CAS 123-78-4 | 4-Octadecene-1,3-diol, 2-amino-, (2S,3R,4E)- | CAS Number 123-78-4

Title	Journal
Non-dioxin-like organic toxicant PCB153 modulates sphingolipid metabolism in liver progenitor cells: its role in Cx43-formed gap junction impairment.	Archives of toxicology 20170201
Effect of sphingosine kinase modulators on interleukin-1β release, sphingosine 1-phosphate receptor 1 expression and experimental autoimmune encephalomyelitis.	British journal of pharmacology 20170101
Elevated Nuclear and Cytoplasmic FTY720-Phosphate in Mouse Embryonic Fibroblasts Suggests the Potential for Multiple Mechanisms in FTY720-Induced Neural Tube Defects.	Toxicological sciences : an official journal of the Society of Toxicology 20160301
A natural piper-amide-like compound NED-135 exhibits a potent inhibitory effect on the invasive breast cancer cells.	Chemico-biological interactions 20150725
FTY720 induces autophagy-related apoptosis and necroptosis in human glioblastoma cells.	Toxicology letters 20150702
Actin polymerization-enhancing drugs promote ovarian follicle growth mediated by the Hippo signaling effector YAP.	FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20150601
FTY720 Phosphate Activates Sphingosine-1-Phosphate Receptor 2 and Selectively Couples to Gα12/13/Rho/ROCK to Induce Myofibroblast Contraction.	Molecular pharmacology 20150601
Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate.	Journal of lipid research 20150601
Apigenin attenuates heart injury in lipopolysaccharide-induced endotoxemic model by suppressing sphingosine kinase 1/sphingosine 1-phosphate signaling pathway.	Chemico-biological interactions 20150525
Lysophospholipid receptors in drug discovery.	Experimental cell research 20150501
Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3.	Journal of neuroinflammation 20150101
Resveratrol induces apoptosis of leukemia cell line K562 by modulation of sphingosine kinase-1 pathway.	International journal of clinical and experimental pathology 20150101
Downregulation of Pink1 influences mitochondrial fusion-fission machinery and sensitizes to neurotoxins in dopaminergic cells.	Neurotoxicology 20140901
Sphingosine kinase 1 and sphingosine-1-phosphate in oxidative stress evoked by 1-methyl-4-phenylpyridinium (MPP+) in human dopaminergic neuronal cells.	Molecular neurobiology 20140801
FTY720 attenuates paraquat-induced lung injury in mice.	International immunopharmacology 20140801
Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory.	Nature neuroscience 20140701
ASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile.	PloS one 20140101
Suppression of experimental autoimmune optic neuritis by the novel agent fingolimod.	Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 20130601
Circulating monocytes are reduced by sphingosine-1-phosphate receptor modulators independently of S1P3.	Journal of immunology (Baltimore, Md. : 1950) 20130401
Cellular assay for the characterization of sphingosine-1-phosphate lyase inhibitors.	Analytical biochemistry 20130315
Sphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 (TRPM7) channels.	British journal of pharmacology 20130301
Early tolerability and safety of fingolimod in clinical practice.	Journal of the neurological sciences 20121215
Contrary effects of sphingosine-1-phosphate on expression of α-smooth muscle actin in transforming growth factor β1-stimulated lung fibroblasts.	European journal of pharmacology 20121205
Fingolimod inhibits PDGF-B-induced migration of vascular smooth muscle cell by down-regulating the S1PR1/S1PR3 pathway.	Biochimie 20121201
Sphingosine 1-phosphate protects primary human keratinocytes from apoptosis via nitric oxide formation through the receptor subtype S1P₃.	Molecular and cellular biochemistry 20121201
Sphingosine-1-phosphate inhibits interleukin-1β-induced inflammation in human articular chondrocytes.	International journal of molecular medicine 20121201
Effect of alkyl chain length on sphingosine kinase 2 selectivity.	Bioorganic & medicinal chemistry letters 20121115
Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B.	International journal of cancer 20121101
