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125314-64-9

125314-64-9 | Carbamimidothioic acid, 3-[3-[2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl ester

CAS No: 125314-64-9 Catalog No: AG000NHG MDL No:

Product Description

Catalog Number:
AG000NHG
Chemical Name:
Carbamimidothioic acid, 3-[3-[2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl ester
CAS Number:
125314-64-9
Molecular Formula:
C25H23N5O2S
Molecular Weight:
457.5474
IUPAC Name:
3-[3-[4-(1-methylindol-3-yl)-2,5-dioxopyrrol-3-yl]indol-1-yl]propyl carbamimidothioate
InChI:
InChI=1S/C25H23N5O2S/c1-29-13-17(15-7-2-4-9-19(15)29)21-22(24(32)28-23(21)31)18-14-30(11-6-12-33-25(26)27)20-10-5-3-8-16(18)20/h2-5,7-10,13-14H,6,11-12H2,1H3,(H3,26,27)(H,28,31,32)
InChI Key:
DSXXEELGXBCYNQ-UHFFFAOYSA-N
SMILES:
NC(=N)SCCCn1cc(c2c1cccc2)C1=C(C(=O)NC1=O)c1cn(c2c1cccc2)C
UNII:
W9A0B5E78O

Properties

Complexity:
845  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
457.157g/mol
Formal Charge:
0
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
457.552g/mol
Monoisotopic Mass:
457.157g/mol
Rotatable Bond Count:
7  
Topological Polar Surface Area:
131A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3  

Literature

Title Journal
Novel Nrf2/ARE activator, trans-Coniferylaldehyde, induces a HO-1-mediated defense mechanism through a dual p38α/MAPKAPK-2 and PK-N3 signaling pathway. Chemical research in toxicology 20150921
The E3 ubiquitin ligase Trim7 mediates c-Jun/AP-1 activation by Ras signalling. Nature communications 20150101
[Protein kinase C mediates thrombin-induced monocyte chemoattractant protein-1 release from human lung fibroblasts]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20120901
Regulation of the alternative splicing of sarcoplasmic reticulum Ca²⁺-ATPase1 (SERCA1) by phorbol 12-myristate 13-acetate (PMA) via a PKC pathway. Biochemical and biophysical research communications 20120629
Regulation of hippocampal long-term potentiation and long-term depression by diacylglycerol kinase ζ. Hippocampus 20120501
MAPK- and PKC/CREB-dependent induction of interleukin-11 by the environmental contaminant formaldehyde in human bronchial epithelial cells. Toxicology 20120206
Characterization of the cellular action of the MSK inhibitor SB-747651A. The Biochemical journal 20120101
[Identification of signal transduction pathway in fresh and vitrified porcine oocytes]. Tsitologiia 20120101
Targeting sphingosine kinase 1 in carcinoma cells decreases proliferation and survival by compromising PKC activity and cytokinesis. PloS one 20120101
Molecular investigation of the effects of lindane in rat hepatocytes: microarray and mechanistic studies. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20111201
Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signaling. The Journal of biological chemistry 20111111
Parathyroid hormone and the regulation of cell cycle in colon adenocarcinoma cells. Biochimica et biophysica acta 20111001
Inhibition of protein kinase C promotes differentiation of neuroblastoma × glioma NG108-15 hybrid cells. The European journal of neuroscience 20111001
All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells: possible involvement of protein kinase C-delta. Journal of leukocyte biology 20110801
Nitric oxide is an activity-dependent regulator of target neuron intrinsic excitability. Neuron 20110728
Submaximal inhibition of protein kinase C restores ADP-induced dense granule secretion in platelets in the presence of Ca2+. The Journal of biological chemistry 20110617
Synthesis and biological activity of splitomicin analogs targeted at human NAD(+)-dependent histone deacetylases (sirtuins). Bioorganic & medicinal chemistry 20110615
PKC and PTPα participate in Src activation by 1α,25OH2 vitamin D3 in C2C12 skeletal muscle cells. Molecular and cellular endocrinology 20110606
SHAFTS: a hybrid approach for 3D molecular similarity calculation. 2. Prospective case study in the discovery of diverse p90 ribosomal S6 protein kinase 2 inhibitors to suppress cell migration. Journal of medicinal chemistry 20110526
Somatic depolarization enhances GABA release in cerebellar interneurons via a calcium/protein kinase C pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience 20110413
Insulin up-regulates heme oxygenase-1 expression in 3T3-L1 adipocytes via PI3-kinase- and PKC-dependent pathways and heme oxygenase-1-associated microRNA downregulation. Endocrinology 20110201
PKC inhibitors RO 31-8220 and Gö 6983 enhance epinephrine-induced platelet aggregation in catecholamine hypo-responsive platelets by enhancing Akt phosphorylation. BMB reports 20110201
Effects of gomisin A on vascular contraction in rat aortic rings. Naunyn-Schmiedeberg's archives of pharmacology 20110101
Differential inhibitor sensitivity between human kinases VRK1 and VRK2. PloS one 20110101
M-CSF induces monocyte survival by activating NF-κB p65 phosphorylation at Ser276 via protein kinase C. PloS one 20110101
Action potential bursts in central snail neurons elicited by paeonol: roles of ionic currents. Acta pharmacologica Sinica 20101201
