physiology 20071015
Behavioral modulation of neuronal calcium/calmodulin-dependent protein kinase II activity: differential effects on nicotine-induced spinal and supraspinal antinociception in mice. Biochemical pharmacology 20071015
Contribution of two ionotropic purinergic receptors to ATP responses in submandibular gland ductal cells. Cellular signalling 20071001
Calcium/calmodulin-dependent kinase activity is required for efficient induction of osteoclast differentiation and bone resorption by receptor activator of nuclear factor kappa B ligand (RANKL). Journal of cellular physiology 20070901
A quantitative method for routine measurement of cell surface P2X7 receptor function in leucocyte subsets by two-colour time-resolved flow cytometry. Journal of immunological methods 20070831
Hepatocyte growth factor-induced enhancement of dendritic branching is blocked by inhibitors of N-methyl-D-aspartate receptors and calcium/calmodulin-dependent kinases. Journal of neuroscience research 20070815
From tyrosine to glycine: synthesis and biological activity of potent antagonists of the purinergic P2X7 receptor. Journal of medicinal chemistry 20070726
KN-62 analogues as potent differentiating agents of HL-60 cells. Leukemia research 20070501
Multiple P2X receptors are involved in the modulation of apoptosis in human mesangial cells: evidence for a role of P2X4. American journal of physiology. Renal physiology 20070501
CaMKII regulates retinoic acid receptor transcriptional activity and the differentiation of myeloid leukemia cells. The Journal of clinical investigation 20070501
Corticotropin-releasing hormone or dexamethasone regulates rat proopiomelanocortin transcription through Tpit/Pitx-responsive element in its promoter. The Journal of endocrinology 20070501
Calcium signalling in the regulation of PGC-1alpha, PDK4 and HKII mRNA expression. Biological chemistry 20070501
Activity-dependent initiation of a prolonged depolarization in aplysia bag cell neurons: role for a cation channel. Journal of neurophysiology 20070301
The select action of hippocampal calcium calmodulin protein kinase II in mediating exercise-enhanced cognitive function. Neuroscience 20070209
Stimulation of adenosine A1 and A2A receptors by AMP in the submucosal plexus of guinea pig small intestine. American journal of physiology. Gastrointestinal and liver physiology 20070201
Microarray-based kinase inhibition assay by gold nanoparticle probes. Analytical chemistry 20070115
Stimulation of fibroblast proliferation by neokyotorphin requires Ca influx and activation of PKA, CaMK II and MAPK/ERK. The FEBS journal 20070101
Life and death in bovine monocytes: the fate of Mycobacterium avium subsp. paratuberculosis. Microbial pathogenesis 20070101
The retinoic acid receptor/CaMKII interaction: pharmacologic inhibition of CaMKII enhances the differentiation of myeloid leukemia cells. Blood cells, molecules & diseases 20070101
Cocaine activates calcium/calmodulin kinase II and causes cardiomyocyte hypertrophy. Journal of cardiovascular pharmacology 20060701
Modulation by LL-37 of the responses of salivary glands to purinergic agonists. Molecular pharmacology 20060601
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Activation of P2Y1 receptor triggers two calcium signaling pathways in bone marrow erythroblasts. European journal of pharmacology 20060318
Pore properties and pharmacological features of the P2X receptor channel in airway ciliated cells. The Journal of physiology 20060315
Internalization and desensitization of a green fluorescent protein-tagged P2Y nucleotide receptor are differently controlled by inhibition of calmodulin-dependent protein kinase II. Journal of neurochemistry 20060201
Overexpression of calbindin-D28K in hippocampal progenitor cells increases neuronal differentiation and neurite outgrowth. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060101
Cocaine inhibition of GABA(A) current: role of dephosphorylation. Critical reviews in neurobiology 20060101
Modulation of intracellular Ca2+ release and capacitative Ca2+ entry by CaMKII inhibitors in bovine vascular endothelial cells. American journal of physiology. Cell physiology 20051201
N-Arylpiperazine modified analogues of the P2X7 receptor KN-62 antagonist are potent inducers of apoptosis of human primary osteoclasts. Journal of biomedical science 20051201
Calcium-acting drugs modulate expression and development of chronic tolerance to nicotine-induced antinociception in mice. The Journal of pharmacology and experimental therapeutics 20051101
Calcium/calmodulin-dependent protein kinase II (CaMKII), through NMDA receptors and L-Voltage-gated channels, modulates the serine phosphorylation of GluR6 during cerebral ischemia and early reperfusion period in rat hippocampus. Brain research. Molecular brain research 20051031
Gonadotropin-releasing hormone induction of extracellular-signal regulated kinase is blocked by inhibition of calmodulin. Molecular endocrinology (Baltimore, Md.) 20050901