Withdrawal of fingolimod treatment for relapsing-remitting multiple sclerosis: report of six cases.	Multiple sclerosis (Houndmills, Basingstoke, England) 20121101
Sphingopeptides: dihydrosphingosine-based fusion inhibitors against wild-type and enfuvirtide-resistant HIV-1.	FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20121101
Severe multiple sclerosis reactivation under fingolimod 3 months after natalizumab withdrawal.	Multiple sclerosis (Houndmills, Basingstoke, England) 20121101
Evidence for a link between histone deacetylation and Ca²+ homoeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts.	The Biochemical journal 20121101
Over-expression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis.	Journal of neurochemistry 20121101
A strategy for enrichment of the bioactive sphingoid base-1-phosphates produced by Hypericum perforatum L. in a balloon type airlift reactor.	Bioresource technology 20121101
Myocardial infarction differentially alters sphingolipid levels in plasma, erythrocytes and platelets of the rat.	Basic research in cardiology 20121101
Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity.	Endocrinology 20121101
High density lipoprotein biogenesis, cholesterol efflux, and immune cell function.	Arteriosclerosis, thrombosis, and vascular biology 20121101
Switching therapy from natalizumab to fingolimod in relapsing-remitting multiple sclerosis: clinical and magnetic resonance imaging findings.	Multiple sclerosis (Houndmills, Basingstoke, England) 20121101
Emerging tumefactive multiple sclerosis after switching therapy from natalizumab to fingolimod.	Multiple sclerosis (Houndmills, Basingstoke, England) 20121101
Focus on molecules: Sphingosine 1 Phosphate (S1P).	Experimental eye research 20121001
Sudden unexpected death on fingolimod.	Multiple sclerosis (Houndmills, Basingstoke, England) 20121001
Role of S-1-P receptors and human vascular smooth muscle cell migration in diabetes and metabolic syndrome.	The Journal of surgical research 20121001
Effects of FTY720 and rapamycin on inflammation in taurocholate-induced acute pancreatitis in the rat.	Pancreas 20121001
Phytosphingosine-1-phosphate represses the hydrogen peroxide-induced activation of c-Jun N-terminal kinase in human dermal fibroblasts through the phosphatidylinositol 3-kinase/Akt pathway.	Archives of dermatological research 20121001
Sphingosine 1-phosphate-primed astrocytes enhance differentiation of neuronal progenitor cells.	Journal of neuroscience research 20121001
Increased serum concentration of sphingosine-1-phosphate in juvenile-onset systemic lupus erythematosus.	Journal of clinical immunology 20121001
Analysis of sphingolipid and prostaglandin synthesis during zymosan-induced inflammation.	Prostaglandins & other lipid mediators 20121001
Sphingosine 1-phosphate induces MKP-1 expression via p38 MAPK- and CREB-mediated pathways in airway smooth muscle cells.	Biochimica et biophysica acta 20121001
Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate.	The Biochemical journal 20121001
New disease-modifying therapies and new challenges for MS.	Current neurology and neuroscience reports 20121001
Sphingosine-1-phosphate inhibits H2O2-induced granulosa cell apoptosis via the PI3K/Akt signaling pathway.	Fertility and sterility 20121001
Myriocin, an inhibitor of serine palmitoyl transferase, impairs the uptake of transferrin and low-density lipoprotein in mammalian cells.	Archives of biochemistry and biophysics 20121001
Erythrocyte-derived sphingosine-1-phosphate stabilizes basal hydraulic conductivity and solute permeability in rat microvessels.	American journal of physiology. Heart and circulatory physiology 20121001
Plasma sphingosine 1-phosphate levels and the risk of vertebral fracture in postmenopausal women.	The Journal of clinical endocrinology and metabolism 20121001
Sphingosine 1-phosphate and human ether-a'-go-go-related gene potassium channels modulate migration in human anaplastic thyroid cancer cells.	Endocrine-related cancer 20121001
A therapeutic approach to hyperglycaemia in the setting of acute myocardial infarction: spotlight on glucagon-like peptide 1.	Therapeutic advances in cardiovascular disease 20121001