Expression of CD203c and CD63 in human basophils: relationship to differential regulation of piecemeal and anaphylactic degranulation processes. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20100901
Chitinase induce the release of IL-8 in human airway epithelial cells, via Ca2+-dependent PKC and ERK pathways. Scandinavian journal of immunology 20100701
The ceramide-1-phosphate analogue PCERA-1 modulates tumour necrosis factor-alpha and interleukin-10 production in macrophages via the cAMP-PKA-CREB pathway in a GTP-dependent manner. Immunology 20100301
Novel 3-arylideneindolin-2-ones as inhibitors of NAD+ -dependent histone deacetylases (sirtuins). Journal of medicinal chemistry 20100211
Involvement of phosphatidylcholine-phospholipase C and protein kinase C in peptidoglycan-induced nuclear factor-kappaB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages. Pharmacological research 20100201
Protein kinase C epsilon is involved in ionizing radiation induced bystander response in human cells. The international journal of biochemistry & cell biology 20091201
Nitro-aspirin inhibits MCF-7 breast cancer cell growth: effects on COX-2 expression and Wnt/beta-catenin/TCF-4 signaling. Biochemical pharmacology 20091115
Identification and characterization of novel sirtuin inhibitor scaffolds. Bioorganic & medicinal chemistry 20091001
[Fast nongenomic aldosterone effect on the kinetics of intracellular sodium and cell volume in the cortical part of collecting ducts of the rat kidney]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20090801
Periadventitial adipose tissue impairs coronary endothelial function via PKC-beta-dependent phosphorylation of nitric oxide synthase. American journal of physiology. Heart and circulatory physiology 20090701
Fragment and knowledge-based design of selective GSK-3beta inhibitors using virtual screening models. European journal of medicinal chemistry 20090601
Mechanism of action of the stimulatory effect of apigenin-6-C-(2''-O-alpha-l-rhamnopyranosyl)-beta-L-fucopyranoside on 14C-glucose uptake. Chemico-biological interactions 20090515
The PKC inhibitor Ro31-8220 blocks acute amphetamine-induced dopamine overflow in the nucleus accumbens. Neuroscience letters 20090515
IL-17F-induced IL-11 release in bronchial epithelial cells via MSK1-CREB pathway. American journal of physiology. Lung cellular and molecular physiology 20090501
9-Fluorenylmethoxycarbonyl-labeled peptides as substrates in a capillary electrophoresis-based assay for sirtuin enzymes. Analytical biochemistry 20090415
A role for Rho-kinase in Ca-independent contractions induced by phorbol-12,13-dibutyrate. Clinical and experimental pharmacology & physiology 20090301
Cyclic AMP-dependent protein kinase A and protein kinase C phosphorylate alpha4beta2 nicotinic receptor subunits at distinct stages of receptor formation and maturation. Neuroscience 20090218
Differential roles of MAPKs and MSK1 signalling pathways in the regulation of c-Jun during phenylephrine-induced cardiac myocyte hypertrophy. Molecular and cellular biochemistry 20090201
Obligatory role for phosphatidylinositol 4,5-bisphosphate in activation of native TRPC1 store-operated channels in vascular myocytes. The Journal of physiology 20090201
Involvement of PKC in TPA-potentiated apoptosis induction during hemin-mediated erythroid differentiation in K562 cells. Naunyn-Schmiedeberg's archives of pharmacology 20090101
Effect of protein kinase C and protein kinase A inhibitors on contraction of isolated femoral arteries of SHR and Wistar rats. Physiological research 20090101
Nitric oxide protects the heart from ischemia-induced apoptosis and mitochondrial damage via protein kinase G mediated blockage of permeability transition and cytochrome c release. Journal of biomedical science 20090101
Characterization and regulation of basal calcium influx in human peripheral blood lymphocytes. General physiology and biophysics 20081201
Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity. Journal of cellular biochemistry 20080801
Effect of aldosterone on kinetics of intracellular sodium in cortical portion of collecting ducts in rat kidney. Bulletin of experimental biology and medicine 20080801
Protein kinase C is a common component of CGRP receptor desensitization induced by distinct agonists. European journal of pharmacology 20080610
Differential effects of tumor necrosis factor-alpha and interleukin-1beta on cell death in human articular chondrocytes. Osteoarthritis and cartilage 20080601
Heme oxygenase-1 mediates the anti-inflammatory effect of Curcumin within LPS-stimulated human monocytes. Journal of cellular physiology 20080601
PKC promotes proliferation of airway smooth muscle cells by regulating cyclinD1 expression in asthmatic rats. Acta pharmacologica Sinica 20080601
HTS assays using a disease-relevant cell model for interrogating the MAP kinase pathway initiated by multiple receptors. Assay and drug development technologies 20080601
