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124505-87-9 | 4H-Imidazo[4,5-b]pyridine-4-hexanoic acid, α-amino-2-[[(4S)-4-amino-4-carboxybutyl]amino]-, (αS)-
CAS No: 124505-87-9 Catalog No: AG000M4Y MDL No:
Product Description
Catalog Number:
AG000M4Y
Chemical Name:
4H-Imidazo[4,5-b]pyridine-4-hexanoic acid, α-amino-2-[[(4S)-4-amino-4-carboxybutyl]amino]-, (αS)-
CAS Number:
124505-87-9
Molecular Formula:
C17H26N6O4
Molecular Weight:
378.4261
IUPAC Name:
(2S)-2-amino-6-[2-[[(4S)-4-amino-4-carboxybutyl]amino]imidazo[4,5-b]pyridin-4-yl]hexanoic acid
InChI:
InChI=1S/C17H26N6O4/c18-11(15(24)25)5-1-2-9-23-10-4-7-13-14(23)22-17(21-13)20-8-3-6-12(19)16(26)27/h4,7,10-12H,1-3,5-6,8-9,18-19H2,(H,20,21)(H,24,25)(H,26,27)/t11-,12-/m0/s1
InChI Key:
AYEKKSTZQYEZPU-RYUDHWBXSA-N
SMILES:
N[C@H](C(=O)O)CCCCn1cccc2c1nc(n2)NCCC[C@@H](C(=O)O)N
UNII:
BJ4I2X2CQJ
Properties
Complexity:
494
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
2
Defined Bond Stereocenter Count:
0
Exact Mass:
378.202g/mol
Formal Charge:
0
Heavy Atom Count:
27
Hydrogen Bond Acceptor Count:
9
Hydrogen Bond Donor Count:
5
Isotope Atom Count:
0
Molecular Weight:
378.433g/mol
Monoisotopic Mass:
378.202g/mol
Rotatable Bond Count:
12
Topological Polar Surface Area:
169A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-4.7
Literature
| Title | Journal |
|---|---|
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| Two fluorescent wavelengths, 440(ex)/520(em) nm and 370(ex)/440(em) nm, reflect advanced glycation and oxidation end products in human skin without diabetes. | Diabetes technology & therapeutics 20120301 |
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| Pentosidine and increased fracture risk in older adults with type 2 diabetes. | The Journal of clinical endocrinology and metabolism 20090701 |
| Relationship between glyco-oxidation, antioxidant status and microalbuminuria in type 2 diabetic patients. | Diabetologia 20090701 |
| Assessing susceptibility to age-related macular degeneration with proteomic and genomic biomarkers. | Molecular & cellular proteomics : MCP 20090601 |
| Pentosidine accumulates in the aging vitreous body: a gender effect. | Experimental eye research 20090601 |
| Decrease in serum levels of advanced glycation end-products by short-term lifestyle modification in non-diabetic middle-aged females. | Medical science monitor : international medical journal of experimental and clinical research 20090601 |
| Advanced oxidative protein products are independently associated with endothelial function in peritoneal dialysis patients. | Nephrology (Carlton, Vic.) 20090401 |
| Immunohistochemical detection of advanced glycation end products in human bladder with specific monoclonal antibody. | International journal of urology : official journal of the Japanese Urological Association 20090401 |
| Letter by Hartog et al. regarding article, 'Advanced glycation end products accumulate in vascular smooth muscle and modify vascular but not ventricular properties in elderly hypertensive canines'. | Circulation 20090317 |
| Glycated albumin as an improved indicator of glycemic control in hemodialysis patients with type 2 diabetes based on fasting plasma glucose and oral glucose tolerance test. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20090301 |
| Measurement of pentosidine in human plasma protein by a single-column high-performance liquid chromatography method with fluorescence detection. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090301 |
| Molecular pathogenesis of Alzheimer's disease: reductionist versus expansionist approaches. | International journal of molecular sciences 20090301 |
| Relationship between baseline glycemic control and cognitive function in individuals with type 2 diabetes and other cardiovascular risk factors: the action to control cardiovascular risk in diabetes-memory in diabetes (ACCORD-MIND) trial. | Diabetes care 20090201 |
| Anti-stress activity of hydro-alcoholic extract of Eugenia caryophyllus buds (clove). | Indian journal of pharmacology 20090201 |
| Simple and sensitive method for quantification of fluorescent enzymatic mature and senescent crosslinks of collagen in bone hydrolysate using single-column high performance liquid chromatography. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090101 |
| Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. | BMC medical genomics 20090101 |
| Antioxidant status of patients on peritoneal dialysis: associations with inflammation and glycoxidative stress. | Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20090101 |
