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124924-85-2 | 7-(3-(3-hydroxy-4-(4'-iodophenoxy)-1-butenyl)-7-oxabicyclo(2.2.1)heptan-2-yl)-5-heptenoic acid
CAS No: 124924-85-2 Catalog No: AG00AI2Y MDL No:
Product Description
Catalog Number:
AG00AI2Y
Chemical Name:
7-(3-(3-hydroxy-4-(4'-iodophenoxy)-1-butenyl)-7-oxabicyclo(2.2.1)heptan-2-yl)-5-heptenoic acid
CAS Number:
124924-85-2
IUPAC Name:
(Z)-7-[(1S,2R,3R,4R)-3-[(E,3R)-3-hydroxy-4-(4-(125I)iodanylphenoxy)but-1-enyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid
InChI:
InChI=1S/C23H29IO5/c24-16-7-10-18(11-8-16)28-15-17(25)9-12-20-19(21-13-14-22(20)29-21)5-3-1-2-4-6-23(26)27/h1,3,7-12,17,19-22,25H,2,4-6,13-15H2,(H,26,27)/b3-1-,12-9+/t17-,19-,20-,21+,22-/m1/s1/i24-2
InChI Key:
UYFMSCHBODMWON-GEUMQUDLSA-N
Properties
Complexity:
570
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
5
Defined Bond Stereocenter Count:
2
Exact Mass:
510.106g/mol
Formal Charge:
0
Heavy Atom Count:
29
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
1
Molecular Weight:
510.385g/mol
Monoisotopic Mass:
510.106g/mol
Rotatable Bond Count:
11
Topological Polar Surface Area:
76A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4
Literature
| Title | Journal |
|---|---|
| Increased expression of matrix metalloproteinases mediates thromboxane A2-induced invasion in lung cancer cells. | Current cancer drug targets 20120701 |
| Activation of NAD(P)H oxidases by thromboxane A2 receptor uncouples endothelial nitric oxide synthase. | Arteriosclerosis, thrombosis, and vascular biology 20110101 |
| Thromboxane receptor alpha mediates tumor growth and angiogenesis via induction of vascular endothelial growth factor expression in human lung cancer cells. | Lung cancer (Amsterdam, Netherlands) 20100701 |
| Activation of thromboxane A(2) receptors induces orphan nuclear receptor Nurr1 expression and stimulates cell proliferation in human lung cancer cells. | Carcinogenesis 20090901 |
| Thromboxane A2 receptor activates a Rho-associated kinase/LKB1/PTEN pathway to attenuate endothelium insulin signaling. | The Journal of biological chemistry 20090619 |
| Activation-dependent stabilization of the human thromboxane receptor: role of reactive oxygen species. | Journal of lipid research 20090601 |
| TP receptor-mediated release of eosinophil chemotactic activity from human bronchial smooth muscle cells. | European journal of pharmacology 20081214 |
| Thromboxane receptor activates the AMP-activated protein kinase in vascular smooth muscle cells via hydrogen peroxide. | Circulation research 20080215 |
| Activation of extracellular signal-regulated kinase by 12-hydroxyheptadecatrienoic acid in prostate cancer PC3 cells. | Archives of biochemistry and biophysics 20071101 |
| Activation of thromboxane receptor alpha induces expression of cyclooxygenase-2 through multiple signaling pathways in A549 human lung adenocarcinoma cells. | Biochemical pharmacology 20070901 |
| Protection of atherogenesis in thromboxane A2 receptor-deficient mice is not associated with thromboxane A2 receptor in bone marrow-derived cells. | Biochemical and biophysical research communications 20061229 |
| Glycogen synthase kinase-3 phosphorylation, T-cell factor signaling activation, and cell morphology change following stimulation of thromboxane receptor alpha. | The Journal of pharmacology and experimental therapeutics 20060401 |
| Human bronchial smooth muscle cell proliferation via thromboxane A2 receptor. | Prostaglandins, leukotrienes, and essential fatty acids 20041201 |
| Thromboxane A2 receptor signaling inhibits vascular endothelial growth factor-induced endothelial cell differentiation and migration. | Circulation research 20040820 |
| Thromboxane A2 receptor agonists antagonize the proangiogenic effects of fibroblast growth factor-2: role of receptor internalization, thrombospondin-1, and alpha(v)beta3. | Circulation research 20040402 |
| Glibenclamide inhibits thromboxane-mediated vasoconstriction by thromboxane receptor blockade. | Vascular pharmacology 20040101 |
| Immunolocalization of P2Y1 and TPalpha receptors in platelets showed a major pool associated with the membranes of alpha -granules and the open canalicular system. | Blood 20030215 |
| A new family of thromboxane receptor antagonists with secondary thromboxane synthase inhibition. | The Journal of pharmacology and experimental therapeutics 20020501 |
| Protein kinase C-zeta modulates thromboxane A(2)-mediated apoptosis in adult ventricular myocytes via Akt. | American journal of physiology. Heart and circulatory physiology 20020101 |
| Changes in vascular responsiveness to a thromboxane mimetic in endotoxin tolerance. | Shock (Augusta, Ga.) 20011101 |
| Serine 331 is the major site of receptor phosphorylation induced by agents that activate protein kinase G in HEK 293 cells overexpressing thromboxane receptor alpha. | Archives of biochemistry and biophysics 20010901 |
| Characterization of the prostanoid TP receptor population in human nonpregnant myometrium. | The Journal of pharmacology and experimental therapeutics 19961001 |
| 7-[(1R,2S,3S,5R)-6,6-dimethyl-3-(4- iodobenzenesulfonylamino)bicyclo[3.1.1]hept-2-yl]-5(Z)-heptenoic acid: a novel high-affinity radiolabeled antagonist for platelet thromboxane A2/prostaglandin H2 receptors. | The Journal of pharmacology and experimental therapeutics 19920801 |
| Differential effect of pH on thromboxane A2/prostaglandin H2 receptor agonist and antagonist binding in human platelets. | The Journal of biological chemistry 19910725 |
| Characterization of an 125I-labeled thromboxane A2/prostaglandin H2 receptor agonist. | The Journal of pharmacology and experimental therapeutics 19891101 |
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