Host perception and signal transduction studies in wild-type Blumeria graminis f. sp. hordei and a quinoxyfen-resistant mutant implicate quinoxyfen in the inhibition of serine esterase activity. Pest management science 20080501
Protein kinase C inhibitors alter neurotensin receptor binding and function in prostate cancer PC3 cells. Regulatory peptides 20080410
Acrolein induces heme oxygenase-1 through PKC-delta and PI3K in human bronchial epithelial cells. American journal of respiratory cell and molecular biology 20080401
Rho kinase is involved in Ca2+ entry of rat penile small arteries. American journal of physiology. Heart and circulatory physiology 20080401
Multiple mechanisms are involved in 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer cells. Molecular carcinogenesis 20080301
Progress in allergy signal research on mast cells: up-regulation of histamine signal-related gene expression in allergy model rats. Journal of pharmacological sciences 20080301
[Effect of lysophosphatidic acid increase the permeability of blood-brain barrier model]. Zhonghua yi xue za zhi 20080205
Exposure of normal human melanocytes to a tumor promoting phorbol ester reverses growth suppression by transforming growth factor beta. Journal of cellular physiology 20080201
Role of intracellular kinases in the regulation of equine eosinophil migration and actin polymerization. Journal of veterinary pharmacology and therapeutics 20080201
Protein kinase C synergistically stimulates tumor necrosis factor-alpha-induced secretion of urokinase-type plasminogen activator in human dental pulp cells. The journal of physiological sciences : JPS 20080201
The selectivity of protein kinase inhibitors: a further update. The Biochemical journal 20071215
Effect of cigarette smoke extract on proliferation of rat pulmonary artery smooth muscle cells and the relevant roles of protein kinase C. Chinese medical journal 20070905
Modulation of CCK-8-evoked intracellular Ca2+ waves by hydrogen peroxide in mouse pancreatic acinar cells. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20070901
Mechanism of membrane redistribution of protein kinase C by its ATP-competitive inhibitors. The Biochemical journal 20070715
Sensitisation of TRPV1 in rat sensory neurones by activation of SNSRs. Neuroscience letters 20070705
Regulation of the Na+/Ca2+ exchanger (NCX) in the murine embryonic heart. Cardiovascular research 20070701
Inhibition of protein kinase C protects against paraoxon-mediated neuronal cell death. Neurotoxicology 20070701
Heterologous up-regulation of the histamine H1 receptor by M3 muscarinic receptor-mediated activation of H1-receptor gene transcription. The Journal of pharmacy and pharmacology 20070601
Activation of protein kinase Czeta mediates luteinizing hormone- or forskolin-induced NGFI-B expression in preovulatory granulosa cells of rat ovary. Molecular and cellular endocrinology 20070530
Stimulation of histamine H1 receptor up-regulates histamine H1 receptor itself through activation of receptor gene transcription. Journal of pharmacological sciences 20070401
A genomic screen for activators of the antioxidant response element. Proceedings of the National Academy of Sciences of the United States of America 20070320
Effects of arsenic trioxide on the cellular proliferation, apoptosis and differentiation of human neuroblastoma cells. Cancer letters 20070208
Protein kinase D2 mediates lysophosphatidic acid-induced interleukin 8 production in nontransformed human colonic epithelial cells through NF-kappaB. American journal of physiology. Cell physiology 20070201
Protein kinase C activity is required for cytotoxic T cell lytic granule exocytosis, but the theta isoform does not play a preferential role. Journal of leukocyte biology 20070201
Regulation of SR-BI-mediated selective lipid uptake in Chinese hamster ovary-derived cells by protein kinase signaling pathways. Journal of lipid research 20070201
(+/-)3,4-Methylenedioxyamphetamine elicits action potential bursts in a central snail neuron. Experimental neurology 20070201
Evidence that tumor necrosis factor-related apoptosis-inducing ligand induction by 5-Aza-2'-deoxycytidine sensitizes human breast cancer cells to adriamycin. Cancer research 20070201
The inhibition of endocytosis affects HDL-lipid uptake mediated by the human scavenger receptor class B type I. Molecular membrane biology 20070101
Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition. Journal of medicinal chemistry 20061214
Involvement of phosphatidylinositol-phospholipase C in immune response to Salmonella lipopolysacharide in chicken macrophage cells (HD11). International immunopharmacology 20061205
Curcumin inhibits neurotensin-mediated interleukin-8 production and migration of HCT116 human colon cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research 20060915
Inhibitors of the PI3-kinase/Akt pathway induce mitotic catastrophe in non-small cell lung cancer cells. International journal of cancer 20060901