| N(epsilon)-(Carboxymethyl)lysine and Coronary Atherosclerosis-Associated Low Density Lipoprotein Abnormalities in Type 2 Diabetes: Current Status. | Journal of clinical biochemistry and nutrition 20090101 |
| Quantification of Modified Tyrosines in Healthy and Diabetic Human Urine using Liquid Chromatography/Tandem Mass Spectrometry. | Journal of clinical biochemistry and nutrition 20090101 |
| Rapid glycation with D-ribose induces globular amyloid-like aggregations of BSA with high cytotoxicity to SH-SY5Y cells. | BMC cell biology 20090101 |
| quantitative determination of collagen cross-links. | Methods in molecular biology (Clifton, N.J.) 20090101 |
| RAGE (Receptor for Advanced Glycation Endproducts), RAGE ligands, and their role in cancer and inflammation. | Journal of translational medicine 20090101 |
| Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor necrosis factor-alpha and matrix metalloproteinase-13 in human chondrocytes. | Arthritis research & therapy 20090101 |
| Developments in the scientific understanding of osteoarthritis. | Arthritis research & therapy 20090101 |
| Relationship of compartment-specific structural knee status at baseline with change in cartilage morphology: a prospective observational study using data from the osteoarthritis initiative. | Arthritis research & therapy 20090101 |
| Impact of residual renal function on plasma levels of advanced oxidation protein products and pentosidine in peritoneal dialysis patients. | Nephron. Clinical practice 20090101 |
| Pentosidine - a new biochemical marker in diabetic retinopathy. | Ophthalmic research 20090101 |
| Advanced glycation end products induce cell cycle arrest and proinflammatory changes in osteoarthritic fibroblast-like synovial cells. | Arthritis research & therapy 20090101 |
| Increased pentosidine, an advanced glycation end-product, in urine and tissue reflects disease activity in inflammatory bowel diseases. | Journal of gastroenterology and hepatology 20081201 |
| Inhibition of crystallin ascorbylation by nucleophilic compounds in the hSVCT2 mouse model of lenticular aging. | Investigative ophthalmology & visual science 20081101 |
| Antiglycative and anti-VEGF effects of s-ethyl cysteine and s-propyl cysteine in kidney of diabetic mice. | Molecular nutrition & food research 20081101 |
| Collagen maturity, glycation induced-pentosidine, and mineralization are increased following 3-year treatment with incadronate in dogs. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20080901 |
| Skin-autofluorescence, a measure of tissue advanced glycation end-products (AGEs), is related to diastolic function in dialysis patients. | Journal of cardiac failure 20080901 |
| Pentosidine accumulation in human oocytes and their correlation to age-related apoptosis. | Acta histochemica et cytochemica 20080828 |
| Increased serum endogenous secretory receptor for advanced glycation end-product (esRAGE) levels in type 2 diabetic patients with decreased renal function. | Diabetes research and clinical practice 20080801 |
| [Daily practice using the guidelines for prevention and treatment of osteoporosis. How do we realize the bone quality in routine practice using Japanese guideline for osteoporosis prevention and treatment?]. | Clinical calcium 20080801 |
| Modification of the oxidative stress biomarker AOPP assay: application in uremic samples. | Clinica chimica acta; international journal of clinical chemistry 20080717 |
| Hyperglycemia-induced reactive oxygen species toxicity to endothelial cells is dependent on paracrine mediators. | Diabetes 20080701 |
| RAGE and modulation of ischemic injury in the diabetic myocardium. | Diabetes 20080701 |
| Can serum pentosidine levels predict risk of vertebral fracture in patients with type 2 diabetes mellitus? | Nature clinical practice. Endocrinology & metabolism 20080701 |
| Structural basis of growth-related gain and age-related loss of bone strength. | Rheumatology (Oxford, England) 20080701 |
| The association of advanced glycation end-products with glutathione status. | Annals of clinical biochemistry 20080701 |
| Autoimmunity and oxidatively modified autoantigens. | Autoimmunity reviews 20080701 |
| Neurodegenerative diseases of the retina and potential for protection and recovery. | Current neuropharmacology 20080601 |
| Age and disease-related structural changes in the retinal pigment epithelium. | Clinical ophthalmology (Auckland, N.Z.) 20080601 |
| Taurine administration after appearance of proteinuria retards progression of diabetic nephropathy in rats. | The Kobe journal of medical sciences 20080523 |
