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123715-02-6 | L-Tyrosine, 2,6-dimethyl-
CAS No: 123715-02-6 Catalog No: AG000KZP MDL No:MFCD06659984
Product Description
Catalog Number:
AG000KZP
Chemical Name:
L-Tyrosine, 2,6-dimethyl-
CAS Number:
123715-02-6
Molecular Formula:
C11H15NO3
Molecular Weight:
209.2417
MDL Number:
MFCD06659984
IUPAC Name:
(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoic acid
InChI:
InChI=1S/C11H15NO3/c1-6-3-8(13)4-7(2)9(6)5-10(12)11(14)15/h3-4,10,13H,5,12H2,1-2H3,(H,14,15)/t10-/m0/s1
InChI Key:
LSNDLIKCFHLFKO-JTQLQIEISA-N
SMILES:
OC(=O)[C@H](Cc1c(C)cc(cc1C)O)N
Properties
Complexity:
220
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
1
Defined Bond Stereocenter Count:
0
Exact Mass:
209.105g/mol
Formal Charge:
0
Heavy Atom Count:
15
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
209.245g/mol
Monoisotopic Mass:
209.105g/mol
Rotatable Bond Count:
3
Topological Polar Surface Area:
83.6A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-1
Literature
| Title | Journal |
|---|---|
| Characterization of antinociceptive potency of endomorphin-2 derivatives with unnatural amino acids in rats. | Acta physiologica Hungarica 20120901 |
| Bifunctional μ/δ opioid peptides: variation of the type and length of the linker connecting the two components. | Chemical biology & drug design 20120201 |
| In vivo antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist-neurokinin 1 receptor antagonist chimera. | Molecular brain 20120101 |
| Lipo-endomorphin-1 derivatives with systemic activity against neuropathic pain without producing constipation. | PloS one 20120101 |
| Effect of 2',6'-dimethyl-L-tyrosine (Dmt) on pharmacological activity of cyclic endomorphin-2 and morphiceptin analogs. | Bioorganic & medicinal chemistry 20111201 |
| Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies. | Journal of medicinal chemistry 20110414 |
| Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compounds. | Bioorganic & medicinal chemistry 20100815 |
| N-methylated cyclic enkephalin analogues retain high opioid receptor binding affinity. | Chemical biology & drug design 20100201 |
| Delta opioid receptor on equine sperm cells: subcellular localization and involvement in sperm motility analyzed by computer assisted sperm analyzer (CASA). | Reproductive biology and endocrinology : RB&E 20100101 |
| Cyclic opioid peptide agonists and antagonists obtained via ring-closing metathesis. | Chemical biology & drug design 20091001 |
| [Overview in 45 years of studies on peptide chemistry]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20091001 |
| Biological activity of endomorphin and [Dmt1]endomorphin analogs with six-membered proline surrogates in position 2. | Bioorganic & medicinal chemistry 20090601 |
| Novel opioid peptide derived antagonists containing (2S)-2-methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid [(2S)-Mdcp]. | Journal of medicinal chemistry 20080925 |
| Conformation-activity relationships of cyclo-constrained micro/delta opioid agonists derived from the N-terminal tetrapeptide segment of dermorphin/deltorphin. | Journal of peptide science : an official publication of the European Peptide Society 20080801 |
| Synthesis and in vitro evaluation of a library of modified endomorphin 1 peptides. | Bioorganic & medicinal chemistry 20080601 |
| Targeting mitochondria. | Accounts of chemical research 20080101 |
| Design and synthesis of opioidmimetics containing 2',6'-dimethyl-L-tyrosine and a pyrazinone-ring platform. | Bioorganic & medicinal chemistry letters 20071101 |
| [N-allyl-Dmt1]-endomorphins are micro-opioid receptor antagonists lacking inverse agonist properties. | The Journal of pharmacology and experimental therapeutics 20071001 |
| Novel diastereomeric opioid tetrapeptides exhibit differing pharmacological activity profiles. | Brain research bulletin 20070914 |
| Bioactivity of new mu and delta opioid peptides. | Medicinal chemistry (Shariqah (United Arab Emirates)) 20070901 |
| Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/delta-antagonist and dual mu-agonist/delta-agonist opioid ligands. | Journal of medicinal chemistry 20070614 |
| Comparison of the in vitro apparent permeability and stability of opioid mimetic compounds with that of the native peptide. | Bioorganic & medicinal chemistry letters 20070401 |
| Synthesis and characterization of potent and selective mu-opioid receptor antagonists, [Dmt(1), D-2-Nal(4)]endomorphin-1 (Antanal-1) and [Dmt(1), D-2-Nal(4)]endomorphin-2 (Antanal-2). | Journal of medicinal chemistry 20070208 |