Homology model of RSK2 N-terminal kinase domain, structure-based identification of novel RSK2 inhibitors, and preliminary common pharmacophore. Bioorganic & medicinal chemistry 20060901
Inhibition of protein kinase C epsilon causes ciliated bovine bronchial cell detachment. Experimental lung research 20060901
Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure. Circulation 20060808
P2Y12 receptor signalling towards PKB proceeds through IGF-I receptor cross-talk and requires activation of Src, Pyk2 and Rap1. Cellular signalling 20060801
Acquisition of apoptotic resistance in cadmium-induced malignant transformation: specific perturbation of JNK signal transduction pathway and associated metallothionein overexpression. Molecular carcinogenesis 20060801
Roles of protein kinase C, Ca2+, Pyk2, and c-Src in agonist activation of rat lacrimal gland p42/p44 MAPK. Investigative ophthalmology & visual science 20060801
Zinc is required for Fc epsilon RI-mediated mast cell activation. Journal of immunology (Baltimore, Md. : 1950) 20060715
Enhancement of tumor invasion depends on transdifferentiation of skin fibroblasts mediated by reactive oxygen species. Journal of cell science 20060701
Actin polymerisation regulates thrombin-evoked Ca(2+) signalling after activation of PAR-4 but not PAR-1 in human platelets. Platelets 20060501
Substance P initiates NFAT-dependent gene expression in spinal neurons. Journal of neurochemistry 20060401
Nonclassical action of retinoic acid on the activation of the cAMP response element-binding protein in normal human bronchial epithelial cells. Molecular biology of the cell 20060201
Signalling pathways evoked by alpha1-adrenoceptors in human melanoma cells. Cell biochemistry and function 20060101
Albumin stimulation of eosinophil migration involves PI3-kinases and is associated with diminished eosinophil CD49d and CD49f expression. International archives of allergy and immunology 20060101
Different roles of protein kinase C-betaI and -delta in the regulation of adipocyte differentiation. The international journal of biochemistry & cell biology 20060101
Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase. Journal of medicinal chemistry 20051201
Rho kinase inhibitors reduce neurally evoked contraction of the rat tail artery in vitro. British journal of pharmacology 20051101
Intraplatelet signaling mechanisms of the priming effect of matrix metalloproteinase-2 on platelet aggregation. Journal of thrombosis and haemostasis : JTH 20051101
Native and oxidized low-density lipoproteins stimulate endothelin-converting enzyme-1 expression in human endothelial cells. Biochemical and biophysical research communications 20050902
Interleukin-10 inhibits lipopolysaccharide-induced survival and extracellular signal-regulated kinase activation in human neutrophils. European journal of immunology 20050901
Overexpression of heat-shock protein 20 in rat heart myogenic cells confers protection against simulated ischemia/reperfusion injury. Acta pharmacologica Sinica 20050901
Acute IL-3 priming up-regulates the stimulus-induced Raf-1-Mek-Erk cascade independently of IL-3-induced activation of Erk. Journal of immunology (Baltimore, Md. : 1950) 20050901
Glycogen synthase kinase 3-dependent phosphorylation of Mdm2 regulates p53 abundance. Molecular and cellular biology 20050801
Inhibition of CREB transcriptional activity in human T lymphocytes by oxidative stress. Free radical biology & medicine 20050615
Vitamin C inhibits platelet expression of CD40 ligand. Free radical biology & medicine 20050615
Effects of bisindolylmaleimide PKC inhibitors on p90RSK activity in vitro and in adult ventricular myocytes. British journal of pharmacology 20050601
The cytosolic phospholipase A2 pathway, a safeguard of beta2-adrenergic cardiac effects in rat. The Journal of biological chemistry 20050513
Group I metabotropic glutamate receptors, mGlu1a and mGlu5a, couple to cyclic AMP response element binding protein (CREB) through a common Ca2+ - and protein kinase C-dependent pathway. Journal of neurochemistry 20050401
Effect of GLP-1 on glucose transport and its cell signalling in human myocytes. Regulatory peptides 20050330
The role of protein kinase C in regulating equine eosinophil adherence and superoxide production. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20050301
Mechanisms of desensitization of the adrenocorticotropin response to arginine vasopressin in ovine anterior pituitary cells. The Journal of endocrinology 20050101
The synthetic chemoattractant peptide WKYMVm induces superoxide production by human eosinophils via the phosphoinositide 3-kinase-mediated activation of ERK1/2. International archives of allergy and immunology 20050101
[Effects of guanine nucleotides and protein kinase C on prolactin-stimulated release of Ca from intracellular stores of pig oocytes]. Ontogenez 20050101
Massive augmentation of stimulated insulin secretion induced by fatty acid-free BSA in rat pancreatic islets. Diabetes 20041201
