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12505-67-8 | 2,4,6,8,9,10-Hexaoxa-1,3,5,7-tetraarsatricyclo[3.3.1.13,7]decane
CAS No: 12505-67-8 Catalog No: AG000N20 MDL No:
Product Description
Catalog Number:
AG000N20
Chemical Name:
2,4,6,8,9,10-Hexaoxa-1,3,5,7-tetraarsatricyclo[3.3.1.13,7]decane
CAS Number:
12505-67-8
Molecular Formula:
As4O6
Molecular Weight:
395.6828
IUPAC Name:
2,4,6,8,9,10-hexaoxa-1,3,5,7-tetrarsatricyclo[3.3.1.13,7]decane
InChI:
InChI=1S/As4O6/c5-1-6-3-8-2(5)9-4(7-1)10-3
InChI Key:
KTTMEOWBIWLMSE-UHFFFAOYSA-N
SMILES:
O1[As]2O[As]3O[As]1O[As](O2)O3
NSC Number:
759274
Properties
Complexity:
84.8
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
395.656g/mol
Formal Charge:
0
Heavy Atom Count:
10
Hydrogen Bond Acceptor Count:
6
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
395.68g/mol
Monoisotopic Mass:
395.656g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
55.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Effect of subchronic exposure to inorganic arsenic on the structure and function of the intestinal epithelium. | Toxicology letters 20180401 |
| (-)-Epicatechin rescues the As(2) O(3) -induced HERG K(+) channel deficiency possibly through upregulating transcription factor SP1 expression. | Journal of biochemical and molecular toxicology 20171101 |
| Assessment of arsenic trioxide toxicity on cock muscular tissue: alterations of oxidative damage parameters, inflammatory cytokines and heat shock proteins. | Ecotoxicology (London, England) 20171001 |
| Inhibition of nicotinamide phosphoribosyltransferase and depletion of nicotinamide adenine dinucleotide contribute to arsenic trioxide suppression of oral squamous cell carcinoma. | Toxicology and applied pharmacology 20170915 |
| Mechanism of As2O3-Induced Action Potential Prolongation and Using hiPS-CMs to Evaluate the Rescue Efficacy of Drugs With Different Rescue Mechanism. | Toxicological sciences : an official journal of the Society of Toxicology 20170801 |
| Chrysin and silibinin sensitize human glioblastoma cells for arsenic trioxide. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170701 |
| Studies on curative efficacy of monoterpene eugenol on anti- leukemic drug arsenic trioxide induced cardiotoxicity. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20170701 |
| Subchronic arsenism-induced oxidative stress and inflammation contribute to apoptosis through mitochondrial and death receptor dependent pathways in chicken immune organs. | Oncotarget 20170620 |
| Survivin isoform expression in arsenic trioxide-treated acute promyelocytic leukemia cell line and patients: The odd expression pattern of survivin-2α. | Asia-Pacific journal of clinical oncology 20170401 |
| Arsenic trioxide targets MTHFD1 and SUMO-dependent nuclear de novo thymidylate biosynthesis. | Proceedings of the National Academy of Sciences of the United States of America 20170321 |
| Activation of the Nrf2 Signaling Pathway Involving KLF9 Plays a Critical Role in Allicin Resisting Against Arsenic Trioxide-Induced Hepatotoxicity in Rats. | Biological trace element research 20170301 |
| Protective effects of oxymatrine against arsenic trioxide-induced liver injury. | Oncotarget 20170221 |
| Assessment of arsenic trioxide in the heart of Gallus gallus: alterations of oxidative damage parameters, inflammatory cytokines, and cardiac enzymes. | Environmental science and pollution research international 20170201 |
| Arsenic and fluoride induce apoptosis, inflammation and oxidative stress in cultured human umbilical vein endothelial cells. | Chemosphere 20170101 |
| Salvianolic Acid A Protects H9c2 Cells from Arsenic Trioxide-Induced Injury via Inhibition of the MAPK Signaling Pathway. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20170101 |
| Inhibition of early T cell cytokine production by arsenic trioxide occurs independently of Nrf2. | PloS one 20170101 |
| Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. | Oncotarget 20161213 |
| microRNA-539 suppresses tumor growth and tumorigenesis and overcomes arsenic trioxide resistance in hepatocellular carcinoma. | Life sciences 20161201 |
| Low dose of arsenic trioxide inhibits multidrug resistant-related P-glycoprotein expression in human neuroblastoma cell line. | International journal of oncology 20161201 |
| Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression. | Oncotarget 20161129 |
| ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosis. | Archives of biochemistry and biophysics 20161101 |
| Differential expression and response to arsenic stress of MRPs and ASAN1 determine sensitivity of classical multidrug-resistant leukemia cells to arsenic trioxide. | Leukemia research 20161101 |
| Combination effects of arsenic trioxide and fibroblast growth factor receptor inhibitor in squamous cell lung carcinoma. | Lung cancer (Amsterdam, Netherlands) 20161101 |
| [Influence of HMGB1/MAPK/m-TOR signaling pathway on cell autophagy and chemotherapy resistance in K562 cells]. | Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20161028 |
| Arsenic trioxide suppresses liver X receptor β and enhances cholesteryl ester transfer protein expression without affecting the liver X receptor α in HepG2 cells. | Chemico-biological interactions 20161025 |
| Activating transcription factor 4 underlies the pathogenesis of arsenic trioxide-mediated impairment of macrophage innate immune functions. | Toxicology and applied pharmacology 20161001 |
| Osteoblasts activate the Nrf2 signalling pathway in response to arsenic trioxide treatment. | The international journal of biochemistry & cell biology 20161001 |
| [Synergistic Inhibitory Effect of Arsenic Trioxide Combined with Itraconazole on Hedgehog Pathway of Multiple Myeloma NCI-H929 Cells]. | Zhongguo shi yan xue ye xue za zhi 20161001 |
| Environmentally relevant concentration of arsenic trioxide and humic acid promoted tumor progression of human cervical cancer cells: In vivo and in vitro studies. | Environmental toxicology 20160901 |
| Curcumin reduces the expression of survivin, leading to enhancement of arsenic trioxide-induced apoptosis in myelodysplastic syndrome and leukemia stem-like cells. | Oncology reports 20160901 |
| Chemosensitivity enhancement toward arsenic trioxide by inhibition of histone deacetylase in NB4 cell line. | The Journal of international medical research 20160801 |
| Arsenic trioxide mediates HAPI microglia inflammatory response and subsequent neuron apoptosis through p38/JNK MAPK/STAT3 pathway. | Toxicology and applied pharmacology 20160715 |
| Mitophagy inhibits proliferation by decreasing cyclooxygenase-2 (COX-2) in arsenic trioxide-treated HepG2 cells. | Environmental toxicology and pharmacology 20160701 |
| Lutein alleviates arsenic-induced reproductive toxicity in male mice via Nrf2 signaling. | Human & experimental toxicology 20160501 |
| EZH2 mediates ATO-induced apoptosis in acute myeloid leukemia cell lines through the Wnt signaling pathway. | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20160501 |
| Arsenic trioxide augments all-trans retinoic acid-induced differentiation of HL-60 cells. | Life sciences 20160315 |
| Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. | Environmental toxicology 20160301 |
| Mutations affecting both the rearranged and the unrearranged PML alleles in refractory acute promyelocytic leukaemia. | British journal of haematology 20160301 |
| ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction underlie apoptosis induced by resveratrol and arsenic trioxide in A549 cells. | Chemico-biological interactions 20160205 |
| Arsenic Trioxide Induces Apoptosis and Incapacitates Proliferation and Invasive Properties of U87MG Glioblastoma Cells through a Possible NF-κB-Mediated Mechanism. | Asian Pacific journal of cancer prevention : APJCP 20160101 |
| Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic. | Proceedings of the National Academy of Sciences of the United States of America 20151208 |
| Promyelocytic leukemia protein induces arsenic trioxide resistance through regulation of aldehyde dehydrogenase 3 family member A1 in hepatocellular carcinoma. | Cancer letters 20150928 |
| Bortezomib and Arsenic Trioxide Activity on a Myelodysplastic Cell Line (P39): A Gene Expression Study. | Turkish journal of haematology : official journal of Turkish Society of Haematology 20150901 |
| Analysis of the transcriptional regulation of cancer-related genes by aberrant DNA methylation of the cis-regulation sites in the promoter region during hepatocyte carcinogenesis caused by arsenic. | Oncotarget 20150828 |
| The mechanism of synergistic effects of arsenic trioxide and rapamycin in acute myeloid leukemia cell lines lacking typical t(15;17) translocation. | International journal of hematology 20150701 |
| Synergistic effects of valproic acid and arsenic trioxide on RPMI8226 cells in vitro and the possible underlying mechanisms. | Molecular medicine reports 20150701 |
| Arsenic trioxide binding to serum proteins. | Journal of photochemistry and photobiology. B, Biology 20150701 |
| Pure total flavonoids from Citrus paradisi Macfadyen act synergistically with arsenic trioxide in inducing apoptosis of Kasumi-1 leukemia cells in vitro. | Journal of Zhejiang University. Science. B 20150701 |
| SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML. | Science signaling 20150609 |
| Up-regulation of miR-21 and miR-23a Contributes to As2 O3 -induced hERG Channel Deficiency. | Basic & clinical pharmacology & toxicology 20150601 |
| Evaluation of gene expression changes in human primary lung epithelial cells following 24-hr exposures to inorganic arsenic and its methylated metabolites and to arsenic trioxide. | Environmental and molecular mutagenesis 20150601 |
| The role of NF-κB in PARP-inhibitor-mediated sensitization and detoxification of arsenic trioxide in hepatocellular carcinoma cells. | The Journal of toxicological sciences 20150601 |
| Mutations of Epigenetic Modifier Genes as a Poor Prognostic Factor in Acute Promyelocytic Leukemia Under Treatment With All-Trans Retinoic Acid and Arsenic Trioxide. | EBioMedicine 20150601 |
| TG-interacting factor transcriptionally induced by AKT/FOXO3A is a negative regulator that antagonizes arsenic trioxide-induced cancer cell apoptosis. | Toxicology and applied pharmacology 20150515 |
| E2F1-mediated FOS induction in arsenic trioxide-induced cellular transformation: effects of global H3K9 hypoacetylation and promoter-specific hyperacetylation in vitro. | Environmental health perspectives 20150501 |
| Arsenic trioxide and reduced glutathione act synergistically to augment inhibition of thyroid peroxidase activity in vitro. | Biological trace element research 20150501 |
| Arsenic trioxide potentiates the anti-cancer activities of sorafenib against hepatocellular carcinoma by inhibiting Akt activation. | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20150401 |
| β-Carotene ameliorates arsenic-induced toxicity in albino mice. | Biological trace element research 20150401 |
| Arsenic trioxide induces programmed cell death through stimulation of ER stress and inhibition of the ubiquitin-proteasome system in human sarcoma cells. | Cancer letters 20150128 |
| PARP-1 inhibitor sensitizes arsenic trioxide in hepatocellular carcinoma cells via abrogation of G2/M checkpoint and suppression of DNA damage repair. | Chemico-biological interactions 20150125 |
| Arsenic trioxide suppresses transcription of hTERT through down-regulation of multiple transcription factors in HL-60 leukemia cells. | Toxicology letters 20150122 |
| Arsenic trioxide inhibits DNA methyltransferase and restores TMS1 gene expression in K562 cells. | Acta haematologica 20150101 |
| Inhibition of the cancer stem cells-like properties by arsenic trioxide, involved in the attenuation of endogenous transforming growth factor beta signal. | Toxicological sciences : an official journal of the Society of Toxicology 20150101 |
| Downregulation of thymidylate synthase and E2F1 by arsenic trioxide in mesothelioma. | International journal of oncology 20150101 |
| Lutein has a protective effect on hepatotoxicity induced by arsenic via Nrf2 signaling. | BioMed research international 20150101 |
| Azacytidine sensitizes acute myeloid leukemia cells to arsenic trioxide by up-regulating the arsenic transporter aquaglyceroporin 9. | Journal of hematology & oncology 20150101 |
| ANXA1 silencing increases the sensitivity of cancer cells to low-concentration arsenic trioxide treatment by inhibiting ERK MAPK activation. | Tumori 20150101 |
| Tetraarsenictetrasulfide and Arsenic Trioxide Exert Synergistic Effects on Induction of Apoptosis and Differentiation in Acute Promyelocytic Leukemia Cells. | PloS one 20150101 |
| Arsenic Trioxide Activate Transcription of Heme Oxygenase-1 by Promoting Nuclear Translocation of NFE2L2. | International journal of medical sciences 20150101 |
| Arsenic trioxide inhibits CXCR4-mediated metastasis by interfering miR-520h/PP2A/NF-κB signaling in cervical cancer. | Annals of surgical oncology 20141201 |
| Tetraarsenic oxide-induced inhibition of malignant glioma cell invasion in vitro via a decrease in matrix metalloproteinase secretion and protein kinase B phosphorylation. | Journal of neurosurgery 20141201 |
| Synergism of arsenic trioxide and MG132 in Raji cells attained by targeting BNIP3, autophagy, and mitochondria with low doses of valproic acid and vincristine. | European journal of cancer (Oxford, England : 1990) 20141201 |
| Inhibition of TGF-β/SMAD3/NF-κB signaling by microRNA-491 is involved in arsenic trioxide-induced anti-angiogenesis in hepatocellular carcinoma cells. | Toxicology letters 20141118 |
| Toward a therapeutic reduction of imatinib refractory myeloproliferative neoplasm-initiating cells. | Oncogene 20141113 |
| Arsenic exposure disrupts the normal function of the FA/BRCA repair pathway. | Toxicological sciences : an official journal of the Society of Toxicology 20141101 |
| The rescuable function and mechanism of resveratrol on As₂O₃-induced hERG K⁺ channel deficiency. | Naunyn-Schmiedeberg's archives of pharmacology 20141101 |
| E2F1 downregulation by arsenic trioxide in lung adenocarcinoma. | International journal of oncology 20141101 |
| Arsenic trioxide induces autophagy and antitumor effects in Burkitt's lymphoma Raji cells. | Oncology reports 20141001 |
| [Hypermethylation of CpG island of DLC-1 gene and arsenic trioxide-induced DLC-1 gene demethylation in multiple myeloma]. | Zhonghua yi xue za zhi 20140930 |
| Low dose of arsenic trioxide triggers oxidative stress in zebrafish brain: expression of antioxidant genes. | Ecotoxicology and environmental safety 20140901 |
| [The apoptotic mechanism of hepatocellular carcinoma cell line (HepG2) induced by arsenic trioxide]. | Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20140901 |
| Retinoic acid synergizes ATO-mediated cytotoxicity by precluding Nrf2 activity in AML cells. | British journal of cancer 20140826 |
| Arsenic downregulates gene expression at the postsynaptic density in mouse cerebellum, including genes responsible for long-term potentiation and depression. | Toxicology letters 20140804 |
| Activation of the ubiquitin-proteasome system against arsenic trioxide cardiotoxicity involves ubiquitin ligase Parkin for mitochondrial homeostasis. | Toxicology 20140801 |
| Blood biochemistry, thyroid hormones, and oxidant/antioxidant status of guinea pigs challenged with sodium arsenite or arsenic trioxide. | Biological trace element research 20140801 |
| Src family kinase inhibitor PP2 enhances differentiation of acute promyelocytic leukemia cell line induced by combination of all-trans-retinoic acid and arsenic trioxide. | Leukemia research 20140801 |
| Arsenic trioxide in front-line therapy of acute promyelocytic leukemia (C9710): prognostic significance of FLT3 mutations and complex karyotype. | Leukemia & lymphoma 20140701 |
| Identification of recurrent SMO and BRAF mutations in ameloblastomas. | Nature genetics 20140701 |
| Arsenic trioxide attenuates the invasion potential of human liver cancer cells through the demethylation-activated microRNA-491. | Toxicology letters 20140605 |
| Effects of arsenic on osteoblast differentiation in vitro and on bone mineral density and microstructure in rats. | Environmental health perspectives 20140601 |
| Arsenic trioxide induced indirect and direct inhibition of glutathione reductase leads to apoptosis in rat hepatocytes. | Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20140601 |
| Downregulation of thymidylate synthase with arsenic trioxide in lung adenocarcinoma. | International journal of oncology 20140601 |
| Aberrant overexpression of FOXM1 transcription factor plays a critical role in lung carcinogenesis induced by low doses of arsenic. | Molecular carcinogenesis 20140501 |
| [Effect of arsenic trioxide and 5-aza-2'-deoxycytidine on SHP-1, JAK3, TYK2 gene expression in K562 cells]. | Zhongguo shi yan xue ye xue za zhi 20140401 |
| The effect to IL-3Ralpha, downstream PI3k/Akt signaling of all-trans retinoic acid and arsenic trioxide in NB4 cells. | Die Pharmazie 20140401 |
| Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells. | Journal of molecular medicine (Berlin, Germany) 20140301 |
| Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment. | The Journal of pharmacology and experimental therapeutics 20140301 |
| [Effects of arsenic poisoning on neuronal cell apoptosis and mRNA and protein expression of calpain 1, calpain 2, and cdk5/p25]. | Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20140301 |
| Identifying arsenic trioxide (ATO) functions in leukemia cells by using time series gene expression profiles. | Gene 20140210 |
| Arsenic trioxide induces unfolded protein response in vascular endothelial cells. | Archives of toxicology 20140201 |
| Arsenic trioxide suppressed mantle cell lymphoma by downregulation of cyclin D1. | Annals of hematology 20140201 |
| Antitumor efficacy of DMSA modified Fe3O4 magnetic nanoparticles combined with arsenic trioxide and adriamycin in Raji cells. | Journal of biomedical nanotechnology 20140201 |
| Arsenic trioxide and other arsenical compounds inhibit the NLRP1, NLRP3, and NAIP5/NLRC4 inflammasomes. | Journal of immunology (Baltimore, Md. : 1950) 20140115 |
| Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro. | The Journal of thoracic and cardiovascular surgery 20140101 |
| Arsenic trioxide induces apoptosis in human platelets via C-Jun NH2-terminal kinase activation. | PloS one 20140101 |
| Arsenic trioxide inhibits Hedgehog, Notch and stem cell properties in glioblastoma neurospheres. | Acta neuropathologica communications 20140101 |
| Arsenic trioxide inhibits transforming growth factor-β1-induced fibroblast to myofibroblast differentiation in vitro and bleomycin induced lung fibrosis in vivo. | Respiratory research 20140101 |
| Nutlin-3 overcomes arsenic trioxide resistance and tumor metastasis mediated by mutant p53 in Hepatocellular Carcinoma. | Molecular cancer 20140101 |
| Matrix metalloproteinase-9 is involved in chronic lymphocytic leukemia cell response to fludarabine and arsenic trioxide. | PloS one 20140101 |
| Upregulation of ID2 antagonizes arsenic trioxide-induced antitumor effects in cancer cells. | Tumori 20140101 |
| Arsenic trioxide exerts anti-lung cancer activity by inhibiting angiogenesis. | Current cancer drug targets 20140101 |
| Arsenic trioxide and resveratrol show synergistic anti-leukemia activity and neutralized cardiotoxicity. | PloS one 20140101 |
| The roles of mitoferrin-2 in the process of arsenic trioxide-induced cell damage in human gliomas. | European journal of medical research 20140101 |
| Silencing SATB1 inhibits the malignant phenotype and increases sensitivity of human osteosarcoma U2OS cells to arsenic trioxide. | International journal of medical sciences 20140101 |
| Sensitivity of leukemic T-cell lines to arsenic trioxide cytotoxicity is dependent on the induction of phosphatase B220/CD45R expression at the cell surface. | Molecular cancer 20140101 |
| Synergistic effects of arsenic trioxide combined with ascorbic acid in human osteosarcoma MG-63 cells: a systems biology analysis. | European review for medical and pharmacological sciences 20140101 |
| Redirecting apoptosis to aponecrosis induces selective cytotoxicity to pancreatic cancer cells through increased ROS, decline in ATP levels, and VDAC. | Molecular cancer therapeutics 20131201 |
| The novel arsenical Darinaparsin circumvents BRG1-dependent, HO-1-mediated cytoprotection in leukemic cells. | Leukemia 20131101 |
| Sodium arsenite and arsenic trioxide differently affect the oxidative stress, genotoxicity and apoptosis in A549 cells: an implication for the paradoxical mechanism. | Environmental toxicology and pharmacology 20131101 |
| VEGF depletion enhances bcr-abl-specific sensitivity of arsenic trioxide in chronic myelogenous leukemia. | Hematology (Amsterdam, Netherlands) 20131101 |
| The deubiquitinating enzyme USP37 regulates the oncogenic fusion protein PLZF/RARA stability. | Oncogene 20131024 |
| Characterization of arsenic trioxide resistant clones derived from Jurkat leukemia T cell line: focus on PI3K/Akt signaling pathway. | Chemico-biological interactions 20131005 |
| SUMO1 negatively regulates the transcriptional activity of EVI1 and significantly increases its co-localization with EVI1 after treatment with arsenic trioxide. | Biochimica et biophysica acta 20131001 |
| Role of cysteine 288 in nucleophosmin cytoplasmic mutations: sensitization to toxicity induced by arsenic trioxide and bortezomib. | Leukemia 20131001 |
| The synergistic antitumor activity of arsenic trioxide and vitamin K2 in HL-60 cells involves increased ROS generation and regulation of the ROS-dependent MAPK signaling pathway. | Die Pharmazie 20131001 |
| Upregulation of microRNA-1 and microRNA-133 contributes to arsenic-induced cardiac electrical remodeling. | International journal of cardiology 20130910 |
| Autocrine human growth hormone increases sensitivity of mammary carcinoma cell to arsenic trioxide-induced apoptosis. | Molecular and cellular endocrinology 20130905 |
| BIBR 1532 increases arsenic trioxide-mediated apoptosis in acute promyelocytic leukemia cells: therapeutic potential for APL. | Anti-cancer agents in medicinal chemistry 20130901 |
| Enhanced cell growth and tumorigenicity of rat glioma cells by stable expression of human CD133 through multiple molecular actions. | Glia 20130901 |
| Treatment of acute promyelocytic leukemia with arsenic trioxide: clinical results and open questions. | Expert review of anticancer therapy 20130901 |
| Endoplasmic reticulum stress-mediated apoptosis in imatinib-resistant leukemic K562-r cells triggered by AMN107 combined with arsenic trioxide. | Experimental biology and medicine (Maywood, N.J.) 20130801 |
| Metallothionein prevention of arsenic trioxide-induced cardiac cell death is associated with its inhibition of mitogen-activated protein kinases activation in vitro and in vivo. | Toxicology letters 20130718 |
| Arsenic trioxide depletes cancer stem-like cells and inhibits repopulation of neurosphere derived from glioblastoma by downregulation of Notch pathway. | Toxicology letters 20130620 |
| SUMO regulates proteasome-dependent degradation of FLASH/Casp8AP2. | Cell cycle (Georgetown, Tex.) 20130615 |
| Arsenic trioxide induces cardiac fibroblast apoptosis in vitro and in vivo by up-regulating TGF-β1 expression. | Toxicology letters 20130607 |
| Resveratrol protects against arsenic trioxide-induced nephrotoxicity by facilitating arsenic metabolism and decreasing oxidative stress. | Archives of toxicology 20130601 |
| Synergistic anticancer activity of arsenic trioxide with erlotinib is based on inhibition of EGFR-mediated DNA double-strand break repair. | Molecular cancer therapeutics 20130601 |
| Aquaporin 9, a promising predictor for the cytocidal effects of arsenic trioxide in acute promyelocytic leukemia cell lines and primary blasts. | Oncology reports 20130601 |
| Reciprocal regulation of cyclooxygenase 2 and heme oxygenase 1 upon arsenic trioxide exposure in normal human lung fibroblast. | Journal of biochemical and molecular toxicology 20130601 |
| Arsenic trioxide-enhanced, matrine-induced apoptosis in multiple myeloma cell lines. | Planta medica 20130601 |
| [Demethylation effect of inhibitor As2O3 on expression of SHP-1 and C-kit genes in leukemia HL-60 cells]. | Zhongguo shi yan xue ye xue za zhi 20130601 |
| [Homoharringtonine combined arsenic trioxide induced apoptosis in human multiple myeloma cell line RPMI 8226: an experimental research]. | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20130601 |
| Phase 2 study of arsenic trioxide followed by autologous hematopoietic cell transplantation for relapsed acute promyelocytic leukemia. | Blood 20130418 |
| Selective inhibition of the NLRP3 inflammasome by targeting to promyelocytic leukemia protein in mouse and human. | Blood 20130418 |
| α-Lipoic acid protects against arsenic trioxide-induced acute QT prolongation in anesthetized guinea pigs. | European journal of pharmacology 20130405 |
| Osteoblasts survive the arsenic trioxide treatment by activation of ATM-mediated pathway. | Biochemical pharmacology 20130401 |
| PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies. | Proceedings of the National Academy of Sciences of the United States of America 20130312 |
| Cardioprotective effect of salvianolic acid B against arsenic trioxide-induced injury in cardiac H9c2 cells via the PI3K/Akt signal pathway. | Toxicology letters 20130204 |
| Arsenic trioxide prevents nitric oxide production in lipopolysaccharide -stimulated RAW 264.7 by inhibiting a TRIF-dependent pathway. | Cancer science 20130201 |
| Arsenic suppresses cell survival via Pirh2-mediated proteasomal degradation of ΔNp63 protein. | The Journal of biological chemistry 20130201 |
| Arsenic trioxide treatment of rabbit liver VX-2 carcinoma via hepatic arterial cannulation-induced apoptosis and decreased levels of survivin in the tumor tissue. | Croatian medical journal 20130201 |
| Combination therapy with 5-amino-4-imidazolecarboxamide riboside and arsenic trioxide in acute myeloid leukemia cells involving AMPK/TSC2/mTOR pathway. | Die Pharmazie 20130201 |
| [Clinical investigation of homoharringtonine in combination with all-transretinoic acid and arsenic trioxide for acute promyelocytic leukemia]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20130201 |
| Resveratrol attenuates hepatotoxicity of rats exposed to arsenic trioxide. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20130101 |
| Arsenic trioxide-induced hERG K(+) channel deficiency can be rescued by matrine and oxymatrine through up-regulating transcription factor Sp1 expression. | Biochemical pharmacology 20130101 |
| A case report of acute myeloid leukemia after liver transplantation. | Acta haematologica 20130101 |