The functional roles of S1P in immunity.	Journal of biochemistry 20121001
Stereoselective synthesis of C18-guggultetrol and C18-phytosphingosine analogues from D-fructose.	Carbohydrate research 20121001
Increased sphingoid base-1-phosphates and failure of neural tube closure after exposure to fumonisin or FTY720.	Birth defects research. Part A, Clinical and molecular teratology 20121001
Sphingolipids, lipotoxic cardiomyopathy, and cardiac failure.	Heart failure clinics 20121001
Bcl-x pre-mRNA splicing regulates brain injury after neonatal hypoxia-ischemia.	The Journal of neuroscience : the official journal of the Society for Neuroscience 20120926
Diastereodivergent hydroxyfluorination of cyclic and acyclic allylic amines: synthesis of 4-deoxy-4-fluorophytosphingosines.	The Journal of organic chemistry 20120907
The safety risks of innovation: the FDA's Expedited Drug Development Pathway.	JAMA 20120905
A randomized, controlled trial of fingolimod (FTY720) in Japanese patients with multiple sclerosis.	Multiple sclerosis (Houndmills, Basingstoke, England) 20120901
Evaluation of pathological effects in broilers during fumonisins and clays exposure.	Mycopathologia 20120901
A patient with Leiden V mutation, multiple sclerosis, psoriasis, and sicca syndrome: could celecoxib and fingolimod adversely affect the heart?	Cardiovascular toxicology 20120901
Tracking sphingosine metabolism and transport in sphingolipidoses: NPC1 deficiency as a test case.	Traffic (Copenhagen, Denmark) 20120901
The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: oxidative stress and the seesaw of cell survival and death.	Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20120901
Fingolimod--a sphingosine-like molecule inhibits vesicle mobility and secretion in astrocytes.	Glia 20120901
Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor.	Journal of neurophysiology 20120901
The hydrophobic mismatch determines the miscibility of ceramides in lipid monolayers.	Chemistry and physics of lipids 20120901
4-aminopyridine toxicity: a case report and review of the literature.	Journal of medical toxicology : official journal of the American College of Medical Toxicology 20120901
First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer.	Molecular cancer therapeutics 20120901
Fingolimod attenuates ceramide-induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes.	Acta neuropathologica 20120901
Myocardial infarction changes sphingolipid metabolism in the uninfarcted ventricular wall of the rat.	Lipids 20120901
Reporting of subgroup analyses from clinical trials.	The Lancet. Neurology 20120901
The role of sphingosine-1-phosphate in breast cancer tumor-induced lymphangiogenesis.	Lymphatic research and biology 20120901
Identification of serum-derived sphingosine-1-phosphate as a small molecule regulator of YAP.	Chemistry & biology 20120824
Effect of sphingosine 1-phosphate (S1P) receptor agonists FTY720 and CYM5442 on atherosclerosis development in LDL receptor deficient (LDL-R⁻/⁻) mice.	Vascular pharmacology 20120819
Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling.	Cell 20120817
S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma.	Blood 20120816
[Infections and fingolimod].	Revista de neurologia 20120816
Ethylene signaling pathway and MAPK cascades are required for AAL toxin-induced programmed cell death.	Molecular plant-microbe interactions : MPMI 20120801
PP2A and DUSP6 are involved in sphingosylphosphorylcholine-induced hypopigmentation.	Molecular and cellular biochemistry 20120801
Loss of GM3 synthase gene, but not sphingosine kinase 1, is protective against murine nephronophthisis-related polycystic kidney disease.	Human molecular genetics 20120801
Sphingosine-1-phosphate-induced airway hyper-reactivity in rodents is mediated by the sphingosine-1-phosphate type 3 receptor.	The Journal of pharmacology and experimental therapeutics 20120801
Immunosuppressive drugs on inducing Ag-specific CD4(+)CD25(+)Foxp3(+) Treg cells during immune response in vivo.	Transplant immunology 20120801
Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression.	Journal of lipid research 20120801
