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1245646-84-7

1245646-84-7 | Quinoline, 2-(1-piperazinyl)-, hydrochloride (1:1)

CAS No: 1245646-84-7 Catalog No: AG000MAU MDL No:MFCD11113034

Product Description

Catalog Number:
AG000MAU
Chemical Name:
Quinoline, 2-(1-piperazinyl)-, hydrochloride (1:1)
CAS Number:
1245646-84-7
Molecular Formula:
C13H16ClN3
Molecular Weight:
249.7392
MDL Number:
MFCD11113034
IUPAC Name:
2-piperazin-1-ylquinoline;hydrochloride
InChI:
InChI=1S/C13H15N3.ClH/c1-2-4-12-11(3-1)5-6-13(15-12)16-9-7-14-8-10-16;/h1-6,14H,7-10H2;1H
InChI Key:
BWKBOZBYECIGSP-UHFFFAOYSA-N
SMILES:
N1CCN(CC1)c1ccc2c(n1)cccc2.Cl

Properties

Complexity:
225  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
249.103g/mol
Formal Charge:
0
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
249.742g/mol
Monoisotopic Mass:
249.103g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
28.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0

Literature

Title Journal
Daily passive cycling attenuates the hyperexcitability and restores the responsiveness of the extensor monosynaptic reflex to quipazine in the chronic spinally transected rat. Journal of neurotrauma 20140615
Discovery of a tetracyclic quinoxaline derivative as a potent and orally active multifunctional drug candidate for the treatment of neuropsychiatric and neurological disorders. Journal of medicinal chemistry 20140327
Sensory feedback modulates quipazine-induced stepping behavior in the newborn rat. Behavioural brain research 20120401
The upright posture improves plantar stepping and alters responses to serotonergic drugs in spinal rats. The Journal of physiology 20120401
Synthesis, in vitro binding studies and docking of long-chain arylpiperazine nitroquipazine analogues, as potential serotonin transporter inhibitors. European journal of medicinal chemistry 20120301
Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120101
Mass-spectrometric studies of new 6-nitroquipazines-serotonin transporter inhibitors. Analytical and bioanalytical chemistry 20120101
Motor deficits and recovery in rats with unilateral spinal cord hemisection mimic the Brown-Sequard syndrome. Brain : a journal of neurology 20110801
Cholesterol and lipid phases influence the interactions between serotonin receptor agonists and lipid bilayers. The Journal of biological chemistry 20101231
Why variability facilitates spinal learning. The Journal of neuroscience : the official journal of the Society for Neuroscience 20100811
Afferent inputs to mid- and lower-lumbar spinal segments are necessary for stepping in spinal cats. Annals of the New York Academy of Sciences 20100601
A novel 5-HT(2A) receptor antagonist exhibits antidepressant-like effects in a battery of rodent behavioural assays: approaching early-onset antidepressants. Pharmacology, biochemistry, and behavior 20100101
The interactions of the 5-HT3 receptor with quipazine-like arylpiperazine ligands: the journey track at the end of the first decade of the third millennium. Current topics in medicinal chemistry 20100101
Effects of serotonergic agents on survival and hemolymph composition of the larval mosquito Aedes aegypti (Diptera: Culicidae, L.) in vivo: does serotonin regulate hemolymph acid-base homeostasis? The Journal of experimental biology 20091101
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input. Nature neuroscience 20091001
Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships. Journal of medicinal chemistry 20090611
Synthesis and preliminary screening of novel N-{2-[4-(substituted)piperazin-1-yl]-2-oxoethyl}acetamides as potential atypical antipsychotic agents. Journal of enzyme inhibition and medicinal chemistry 20090601
Serotonin receptor agonist quipazine promotes proliferation and apoptosis of human hepatocyte strain of L-02 strain. Hepatobiliary & pancreatic diseases international : HBPD INT 20090601
Morphofunctional study of injured spinal cord of rats after activation of serotonergic receptors and motor load. Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20090101
Synthesis and biological evaluation of one novel technetium-99m-labeled nitroquipazine derivative as an imaging agent for serotonin transporter. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20081201
Synthesis and preliminary pharmacological evaluation of N-2-(4-(4-(2-substitutedthiazol-4-yl) piperazin-1-yl)-2-oxoethyl)acetamides as novel atypical antipsychotic agents. Bioorganic & medicinal chemistry letters 20081201
Role of spinal 5-HT2 receptor subtypes in quipazine-induced hindlimb movements after a low-thoracic spinal cord transection. The European journal of neuroscience 20081201
Dose dependence of the 5-HT agonist quipazine in facilitating spinal stepping in the rat with epidural stimulation. Neuroscience letters 20080627
Epidural spinal cord stimulation plus quipazine administration enable stepping in complete spinal adult rats. Journal of neurophysiology 20071101
Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 5: 2'-Substituted 6-nitroquipazines. Bioorganic & medicinal chemistry 20070515
Presynaptic modulation of 5-HT release in the rat septal region. Neuroscience 20070511
Behavioral and neuropharmacological evidence that serotonin crosses the blood-brain barrier in Coturnix japonica (Galliformes; Aves). Brazilian journal of biology = Revista brasleira de biologia 20070201
[Effect of local microapplication of serotoninergic drugs on membrane currents of Paracentrotus lividus early embryos]. Ontogenez 20070101
Effect of robotic-assisted treadmill training and chronic quipazine treatment on hindlimb stepping in spinally transected rats. Journal of neurotrauma 20060701
Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice. Brain research bulletin 20060615
Spinal cord-transected mice learn to step in response to quipazine treatment and robotic training. The Journal of neuroscience : the official journal of the Society for Neuroscience 20051214
Preclinical pharmacology of FMPD [6-fluoro-10-[3-(2-methoxyethyl)-4-methyl-piperazin-1-yl]-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulene]: a potential novel antipsychotic with lower histamine H1 receptor affinity than olanzapine. The Journal of pharmacology and experimental therapeutics 20051201
Is the platelet serotonin transporter different in venous vs. arterial blood? Neurochemical research 20051101
Design and synthesis of long-chain arylpiperazines with mixed affinity for serotonin transporter (SERT) and 5-HT(1A) receptor. The Journal of pharmacy and pharmacology 20051001
Effects of quipazine and m-chlorophenylbiguanide (m-CPBG) on temporal differentiation: evidence for the involvement of 5-HT2A but not 5-HT3 receptors in interval timing behaviour. Psychopharmacology 20050901
Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 4: 3-Alkyl-4-halo-6-nitroquipazines. Bioorganic & medicinal chemistry 20050815
Long-lasting recovery of locomotor function in chronic spinal rat following chronic combined pharmacological stimulation of serotonergic receptors with 8-OHDPAT and quipazine. Neuroscience letters 20050801
Hyperglycemia induced by pharmacological activation of central serotonergic pathways depends on the functional integrity of brain CRH system and 5-HT3 receptors. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20050801
N1/P2 component of auditory evoked potential reflect changes of the brain serotonin biosynthesis in rats. Nutritional neuroscience 20050801
The serotonergic agonists quipazine, CGS-12066A, and alpha-methylserotonin alter motor activity and induce hindlimb stepping in the intact and spinal rat fetus. Behavioral neuroscience 20050601
Structure-affinity relationship studies on arylpiperazine derivatives related to quipazine as serotonin transporter ligands. Molecular basis of the selectivity SERT/5HT3 receptor. Bioorganic & medicinal chemistry 20050516
Effects of quipazine and m-chlorophenylbiguanide (m-CPBG) on the discrimination of durations: evidence for the involvement of 5-HT2A but not 5-HT3 receptors. Behavioural pharmacology 20050201
Involvement of the retinohypothalamic tract in the photic-like effects of the serotonin agonist quipazine in the rat. Neuroscience 20050101
Effect of valproic acid on serotonin-2A receptor signaling in C6 glioma cells. Journal of neurochemistry 20040901
Differential effects of 5-HT1 and 5-HT2 receptor agonists on hindlimb movements in paraplegic mice. Progress in neuro-psychopharmacology & biological psychiatry 20040901
Synergistic activation of the central pattern generator for locomotion by l-beta-3,4-dihydroxyphenylalanine and quipazine in adult paraplegic mice. Neuroscience letters 20040325
Role of NMDA receptor activation in serotonin agonist-induced air-stepping in paraplegic mice. Spinal cord 20040301
Serotonin patterns locomotor network activity in the developing zebrafish by modulating quiescent periods. Journal of neurobiology 20031201
Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter: Part 3. A potential 5-HT transporter imaging agent, 3-(3-[18F]fluoropropyl)-6-nitroquipazine. Bioorganic & medicinal chemistry 20031117
5-HT1A receptors are involved in short- and long-term processes responsible for 5-HT-induced locomotor function recovery in chronic spinal rat. The European journal of neuroscience 20031001
Identification of two serine residues essential for agonist-induced 5-HT2A receptor desensitization. Biochemistry 20030916
Biochemical evidence for the presence of serotonin transporters in the rat cochlea. Hearing research 20030801
Role of 5-HT3 receptors in the mechanisms of central pain syndrome. Bulletin of experimental biology and medicine 20030601
Response of the mouse circadian system to serotonin 1A/2/7 agonists in vivo: surprisingly little. Journal of biological rhythms 20030401