| Genistein ameliorates adverse cardiac effects induced by arsenic trioxide through preventing cardiomyocytes apoptosis. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20130101 |
| Arsenic trioxide induced apoptosis in retinoblastoma cells by abnormal expression of microRNA-376a. | Neoplasma 20130101 |
| Expression of AFP and STAT3 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in AFP-producing gastric cancer cells. | PloS one 20130101 |
| Growth and differentiation effects of Homer3 on a leukemia cell line. | Asian Pacific journal of cancer prevention : APJCP 20130101 |
| Inhibition of accelerated rejection mediated by alloreactive CD4⁺ memory T cells and prolonged allograft survival by arsenic trioxide. | Immunological investigations 20130101 |
| Arsenic trioxide prevents osteosarcoma growth by inhibition of GLI transcription via DNA damage accumulation. | PloS one 20130101 |
| The combination of arsenic, interferon-alpha, and zidovudine restores an 'immunocompetent-like' cytokine expression profile in patients with adult T-cell leukemia lymphoma. | Retrovirology 20130101 |
| 2-methoxyestradiol induces mitotic arrest, apoptosis, and synergistic cytotoxicity with arsenic trioxide in human urothelial carcinoma cells. | PloS one 20130101 |
| Indomethacin-enhanced anticancer effect of arsenic trioxide in A549 cell line: involvement of apoptosis and phospho-ERK and p38 MAPK pathways. | BioMed research international 20130101 |
| Effects of arsenic trioxide alone and in combination with bortezomib in multiple myeloma RPMI 8266 cells. | Asian Pacific journal of cancer prevention : APJCP 20130101 |
| Arsenic trioxide overcomes rapamycin-induced feedback activation of AKT and ERK signaling to enhance the anti-tumor effects in breast cancer. | PloS one 20130101 |
| 2-Deoxy-D-glucose cooperates with arsenic trioxide to induce apoptosis in leukemia cells: involvement of IGF-1R-regulated Akt/mTOR, MEK/ERK and LKB-1/AMPK signaling pathways. | Biochemical pharmacology 20121215 |
| Ethacrynic acid and a derivative enhance apoptosis in arsenic trioxide-treated myeloid leukemia and lymphoma cells: the role of glutathione S-transferase p1-1. | Clinical cancer research : an official journal of the American Association for Cancer Research 20121215 |
| Arsenic trioxide (ATO) influences the gene expression of metallothioneins in human glioblastoma cells. | Biological trace element research 20121201 |
| Endoplasmic reticulum stress contributes to arsenic trioxide-induced apoptosis in drug-sensitive and -resistant leukemia cells. | Leukemia research 20121201 |
| Linker for activation of T-cell family member2 (LAT2) a lipid raft adaptor protein for AKT signaling, is an early mediator of alkylphospholipid anti-leukemic activity. | Molecular & cellular proteomics : MCP 20121201 |
| Protective and antioxidant role of selenium on arsenic trioxide-induced oxidative stress and genotoxicity in the fish hepatoma cell line PLHC-1. | Environmental toxicology and chemistry 20121201 |
| Effects of arsenic trioxide (As(2)O(3)) on airway remodeling in a murine model of bronchial asthma. | Canadian journal of physiology and pharmacology 20121201 |
| [Inhibitory effect of arsenic trioxide on invasion in human hepatocellular carcinoma SMMC-7721 cells and its mechanism]. | Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20121201 |
| Synergism between carnosic acid and arsenic trioxide on induction of acute myeloid leukemia cell apoptosis is associated with modulation of PTEN/Akt signaling pathway. | Chinese journal of integrative medicine 20121201 |
| Arsenic trioxide regulates the production and activities of matrix metalloproteinases-1, -2, and -9 in fibroblasts and THP-1. | Chinese medical journal 20121201 |
| Allogeneic stem cell transplantation for advanced acute promyelocytic leukemia in the ATRA and ATO era. | Haematologica 20121101 |
| Arsenic trioxide induces G2/M arrest in hepatocellular carcinoma cells by increasing the tumor suppressor PTEN expression. | Journal of cellular biochemistry 20121101 |
| Phase I study of arsenic trioxide and temozolomide in combination with radiation therapy in patients with malignant gliomas. | Journal of neuro-oncology 20121101 |
| Sulforaphane synergistically enhances the cytotoxicity of arsenic trioxide in multiple myeloma cells via stress-mediated pathways. | Oncology reports 20121101 |
| Granulocyte colony-stimulating factor potentiates differentiation induction by all-trans retinoic acid and arsenic trioxide and enhances arsenic uptake in the acute promyelocytic leukemia cell line HT93A. | Oncology reports 20121101 |
| Long term curative effects of sequential therapy with all-trans retinoic acid, arsenious oxide and chemotherapy on patients with acute promyelocytic leukemia. | Hematology (Amsterdam, Netherlands) 20121101 |
| Autophagic degradation of the BCR-ABL oncoprotein and generation of antileukemic responses by arsenic trioxide. | Blood 20121025 |
| Arsenic-induced interstitial myocardial fibrosis reveals a new insight into drug-induced long QT syndrome. | Cardiovascular research 20121001 |
| Arsenic trioxide synergizes with everolimus (Rad001) to induce cytotoxicity of ovarian cancer cells through increased autophagy and apoptosis. | Endocrine-related cancer 20121001 |
| Arsenic trioxide-induced growth arrest of breast cancer MCF-7 cells involving FOXO3a and IκB kinase β expression and localization. | Cancer biotherapy & radiopharmaceuticals 20121001 |
| Polycomb (PcG) proteins, BMI1 and SUZ12, regulate arsenic-induced cell transformation. | The Journal of biological chemistry 20120914 |
| Antitumor effect of arsenic trioxide in human K562 and K562/ADM cells by autophagy. | Toxicology mechanisms and methods 20120901 |
| Altered arsenic disposition in experimental nonalcoholic fatty liver disease. | Drug metabolism and disposition: the biological fate of chemicals 20120901 |
| [Arsenic trioxide restores ERα expression in ERα-negative human breast cancer cells and its treatment efficacy in combination with tamoxifen in xenografts in nude mice]. | Zhonghua zhong liu za zhi [Chinese journal of oncology] 20120901 |
| All-trans-retinoic acid, idarubicin, and IV arsenic trioxide as initial therapy in acute promyelocytic leukemia (APML4). | Blood 20120823 |
| ATRA plus arsenic gets another 'A' in APL. | Blood 20120823 |
| A phase 2 trial of combination therapy with thalidomide, arsenic trioxide, dexamethasone, and ascorbic acid (TADA) in patients with overlap myelodysplastic/myeloproliferative neoplasms (MDS/MPN) or primary myelofibrosis (PMF). | Cancer 20120815 |
| Regulatory role of KEAP1 and NRF2 in PPARγ expression and chemoresistance in human non-small-cell lung carcinoma cells. | Free radical biology & medicine 20120815 |
| Carbonyl reductase 1 offers a novel therapeutic target to enhance leukemia treatment by arsenic trioxide. | Cancer research 20120815 |
| How to manage acute promyelocytic leukemia. | Leukemia 20120801 |
| Arsenic trioxide induces human pulmonary fibroblast cell death via increasing ROS levels and GSH depletion. | Oncology reports 20120801 |
| Effect of phosphatase and tensin homology deleted on chromosome 10 (PTEN) gene transfection on reversal of multidrug resistance in K562/ADM cells. | Leukemia & lymphoma 20120701 |
| Arsenic trioxide induces abnormal mitotic spindles through a PIP4KIIγ/Rho pathway. | Toxicological sciences : an official journal of the Society of Toxicology 20120701 |
| Inhibition of the heat shock response by PI103 enhances the cytotoxicity of arsenic trioxide. | Toxicological sciences : an official journal of the Society of Toxicology 20120701 |
| Combination therapy with arsenic trioxide, all-trans retinoic acid, and chemotherapy in acute promyelocytic leukemia patients with various relapse risks. | Leukemia research 20120701 |
| The organic arsenic derivative GMZ27 induces PML-RARα-independent apoptosis in myeloid leukemia cells. | Anticancer research 20120701 |
| Provocative pearls in diagnosing and treating acute promyelocytic leukemia. | Oncology (Williston Park, N.Y.) 20120701 |
| Cytotoxic effect of arsenic trioxide on acute promyelocytic leukemia cells through suppression of NFkβ-dependent induction of hTERT due to down-regulation of Pin1 transcription. | Hematology (Amsterdam, Netherlands) 20120701 |
| [microRNAs expression profile in acute promyelocytic leukemia cell differentiation induced by all-trans retinoic acid and arsenic trioxide]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20120701 |
| Darinaparsin: solid tumor hypoxic cytotoxin and radiosensitizer. | Clinical cancer research : an official journal of the American Association for Cancer Research 20120615 |
| Arsenic trioxide induces apoptosis of p53 null osteosarcoma MG63 cells through the inhibition of catalase. | Medical oncology (Northwood, London, England) 20120601 |
| Assessment of the involvement of oxidative stress and Mitogen-Activated Protein Kinase signaling pathways in the cytotoxic effects of arsenic trioxide and its combination with sulindac or its metabolites: sulindac sulfide and sulindac sulfone on human leukemic cell lines. | Medical oncology (Northwood, London, England) 20120601 |
| Characterization of arsenic-induced cytogenetic alterations in acute promyelocytic leukemia cell line, NB4. | Medical oncology (Northwood, London, England) 20120601 |
| A combination of thalidomide and arsenic trioxide is effective and well tolerated in patients with myelodysplastic syndromes. | Leukemia research 20120601 |
| Inhibition of small GTPase RalA regulates growth and arsenic-induced apoptosis in chronic myeloid leukemia (CML) cells. | Cellular signalling 20120601 |
| The influence of modified pluronic F127 copolymers with higher phase transition temperature on arsenic trioxide-releasing properties and toxicity in a subcutaneous model of rats. | AAPS PharmSciTech 20120601 |
| Long-term remission in a case of acute promyelocytic leukemia patient with marked myelofibrosis treated with arsenic trioxide, all-trans retinoic acid and consolidation therapy with daunorubicin plus cytarabine. | Leukemia research 20120601 |
| Arsenic trioxide affects bone remodeling by effects on osteoblast differentiation and function. | Bone 20120601 |
| Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. | Toxicology and applied pharmacology 20120601 |
| NADPH oxidase-produced superoxide mediates EGFR transactivation by c-Src in arsenic trioxide-stimulated human keratinocytes. | Archives of toxicology 20120601 |
| Bleeding and thrombosis in acute promyelocytic leukemia. | American journal of hematology 20120601 |
| Arsenic induces apoptosis in myoblasts through a reactive oxygen species-induced endoplasmic reticulum stress and mitochondrial dysfunction pathway. | Archives of toxicology 20120601 |
| [Effects of arsenic trioxide on the proliferation of human breast cancer SKBR-3 cell and the expression of Notch1]. | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20120601 |
| Arsenic trioxide prevents murine sclerodermatous graft-versus-host disease. | Journal of immunology (Baltimore, Md. : 1950) 20120515 |
| Arsenic trioxide (As₂O₃) inhibits murine WEHI-3 leukemia in BALB/c mice in vivo. | Environmental toxicology 20120501 |
| A randomized phase 2 trial of a preparative regimen of bortezomib, high-dose melphalan, arsenic trioxide, and ascorbic acid. | Cancer 20120501 |
| Opposite effects of arsenic trioxide on the Nrf2 pathway in oral squamous cell carcinoma in vitro and in vivo. | Cancer letters 20120501 |
| Promyelocytic leukemia nuclear bodies support a late step in DNA double-strand break repair by homologous recombination. | Journal of cellular biochemistry 20120501 |
| MAPK inhibitors and siRNAs differentially affect cell death and ROS levels in arsenic trioxide-treated human pulmonary fibroblast cells. | Oncology reports 20120501 |
| The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA. | Cancer research 20120501 |
| Quantification of PML/RARa transcript after induction predicts outcome in children with acute promyelocytic leukemia. | International journal of hematology 20120501 |
| Arsenic trioxide for management of acute promyelocytic leukemia: current evidence on its role in front-line therapy and recurrent disease. | Expert opinion on pharmacotherapy 20120501 |
| Targeted inhibition of VEGF-modulated survival and arsenic sensitivity in acute myeloid leukemia (AML). | Hematology (Amsterdam, Netherlands) 20120501 |
| [Effect of arsenic trioxide and daunorubicin on procoagulant activity of acute promyelocytic leukemia cells]. | Zhonghua yi xue za zhi 20120424 |
| Role of minimal residual disease monitoring in acute promyelocytic leukemia treated with arsenic trioxide in frontline therapy. | Blood 20120412 |
| Arsenic trioxide induces human pulmonary fibroblast cell death via the regulation of Bcl-2 family and caspase-8. | Molecular biology reports 20120401 |
| Are low-intensity induction strategies better for older patients with acute myeloid leukemia? | Leukemia research 20120401 |
| [Expression of homeobox A9 in myeloid leukemia cell line HL-60 and effect of drugs on its expression]. | Zhongguo shi yan xue ye xue za zhi 20120401 |
| Differentiation syndrome in patients with acute promyelocytic leukemia. | Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20120301 |
| (+)α-Tocopheryl succinate inhibits the mitochondrial respiratory chain complex I and is as effective as arsenic trioxide or ATRA against acute promyelocytic leukemia in vivo. | Leukemia 20120301 |
| Impact of arsenic trioxide in the treatment of acute promyelocytic leukemia. | Leukemia 20120301 |
| Pathogenesis and treatment of leukemia: an Asian perspective. | Expert opinion on therapeutic targets 20120301 |
| Tetramethylpyrazine potentiates arsenic trioxide activity against HL-60 cell lines. | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20120301 |
| [Inhibitory mechanism on growth of MA-891 cells by arsenic trioxide]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120301 |
| [Current treatment of acute myeloid leukaemia in adults]. | Orvosi hetilap 20120219 |
| Microarray analysis revealed dysregulation of multiple genes associated with chemoresistance to As(2)O(3) and increased tumor aggressiveness in a newly established arsenic-resistant ovarian cancer cell line, OVCAR-3/AsR. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120214 |
| As(2)O (3) oxidation by vitamin C: cell culture studies. | Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20120201 |
| Manipulation of cellular redox parameters for improving therapeutic responses in B-cell lymphoma and multiple myeloma. | Journal of cellular biochemistry 20120201 |
| Synergistic effects of arsenic trioxide and silibinin on apoptosis and invasion in human glioblastoma U87MG cell line. | Neurochemical research 20120201 |
| Alteration in miRNA gene expression pattern in acute promyelocytic leukemia cell induced by arsenic trioxide: a possible mechanism to explain arsenic multi-target action. | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20120201 |
| [Regulation of all-trans retinoic acid and arsenic trioxide on CD44v6 expression in NB4 cells]. | Zhongguo shi yan xue ye xue za zhi 20120201 |
| Effects of arsenic trioxide combined with bortezomib on apoptosis of multiple myeloma cell line KM3 and its mechanisms. | Zhongguo shi yan xue ye xue za zhi 20120201 |
| [Changes of cdk5, p35 and p53 gene expression levels in arsenic-induced neural cell apoptosis]. | Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20120201 |
| Arsenic trioxide treatment decreases the oxygen consumption rate of tumor cells and radiosensitizes solid tumors. | Cancer research 20120115 |
| Arsenic trioxide inhibits Ewing's sarcoma cell invasiveness by targeting p38(MAPK) and c-Jun N-terminal kinase. | Anti-cancer drugs 20120101 |
| Synergistic antitumor activity of oridonin and arsenic trioxide on hepatocellular carcinoma cells. | International journal of oncology 20120101 |
| S100A8-targeting siRNA enhances arsenic trioxide-induced myeloid leukemia cell death by down-regulating autophagy. | International journal of molecular medicine 20120101 |
| Curing APL through PML/RARA degradation by As2O3. | Trends in molecular medicine 20120101 |
| Speciation of arsenic trioxide metabolites in peripheral blood and bone marrow from an acute promyelocytic leukemia patient. | Journal of hematology & oncology 20120101 |
| Molecular targeting therapy against promyelocytic leukemia protein using arsenic acids in experimental intracranial medulloblastoma. | Neurologia medico-chirurgica 20120101 |
| Arsenic trioxide enhances the radiation sensitivity of androgen-dependent and -independent human prostate cancer cells. | PloS one 20120101 |
| Arsenic trioxide exerts antimyeloma effects by inhibiting activity in the cytoplasmic substrates of histone deacetylase 6. | PloS one 20120101 |
| A new era for an ancient drug: arsenic trioxide and Hedgehog signaling. | Vitamins and hormones 20120101 |
| Effects of arsenic trioxide on radiofrequency ablation of VX2 liver tumor: intraarterial versus intravenous administration. | Korean journal of radiology 20120101 |
| Therapeutic effect of Arsenicum album on leukocytes. | International journal of molecular sciences 20120101 |
| Arsenic induces functional re-expression of estrogen receptor α by demethylation of DNA in estrogen receptor-negative human breast cancer. | PloS one 20120101 |
| Factors determining sensitivity and resistance of tumor cells to arsenic trioxide. | PloS one 20120101 |
| Radiosensitivity enhancement by arsenic trioxide in conjunction with hyperthermia in the EC-1 esophageal carcinoma cell line. | Asian Pacific journal of cancer prevention : APJCP 20120101 |
| Arsenic trioxide inhibits cell growth and induces apoptosis through inactivation of notch signaling pathway in breast cancer. | International journal of molecular sciences 20120101 |
| Differential effects of arsenic trioxide on chemosensitization in human hepatic tumor and stellate cell lines. | BMC cancer 20120101 |
| Arsenic trioxide and ascorbic acid interfere with the BCL2 family genes in patients with myelodysplastic syndromes: an ex-vivo study. | Journal of hematology & oncology 20120101 |
| Requirement of PML SUMO interacting motif for RNF4- or arsenic trioxide-induced degradation of nuclear PML isoforms. | PloS one 20120101 |
| Near infrared imaging of EGFR of oral squamous cell carcinoma in mice administered arsenic trioxide. | PloS one 20120101 |
| Prognostic significance of CD44v6/v7 in acute promyelocytic leukemia. | Asian Pacific journal of cancer prevention : APJCP 20120101 |
| Potential role of sodium-proton exchangers in the low concentration arsenic trioxide-increased intracellular pH and cell proliferation. | PloS one 20120101 |
| Oral arsenic trioxide-based maintenance regimens for first complete remission of acute promyelocytic leukemia: a 10-year follow-up study. | Blood 20111215 |
| Combination of arsenic trioxide and BCNU synergistically triggers redox-mediated autophagic cell death in human solid tumors. | Free radical biology & medicine 20111215 |
| Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. | Medical oncology (Northwood, London, England) 20111201 |
| Long-term survey of outcome in acute promyelocytic leukemia: a single center experience in 340 patients. | Medical oncology (Northwood, London, England) 20111201 |
| Arsenic trioxide may improve the prognosis of APL with ider(17)(q10): report of a rare adult case of acute promyelocytic leukemia with ider(17)(q10)t(15;17) showing poor response to all-trans retinoic acid. | Annals of hematology 20111201 |
| Increased apoptotic efficacy of lonidamine plus arsenic trioxide combination in human leukemia cells. Reactive oxygen species generation and defensive protein kinase (MEK/ERK, Akt/mTOR) modulation. | Biochemical pharmacology 20111201 |
| Current treatment strategy of acute promyelocytic leukemia. | Frontiers of medicine 20111201 |
| Arsenic oxide targets stem cell marker CD133/prominin-1 in gallbladder carcinoma. | Cancer letters 20111128 |
| Enhanced suppression of tumor growth by concomitant treatment of human lung cancer cells with suberoylanilide hydroxamic acid and arsenic trioxide. | Toxicology and applied pharmacology 20111115 |
| Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells. | Cancer biology & therapy 20111115 |
| Phase 1 study of arsenic trioxide, high-dose cytarabine, and idarubicin to down-regulate constitutive signal transducer and activator of transcription 3 activity in patients aged <60 years with acute myeloid leukemia. | Cancer 20111101 |
| The cystine/cysteine cycle and GSH are independent and crucial antioxidant systems in malignant melanoma cells and represent druggable targets. | Antioxidants & redox signaling 20111101 |
| Advances in therapies for acute promyelocytic leukemia. | Cancer science 20111101 |
| Epoxyeicosatrienoic acids attenuate reactive oxygen species level, mitochondrial dysfunction, caspase activation, and apoptosis in carcinoma cells treated with arsenic trioxide. | The Journal of pharmacology and experimental therapeutics 20111101 |
| JWA enhances As₂O₃-induced tubulin polymerization and apoptosis via p38 in HeLa and MCF-7 cells. | Apoptosis : an international journal on programmed cell death 20111101 |
| Proteomic identification of Hsp70 as a new Plk1 substrate in arsenic trioxide-induced mitotically arrested cells. | Proteomics 20111101 |
| Antiangiogenesis in myelodysplastic syndrome. | Current cancer drug targets 20111101 |
| TCTP is a critical survival factor that protects cancer cells from oxidative stress-induced cell-death. | Experimental cell research 20111015 |
| Acute exposure of arsenic tri-oxide produces hyperglycemia in both sexes of an Indian teleost, Clarias batrachus (Linn.). | Archives of environmental contamination and toxicology 20111001 |
| AID expression is correlated with Bcr-Abl expression in CML-LBC and can be down-regulated by As2O3 and/or imatinib. | Leukemia research 20111001 |
| miR-190-mediated downregulation of PHLPP contributes to arsenic-induced Akt activation and carcinogenesis. | Toxicological sciences : an official journal of the Society of Toxicology 20111001 |
| Arsenic trioxide and radiation enhance apoptotic effects in HL-60 cells through increased ROS generation and regulation of JNK and p38 MAPK signaling pathways. | Chemico-biological interactions 20110905 |
| Arsenic trioxide and olanzapine co-administration: case analysis. | Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20110901 |
| Inhibition of heme oxygenase-1 enhances anti-cancer effects of arsenic trioxide on glioma cells. | Journal of neuro-oncology 20110901 |
| Arsenic trioxide induces autophagy and apoptosis in human glioma cells in vitro and in vivo through downregulation of survivin. | Journal of molecular medicine (Berlin, Germany) 20110901 |
| Suppression of TG-interacting factor sensitizes arsenic trioxide-induced apoptosis in human hepatocellular carcinoma cells. | The Biochemical journal 20110901 |
| Arsenic trioxide re-sensitizes ERα-negative breast cancer cells to endocrine therapy by restoring ERα expression in vitro and in vivo. | Oncology reports 20110901 |
| Applicability of a 'Pick a Winner' trial design to acute myeloid leukemia. | Blood 20110901 |
| The efficacy and safety of arsenic trioxide with or without all-trans retinoic acid for the treatment of acute promyelocytic leukemia: a meta-analysis. | Leukemia research 20110901 |
| Arsenic increases lipopolysaccharide-dependent expression of interleukin-8 gene by stimulating a redox-sensitive pathway that strengthens p38-kinase activation. | Molecular immunology 20110901 |
| Potentiation of arsenic trioxide-induced apoptosis by 8-bromo-7-methoxychrysin in human leukemia cells involves depletion of intracellular reduced glutathione. | Acta biochimica et biophysica Sinica 20110901 |
| Combination decitabine, arsenic trioxide, and ascorbic acid for the treatment of myelodysplastic syndrome and acute myeloid leukemia: a phase I study. | American journal of hematology 20110901 |
| Integrated microfluidic array plate (iMAP) for cellular and molecular analysis. | Lab on a chip 20110821 |
| Missense mutations in PML-RARA are critical for the lack of responsiveness to arsenic trioxide treatment. | Blood 20110811 |
| Arsenic trioxide reduces 2,4,6-trinitrobenzene sulfonic acid-induced murine colitis via nuclear factor-κB down-regulation and caspase-3 activation. | Innate immunity 20110801 |
| Combination of Poly I:C and arsenic trioxide triggers apoptosis synergistically via activation of TLR3 and mitochondrial pathways in hepatocellular carcinoma cells. | Cell biology international 20110801 |
| Sulindac and its metabolites: sulindac sulfide and sulindac sulfone enhance cytotoxic effects of arsenic trioxide on leukemic cell lines. | Toxicology in vitro : an international journal published in association with BIBRA 20110801 |
| Proteasome inhibition in myelodysplastic syndromes and acute myelogenous leukemia cell lines. | Cancer investigation 20110801 |
| Arsenic trioxide reduces drug resistance to adriamycin in leukemic K562/A02 cells via multiple mechanisms. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20110801 |
| YY1 is a novel potential therapeutic target for the treatment of HPV infection-induced cervical cancer by arsenic trioxide. | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20110801 |
| [Effects of bortezomib alone or combined with arsenic trioxide on the apoptosis of Jurkat cells and expression of livin mRNA]. | Zhongguo shi yan xue ye xue za zhi 20110801 |
| [Mechanism of loss of human esophageal cancer-related gene 4 (ECRG4) gene expression in esophageal squamous cell carcinoma cell line EC9706]. | Zhonghua zhong liu za zhi [Chinese journal of oncology] 20110801 |
| Arsenic trioxide-induced apoptosis in TM4 Sertoli cells: the potential involvement of p21 expression and p53 phosphorylation. | Toxicology 20110729 |
| Arsenic mediated disruption of promyelocytic leukemia protein nuclear bodies induces ganciclovir susceptibility in Epstein-Barr positive epithelial cells. | Virology 20110720 |
| Phase II study of single-agent arsenic trioxide for the front-line therapy of acute promyelocytic leukemia. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110710 |
| Arsenic trioxide regulates the apoptosis of glioma cell and glioma stem cell via down-regulation of stem cell marker Sox2. | Biochemical and biophysical research communications 20110708 |
| The expression of annexin II and its role in the fibrinolytic activity in acute promyelocytic leukemia. | Leukemia research 20110701 |
| The addition of arsenic trioxide to low-dose Ara-C in older patients with AML does not improve outcome. | Leukemia 20110701 |