Human melanomas express functional P2 X(7) receptors. Cell and tissue research 20050901
Human epidermal and monocyte-derived langerhans cells express functional P2X receptors. The Journal of investigative dermatology 20050901
Netrin-1 induces axon branching in developing cortical neurons by frequency-dependent calcium signaling pathways. The Journal of neuroscience : the official journal of the Society for Neuroscience 20050713
Effects of 17beta-estradiol on chemically induced long-term depression. Neuropharmacology 20050701
Neuroprotective effects of preconditioning ischemia on ischemic brain injury through down-regulating activation of JNK1/2 via N-methyl-D-aspartate receptor-mediated Akt1 activation. The Journal of biological chemistry 20050610
The role of intracellular Ca2+ in the regulation of proteinase-activated receptor-2 mediated nuclear factor kappa B signalling in keratinocytes. British journal of pharmacology 20050601
Activation of CREB by tauroursodeoxycholic acid protects cholangiocytes from apoptosis induced by mTOR inhibition. Hepatology (Baltimore, Md.) 20050601
Decreases in CaMKII activity trigger persistent potentiation of intrinsic excitability in spontaneously firing vestibular nucleus neurons. Neuron 20050519
Nuclear Ca2+ and CaM kinase IV specify hormonal- and Notch-responsiveness. Journal of neurochemistry 20050401
Activity-dependent long-term potentiation of intrinsic excitability in hippocampal CA1 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 20050216
Somatodendritic autoreceptor regulation of serotonergic neurons: dependence on L-tryptophan and tryptophan hydroxylase-activating kinases. The European journal of neuroscience 20050201
Heterologous desensitization of insulin secretion by GIP (glucose-dependent insulinotropic peptide) in INS-1 cells: the significance of Galphai2 and investigations on the mechanism involved. Cell biochemistry and function 20050101
Extracellular zinc triggers ERK-dependent activation of Na+/H+ exchange in colonocytes mediated by the zinc-sensing receptor. The Journal of biological chemistry 20041210
AMP-activated protein kinase: a new beta-cell glucose sensor?: Regulation by amino acids and calcium ions. Diabetes 20041201
Chlamydophila pneumoniae induces p44/p42 mitogen-activated protein kinase activation in human fibroblasts through Toll-like receptor 4. Journal of medical microbiology 20041201
Synthesis, radiolabeling, and preliminary biological evaluation of [3H]-1-[(S)-N,O-bis-(isoquinolinesulfonyl)-N-methyl-tyrosyl]-4-(o-tolyl)-piperazine, a potent antagonist radioligand for the P2X7 receptor. Bioorganic & medicinal chemistry letters 20041115
Extracellular ATP increases cation fluxes in human erythrocytes by activation of the P2X7 receptor. The Journal of biological chemistry 20041022
Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motoneurones. British journal of pharmacology 20041001
Enhanced P2X7 activity in human fibroblasts from diabetic patients: a possible pathogenetic mechanism for vascular damage in diabetes. Arteriosclerosis, thrombosis, and vascular biology 20040701
Chelerythrine and other benzophenanthridine alkaloids block the human P2X7 receptor. British journal of pharmacology 20040701
Endothelin 1 and 3 enhance neuronal nitric oxide synthase activity through ETB receptors involving multiple signaling pathways in the rat anterior hypothalamus. Peptides 20040701
KN-62, a selective inhibitor of Ca(2+)/calmodulin-dependent protein kinase II, inhibits the lysozyme pre-mRNA splicing in myelomonocytic HD11 cells. Biochemical and biophysical research communications 20040625
Diurnal, circadian and photic regulation of calcium/calmodulin-dependent kinase II and neuronal nitric oxide synthase in the hamster suprachiasmatic nuclei. Neurochemistry international 20040601
Brain ischemia induces serine phosphorylation of neuronal nitric oxide synthase by Ca(2+)/calmodulin-dependent protein kinase II in rat hippocampus. Acta pharmacologica Sinica 20040501
A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release. Journal of immunology (Baltimore, Md. : 1950) 20040415
Signaling pathway of magnolol-stimulated lipolysis in sterol ester-loaded 3T3-L1 preadipocyes. Journal of cellular biochemistry 20040401
Pavlovian fear conditioning regulates Thr286 autophosphorylation of Ca2+/calmodulin-dependent protein kinase II at lateral amygdala synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience 20040331
Ca2+ and AMPK both mediate stimulation of glucose transport by muscle contractions. Diabetes 20040201
Evidence that protein kinase Cdelta is not required for palmitate-induced cytotoxicity in BRIN-BD11 beta-cells. Journal of molecular endocrinology 20040201
Competitive binding of postsynaptic density 95 and Ca2+-calmodulin dependent protein kinase II to N-methyl-D-aspartate receptor subunit 2B in rat brain. Acta pharmacologica Sinica 20040201