Transcriptional up-regulation in expression of 5-hydroxytryptamine2A and transcriptional down-regulation of angiotensin II type 1 receptors during organ culture of rat mesenteric artery. Basic & clinical pharmacology & toxicology 20041201
A novel Ca2+-independent signaling pathway to extracellular signal-regulated protein kinase by coactivation of NMDA receptors and metabotropic glutamate receptor 5 in neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 20041201
Specificity of action of bisindolylmaleimide protein kinase C inhibitors: do they inhibit the 70kDa ribosomal S6 kinase in cardiac myocytes? Biochemical pharmacology 20041115
IL-10 production induced by HIV-1 Tat stimulation of human monocytes is dependent on the activation of PKC beta(II) and delta isozymes. Microbes and infection 20041101
Mechanisms of mitogen-activated protein kinase inhibition by parathyroid hormone in osteoblast-like cells. Journal of the American Society of Nephrology : JASN 20041101
Phenylephrine induces activation of CREB in adult rat cardiac myocytes through MSK1 and PKA signaling pathways. Journal of molecular and cellular cardiology 20041101
Regulation of beta1 integrin expression by PKCepsilon in renal cancer cells. International journal of oncology 20041001
Inhibition of human immunodeficiency virus type 1 replication by Z-100, an immunomodulator extracted from human-type tubercle bacilli, in macrophages. The Journal of general virology 20040901
Protein kinase Calpha translocates to the perinuclear region to activate phospholipase D1. The Journal of biological chemistry 20040820
Identifying pathways involved in leptin-dependent aggregation of human platelets. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 20040801
Inhibition of MKP-1 expression potentiates JNK related apoptosis in renal cancer cells. The Journal of urology 20040801
Histamine H1 receptor down-regulation mediated by M3 muscarinic acetylcholine receptor subtype. Journal of pharmacological sciences 20040801
ATP priming of macrophage-derived chemokine responses in CHO cells expressing the CCR4 receptor. Naunyn-Schmiedeberg's archives of pharmacology 20040701
Interleukin-1beta stimulates matrix metalloproteinase-2 expression via a prostaglandin E2-dependent mechanism in human chondrocytes. Experimental & molecular medicine 20040630
Potent activation of multiple signalling pathways by C-peptide in opossum kidney proximal tubular cells. Diabetologia 20040601
Regulation of phospholipase D2 activity by protein kinase C alpha. The Journal of biological chemistry 20040521
Inhibitors of protein kinase C (PKC) prevent activated transcription: role of events downstream of NF-kappaB DNA binding. The Journal of biological chemistry 20040430
gp91phox-containing NADPH oxidase mediates endothelial dysfunction in renovascular hypertension. Circulation 20040413
Mechanisms of action of melanin-concentrating hormone in the teleost fish erythrophoroma cell line (GEM-81). General and comparative endocrinology 20040401
The role of calcium, calcium-activated K+ channels, and tyrosine/kinase in psoralen-evoked responses in human melanoma cells. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20040401
Cell signalling of glucagon-like peptide-1 action in rat skeletal muscle. The Journal of endocrinology 20040301
Phosphatidylinositol 3-kinase activation is required for sulfonylurea stimulation of glucose transport in rat skeletal muscle. Endocrinology 20040201
Stimulation of CD36 and the key effector of reverse cholesterol transport ATP-binding cassette A1 in monocytoid cells by niacin. Biochemical pharmacology 20040201
Modulation of histamine-induced Ca2+ release by protein kinase C. Effects on cytosolic and mitochondrial [Ca2+] peaks. The Journal of biological chemistry 20031212
Phorbol esters and adenosine affect the readily releasable neurotransmitter pool by different mechanisms at amphibian motor nerve endings. The Journal of physiology 20031201
Differential implication of protein kinase C isoforms in cytotoxic T lymphocyte degranulation and TCR-induced Fas ligand expression. International immunology 20031201
The role of rho and rho-dependent kinase in serotonin-induced contraction observed in bovine middle cerebral artery. The Tohoku journal of experimental medicine 20031201
Protein kinase C (PKC) isotype profile in eosinophils from ponies with sweet itch and role in histamine-induced eosinophil activation. Veterinary immunology and immunopathology 20031115
Regulated cell surface pro-EGF ectodomain shedding is a zinc metalloprotease-dependent process. The Journal of biological chemistry 20031114
Rapid agonist-evoked coupling of type II Ins(1,4,5)P3 receptor with human transient receptor potential (hTRPC1) channels in human platelets. The Biochemical journal 20031101
Mitogenic effects of phospholipase D and phosphatidic acid in transiently permeabilized astrocytes: effects of ethanol. Journal of neurochemistry 20031001
Arsenite stimulated glucose transport in 3T3-L1 adipocytes involves both Glut4 translocation and p38 MAPK activity. European journal of biochemistry 20031001