| Collagen turnover in normal and degenerate human intervertebral discs as determined by the racemization of aspartic acid. | The Journal of biological chemistry 20080404 |
| Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20080401 |
| Pentosidine effects on human osteoblasts in vitro. | Annals of the New York Academy of Sciences 20080401 |
| Modification of vimentin: a general mechanism of nonenzymatic glycation in human skin. | Annals of the New York Academy of Sciences 20080401 |
| Bisphosphonates alter trabecular bone collagen cross-linking and isomerization in beagle dog vertebra. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20080301 |
| Serum pentosidine levels are positively associated with the presence of vertebral fractures in postmenopausal women with type 2 diabetes. | The Journal of clinical endocrinology and metabolism 20080301 |
| Bone degeneration and recovery after early and late bisphosphonate treatment of ovariectomized wistar rats assessed by in vivo micro-computed tomography. | Calcified tissue international 20080301 |
| [Assessment of bone quality. Effects of bisphosphonates, raloxifene, alfacalcidol, and menatetrenone on bone quality: collagen cross-links, mineralization, and microdamage]. | Clinical calcium 20080301 |
| Soluble Receptor for advanced glycation end products (RAGE) is a prognostic factor for heart failure. | Journal of cardiac failure 20080301 |
| Renoprotective effects of the AGE-inhibitor pyridoxamine in experimental chronic allograft nephropathy in rats. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20080201 |
| Glycated fetal calf serum affects the viability of an insulin-secreting cell line in vitro. | Metabolism: clinical and experimental 20080201 |
| Advanced glycation end-product pentosidine accumulates in various tissues of rats with high fructose intake. | Physiological research 20080101 |
| Etanercept reduces the oxidative stress marker levels in patients with rheumatoid arthritis. | Rheumatology international 20080101 |
| Oxidative stress and asymmetric dimethylarginine is independently associated with carotid intima media thickness in peritoneal dialysis patients. | American journal of nephrology 20080101 |
| Measurements of mobile and bound water by nuclear magnetic resonance correlate with mechanical properties of bone. | Bone 20080101 |
| An in vitro model to test the contribution of advanced glycation end products to bone biomechanical properties. | Bone 20080101 |
| Nonenzymatic collagen cross-links induced by glycoxidation (pentosidine) predicts vertebral fractures. | Journal of bone and mineral metabolism 20080101 |
| A proposed new classification for diabetic retinopathy: the concept of primary and secondary vitreopathy. | Indian journal of ophthalmology 20080101 |
| Interleukin-6 is a better predictor of mortality as compared to C-reactive protein, homocysteine, pentosidine and advanced oxidation protein products in hemodialysis patients. | Blood purification 20080101 |
| Biochemical study of collagen and its crosslinks in the anterior cruciate ligament and the tissues used as a graft for reconstruction of the anterior cruciate ligament. | Connective tissue research 20080101 |
| Reduction of oxidative stress marker levels by anti-TNF-alpha antibody, infliximab, in patients with rheumatoid arthritis. | Clinical and experimental rheumatology 20080101 |
| UV-A-induced structural and functional changes in human lens deamidated alphaB-crystallin. | Molecular vision 20080101 |
| AGEs and glucose levels modulate type I and III procollagen mRNA synthesis in dermal fibroblasts cells culture. | Experimental diabetes research 20080101 |
| Cardiac troponin T and advanced glycation end-products in hemodialysis patients. | American journal of nephrology 20080101 |
| Serum levels of the advanced glycation end products Nepsilon-carboxymethyllysine and pentosidine are not influenced by treatment with the angiotensin receptor II type 1 blocker irbesartan in patients with type 2 diabetic nephropathy and hypertension. | Nephron. Clinical practice 20080101 |
| Collagen in its fibrillar state is protected from glycation. | The international journal of biochemistry & cell biology 20080101 |
| Role of advanced glycation end products in diabetic neuropathy. | Current pharmaceutical design 20080101 |
| PPARgamma Agonists: Potential as Therapeutics for Neovascular Retinopathies. | PPAR research 20080101 |
| An in vitro assay of collagen fiber alignment by acupuncture needle rotation. | Biomedical engineering online 20080101 |
| Reduction of plasma asymmetric dimethylarginine in obese patients with chronic kidney disease after three years of a low-protein diet supplemented with keto-amino acids: a randomized controlled trial. | Wiener klinische Wochenschrift 20080101 |