A role for calcium/calmodulin kinase in insulin stimulated glucose transport. Life sciences 20040102
NMDA receptor-mediated immediate Ser831 phosphorylation of GluR1 through CaMKIIalpha in rat hippocampus during early global ischemia. Neuroscience research 20040101
Nicotinamide relaxes vascular smooth muscle by inhibiting myosin light chain kinase-dependent signaling pathways: implications for anticancer efficacy. Oncology research 20040101
Agonists and antagonists acting at P2X7 receptor. Current topics in medicinal chemistry 20040101
Dissecting individual current components of co-expressed human P2X1 and P2X7 receptors. Current topics in medicinal chemistry 20040101
Inhibition of lipopolysaccharide/ATP-induced release of interleukin-18 by KN-62 and glyburide. European journal of pharmacology 20031215
Hit-to-Lead studies: the discovery of potent adamantane amide P2X7 receptor antagonists. Bioorganic & medicinal chemistry letters 20031117
Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1. Journal of neurochemistry 20031101
Cerebral ischemia immediately increases serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP by calcium/calmodulin-dependent protein kinase II alpha in hippocampus of rats. Neuroscience letters 20031009
Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor. The Journal of physiology 20030901
Beta-adrenergic stimulation induces cardiac ankyrin repeat protein expression: involvement of protein kinase A and calmodulin-dependent kinase. Cardiovascular research 20030901
Striatal proenkephalin gene induction: coordinated regulation by cyclic AMP and calcium pathways. Brain research. Molecular brain research 20030723
Regulation of ERK phosphorylation by ethanol in fetal cortical neurons. Neurochemical research 20030501
Ca2+/calmodulin-dependent protein kinases II and IV both promote survival but differ in their effects on axon growth in spiral ganglion neurons. Journal of neuroscience research 20030415
Synthesis and biological activity of N-arylpiperazine-modified analogues of KN-62, a potent antagonist of the purinergic P2X7 receptor. Journal of medicinal chemistry 20030410
Insulin-stimulated cyclic guanosine monophosphate inhibits vascular smooth muscle cell migration by inhibiting Ca/calmodulin-dependent protein kinase II. Circulation 20030325
Ameliorative effect of NC-1900, a new AVP4-9 analog, through vasopressin V1A receptor on scopolamine-induced impairments of spatial memory in the eight-arm radial maze. Neuropharmacology 20030301
Calmodulin and calmodulin-dependent kinase II mediate neuronal cell death induced by depolarization. Brain research 20030207
The role of the nuclear receptor CAR as a coordinate regulator of hepatic gene expression in defense against chemical toxicity. Archives of biochemistry and biophysics 20030101
Formation of AP-1 transcription factors during learning in Helix. Neuroscience and behavioral physiology 20030101
A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus. Neuroscience 20030101
c-IAP1 is overexpressed in HL-60 cells selected for doxorubicin resistance: effects on etoposide-induced apoptosis. Anticancer research 20030101
Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin. The Journal of biological chemistry 20021122
Proteasome-driven turnover of tryptophan hydroxylase is triggered by phosphorylation in RBL2H3 cells, a serotonin producing mast cell line. European journal of biochemistry 20021001
Postsynaptic kinase signaling underlies inhibitory synaptic plasticity in the lateral superior olive. Journal of neurobiology 20021001
KN-62 enhances Chlamydia pneumoniae-induced p44/p42 mitogen-activated protein kinase activation in murine fibroblasts and attenuates in vitro infection. FEMS microbiology letters 20020924
Purine and pyrimidine (P2) receptors as drug targets. Journal of medicinal chemistry 20020912
Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells. The Journal of endocrinology 20020801
Ca(2+)/calmodulin-dependent protein kinase (CaM-kinase) inhibitor KN-62 suppresses the activity of mitogen-activated protein kinase (MAPK), c-myc activation and human keratinocyte proliferation. Archives of dermatological research 20020701
CaMKII regulates amphetamine-induced ERK1/2 phosphorylation in striatal neurons. Neuroreport 20020612
CaMKII is activated and translocated to the secretory apical membrane during cholinergically conveyed gastric acid secretion. Cellular signalling 20020201
Pharmacological characterization of the P2X(7) receptor on human macrophages using the patch-clamp technique. Naunyn-Schmiedeberg's archives of pharmacology 20020201
Protein kinase C increases 11beta-hydroxysteroid dehydrogenase oxidation and inhibits reduction in rat Leydig cells. Journal of andrology 20020101
Synthesis, biological activity and molecular modeling studies of 1,2,3,4-tetrahydroisoquinoline derivatives as conformationally constrained analogues of KN62, a potent antagonist of the P2X7-receptor containing a tyrosine moiety. Arzneimittel-Forschung 20020101
