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Home > Other Heterocycles > 1235-82-1
1235-82-1 | 1-Piperidinepropanol, α-bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-, hydrochloride (1:1)
CAS No: 1235-82-1 Catalog No: AG000KOS MDL No:MFCD00797516
Product Description
Catalog Number:
AG000KOS
Chemical Name:
1-Piperidinepropanol, α-bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-, hydrochloride (1:1)
CAS Number:
1235-82-1
Molecular Formula:
C21H30ClNO
Molecular Weight:
347.9220
MDL Number:
MFCD00797516
IUPAC Name:
1-(2-bicyclo[2.2.1]hept-5-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol;hydrochloride
InChI:
InChI=1S/C21H29NO.ClH/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17;/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2;1H
InChI Key:
RDNLAULGBSQZMP-UHFFFAOYSA-N
SMILES:
OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1.Cl
EC Number:
214-976-2
UNII:
K35N76CUHF
Properties
Complexity:
422
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
347.202g/mol
Formal Charge:
0
Heavy Atom Count:
24
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
347.927g/mol
Monoisotopic Mass:
347.202g/mol
Rotatable Bond Count:
5
Topological Polar Surface Area:
23.5A^2
Undefined Atom Stereocenter Count:
4
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Human electrophysiological correlates of learned irrelevance: effects of the muscarinic M1 antagonist biperiden. | The international journal of neuropsychopharmacology 20121101 |
| Biperiden (M₁ antagonist) impairs the expression of cocaine conditioned place preference but potentiates the expression of cocaine-induced behavioral sensitization. | Behavioural brain research 20120516 |
| The elevated T-maze task as an animal model to simultaneously investigate the effects of drugs on long-term memory and anxiety in mice. | Brain research bulletin 20120410 |
| Biperiden (an M1 antagonist) reduces memory consolidation of cocaine-conditioned place preference. | Neuroscience letters 20120404 |
| Novel PVC-membrane electrode for flow injection potentiometric determination of Biperiden in pharmaceutical preparations. | Talanta 20111215 |
| Assessment of rewarding and reinforcing properties of biperiden in conditioned place preference in rats. | Behavioural brain research 20111201 |
| Use of anticholinergic drugs and worsening of pemphigus foliaceus in a patient with bipolar disorder. | Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 20111201 |
| Biperiden-induced delirium in an adolescent patient. | Journal of child and adolescent psychopharmacology 20111001 |
| A comparison of scopolamine and biperiden as a rodent model for cholinergic cognitive impairment. | Psychopharmacology 20110601 |
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| Effects of discontinuation of long-term biperiden use on cognitive function and quality of life in schizophrenia. | Progress in neuro-psychopharmacology & biological psychiatry 20110115 |
| Stercoral perforation of the sigmoid colon. A case report and brief review of the literature. | Il Giornale di chirurgia 20110101 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| Comparison of the efficacy and impact on cognition of glycopyrrolate and biperiden for clozapine-induced sialorrhea in schizophrenic patients: a randomized, double-blind, crossover study. | Schizophrenia research 20100601 |
| [Doctor, I need an antidote for your antidote. A case biperidene induced anticholinergic syndrome]. | Anales de pediatria (Barcelona, Spain : 2003) 20100501 |
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| Delirium caused by intramuscular administration of biperiden. | The Journal of neuropsychiatry and clinical neurosciences 20100101 |
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| The use and potential abuse of anticholinergic antiparkinson drugs in Norway: a pharmacoepidemiological study. | British journal of clinical pharmacology 20090201 |
| Torticollis under cyclobenzaprine. | Pharmacology 20090101 |
| Biperiden enhances L-DOPA methyl ester and dopamine D(l) receptor agonist SKF-82958 but antagonizes D(2)/D(3) receptor agonist rotigotine antihemiparkinsonian actions. | European journal of pharmacology 20081203 |
| Antiparkinson drugs used as prophylactics for nerve agents: studies of cognitive side effects in rats. | Pharmacology, biochemistry, and behavior 20080601 |
| Severe extrapyramidal syndrome after exposition to isoamyl acetate vapour. | Journal of neurology 20080501 |
| A case of respiratory akathisia in a cancer patient: a case report. | Palliative & supportive care 20080301 |