| The clinical relevance of assessing advanced glycation endproducts accumulation in diabetes. | Cardiovascular diabetology 20080101 |
| Immunochemical detection of glycated lens crystallins and their circulating autoantibodies in human serum during aging. | Molecular vision 20080101 |
| Inhibitory effects of ethyl acetate extract of Teucrium polium on in vitro protein glycoxidation. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20071201 |
| Thiazolidinediones provide better renoprotection than insulin in an obese, hypertensive type II diabetic rat model. | Kidney international 20071201 |
| Collagen, cross-linking, and advanced glycation end products in aging human skeletal muscle. | Journal of applied physiology (Bethesda, Md. : 1985) 20071201 |
| Endothelial dysfunction in diabetes mellitus. | Vascular health and risk management 20071201 |
| Oxidative stress and cellular stress response in diabetic nephropathy. | Cell stress & chaperones 20071201 |
| [Assessment of bone quality with metabolic bone markers]. | Nihon rinsho. Japanese journal of clinical medicine 20071128 |
| Relationship between proinsulin-to-insulin ratio and advanced glycation endproducts in Japanese type 2 diabetic subjects. | Diabetes research and clinical practice 20071101 |
| Confocal Raman microscopy can quantify advanced glycation end product (AGE) modifications in Bruch's membrane leading to accurate, nondestructive prediction of ocular aging. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20071101 |
| Advanced glycation end products and the absence of premature atherosclerosis in glycogen storage disease Ia. | Journal of inherited metabolic disease 20071101 |
| Dehydroepiandrosterone administration counteracts oxidative imbalance and advanced glycation end product formation in type 2 diabetic patients. | Diabetes care 20071101 |
| Contents of pentosidine in the tissue of the intervertebral disc as an indicator of the human age. | Soudni lekarstvi 20071001 |
| Achilles tendinosis: changes in biochemical composition and collagen turnover rate. | The American journal of sports medicine 20070901 |
| Angiotensin II receptor blocker inhibits abnormal accumulation of advanced glycation end products and retinal damage in a rat model of type 2 diabetes. | Experimental eye research 20070901 |
| [Is the serum concentration of pentosidine a predictor of cardiovascular events in patients with type 2 diabetes and kidney disease?]. | Deutsche medizinische Wochenschrift (1946) 20070901 |
| Role of N-(carboxymethyl)lysine in the development of ischemic heart disease in type 2 diabetes mellitus. | Journal of clinical biochemistry and nutrition 20070901 |
| Nonenzymatic antioxidative and antiglycative effects of oleanolic acid and ursolic acid. | Journal of agricultural and food chemistry 20070822 |
| Aspirin inhibits the formation of pentosidine, a cross-linking advanced glycation end product, in collagen. | Diabetes research and clinical practice 20070801 |
| Serum vitamin E and oxidative protein modification in hemodialysis: a randomized clinical trial. | American journal of kidney diseases : the official journal of the National Kidney Foundation 20070801 |
| Effect of the super-flux cellulose triacetate dialyser membrane on the removal of non-protein-bound and protein-bound uraemic solutes. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070701 |
| Age-related factors affecting the postyield energy dissipation of human cortical bone. | Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20070501 |
| Methylglyoxal inhibits glycation-mediated loss in chaperone function and synthesis of pentosidine in alpha-crystallin. | Experimental eye research 20070501 |
| Treatment with anti-TNF-alpha antibody infliximab reduces serum IL-15 levels in patients with rheumatoid arthritis. | Clinical rheumatology 20070401 |
| Flavonoids inhibit the formation of the cross-linking AGE pentosidine in collagen incubated with glucose, according to their structure. | European journal of nutrition 20070401 |
| Forty years of furosine - forty years of using Maillard reaction products as indicators of the nutritional quality of foods. | Molecular nutrition & food research 20070401 |
| High serum level of pentosidine, an advanced glycation end product (AGE), is a risk factor of patients with heart failure. | Journal of cardiac failure 20070401 |
| Advanced glycation end products and antioxidant status in type 2 diabetic patients with and without peripheral artery disease. | Diabetes care 20070301 |
