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125313-65-7 | 1H-Pyrrole-2,5-dione, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-
CAS No: 125313-65-7 Catalog No: AG000NHK MDL No:
Product Description
Catalog Number:
AG000NHK
Chemical Name:
1H-Pyrrole-2,5-dione, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-
CAS Number:
125313-65-7
Molecular Formula:
C24H22N4O2
Molecular Weight:
398.4571
IUPAC Name:
3-[1-(3-aminopropyl)indol-3-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione
InChI:
InChI=1S/C24H22N4O2/c1-27-13-17(15-7-2-4-9-19(15)27)21-22(24(30)26-23(21)29)18-14-28(12-6-11-25)20-10-5-3-8-16(18)20/h2-5,7-10,13-14H,6,11-12,25H2,1H3,(H,26,29,30)
InChI Key:
UQHKJRCFSLMWIA-UHFFFAOYSA-N
SMILES:
NCCCn1cc(c2c1cccc2)C1=C(C(=O)NC1=O)c1cn(c2c1cccc2)C
UNII:
Y6197FQK8I
Properties
Complexity:
735
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
398.174g/mol
Formal Charge:
0
Heavy Atom Count:
30
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
398.466g/mol
Monoisotopic Mass:
398.174g/mol
Rotatable Bond Count:
5
Topological Polar Surface Area:
82A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.1
Literature
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| Aryl-indolyl maleimides as inhibitors of CaMKIIdelta. Part 2: SAR of the amine tether. | Bioorganic & medicinal chemistry letters 20080401 |
| Rottlerin causes pulmonary edema in vivo: a possible role for PKCdelta. | Journal of applied physiology (Bethesda, Md. : 1985) 20071201 |
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| Mass-tag technology responding to intracellular signals as a novel assay system for the diagnosis of tumor. | Journal of the American Society for Mass Spectrometry 20070101 |
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| Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase. | Journal of medicinal chemistry 20051201 |
| Different signaling pathways involved in glucose- and cell swelling-induced insulin secretion by rat pancreatic islets in vitro. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20050101 |
| Induction of C-X-C chemokines, growth-related oncogene alpha expression, and epithelial cell-derived neutrophil-activating protein-78 by ML-1 (interleukin-17F) involves activation of Raf1-mitogen-activated protein kinase kinase-extracellular signal-regulated kinase 1/2 pathway. | The Journal of pharmacology and experimental therapeutics 20031201 |
| Negative regulation of phosphatidylinositol 3-kinase and Akt signalling pathway by PKC. | Cellular signalling 20030101 |
| Protein kinase mediated upregulation of endothelin A, endothelin B and 5-hydroxytryptamine 1B/1D receptors during organ culture in rat basilar artery. | British journal of pharmacology 20020901 |
| Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways. | The Journal of biological chemistry 20020809 |
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| Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. | The Biochemical journal 19930901 |
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