| A somatic type delusional disorder secondary to peripheral neuropathy: a case report. | Psychiatria Danubina 20080301 |
| The successful use of ondansetron in a boy with both leukemia and Tourette syndrome. | Journal of child neurology 20080101 |
| Methamphetamine psychosis in which tardive dystonia was successfully treated with clonazepam. | Psychiatry and clinical neurosciences 20071201 |
| Empirical validation of competing definitions of schizophrenia: a poly-diagnostic study of cognitive impairment in non-affective psychosis. | Schizophrenia research 20070901 |
| Bipiperidinyl carboxylic acid amides as potent, selective, and functionally active CCR4 antagonists. | Chemical biology & drug design 20070901 |
| Gluteal abscess following intramuscular injection of dissolved biperiden tablets. | International journal of clinical practice 20070801 |
| Risperidone-induced sialorrhea responsive to biperiden treatment. | Schizophrenia research 20070701 |
| Development and validation of a stability-indicating high performance liquid chromatographic (HPLC) assay for biperiden in bulk form and pharmaceutical dosage forms. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070701 |
| The effectiveness of intramuscular biperiden in acute akathisia: a double-blind, randomized, placebo-controlled study. | Journal of clinical psychopharmacology 20070601 |
| Acute dystonia after injection of pegylated interferon alpha-2b. | Movement disorders : official journal of the Movement Disorder Society 20070415 |
| Neuroleptic malignant syndrome induced by ziprasidone on the second day of treatment. | The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 20070101 |
| So easy to forget. | Delaware medical journal 20070101 |
| [Therapy of postoperative nausea and vomiting in ENT--tardive dyskinesia as an adverse effect of metoclopramid--a case report]. | Laryngo- rhino- otologie 20061101 |
| Biperiden-induced delirium model in rats: a behavioral and electroencephalographic study. | Brain research 20061018 |
| Antipsychotics-induced hypersensitivity of visual perception. | European psychiatry : the journal of the Association of European Psychiatrists 20060701 |
| Acute dystonia with low-dosage aripiprazole in Tourette's disorder. | The Annals of pharmacotherapy 20060401 |
| Application of a generic physiologically based pharmacokinetic model to the estimation of xenobiotic levels in human plasma. | Drug metabolism and disposition: the biological fate of chemicals 20060101 |
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| Evaluation of the clinical efficacy of risperidone for untreated and treated cases of schizophrenia from various aspects. | Psychiatry and clinical neurosciences 20051001 |
| Scopolamine-induced convulsions in fasted mice after food intake: effects of glucose intake, antimuscarinic activity and anticonvulsant drugs. | Neuropharmacology 20050901 |
| Modulation of memory and visuospatial processes by biperiden and rivastigmine in elderly healthy subjects. | Psychopharmacology 20050901 |
| Administration of haloperidol with biperiden reduces mRNAs related to the ubiquitin-proteasome system in mice. | Synapse (New York, N.Y.) 20050615 |
| Ecstasy and acute dystonia. | Movement disorders : official journal of the Movement Disorder Society 20041101 |
| Development of a screening method for the most commonly abused anticholinergic drugs in Jordan; trihexyphenidyl, procyclidine and biperiden. | Legal medicine (Tokyo, Japan) 20041001 |
| Reversible orofacial dyskinesia after ofloxacin treatment. | Movement disorders : official journal of the Movement Disorder Society 20040601 |
| Comparisons of psychotropic drug prescribing patterns in acute psychiatric wards across Europe. | European journal of clinical pharmacology 20040301 |
| Effects of discontinuation of long-term anticholinergic treatment in elderly schizophrenia patients. | International clinical psychopharmacology 20040101 |
| [Acute dystonic reaction due to quinine]. | Anales de medicina interna (Madrid, Spain : 1984) 20031201 |
| Motor disturbances in mice with deficiency of the sodium channel gene Scn8a show features of human dystonia. | Experimental neurology 20031201 |
| Use of biperiden hydrochloride in a child with severe dyskinesia induced by phenytoin. | Journal of child neurology 20030701 |
| [Iatrogenic dementia?]. | Praxis 20030409 |
| Biperiden for excessive sweating from methadone. | The American journal of psychiatry 20030201 |
| Pharmacokinetics of intramuscularly administered biperiden in guinea pigs challenged with soman. | Drug and chemical toxicology 20030201 |