| Non-enzymatic glycation of bone collagen modifies osteoclastic activity and differentiation. | The Journal of biological chemistry 20070223 |
| Urinary pentosidine does not predict cartilage loss among subjects with symptomatic knee OA: the BOKS Study. | Osteoarthritis and cartilage 20070101 |
| Advanced glycation end product deposits in climatic droplet keratopathy. | The British journal of ophthalmology 20070101 |
| Endogenous secretory receptor for advanced glycation endproducts levels are correlated with serum pentosidine and CML in patients with type 1 diabetes. | Arteriosclerosis, thrombosis, and vascular biology 20070101 |
| Indoxyl sulfate and atherosclerotic risk factors in hemodialysis patients. | American journal of nephrology 20070101 |
| Advanced glycation end-product pentosidine is not a relevant marker of disease activity in patients with rheumatoid arthritis. | Physiological research 20070101 |
| Carbonyl stress reduction in peritoneal dialysis fluid: development of a novel high-affinity adsorption bead. | Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20070101 |
| The road to advanced glycation end products: a mechanistic perspective. | Current medicinal chemistry 20070101 |
| Methotrexate reduces the levels of pentosidine and 8-hydroxy-deoxy guanosine in patients with rheumatoid arthritis. | Modern rheumatology 20070101 |
| Immunohistochemical study of N-epsilon-carboxymethyl lysine (CML) in human brain: relation to vascular dementia. | BMC neurology 20070101 |
| [Inhibition of advanced glycation by flavonoids. A nutritional implication for preventing diabetes complications?]. | Journal de la Societe de biologie 20070101 |
| [The metabolic, nutritional and toxicological consequences of ingested dietary Maillard reaction products: a literature review]. | Journal de la Societe de biologie 20070101 |
| Methodology and applications of disease biomarker identification in human serum. | Biomarker insights 20070101 |
| Endogenous Secretory RAGE as a Novel Biomarker for Metabolic Syndrome and Cardiovascular Diseases. | Biomarker insights 20070101 |
| Effects of valsartan therapy on protein glycoxidation. | Metabolism: clinical and experimental 20061201 |
| [Elevated plasma concentration of homocysteine, low level of vitamin B6, pyridoxal, and vitamin D insufficiency in patients with hip fracture: a possible explanation for detrimental cross-link pattern in bone collagen]. | Clinical calcium 20061201 |
| Correlation between pentosidine and endothelin-1 in subjects undergoing chronic hemodialysis. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20061201 |
| Plasma pentosidine and total homocysteine levels in relation to change in common carotid intima-media area in the first year of dialysis therapy. | Clinical nephrology 20061201 |
| Contribution of the advanced glycation end product pentosidine and of maturation of type I collagen to compressive biomechanical properties of human lumbar vertebrae. | Bone 20061101 |
| Evaluation of a urinary multi-parameter biomarker set for oxidative stress in children, adolescents and young adults. | Free radical research 20061101 |
| Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients. | Vascular medicine (London, England) 20061101 |
| Role of collagen enzymatic and glycation induced cross-links as a determinant of bone quality in spontaneously diabetic WBN/Kob rats. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20061001 |
| Age-related accumulation of pentosidine in aggrecan and collagen from normal and degenerate human intervertebral discs. | The Biochemical journal 20061001 |
| Advanced glycation end-products and methionine sulphoxide in skin collagen of patients with type 1 diabetes. | Diabetologia 20061001 |
| Degree of mineralization-related collagen crosslinking in the femoral neck cancellous bone in cases of hip fracture and controls. | Calcified tissue international 20060901 |
| Oxidatively modified autoantigens in autoimmune diseases. | Free radical biology & medicine 20060815 |
| Inhibition of advanced glycation end product formation on collagen by rutin and its metabolites. | The Journal of nutritional biochemistry 20060801 |
| Pentosidine in osteoarthritis: HPLC determination in body fluids and in tissues. | Rheumatology international 20060801 |
| The clinical significance of serum and urinary neopterin levels in several renal diseases. | Journal of Korean medical science 20060801 |
| [Oxidative stress marker]. | Nihon rinsho. Japanese journal of clinical medicine 20060801 |
| Oxidative stress, advanced glycation end product, and coronary artery calcification in hemodialysis patients. | Kidney international 20060701 |
