200,000+ products from a single source!
sales@angenechem.com
123690-78-8 | Phosphinic acid, P-(3-aminopropyl)-P-butyl-
CAS No: 123690-78-8 Catalog No: AG000KYF MDL No:
Product Description
Catalog Number:
AG000KYF
Chemical Name:
Phosphinic acid, P-(3-aminopropyl)-P-butyl-
CAS Number:
123690-78-8
Molecular Formula:
C7H18NO2P
Molecular Weight:
179.1971
IUPAC Name:
3-aminopropyl(butyl)phosphinic acid
InChI:
InChI=1S/C7H18NO2P/c1-2-3-6-11(9,10)7-4-5-8/h2-8H2,1H3,(H,9,10)
InChI Key:
ONNMDRQRSGKZCN-UHFFFAOYSA-N
SMILES:
CCCCP(=O)(CCCN)O
UNII:
GBZ5UC0RME
Properties
Complexity:
138
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
179.108g/mol
Formal Charge:
0
Heavy Atom Count:
11
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
179.2g/mol
Monoisotopic Mass:
179.108g/mol
Rotatable Bond Count:
6
Topological Polar Surface Area:
63.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-2.7
Literature
| Title | Journal |
|---|---|
| Hippocampal synapsin isoform levels are linked to spatial memory enhancement by SGS742. | Hippocampus 20090801 |
| Novel, potent, and selective GABAC antagonists inhibit myopia development and facilitate learning and memory. | The Journal of pharmacology and experimental therapeutics 20090201 |
| Hippocampal levels of phosphorylated protein kinase A (phosphor-S96) are linked to spatial memory enhancement by SGS742. | Hippocampus 20090101 |
| Cognitive enhancement by SGS742 in OF1 mice is linked to specific hippocampal protein expression. | Journal of proteome research 20081201 |
| Novel gamma-aminobutyric acid rho1 receptor antagonists; synthesis, pharmacological activity and structure-activity relationships. | Journal of medicinal chemistry 20080710 |
| The cognitive enhancer SGS742 does not involve major known signaling cascades in OF1 mice. | Neurochemical research 20080701 |
| Hippocampal gene expression profiling reveals the possible involvement of Homer1 and GABA(B) receptors in scopolamine-induced amnesia. | Journal of neurochemistry 20070901 |
| Strain-dependent effects of SGS742 in the mouse. | Behavioural brain research 20070719 |
| Effects of GABAB receptor ligands in rodent tests of anxiety-like behavior. | Pharmacological reports : PR 20070101 |
| Antidepressant-like activity of CGP 36742 and CGP 51176, selective GABAB receptor antagonists, in rodents. | British journal of pharmacology 20061101 |
| Chronic intragastric administration of gamma-butyrolactone produces physical dependence in baboons. | Psychopharmacology 20061101 |
| Muscarinic suppression in stratum radiatum of CA1 shows dependence on presynaptic M1 receptors and is not dependent on effects at GABA(B) receptors. | Neurobiology of learning and memory 20060301 |
| GABAB receptor: a site of therapeutic benefit. | Current opinion in pharmacology 20060201 |
| Involvement of gamma-hydroxybutyrate (GHB) and GABA-B receptors in the acute behavioral effects of GHB in baboons. | Psychopharmacology 20050701 |
| GABAB receptor antagonist SGS742 improves spatial memory and reduces protein binding to the cAMP response element (CRE) in the hippocampus. | Neuropharmacology 20050601 |
| Spontaneous and precipitated withdrawal after chronic intragastric administration of gamma-hydroxybutyrate (GHB) in baboons. | Psychopharmacology 20050501 |
| Delta(9)-THC-induced cognitive deficits in mice are reversed by the GABA(A) antagonist bicuculline. | Psychopharmacology 20050301 |
| SGS-742 Novartis. | Current opinion in investigational drugs (London, England : 2000) 20050101 |
| SGS742: the first GABA(B) receptor antagonist in clinical trials. | Biochemical pharmacology 20041015 |
| GABA(B) receptor antagonist CGP-36742 enhances somatostatin release in the rat hippocampus in vivo and in vitro. | European journal of pharmacology 20031008 |
| Medicinal chemistry and molecular pharmacology of GABA(C) receptors. | Current topics in medicinal chemistry 20020801 |
| International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyric acid(B) receptors: structure and function. | Pharmacological reviews 20020601 |
| Early induction of secretoneurin expression following kainic acid administration at convulsant doses in the rat and gerbil hippocampus. | Hippocampus 20020101 |
| Blockade of gamma-aminobutyric acid receptors does not modify the inhibiton of ethanol intake induced by Hypericum perforatum in rats. | Alcohol and alcoholism (Oxford, Oxfordshire) 20020101 |
| AMPA and GABA(B) receptor antagonists and their interaction in rats with a genetic form of absence epilepsy. | European journal of pharmacology 20011102 |
| Potentiation of NMDA receptor function through somatostatin release: a possible mechanism for the cognition-enhancing activity of GABA(B) receptor antagonists. | Neuropharmacology 20010901 |
| GABA(B) receptors play a role in the development of tolerance to ethanol in mice. | Psychopharmacology 20010201 |
| The GABA(B) receptor antagonist CGP36742 attenuates the baclofen- and scopolamine-induced deficit in Morris water maze task in rats. | Brain research 19970822 |
| Phosphinic acid analogues of GABA. 2. Selective, orally active GABAB antagonists. | Journal of medicinal chemistry 19950818 |
| The actions of orally active GABAB receptor antagonists on GABAergic transmission in vivo and in vitro. | European journal of pharmacology 19930323 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.