| [All-trans retinoic acid and arsenic trioxide: their molecular mechanisms of action and updated clinical progress in APL therapy]. | [Rinsho ketsueki] The Japanese journal of clinical hematology 20110701 |
| Treatment of acute promyelocytic leukemia without cytotoxic chemotherapy. | Oncology (Williston Park, N.Y.) 20110701 |
| Successful treatment of relapsed and refractory extramedullary acute promyelocytic leukemia with tamibarotene. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110620 |
| Mediating effect of ROS on mtDNA damage and low ATP content induced by arsenic trioxide in mouse oocytes. | Toxicology in vitro : an international journal published in association with BIBRA 20110601 |
| Differential augmentative effects of buthionine sulfoximine and ascorbic acid in As2O3-induced ovarian cancer cell death: oxidative stress-independent and -dependent cytotoxic potentiation. | International journal of oncology 20110601 |
| Synergic effect of 3'-azido-3'-deoxythymidine and arsenic trioxide in suppressing hepatoma cells. | Anti-cancer drugs 20110601 |
| Inorganic arsenic causes cell apoptosis in mouse cerebrum through an oxidative stress-regulated signaling pathway. | Archives of toxicology 20110601 |
| Monomorphic ventricular tachycardia caused by arsenic trioxide therapy for acute promyelocytic leukaemia. | The journal of the Royal College of Physicians of Edinburgh 20110601 |
| [Apoptosis of KBM5R cell line with T315I point mutation induced by arsenic trioxide]. | Zhongguo shi yan xue ye xue za zhi 20110601 |
| [The inhibition effect of DFO alone and in combination with ATO on xenograft tumor growth of HL-60 cells in nude mice and its possible mechanism]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20110601 |
| Mutant p53 protein is targeted by arsenic for degradation and plays a role in arsenic-mediated growth suppression. | The Journal of biological chemistry 20110520 |
| Interaction between arsenic trioxide (ATO) and human neutrophils. | Human & experimental toxicology 20110501 |
| 5-Fluorouracil/Leucovorin and arsenic trioxide for patients with refractory/relapsed colorectal carcinoma: a clinical experience. | Acta oncologica (Stockholm, Sweden) 20110501 |
| Normoxically overexpressed hypoxia inducible factor 1-alpha is involved in arsenic trioxide resistance acquisition in hepatocellular carcinoma. | Annals of surgical oncology 20110501 |
| Arsenic trioxide induces procoagulant activity through phosphatidylserine exposure and microparticle generation in endothelial cells. | Thrombosis research 20110501 |
| Involvement of glycogen synthase kinase-3β in arsenic trioxide-induced p21 expression. | Toxicological sciences : an official journal of the Society of Toxicology 20110501 |
| Long-term remission after first-line single-agent treatment with arsenic trioxide of relapsed acute promyelocytic leukemia in an 8-year-old boy. | Pediatric hematology and oncology 20110501 |
| Treatment of relapsed acute promyelocytic leukemia by arsenic trioxide in Iran. | Archives of Iranian medicine 20110501 |
| Arsenic trioxide inhibits invasion/migration in SGC-7901 cells by activating the reactive oxygen species-dependent cyclooxygenase-2/matrix metalloproteinase-2 pathway. | Experimental biology and medicine (Maywood, N.J.) 20110501 |
| Lipoic acid ameliorates arsenic trioxide-induced HO-1 expression and oxidative stress in THP-1 monocytes and macrophages. | Chemico-biological interactions 20110425 |
| Arsenic trioxide and low-dose cytarabine for patients with intermediate-2 and high-risk myelodysplastic syndrome. | Leukemia research 20110401 |
| [NB4 cell apoptosis induced by bortezomib combined with As(2)O(3) and its mechanism]. | Zhongguo shi yan xue ye xue za zhi 20110401 |
| [Mechanism of apoptosis induced by bortezomib and As2O3 in APL cell line NB4]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20110401 |
| Autophagy modification augmented the treatment effects initiated by arsenic trioxide in NB4 cells. | Medical oncology (Northwood, London, England) 20110301 |
| miRNA-21 regulates arsenic-induced anti-leukemia activity in myelogenous cell lines. | Medical oncology (Northwood, London, England) 20110301 |
| Arsenic trioxide induces apoptosis through JNK and ERK in human mesothelioma cells. | Journal of cellular physiology 20110301 |
| A serotype 5/3 adenovirus expressing MDA-7/IL-24 infects renal carcinoma cells and promotes toxicity of agents that increase ROS and ceramide levels. | Molecular pharmacology 20110301 |
| Arsenic trioxide promotes senescence and regulates the balance of adipogenic and osteogenic differentiation in human mesenchymal stem cells. | Acta biochimica et biophysica Sinica 20110301 |
| Treatment of acute promyelocytic leukemia for older patients. | Journal of the National Comprehensive Cancer Network : JNCCN 20110301 |
| Development of chromanes as novel inhibitors of the uncoupling proteins. | Chemistry & biology 20110225 |
| Modern approaches to treating acute promyelocytic leukemia. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110210 |
| MicroRNA-dependent regulation of PTEN after arsenic trioxide treatment in bladder cancer cell line T24. | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20110201 |
| NFκB inhibitors induce cell death in glioblastomas. | Biochemical pharmacology 20110201 |
| Genistein potentiates the effect of arsenic trioxide against human hepatocellular carcinoma: role of Akt and nuclear factor-κB. | Cancer letters 20110201 |
| Hematological, biochemical and ionoregulatory responses of Indian major carp Catla catla during chronic sublethal exposure to inorganic arsenic. | Chemosphere 20110201 |
| E3 ubiquitin ligase Cbl-b potentiates the apoptotic action of arsenic trioxide by inhibiting the PI3K/Akt pathway. | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20110201 |
| Effect of arsenic trioxide on the treatment of children with newly diagnosed acute promyelocytic leukemia in China. | International journal of hematology 20110201 |
| Oxidative inactivation of the lipid phosphatase phosphatase and tensin homolog on chromosome ten (PTEN) as a novel mechanism of acquired long QT syndrome. | The Journal of biological chemistry 20110128 |
| Modified native cellulose fibers--a novel efficient adsorbent for both fluoride and arsenic. | Journal of hazardous materials 20110115 |
| Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway. | The Journal of clinical investigation 20110104 |
| Pattern of failure after limited margin radiotherapy and temozolomide for glioblastoma. | International journal of radiation oncology, biology, physics 20110101 |
| Outcome of therapy-related acute promyelocytic leukemia with or without arsenic trioxide as a component of frontline therapy. | Cancer 20110101 |
| Arsenic trioxide induces apoptosis of fibroblast-like synoviocytes and represents antiarthritis effect in experimental model of rheumatoid arthritis. | The Journal of rheumatology 20110101 |
| Cytotoxicity of arsenic trioxide is enhanced by (-)-epigallocatechin-3-gallate via suppression of ferritin in cancer cells. | Toxicology and applied pharmacology 20110101 |
| The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. | Experimental hematology 20110101 |
| microRNA expression alteration after arsenic trioxide treatment in HepG-2 cells. | Journal of gastroenterology and hepatology 20110101 |
| Protective effect of α-lipoic acid against arsenic trioxide-induced acute cardiac toxicity in rats. | Journal of pharmacological sciences 20110101 |
| [Anti-angiogenesis effect of arsenic trioxide plus cinobufacin on human hepatocarcinoma transplantation model nude mice]. | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20110101 |
| Arterial embolization hyperthermia using As2O3 nanoparticles in VX2 carcinoma-induced liver tumors. | PloS one 20110101 |
| Arsenic trioxide induces apoptosis of Burkitt lymphoma cell lines through multiple apoptotic pathways and triggers antiangiogenesis. | Oncology research 20110101 |
| [Effects of As2O3 and all-trans retinoic acid on the growth of HeLa cell line and their relation with gene NDRG1]. | Zhonghua zhong liu za zhi [Chinese journal of oncology] 20110101 |
| BIM-mediated AKT phosphorylation is a key modulator of arsenic trioxide-induced apoptosis in cisplatin-sensitive and -resistant ovarian cancer cells. | PloS one 20110101 |
| A study on the preparation and characterization of plasmid DNA and drug-containing magnetic nanoliposomes for the treatment of tumors. | International journal of nanomedicine 20110101 |
| Arsenic trioxide plus cisplatin/interferon α-2b/doxorubicin/capecitabine combination chemotherapy for unresectable hepatocellular carcinoma. | Hematology/oncology and stem cell therapy 20110101 |
| Exploiting mitochondrial dysfunction for effective elimination of imatinib-resistant leukemic cells. | PloS one 20110101 |
| Acute promyelocytic leukemia: an experience from a tertiary care centre in north India. | Indian journal of cancer 20110101 |
| Epstein - Barr virus Latent Membrane Protein 1 suppresses reporter activity through modulation of promyelocytic leukemia protein-nuclear bodies. | Virology journal 20110101 |
| Arsenic trioxide in patients with refractory multiple myeloma: a prospective, phase II, single-arm study. | Acta medica Iranica 20110101 |
| Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells. | Molecular cancer 20110101 |
| Nuclear Factor-κB modulates cellular glutathione and prevents oxidative stress in cancer cells. | Cancer letters 20101218 |
| Activation of the p38 MAPK/Akt/ERK1/2 signal pathways is required for the protein stabilization of CDC6 and cyclin D1 in low-dose arsenite-induced cell proliferation. | Journal of cellular biochemistry 20101215 |
| Synergistic apoptosis induction in leukemic cells by miR-15a/16-1 and arsenic trioxide. | Biochemical and biophysical research communications 20101210 |
| Arsenic trioxide induces a beclin-1-independent autophagic pathway via modulation of SnoN/SkiL expression in ovarian carcinoma cells. | Cell death and differentiation 20101201 |
| The impact of molecularly targeted therapies upon the understanding of leukemogenesis and the role of hematopoietic stem cell transplantation in acute promyelocytic leukemia. | Current stem cell research & therapy 20101201 |
| Arsenic modulates APOBEC3G-mediated restriction to HIV-1 infection in myeloid dendritic cells. | Journal of leukocyte biology 20101201 |
| Arsenic trioxide-mediated growth inhibition of myeloma cells is associated with an extrinsic or intrinsic signaling pathway through activation of TRAIL or TRAIL receptor 2. | Cancer biology & therapy 20101201 |
| [Mechanism of As(2)O(3) on hdpr1 gene demethylation in Jurkat cell line]. | Zhongguo shi yan xue ye xue za zhi 20101201 |
| Arsenic trioxide improves event-free and overall survival for adults with acute promyelocytic leukemia: North American Leukemia Intergroup Study C9710. | Blood 20101111 |
| Gefitinib enhances arsenic trioxide (AS2O3)-induced differentiation of acute promyelocytic leukemia cell line. | Leukemia research 20101101 |
| Arsenic trioxide influences viral replication in target organs of coxsackievirus B3-infected mice. | Microbes and infection 20101101 |
| [Acetyl-11-keto-beta-boswellic acid and arsenic trioxide regulate the productions and activities of matrix metalloproteinases in human skin fibroblasts and human leukemia cell line THP-1]. | Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20101101 |
| [Prevention of posterior capsule opacification by combination of arsenic trioxide and perfect capsule]. | [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20101101 |
| [A successful case of tanshinone II A treatment for relapsed acute promyelocytic leukemia after maintainance therapy of all-trans retinoic acid and arsenic trioxide]. | Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20101101 |
| Curcumin stimulates reactive oxygen species production and potentiates apoptosis induction by the antitumor drugs arsenic trioxide and lonidamine in human myeloid leukemia cell lines. | The Journal of pharmacology and experimental therapeutics 20101001 |
| Autophagic degradation of an oncoprotein. | Autophagy 20101001 |
| A matter of balance between life and death: targeting reactive oxygen species (ROS)-induced autophagy for cancer therapy. | Autophagy 20101001 |
| Treatment of patients with acute promyelocytic leukemia: a consensus statement on risk-adapted approaches to therapy. | Clinical lymphoma, myeloma & leukemia 20101001 |
| Utilization of molecular phenotypes to detect relapse and optimize the management of acute promyelocytic leukemia. | Clinical lymphoma, myeloma & leukemia 20101001 |
| Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein. | Blood 20100930 |
| Murine double minute 2 as a modulator of retroviral restrictions mediated by TRIM5alpha. | Virology 20100930 |
| Autophagy is a critical mechanism for the induction of the antileukemic effects of arsenic trioxide. | The Journal of biological chemistry 20100924 |
| Stathmin is involved in arsenic trioxide-induced apoptosis in human cervical cancer cell lines via PI3K linked signal pathway. | Cancer biology & therapy 20100915 |
| Subchronic exposure to arsenic trioxide-induced oxidative DNA damage in kidney tissue of mice. | Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20100901 |
| Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-XL and survivin. | Medical oncology (Northwood, London, England) 20100901 |
| Down-regulation of heat shock protein 70 improves arsenic trioxide and 17-DMAG effects on constitutive signal transducer and activator of transcription 3 activity. | Cancer chemotherapy and pharmacology 20100901 |
| The expression of p38, ERK1 and Bax proteins has increased during the treatment of newly diagnosed acute promyelocytic leukemia with arsenic trioxide. | Annals of oncology : official journal of the European Society for Medical Oncology 20100901 |
| Induction of B-chronic lymphocytic leukemia cell apoptosis by arsenic trioxide involves suppression of the phosphoinositide 3-kinase/Akt survival pathway via c-jun-NH2 terminal kinase activation and PTEN upregulation. | Clinical cancer research : an official journal of the American Association for Cancer Research 20100901 |
| Arsenic trioxide cooperates with all trans retinoic acid to enhance mitogen-activated protein kinase activation and differentiation in PML-RARalpha negative human myeloblastic leukemia cells. | Leukemia & lymphoma 20100901 |
| Synergistic cytotoxic effects of arsenic trioxide plus dithiothreitol on mice oral cancer cells. | Anticancer research 20100901 |
| Arsenic trioxide induces down-regulation of gp46 via protein oxidation: proteomics analysis of oxidative modified proteins in As2O3-treated HTLV-1-infected cells. | Die Pharmazie 20100901 |
| CNS relapse in acute promyeloctyic leukemia. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100820 |
| MER1, a novel organic arsenic derivative, has potent PML-RARalpha-independent cytotoxic activity against leukemia cells. | Investigational new drugs 20100801 |
| Successful imatinib and arsenic trioxide combination therapy for sudden onset promyelocytic crisis with t(15;17) in chronic myeloid leukemia. | Leukemia research 20100801 |
| Glutathione depletion enhances arsenic trioxide-induced apoptosis in lymphoma cells through mitochondrial-independent mechanisms. | British journal of haematology 20100801 |
| Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth. | Experimental cell research 20100801 |
| Arsenic trioxide inhibits osteosarcoma cell invasiveness via MAPK signaling pathway. | Cancer biology & therapy 20100801 |
| Arsenic trioxide inhibits DNA methyltransferase and restores expression of methylation-silenced CDKN2B/CDKN2A genes in human hematologic malignant cells. | Oncology reports 20100801 |
| [Effects of STI571 combined with As₂O₃ on proliferation, apoptosis and caspase 3, Bcl-xL expression of K562 cells]. | Zhongguo shi yan xue ye xue za zhi 20100801 |
| [Levels of P27Kip1 expression and apoptosis in HL-60 cells after treatment with TGF-ß1 and/or arsenic trioxide]. | Zhongguo shi yan xue ye xue za zhi 20100801 |
| [Effect of arsenic trioxide on induction of apoptosis in MCL cell line and its possible mechanisms]. | Zhongguo shi yan xue ye xue za zhi 20100801 |
| PML/RARA oxidation and arsenic binding initiate the antileukemia response of As2O3. | Cancer cell 20100713 |
| Arsenic trioxide and ascorbic acid demonstrate promising activity against primary human CLL cells in vitro. | Leukemia research 20100701 |
| Keratin 6 expression correlates to areas of squamous differentiation in multiple independent isolates of As(+3)-induced bladder cancer. | Journal of applied toxicology : JAT 20100701 |
| Arsenic inhibits myogenic differentiation and muscle regeneration. | Environmental health perspectives 20100701 |
| XPC silencing sensitizes glioma cells to arsenic trioxide via increased oxidative damage. | Toxicological sciences : an official journal of the Society of Toxicology 20100701 |
| Novel therapeutic approach to eradicate tyrosine kinase inhibitor resistant chronic myeloid leukemia stem cells. | Cancer science 20100701 |
| [Arsenic trioxide treatment in a patient with recurrent acute promyelocytic leukemia (APL)]. | Anales de pediatria (Barcelona, Spain : 2003) 20100701 |
| Abrogating HSP response augments cell death induced by As2O3 in glioma cell lines. | The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20100701 |
| Combination therapy with arsenic trioxide for hematological malignancies. | Anti-cancer agents in medicinal chemistry 20100701 |
| Arsenic trioxide up-regulates Fas expression in human osteosarcoma cells. | Chinese medical journal 20100701 |
| Arsenic trioxide associated toothache. | Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20100601 |
| Arsenic trioxide inhibits the growth of adriamycin resistant osteosarcoma cells through inducing apoptosis. | Molecular biology reports 20100601 |
| Inhibition of liver x receptor/retinoid X receptor-mediated transcription contributes to the proatherogenic effects of arsenic in macrophages in vitro. | Arteriosclerosis, thrombosis, and vascular biology 20100601 |
| Ascorbic acid improves mitochondrial function in liver of arsenic-treated rat. | Toxicology and industrial health 20100601 |
| Eradication of acute promyelocytic leukemia-initiating cells by PML/RARA-targeting. | International journal of hematology 20100601 |
| Arsenic Trioxide overcomes cell adhesion-mediated drug resistance through down-regulating the expression of beta(1)-integrin in K562 chronic myelogenous leukemia cell line. | Leukemia & lymphoma 20100601 |
| Synergistic antiproliferative effect of arsenic trioxide combined with bortezomib in HL60 cell line and primary blasts from patients affected by myeloproliferative disorders. | Cancer genetics and cytogenetics 20100601 |
| A phase I study of 5-fluorouracil/leucovorin and arsenic trioxide for patients with refractory/relapsed colorectal carcinoma. | Clinical cancer research : an official journal of the American Association for Cancer Research 20100601 |
| [Role of Survivin gene on the apoptosis of adenoid cystic carcinoma-2 cells induced by arsenic trioxide]. | Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology 20100601 |
| Arsenic trioxide-dependent activation of thousand-and-one amino acid kinase 2 and transforming growth factor-beta-activated kinase 1. | Molecular pharmacology 20100501 |
| Curcumin supplementation protects from genotoxic effects of arsenic and fluoride. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100501 |
| Differential role of cathepsins B and L in autophagy-associated cell death induced by arsenic trioxide in U87 human glioblastoma cells. | Biological chemistry 20100501 |
| Treatment of therapy related acute promyelocytic leukemia with the combination of all trans retinoic acid and arsenic trioxide without chemotherapy: a series of three patients. | Leukemia & lymphoma 20100501 |
| All-trans retinoic acid and arsenic rescue patients with acute promyelocytic leukemia from a potential 'perfect storm'. | Leukemia & lymphoma 20100501 |
| The effects of arsenic trioxide on DNA synthesis and genotoxicity in human colon cancer cells. | International journal of environmental research and public health 20100501 |
| Arsenic trioxide modulates DNA synthesis and apoptosis in lung carcinoma cells. | International journal of environmental research and public health 20100501 |
| [Three different drug interaction mathematical models used to evaluate the cytotoxicity of SAHA and arsenic trioxide in combination]. | Yao xue xue bao = Acta pharmaceutica Sinica 20100501 |
| Blockage of JNK pathway enhances arsenic trioxide-induced apoptosis in human keratinocytes. | Toxicology and applied pharmacology 20100415 |
| VDAC1 cysteine residues: topology and function in channel activity and apoptosis. | The Biochemical journal 20100414 |
| Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML. | Science (New York, N.Y.) 20100409 |
| Syk is a novel target of arsenic trioxide (ATO) and is involved in the toxic effect of ATO in human neutrophils. | Toxicology in vitro : an international journal published in association with BIBRA 20100401 |
| Phosphatidylserine exposure and procoagulant activity in acute promyelocytic leukemia. | Journal of thrombosis and haemostasis : JTH 20100401 |
| Arsenic trioxide induces endoplasmic reticulum stress-related events in neutrophils. | International immunopharmacology 20100401 |
| Anti-miR-21 oligonucleotide sensitizes leukemic K562 cells to arsenic trioxide by inducing apoptosis. | Cancer science 20100401 |
| External auditory canal and middle ear relapse of acute promyelocytic leukemia treated with arsenic trioxide: case report and review of the literature. | Journal of pediatric hematology/oncology 20100401 |
| Combination treatment with arsenic trioxide and irradiation enhances cell-killing effects in human fibrosarcoma cells in vitro and in vivo through induction of both autophagy and apoptosis. | Autophagy 20100401 |
| Genistein synergizes with arsenic trioxide to suppress human hepatocellular carcinoma. | Cancer science 20100401 |
| [Arsenic trioxide reverses hypermethylation of p16 and activates its transcription in malignant lymphoma cell line CA46]. | Zhongguo shi yan xue ye xue za zhi 20100401 |
| Arsenic trioxide suppresses thymidylate synthase in 5-FU-resistant colorectal cancer cell line HT29 In Vitro re-sensitizing cells to 5-FU. | Anticancer research 20100401 |
| Arsenic trioxide induces the apoptosis in bone marrow mesenchymal stem cells by intracellular calcium signal and caspase-3 pathways. | Toxicology letters 20100315 |
| Arsenic trioxide induces the apoptosis in vascular smooth muscle cells via increasing intracellular calcium and ROS formation. | Molecular biology reports 20100301 |
| Traditional Chinese medicines (TCMs) for molecular targeted therapies of tumours. | Current drug discovery technologies 20100301 |
| Acute promyelocytic leukemia: what are the treatment options? | Expert opinion on pharmacotherapy 20100301 |
| Single cycle of arsenic trioxide-based consolidation chemotherapy spares anthracycline exposure in the primary management of acute promyelocytic leukemia. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100220 |
| Arsenic-trioxide-induced apoptosis of chronic lymphocytic leukemia cells. | International journal of laboratory hematology 20100201 |
| Enhancement of arsenic trioxide cytotoxicity by dietary isothiocyanates in human leukemic cells via a reactive oxygen species-dependent mechanism. | Leukemia research 20100201 |
| Arsenic trioxide-induced apoptosis of Hep-2 cell line through modulating intracellular glutathione (GSH) level. | Auris, nasus, larynx 20100201 |
| Growth-inhibiting effects of arsenic trioxide plus epigenetic therapeutic agents on leukemia cell lines. | Leukemia & lymphoma 20100201 |
| Arsenic trioxide-mediated antiplatelet activity: pivotal role of the phospholipase C gamma 2-protein kinase C-p38 MAPK cascade. | Translational research : the journal of laboratory and clinical medicine 20100201 |
| [Correlation between mTOR signaling transduction pathway and arsenic trioxide response]. | Zhongguo shi yan xue ye xue za zhi 20100201 |
| Synergistic mitosis-arresting effects of arsenic trioxide and paclitaxel on human malignant lymphocytes. | Chemico-biological interactions 20100105 |
| Enhanced antimyeloma cytotoxicity by the combination of arsenic trioxide and bortezomib is further potentiated by p38 MAPK inhibition. | Leukemia research 20100101 |
| Mobilization of PML/RARalpha negative peripheral blood stem cells with a combination of G-CSF and CXCR4 blockade in relapsed acute promyelocytic leukemia pre-treated with arsenic trioxide. | Haematologica 20100101 |
| Effects of arsenic trioxide on cell death, reactive oxygen species and glutathione levels in different cell types. | International journal of molecular medicine 20100101 |
| Different pathways are involved in arsenic-trioxide-induced cell proliferation and growth inhibition in human keratinocytes. | Skin pharmacology and physiology 20100101 |
| Successful post-remission therapy with a combination of all-trans retinoic acid and arsenic trioxide in an elderly Japanese patient newly diagnosed with acute promyelocytic leukemia. | International journal of hematology 20100101 |
| Gangrenous cheilitis associated with all-trans retinoic acid therapy for acute promyelocytic leukemia. | International journal of hematology 20100101 |
| Potent reducing effects of vitamin D3 on the frequency of apoptosis induced by arsenic trioxide in NB4 cell line. | Archives of Iranian medicine 20100101 |
| Acute promyelocytic leukemia: a paradigm for differentiation therapy. | Cancer treatment and research 20100101 |
| [Apoptosis of NB4 cells induced by Tanshinone II A combined with arsenic trioxide]. | Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20100101 |
| Arsenic trioxide and promyelocytic leukemia protein-adenovirus synergistically inhibit in vitro and in vivo growth of a hepatoma cell line. | Oncology research 20100101 |
| The conformation change of Bcl-2 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in SGC7901 human gastric cancer cells. | World journal of surgical oncology 20100101 |
| Sweet fruit from a poisonous kiss. | Journal of hematology & oncology 20100101 |
| JAB1 expression is associated with inverse expression of p27(kip1) in hepatocellular carcinoma. | Hepato-gastroenterology 20100101 |
| The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel. | BMC medical genomics 20100101 |
| Basic mechanisms of arsenic trioxide (ATO)-induced apoptosis in human leukemia (HL-60) cells. | Journal of hematology & oncology 20100101 |
| Protection effect of taurine on nitrosative stress in the mice brain with chronic exposure to arsenic. | Journal of biomedical science 20100101 |