Thyrotropin-releasing hormone mediates serotonin-induced secretion of GH in cattle. Domestic animal endocrinology 20030301
Synthesis, radiolabeling and preliminary biological evaluation of radiolabeled 5-methyl-6-nitroquipazine, a potential radioligand for the serotonin transporter. Bioorganic & medicinal chemistry letters 20021216
Effects of serotonin 1A agonist on acute spinal cord injury. Spinal cord 20021001
Synthesis of a fluorine-18-labelled derivative of 6-nitroquipazine, as a radioligand for the in vivo serotonin transporter imaging with PET. Bioorganic & medicinal chemistry 20020801
Metachlorophenylpiperazine (m-CPP) induced intracavernous pressure responses in anaesthetized rats. International journal of impotence research 20020801
Locomotor recovery in the chronic spinal rat: effects of long-term treatment with a 5-HT2 agonist. The European journal of neuroscience 20020801
PET examination of [(11)C]5-methyl-6-nitroquipazine, a radioligand for visualization of the serotonin transporter. Nuclear medicine and biology 20020801
Evidence for serotonergic modulation of progesterone-induced hyperphagia, depression and algesia in female mice. Brain research 20020712
Electroencephalographic activation by tacrine, deprenyl, and quipazine: cholinergic vs. non-cholinergic contributions. European journal of pharmacology 20020628
The Interactions of the 5-HT(3) receptor with arylpiperazine, tropane, and quinuclidine ligands. Current topics in medicinal chemistry 20020601
Stimulus generalization by fenfluramine in a quipazine-ketanserin drug discrimination is not dependent on indirect serotonin release. Pharmacology, biochemistry, and behavior 20020501
Serotonin sets the day state in the neurons that control coupling between the optic lobe circadian pacemakers in the cricket Gryllus bimaculatus. The Journal of experimental biology 20020501
Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-substituted 6-nitroquipazines. Bioorganic & medicinal chemistry letters 20020311
Serotonergic attenuation of the reinforcing and neurochemical effects of cocaine in squirrel monkeys. The Journal of pharmacology and experimental therapeutics 20020301
Comparison of the potency of MDL 100,907 and SB 242084 in blocking the serotonin (5-HT)(2) receptor agonist-induced increases in rat serum corticosterone concentrations: evidence for 5-HT(2A) receptor mediation of the HPA axis. Neuropharmacology 20020201
Studies on modulation of feeding behavior by atypical antipsychotics in female mice. Progress in neuro-psychopharmacology & biological psychiatry 20020201
RNA-editing of the 5-HT(2C) receptor alters agonist-receptor-effector coupling specificity. British journal of pharmacology 20010901
Acute trazodone and quipazine treatment attenuates apomorphine-induced aggressive behaviour in male rats without major impact on emotional behaviour or monoamine content post mortem. Pharmacological research 20010401
In vitro and in vivo ligand binding to the 5HT(3) serotonin receptor characterised by time-resolved fluorescence spectroscopy. Chembiochem : a European journal of chemical biology 20010302
Addition of a 5-HT receptor agonist to methylphenidate potentiates the reduction of [123I]FP-CIT binding to dopamine transporters in rat frontal cortex and hippocampus. Synapse (New York, N.Y.) 20010301
Neural circuits regulating pulsatile luteinizing hormone release in the female guinea-pig: opioid, adrenergic and serotonergic interactions. Journal of neuroendocrinology 20010301
Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives. Journal of medicinal chemistry 19980226
Similarities and differences between the subchronic and withdrawal effects of clozapine and olanzapine on forelimb force steadiness. Psychopharmacology 19970801
Neurochemical and behavioral evidence that quipazine-ketanserin discrimination is mediated by serotonin2A receptor. The Journal of pharmacology and experimental therapeutics 19951101
Ziprasidone (CP-88,059): a new antipsychotic with combined dopamine and serotonin receptor antagonist activity. The Journal of pharmacology and experimental therapeutics 19951001
The interaction of trichloroethanol with murine recombinant 5-HT3 receptors. British journal of pharmacology 19950401
REM sleep deprivation changes behavioral response to catecholaminergic and serotonergic receptor activation in rats. Pharmacology, biochemistry, and behavior 19810701
Effect of drugs influencing central 5-hydroxytryptaminergic mechanisms on morphine-induced catalepsy in the rat. The Journal of pharmacy and pharmacology 19790401
Effect of drugs influencing central serotonergic mechanisms on haloperidol-induced catalepsy. Psychopharmacology 19790329
A combination therapy of neural and glial restricted precursor cells and chronic quipazine treatment paired with passive cycling promotes quipazine-induced stepping in adult spinalized rats. The journal of spinal cord medicine

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