Amlodipine activates the endothelial nitric oxide synthase by altering phosphorylation on Ser1177 and Thr495. Cardiovascular research 20031001
Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes. Circulation research 20030822
C-terminal fragment of tetanus toxin heavy chain activates Akt and MEK/ERK signalling pathways in a Trk receptor-dependent manner in cultured cortical neurons. The Biochemical journal 20030715
Inhibition of protein kinase CbetaII increases glucose uptake in 3T3-L1 adipocytes through elevated expression of glucose transporter 1 at the plasma membrane. Molecular endocrinology (Baltimore, Md.) 20030701
Variations in cell signaling pathways for different vasoconstrictor agonists in renal circulation of the rat. Kidney international 20030601
Unique T cell proliferation associated with PKCmu activation and impaired ZAP-70 phosphorylation in recognition of overexpressed HLA/partially agonistic peptide complexes. European journal of immunology 20030601
Inhibition of histamine H1 receptor downregulation by KT5823, a protein kinase G inhibitor. Methods and findings in experimental and clinical pharmacology 20030601
Phosphorylation of the alpha4 subunit of human alpha4beta2 nicotinic receptors: role of cAMP-dependent protein kinase (PKA) and protein kinase C (PKC). Brain research. Molecular brain research 20030526
Distinct protein kinase C isoforms mediate regulation of vascular endothelial growth factor expression by A2A adenosine receptor activation and phorbol esters in pheochromocytoma PC12 cells. The Journal of biological chemistry 20030425
[Effect of protein kinase C on K(V) channel in rat bronchial smooth muscle]. Sheng li xue bao : [Acta physiologica Sinica] 20030425
Activation of protein kinase C inhibits retrograde transport of neurotrophins in mice. Journal of neuroscience research 20030415
Kinase inhibitors: not just for kinases anymore. Journal of medicinal chemistry 20030410
Effect of the lipid peroxidation product acrolein on tau phosphorylation in neural cells. Journal of neuroscience research 20030315
Lithium inhibits a late step in agrin-induced AChR aggregation. Journal of neurobiology 20030205
Essential role of rho kinase in the Ca2+ sensitization of prostaglandin F(2alpha)-induced contraction of rabbit aortae. The Journal of physiology 20030201
Thrombin rapidly induces protein kinase D phosphorylation, and protein kinase C delta mediates the activation. The Journal of biological chemistry 20030131
Activation of RAF-1 through Ras and protein kinase Calpha mediates 1alpha,25(OH)2-vitamin D3 regulation of the mitogen-activated protein kinase pathway in muscle cells. The Journal of biological chemistry 20030124
Negative regulation of phosphatidylinositol 3-kinase and Akt signalling pathway by PKC. Cellular signalling 20030101
Rho-kinase inhibition blunts renal vasoconstriction induced by distinct signaling pathways in vivo. Journal of the American Society of Nephrology : JASN 20030101
The involvement of lipid activators of protein kinase C in the induction of ZIF268 in PC12 cells exposed to lead. Neurochemical research 20030101
Endothelial NADPH oxidase: mechanism of activation by low-density lipoprotein. Endothelium : journal of endothelial cell research 20030101
Ca2+-stimulated Ca2+ oscillations produced by the Ca2+-sensing receptor require negative feedback by protein kinase C. The Journal of biological chemistry 20021206
Protein kinase C- and calcium-regulated pathways independently synergize with Gi pathways in agonist-induced fibrinogen receptor activation. The Biochemical journal 20021201
alpha1B-Adrenergic receptor phosphorylation and desensitization induced by transforming growth factor-beta. The Biochemical journal 20021201
Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: role of PI3K, PKC and PLC pathways. British journal of pharmacology 20021201
Interleukin-1beta induces MUC2 gene expression and mucin secretion via activation of PKC-MEK/ERK, and PI3K in human airway epithelial cells. Journal of Korean medical science 20021201
Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein. The Biochemical journal 20021115
Regulation of follistatin-related gene (FLRG) expression by protein kinase C and prostaglandin E(2) in cultured granulosa-luteal cells. Molecular human reproduction 20021101
PGD(2) modulates fibroblast-mediated native collagen gel contraction. American journal of respiratory cell and molecular biology 20020901
Failure to activate caspase 3 in phorbol ester-resistant leukemia cells is associated with resistance to apoptotic cell death. Cancer letters 20020828
The role of calcium in oligogalacturonide-activated signalling in soybean cells. Planta 20020801
Superoxide anion-dependent Raf/MEK/ERK activation by peroxisome proliferator activated receptor gamma agonists 15-deoxy-delta(12,14)-prostaglandin J(2), ciglitazone, and GW1929. Experimental cell research 20020715
Impaired protein kinase C activation/translocation in Epstein-Barr virus-infected monocytes. The Journal of biological chemistry 20020705