| [Recurrences of acute promyelocytic leukemia in children: experience with arsenic trioxide therapy and autologous hematopoietic cell transplantation]. | Terapevticheskii arkhiv 20100101 |
| Arsenic trioxide induces apoptosis in uveal melanoma cells through the mitochondrial pathway. | The American journal of Chinese medicine 20100101 |
| L-type calcium current (ICa,L) and inward rectifier potassium current (IK1) are involved in QT prolongation induced by arsenic trioxide in rat. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101 |
| Arsenic trioxide sensitizes cancer stem cells to chemoradiotherapy. A new approach in the treatment of inoperable glioblastoma multiforme. | Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20100101 |
| Chemokine induction by all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia: triggering the differentiation syndrome. | Blood 20091224 |
| How I treat acute promyelocytic leukemia. | Blood 20091210 |
| Arsenic induces cell apoptosis in cultured osteoblasts through endoplasmic reticulum stress. | Toxicology and applied pharmacology 20091201 |
| Arsenic trioxide and cisplatin synergism increase cytotoxicity in human ovarian cancer cells: therapeutic potential for ovarian cancer. | Cancer science 20091201 |
| Berbamine, a novel nuclear factor kappaB inhibitor, inhibits growth and induces apoptosis in human myeloma cells. | Acta pharmacologica Sinica 20091201 |
| Redox-related antimelanoma activity of ATN-224. | Melanoma research 20091201 |
| Modulation of arsenic trioxide-induced apoptosis by genistein and functionally related agents in U937 human leukaemia cells. Regulation by ROS and mitogen-activated protein kinases. | Chemico-biological interactions 20091110 |
| Antimony-trioxide- and arsenic-trioxide-induced apoptosis in myelogenic and lymphatic cell lines, recruitment of caspases, and loss of mitochondrial membrane potential are enhanced by modulators of the cellular glutathione redox system. | Annals of hematology 20091101 |
| Effect of aqueous extracts of black and green teas in arsenic-induced toxicity in rabbits. | Phytotherapy research : PTR 20091101 |
| Modulation of p53, c-fos, RARE, cyclin A, and cyclin D1 expression in human leukemia (HL-60) cells exposed to arsenic trioxide. | Molecular and cellular biochemistry 20091101 |
| Arsenic trioxide induces apoptosis and G2/M phase arrest by inducing Cbl to inhibit PI3K/Akt signaling and thereby regulate p53 activation. | Cancer letters 20091101 |
| Three epigenetic drugs up-regulate homeobox gene Rhox5 in cancer cells through overlapping and distinct molecular mechanisms. | Molecular pharmacology 20091101 |
| Beneficial and adverse effects of molecularly targeted therapies for acute promyelocytic leukemia in central nervous system. | CNS & neurological disorders drug targets 20091101 |
| Acute promyelocytic leukemia in childhood. | Current oncology reports 20091101 |
| Arsenic trioxide as first-line treatment for acute promyelocytic leukemia. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20091101 |
| [Arsenic trioxide in combination with all-trans retinoic acid for acute promyelocytic leukemia: a systematic review and meta-analysis]. | Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20091101 |
| Effects of arsenic trioxide on the cerulein-induced AR42J cells and its gene regulation. | Pancreas 20091001 |
| Arsenic trioxide inhibits metastatic potential of mouse hepatoma H22 cells in vitro and in vivo. | Hepatobiliary & pancreatic diseases international : HBPD INT 20091001 |
| The effect of MAPK inhibitors on arsenic trioxide-treated Calu-6 lung cells in relation to cell death, ROS and GSH levels. | Anticancer research 20091001 |
| [Effect of arsenic pentaoxide on proliferation and apoptosis of human umbilical vein endothelial cell]. | Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20091001 |
| [Comparison of efficacy and adverse effects between arsenic trioxide and all-trans retinoic acid in patients with acute promyelocytic leukemia]. | Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20091001 |
| [Induced RAS association domain family gene 1A gene expression by arsenic trioxide in nasopharyngeal carcinoma cell]. | Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 20091001 |
| Arsenic trioxide downregulates the expression of annexin II in bone marrow cells from patients with acute myelogenous leukemia. | Chinese medical journal 20090905 |
| [Efficacy of arsenic trioxide for acute promyelocytic leukemia: a systematic review and meta-analysis]. | Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20090901 |
| Arsenic trioxide modulates the central snail neuron action potential. | Journal of the Formosan Medical Association = Taiwan yi zhi 20090901 |
| Arsenic trioxide inhibits the growth of human lung cancer cell lines via cell cycle arrest and induction of apoptosis at both normoxia and hypoxia. | Toxicology and industrial health 20090901 |
| [Apoptosis of MR2 cells induced by Tanshinone II A combined with arsenic trioxide]. | Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20090901 |
| [Retrospective analysis of 76 children with acute promyelocytic leukemia]. | Zhonghua er ke za zhi = Chinese journal of pediatrics 20090901 |
| Arsenic trioxide and lead acetate induce apoptosis in adult rat hepatic stem cells. | Cell biology and toxicology 20090801 |
| Folic acid or combination of folic acid and vitamin B(12) prevents short-term arsenic trioxide-induced systemic and mitochondrial dysfunction and DNA damage. | Environmental toxicology 20090801 |
| The efficacy of arsenic trioxide for the treatment of relapsed and refractory multiple myeloma: a systematic review. | Cancer treatment reviews 20090801 |
| Prospective minimal residual disease monitoring to predict relapse of acute promyelocytic leukemia and to direct pre-emptive arsenic trioxide therapy. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090801 |
| Effect of colloidal gold nanoparticles on cell interface and their enhanced intracellular uptake of arsenic trioxide in leukemia cancer cells. | Journal of nanoscience and nanotechnology 20090801 |
| Downregulation of the c-MYC target gene, peroxiredoxin III, contributes to arsenic trioxide-induced apoptosis in acute promyelocytic leukemia. | International journal of cancer 20090715 |
| Apoptosis induction by (+)alpha-tocopheryl succinate in the absence or presence of all-trans retinoic acid and arsenic trioxide in NB4, NB4-R2 and primary APL cells. | Leukemia research 20090701 |
| Subchronic exposure to arsenic decreased Sdha expression in the brain of mice. | Neurotoxicology 20090701 |
| Use of arsenic trioxide in secondary acute promyelocytic leukemia developing after treatment of multiple sclerosis with mitoxantrone. | Leukemia & lymphoma 20090701 |
| The overexpression of multidrug resistance-associated proteins and gankyrin contribute to arsenic trioxide resistance in liver and gastric cancer cells. | Oncology reports 20090701 |
| Folate-mediated intracellular drug delivery increases the anticancer efficacy of nanoparticulate formulation of arsenic trioxide. | Molecular cancer therapeutics 20090701 |
| Effect of arsenic trioxide on renal functions and its modulation by Curcuma aromatica leaf extract in albino rat. | Journal of environmental biology 20090701 |
| Enhancement of esculetin on arsenic trioxide-provoked apoptosis in human leukemia U937 cells. | Chemico-biological interactions 20090615 |
| Role of SUMO in RNF4-mediated promyelocytic leukemia protein (PML) degradation: sumoylation of PML and phospho-switch control of its SUMO binding domain dissected in living cells. | The Journal of biological chemistry 20090612 |
| Gamma-glutamyltransferase-dependent resistance to arsenic trioxide in melanoma cells and cellular sensitization by ascorbic acid. | Free radical biology & medicine 20090601 |
| Redox-sensitive regulation of gene expression in human primary macrophages exposed to inorganic arsenic. | Journal of cellular biochemistry 20090601 |
| Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells. | Journal of proteome research 20090601 |
| Arsenic trioxide suppresses paclitaxel-induced mitotic arrest. | Cell proliferation 20090601 |
| Synergistic interaction between tetra-arsenic oxide and paclitaxel in human cancer cells in vitro. | International journal of oncology 20090601 |
| Arsenic trioxide attenuated the rejection of major histocompatibility complex fully-mismatched cardiac allografts in mice. | Transplantation proceedings 20090601 |
| [Influence of As(2)O(3) on proteasome beta(1)-subunit in NB4 cells]. | Zhongguo shi yan xue ye xue za zhi 20090601 |
| [Effect of arsenic trioxide on apoptosis in lymphoblastoid Raji cell line with relation to expression of mcl-1 gene]. | Zhongguo shi yan xue ye xue za zhi 20090601 |
| [Effect of arsenic trioxide combined with adriamycin on the proliferation and apoptosis of human lymphoma cells]. | Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20090601 |
| [As2O3 induces demethylation and up-regulates transcription of SHP-1 gene in human lymphoma cell line T2 cells]. | Zhonghua zhong liu za zhi [Chinese journal of oncology] 20090601 |
| [Study on the mechanism of arsenic trioxide inhibiting NB4 cells proliferation]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20090601 |
| Hematopoietic stem cell differentiation affects expression and function of MRP4 (ABCC4), a transport protein for signaling molecules and drugs. | International journal of cancer 20090515 |
| Reactive oxygen species are not required for an arsenic trioxide-induced antioxidant response or apoptosis. | The Journal of biological chemistry 20090508 |
| Direct toxicity assessment of toxic chemicals with electrochemical method. | Analytica chimica acta 20090508 |
| Induction of iodide uptake in transformed thyrocytes: a compound screening in cell lines. | European journal of nuclear medicine and molecular imaging 20090501 |
| Combination treatment with arsenic trioxide and irradiation enhances autophagic effects in U118-MG cells through increased mitotic arrest and regulation of PI3K/Akt and ERK1/2 signaling pathways. | Autophagy 20090501 |
| A novel combination therapy with arsenic trioxide and parthenolide against pancreatic cancer cells. | Pancreas 20090501 |
| Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line. | Molecular cancer therapeutics 20090501 |
| [Effect of arsenic trioxide combined with aspirin on the growth of human gastric adenocarcinoma graft in nude mice]. | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20090501 |
| Radiation-induced cathepsin S is involved in radioresistance. | International journal of cancer 20090415 |
| Heat shock protein inhibitors, 17-DMAG and KNK437, enhance arsenic trioxide-induced mitotic apoptosis. | Toxicology and applied pharmacology 20090415 |
| Antitumor activity of arsenic trioxide on retinoblastoma: cell differentiation and apoptosis depending on arsenic trioxide concentration. | Investigative ophthalmology & visual science 20090401 |
| [Role of P27(Kip1) and TGF-beta1 in APL cell apoptosis induced by As(2)O(3)]. | Zhongguo shi yan xue ye xue za zhi 20090401 |
| Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia. | Proceedings of the National Academy of Sciences of the United States of America 20090303 |
| Phase II study of arsenic trioxide and ascorbic acid for relapsed or refractory lymphoid malignancies: a Wisconsin Oncology Network study. | Hematological oncology 20090301 |
| Incidence and prophylaxis of venous thromboembolic events in multiple myeloma patients receiving immunomodulatory therapy. | Thrombosis research 20090301 |
| Combination of DNA methylation inhibitor 5-azacytidine and arsenic trioxide has synergistic activity in myeloma. | European journal of haematology 20090301 |
| Increased aquaglyceroporin 9 expression disrupts arsenic resistance in human lung cancer cells. | Toxicology in vitro : an international journal published in association with BIBRA 20090301 |
| Arsenic trioxide inhibits hepatitis C virus RNA replication through modulation of the glutathione redox system and oxidative stress. | Journal of virology 20090301 |
| Co-application of arsenic trioxide (As2O3) and cisplatin (CDDP) on human SY-5Y neuroblastoma cells has differential effects on the intracellular calcium concentration ([Ca2+]i) and cytotoxicity. | Neurotoxicology 20090301 |
| Inhibition of androgen receptor transcriptional activity as a novel mechanism of action of arsenic. | Molecular endocrinology (Baltimore, Md.) 20090301 |
| Interaction between arsenic trioxide and human primary cells: emphasis on human cells of myeloid origin. | Inflammation & allergy drug targets 20090301 |
| Survival after a massive overdose of arsenic trioxide. | Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 20090301 |
| Differentiation therapy of acute myeloid leukemia: past, present and future. | Current opinion in hematology 20090301 |
| [Effect of As2O3 on demethylation of SHP-1 gene in human lymphoma cell line T2]. | Ai zheng = Aizheng = Chinese journal of cancer 20090301 |
| [Clinical study on the fibrinolytic activity in patients with acute promyelocytic leukemia]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20090301 |
| Tannic acid-induced apoptosis and -enhanced sensitivity to arsenic trioxide in human leukemia HL-60 cells. | Leukemia research 20090201 |
| Effective treatment of acute promyelocytic leukemia with all-trans-retinoic acid, arsenic trioxide, and gemtuzumab ozogamicin. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090201 |
| Global effects of inorganic arsenic on gene expression profile in human macrophages. | Molecular immunology 20090201 |
| [Effect of As(2)O(3) on expressions of COX-2 and matrix metalloproteinases in SGC7901 and K562 cells]. | Zhongguo shi yan xue ye xue za zhi 20090201 |
| [P27(Kip1), cyclin E and endogenous TGF-beta1 changes in apoptosis of NB4 cells induced by As(2)O(3) and/or TGF-beta1 and their significance]. | Zhongguo shi yan xue ye xue za zhi 20090201 |
| [The significance of combined therapy of arsenic trioxide and all-trans retinoic acid in treating acute promyelocytic leukemia]. | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20090201 |
| [Effects of arsenic trioxide on human coronary smooth muscle cells: experiment in vitro]. | Zhonghua yi xue za zhi 20090113 |
| Curing APL: differentiation or destruction? | Cancer cell 20090106 |
| Arsenic trioxide-induced growth arrest of human hepatocellular carcinoma cells involving FOXO3a expression and localization. | Medical oncology (Northwood, London, England) 20090101 |
| Use of all-trans retinoic acid in combination with arsenic trioxide for remission induction in patients with newly diagnosed acute promyelocytic leukemia and for consolidation/maintenance in CR patients. | Acta haematologica 20090101 |
| Protein kinase C is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in human bladder cancer cells. | Urologia internationalis 20090101 |
| Possible roles of a tumor suppressor gene PIG11 in hepatocarcinogenesis and As2O3-induced apoptosis in liver cancer cells. | Journal of gastroenterology 20090101 |
| Arsenic down-regulates the expression of Camk4, an important gene related to cerebellar LTD in mice. | Neurotoxicology and teratology 20090101 |
| [Immunofluorescence examination of CK-13 expression in cell line KB differentiated by all-trans retinoic acid or As2 O3]. | Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology 20090101 |
| [Arsenic trioxide inhibits cell growth in imatinib-resistant bcr-abl mutant cell lines in vitro]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20090101 |
| Arsenic trioxide exerts synergistic effects with cisplatin on non-small cell lung cancer cells via apoptosis induction. | Journal of experimental & clinical cancer research : CR 20090101 |
| Thermochemotherapy effect of nanosized As2O3/Fe3O4 complex on experimental mouse tumors and its influence on the expression of CD44v6, VEGF-C and MMP-9. | BMC biotechnology 20090101 |
| TRIM5alpha and TRIMCyp form apparent hexamers and their multimeric state is not affected by exposure to restriction-sensitive viruses or by treatment with pharmacological inhibitors. | Retrovirology 20090101 |
| Evaluation of adverse cardiac effects induced by arsenic trioxide, a potent anti-APL drug. | Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20090101 |
| Supplements for immune enhancement in hematologic malignancies. | Hematology. American Society of Hematology. Education Program 20090101 |
| Omega-3 and omega-6 polyunsaturated fatty acids enhance arsenic trioxide efficacy in arsenic trioxide-resistant leukemic and solid tumor cells. | Oncology research 20090101 |
| The effects of ultrasound and arsenic trioxide on neurogliocytoma cells and secondary activation of macrophages. | Tumori 20090101 |
| Inhibition of mitochondrial protein translation sensitizes melanoma cells to arsenic trioxide cytotoxicity via a reactive oxygen species dependent mechanism. | Cancer chemotherapy and pharmacology 20081201 |
| Glutathione regulation in arsenic-induced porcine aortic endothelial cells. | Toxicology in vitro : an international journal published in association with BIBRA 20081201 |
| Arsenic trioxide phosphorylates c-Fos to transactivate p21(WAF1/CIP1) expression. | Toxicology and applied pharmacology 20081201 |
| New drugs in multiple myeloma: mechanisms of action and phase I/II clinical findings. | The Lancet. Oncology 20081201 |
| Arsenic trioxide with ascorbic acid and high-dose melphalan: results of a phase II randomized trial. | Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20081201 |
| What is the role of arsenic in newly diagnosed APL? | Best practice & research. Clinical haematology 20081201 |
| Arsenic trioxide in patients with adenocarcinoma of the pancreas refractory to gemcitabine: a phase II trial of the University of Chicago Phase II Consortium. | American journal of clinical oncology 20081201 |
| Transcriptome and proteome analyses of drug interactions with natural products. | Current drug metabolism 20081201 |
| Arsenic trioxide (As2O3) inhibits expression of estrogen receptor-alpha through regulation of the mitogen-activated protein kinase (MAPK) pathway in endometrial cancer cells. | Reproductive sciences (Thousand Oaks, Calif.) 20081201 |
| [Synergistic effects of VPA and As2O3 on Molt-4 cells in vitro and its possible mechanisms]. | Zhongguo shi yan xue ye xue za zhi 20081201 |
| [Effect of arsenic trioxide on vascular endothelial growth factor-C and its receptor (VEGFR-3) in nude mice with gastric cancer]. | Zhongguo shi yan xue ye xue za zhi 20081201 |
| [Effects of As2O3 on apoptosis and Bcl-2/Bax expression of rat spermatogenic cells]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081201 |
| Inhibition of interleukin-13 gene expression in T cells through GATA-3 pathway by arsenic trioxide. | Chinese medical journal 20081120 |
| Arsenic trioxide mutational spectrum analysis in the mouse lymphoma assay. | Mutation research 20081110 |
| Detoxification system for inorganic arsenic: transformation of As2O3 into TMAO by vitamin B12 derivatives and conversion of TMAO into arsenobetaine. | Chemical communications (Cambridge, England) 20081107 |
| Arsenic trioxide and 2-methoxyestradiol reduce beta-catenin accumulation after proteasome inhibition and enhance the sensitivity of myeloma cells to Bortezomib. | Leukemia research 20081101 |
| PML/RARalpha fusion protein mediates the unique sensitivity to arsenic cytotoxicity in acute promyelocytic leukemia cells: Mechanisms involve the impairment of cAMP signaling and the aberrant regulation of NADPH oxidase. | Journal of cellular physiology 20081101 |
| Determinants of cerebrospinal fluid arsenic concentration in patients with acute promyelocytic leukemia on oral arsenic trioxide therapy. | Blood 20081101 |
| Acute arsenic trioxide ant bait ingestion by toddlers. | Clinical toxicology (Philadelphia, Pa.) 20081101 |
| Arsenic trioxide and low-dose cytarabine in older patients with untreated acute myeloid leukemia, excluding acute promyelocytic leukemia. | Cancer 20081101 |
| [Correlation of cell cycle alteration to SOCS-1 gene demethylation induced by arsenic trioxide in myeloma cell lines]. | Ai zheng = Aizheng = Chinese journal of cancer 20081101 |
| Antitumor effects of arsenic trioxide in transformed human thyroid cells. | Thyroid : official journal of the American Thyroid Association 20081101 |
| As2O3 toxicity in rat hepatocytes: manifestation of caspase-mediated apoptosis. | Toxicology and industrial health 20081101 |
| [In vitro effect of bortezomib alone or in combination with harringtonine or arsenic trioxide on proliferation and apoptosis of multidrug resistant leukemia cells]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20081101 |
| Arsenic trioxide inhibits the growth of Calu-6 cells via inducing a G2 arrest of the cell cycle and apoptosis accompanied with the depletion of GSH. | Cancer letters 20081018 |
| The redox state of the lung cancer microenvironment depends on the levels of thioredoxin expressed by tumor cells and affects tumor progression and response to prooxidants. | International journal of cancer 20081015 |
| Requirement of a functional spindle checkpoint for arsenite-induced apoptosis. | Journal of cellular biochemistry 20081015 |
| The thioredoxin system mediates redox-induced cell death in human colon cancer cells: implications for the mechanism of action of anticancer agents. | Cancer research 20081015 |
| The role of p38 MAPK and JNK in Arsenic trioxide-induced mitochondrial cell death in human cervical cancer cells. | Journal of cellular physiology 20081001 |
| A novel arsenical has antitumor activity toward As2O3-resistant and MRP1/ABCC1-overexpressing cell lines. | Leukemia 20081001 |
| [Changes of activity and expression of protein phosphatase type 2A during the apoptosis of NB4 and MR2 cells induced by arsenic trioxide]. | Zhongguo shi yan xue ye xue za zhi 20081001 |
| [Arsenic trioxide induces socs-1 gene demethylation in myeloma cell lines]. | Zhongguo shi yan xue ye xue za zhi 20081001 |
| Catalase activity and arsenic sensitivity in acute leukemia. | Leukemia & lymphoma 20081001 |
| [Mechanism of arsenic trioxide induced apoptosis in cultured human lens epithelium cells]. | [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20081001 |
| N-(beta-Elemene-13-yl)tryptophan methyl ester induces apoptosis in human leukemia cells and synergizes with arsenic trioxide through a hydrogen peroxide dependent pathway. | Cancer letters 20080928 |
| Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways. | Blood 20080915 |
| [Selected mechanisms of the therapeutic effect of arsenic trioxide in cancer treatment]. | Postepy higieny i medycyny doswiadczalnej (Online) 20080909 |
| Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. | Molecular biology reports 20080901 |
| A combination of sulindac and arsenic trioxide synergistically induces apoptosis in human lung cancer H1299 cells via c-Jun NH2-terminal kinase-dependent Bcl-xL phosphorylation. | Lung cancer (Amsterdam, Netherlands) 20080901 |
| Genistein selectively potentiates arsenic trioxide-induced apoptosis in human leukemia cells via reactive oxygen species generation and activation of reactive oxygen species-inducible protein kinases (p38-MAPK, AMPK). | International journal of cancer 20080901 |
| Inhibition on LS-174T cell growth and activity of telomerase in vitro and in vivo by arsenic trioxide. | Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20080901 |
| New drugs in multiple myeloma. | Current opinion in supportive and palliative care 20080901 |
| Role of p38 MAPK and JNK in enhanced cervical cancer cell killing by the combination of arsenic trioxide and ionizing radiation. | Oncology reports 20080901 |
| Induction of apoptosis in arsenic trioxide-treated lung cancer A549 cells by buthionine sulfoximine. | Molecules and cells 20080831 |
| Down-regulation of beta1,4GalT V at protein level contributes to arsenic trioxide-induced glioma cell apoptosis. | Cancer letters 20080818 |
| Arsenic trioxide down-regulates antiapoptotic genes and induces cell death in mycosis fungoides tumors in a mouse model. | Annals of oncology : official journal of the European Society for Medical Oncology 20080801 |
| Combination brings long-term remission in acute promyelocytic leukemia refractory for both all-trans retinoic acid and arsenic trioxide. | European journal of haematology 20080801 |
| Retrospective analysis of 65 Chinese children with acute promyelocytic leukemia: a single center experience. | Pediatric blood & cancer 20080801 |
| Arsenic trioxide, arsenic pentoxide, and arsenic iodide inhibit human keratinocyte proliferation through the induction of apoptosis. | The Journal of pharmacology and experimental therapeutics 20080801 |
| Arsenic trioxide impairs spermatogenesis via reducing gene expression levels in testosterone synthesis pathway. | Chemical research in toxicology 20080801 |
| Combination treatment with arsenic trioxide and sulindac enhances apoptotic cell death in lung cancer cells via activation of oxidative stress and mitogen-activated protein kinases. | Oncology reports 20080801 |
| Acute promyelocytic leukemia: recent advances in diagnosis and management. | Seminars in oncology 20080801 |
| [Synergistic effects of arsenic trioxide and proteasome inhibitor bortezomib on apoptosis induction in Raji cell line]. | Zhongguo shi yan xue ye xue za zhi 20080801 |
| Suppression of arsenic trioxide-induced apoptosis in HeLa cells by N-acetylcysteine. | Molecules and cells 20080731 |
| Arsenic trioxide augments Chk2/p53-mediated apoptosis by inhibiting oncogenic Wip1 phosphatase. | The Journal of biological chemistry 20080704 |
| All-trans-retinoic acid and arsenic trioxide as initial therapy for acute promyelocytic leukemia. | Pediatric blood & cancer 20080701 |
| JWA is required for arsenic trioxide induced apoptosis in HeLa and MCF-7 cells via reactive oxygen species and mitochondria linked signal pathway. | Toxicology and applied pharmacology 20080701 |
| Acute myeloid leukemia in the elderly: conventional and novel treatment approaches. | Blood reviews 20080701 |
| Mandibular bone necrosis caused by use of arsenic paste during endodontic treatment: two case reports. | International endodontic journal 20080701 |
| Death-associated protein 5 (DAP5/p97/NAT1) contributes to retinoic acid-induced granulocytic differentiation and arsenic trioxide-induced apoptosis in acute promyelocytic leukemia. | Apoptosis : an international journal on programmed cell death 20080701 |
| Sulindac enhances arsenic trioxide-mediated apoptosis by inhibition of NF-kappaB in HCT116 colon cancer cells. | Oncology reports 20080701 |
| Enhancement of arsenic trioxide-induced apoptosis in HeLa cells by diethyldithiocarbamate or buthionine sulfoximine. | International journal of oncology 20080701 |