A fluorescent assay for ceramide synthase activity.	Journal of lipid research 20120801
Higher circulating sphingosine 1-phosphate levels are associated with lower bone mineral density and higher bone resorption marker in humans.	The Journal of clinical endocrinology and metabolism 20120801
Fenofibrate increases high-density lipoprotein and sphingosine 1 phosphate concentrations limiting abdominal aortic aneurysm progression in a mouse model.	The American journal of pathology 20120801
Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis.	EMBO molecular medicine 20120801
Changes in the cerebrospinal fluid ceramide profile after subarachnoid hemorrhage.	Stroke 20120801
Pharmacokinetics of fingolimod (FTY720) and a combined oral contraceptive coadministered in healthy women: drug-drug interaction study results.	International journal of clinical pharmacology and therapeutics 20120801
Pharmacologic manipulation of conventional outflow facility in ex vivo mouse eyes.	Investigative ophthalmology & visual science 20120801
Labeling Golgi with fluorescent ceramides.	Cold Spring Harbor protocols 20120801
Sphingosine-1-phosphate modulates expression of vascular endothelial growth factor in human articular chondrocytes: a possible new role in arthritis.	International journal of rheumatic diseases 20120801
[Effect of sphingosine 1-phosphate/sphingosine 1-phosphate receptor signal pathway on function of neutrophils].	Zhongguo shi yan xue ye xue za zhi 20120801
The sphingolipid degradation product trans-2-hexadecenal forms adducts with DNA.	Biochemical and biophysical research communications 20120720
Role of the lysophospholipid mediators lysophosphatidic acid and sphingosine 1-phosphate in lung fibrosis.	Proceedings of the American Thoracic Society 20120715
Proximal cerebral arteries develop myogenic responsiveness in heart failure via tumor necrosis factor-α-dependent activation of sphingosine-1-phosphate signaling.	Circulation 20120710
Population pharmacokinetics of fingolimod phosphate in healthy participants.	Journal of clinical pharmacology 20120701
Fingolimod potentiates the effects of sunitinib malate in a rat breast cancer model.	Breast cancer research and treatment 20120701
The utility of pharmacokinetic-pharmacodynamic modeling in the discovery and optimization of selective S1P(1) agonists.	Xenobiotica; the fate of foreign compounds in biological systems 20120701
A novel view of paroxysmal nocturnal hemoglobinuria pathogenesis: more motile PNH hematopoietic stem/progenitor cells displace normal HSPCs from their niches in bone marrow due to defective adhesion, enhanced migration and mobilization in response to erythrocyte-released sphingosine-1 phosphate gradient.	Leukemia 20120701
Metabolic engineering of the non-conventional yeast Pichia ciferrii for production of rare sphingoid bases.	Metabolic engineering 20120701
Penetration and release studies of positively and negatively charged nanoemulsions--is there a benefit of the positive charge?	International journal of pharmaceutics 20120701
IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia.	American journal of physiology. Lung cellular and molecular physiology 20120701
The sphingosine-1-phosphate receptor agonist FTY720 and its phosphorylated form affect the function of CD4+CD25+ T cells in vitro.	International journal of molecular medicine 20120701
The role of sphingosine-1-phosphate transporter Spns2 in immune system function.	Journal of immunology (Baltimore, Md. : 1950) 20120701
[Basic mechanisms of action of fingolimod in relation to multiple sclerosis].	Revista de neurologia 20120701
Decrease of serum sphingosine-1-phosphate levels in hemodialysis patients with secondary hyperparathyroidism treated with cinacalcet.	Clinical nephrology 20120701
Cost-effectiveness of early initiation of fingolimod versus delayed initiation after 1 year of intramuscular interferon beta-1a in patients with multiple sclerosis.	Clinical therapeutics 20120701
Sphingosine 1-phosphate acts as an activator for the porcine Gpr3 of constitutively active G protein-coupled receptors.	Journal of Zhejiang University. Science. B 20120701