| Effect of high-dose thiamine and pyridoxine on advanced glycation end products and other oxidative stress markers in hemodialysis patients: a randomized placebo-controlled study. | Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 20060401 |
| Postprandial mononuclear NF-kappaB activation is independent of the AGE-content of a single meal. | Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20060401 |
| Extracellular post-translational modifications of collagen are major determinants of biomechanical properties of fetal bovine cortical bone. | Bone 20060301 |
| A severe diabetic nephropathy model with early development of nodule-like lesions induced by megsin overexpression in RAGE/iNOS transgenic mice. | Diabetes 20060201 |
| Immunohistochemical localization of advanced glycation end products in pinguecula. | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20060101 |
| Activation of receptor for advanced glycation end products in osteoarthritis leads to increased stimulation of chondrocytes and synoviocytes. | Arthritis and rheumatism 20060101 |
| Plantar skin in type II diabetes: an investigation of protein glycation and biomechanical properties of plantar epidermis. | European journal of dermatology : EJD 20060101 |
| Spectroscopic and biochemical correlations during the course of human lens aging. | BMC ophthalmology 20060101 |
| The influence of gender, weight, height and BMI on pentosidine concentrations in plasma of hemodialyzed patients. | Journal of nephrology 20060101 |
| Reductions in degree of mineralization and enzymatic collagen cross-links and increases in glycation-induced pentosidine in the femoral neck cortex in cases of femoral neck fracture. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20060101 |
| Prevention and repair of protein damage by the Maillard reaction in vivo. | Rejuvenation research 20060101 |
| Role of vitamin E-coated membrane in reducing advanced glycation end products in hemodialysis patients: a pilot study. | Blood purification 20060101 |
| Oxidative stress in hepatitis C infected end-stage renal disease subjects. | BMC infectious diseases 20060101 |
| Pyridoxamine inhibits maillard reactions in diabetic rat lenses. | Ophthalmic research 20060101 |
| Transition of healthy to diseased synovial tissue in rheumatoid arthritis is associated with gain of mesenchymal/fibrotic characteristics. | Arthritis research & therapy 20060101 |
| The advanced glycation end product pentosidine correlates to IL-6 and other relevant inflammatory markers in rheumatoid arthritis. | Rheumatology international 20051201 |
| Levels of pentosidine in the vitreous of eyes with proliferative diabetic retinopathy, proliferative vitreoretinopathy and retinal detachment. | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20051201 |
| Trabecular microfracture and the influence of pyridinium and non-enzymatic glycation-mediated collagen cross-links. | Bone 20051201 |
| In a type 2 diabetic nephropathy rat model, the improvement of obesity by a low calorie diet reduces oxidative/carbonyl stress and prevents diabetic nephropathy. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20051201 |
| Renoprotective properties of angiotensin receptor blockers beyond blood pressure lowering. | Journal of the American Society of Nephrology : JASN 20051201 |
| Skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation end products, predicts mortality in hemodialysis patients. | Journal of the American Society of Nephrology : JASN 20051201 |
| Pentosidine and its deposition in renal tissue in renal transplantation. | Transplantation proceedings 20051201 |
| Oxidation and carboxy methyl lysine-modification of albumin: possible involvement in the progression of oxidative stress in hemodialysis patients. | Hypertension research : official journal of the Japanese Society of Hypertension 20051201 |
| Cardiovascular disease in diabetic nephropathy patients: cell adhesion molecules as potential markers? | Vascular health and risk management 20051201 |
| Advanced glycoxidation end products in chronic diseases-clinical chemistry and genetic background. | Mutation research 20051111 |
| Renal accumulation of pentosidine in non-diabetic proteinuria-induced renal damage in rats. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20051001 |
| Decreased levels of advanced glycation end-products in patients with Gilbert syndrome. | Cellular and molecular biology (Noisy-le-Grand, France) 20050930 |
| Pyridoxamine improves functional, structural, and biochemical alterations of peritoneal membranes in uremic peritoneal dialysis rats. | Kidney international 20050901 |