| Expression of Dlk1 gene in myelodysplastic syndrome determined by microarray, and its effects on leukemia cells. | International journal of molecular medicine 20080701 |
| Arsenic trioxide and auranofin inhibit selenoprotein synthesis: implications for chemotherapy for acute promyelocytic leukaemia. | British journal of pharmacology 20080701 |
| Arsenic and old lace: novel approaches in elderly patients with acute myeloid leukemia. | Seminars in hematology 20080701 |
| The expanding role of arsenic in acute promyelocytic leukemia. | Seminars in hematology 20080701 |
| [Can As2O3 improve the prognosis of childhood acute promyelocytic leukemia?--A single center experience]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20080701 |
| PML targeting eradicates quiescent leukaemia-initiating cells. | Nature 20080619 |
| PML enhances the regulation of p53 by CK1 in response to DNA damage. | Oncogene 20080612 |
| Intracellular GSH level is a factor in As4.1 juxtaglomerular cell death by arsenic trioxide. | Journal of cellular biochemistry 20080601 |
| Arsenic trioxide inhibits ATRA-induced prostaglandin E2 and cyclooxygenase-1 in NB4 cells, a model of acute promyelocytic leukemia. | Leukemia 20080601 |
| Apoptosis in arsenic trioxide-treated Calu-6 lung cells is correlated with the depletion of GSH levels rather than the changes of ROS levels. | Journal of cellular biochemistry 20080601 |
| Induction of NKG2D ligands and subsequent enhancement of NK cell-mediated lysis of cancer cells by arsenic trioxide. | Journal of immunotherapy (Hagerstown, Md. : 1997) 20080601 |
| Arsenic trioxide decreases AKT protein in a caspase-dependent manner. | Molecular cancer therapeutics 20080601 |
| [Arsenic trioxide induced apoptosis in retinoblastoma cells in vitro and its possible mechanism]. | Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20080601 |
| Quercetin decreases intracellular GSH content and potentiates the apoptotic action of the antileukemic drug arsenic trioxide in human leukemia cell lines. | Biochemical pharmacology 20080515 |
| Acute renal failure, gastrointestinal bleeding, and cardiac arrhythmia after administration of arsenic trioxide for acute promyelocytic leukemia. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080515 |
| Regulation of arsenic trioxide-induced cellular responses by Mnk1 and Mnk2. | The Journal of biological chemistry 20080502 |
| Inhibitory role of TGIF in the As2O3-regulated p21 WAF1/CIP1 expression. | Journal of biomedical science 20080501 |
| Monitoring autophagy in glioblastoma with antibody against isoform B of human microtubule-associated protein 1 light chain 3. | Autophagy 20080501 |
| Arsenic trioxide induces apoptosis preferentially in B-CLL cells of patients with unfavourable prognostic factors including del17p13. | Journal of molecular medicine (Berlin, Germany) 20080501 |
| Resveratrol protects against arsenic trioxide-induced cardiotoxicity in vitro and in vivo. | British journal of pharmacology 20080501 |
| Arsenic trioxide-induced apoptosis in H9c2 cardiomyocytes: implications in cardiotoxicity. | Basic & clinical pharmacology & toxicology 20080501 |
| Inorganic arsenic activates reduced NADPH oxidase in human primary macrophages through a Rho kinase/p38 kinase pathway. | Journal of immunology (Baltimore, Md. : 1950) 20080501 |
| Potentiation of arsenic trioxide cytotoxicity by Parthenolide and buthionine sulfoximine in murine and human leukemic cells. | Cancer chemotherapy and pharmacology 20080401 |
| Alternative pathways of programmed cell death are activated in cells with defective caspase-dependent apoptosis. | Leukemia research 20080401 |
| Redox status of thioredoxin-1 (TRX1) determines the sensitivity of human liver carcinoma cells (HepG2) to arsenic trioxide-induced cell death. | Cell research 20080401 |
| Phase II trial of arsenic trioxide and ascorbic acid with temozolomide in patients with metastatic melanoma with or without central nervous system metastases. | Melanoma research 20080401 |
| SUMOylation of HMGA2: selective destabilization of promyelocytic leukemia protein via proteasome. | Molecular cancer therapeutics 20080401 |
| [Inhibitory effect of sorafenib combined with arsenic trioxide on hepatocellular carcinoma cells]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20080401 |
| In vitro cytogenetic effects of Andrographis paniculata (kalmegh) on arsenic. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20080301 |
| NADPH oxidase-derived reactive oxygen species are responsible for the high susceptibility to arsenic cytotoxicity in acute promyelocytic leukemia cells. | Leukemia research 20080301 |
| Arsenic trioxide induced the apoptosis of laryngeal cancer via down-regulation of survivin mRNA. | Auris, nasus, larynx 20080301 |
| As2O3-induced oxidative stress and cycle progression in a human intestinal epithelial cell line (Caco-2). | Toxicology in vitro : an international journal published in association with BIBRA 20080301 |
| QT prolongation: a case of arsenical pericardial and pleural effusion. | Cardiovascular toxicology 20080301 |
| Safety and efficacy of arsenic trioxide for patients with advanced metastatic melanoma. | Cancer 20080301 |
| Arsenic trioxide: safety issues and their management. | Acta pharmacologica Sinica 20080301 |
| Acute promyelocytic leukemia: from highly fatal to highly curable. | Blood 20080301 |
| [Effects of arsenic trioxide on apoptosis and proliferation of human lung cancer cells under hypoxia]. | Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20080301 |
| [Arsenic trioxide combined with buthionine sulfoximine enhances apoptosis in multidrug-resistant human leukemia K562/ADM cells in vitro]. | Zhonghua zhong liu za zhi [Chinese journal of oncology] 20080301 |
| Glycolytic metabolism confers resistance to combined all-trans retinoic acid and arsenic trioxide-induced apoptosis in HL60rho0 cells. | Leukemia research 20080201 |
| Role of Myc in differentiation and apoptosis in HL60 cells after exposure to arsenic trioxide or all-trans retinoic acid. | Leukemia research 20080201 |
| Arsenic trioxide, thalidomide and retinoid acid combination therapy in higher risk myelodysplastic syndrome patients. | Leukemia research 20080201 |
| Arsenic trioxide induces de novo protein synthesis of annexin-1 in neutrophils: association with a heat shock-like response and not apoptosis. | British journal of haematology 20080201 |
| [Effect of arsenic trioxide combined with bortezomib on proliferation, apoptosis and beta-catenin level in myeloma cell lines]. | Zhongguo shi yan xue ye xue za zhi 20080201 |
| [Effects of vitamin C combined with arsenic trioxide on the apoptosis of Hep-2 cell]. | Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery 20080201 |
| Regulatory effects of mammalian target of rapamycin-mediated signals in the generation of arsenic trioxide responses. | The Journal of biological chemistry 20080125 |
| Analytical artefacts in the speciation of arsenic in clinical samples. | Analytica chimica acta 20080121 |
| Dithiothreitol abrogates the effect of arsenic trioxide on normal rat liver mitochondria and human hepatocellular carcinoma cells. | Toxicology and applied pharmacology 20080115 |
| Dynamic effects of autophagy on arsenic trioxide-induced death of human leukemia cell line HL60 cells. | Acta pharmacologica Sinica 20080101 |
| Insight into the selectivity of arsenic trioxide for acute promyelocytic leukemia cells by characterizing Saccharomyces cerevisiae deletion strains that are sensitive or resistant to the metalloid. | The international journal of biochemistry & cell biology 20080101 |
| Arsenic trioxide sensitizes human glioma cells, but not normal astrocytes, to TRAIL-induced apoptosis via CCAAT/enhancer-binding protein homologous protein-dependent DR5 up-regulation. | Cancer research 20080101 |
| Emodin-induced generation of reactive oxygen species inhibits RhoA activation to sensitize gastric carcinoma cells to anoikis. | Neoplasia (New York, N.Y.) 20080101 |
| Berberine enhances inhibition of glioma tumor cell migration and invasiveness mediated by arsenic trioxide. | BMC cancer 20080101 |
| In vitro arsenic trioxide induces apoptosis in T cells of asthmatic patients by a Bcl-2 related mechanism. | Yao xue xue bao = Acta pharmaceutica Sinica 20080101 |
| Differential effect of ascorbic acid and n-acetyl-L-cysteine on arsenic trioxide-mediated oxidative stress in human leukemia (HL-60) cells. | Journal of biochemical and molecular toxicology 20080101 |
| Comparative efficacy of two microdoses of a potentized homeopathic drug, arsenicum album, to ameliorate toxicity induced by repeated sublethal injections of arsenic trioxide in mice. | Pathobiology : journal of immunopathology, molecular and cellular biology 20080101 |
| Acute encephalopathy following arsenic trioxide for metastatic urothelial carcinoma. | Urologic oncology 20080101 |
| Deletion of Glu155 causes a deficiency of glutathione transferase Omega 1-1 but does not alter sensitivity to arsenic trioxide and other cytotoxic drugs. | The international journal of biochemistry & cell biology 20080101 |
| Augmentation by carnosic acid of apoptosis in human leukaemia cells induced by arsenic trioxide via upregulation of the tumour suppressor PTEN. | The Journal of international medical research 20080101 |
| [Coagulopathy and differentiation syndrome: the main complications of the initial treatment of acute promyelocytic leukemia]. | Vnitrni lekarstvi 20080101 |
| Involvement of protein phosphatase 2A in arsenic trioxide-induced differentiation and apoptosis of NB4 cells. | Methods and findings in experimental and clinical pharmacology 20080101 |
| Curative strategies in acute promyelocytic leukemia. | Hematology. American Society of Hematology. Education Program 20080101 |
| Novel agents in CML therapy: tyrosine kinase inhibitors and beyond. | Hematology. American Society of Hematology. Education Program 20080101 |
| Antiangiogenic therapy in myelodysplastic syndromes: is there a role? | Current hematologic malignancy reports 20080101 |
| Effects of HBV X gene and arsenic trioxide on the expression of p53 in cultured HepG2 cells. | Chinese medical journal 20071220 |
| Cordycepin induced eryptosis in mouse erythrocytes through a Ca2+-dependent pathway without caspase-3 activation. | Archives of toxicology 20071201 |
| Refractory multiple myeloma treated with homoharringtonine: report of two cases. | Annals of hematology 20071201 |
| The PRKAR1A gene is fused to RARA in a new variant acute promyelocytic leukemia. | Blood 20071201 |
| Arsenic trioxide initiates ER stress responses, perturbs calcium signalling and promotes apoptosis in human lens epithelial cells. | Experimental eye research 20071201 |
| Adhesion molecules and Differentiation Syndrome: phenotypic and functional analysis of the effect of ATRA, As2O3, phenylbutyrate, and G-CSF in acute promyelocytic leukemia. | Haematologica 20071201 |
| [Molecular targeting therapy for multiple myeloma]. | Nihon rinsho. Japanese journal of clinical medicine 20071201 |
| [Effect of arsenic trioxide on the expression of apoptosis-related genes in NB4 cells]. | Zhongguo shi yan xue ye xue za zhi 20071201 |
| [Effects of As2O3, dexamethasone and thalidomide on apoptosis and cytoplasmic [Ca2+] of myeloma cell line U266]. | Zhongguo shi yan xue ye xue za zhi 20071201 |
| [Successful cyclosporine treatment for thrombocytopenia after salvage therapy with arsenic trioxide therapy followed by autologous hematopoietic stem cell transplantation in acute promyelocytic leukemia]. | [Rinsho ketsueki] The Japanese journal of clinical hematology 20071201 |
| Gene expression profile of multiple myeloma cell line treated by arsenic trioxide. | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20071201 |
| New data with arsenic trioxide in leukemias and myelodysplastic syndromes. | Clinical lymphoma & myeloma 20071201 |
| Arsenic in the cerebrospinal fluid of a patient receiving arsenic trioxide for relapsed acute promyelocytic leukemia with CNS involvement. | Leukemia research 20071101 |
| Melissoidesin G, a diterpenoid purified from Isodon melissoides, induces leukemic-cell apoptosis through induction of redox imbalance and exhibits synergy with other anticancer agents. | International journal of cancer 20071101 |
| Arsenic trioxide sensitizes promonocytic leukemia cells to TNFalpha-induced apoptosis via p38-MAPK-regulated activation of both receptor-mediated and mitochondrial pathways. | Biochimica et biophysica acta 20071101 |
| [Effects of arsenic trioxide on expressions of vascular endothelial growth factor and P-glycoprotein in multidrug resistant leukemia cell line K562/A02]. | Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20071101 |
| [Research advance of nanometric traditional Chinese herbal drugs for cancer treatment]. | Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20071101 |
| [STI571 enhances the effect of arsenic trioxide and Velcade on bcr/abl+-CD34+ cell proliferation and apoptosis]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20071101 |
| Trolox enhances the anti-lymphoma effects of arsenic trioxide, while protecting against liver toxicity. | Leukemia 20071001 |
| PML-RARalpha inhibitors (ATRA, tamibaroten, arsenic troxide) for acute promyelocytic leukemia. | International journal of clinical oncology 20071001 |
| [Mechanisms underlying the effect of arsenic trioxide on proliferation inhibition and apoptosis induction in myeloma cell line u266]. | Zhongguo shi yan xue ye xue za zhi 20071001 |
| [Effect of bortezomib used alone or in combination with arsenic trioxide on HL-60 cell xenograft in nude mice]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20071001 |
| Low-dose arsenic trioxide sensitizes glucocorticoid-resistant acute lymphoblastic leukemia cells to dexamethasone via an Akt-dependent pathway. | Blood 20070915 |
| A potentized homeopathic drug, Arsenicum Album 200, can ameliorate genotoxicity induced by repeated injections of arsenic trioxide in mice. | Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20070901 |
| Leukemia, an effective model for chemical biology and target therapy. | Acta pharmacologica Sinica 20070901 |
| From dissection of disease pathogenesis to elucidation of mechanisms of targeted therapies: leukemia research in the genomic era. | Acta pharmacologica Sinica 20070901 |
| Arsenic trioxide entered cerebrospinal fluid with the help of mannitol overwhelm the meningeal relapse of acute promyelocytic leukemia. | Haematologica 20070901 |
| [Effects of arsenic trioxide and ATRA on PLZF-RARalpha-positive U937 leukemic cells]. | Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20070901 |
| [Reversal effect and mechanism of arsenic trioxide on multidrug resistance of gastric carcinoma cells SGC7901]. | Yao xue xue bao = Acta pharmaceutica Sinica 20070901 |
| Arsenic trioxide-mediated growth inhibition in gallbladder carcinoma cells via down-regulation of Cyclin D1 transcription mediated by Sp1 transcription factor. | Biochemical and biophysical research communications 20070831 |
| Endothelial gap junctions are down-regulated by arsenic trioxide. | European journal of pharmacology 20070813 |
| Arsenic trioxide inhibits growth of As4.1 juxtaglomerular cells via cell cycle arrest and caspase-independent apoptosis. | American journal of physiology. Renal physiology 20070801 |
| Arsenic trioxide (As2O3) reduces the invasive and metastatic properties of cervical cancer cells in vitro and in vivo. | Gynecologic oncology 20070801 |
| PS-341 or a combination of arsenic trioxide and interferon-alpha inhibit growth and induce caspase-dependent apoptosis in KSHV/HHV-8-infected primary effusion lymphoma cells. | Leukemia 20070801 |
| Antimyeloma effects of arsenic trioxide are enhanced by melphalan, bortezomib and ascorbic acid. | British journal of haematology 20070801 |
| Cancer agents show first-line potential. | JAMA 20070725 |
| Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide. | Proceedings of the National Academy of Sciences of the United States of America 20070724 |
| Phototactic behavior in Daphnia magna Straus as an indicator of toxicants in the aquatic environment. | Ecotoxicology and environmental safety 20070701 |
| In-vitro cytotoxic and genotoxic effects of arsenic trioxide on human leukemia (HL-60) cells using the MTT and alkaline single cell gel electrophoresis (Comet) assays. | Molecular and cellular biochemistry 20070701 |
| Arsenic trioxide and proteasome inhibitor bortezomib synergistically induce apoptosis in leukemic cells: the role of protein kinase Cdelta. | Leukemia 20070701 |
| [HL-60 cell apoptosis induced by bortezomib alone or in combination with arsenic trioxide in vitro]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20070701 |
| [The effect of arsenic trioxide (As2O3) combined with BSO on K562/ADM cell and its mechanisms]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20070701 |
| Treatment of acute promyelocytic leukaemia with all-trans retinoic acid and arsenic trioxide: a paradigm of synergistic molecular targeting therapy. | Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20070629 |
| Protection against arsenic trioxide-induced autophagic cell death in U118 human glioma cells by use of lipoic acid. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20070601 |
| JWA as a functional molecule to regulate cancer cells migration via MAPK cascades and F-actin cytoskeleton. | Cellular signalling 20070601 |
| Arsenic trioxide induces accumulation of cytotoxic levels of ceramide in acute promyelocytic leukemia and adult T-cell leukemia/lymphoma cells through de novo ceramide synthesis and inhibition of glucosylceramide synthase activity. | Haematologica 20070601 |
| Enhanced Bcr-Abl-specific antileukemic activity of arsenic trioxide (Trisenox) through glutathione-depletion in imatinib-resistant cells. | Haematologica 20070601 |
| Targeting transcription factors in acute leukemia in children. | Current drug targets 20070601 |
| Arsenic trioxide (As2O3) induced calcium signals and cytotoxicity in two human cell lines: SY-5Y neuroblastoma and 293 embryonic kidney (HEK). | Toxicology and applied pharmacology 20070501 |
| Comparison of diarsenic oxide and tetraarsenic oxide on anticancer effects: relation to the apoptosis molecular pathway. | International journal of oncology 20070501 |
| ASK1 is activated by arsenic trioxide in leukemic cells through accumulation of reactive oxygen species and may play a negative role in induction of apoptosis. | Biochemical and biophysical research communications 20070420 |
| Regulating effects of arsenic trioxide on cell death pathways and inflammatory reactions of pancreatic acinar cells in rats. | Chinese medical journal 20070420 |
| Prolonged molecular remission in a newly diagnosed acute promyelocytic leukaemia with a severe cardiomyopathy using low-dose gemtuzumab ozogamicin and all-trans retinoic acid. | Annals of hematology 20070401 |
| Induction of apoptosis and inhibition of telomerase activity by arsenic trioxide (As2O3) in endometrial carcinoma cells. | Gynecologic oncology 20070401 |
| Combination therapy with arsenic trioxide, all-trans retinoic acid, and gemtuzumab ozogamicin in recurrent acute promyelocytic leukemia. | Cancer 20070401 |
| Arsenic trioxide induces p53-dependent apoptotic signals in myeloma cells with SiRNA-silenced p53: MAP kinase pathway is preferentially activated in cells expressing inactivated p53. | International journal of oncology 20070401 |
| Therapeutic effect of arsenic trioxide (As2O3) on cervical cancer in vitro and in vivo through apoptosis induction. | Cancer biology & therapy 20070401 |
| Successful treatment of potentially fatal heavy metal poisonings. | The Journal of emergency medicine 20070401 |
| Synergism between arsenic trioxide and heat shock protein 90 inhibitors on signal transducer and activator of transcription protein 3 activity--pharmacodynamic drug-drug interaction modeling. | Clinical cancer research : an official journal of the American Association for Cancer Research 20070401 |
| [Effects of arsenic trioxide or retinoic acid on mRNA and protein expression of tissue factor and thrombomodulin and procoagulant activity in NB4 cells]. | Zhongguo shi yan xue ye xue za zhi 20070401 |
| [Effect of Rhizoma Curcumae and arsenite trioxide on proliferation and signal transduction molecule of lens epithelial cell]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070401 |
| Arsenic metabolism in multiple myeloma and astrocytoma cells. | Biological trace element research 20070401 |
| A phase I/II study of arsenic trioxide/bortezomib/ascorbic acid combination therapy for the treatment of relapsed or refractory multiple myeloma. | Clinical cancer research : an official journal of the American Association for Cancer Research 20070315 |
| Arsenic trioxide induces not only apoptosis but also autophagic cell death in leukemia cell lines via up-regulation of Beclin-1. | Leukemia research 20070301 |
| Treatment of relapsed or refractory acute promyelocytic leukemia. | Best practice & research. Clinical haematology 20070301 |
| Arsenic but not all-trans retinoic acid overcomes the aberrant stem cell capacity of PML/RARalpha-positive leukemic stem cells. | Haematologica 20070301 |
| [Effects of controlled-release arsenic-trioxide-eluting stents on in-stent neointimal hyperplasia in coronary artery: experiment with dog model]. | Zhonghua yi xue za zhi 20070227 |
| Emodin and DHA potently increase arsenic trioxide interferon-alpha-induced cell death of HTLV-I-transformed cells by generation of reactive oxygen species and inhibition of Akt and AP-1. | Blood 20070215 |
| Effects of arsenic trioxide on the cellular proliferation, apoptosis and differentiation of human neuroblastoma cells. | Cancer letters 20070208 |
| Induction of oxidative stress by arsenic in Clarias batrachus: involvement of peroxisomes. | Ecotoxicology and environmental safety 20070201 |
| 8-Oxoguanine DNA glycosylase and MutY homolog are involved in the incision of arsenite-induced DNA adducts. | Toxicological sciences : an official journal of the Society of Toxicology 20070201 |
| Arsenic trioxide induces apoptosis via the mitochondrial pathway by upregulating the expression of Bax and Bim in human B cells. | International journal of oncology 20070201 |
| An approach to elucidate potential mechanism of renal toxicity of arsenic trioxide. | Experimental hematology 20070201 |
| [n-MSP detection of p16 gene demethylation and transcription in human multiple myeloma U266 cell line induced by arsenic trioxide]. | Zhongguo shi yan xue ye xue za zhi 20070201 |
| Relationship of expression of aquaglyceroporin 9 with arsenic uptake and sensitivity in leukemia cells. | Blood 20070115 |
| Cytotoxic effects of various stressors on PC12 cells: involvement of oxidative stress and effect of antioxidants. | Neurotoxicology 20070101 |
| Arsenic trioxide and acute promyelocytic leukemia: clinical and biological. | Current topics in microbiology and immunology 20070101 |
| The design of selective and non-selective combination therapy for acute promyelocytic leukemia. | Current topics in microbiology and immunology 20070101 |
| Combination treatment with arsenic trioxide and phytosphingosine enhances apoptotic cell death in arsenic trioxide-resistant cancer cells. | Molecular cancer therapeutics 20070101 |
| Programmed cell death-4 tumor suppressor protein contributes to retinoic acid-induced terminal granulocytic differentiation of human myeloid leukemia cells. | Molecular cancer research : MCR 20070101 |
| [Methylation of P15INK4B gene in patients with myelodysplastic syndromes and demethylating effects of drugs]. | Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20070101 |
| Acute promyelocytic leukemia: new issues on pathogenesis and treatment response. | The international journal of biochemistry & cell biology 20070101 |
| Arsenic trioxide/ascorbic acid therapy in patients with refractory metastatic colorectal carcinoma: a clinical experience. | Acta oncologica (Stockholm, Sweden) 20070101 |
| Effect of n-propylthiouracil or thyroxine on arsenic trioxide toxicity in the liver of rat. | Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 20070101 |
| [Two different clinical cases of acute arsenic trioxide intoxication]. | Przeglad lekarski 20070101 |
| Effect of arsenic trioxide on uveal melanoma cell proliferation in vitro. | Ophthalmic research 20070101 |
| Arsenic trioxide: A promising novel therapeutic agent for lymphoproliferative and autoimmune syndromes in MRL/lpr mice. | Blood 20061215 |
| Mammalian glucose permease GLUT1 facilitates transport of arsenic trioxide and methylarsonous acid. | Biochemical and biophysical research communications 20061215 |
| Pharmacologic inhibitors of extracellular signal-regulated kinase (ERKs) and c-Jun NH(2)-terminal kinase (JNK) decrease glutathione content and sensitize human promonocytic leukemia cells to arsenic trioxide-induced apoptosis. | Journal of cellular physiology 20061201 |
| Phase II multicenter study of arsenic trioxide, ascorbic acid and dexamethasone in patients with relapsed or refractory multiple myeloma. | Haematologica 20061201 |
| Buthionine sulfoximine enhancement of arsenic trioxide-induced apoptosis in leukemia and lymphoma cells is mediated via activation of c-Jun NH2-terminal kinase and up-regulation of death receptors. | Cancer research 20061201 |
| Effect of ginseng saponin, arsenic trioxide, beta-elemene combined with CTX on telomere-telomerase system in K562 cell line. | Zhongguo shi yan xue ye xue za zhi 20061201 |
| Relationship between cytokines and leukocytosis in patients with APL induced by all-trans retinoic acid or arsenic trioxide. | Cellular & molecular immunology 20061201 |
| Arsenic trioxide represses NF-kappaB activation and increases apoptosis in ATRA-treated APL cells. | Annals of the New York Academy of Sciences 20061201 |
| Synergistic induction of apoptosis by sulindac and arsenic trioxide in human lung cancer A549 cells via reactive oxygen species-dependent down-regulation of survivin. | Biochemical pharmacology 20061115 |
| ZNF198, a zinc finger protein rearranged in myeloproliferative disease, localizes to the PML nuclear bodies and interacts with SUMO-1 and PML. | Experimental cell research 20061115 |
| Arsenic trioxide affects signal transducer and activator of transcription proteins through alteration of protein tyrosine kinase phosphorylation. | Clinical cancer research : an official journal of the American Association for Cancer Research 20061115 |
| Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors. | Molecular cell 20061103 |
| Arrhythmogenic effects of arsenic trioxide in patients with acute promyelocytic leukemia and an electrophysiological study in isolated guinea pig papillary muscles. | Circulation journal : official journal of the Japanese Circulation Society 20061101 |