[Effect of ceramide on GSTA1 in Caco-2 cells].	Yao xue xue bao = Acta pharmaceutica Sinica 20120701
[Therapeutic approach to mite-induced intractable dermatitis using novel immunomodulator FTY720 (fingolimod) in combination with betamethasone ointment in NC/Nga mice].	Arerugi = [Allergy] 20120701
Sphingosine 1-phosphate antagonizes the effect of all-trans retinoic acid (ATRA) in a human colon cancer cell line by modulation of RARβ expression.	Cancer letters 20120628
Sphingosine 1-phosphate receptor activation enhances BMP-2-induced osteoblast differentiation.	Biochemical and biophysical research communications 20120622
Species-specific activity of glycolipid ligands for invariant NKT cells.	Chembiochem : a European journal of chemical biology 20120618
First-line disease-modifying therapies in paediatric multiple sclerosis: a comprehensive overview.	Drugs 20120618
Biosynthesis of alkyl lysophosphatidic acid by diacylglycerol kinases.	Biochemical and biophysical research communications 20120615
In vivo efficacy of a novel liposomal formulation of safingol in the treatment of acute myeloid leukemia.	Journal of controlled release : official journal of the Controlled Release Society 20120610
Sphingosine 1-phosphate as a therapeutic target in heart failure: more questions than answers.	Circulation 20120605
Tumor necrosis factor-α-mediated downregulation of the cystic fibrosis transmembrane conductance regulator drives pathological sphingosine-1-phosphate signaling in a mouse model of heart failure.	Circulation 20120605
SRC regulates sphingosine-1-phosphate mediated smooth muscle cell migration.	The Journal of surgical research 20120601
Thiazolidinedione-dependent activation of sphingosine kinase 1 causes an anti-fibrotic effect in renal mesangial cells.	British journal of pharmacology 20120601
Serum sphingolipids and inflammatory mediators in adolescents at risk for metabolic syndrome.	Endocrine 20120601
FTY720 (fingolimod) increases vascular tone and blood pressure in spontaneously hypertensive rats via inhibition of sphingosine kinase.	British journal of pharmacology 20120601
Sphingosine-1-phosphate is a mediator of TNF-α action on the Na+/K+ ATPase in HepG2 cells.	Journal of cellular biochemistry 20120601
Decreased free sphingoid base concentration in the plasma of patients with chronic systolic heart failure.	Advances in medical sciences 20120601
H-Ras increases release of sphingosine resulting in down-regulation of TSP-1 in non-transformed cells.	International journal of experimental pathology 20120601
Analytical evaluation of plasma serotonin and sphingosine 1-phosphate and their clinical assessment in early atherosclerosis.	Coronary artery disease 20120601
Possible Involvement of Sphingosine-1-Phosphate/G(i)/RhoA pathways in adherence of eosinophils to pulmonary endothelium.	Allergology international : official journal of the Japanese Society of Allergology 20120601
Interplay between SAFE and RISK pathways in sphingosine-1-phosphate-induced cardioprotection.	Cardiovascular drugs and therapy 20120601
Ethanol triggers sphingosine 1-phosphate elevation along with neuroapoptosis in the developing mouse brain.	Journal of neurochemistry 20120601
FTY720 mediates activation suppression and G(0)/G (1) cell cycle arrest in a concanavalin A-induced mouse lymphocyte pan-activation model.	Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120601
Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation.	Angiogenesis 20120601
Role of sphingosine-1-phosphate inβ-adrenoceptor desensitization via Ca(2+) sensitization in airway smooth muscle.	Allergology international : official journal of the Japanese Society of Allergology 20120601
Signaling and regulatory functions of bioactive sphingolipids as therapeutic targets in multiple sclerosis.	Neurochemical research 20120601
Sphingosine mediates TNFα-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells.	Journal of lipid research 20120601
IKK NBD peptide inhibits LPS induced pulmonary inflammation and alters sphingolipid metabolism in a murine model.	Pulmonary pharmacology & therapeutics 20120601