| Functional adaptation through changes in regional biochemical characteristics during maturation of equine superficial digital flexor tendons. | American journal of veterinary research 20050901 |
| Principal component analysis of some oxidative stress parameters and their relationships in hemodialytic and transplanted patients. | Clinica chimica acta; international journal of clinical chemistry 20050801 |
| Modulation of soluble receptor for advanced glycation end products by angiotensin-converting enzyme-1 inhibition in diabetic nephropathy. | Journal of the American Society of Nephrology : JASN 20050801 |
| Degradation products of proteins damaged by glycation, oxidation and nitration in clinical type 1 diabetes. | Diabetologia 20050801 |
| Renal accumulation and clearance of advanced glycation end-products in type 2 diabetic nephropathy: effect of angiotensin-converting enzyme and vasopeptidase inhibition. | Diabetologia 20050801 |
| Advanced glycation end products are associated with pulse pressure in type 1 diabetes: the EURODIAB Prospective Complications Study. | Hypertension (Dallas, Tex. : 1979) 20050701 |
| Evaluation of advanced glycation end products and carbonyl compounds in patients with different conditions of oxidative stress. | Molecular nutrition & food research 20050701 |
| Increased pentosidine, an advanced glycation end product, in serum and synovial fluid from patients with knee osteoarthritis and its relation with cartilage oligomeric matrix protein. | Annals of the rheumatic diseases 20050601 |
| Enhanced RAGE-mediated NFkappaB stimulation in inflamed hemodialysis patients. | Atherosclerosis 20050601 |
| [Measurement of plasma pentosidine and the clinical significance in diagnosis of diabetic nephropathies]. | Nihon rinsho. Japanese journal of clinical medicine 20050601 |
| Evaluation of glyoxal and methylglyoxal levels in uremic patients under peritoneal dialysis. | Annals of the New York Academy of Sciences 20050601 |
| Simple noninvasive measurement of skin autofluorescence. | Annals of the New York Academy of Sciences 20050601 |
| Studies on absorption and elimination of dietary maillard reaction products. | Annals of the New York Academy of Sciences 20050601 |
| Dietary bread crust advanced glycation end products bind to the receptor for AGEs in HEK-293 kidney cells but are rapidly excreted after oral administration to healthy and subtotally nephrectomized rats. | Annals of the New York Academy of Sciences 20050601 |
| Low-molecular weight advanced glycation end products: markers of tissue AGE accumulation and more? | Annals of the New York Academy of Sciences 20050601 |
| Advanced glycation end products and bone loss during aging. | Annals of the New York Academy of Sciences 20050601 |
| Advanced glycation end product free adducts are cleared by dialysis. | Annals of the New York Academy of Sciences 20050601 |
| From molecular footprints of disease to new therapeutic interventions in diabetic nephropathy. | Annals of the New York Academy of Sciences 20050601 |
| Central role of PKCdelta in glycoxidation-dependent apoptosis of human neurons. | Free radical biology & medicine 20050401 |
| Antioxidant status in J774A.1 macrophage cell line during chronic exposure to glycated serum. | Biochemistry and cell biology = Biochimie et biologie cellulaire 20050401 |
| Pentosidine plasma levels and relation with metabolic control in diabetic patients. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20050401 |
| High serum pentosidine concentrations are associated with increased arterial stiffness and thickness in patients with type 2 diabetes. | Metabolism: clinical and experimental 20050301 |
| Enzyme activity and AGE formation in a model of AST glycoxidation by D-fructose in vitro. | Acta pharmaceutica (Zagreb, Croatia) 20050301 |
| Glycoxidation and inflammatory markers in patients on treatment with PMMA-based protein-leaking dialyzers. | Kidney international 20050201 |
| Reversal by aminoguanidine of the age-related increase in glycoxidation and lipoxidation in the cardiovascular system of Fischer 344 rats. | Biochemical pharmacology 20050101 |
| Weight reduction is not a major reason for improvement in rheumatoid arthritis from lacto-vegetarian, vegan or Mediterranean diets. | Nutrition journal 20050101 |
| Ultrapure dialysate reduces plasma levels of beta2-microglobulin and pentosidine in hemodialysis patients. | Blood purification 20050101 |
| Circulating levels of nitrated apolipoprotein A-I are increased in type 2 diabetic patients. | Clinical chemistry and laboratory medicine 20050101 |
