200,000+ products from a single source!
sales@angenechem.com
124351-85-5 | Phosphonic acid, P,P'-[(cycloheptylamino)methylene]bis-
CAS No: 124351-85-5 Catalog No: AG000LXG MDL No:
Product Description
Catalog Number:
AG000LXG
Chemical Name:
Phosphonic acid, P,P'-[(cycloheptylamino)methylene]bis-
CAS Number:
124351-85-5
Molecular Formula:
C8H19NO6P2
Molecular Weight:
287.1871
IUPAC Name:
[(cycloheptylamino)-phosphonomethyl]phosphonic acid
InChI:
InChI=1S/C8H19NO6P2/c10-16(11,12)8(17(13,14)15)9-7-5-3-1-2-4-6-7/h7-9H,1-6H2,(H2,10,11,12)(H2,13,14,15)
InChI Key:
LWRDQHOZTAOILO-UHFFFAOYSA-N
SMILES:
OP(=O)(C(P(=O)(O)O)NC1CCCCCC1)O
UNII:
G5C4M8847E
NSC Number:
723271
Properties
Complexity:
307
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
287.069g/mol
Formal Charge:
0
Heavy Atom Count:
17
Hydrogen Bond Acceptor Count:
7
Hydrogen Bond Donor Count:
5
Isotope Atom Count:
0
Molecular Weight:
287.189g/mol
Monoisotopic Mass:
287.069g/mol
Rotatable Bond Count:
4
Topological Polar Surface Area:
127A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-3.5
Literature
| Title | Journal |
|---|---|
| The bisphosphonate incadronate inhibits intraperitoneal dissemination in an in vivo pancreatic cancer model. | Oncology reports 20120701 |
| [Long-term and high-dose bisphosphonate administration causes no bone over-mineralization]. | Zhonghua yi xue za zhi 20091117 |
| Ibadronate may prevent colorectal carcinogenesis in mice with ulcerative colitis. | Anticancer research 20091101 |
| Collagen maturity, glycation induced-pentosidine, and mineralization are increased following 3-year treatment with incadronate in dogs. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20080901 |
| Lung and bone metastases from renal cell carcinoma responsive to bisphosphonates: a case report. | International journal of urology : official journal of the Japanese Urological Association 20080601 |
| Sugar synthesis from a gas-phase formose reaction. | Astrobiology 20070601 |
| Clinical evaluation of incadronate in korean patients with malignancy-associated hypercalcemia: An open-label, multicenter study. | Current therapeutic research, clinical and experimental 20070501 |
| Bisphosphonate incadronate inhibits growth of human T-cell leukaemia virus type I-infected T-cell lines and primary adult T-cell leukaemia cells by interfering with the mevalonate pathway. | British journal of haematology 20070201 |
| Inhibition of bone resorption in cultures of mouse calvariae by apicularen A. | Planta medica 20070201 |
| Incadronate induces cell detachment and apoptosis in prostatic PC-3 cells. | Anticancer research 20070101 |
| Isoprenoid biosynthesis as a drug target: bisphosphonate inhibition of Escherichia coli K12 growth and synergistic effects of fosmidomycin. | Journal of medicinal chemistry 20061214 |
| Hyperbaric oxygen in addition to antibiotic therapy is effective for bisphosphonate-induced osteonecrosis of the jaw in a patient with multiple myeloma. | International journal of hematology 20061101 |
| Incadronate inhibits aminopeptidase N expression in prostatic PC-3 cells. | Cancer letters 20060618 |
| Inhibition of caveolin-1 expression by incadronate in PC-3 prostate cells. | Anticancer research 20060101 |
| Effect of incadronate on proliferation of mesenchymal tumor cells with or without activated Ras mutation. | Journal of experimental & clinical cancer research : CR 20051201 |
| Nitrogen-containing bisphosphonate incadronate augments the inhibitory effect of farnesyl transferase inhibitor tipifarnib on the growth of fresh and cloned myeloma cells in vitro. | Leukemia & lymphoma 20051101 |
| Combination therapy with thalidomide, incadronate, and dexamethasone for relapsed or refractory multiple myeloma. | International journal of hematology 20051001 |
| Bisphosphonate inhibitors of Toxoplasma gondi growth: in vitro, QSAR, and in vivo investigations. | Journal of medicinal chemistry 20050505 |