| Increased oxidative DNA products in patients with acute promyelocytic leukemia during arsenic therapy. | Haematologica 20061101 |
| Optimizing treatment for elderly patients with acute promyelocytic leukemia: is it time to replace chemotherapy with all-trans retinoic acid and arsenic trioxide? | Leukemia & lymphoma 20061101 |
| Activation of mammalian target of rapamycin and the p70 S6 kinase by arsenic trioxide in BCR-ABL-expressing cells. | Molecular cancer therapeutics 20061101 |
| Lipid encapsulation of arsenic trioxide attenuates cytotoxicity and allows for controlled anticancer drug release. | Journal of the American Chemical Society 20061018 |
| Arsenic-induced histopathology and synthesis of stress proteins in liver and kidney of Channa punctatus. | Ecotoxicology and environmental safety 20061001 |
| Arsenic trioxide (As(2)O(3)) inhibits peritoneal invasion of ovarian carcinoma cells in vitro and in vivo. | Gynecologic oncology 20061001 |
| Clinically tolerable concentrations of arsenic trioxide induce p53-independent cell death and repress NF-kappa B activation in Ewing sarcoma cells. | International journal of cancer 20061001 |
| Role of GSTP1-1 in mediating the effect of As2O3 in the Acute Promyelocytic Leukemia cell line NB4. | Annals of hematology 20061001 |
| Real-time PCR analysis of PML-RAR alpha in newly diagnosed acute promyelocytic leukaemia patients treated with arsenic trioxide as a front-line therapy. | Annals of oncology : official journal of the European Society for Medical Oncology 20061001 |
| The effect of intracellular ascorbate on the susceptibility of HL60 and Jurkat cells to chemotherapy agents. | Apoptosis : an international journal on programmed cell death 20061001 |
| Efficacy and safety of melphalan, arsenic trioxide and ascorbic acid combination therapy in patients with relapsed or refractory multiple myeloma: a prospective, multicentre, phase II, single-arm study. | British journal of haematology 20061001 |
| Synergistic effect of arsenic trioxide and flt3 inhibition on cells with flt3 internal tandem duplication. | International journal of hematology 20061001 |
| [Study of effects of HBV X gene and As2O3 on expression and activity of p53 in HepG2 cells with shRNA]. | Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20061001 |
| [Mechanisms of arsenic trioxide induced tumor cell apoptosis in myelodysplastic syndrome mice model in vivo]. | Zhonghua er ke za zhi = Chinese journal of pediatrics 20061001 |
| ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis. | The Journal of biological chemistry 20060929 |
| Arsenic trioxide induces gallbladder carcinoma cell apoptosis via downregulation of Bcl-2. | Biochemical and biophysical research communications 20060929 |
| Inhibitory effect of arsenic trioxide on angiogenesis and expression of vascular endothelial growth factor in gastric cancer. | World journal of gastroenterology 20060928 |
| Anion exchanger 2 mediates the action of arsenic trioxide. | British journal of haematology 20060901 |
| Leukocytosis and retinoic acid syndrome in patients with acute promyelocytic leukemia treated with arsenic trioxide. | Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 20060901 |
| Role of oxidative stress in the apoptosis of hepatocellular carcinoma induced by combination of arsenic trioxide and ascorbic acid. | Acta pharmacologica Sinica 20060801 |
| [Inhibited proliferation of B-lymphoma Raji cells and down-regulated expression of VEGF by arsenic trioxide]. | Zhongguo shi yan xue ye xue za zhi 20060801 |
| Down-regulation of wt1 expression in leukemia cell lines as part of apoptotic effect in arsenic treatment using two compounds. | Leukemia & lymphoma 20060801 |
| [Therapeutic strategies for patients with relapsed acute promyelocytic leukemia]. | [Rinsho ketsueki] The Japanese journal of clinical hematology 20060801 |
| Superiority of an arsenic trioxide-based regimen over a historic control combining all-trans retinoic acid plus intensive chemotherapy in the treatment of relapsed acute promyelocytic leukemia. | Haematologica 20060701 |
| Role of the p38 mitogen-activated protein kinase pathway in the generation of arsenic trioxide-dependent cellular responses. | Cancer research 20060701 |
| Imatinib activity in vitro in tumor cells from patients with chronic myeloid leukemia in chronic phase and blast crisis. | Anti-cancer drugs 20060701 |
| Arsenic trioxide-responsive leukemia cutis in a patient with acute promyelocytic leukemia after ATRA treatment. | Leukemia & lymphoma 20060701 |
| [Preliminary report of combination chemotherapy including Arsenic trioxide for stage III osteosarcoma and Ewing sarcoma]. | Zhonghua wai ke za zhi [Chinese journal of surgery] 20060615 |
| Mitogen-activated protein kinases mediate arsenic-induced down-regulation of survivin in human lung adenocarcinoma cells. | Archives of toxicology 20060601 |
| MEK1 inhibition sensitizes primary acute myelogenous leukemia to arsenic trioxide-induced apoptosis. | Blood 20060601 |
| Upregulation of Bfl-1/A1 in leukemia cells undergoing differentiation by all-trans retinoic acid treatment attenuates chemotherapeutic agent-induced apoptosis. | Leukemia 20060601 |
| Phase II multicenter study of arsenic trioxide in patients with myelodysplastic syndromes. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060601 |
| Combination treatment with arsenic trioxide and sulindac augments their apoptotic potential in lung cancer cells through activation of caspase cascade and mitochondrial dysfunction. | International journal of oncology 20060601 |
| Sustained activation of c-jun-N-terminal kinase plays a critical role in arsenic trioxide-induced cell apoptosis in multiple myeloma cell lines. | Cancer science 20060601 |
| Dose- and time-dependent response of human leukemia (HL-60) cells to arsenic trioxide treatment. | International journal of environmental research and public health 20060601 |
| Use of all-trans retinoic acid plus arsenic trioxide as an alternative to chemotherapy in untreated acute promyelocytic leukemia. | Blood 20060501 |
| PLC-beta2 monitors the drug-induced release of differentiation blockade in tumoral myeloid precursors. | Journal of cellular biochemistry 20060501 |
| Hepatotoxicity profile of single agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia, its impact on clinical outcome and the effect of genetic polymorphisms on the incidence of hepatotoxicity. | Leukemia 20060501 |
| Late first relapses in APL treated with all-trans-retinoic acid- and anthracycline- based chemotherapy: the European APL group experience (APL 91 and APL 93 trials). | Leukemia 20060501 |
| Arsenic trioxide reduces the invasive and metastatic properties of nasopharyngeal carcinoma cells in vitro. | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20060501 |
| Two cases of acute promyelocytic leukemia complicated by torsade de pointes during arsenic trioxide therapy. | International journal of hematology 20060501 |
| Recurrent extramedullary relapse of acute promyelocytic leukemia after allogeneic stem cell transplantation: successful treatment by arsenic trioxide in combination with local radiotherapy. | International journal of hematology 20060501 |
| [Further improving the standard of treatment for chronic myeloid leukemia]. | Zhonghua nei ke za zhi 20060501 |
| [The diagnosis and treatment of polycythemia rubra vera manifesting as acute cerebral stroke]. | Zhonghua nei ke za zhi 20060501 |
| Arsenic trioxide synergizes with B7H3-mediated immunotherapy to eradicate hepatocellular carcinomas. | International journal of cancer 20060401 |
| Targeting Hsp90 by 17-AAG in leukemia cells: mechanisms for synergistic and antagonistic drug combinations with arsenic trioxide and Ara-C. | Leukemia 20060401 |
| Cardiotoxic effects of arsenic trioxide/imatinib mesilate combination in rats. | The Journal of pharmacy and pharmacology 20060401 |
| Choline-modulated arsenic trioxide-induced prolongation of cardiac repolarization in Guinea pig. | Basic & clinical pharmacology & toxicology 20060401 |
| [Alteration of expression of survivin in HL-60 cells treated with chemotherapeutic drugs]. | Zhongguo shi yan xue ye xue za zhi 20060401 |
| [The plasma cell myeloma--molecular pathogenesis and target therapies]. | Therapeutische Umschau. Revue therapeutique 20060401 |
| Influence of thyroxine and n-propylthiouracil on nephro-toxicity of inorganic arsenic in rat. | Toxicology and industrial health 20060401 |
| Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs. | The Journal of pharmacology and experimental therapeutics 20060301 |
| Increased cellular glutathione and protection by bone marrow stromal cells account for the resistance of non-acute promylocytic leukemia acute myeloid leukemia cells to arsenic trioxide in vivo. | Leukemia & lymphoma 20060301 |
| [Changes of gene expression profile of multiple myeloma cell line RPMI 8226 treated by arsenic trioxide]. | Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20060301 |
| Arsenic trioxide inhibits DNA methyltransferase and restores methylation-silenced genes in human liver cancer cells. | Human pathology 20060301 |
| [Experimental study of the anti-tumor effect of arsenic trioxide or thalidomide alone and combination of both for treatment of myelodysplastic syndrome model]. | Zhonghua er ke za zhi = Chinese journal of pediatrics 20060301 |
| Arsenic trioxide as a treatment for myelodysplastic syndrome. | Current hematologic malignancy reports 20060301 |
| Coordination of intrinsic, extrinsic, and endoplasmic reticulum-mediated apoptosis by imatinib mesylate combined with arsenic trioxide in chronic myeloid leukemia. | Blood 20060215 |
| TRAIL sensitisation by arsenic trioxide is caspase-8 dependent and involves modulation of death receptor components and Akt. | British journal of cancer 20060213 |
| As2O3-induced c-Src/EGFR/ERK signaling is via Sp1 binding sites to stimulate p21WAF1/CIP1 expression in human epidermoid carcinoma A431 cells. | Cellular signalling 20060201 |
| Arsenic trioxide (AT) is a novel human neutrophil pro-apoptotic agent: effects of catalase on AT-induced apoptosis, degradation of cytoskeletal proteins and de novo protein synthesis. | British journal of haematology 20060201 |
| Oxidative stress and apoptosis: a new treatment paradigm in cancer. | Frontiers in bioscience : a journal and virtual library 20060101 |
| Arsenic trioxide induces apoptosis of human monocytes during macrophagic differentiation through nuclear factor-kappaB-related survival pathway down-regulation. | The Journal of pharmacology and experimental therapeutics 20060101 |
| Treatment of acute promyelocytic leukemia with arsenic trioxide without ATRA and/or chemotherapy. | Annals of oncology : official journal of the European Society for Medical Oncology 20060101 |
| Opposite effect of ERK1/2 and JNK on p53-independent p21WAF1/CIP1 activation involved in the arsenic trioxide-induced human epidermoid carcinoma A431 cellular cytotoxicity. | Journal of biomedical science 20060101 |
| In vitro dual effect of arsenic trioxide on hemopoiesis: inhibition of erythropoiesis and stimulation of megakaryocytic maturation. | Blood cells, molecules & diseases 20060101 |
| Novel agents aiming at specific molecular targets increase chemosensitivity and overcome chemoresistance in hematopoietic malignancies. | Current pharmaceutical design 20060101 |
| Treatment of acute promyelocytic leukemia with gemtuzumab ozogamicin. | Clinical advances in hematology & oncology : H&O 20060101 |
| Arsenic trioxide-loaded, microemulsion-enhanced cytotoxicity on MDAH 2774 ovarian carcinoma cell line. | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20060101 |
| Mechanism of arsenic trioxide inhibiting angiogenesis in multiple myeloma. | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20060101 |
| Efficacy and safety results with the combination therapy of arsenic trioxide, dexamethasone, and ascorbic acid in multiple myeloma patients: a phase 2 trial. | Medical oncology (Northwood, London, England) 20060101 |
| The emerging role of arsenic trioxide as an immunomodulatory agent in the management of multiple myeloma. | Acta haematologica 20060101 |
| Arsenic and cigarette smoke synergistically increase DNA oxidation in the lung. | Toxicologic pathology 20060101 |
| Arsenic trioxide exposure to ovarian carcinoma cells leads to decreased level of topoisomerase II and cytotoxicity. | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20060101 |
| Arsenic trioxide, a potent inhibitor of NF-kappaB, abrogates allergen-induced airway hyperresponsiveness and inflammation. | Respiratory research 20060101 |
| NF-kappaB and FLIP in arsenic trioxide (ATO)-induced apoptosis in myelodysplastic syndromes (MDSs). | Blood 20051201 |
| Hypoxia-simulating agents selectively stimulate arsenic trioxide-induced growth arrest and cell differentiation in acute promyelocytic leukemic cells. | Haematologica 20051201 |
| Hypoxia-simulating agents and selective stimulation of arsenic trioxide-induced growth arrest and cell differentiation in acute promyelocytic leukemic cells. | Haematologica 20051201 |
| Inhibition of mitogen-activated protein kinase kinase enhances apoptosis induced by arsenic trioxide in human breast cancer MCF-7 cells. | Clinical and experimental pharmacology & physiology 20051201 |
| [New strategy for the treatment of multiple myeloma]. | [Rinsho ketsueki] The Japanese journal of clinical hematology 20051201 |
| New treatments for multiple myeloma. | Oncology (Williston Park, N.Y.) 20051201 |
| Management of patients with higher risk myelodysplastic syndromes. | Critical reviews in oncology/hematology 20051101 |
| Arsenic trioxide overcomes apoptosis inhibition in K562/ADM cells by regulating vital components in apoptotic pathway. | Pharmacological research 20051101 |
| [Oral administration of arsenic trioxide induced molecular remission in relapsed acute promyelocytic leukemia]. | [Rinsho ketsueki] The Japanese journal of clinical hematology 20051101 |
| [Role of arsenolite on 8-isoprostane of asthmatic mice plasm]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20051101 |
| Arsenic trioxide induces regulated, death receptor-independent cell death through a Bcl-2-controlled pathway. | Oncogene 20051027 |
| Arsenic trioxide induces Hsp70 expression via reactive oxygen species and JNK pathway in MDA231 cells. | Life sciences 20051014 |
| Anti-hepatoma effect of arsenic trioxide on experimental liver cancer induced by 2-acetamidofluorene in rats. | World journal of gastroenterology 20051014 |
| Comparison of the cytotoxicity of the MEIC reference chemicals measured in protein free and in complete culture medium. | Toxicology in vitro : an international journal published in association with BIBRA 20051001 |
| Retinoid/arsenic combination therapy of promyelocytic leukemia: induction of telomerase-dependent cell death. | Leukemia 20051001 |
| Arsenic trioxide inhibits nuclear receptor function via SEK1/JNK-mediated RXRalpha phosphorylation. | The Journal of clinical investigation 20051001 |
| Arsenic trioxide therapy in relapsed or refractory Japanese patients with acute promyelocytic leukemia: updated outcomes of the phase II study and postremission therapies. | International journal of hematology 20051001 |
| [In vitro study on inhibition of human choroidal melanoma OCM-1 cell line by arsenic trioxide]. | [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20051001 |
| [Effects of arsenic trioxideon the cell apoptosis and hTERT mRNA of human tongue cancer cells]. | Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology 20051001 |
| Synergistic effect of all-trans-retinoic acid and arsenic trioxide on growth inhibition and apoptosis in human hepatoma, breast cancer, and lung cancer cells in vitro. | World journal of gastroenterology 20050928 |
| Phosphoinositide 3-kinase/Akt inhibition increases arsenic trioxide-induced apoptosis of acute promyelocytic and T-cell leukaemias. | British journal of haematology 20050901 |
| Oxidative DNA damage in relation to neurotoxicity in the brain of mice exposed to arsenic at environmentally relevant levels. | Journal of occupational health 20050901 |
| Overview of drug therapy for multiple myeloma. | Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20050901 |
| Green tea component, catechin, induces apoptosis of human malignant B cells via production of reactive oxygen species. | Clinical cancer research : an official journal of the American Association for Cancer Research 20050815 |
| Proapoptotic regimes for HTLV-I-transformed cells: targeting Tax and the NF-kappaB pathway. | Cell death and differentiation 20050801 |
| Efficacy of gemtuzumab ozogamicin on ATRA- and arsenic-resistant acute promyelocytic leukemia (APL) cells. | Leukemia 20050801 |
| Arsenic trioxide (As2O3) inhibits invasion of HT1080 human fibrosarcoma cells: role of nuclear factor-kappaB and reactive oxygen species. | Journal of cellular biochemistry 20050801 |
| Arsenic trioxide mediates intrinsic and extrinsic pathways of apoptosis and cell cycle arrest in acute megakaryocytic leukemia. | International journal of oncology 20050801 |
| Perspectives for combination therapy to overcome drug-resistant multiple myeloma. | Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20050801 |
| [Anti-hepatoma effect of arsenic trioxide on rat liver cancers induced by 2-acetamidofluorene]. | Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20050801 |
| [Study on the mechanisms of telomerase regulations during apoptosis of the human MDS-RAEB cell line MUTZ-1 cells induced by arsenic trioxide]. | Zhongguo shi yan xue ye xue za zhi 20050801 |
| Delayed recovery of normal hematopoiesis in arsenic trioxide treatment of acute promyelocytic leukemia: a comparison to all-trans retinoic acid treatment. | Internal medicine (Tokyo, Japan) 20050801 |
| Multidrug-resistant neuroblastoma cells are responsive to arsenic trioxide at both normoxia and hypoxia. | Molecular cancer therapeutics 20050701 |
| Gene expression alteration during redox-dependent enhancement of arsenic cytotoxicity by emodin in HeLa cells. | Cell research 20050701 |
| Absorption and metabolism of paracetamol in rats drinking high concentration of arsenic. | Mymensingh medical journal : MMJ 20050701 |
| Arsenic trioxide-induced hela cell death is partially prevented by K+ channel blockers. | Yao xue xue bao = Acta pharmaceutica Sinica 20050701 |
| Hematological and molecular remission with combination chemotherapy in a patient with PLZF-RARalpha acute promyelocytic leukemia (APML). | Annals of hematology 20050601 |
| Elimination of the differential chemoresistance between the murine B-cell lymphoma LY-ar and LY-as cell lines after arsenic (As2O3) exposure via the overexpression of gsto1 (p28). | Cancer chemotherapy and pharmacology 20050601 |
| [Hypermethylation of CpG island of p16 gene and arsenic trioxide induced p16 gene demethylation in multiple myeloma]. | Zhonghua nei ke za zhi 20050601 |
| Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. | Proceedings of the National Academy of Sciences of the United States of America 20050524 |
| Up-regulation of telomere-binding TRF1, TRF2 related to reactive oxygen species induced by As(2)O(3) in MGC-803 cells. | European journal of pharmacology 20050523 |
| Pharmacologic inhibitors of PI3K/Akt potentiate the apoptotic action of the antileukemic drug arsenic trioxide via glutathione depletion and increased peroxide accumulation in myeloid leukemia cells. | Blood 20050515 |
| [Primary research on arsenic trioxide inhibiting human breast cancer cells growth and its mechanisms]. | Zhonghua yi xue za zhi 20050511 |
| Arsenic trioxide (As(2)O(3)) induces apoptosis through activation of Bax in hematopoietic cells. | Oncogene 20050505 |
| Diarsenic and tetraarsenic oxide inhibit cell cycle progression and bFGF- and VEGF-induced proliferation of human endothelial cells. | Journal of cellular biochemistry 20050501 |
| Triterpenoid CDDO-Im downregulates PML/RARalpha expression in acute promyelocytic leukemia cells. | Cell death and differentiation 20050501 |
| Chronic myelogenous leukemia in accelerated phase. | Archives of pathology & laboratory medicine 20050501 |
| The role of Akt on arsenic trioxide suppression of 3T3-L1 preadipocyte differentiation. | Cell research 20050501 |
| [The association of HeLa cell apoptosis induced by arsenic trioxide with the down-regulation of HPV18 E6 oncogene and inhibition of telomerase activity]. | Zhonghua zhong liu za zhi [Chinese journal of oncology] 20050501 |
| As2O3 enhances the anion transport activity of band 3 and the action is related with the C-terminal 16 residues of the protein. | Journal of drug targeting 20050501 |
| Serum acetyl cholinesterase as a biomarker of arsenic induced neurotoxicity in sprague-dawley rats. | International journal of environmental research and public health 20050501 |
| [Effect of 2-methoxyestradiol on proliferation and apoptosis of myeloma cell lines]. | Zhongguo shi yan xue ye xue za zhi 20050401 |
| Targeted therapy in multiple myeloma. | Cancer control : journal of the Moffitt Cancer Center 20050401 |
| [Investigation of the effect of 2-methoxyestradiol and arsenic trioxide on the apoptosis-associated gene expression profile of myeloma cells]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20050401 |
| [Detection of gene expression alteration of myeloma cells treated with arsenic trioxide]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20050401 |
| [Effects of dexamethasone on arsenic trioxide induced apoptosis, NF-kappaB activation and gene expression in lymphoma cell line]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20050401 |
| Retinoic acid and arsenic trioxide cooperate for apoptosis through phosphorylated RXR alpha. | Oncogene 20050331 |
| 19-Nor-1,25(OH)2D2 (a novel, noncalcemic vitamin D analogue), combined with arsenic trioxide, has potent antitumor activity against myeloid leukemia. | Cancer research 20050315 |
| PRAM-1 potentiates arsenic trioxide-induced JNK activation. | The Journal of biological chemistry 20050311 |
| Arsenic trioxide triggers a regulated form of caspase-independent necrotic cell death via the mitochondrial death pathway. | Oncogene 20050310 |
| Arsenic trioxide represses constitutive activation of NF-kappaB and COX-2 expression in human acute myeloid leukemia, HL-60. | Journal of cellular biochemistry 20050301 |
| Simultaneous and ultrarapid determination of reactive oxygen species and reduced glutathione in apoptotic leukemia cells by microchip electrophoresis. | Electrophoresis 20050301 |
| Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo. | British journal of haematology 20050301 |
| Innovations in antineoplastic therapy. | The Nursing clinics of North America 20050301 |
| Requirement for myeloid growth factors in the differentiation of acute promyelocytic leukaemia. | British journal of haematology 20050301 |
| Use of arsenic trioxide in haematological malignancies: insight into the clinical development of a novel agent. | Current medical research and opinion 20050301 |
| Acute lung injury induced by arsenic trioxide in a patient with refractory myelodysplastic syndrome. | Journal of critical care 20050301 |
| [Arsenic treatment for leukemia: new model of human cancer target treatment]. | Zhonghua yi xue za zhi 20050223 |
| Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3. | Oncogene 20050203 |
| Phosphoinositide 3-kinase/Akt involvement in arsenic trioxide resistance of human leukemia cells. | Journal of cellular physiology 20050201 |
| Biological effects of Atra and Arsenic Trioxide on short term cultures of non-M3 leukemic blasts. | Leukemia & lymphoma 20050201 |
| Significance of intracellular arsenic trioxide for therapeutic response in acute promyelocytic leukemia. | American journal of hematology 20050201 |
| Preparation of arsenic trioxide-loaded albuminutes immuno-nanospheres and its specific killing effect on bladder cancer cell in vitro. | Chinese medical journal 20050105 |
| Efficacy of melphalan, arsenic trioxide, and ascorbic acid combination therapy (MAC) in relapsed and refractory multiple myeloma. | Leukemia 20050101 |
| Effects of 1, 6-Bis[4-(4-amino-3-hydroxyphenoxy)phenyl]diamantane (DPD), a reactive oxygen species and apoptosis inducing agent, on human leukemia cells in vitro and in vivo. | Toxicology and applied pharmacology 20050101 |
| Acute promyelocytic leukemia: recent advances in therapy and molecular basis of response to arsenic therapies. | Current opinion in hematology 20050101 |
| Arsenic trioxide as a treatment for myelodysplastic syndrome. | Current hematology reports 20050101 |
| [The effect and mechanism of arsenic trioxide on hepatocellular carcinoma]. | Zhonghua wai ke za zhi [Chinese journal of surgery] 20050101 |
| Arsenic trioxide circumvents multidrug resistance based on different mechanisms in human leukemia cell lines. | Anticancer research 20050101 |
| Morphological and biochemical changes induced by arsenic trioxide in neuroblastoma cell lines. | Pediatric hematology and oncology 20050101 |
| Preparation of arsenic trioxide albumin microspheres and its release characteristics in vitro. | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20050101 |
| Arsonoliposomes: effect of lipid composition on their stability and morphology. | Journal of liposome research 20050101 |
| Anthraquinones sensitize tumor cells to arsenic cytotoxicity in vitro and in vivo via reactive oxygen species-mediated dual regulation of apoptosis. | Free radical biology & medicine 20041215 |
| Depolarisation of the plasma membrane in the arsenic trioxide (As2O3)-and anti-CD95-induced apoptosis in myeloid cells. | FEBS letters 20041203 |
| Sodium selenite induces apoptosis in acute promyelocytic leukemia-derived NB4 cells by a caspase-3-dependent mechanism and a redox pathway different from that of arsenic trioxide. | Annals of hematology 20041201 |
| Targeting multiple myeloma cells and their bone marrow microenvironment. | Annals of the New York Academy of Sciences 20041201 |
| Repeated arsenic trioxide intravenous infusion causes focal bone marrow necrosis in two acute promyelocytic leukemia patients. | Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 20041201 |
| Zinc protects against arsenic-induced apoptosis in a neuronal cell line, measured by DEVD-caspase activity. | Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20041201 |
| Effect of arsenic trioxide (ATO) on human lung carcinoma PG cell line: ATO induced apoptosis of PG cells and decreased expression of Bcl-2, Pgp. | Journal of experimental therapeutics & oncology 20041201 |
| Arsenic trioxide sensitizes CD95/Fas-induced apoptosis through ROS-mediated upregulation of CD95/Fas by NF-kappaB activation. | International journal of cancer 20041120 |