| Transient and reversible parkinsonism after acute organophosphate poisoning. | Journal of toxicology. Clinical toxicology 20030101 |
| In vitro drug-drug interactions with perospirone and concomitantly administered drugs in human liver microsomes. | European journal of drug metabolism and pharmacokinetics 20030101 |
| Tardive dyskinesia with risperidone and anticholinergics. | The American journal of psychiatry 20021101 |
| Tardive dyskinesia model in the common marmoset. | Movement disorders : official journal of the Movement Disorder Society 20020301 |
| Influence of lipophilicity and lysosomal accumulation on tissue distribution kinetics of basic drugs: a physiologically based pharmacokinetic model. | Methods and findings in experimental and clinical pharmacology 20020301 |
| The determination of biperiden in plasma using gas chromatography mass spectrometry: pharmacokinetics after intramuscular administration to guinea pigs. | Biomedical chromatography : BMC 20020201 |
| Sexual disinhibition induced by risperidone in a child. | Journal of child and adolescent psychopharmacology 20020101 |
| A case of child abuse: haloperidol poisoning of a child caused by his mother. | European journal of emergency medicine : official journal of the European Society for Emergency Medicine 20011201 |
| The influence of pilocarpine and biperiden on pH value and calcium, phosphate, and bicarbonate concentrations in saliva during and after radiotherapy for head and neck cancer. | Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20011101 |
| A cross-over clinical and electromyographic assessment of treatment for parkinsonian tremor. | Parkinsonism & related disorders 20010901 |
| Biperiden for excessive sweating from clozapine. | The American journal of psychiatry 20010801 |
| [Swollen tongue]. | Nederlands tijdschrift voor tandheelkunde 20010401 |
| Modulation by muscarinic antagonists of the response to carbon dioxide challenge in panic disorder. | Archives of general psychiatry 20010201 |
| Insomnia related to biperiden withdrawal in two schizophrenic patients. | International clinical psychopharmacology 20001101 |
| Biperiden hydrochlorate ameliorates dystonia of rats produced by microinjection of sigma ligands into the red nucleus. | Pharmacology, biochemistry, and behavior 20001101 |
| Quantitative prediction of catalepsy induced by amoxapine, cinnarizine and cyclophosphamide in mice. | Biopharmaceutics & drug disposition 20000501 |
| [A case of amoxapine-induced tardive dystonia successfully treated with a low dose anti-cholinergic agent]. | Rinsho shinkeigaku = Clinical neurology 20000401 |
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| Combined treatment of schizophrenic psychoses with haloperidol and valproate. | Pharmacopsychiatry 19980701 |
| Belly dystonia induced by levodopa and biperiden in a case of suspected multiple-system atrophy. | Movement disorders : official journal of the Movement Disorder Society 19960701 |
| Anticholinergic treatment for choreoathetosis in a child after induction with propofol. | Anesthesia and analgesia 19960301 |
| Beneficial effect of low-dose mianserin on fluvoxamine-induced akathisia in an obsessive-compulsive patient. | International clinical psychopharmacology 19950601 |
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| Bradycardia due to biperiden. | Pharmacopsychiatry 19890101 |
| Drug-induced alzheimerism. | Archives of neurology 19880301 |
| [Dyskinetic syndrome in children following Thalamonal premedication]. | Der Anaesthesist 19860401 |
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| Mood elevating effect of trihexyphenidyl and biperiden in individuals taking antipsychotic medication. | Diseases of the nervous system 19770501 |
| [Uncharacteristic hypertonia resulting from treatment with metoclopramide (Primperan) in children with acute gastroenteritis]. | Ugeskrift for laeger 19770101 |
| [Treatment of the neuroleptic syndrome by biperiden hydrochloride under its delayed-action form. A 9-month study on 55 hospitalized patients]. | L'Encephale 19760101 |
| Visual hallucinations and delirium during treatment with amantadine (Symmetrel). | Journal of the American Geriatrics Society 19750501 |
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| Dopaminergic hypersensitivity and cholinergic hypofunction in the pathophysiology of tardive dyskinesia. | Psychopharmacologia 19740109 |
| Abnormal involuntary movements induced by anticholinergic therapy. | Acta neurologica Scandinavica 19740101 |
| Phenothiazine-induced decompensation. | Archives of general psychiatry 19740101 |
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