| Incadronate disodium inhibits joint destruction and periarticular bone loss only in the early phase of rat adjuvant-induced arthritis. | Journal of bone and mineral metabolism 20050101 |
| Effect of incadronate on corticosteroid-induced osteopenia in rats. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040901 |
| Alendronate inhibits urinary calcium microlith formation in a three-dimensional culture model. | Urological research 20040601 |
| Quantitative structure-activity relationships for gammadelta T cell activation by bisphosphonates. | Journal of medicinal chemistry 20040115 |
| Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo. | Journal of medicinal chemistry 20040101 |
| 3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates. | Journal of medicinal chemistry 20031120 |
| Nitrogen-containing bisphosphonates induce S-phase cell cycle arrest and apoptosis of myeloma cells by activating MAPK pathway and inhibiting mevalonate pathway. | Cellular signalling 20030701 |
| Nitrogen containing bisphosphonates induce apoptosis and inhibit the mevalonate pathway, impairing Ras membrane localization in prostate cancer cells. | The Journal of urology 20030701 |
| Antiinflammatory and chondroprotective effects of the aminobisphosphonate incadronate (YM175) in adjuvant induced arthritis. | The Journal of rheumatology 20030601 |
| [Changes of urinary deoxypyridinoline crosslink/creatinine in rats after ovariectomy and anti-osteoporotic intervention]. | Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20030601 |
| Incadronate amplifies prostaglandin F2 alpha-induced vascular endothelial growth factor synthesis in osteoblasts. Enhancement of MAPK activity. | The Journal of biological chemistry 20030523 |
| Hydronium (cycloheptylammonio)methylene-1,1-bisphosphonate (hydronium incadronate). | Acta crystallographica. Section C, Crystal structure communications 20030201 |
| Bisphosphonate therapy for hormone refractory prostate cancer with bone metastasis. | The Journal of urology 20030101 |
| Effects of bisphosphonate on bone reaction after placement of titanium implants in tibiae of ovariectomized rats. | The International journal of oral & maxillofacial implants 20030101 |
| Incadronate disodium inhibits advanced glycation end products-induced angiogenesis in vitro. | Biochemical and biophysical research communications 20020920 |
| Highly potent geminal bisphosphonates. From pamidronate disodium (Aredia) to zoledronic acid (Zometa). | Journal of medicinal chemistry 20020815 |
| Comparison of incadronate and alfacalcidol on increased bone turnover caused by ovariectomy in rats. | European journal of pharmacology 20020802 |
| An investigation of bone resorption and Dictyostelium discoideum growth inhibition by bisphosphonate drugs. | Journal of medicinal chemistry 20020704 |
| Incadronate and etidronate accelerate phosphate-primed mineralization of MC4 cells via ERK1/2-Cbfa1 signaling pathway in a Ras-independent manner: further involvement of mevalonate-pathway blockade for incadronate. | Japanese journal of pharmacology 20010501 |
| Long-term effect of incadronate disodium (YM-175) on fracture healing of femoral shaft in growing rats. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20010301 |
| A newly developed bisphosphonate, YM529, is a potent apoptosis inducer of human myeloma cells. | Leukemia research 20010101 |
| [A case of effective bisphosphonate therapy of sequential pamidronate and incadronate for bone metastases from breast cancer]. | Gan to kagaku ryoho. Cancer & chemotherapy 20000801 |
| [Breast cancer with osteoblastic bone metastasis treated successfully with bisphosphonate: a case report]. | Gan to kagaku ryoho. Cancer & chemotherapy 19991001 |
| The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway. | Cancer research 19981201 |
| Pharmacokinetics of incadronate, a new bisphosphonate, in healthy volunteers and patients with malignancy-associated hypercalcemia. | International journal of clinical pharmacology and therapeutics 19970601 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.