| Enhancement of arsenic trioxide-mediated apoptosis using docosahexaenoic acid in arsenic trioxide-resistant solid tumor cells. | International journal of cancer 20041120 |
| L-ascorbic acid represses constitutive activation of NF-kappaB and COX-2 expression in human acute myeloid leukemia, HL-60. | Journal of cellular biochemistry 20041001 |
| Molecular remission with arsenic trioxide in patients with newly diagnosed acute promyelocytic leukemia. | Haematologica 20041001 |
| [Study on effect of arsenic trioxide on adhesion and invasion of human hepatocarcinoma cells in vitro]. | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20041001 |
| [Effect of arsenic trioxide on drug transporting molecules in acute promyelocytic leukemia cell line]. | Zhonghua zhong liu za zhi [Chinese journal of oncology] 20041001 |
| [Effects of protein tyrosine kinase, protein tyrosine phosphatase and protein kinase C on the apoptosis of arsenic trioxide treated NB4 cells and human cortex neurons]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20041001 |
| Drug uptake and pharmacological modulation of drug sensitivity in leukemia by AQP9. | Biochemical and biophysical research communications 20040924 |
| Extramedullary relapse in a patient with acute promyelocytic leukemia: successful treatment with arsenic trioxide, all-trans retinoic acid and gemtuzumab ozogamicin therapies. | Leukemia research 20040901 |
| Inhibition of cell proliferation and the action mechanisms of arsenic trioxide (As2O3) on human breast cancer cells. | Journal of cellular biochemistry 20040901 |
| A prospective, open-label safety and efficacy study of combination treatment with melphalan, arsenic trioxide, and ascorbic acid in patients with relapsed or refractory multiple myeloma. | Clinical lymphoma 20040901 |
| [Relationship between drug resistance and the expression of NF-kappaB induced in leukemic cells]. | Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20040901 |
| Characterization of molecular events in a series of bladder urothelial carcinoma cell lines with progressive resistance to arsenic trioxide. | Anti-cancer drugs 20040901 |
| [Synergistic inhibitory effect of STI571 in combination with arsenic trioxide on a multidrug-resistant leukemia cell line expressing bcr-abl]. | Zhonghua zhong liu za zhi [Chinese journal of oncology] 20040901 |
| Arsenic-induced genotoxic and cytotoxic effects in human keratinocytes, melanocytes and dendritic cells. | International journal of environmental research and public health 20040901 |
| Topoisomerase I-DNA complexes contribute to arsenic trioxide-induced apoptosis. | The Journal of biological chemistry 20040806 |
| Arsenic trioxide and thalidomide combination produces multi-lineage hematological responses in myelodysplastic syndromes patients, particularly in those with high pre-therapy EVI1 expression. | Leukemia research 20040801 |
| Evaluation of DNA damage in patients with arsenic poisoning: urinary 8-hydroxydeoxyguanine. | Toxicology and applied pharmacology 20040801 |
| Suppression of cell proliferation and regulation of estrogen receptor alpha signaling pathway by arsenic trioxide on human breast cancer MCF-7 cells. | The Journal of endocrinology 20040801 |
| Channelling the Emperor: what really killed Napoleon? | Journal of the Royal Society of Medicine 20040801 |
| Treatment with arsenic trioxide (ATO) and MEK1 inhibitor activates the p73-p53AIP1 apoptotic pathway in leukemia cells. | Blood 20040715 |
| A P53 target gene, PIG11, contributes to chemosensitivity of cells to arsenic trioxide. | FEBS letters 20040702 |
| Effective treatment of advanced solid tumors by the combination of arsenic trioxide and L-buthionine-sulfoximine. | Cell death and differentiation 20040701 |
| Acute promyelocytic leukemia cell line AP-1060 established as a cytokine-dependent culture from a patient clinically resistant to all-trans retinoic acid and arsenic trioxide. | Leukemia 20040701 |
| Mechanisms of arsenic-induced prolongation of cardiac repolarization. | Molecular pharmacology 20040701 |
| New drugs for treatment of multiple myeloma. | The Lancet. Oncology 20040701 |
| Effect of arsenic (AsIII) on glutathione-dependent enzymes in liver and kidney of the freshwater fish Channa punctatus. | Biological trace element research 20040701 |
| Carbohydrate metabolism in growing rice seedlings under arsenic toxicity. | Journal of plant physiology 20040701 |
| Arsenic trioxide poisoning: a description of two acute overdoses. | Human & experimental toxicology 20040701 |
| Enhancement of arsenic trioxide-induced apoptosis in renal cell carcinoma cells by L-buthionine sulfoximine. | International journal of oncology 20040601 |
| [Re-expression of p16 gene in myeloma cell line U266 by arsenic trioxide]. | Ai zheng = Aizheng = Chinese journal of cancer 20040601 |
| [Effects of arsenic trioxide, ginseng saponin and beta-elemene on telomere-telomerase system in K562 cell line]. | Zhongguo shi yan xue ye xue za zhi 20040601 |
| [Effect of arsenic trioxide on telomerase and telomerase reverse transcriptase in KM3 cell line]. | Zhongguo shi yan xue ye xue za zhi 20040601 |
| Investigational strategies in chronic myelogenous leukemia. | Hematology/oncology clinics of North America 20040601 |
| Combined effect of arsenic trioxide and sulindac sulfide in A549 human lung cancer cells in vitro. | Journal of experimental & clinical cancer research : CR 20040601 |
| An efficient therapeutic approach to patients with acute promyelocytic leukemia using a combination of arsenic trioxide with low-dose all-trans retinoic acid. | Hematological oncology 20040601 |
| Dual effects of glutathione-S-transferase pi on As2O3 action in prostate cancer cells: enhancement of growth inhibition and inhibition of apoptosis. | Oncogene 20040513 |
| JNK activation is a mediator of arsenic trioxide-induced apoptosis in acute promyelocytic leukemia cells. | Blood 20040501 |
| Synthesis of [75Se]5-ethoxycarbonyl-4-methyl-1,2,3-selenadiazole. | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20040501 |
| Arsenic trioxide-induced death of neuroblastoma cells involves activation of Bax and does not require p53. | Clinical cancer research : an official journal of the American Association for Cancer Research 20040501 |
| Phase 2 study of arsenic trioxide in patients with relapsed or refractory multiple myeloma. | British journal of haematology 20040501 |
| Hydrogen peroxide in the Burkitt's lymphoma cell line Raji provides protection against arsenic trioxide-induced apoptosis via the phosphoinositide-3 kinase signalling pathway. | British journal of haematology 20040501 |
| Arsenic trioxide uptake by hexose permeases in Saccharomyces cerevisiae. | The Journal of biological chemistry 20040423 |
| Arsenic trioxide uptake by human and rat aquaglyceroporins. | Biochemical and biophysical research communications 20040416 |
| All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia. | Proceedings of the National Academy of Sciences of the United States of America 20040413 |
| Resistance to oxidative stress in a freshwater fish Channa punctatus after exposure to inorganic arsenic. | Biological trace element research 20040401 |
| [Effects of combination therapy with all-trans retinoic acid and arsenic trioxide on acute promyelocytic leukemia]. | Ai zheng = Aizheng = Chinese journal of cancer 20040401 |
| Bone marrow necrosis in a patient with acute promyelocytic leukemia during re-induction therapy with arsenic trioxide. | European journal of haematology 20040401 |
| [Hydrogen peroxide inhibits arsenic trioxide-induced apoptosis of Burkitt lymphoma cells]. | Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20040401 |
| Phosphorylation of PML by mitogen-activated protein kinases plays a key role in arsenic trioxide-mediated apoptosis. | Cancer cell 20040401 |
| Multiple myeloma: the role of transplant and novel treatment strategies. | Seminars in oncology 20040401 |
| The PML-RARalpha fusion protein and targeted therapy for acute promyelocytic leukemia. | Leukemia & lymphoma 20040401 |
| Acute promyelocytic leukemia as a paradigm for targeted therapy. | Seminars in hematology 20040401 |
| [Clinical observation and following up of two administration methods of arsenic trioxide in treatment of acute promyelocytic leukemia]. | Zhonghua yi xue za zhi 20040302 |
| Arsenic trioxide and paclitaxel induce apoptosis by different mechanisms. | Cell cycle (Georgetown, Tex.) 20040301 |
| Arsenic trioxide is effective in the treatment of multiple myeloma in SCID mice. | European journal of haematology 20040301 |
| Radiofrequency ablation: Effect of pharmacologic modulation of hepatic and renal blood flow on coagulation diameter in a VX2 tumor model. | Journal of vascular and interventional radiology : JVIR 20040301 |
| Herpes zoster during treatment with arsenic trioxide. | Annals of hematology 20040301 |
| [Cytotoxic effects of arsenic trioxide in combination with chemotherapeutic drugs on acute non-promyelocytic leukemia cells]. | Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20040301 |
| 45th Annual Meeting of the American Society of Hematology December 6-9, 2003. | Clinical lymphoma 20040301 |
| Dicoumarol alters cellular redox state and inhibits nuclear factor kappa B to enhance arsenic trioxide-induced apoptosis. | Acta biochimica et biophysica Sinica 20040301 |
| RWJ-241947 (MCC-555), a unique peroxisome proliferator-activated receptor-gamma ligand with antitumor activity against human prostate cancer in vitro and in beige/nude/ X-linked immunodeficient mice and enhancement of apoptosis in myeloma cells induced by arsenic trioxide. | Clinical cancer research : an official journal of the American Association for Cancer Research 20040215 |
| Arsenic trioxide-induced apoptosis is independent of CD95 in lymphatic cell lines. | Oncology reports 20040201 |
| The cell cycle related apoptotic susceptibility to arsenic trioxide is associated with the level of reactive oxygen species. | Cell research 20040201 |
| [Targeted in therapies multiple myeloma]. | Zhonghua nei ke za zhi 20040201 |
| 12-O-tetradecanoylphorbol-13-acetate may both potentiate and decrease the generation of apoptosis by the antileukemic agent arsenic trioxide in human promonocytic cells. Regulation by extracellular signal-regulated protein kinases and glutathione. | The Journal of biological chemistry 20040130 |
| Unusual effects of a QT-prolonging drug, arsenic trioxide, on cardiac potassium currents. | Circulation 20040106 |
| In vitro efficacy of combined treatment depends on the underlying mechanism of resistance in imatinib-resistant Bcr-Abl-positive cell lines. | Blood 20040101 |
| Arsenic speciation in urine from acute promyelocytic leukemia patients undergoing arsenic trioxide treatment. | Chemical research in toxicology 20040101 |
| Depolarization of mitochondria and activation of caspases are common features of arsenic(III)-induced apoptosis in myelogenic and lymphatic cell lines. | Chemical research in toxicology 20040101 |
| Emodin enhances arsenic trioxide-induced apoptosis via generation of reactive oxygen species and inhibition of survival signaling. | Cancer research 20040101 |
| [Inhibition effect of arsenic trioxide on the growth of human MDS cell line MUTZ-1 cells]. | Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20040101 |
| [Clinical and experimental study of cardiac effects of conventional dosage arsenic trioxide in APL patients]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20040101 |
| [Successful bone marrow transplantation with a matched unrelated donor in an acute promyelocytic leukemia patient after reinduction therapy with arsenic trioxide]. | [Rinsho ketsueki] The Japanese journal of clinical hematology 20040101 |
| Cytotoxic effects of B lymphocytes mediated by reactive oxygen species. | Current pharmaceutical design 20040101 |
| Prevention and management of cardiotoxicity from antineoplastic therapy. | The journal of supportive oncology 20040101 |
| Arsenic trioxide causes redistribution of cell cycle, caspase activation, and GADD expression in human colonic, breast, and pancreatic cancer cells. | Cancer investigation 20040101 |
| Survival after a lethal dose of arsenic trioxide. | Journal of toxicology. Clinical toxicology 20040101 |
| Arsenic trioxide inhibits proliferation in K562 cells by changing cell cycle and survivin expression. | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20040101 |
| Preparation of arsenic trioxide-loaded microemulsion and its enhanced cytotoxicity on MCF-7 breast carcinoma cell line. | Drug delivery 20040101 |
| Arsenic enhances the activation of Stat1 by interferon gamma leading to synergistic expression of IRF-1. | Oncogene 20031211 |
| [Mechanism of arsenic trioxide-induced cytotoxicity on multiple myeloma cells]. | Ai zheng = Aizheng = Chinese journal of cancer 20031201 |
| [Application of arsenic trioxide in comprehensive therapy of liver carcinoma]. | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20031201 |
| [Recent advances in the treatment of acute myelogenous leukemia: a view of the new agents]. | [Rinsho ketsueki] The Japanese journal of clinical hematology 20031201 |
| Arsenic trioxide inhibits translation of mRNA of bcr-abl, resulting in attenuation of Bcr-Abl levels and apoptosis of human leukemia cells. | Cancer research 20031115 |
| Sustained activation of c-jun-terminal kinase (JNK) is closely related to arsenic trioxide-induced apoptosis in an acute myeloid leukemia (M2)-derived cell line, NKM-1. | Leukemia 20031101 |
| Arsenic trioxide uses caspase-dependent and caspase-independent death pathways in myeloma cells. | Molecular cancer therapeutics 20031101 |
| [Study on cardiac toxicity in acute promyelocyte leukemia treatment of arsenic trioxide intravenous infusion in general dose]. | Zhonghua nei ke za zhi 20031101 |
| Effect of arsenic trioxide on cytokine expression by acute promyelocytic leukemia cells. | Chinese medical journal 20031101 |
| Arsenic trioxide inhibits p-glycoprotein expression in multidrug-resistant human leukemia cells that overexpress the MDR1 gene. | Chinese medical journal 20031101 |
| Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2). | Cellular and molecular biology (Noisy-le-Grand, France) 20031101 |
| [Effect and mechanism of arsenic trioxide on chemosensitivity of human lung adenocarcinoma cells]. | Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20031101 |
| [Construction of subtracted cDNA library in human Jurkat T cell line induced by arsenic trioxide in vitro]. | Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20031101 |
| Bibliography. Current world literature. Therapeutic modalities. | Current opinion in oncology 20031101 |
| Tetraarsenic oxide induces apoptosis in U937 leukemic cells through a reactive oxygen species-dependent pathway. | International journal of oncology 20031001 |
| Effect of arsenic trioxide on QT interval in patients with advanced malignancies. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20031001 |
| [Effects of As2O3 on tissue factor, plasminogen activator inhibitor-1 and -2 expression in NB4, HL-60 and THP-1 cells]. | Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20031001 |
| Arsenic trioxide induces apoptosis of cutaneous T cell lymphoma cells: evidence for a partially caspase-independent pathway and potentiation by ascorbic acid (vitamin C). | The Journal of investigative dermatology 20031001 |
| Novel biospecific agents for the treatment of myelodysplastic syndromes. | Journal of the National Comprehensive Cancer Network : JNCCN 20031001 |
| New agents in chronic myelogenous leukemia. | Journal of the National Comprehensive Cancer Network : JNCCN 20031001 |
| Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism. | The Journal of biological chemistry 20030926 |
| [Expanding possibilities, strategic considerations, and novel methods in the diagnosis and chemotherapy of adult acute myeloid leukemia]. | Orvosi hetilap 20030907 |
| Ezrin, actin and cytoskeleton in apoptosis of esophageal epithelial cells induced by arsenic trioxide. | International journal of molecular medicine 20030901 |
| Prolonged molecular remission after arsenic trioxide and all-trans retinoic acid for acute promyelocytic leukemia relapsed after allogeneic stem cell transplantation. | Leukemia 20030901 |
| Therapy strategies for multiple myeloma: current status. | Wiener klinische Wochenschrift 20030814 |
| Increasing sensitivity to arsenic trioxide-induced apoptosis by altered telomere state. | European journal of pharmacology 20030808 |
| Inhibition of NF-kappaB essentially contributes to arsenic-induced apoptosis. | Blood 20030801 |
| Arsenic trioxide induces apoptosis in pancreatic cancer cells via changes in cell cycle, caspase activation, and GADD expression. | Pancreas 20030801 |
| Arsenic trioxide induces apoptosis in peripheral blood T lymphocyte subsets by inducing oxidative stress: a role of Bcl-2. | Molecular cancer therapeutics 20030801 |
| [Inhibiting effect of arsenic trioxide on telomerase activity of NB4 and Jurkat cell lines]. | Zhongguo shi yan xue ye xue za zhi 20030801 |
| Recent developments and future directions in the treatment of multiple myeloma. | Cancer biotherapy & radiopharmaceuticals 20030801 |
| Patterns of gene expressions induced by arsenic trioxide in cultured human fibroblasts. | Toxicology letters 20030720 |
| Arsenic trioxide induces apoptosis in cells of MOLT-4 and its daunorubicin-resistant cell line via depletion of intracellular glutathione, disruption of mitochondrial membrane potential and activation of caspase-3. | Cancer chemotherapy and pharmacology 20030701 |
| Arsenic trioxide-induced mitotic arrest and apoptosis in acute promyelocytic leukemia cells. | Leukemia 20030701 |
| Gene expression profile changes in NB4 cells induced by arsenic trioxide. | Acta pharmacologica Sinica 20030701 |
| MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity. | Molecular cancer therapeutics 20030701 |
| Treatment of acute promyelocytic leukemia and other hematologic malignancies with arsenic trioxide: review of clinical and basic studies. | International journal of hematology 20030701 |
| Docosahexaenoic acid enhances arsenic trioxide-mediated apoptosis in arsenic trioxide-resistant HL-60 cells. | Blood 20030615 |
| Combined treatment with arsenic trioxide and all-trans-retinoic acid in patients with relapsed acute promyelocytic leukemia. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030615 |
| Arsenic/interferon specifically reverses 2 distinct gene networks critical for the survival of HTLV-1-infected leukemic cells. | Blood 20030601 |
| Arsenic trioxide-induced apoptosis in myeloma cells: p53-dependent G1 or G2/M cell cycle arrest, activation of caspase-8 or caspase-9, and synergy with APO2/TRAIL. | Blood 20030515 |
| Effect of arsenic trioxide on rat hepatocellular carcinoma and its renal cytotoxity. | World journal of gastroenterology 20030515 |
| Promyelocytic leukemia protein (PML) functions as a glucocorticoid receptor co-activator by sequestering Daxx to the PML oncogenic domains (PODs) to enhance its transactivation potential. | The Journal of biological chemistry 20030502 |
| Arsenic trioxide in comparison with chemotherapy and bone marrow transplantation for the treatment of relapsed acute promyelocytic leukaemia. | Annals of oncology : official journal of the European Society for Medical Oncology 20030501 |
| Use of arsenic trioxide (As2O3) in the treatment of patients with acute promyelocytic leukemia: the M. D. Anderson experience. | Cancer 20030501 |
| Induction of autophagic cell death in malignant glioma cells by arsenic trioxide. | Cancer research 20030501 |
| Glutathione depletion overcomes resistance to arsenic trioxide in arsenic-resistant cell lines. | Leukemia 20030501 |
| Targeted therapies for the treatment of leukemia. | Seminars in oncology nursing 20030501 |
| [Effect of endogenous TGF-beta1 and TNF-alpha on the As(2)O(3) inducing apoptosis of HL-60 cells]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20030501 |
| Arsenic trioxide-induced apoptosis is independent of stress-responsive signaling pathways but sensitive to inhibition of inducible nitric oxide synthase in HepG2 cells. | Experimental & molecular medicine 20030430 |
| Methylated metabolites of arsenic trioxide are more potent than arsenic trioxide as apoptotic but not differentiation inducers in leukemia and lymphoma cells. | Cancer research 20030415 |
| Reactive oxygen species and antioxidants in apoptosis of esophageal cancer cells induced by As2O3. | International journal of molecular medicine 20030401 |
| Sustained molecular remission in advanced acute promyelocytic leukemia with combined pulsed retinoic acid and arsenic trioxide. Clinical evidence of synergistic effect and real-time quantification of minimal residual disease. | Haematologica 20030401 |
| [Effects of arsenic trioxide on cell cycle and expression of cyclin dependent kinase inhibitors of multiple myeloma cells]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20030401 |
| The human herpes virus 8-encoded viral FLICE inhibitory protein protects against growth factor withdrawal-induced apoptosis via NF-kappa B activation. | Blood 20030301 |
| Reactive oxygen species are involved in arsenic trioxide inhibition of pyruvate dehydrogenase activity. | Chemical research in toxicology 20030301 |
| P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) are induced by arsenic trioxide (As(2)O(3)), but are not the main mechanism of As(2)O(3)-resistance in acute promyelocytic leukemia cells. | Leukemia 20030301 |
| [Successful treatment after acute promyelocytic leukemia (APL) syndrome of relapsed API with arsenic trioxide]. | Gan to kagaku ryoho. Cancer & chemotherapy 20030301 |
| Arsenic trioxide induces apoptosis of rat hepatocellular carcinoma cells in vivo. | Journal of experimental & clinical cancer research : CR 20030301 |
| Arsenic species excretion after dimercaptopropanesulfonic acid (DMPS) treatment of an acute arsenic trioxide poisoning. | Archives of toxicology 20030201 |
| Arsenic trioxide induces apoptosis equally in T lymphoblastoid leukemia MOLT-4 cells and P-gp-expressing daunorubicin-resistant MOLT-4 cells. | Cancer chemotherapy and pharmacology 20030201 |
| [Effect of arsenic trioxide on the expression of cyclins gene in HL60 cells]. | Zhonghua nei ke za zhi 20030201 |
| Synergistic effect of cell differential agent-II and arsenic trioxide on induction of cell cycle arrest and apoptosis in hepatoma cells. | World journal of gastroenterology 20030115 |
| Arsenic trioxide inhibits the growth of A498 renal cell carcinoma cells via cell cycle arrest or apoptosis. | Biochemical and biophysical research communications 20030103 |
| Blockage of multidrug resistance-associated proteins potentiates the inhibitory effects of arsenic trioxide on CYP1A1 induction by polycyclic aromatic hydrocarbons. | The Journal of pharmacology and experimental therapeutics 20030101 |
| Novel therapies for multiple myeloma. | British journal of haematology 20030101 |
| Clinical activity of arsenic trioxide in Burkitt-like lymphoma. | Leukemia 20030101 |
| An exploratory investigation of the effect of arsenic trioxide on anti-Gal antibody production in baboons. | Xenotransplantation 20030101 |
| [In vitro study of the effects of arsenic trioxide combined with 8-CPT-cAMP on differentiation induction in retinoic acid resistant acute promyelocytic leukemia cells]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20030101 |
| [Clinical observation of the short-term efficacy of the treatment with combination of all-trans retinoic acid (ATRA) and arsenic trioxide (As2O3) in newly diagnosed acute promyelocytic leukemia (APL)]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20030101 |
| [Arsenic trioxide inhibits P-glycoprotein expression in multidrug-resistant human leukemia K562/ADM cell line that overexpresses mdr-1 gene and enhances their chemotherapeutic sensitivity]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20030101 |
| [Preliminary observation of the combination of arsenic trioxide and all-trans retinoic acid for the treatment of acute promyelocytic leukemia]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20030101 |
| Arsenic trioxide induces apoptosis in leukemia/lymphoma cell lines via the CD95/CD95L system. | Oncology reports 20030101 |
| Arsenic trioxide (trisenox) therapy for acute promyelocytic leukemia in the setting of hematopoietic stem cell transplantation. | The oncologist 20030101 |
| [Arsenic trioxide in the treatment of acute promyelocytic leukaemia]. | Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20030101 |
| Arsenic trioxide selectively induces early and extensive apoptosis via the APO2/caspase-8 pathway engaging the mitochondrial pathway in myeloma cells with mutant p53. | Cell cycle (Georgetown, Tex.) 20030101 |
| P53-induced gene 11 (PIG11) involved in arsenic trioxide-induced apoptosis in human gastric cancer MGC-803 cells. | Oncology reports 20030101 |
| Effect of Ad-p16 combined with CDDP or As2O3 on human bladder cancer cells. | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20030101 |
| The molecular mechanism of arsenic trioxide-induced apoptosis and oncosis in leukemia/lymphoma cell lines. | Acta haematologica 20030101 |
| Modulation of the arsenic effects on cytotoxicity, viability, and cell cycle in porcine endothelial cells by selenium. | Endothelium : journal of endothelial cell research 20030101 |
| Multiple myeloma: increasing our treatment options. | Cancer control : journal of the Moffitt Cancer Center 20030101 |
| Understanding novel therapeutic agents for multiple myeloma. | Clinical journal of oncology nursing 20030101 |
| Bcl-2 antisense oligodeoxynucleotide increases the sensitivity of leukemic cells to arsenic trioxide. | Cell biology international 20030101 |
| Early relapse after non myeloablative allogeneic stem cell transplantation in a patient with acute promyelocytic leukemia in complete molecular remission. | Indian journal of cancer 20030101 |
| Arsenic trioxide promotes histone H3 phosphoacetylation at the chromatin of CASPASE-10 in acute promyelocytic leukemia cells. | The Journal of biological chemistry 20021220 |
| Potassium antimonyl tartrate induces caspase- and reactive oxygen species-dependent apoptosis in lymphoid tumoral cells. | British journal of haematology 20021201 |
| Targeting the mitochondria: an exciting new approach to myeloma therapy. Commentary re: N. J. Bahlis et al., Feasibility and correlates of arsenic trioxide combined with ascorbic acid-mediated depletion of intracellular glutathione for the treatment of relapsed/refractory multiple myeloma. Clin. Cancer Res., 8: 3658-3668, 2002. | Clinical cancer research : an official journal of the American Association for Cancer Research 20021201 |