Effects of calcium, calmodulin, protein kinase C and protein tyrosine kinases on volume-activated taurine efflux in human erythroleukemia cells. Journal of cellular physiology 20011201
Calmodulin and a cyclic nucleotide-dependent protein kinase facilitate the prolactin-induced increase in tyrosine hydroxylase activity in tuberoinfundibular dopaminergic neurons. Endocrine 20011101
Ameliorative effect of vasopressin-(4-9) through vasopressin V(1A) receptor on scopolamine-induced impairments of rat spatial memory in the eight-arm radial maze. European journal of pharmacology 20010907
Functional characterization of P2Y and P2X receptors in human eosinophils. Journal of cellular physiology 20010901
P2Y(11) receptor expression by human lymphocytes: evidence for two cAMP-linked purinoceptors. European journal of pharmacology 20010831
Complex intracellular messenger pathways regulate one type of neuronal alpha-bungarotoxin-resistant nicotinic acetylcholine receptors expressed in insect neurosecretory cells (dorsal unpaired median neurons). Molecular pharmacology 20010701
Glutamate induces focal adhesion kinase tyrosine phosphorylation and actin rearrangement in heterologous mGluR1-expressing CHO cells via calcium/calmodulin signaling. Journal of neurochemistry 20010701
Histamine production by cultured microglial cells of the mouse. Neuroscience letters 20010615
Stimulation of astrocyte-enriched culture with C2 ceramide increases proenkephalin mRNA: involvement of cAMP-response element binding protein and mitogen activated protein kinases. Brain research 20010608
CAMKII inhibition in the parabrachial nuclei elicits conditioned taste aversion in rats. Neurobiology of learning and memory 20010501
Induction of differentiation of human myeloid leukemia cells by immunosuppressant macrolides (rapamycin and FK506) and calcium/calmodulin-dependent kinase inhibitors. Experimental hematology 20010501
Complexities of measuring antagonist potency at P2X(7) receptor orthologs. The Journal of pharmacology and experimental therapeutics 20010301
Modulation of the neuronal dopamine transporter activity by the metabotropic glutamate receptor mGluR5 in rat striatal synaptosomes through phosphorylation mediated processes. Journal of neurochemistry 20010301
The stimulation of MAP kinase by 1,25(OH)(2)-vitamin D(3) in skeletal muscle cells is mediated by protein kinase C and calcium. Molecular and cellular endocrinology 20010227
Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356. FEBS letters 20010209
The CEACAM1-L Ser503 residue is crucial for inhibition of colon cancer cell tumorigenicity. Oncogene 20010111
Modulation of choline acetyltransferase synthesis by okadaic acid, a phosphatase inhibitor, and KN-62, a CaM kinase inhibitor, in NS-20Y neuroblastoma. Neurochemistry international 20010101
Effects of extracellular calcium and potassium on the sodium pump of rat adrenal glomerulosa cells. American journal of physiology. Cell physiology 20010101
A proposed mechanism for the potentiation of cAMP-mediated acid secretion by carbachol. American journal of physiology. Cell physiology 20010101
Cell cycle phase specificity in the potentiation of etoposide-induced DNA damage and apoptosis by KN-62, an inhibitor of calcium-calmodulin-dependent enzymes. Biochemical pharmacology 20010101
Calmodulin kinases II and IV and calcineurin are involved in leukemia inhibitory factor-induced cardiac hypertrophy in rats. Circulation research 20001110
Estrogen activation of the nuclear orphan receptor CAR (constitutive active receptor) in induction of the mouse Cyp2b10 gene. Molecular endocrinology (Baltimore, Md.) 20001101
Specificity and mechanism of action of some commonly used protein kinase inhibitors. The Biochemical journal 20001001
Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases. Proceedings of the National Academy of Sciences of the United States of America 20000411
MAP kinase-independent induction of proto-oncogene c-fos mRNA by hemin in human cells. Biochemical and biophysical research communications 19990624
Effects of antagonists at the human recombinant P2X7 receptor. British journal of pharmacology 19980701
Differential effects of omega-conotoxin GVIA, nimodipine, calmidazolium and KN-62 injected intrathecally on the antinociception induced by beta-endorphin, morphine and [D-Ala2,N-MePhe4,Gly-ol5]-enkephalin administered intracerebroventricularly in the mouse. The Journal of pharmacology and experimental therapeutics 19970801
The isoquinoline derivative KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes. British journal of pharmacology 19970401
Inhibition of sandfly fever Sicilian virus (Phlebovirus) replication in vitro by antiviral compounds. Research in virology 19970101
KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II. The Journal of biological chemistry 19900315

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