Different actions of protein kinase C isoforms alpha and epsilon on gastric acid secretion. British journal of pharmacology 20020701
Exendin-4 as a stimulator of rat insulin I gene promoter activity via bZIP/CRE interactions sensitive to serine/threonine protein kinase inhibitor Ro 31-8220. Endocrinology 20020601
Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling. FEBS letters 20020522
Involvement of protein kinase D in Fc gamma-receptor activation of the NADPH oxidase in neutrophils. The Biochemical journal 20020401
Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor. Journal of neurochemistry 20020401
Phorbol esters inhibit fibroblast growth factor-2-stimulated fibroblast proliferation by a p38 MAP kinase dependent pathway. Oncogene 20020327
Phosphorylation-dependent regulation of phospholipase D2 by protein kinase C delta in rat Pheochromocytoma PC12 cells. The Journal of biological chemistry 20020308
Regulation of cyclooxygenase-2 expression by phospholipase D in human amnion-derived WISH cells. Molecular pharmacology 20020301
Protein kinase D is a downstream target of protein kinase Ctheta. Biochemical and biophysical research communications 20020301
Protein phosphatase 2A and protein kinase Calpha are physically associated and are involved in Pseudomonas aeruginosa-induced interleukin 6 production by mast cells. The Journal of biological chemistry 20020215
Over-expression of the glucagon-like peptide-1 receptor on INS-1 cells confers autocrine stimulation of insulin gene promoter activity: a strategy for production of pancreatic beta-cell lines for use in transplantation. Cell and tissue research 20020201
The cytoplasmic tail of L-selectin interacts with members of the Ezrin-Radixin-Moesin (ERM) family of proteins: cell activation-dependent binding of Moesin but not Ezrin. The Journal of biological chemistry 20020118
Protein kinase C epsilon mediates the induction of P-glycoprotein in LNCaP prostate carcinoma cells. Cellular signalling 20020101
Acquisition of apoptotic resistance in arsenic-induced malignant transformation: role of the JNK signal transduction pathway. Carcinogenesis 20020101
Selective induction of mitogen-activated protein kinases in human lens epithelial cells by ultraviolet radiation. Journal of biochemical and molecular toxicology 20020101
[Involvement of protein kinase C in the regulation of Ca2+ exit from intracellular stores of prolactin stimulated pig oocytes]. Tsitologiia 20020101
Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-beta1 in human breast cancer cells. Oncogene 20011206
Regulation of SP-B and SP-C secretion in rat type II cells in primary culture. American journal of physiology. Lung cellular and molecular physiology 20011201
Synergistic effect of urotensin II with serotonin on vascular smooth muscle cell proliferation. Journal of hypertension 20011201
Signalling components underlying platelet aggregation to a Ca2+ ionophore and a phorbol ester. Platelets 20011201
Phosphorylation is involved in the activation of metal-regulatory transcription factor 1 in response to metal ions. The Journal of biological chemistry 20011109
Characterisation of Rac activation in thrombin- and collagen-stimulated human blood platelets. FEBS letters 20011102
Nuclear factor-kappa B augments beta(2)-adrenergic receptor expression in human airway epithelial cells. American journal of physiology. Lung cellular and molecular physiology 20011101
Transcription activator protein 1 (AP-1) mediates NO-induced apoptosis of adult cardiomyocytes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20011101
PKC- and ERK-dependent activation of I kappa B kinase by lipopolysaccharide in macrophages: enhancement by P2Y receptor-mediated CaMK activation. British journal of pharmacology 20011101
Effects of homocysteine on murine splenic B lymphocyte proliferation and its signal transduction mechanism. Cardiovascular research 20011101
Activation of protein kinase D by signaling through Rho and the alpha subunit of the heterotrimeric G protein G13. The Journal of biological chemistry 20011019
Regulation of phospholipase D isoenzymes by transforming Ras and atypical protein kinase C-iota. The Biochemical journal 20011001
Signalling events underlying platelet aggregation induced by the glycoprotein VI agonist convulxin. European journal of biochemistry 20011001
Pharmacological comparison of LTB(4)-induced NADPH oxidase activation in adherent and non-adherent guinea-pig eosinophils. British journal of pharmacology 20011001
[A study of the effect of protein kinase C on the expression of nitric oxide synthase mRNA in pulmonary artery smooth muscle in hypoxia]. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20011001
Gene expression profile in BALB/c-3T3 cells transformed with beryllium sulfate. Molecular carcinogenesis 20010901
Inotropic actions of protein kinase C activation by phorbol dibutyrate in guinea-pig isolated ventricular myocytes. Experimental physiology 20010901
