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123122-55-4 | Cyclohexanecarboxylic acid, 4-[[[1-[(2S)-3-[(2,3-dihydro-1H-inden-5-yl)oxy]-2-[(2-methoxyethoxy)methyl]-3-oxopropyl]cyclopentyl]carbonyl]amino]-, cis-
CAS No: 123122-55-4 Catalog No: AG000K2N MDL No:MFCD00865901
Product Description
Catalog Number:
AG000K2N
Chemical Name:
Cyclohexanecarboxylic acid, 4-[[[1-[(2S)-3-[(2,3-dihydro-1H-inden-5-yl)oxy]-2-[(2-methoxyethoxy)methyl]-3-oxopropyl]cyclopentyl]carbonyl]amino]-, cis-
CAS Number:
123122-55-4
Molecular Formula:
C29H41NO7
Molecular Weight:
515.6383
MDL Number:
MFCD00865901
IUPAC Name:
4-[[1-[(2S)-3-(2,3-dihydro-1H-inden-5-yloxy)-2-(2-methoxyethoxymethyl)-3-oxopropyl]cyclopentanecarbonyl]amino]cyclohexane-1-carboxylic acid
InChI:
InChI=1S/C29H41NO7/c1-35-15-16-36-19-23(27(33)37-25-12-9-20-5-4-6-22(20)17-25)18-29(13-2-3-14-29)28(34)30-24-10-7-21(8-11-24)26(31)32/h9,12,17,21,23-24H,2-8,10-11,13-16,18-19H2,1H3,(H,30,34)(H,31,32)/t21?,23-,24?/m0/s1
InChI Key:
ZTWZVMIYIIVABD-RZMWZJFBSA-N
SMILES:
COCCOC[C@@H](C(=O)Oc1ccc2c(c1)CCC2)CC1(CCCC1)C(=O)N[C@@H]1CC[C@@H](CC1)C(=O)O
UNII:
ACP75508EE
Properties
Complexity:
772
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
1
Defined Bond Stereocenter Count:
0
Exact Mass:
515.288g/mol
Formal Charge:
0
Heavy Atom Count:
37
Hydrogen Bond Acceptor Count:
7
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
515.647g/mol
Monoisotopic Mass:
515.288g/mol
Rotatable Bond Count:
13
Topological Polar Surface Area:
111A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4
Literature
| Title | Journal |
|---|---|
| Effect of inhibition of angiotensin converting enzyme and/or neutral endopeptidase on vascular and neural complications in high fat fed/low dose streptozotocin-diabetic rats. | European journal of pharmacology 20120227 |
| Effect of Inhibition of Angiotensin-Converting Enzyme and/or Neutral Endopeptidase on Neuropathy in High-Fat-Fed C57Bl/6J Mice. | Journal of obesity 20120101 |
| Concomitant angiotensin AT1 receptor antagonism and neprilysin inhibition produces omapatrilat-like antihypertensive effects without promoting tracheal plasma extravasation in the rat. | Journal of cardiovascular pharmacology 20110401 |
| Role of the effect of inhibition of neutral endopeptidase on vascular and neural complications in streptozotocin-induced diabetic rats. | European journal of pharmacology 20110115 |
| Effect of Treatment of Sprague Dawley Rats with AVE7688, Enalapril, or Candoxatril on Diet-Induced Obesity. | Journal of obesity 20110101 |
| Rodent models for metabolic syndrome research. | Journal of biomedicine & biotechnology 20110101 |
| The application of fully automated on-line solid phase extraction in bioanalysis. | Journal of pharmaceutical and biomedical analysis 20100501 |
| Natriuretic and renoprotective effect of chronic oral neutral endopeptidase inhibition in acute renal failure. | Renal failure 20100101 |
| New function for an old enzyme: NEP deficient mice develop late-onset obesity. | PloS one 20100101 |
| Inhibition of neutral endopeptidase 24.11 does not potentiate the improvement in glycemic control obtained with dipeptidyl peptidase-4 inhibition in diabetic Goto-Kakizaki rats. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20091101 |
| Effect of bradykinin metabolism inhibitors on evoked hypotension in rats: rank efficacy of enzymes associated with bradykinin-mediated angioedema. | British journal of pharmacology 20080301 |
| Neutral endopeptidase inhibitor suppresses the early phase of atrial electrical remodeling in a canine rapid atrial pacing model. | Indian pacing and electrophysiology journal 20080101 |
| An expanded set of amino acid analogs for the ribosomal translation of unnatural peptides. | PloS one 20070101 |
| Neutral endopeptidase (EC 3.4.24.11) in cirrhotic liver: a new target to treat portal hypertension? | Journal of hepatology 20051101 |
| Neutral endopeptidase 24.11 and dipeptidyl peptidase IV are both mediators of the degradation of glucagon-like peptide 1 in the anaesthetised pig. | Diabetologia 20050901 |
| Angiotensin I-converting enzyme-dependent and neutral endopeptidase-dependent generation and degradation of angiotensin II contrarily modulate noradrenaline release: implications for vasopeptidase-inhibitor therapy? | Journal of hypertension 20050801 |
| Natriuretic and antialdosterone actions of chronic oral NEP inhibition during progressive congestive heart failure. | Kidney international 20050501 |
| Dual inhibition of angiotensin converting enzyme and neutral endopeptidase produces effective blood pressure control in spontaneously hypertensive rats. | Bratislavske lekarske listy 20050101 |
| Neutral endopeptidase 24.11 is important for the degradation of both endogenous and exogenous glucagon in anesthetized pigs. | American journal of physiology. Endocrinology and metabolism 20040901 |
| Dual inhibition of ACE and NEP provides greater cardioprotection in mice with heart failure. | Journal of cardiac failure 20040201 |
| [The new class of drugs-- metalloprotease inhibitors -- in the treatment of heart failure]. | Klinicheskaia meditsina 20040101 |
| Chronic endopeptidase inhibition in DOCA-salt hypertension: mechanism of cardiovascular protection. | Clinical and experimental hypertension (New York, N.Y. : 1993) 20030801 |
| Potentiation of urinary atrial natriuretic peptide interferes with macula densa function. | Cardiovascular research 20010815 |
| Omapatrilat, a dual angiotensin-converting enzyme and neutral endopeptidase inhibitor, prevents fatty streak deposit in apolipoprotein E-deficient mice. | Atherosclerosis 20010401 |
| Comparison of a vasopeptidase inhibitor with neutral endopeptidase and angiotensin-converting enzyme inhibitors on bradykinin metabolism in the rat coronary bed. | Journal of cardiovascular pharmacology 20010401 |
| Renal and hormonal effects of chronic inhibition of neutral endopeptidase (EC 3.4.24.11) in normal man. | Clinical science (London, England : 1979) 19930701 |
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