| Advanced glycoxidation end products in patients with multiple sclerosis. | Prague medical report 20050101 |
| The influence of hepatitis C and iron replacement therapy on plasma pentosidine levels in haemodialysis patients. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20041201 |
| Relationship between blood levels of N-carboxymethyl-lysine and pentosidine and the severity of microangiopathy in type 2 diabetes. | Endocrine journal 20041201 |
| A sensitive and specific HPLC method for the determination of total pentosidine concentration in plasma. | Journal of biochemical and biophysical methods 20041130 |
| The effects of valsartan on the accumulation of circulating and renal advanced glycation end products in experimental diabetes. | Kidney international. Supplement 20041101 |
| [Urinary pentosidine]. | Nihon rinsho. Japanese journal of clinical medicine 20041101 |
| [Activation of receptor for advanced glycation end products: a mechanism for monocyte-mediated inflammation in chronic renal failure]. | Zhonghua yi xue za zhi 20041002 |
| Thrombotic events and markers of oxidation and inflammation in hemodialysis. | Hemodialysis international. International Symposium on Home Hemodialysis 20041001 |
| Nepsilon-(Carboxymethyl)lysine and 3-DG-imidazolone are major AGE structures in protein modification by 3-deoxyglucosone. | Journal of biochemistry 20040901 |
| Improvement of the quality of diabetes control and decrease in the concentrations of AGE-products in patients with type 1 and insulin-treated type 2 diabetes mellitus: results from a 10 year-prospective, population-based survey on the quality of diabetes care in Germany (JEVIN). | European journal of medical research 20040831 |
| Dissociation between urinary pyrraline and pentosidine concentrations in diabetic patients with advanced nephropathy. | The Journal of laboratory and clinical medicine 20040801 |
| Normalization of oxidative stress parameters after kidney transplant is secondary to full recovery of renal function. | Clinical nephrology 20040801 |
| Potential cardiovascular risk factors in chronic kidney disease: AGEs, total homocysteine and metabolites, and the C-reactive protein. | Kidney international 20040701 |
| Enhanced expression of receptor for advanced glycation end products in chronic kidney disease. | Journal of the American Society of Nephrology : JASN 20040701 |
| Simple non-invasive assessment of advanced glycation endproduct accumulation. | Diabetologia 20040701 |
| Concentrations of pentosidine, an advanced glycation end-product, in umbilical cord blood. | Free radical research 20040701 |
| Biochemical and spectrophotometric significance of advanced oxidized protein products. | Biochimica et biophysica acta 20040628 |
| Ultrapure dialysate decreases plasma pentosidine, a marker of 'carbonyl stress'. | American journal of kidney diseases : the official journal of the National Kidney Foundation 20040601 |
| Unexpected elevation of pentosidine formation in collagen incubated with glucose by low concentrations of the AGE-inhibitor aminoguanidine. | Diabetologia 20040501 |
| Hyaluronic acid levels may have predictive value for the progression of knee osteoarthritis. | Osteoarthritis and cartilage 20040401 |
| Increased production of urea hydrogen peroxide from Maillard reaction and a UHP-Fenton pathway related to glycoxidation damage in chronic renal failure. | Journal of the American Society of Nephrology : JASN 20040401 |
| Association between pentosidine and arteriosclerosis in patients receiving hemodialysis. | Clinical and experimental nephrology 20040301 |
| Influence of hemodialysis membrane permeability on serum levels of advanced glycation end products (AGEs) and homocysteine metabolites. | Clinical nephrology 20040301 |
| Diabetes increases formation of advanced glycation end products on Sarco(endo)plasmic reticulum Ca2+-ATPase. | Diabetes 20040201 |
| Advanced glycation end product ligands for the receptor for advanced glycation end products: biochemical characterization and formation kinetics. | Analytical biochemistry 20040101 |
| Advanced glycation end products and oxidative stress are increased in chronic allograft nephropathy. | American journal of kidney diseases : the official journal of the National Kidney Foundation 20040101 |
| Tomato paste fraction inhibiting the formation of advanced glycation end-products. | Bioscience, biotechnology, and biochemistry 20040101 |
| Calorie restricted diet and urinary pentosidine in patients with rheumatoid arthritis. | Journal of physiological anthropology and applied human science 20040101 |
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