Differences in functional consequences and signal transduction induced by IL-3, IL-5, and nerve growth factor in human basophils. Journal of immunology (Baltimore, Md. : 1950) 20010815
Histamine-induced vasoconstriction involves phosphorylation of a specific inhibitor protein for myosin phosphatase by protein kinase C alpha and delta isoforms. The Journal of biological chemistry 20010803
beta-estradiol stimulation of DNA synthesis requires different PKC isoforms in HepG2 and MCF7 cells. Journal of cellular physiology 20010801
Oxidized low-density lipoprotein downregulates endothelial basic fibroblast growth factor through a pertussis toxin-sensitive G-protein pathway: mediator role of platelet-activating factor-like phospholipids. Circulation 20010731
Actions of arachidonic acid on contractions and associated electrical activity in guinea-pig isolated ventricular myocytes. Experimental physiology 20010701
Hyaluronan fragments induce the synthesis of MCP-1 and IL-8 in cultured human peritoneal mesothelial cells. Cell and tissue research 20010701
Sustained norepinephrine stimulation induces different regulation of expression in three alpha1-adrenoceptor subtypes. Life sciences 20010608
Cadmium-induced cell transformation and tumorigenesis are associated with transcriptional activation of c-fos, c-jun, and c-myc proto-oncogenes: role of cellular calcium and reactive oxygen species. Toxicological sciences : an official journal of the Society of Toxicology 20010601
Oxytocin stimulates prostaglandin F2alpha secretion from porcine endometrial cells through activation of calcium-dependent protein kinase C. Prostaglandins & other lipid mediators 20010601
Effect of protein kinase C activation on the glycine evoked Cl(-) current in spinal cord neurons. Brain research 20010525
Extracellular ATP stimulates an inhibitory pathway towards growth factor-induced cRaf-1 and MEKK activation in astrocyte cultures. Journal of neurochemistry 20010501
Hypoxic enhancement of evoked noradrenaline release from the human neuroblastoma SH-SY5Y. Brain research. Molecular brain research 20010418
Hypoxia induces the release of a pulmonary-selective, Ca(2+)-sensitising, vasoconstrictor from the perfused rat lung. Cardiovascular research 20010401
Signalling pathways regulating the dephosphorylation of Ser729 in the hydrophobic domain of protein kinase Cepsilon upon cell passage. The Journal of biological chemistry 20010330
Lipid peroxidation product 4-hydroxy-2-nonenal acts synergistically with serotonin in inducing vascular smooth muscle cell proliferation. Atherosclerosis 20010301
Modulation of the neuronal dopamine transporter activity by the metabotropic glutamate receptor mGluR5 in rat striatal synaptosomes through phosphorylation mediated processes. Journal of neurochemistry 20010301
Signaling mechanism underlying COX-2 induction by lysophosphatidylcholine. Biochemical and biophysical research communications 20010301
Integrin-independent tyrosine phosphorylation of p125(fak) in human platelets stimulated by collagen. The Journal of biological chemistry 20010202
Vascular endothelial growth factor enhances the expression of urokinase receptor in human endothelial cells via protein kinase C activation. Thrombosis and haemostasis 20010201
p53-independent elevation of p21 expression by PMA results from PKC-mediated mRNA stabilization. Biochemical and biophysical research communications 20010112
Selective secretion of protein kinase C isozymes by thrombin-stimulated human platelets. Biochemical and biophysical research communications 20010112
Ceramide binds to the CaLB domain of cytosolic phospholipase A2 and facilitates its membrane docking and arachidonic acid release. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010101
Bradykinin induces protein kinase C-dependent activation of phospholipase D in A-431 cells. IUBMB life 20010101
Monocyte chemotactic protein 1 amplifies serotonin-induced vascular smooth muscle cell proliferation. Journal of vascular research 20010101
[Effect of elastin peptides on the production of matrix metalloproteinase 2 by human skin fibroblasts in culture]. Journal de la Societe de biologie 20010101
Specificity and mechanism of action of some commonly used protein kinase inhibitors. The Biochemical journal 20001001
ERK signaling mediates the induction of inflammatory cytokines by bufalin in human monocytic cells. American journal of physiology. Cell physiology 20000301
Protein phosphatase-protein kinase interplay modulates alpha 1b-adrenoceptor phosphorylation: effects of okadaic acid. British journal of pharmacology 20000201
Studies on the mechanism of fibrate-inhibited expression of plasminogen activator inhibitor-1 in cultured hepatocytes from cynomolgus monkey. Arteriosclerosis, thrombosis, and vascular biology 19970101
Differential inhibition of cytosolic and membrane-derived protein kinase C activity by staurosporine and other kinase inhibitors. FEBS letters 19950403
Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. The Biochemical journal 19930901

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