| Feasibility and correlates of arsenic trioxide combined with ascorbic acid-mediated depletion of intracellular glutathione for the treatment of relapsed/refractory multiple myeloma. | Clinical cancer research : an official journal of the American Association for Cancer Research 20021201 |
| [Arsenic trioxide induced p15INK4B gene expression in myelodysplastic syndrome cell line MUTZ-1]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20021201 |
| Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to arsenic trioxide. | The Journal of biological chemistry 20021122 |
| Two cases of therapy-related acute promyelocytic leukemia (t-APL) after mantle cell lymphoma and gestational trophoblastic disease. | Annals of hematology 20021101 |
| [Arsenic trioxide induced apoptosis and expression of p53 and bcl-2 genes in human small cell lung cancer cells]. | Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20021101 |
| Effect of arsenic trioxide on inhibition of restenosis after rabbit vascular injury and its mechanism. | Chinese medical journal 20021101 |
| Drug specific resistance to oxaliplatin is associated with apoptosis defect in a cellular model of colon carcinoma. | FEBS letters 20021009 |
| Inhibition by arsenic trioxide of human hepatoma cell growth. | Cancer letters 20020926 |
| Involvement of tumor necrosis factor (TNF-alpha) in arsenic trioxide induced apoptotic cell death of murine myeloid leukemia cells. | Toxicology letters 20020905 |
| Management of acute promyelocytic leukemia. | Current oncology reports 20020901 |
| Novel therapies for multiple myeloma. | Blood reviews 20020901 |
| Arsenic trioxide-induced apoptosis in U937 cells involve generation of reactive oxygen species and inhibition of Akt. | International journal of oncology 20020901 |
| Arsenic trioxide produces polymerization of microtubules and mitotic arrest before apoptosis in human tumor cell lines. | Molecular pharmacology 20020901 |
| How acute promyelocytic leukaemia revived arsenic. | Nature reviews. Cancer 20020901 |
| Targeted removal of PML-RARalpha protein is required prior to inhibition of histone deacetylase for overcoming all-trans retinoic acid differentiation resistance in acute promyelocytic leukemia. | Blood 20020801 |
| Cytotoxicity of arsenic trioxide to transitional carcinoma cells. | Urology 20020801 |
| Arsenic trioxide: acute promyelocytic leukemia and beyond. | Leukemia & lymphoma 20020801 |
| [Impact of arsenic trioxide on proliferation and metastasis of drug-resistant human ovarian carcinoma cell line]. | Ai zheng = Aizheng = Chinese journal of cancer 20020801 |
| Arsenic trioxide inhibits growth of human multiple myeloma cells in the bone marrow microenvironment. | Molecular cancer therapeutics 20020801 |
| Arsenic trioxide induces apoptosis in chronic myelogenous leukemia K562 cells: possible involvement of p38 MAP kinase. | Journal of biochemistry and molecular biology 20020731 |
| Arsenic trioxide induces apoptosis through a reactive oxygen species-dependent pathway and loss of mitochondrial membrane potential in HeLa cells. | International journal of oncology 20020701 |
| [Apoptosis of drug-resistant human ovarian carcinoma cell line 3AO/cDDP induced by arsenic trioxide and its mechanism]. | Zhonghua yi xue za zhi 20020701 |
| In vitro studies of the combination of imatinib mesylate (Gleevec) and arsenic trioxide (Trisenox) in chronic myelogenous leukemia. | Experimental hematology 20020701 |
| Arsenic trioxide in the mechanism of drug resistance reversal in MCF-7/ADM cell line of human breast cancer. | Zhonghua zhong liu za zhi [Chinese journal of oncology] 20020701 |
| The inherent cellular level of reactive oxygen species: one of the mechanisms determining apoptotic susceptibility of leukemic cells to arsenic trioxide. | Apoptosis : an international journal on programmed cell death 20020601 |
| P-glycoprotein in acute myeloid leukaemia: therapeutic implications of its association with both a multidrug-resistant and an apoptosis-resistant phenotype. | Leukemia & lymphoma 20020601 |
| [The comparison between the mechanisms of sodium selenite induced apoptosis and arsenic trioxide induced apoptosis in human acute promyelocytic leukemia cell line NB4 cells]. | Zhongguo shi yan xue ye xue za zhi 20020601 |
| In vitro and in vivo effectiveness of arsenic trioxide against murine T-cell prolymphocytic leukaemia. | British journal of haematology 20020501 |
| Arsenic trioxide therapy for relapsed acute promyelocytic leukemia: a bridge to transplantation. | Haematologica 20020501 |
| Arsenic trioxide and breast cancer: analysis of the apoptotic, differentiative and immunomodulatory effects. | Breast cancer research and treatment 20020501 |
| [Diamide and cyclosporin A enhanced arsenic trioxide-induced apoptosis in NB4 cells]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20020501 |
| Arsenic trioxide induces apoptosis in HTLV-I infected T-cell lines and fresh adult T-cell leukemia cells through CD95 or tumor necrosis factor alpha receptor independent caspase activation. | Leukemia & lymphoma 20020501 |
| Liposomal-all-trans-retinoic acid in treatment of acute promyelocytic leukemia. | Leukemia & lymphoma 20020501 |
| Arsenic trioxide and methylprednisolone use different signal transduction pathways in leukemic differentiation. | Leukemia research 20020401 |
| Mitochondria, calcium and nitric oxide in the apoptotic pathway of esophageal carcinoma cells induced by As2O3. | International journal of molecular medicine 20020401 |
| Combined arsenic trioxide and all-trans retinoic acid treatment for acute promyelocytic leukaemia recurring from previous relapses successfully treated using arsenic trioxide. | British journal of haematology 20020401 |
| Arsenic trioxide therapy for relapsed or refractory Japanese patients with acute promyelocytic leukemia: need for careful electrocardiogram monitoring. | Leukemia 20020401 |
| Arsenic trioxide: mechanisms of action. | Seminars in hematology 20020401 |
| Established practice in the treatment of patients with acute promyleocytic leukemia and the introduction of arsenic trioxide as a novel therapy. | Seminars in hematology 20020401 |
| Recent advances in Philadelphia chromosome-positive malignancies: the potential role of arsenic trioxide. | Seminars in hematology 20020401 |
| The MRP1-mediated effluxes of arsenic and antimony do not require arsenic-glutathione and antimony-glutathione complex formation. | Journal of bioenergetics and biomembranes 20020401 |
| Apoptosis susceptibility of tumor cells to arsenic trioxide and the inherent cellular level of reactive oxygen species. | Chinese medical journal 20020401 |
| Arsenic trioxide, retinoic acid and Ara-c regulated the expression of annexin II on the surface of APL cells, a novel co-receptor for plasminogen/tissue plasminogen activator. | Thrombosis research 20020401 |
| [Experimental study of low dose arsenic trioxide in treatment of patients with acute promyelocytic leukemia]. | Ai zheng = Aizheng = Chinese journal of cancer 20020401 |
| [Primary study of arsenic trioxide inhibits abdomino-metastatic tumor formation of human ovarian carcinoma in nude mice and its mechanisms]. | Ai zheng = Aizheng = Chinese journal of cancer 20020401 |
| Arsenic trioxide-induced apoptosis through oxidative stress in cells of colon cancer cell lines. | Life sciences 20020329 |
| Arsenic trioxide-induced apoptosis and its enhancement by buthionine sulfoximine in hepatocellular carcinoma cell lines. | Biochemical and biophysical research communications 20020308 |
| Arsenic trioxide as a novel anticancer agent against human transitional carcinoma--characterizing its apoptotic pathway. | Anti-cancer drugs 20020301 |
| [Detection of cell apoptosis by MTT assay]. | Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20020301 |
| Acute promyelocytic leukemia: evolving therapeutic strategies. | Blood 20020201 |
| Synergic effects of arsenic trioxide and cAMP during acute promyelocytic leukemia cell maturation subtends a novel signaling cross-talk. | Blood 20020201 |
| Arsenic trioxide cytotoxicity in steroid and chemotherapy-resistant myeloma cell lines: enhancement of apoptosis by manipulation of cellular redox state. | Clinical cancer research : an official journal of the American Association for Cancer Research 20020201 |
| Arsenic trioxide (As(2)O(3)) induced apoptosis and its mechanisms in a human esophageal squamous carcinoma cell line. | Chinese medical journal 20020201 |
| [The expression of Fas, FasL and Bcl-2 on RMA cells during the process of apoptosis induced by chemotherapeutic drugs]. | Zhongguo shi yan xue ye xue za zhi 20020201 |
| [Advances in the study on the effects of Chinese herbal drugs on apoptosis]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020201 |
| Multiple myeloma: present and future. | Current opinion in oncology 20020101 |
| Advances in the treatment of relapsed acute promyelocytic leukemia. | Acta haematologica 20020101 |
| Opposite biological effects of arsenic trioxide and arsacetin involve a different regulation of signaling in human gastric cancer MGC-803 cells. | Pharmacology 20020101 |
| Arsonoliposomes, a novel class of arsenic-containing liposomes: effect of palmitoyl-arsonolipid-containing liposomes on the viability of cancer and normal cells in culture. | Pharmaceutical research 20020101 |
| Advances in the management of acute promyelocytic leukemia and other hematologic malignancies with arsenic trioxide. | The oncologist 20020101 |
| Molecular targets of arsenic trioxide in malignant cells. | The oncologist 20020101 |
| Nontraditional cytotoxic therapies for relapsed/refractory multiple myeloma. | The oncologist 20020101 |
| Multifaceted approach to the treatment of bcr-abl-positive leukemias. | The oncologist 20020101 |
| New approaches to the treatment of myelodysplasia. | The oncologist 20020101 |
| Functional repression of estrogen receptor a by arsenic trioxide in human breast cancer cells. | Anticancer research 20020101 |
| [Ascorbic acid enhances the apoptosis of U937 cells induced by arsenic trioxide in combination with DMNQ and its mechanism]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20020101 |
| Pifithrin-alpha (PFT-alpha) caused differential protection of rat liver cells and HepG2 cell line in response to the selective cytotoxicity of arsenic and cadmium. | Biomedical sciences instrumentation 20020101 |
| [Are mitochondria targets of anticancer drugs responsible for apoptosis?]. | Annales de biologie clinique 20020101 |
| Arsenic trioxide inhibits proliferation and induces apoptosis in pancreatic cancer cells. | Anticancer research 20020101 |
| Myocardial toxicity of arsenic trioxide in a mouse model. | Cardiovascular toxicology 20020101 |
| Arsenic trioxide arrests cells early in mitosis leading to apoptosis. | Cell cycle (Georgetown, Tex.) 20020101 |
| Arsenic trioxide as effective therapy for relapsed acute promyelocytic leukemia. | Clinical journal of oncology nursing 20020101 |
| Treatment of acute promyelocytic leukemia with ATRA and As2O3: a model of molecular target-based cancer therapy. | Cancer biology & therapy 20020101 |
| Arsenic trioxide induces apoptosis in human T-cell leukemia virus type 1- and type 2-infected cells by a caspase-3-dependent mechanism involving Bcl-2 cleavage. | Blood 20011215 |
| [The impact of arsenic trioxide or all-trans retinoic acid treatment on coagulopathy in acute promyelocytic leukemia]. | Zhonghua nei ke za zhi 20011201 |
| APL, a model disease for cancer therapies? | Oncogene 20011029 |
| Arsenic trioxide, a therapeutic agent for APL. | Oncogene 20011029 |
| Pathways of retinoic acid- or arsenic trioxide-induced PML/RARalpha catabolism, role of oncogene degradation in disease remission. | Oncogene 20011029 |
| United States multicenter study of arsenic trioxide in relapsed acute promyelocytic leukemia. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010915 |
| Arsenic trioxide induces G2/M growth arrest and apoptosis after caspase-3 activation and bcl-2 phosphorylation in promonocytic U937 cells. | Biochemical and biophysical research communications 20010831 |
| Ascorbic acid enhances arsenic trioxide-induced cytotoxicity in multiple myeloma cells. | Blood 20010801 |
| A novel differentiation-inducing therapy for acute promyelocytic leukemia with a combination of arsenic trioxide and GM-CSF. | Leukemia 20010801 |
| Histone deacetylases and transcriptional therapy with their inhibitors. | Cancer chemotherapy and pharmacology 20010801 |
| Down-regulation of four arsenic antagonists on apoptosis and telomerase activity induced by arsenic trioxide in three myelocytic leukemia cell lines. | Acta pharmacologica Sinica 20010801 |
| Tumor growth inhibition by arsenic trioxide (As2O3) in the orthotopic metastasis model of androgen-independent prostate cancer. | Cancer research 20010715 |
| Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor alpha degradation. | The Journal of experimental medicine 20010618 |
| Mitochondria-targeting drugs arsenic trioxide and lonidamine bypass the resistance of TPA-differentiated leukemic cells to apoptosis. | Blood 20010615 |
| Resistance of human multidrug resistance-associated protein 1-overexpressing lung tumor cells to the anticancer drug arsenic trioxide. | Biochemical pharmacology 20010601 |
| Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL. | Nature medicine 20010601 |
| Arsenic compounds induce cytotoxicity and apoptosis in cisplatin-sensitive and -resistant gynecological cancer cell lines. | Cancer chemotherapy and pharmacology 20010601 |
| Atrazine potentiation of arsenic trioxide-induced cytotoxicity and gene expression in human liver carcinoma cells (HepG2). | Molecular and cellular biochemistry 20010601 |
| Apoptosis induced by arsenic trioxide in leukemia U937 cells is dependent on activation of p38, inactivation of ERK and the Ca2+-dependent production of superoxide. | International journal of cancer 20010515 |
| Co-treatment with As2O3 enhances selective cytotoxic effects of STI-571 against Brc-Abl-positive acute leukemia cells. | Leukemia 20010501 |
| Effects of all-trans-retinoic acid and arsenic trioxide on the hemostatic disturbance associated with acute promyelocytic leukemia. | Thrombosis research 20010501 |
| [Mechanisms of arsenic trioxide-induced apoptosis in myeloma cells]. | Zhonghua zhong liu za zhi [Chinese journal of oncology] 20010501 |
| Stimulation of IGF-binding protein-1 secretion by AMP-activated protein kinase. | Biochemical and biophysical research communications 20010420 |
| Arsenic trioxide- and idarubicin-induced remissions in relapsed acute promyelocytic leukaemia: clinicopathological and molecular features of a pilot study. | American journal of hematology 20010401 |
| Apoptosis inducing effects of arsenic trioxide on human bladder cancer cell line BIU-87. | Chinese medical journal 20010401 |
| Arsenic trioxide and ascorbic acid: synergy with potential implications for the treatment of acute myeloid leukaemia? | British journal of haematology 20010301 |
| XAS applied to pharmaceuticals: drug administration and bioavailability. | Journal of synchrotron radiation 20010301 |
| Arsenic trioxide induces apoptosis in human gastric cancer cells through up-regulation of p53 and activation of caspase-3. | International journal of cancer 20010115 |
| Combined effect of all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia cells in vitro and in vivo. | Blood 20010101 |
| Acute progranulocytic leukemia. | Current opinion in oncology 20010101 |
| Drug approval summaries: arsenic trioxide, tamoxifen citrate, anastrazole, paclitaxel, bexarotene. | The oncologist 20010101 |
| Treatment of acute promyelocytic leukemia with arsenic compounds: in vitro and in vivo studies. | Seminars in hematology 20010101 |
| Alteration of nuclear matrix protein composition of neuroblastoma cells after arsenic trioxide treatment. | Anticancer research 20010101 |
| Intentional overdose of dimercaptosuccinic acid in the course of treatment for arsenic poisoning. | Journal of toxicology. Clinical toxicology 20010101 |
| Clinical experience of arsenic trioxide in relapsed acute promyelocytic leukemia. | The oncologist 20010101 |
| Risk/benefit profile of arsenic trioxide. | The oncologist 20010101 |
| Retinoic acid dramatically enhances the arsenic trioxide-induced cell cycle arrest and apoptosis in retinoic acid receptor alpha-positive human T-cell lymphotropic virus type-I-transformed cells. | The hematology journal : the official journal of the European Haematology Association 20010101 |
| ATRA(ouble) in the treatment of acute promyelocytic leukemia. | Journal of biological regulators and homeostatic agents 20010101 |
| Arsenic trioxide in the management of acute promyelocytic leukaemia. | The National medical journal of India 20010101 |
| Studies of apoptosis of malignant lymphoma cells induced by arsenic trioxide. | Cell biology international 20010101 |
| Arsenic trioxide induces multiple myeloma cell apoptosis via disruption of mitochondrial transmembrane potentials and activation of caspase-3. | Chinese medical journal 20010101 |
| Effect of all-trans retinoic acid and arsenic trioxide on tissue factor expression in acute promyelocytic leukemia cells. | Chinese medical journal 20010101 |
| [A study of tissue factor expression and hemostatic molecular markers in patients with acute promyelocytic leukemia]. | Zhonghua nei ke za zhi 20010101 |
| [p15 gene expression in acute lymphoblastic leukemia cell line Molt4 induced by arsenic trioxide]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20010101 |
| Treatment of acute promyelocytic leukemia with arsenic trioxide: clinical and basic studies. | Leukemia & lymphoma 20010101 |
| Arsenic trioxide: a new immunomodulatory agent in the management of multiple myeloma. | Medical oncology (Northwood, London, England) 20010101 |
| [An experimental study on arsenic trioxide-selectively induced human hepatocarcinoma cell lines apoptosis and its related genes]. | Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20001201 |
| Arsenic trioxide inhibits neuroblastoma growth in vivo and promotes apoptotic cell death in vitro. | Biochemical and biophysical research communications 20001014 |
| Pathologic, cytogenetic and molecular assessment of acute promyelocytic leukemia patients treated with arsenic trioxide (As2O3). | Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 20000901 |
| [Experimental study on combination of Ad-p53 with CDDP or As(2)O(3) in human lung adenocarcinoma cell line GLC-82]. | Zhonghua yi xue za zhi 20000901 |
| Retinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARalpha and PLZF-RARalpha oncoproteins. | Proceedings of the National Academy of Sciences of the United States of America 20000829 |
| Arsenic trioxide-mediated growth inhibition in MC/CAR myeloma cells via cell cycle arrest in association with induction of cyclin-dependent kinase inhibitor, p21, and apoptosis. | Cancer research 20000601 |
| Arsenic trioxide (As2O3) gradually downregulates tissue factor expression without affecting thrombomodulin expression in acute promyelocytic leukemia cells. | Leukemia 20000501 |
| Arsenic trioxide and the growth of human T-cell leukemia virus type I infected T-cell lines. | Leukemia & lymphoma 20000501 |
| [Effects of all-trans retinoic acid and arsenic trioxide on tissue factor expression of acute promyelocytic leukemia cells]. | Zhonghua yi xue za zhi 20000501 |
| [Mechanism of tissue factor expression on NB4 cells down-regulated by all-trans retinoic acid and arsenic trioxide]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20000501 |
| [Arsenic trioxide induces human tumor cell apoptosis and G2 + M arrest whereas causes HPV16 DNA immortalized cervical epithelial cells G1 block]. | Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20000401 |
| Arsenic-induced apoptosis in malignant cells in vitro. | Leukemia & lymphoma 20000301 |
| Hemostatic abnormalities associated with acute promyelocytic leukemia and corrective effects of all-trans-retinoic acid or arsenic trioxide treatment. | Chinese medical journal 20000301 |
| The alteration of mitochondria is an early event of arsenic trioxide induced apoptosis in esophageal carcinoma cells. | International journal of molecular medicine 20000201 |
| Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-Abl or overexpress MDR, MRP, Bcl-2, or Bcl-x(L). | Blood 20000201 |
| Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia. | Leukemia 20000201 |
| [Antitumor effect of arsenic trioxide on mice experimental liver cancer]. | Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20000201 |
| [Arsenic trioxide induced human esophageal cancer Ec109 cell apoptosis with downregulation of c-myc gene expression]. | Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20000201 |
| As2O3 induces apoptosis of the human B lymphoma cell line MBC-1. | Journal of biological regulators and homeostatic agents 20000101 |
| Overexpression of Bcl-2 partly inhibits apoptosis of human cervical cancer SiHa cells induced by arsenic trioxide. | Chinese medical journal 20000101 |
| Preliminary study of the in vitro growth inhibition of human bladder cancer cell line BIU-87 by arsenic trioxide. | Journal of Tongji Medical University = Tong ji yi ke da xue xue bao 20000101 |
| Arsenic trioxide causes selective necrosis in solid murine tumors by vascular shutdown. | Cancer research 19991215 |
| Long-term survival and prognostic study in acute promyelocytic leukemia treated with all-trans-retinoic acid, chemotherapy, and As2O3: an experience of 120 patients at a single institution. | International journal of hematology 19991201 |
| [Effects of As2O3 on the BCR/ABL protein tyrosine phosphorylation in K562 cells]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 19991201 |
| Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: remission induction, follow-up, and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patients. | Blood 19991115 |
| Comparative effects of single intraperitoneal or oral doses of sodium arsenate or arsenic trioxide during in utero development. | Teratology 19991101 |
| Arsenic trioxide sensitivity is associated with low level of glutathione in cancer cells. | British journal of cancer 19991101 |
| Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway. | Blood 19990915 |
| [Effects of all-trans retinoic acid, arsenic trioxide and daunorubicin on tissue factor expression in NB4 cells]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 19990901 |
| [Inhibitory effects of recombinant human neurotrophin-4/5 protein on neurotoxicity caused by arsenic trioxide]. | Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 19990901 |
| Arsenic trioxide induces apoptosis of HPV16 DNA-immortalized human cervical epithelial cells and selectively inhibits viral gene expression. | International journal of cancer 19990719 |
| Arsenic trioxide induces apoptosis in neuroblastoma cell lines through the activation of caspase 3 in vitro. | FEBS letters 19990716 |
| PIC-1/SUMO-1-modified PML-retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemia. | Molecular and cellular biology 19990701 |
| Arsenic trioxide induces apoptosis of oesophageal carcinoma in vitro. | International journal of molecular medicine 19990701 |
| Dithiothreitol enhances arsenic trioxide-induced apoptosis in NB4 cells. | Molecular pharmacology 19990701 |
| Tissue factors on acute promyelocytic leukemia and endothelial cells are differently regulated by retinoic acid, arsenic trioxide and chemotherapeutic agents. | Leukemia 19990701 |
| Complete atrioventricular block after arsenic trioxide treatment in an acute promyelocytic leukemic patient. | Pacing and clinical electrophysiology : PACE 19990601 |
| Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations. | Journal of the National Cancer Institute 19990505 |
| Effect of arsenic trioxide on viability, proliferation, and apoptosis in human megakaryocytic leukemia cell lines. | Experimental hematology 19990501 |
| In acute promyelocytic leukemia NB4 cells, the synthetic retinoid CD437 induces contemporaneously apoptosis, a caspase-3-mediated degradation of PML/RARalpha protein and the PML retargeting on PML-nuclear bodies. | Leukemia 19990501 |
| Arsenic trioxide induces apoptosis of myeloid leukemia cells by activation of caspases. | Medical oncology (Northwood, London, England) 19990401 |
| Arsenic trioxide and melarsoprol induce apoptosis in plasma cell lines and in plasma cells from myeloma patients. | Cancer research 19990301 |
| [An analysis of the therapeutic effects and reactions in treating acute promyelocytic leukemia with intravenous arsenic trioxide or all-trans retinoic acid]. | Zhonghua nei ke za zhi 19990201 |
| Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide. | The New England journal of medicine 19981105 |
| Arsenic trioxide and melarsoprol induce programmed cell death in myeloid leukemia cell lines and function in a PML and PML-RARalpha independent manner. | Blood 19980901 |
| Arsenic induces apoptosis in B-cell leukaemic cell lines in vitro: activation of caspases and down-regulation of Bcl-2 protein. | British journal of haematology 19980901 |
| [Tissue factor expression during all-trans retinoic acid or arsenic trioxide treatment in acute promyelocytic leukemia]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 19980901 |
| Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cells. | Journal of the National Cancer Institute 19980121 |
| Arsenic trioxide in the treatment of a patient with multiply recurrent, ATRA-resistant promyelocytic leukemia: a case report. | Journal of pediatric hematology/oncology 19980101 |
| Comparative activity of melarsoprol and arsenic trioxide in chronic B-cell leukemia lines. | Blood 19970715 |
| Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells. | Blood 19970501 |
| Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. | Blood 19970501 |
| [Preliminary study on the arsenic trioxide-induced NB4 cell apoptosis and its molecular mechanisms]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 19970101 |
| [Effects of arsenic trioxide on the subcellular localization of PML/PML-RARalpha protein in leukemic cells]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 19970101 |
| The PML and PML/RARalpha domains: from autoimmunity to molecular oncology and from retinoic acid to arsenic. | Experimental cell research 19961215 |
| In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins. | Blood 19960801 |
| Assessment of exposure to arsenic among smelter workers: a five-year follow-up. | American journal of industrial medicine 19940401 |
| [Arsenic trioxide inhibition of the thiophosphamide induction of mutations in mouse germ and somatic cells]. | Genetika 19840201 |
| [Relationship between arsenic-induced hypothermia and brain monoamines. (2). The roles of noradrenaline and dopamine]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 19820801 |
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