Isoflurane delays the development of early brain injury after subarachnoid hemorrhage through sphingosine-related pathway activation in mice.	Critical care medicine 20120601
Clathrin and AP-1 regulate apical polarity and lumen formation during C. elegans tubulogenesis.	Development (Cambridge, England) 20120601
Simultaneous quantitation of sphingoid bases and their phosphates in biological samples by liquid chromatography/electrospray ionization tandem mass spectrometry.	Analytical and bioanalytical chemistry 20120601
[Assessment of the clinical and MRI results of the FREEDOMS and TRANSFORMS phase III. clinical trials].	Ideggyogyaszati szemle 20120530
The reduction of allograft arteriosclerosis in intestinal transplant is associated with sphingosine kinase 1/sphingosine-1-phosphate signaling after fish oil treatment.	Transplantation 20120527
The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway.	Molecular cell 20120525
Structure of the first sphingosine 1-phosphate receptor.	Science signaling 20120522
FTY720, sphingosine 1-phosphate receptor modulator, selectively radioprotects hippocampal neural stem cells.	Neuroscience letters 20120516
Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1.	The Biochemical journal 20120515
Attenuation by sphingosine-1-phosphate of rat microvessel acute permeability response to bradykinin is rapidly reversible.	American journal of physiology. Heart and circulatory physiology 20120515
Pharmacological effects of CS-0777, a selective sphingosine 1-phosphate receptor-1 modulator: results from a 12-week, open-label pilot study in multiple sclerosis patients.	Journal of neuroimmunology 20120515
Sphingosine analogue AAL-R increases TLR7-mediated dendritic cell responses via p38 and type I IFN signaling pathways.	Journal of immunology (Baltimore, Md. : 1950) 20120515
Building a better sphingosine kinase-1 inhibitor.	The Biochemical journal 20120515
[Multiple sclerosis: beyong first line therapies].	Revue medicale suisse 20120502
Pharmacologic recruitment of regulatory T cells as a therapy for ischemic acute kidney injury.	Kidney international 20120501
Sphingosine-1-phosphate-induced release of TIMP-2 from vascular smooth muscle cells inhibits angiogenesis.	Journal of cell science 20120501
Sphingosine-1-phosphate receptor-3 signaling up-regulates epidermal growth factor receptor and enhances epidermal growth factor receptor-mediated carcinogenic activities in cultured lung adenocarcinoma cells.	International journal of oncology 20120501
S1P2 receptor mediates sphingosine-1-phosphate-induced fibronectin expression via MAPK signaling pathway in mesangial cells under high glucose condition.	Experimental cell research 20120501
Sorafenib inhibits endogenous and IL-6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis.	Cancer biology & therapy 20120501
Specific phosphorylation of αA-crystallin is required for the αA-crystallin-induced protection of astrocytes against staurosporine and C2-ceramide toxicity.	Neurochemistry international 20120501
Low-density lipoprotein induced expression of connective tissue growth factor via transactivation of sphingosine 1-phosphate receptors in mesangial cells.	Molecular endocrinology (Baltimore, Md.) 20120501
An efficient synthesis of the polar part of sulfamisterin and its analogs.	Carbohydrate research 20120501
Annualized relapse rate of first-line treatments for multiple sclerosis: a meta-analysis, including indirect comparisons versus fingolimod.	Current medical research and opinion 20120501
Miglustat improves purkinje cell survival and alters microglial phenotype in feline Niemann-Pick disease type C.	Journal of neuropathology and experimental neurology 20120501
MS clinical trials: what can subgroup analyses teach us?	The Lancet. Neurology 20120501
Relapse and disability outcomes in patients with multiple sclerosis treated with fingolimod: subgroup analyses of the double-blind, randomised, placebo-controlled FREEDOMS study.	The Lancet. Neurology 20120501
Harnessing regulatory T cells for therapeutic purposes.	Kidney international 20120501
Immunotherapies in neurologic disorders.	The Medical clinics of North America 20120501
Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia.	Nature 20120426
Lysophosphatidic acid and sphingosine-1-phosphate promote morphogenesis and block invasion of prostate cancer cells in three-dimensional organotypic models.	Oncogene 20120419
[New disease-modifying and symptomatic therapies for multiple sclerosis].	MMW Fortschritte der Medizin 20120419
Treatment with a sphingosine-1-phosphate analog inhibits airway remodeling following repeated allergen exposure.	American journal of physiology. Lung cellular and molecular physiology 20120415
Sphingosine 1-phosphate (S1P) regulates glucose-stimulated insulin secretion in pancreatic beta cells.	The Journal of biological chemistry 20120413
Drugs: An injection of hope.	Nature 20120412
Autophagy induced by FTY720 promotes apoptosis in U266 cells.	European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120411
CCR7/CCL19 controls expression of EDG-1 in T cells.	The Journal of biological chemistry 20120406
The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice.	The Journal of clinical investigation 20120402
Treatments for relapsing-remitting multiple sclerosis: summarising current information by network meta-analysis.	European journal of clinical pharmacology 20120401
Placebo-controlled study of the effects of fingolimod on cardiac rate and rhythm and pulmonary function in healthy volunteers.	European journal of clinical pharmacology 20120401
Reactivating PP2A by FTY720 as a novel therapy for AML with C-KIT tyrosine kinase domain mutation.	Journal of cellular biochemistry 20120401
Regulation of metabolism and transport of sphingosine-1-phosphate in mammalian cells.	Molecular and cellular biochemistry 20120401
Senescent endothelial dysfunction is attributed to the up-regulation of sphingosine-1-phosphate receptor-2 in aged rats.	Molecular and cellular biochemistry 20120401
Methylation of glycosylated sphingolipid modulates membrane lipid topography and pathogenicity of Cryptococcus neoformans.	Cellular microbiology 20120401
Reactive murine lymph nodes uniquely permit parenchymal access for T cells that enter via the afferent lymphatics.	The Journal of pathology 20120401
A polysaccharides MDG-1 augments survival in the ischemic heart by inducing S1P release and S1P1 expression.	International journal of biological macromolecules 20120401
Pharmacological mechanisms of black cohosh in Sprague-Dawley rats.	Fitoterapia 20120401
Phytosphingosine-phosphate is a signal for AtMPK6 activation and Arabidopsis response to chilling.	The New phytologist 20120401
Sphingosine pathway deregulation in endometriotic tissues.	Fertility and sterility 20120401
Sphingosine-1-phosphate receptor 3 promotes neointimal hyperplasia in mouse iliac-femoral arteries.	Arteriosclerosis, thrombosis, and vascular biology 20120401
Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin α(v)β(6)-dependent physical force.	Experimental cell research 20120401
Rapid histamine-induced neutrophil recruitment is sphingosine kinase-1 dependent.	The American journal of pathology 20120401
An efficient and convenient formal synthesis of Jaspine B from D-xylose.	Carbohydrate research 20120401
Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma.	Neuro-oncology 20120401
Evidence that sphingolipid signaling is involved in responding to low temperature.	The New phytologist 20120401
Anti-proliferative effects of the novel ceramide analog (S)-2-(benzylideneamino)-3-hydroxy-N-tetrade-cylpropanamide in chemoresistant cancer.	Bioorganic & medicinal chemistry letters 20120401
FTY720 improves functional recovery after spinal cord injury by primarily nonimmunomodulatory mechanisms.	The American journal of pathology 20120401
Network analysis of randomized controlled trials in multiple sclerosis.	Clinical therapeutics 20120401
[2012: Update on diagnosis and treatment of multiple sclerosis].	Deutsche medizinische Wochenschrift (1946) 20120401
Fingolimod: cardiovascular deaths.	Prescrire international 20120401
Discovery of fingolimod, the sphingosine 1-phosphate receptor modulator and its application for the therapy of multiple sclerosis.	Future medicinal chemistry 20120401