| Replacement of the N-terminal tyrosine residue in opioid peptides with 3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid (Dcp) results in novel opioid antagonists. | Journal of medicinal chemistry 20060824 |
| New 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligands. | Journal of medicinal chemistry 20060629 |
| Novel 99mTc-labeled neurotensin analogues with optimized biodistribution properties. | Journal of medicinal chemistry 20060309 |
| Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell lines. | Biochemical pharmacology 20051205 |
| Opioid peptide-derived analgesics. | The AAPS journal 20050901 |
| Type and location of fluorescent probes incorporated into the potent mu-opioid peptide [Dmt]DALDA affect potency, receptor selectivity and intrinsic efficacy. | The journal of peptide research : official journal of the American Peptide Society 20050601 |
| A new structural motif for mu-opioid antagonists. | Journal of medicinal chemistry 20050519 |
| Studies on the structure-activity relationship of 2',6'-dimethyl-l-tyrosine (Dmt) derivatives: bioactivity profile of H-Dmt-NH-CH(3). | Bioorganic & medicinal chemistry letters 20050201 |
| Fluorescent dyes alter intracellular targeting and function of cell-penetrating tetrapeptides. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050101 |
| Opioid receptor binding characteristics and structure-activity studies of novel tetrapeptides in the TIPP (Tyr-Tic-Phe-Phe) series. | Neuro-Signals 20050101 |
| Tolerance develops in spinal cord, but not in brain with chronic [Dmt1]DALDA treatment. | British journal of pharmacology 20041201 |
| Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury. | The Journal of biological chemistry 20040813 |
| Quantitative analysis of [Dmt(1)]DALDA in ovine plasma by capillary liquid chromatography-nanospray ion-trap mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040415 |
| Novel 2',6'-dimethyl-L-tyrosine-containing pyrazinone opioid mimetic mu-agonists with potent antinociceptive activity in mice. | The Journal of pharmacology and experimental therapeutics 20040401 |
| 2',6'-dimethylphenylalanine (Dmp) can mimic the N-terminal Tyr in opioid peptides. | Biological & pharmaceutical bulletin 20040201 |
| Dansylated analogues of the opioid peptide [Dmt1]DALDA: in vitro activity profiles and fluorescence parameters. | Acta biochimica Polonica 20040101 |
| Comparison of [Dmt1]DALDA and DAMGO in binding and G protein activation at mu, delta, and kappa opioid receptors. | The Journal of pharmacology and experimental therapeutics 20031201 |
| Characterization of the binding of [3H][Dmt1]H-Dmt-D-Arg-Phe-Lys-NH2, a highly potent opioid peptide. | The Journal of pharmacology and experimental therapeutics 20030801 |
| Highly potent fluorescent analogues of the opioid peptide [Dmt1] DALDA. | Peptides 20030801 |
| Endogenous opioid peptides contribute to antinociceptive potency of intrathecal [Dmt1]DALDA. | The Journal of pharmacology and experimental therapeutics 20030501 |
| Structural studies of [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues: enhanced activity and cis orientation of the Dmt-Pro amide bond. | Bioorganic & medicinal chemistry 20030501 |
| 2,6-Dimethyltyrosine analogues of a stereodiversified ligand library: highly potent, selective, non-peptidic mu opioid receptor agonists. | Journal of medicinal chemistry 20030227 |
| Transcellular transport of a highly polar 3+ net charge opioid tetrapeptide. | The Journal of pharmacology and experimental therapeutics 20030101 |
| Quantification of [Dmt1]DALDA in ovine plasma by on-line liquid chromatography/quadrupole time-of-flight mass spectrometry. | Rapid communications in mass spectrometry : RCM 20030101 |
| Dmt and opioid peptides: a potent alliance. | Biopolymers 20030101 |
| [2',6'-Dimethyltyrosine]dynorphin A(1-11)-NH2 analogues lacking an N-terminal amino group: potent and selective kappa opioid antagonists. | Journal of medicinal chemistry 20010913 |
| Novel C-terminus modifications of the Dmt-Tic motif: a new class of dipeptide analogues showing altered pharmacological profiles toward the opioid receptors. | Journal of medicinal chemistry 20010719 |
| Probing the shape of a hydrophobic pocket in the active site of delta-opioid antagonists. | Journal of peptide science : an official publication of the European Peptide Society 20010701 |
| Antinociceptive and respiratory effects of intrathecal H-Tyr-D-Arg-Phe-Lys-NH2 (DALDA) and [Dmt1] DALDA. | The Journal of pharmacology and experimental therapeutics 20010401 |
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