Protein phosphatase 1α mediates ceramide-induced ERM protein dephosphorylation: a novel mechanism independent of phosphatidylinositol 4, 5-biphosphate (PIP2) and myosin/ERM phosphatase.	The Journal of biological chemistry 20120323
Blocking S1P interaction with S1P₁ receptor by a novel competitive S1P₁-selective antagonist inhibits angiogenesis.	Biochemical and biophysical research communications 20120323
Severe multiple sclerosis relapse under fingolimod therapy: incident or coincidence?	Neurology 20120320
S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release.	Blood 20120315
Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis.	European journal of pharmacology 20120315
Synthesis of amino core compounds of galactosyl phytosyl ceramide analogs for developing iNKT-cell inducers.	Molecules (Basel, Switzerland) 20120312
Connections between sphingosine kinase and phospholipase D in the abscisic acid signaling pathway in Arabidopsis.	The Journal of biological chemistry 20120309
Sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling regulates receptor activator of NF-κB ligand (RANKL) expression in rheumatoid arthritis.	Biochemical and biophysical research communications 20120309
Local delivery of FTY720 accelerates cranial allograft incorporation and bone formation.	Cell and tissue research 20120301
Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages.	European journal of immunology 20120301
High-level production of tetraacetyl phytosphingosine (TAPS) by combined genetic engineering of sphingoid base biosynthesis and L-serine availability in the non-conventional yeast Pichia ciferrii.	Metabolic engineering 20120301
Co-regulation of transcellular and paracellular leak across microvascular endothelium by dynamin and Rac.	The American journal of pathology 20120301
Prevention of GVHD and graft rejection by a new S1P receptor agonist, W-061, in rat small bowel transplantation.	Transplant immunology 20120301
Sphingosine-1-phosphate induces contraction of valvular interstitial cells from porcine aortic valves.	Cardiovascular research 20120301
Targeting sphingosine kinase-1 to inhibit melanoma.	Pigment cell & melanoma research 20120301
Metabolic profiling based on LC/MS to evaluate unintended effects of transgenic rice with cry1Ac and sck genes.	Plant molecular biology 20120301
Terpene alcohols inhibit de novo sphingolipid biosynthesis.	Planta medica 20120301
Bioactive sphingolipids in docetaxel-induced apoptosis in human prostate cancer cells.	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20120301
LC-MS/MS determination of FTY720 and FTY720-phosphate in murine intracellular compartments and human plasma.	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120301
FTY720-induced blockage of autophagy enhances anticancer efficacy of milatuzumab in mantle cell lymphoma: is FTY720 the next autophagy-blocking agent in lymphoma treatment?	Autophagy 20120301
FTY720 on the way from the base camp to the summit of the mountain: relevance for remyelination.	Multiple sclerosis (Houndmills, Basingstoke, England) 20120301
Fingolimod blocks immunosurveillance of myeloma and B-cell lymphoma resulting in cancer development in mice.	Blood 20120301
[Effect of sphingosine-1-phosphate on chemotherapy-induced ovarian damage and on the efficacy of chemotherapy in mice bearing S180 tumor].	Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20120301
[Ca2+ and sphingolipids as modulators for apoptosis and cancer].	Investigacion clinica 20120301
Comparative effects of fumonisins on sphingolipid metabolism and toxicity in ducks and turkeys.	Avian diseases 20120301
Immunological function of sphingosine 1-phosphate in the intestine.	Nutrients 20120301
Simvastatin inhibits sphingosylphosphorylcholine-induced differentiation of human mesenchymal stem cells into smooth muscle cells.	Experimental & molecular medicine 20120227
Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection.	British journal of cancer 20120227
Fingolimod-associated macular edema: incidence, detection, and management.	Neurology 20120227
Agency is under fire for refusing to supply details of sudden deaths after first dose of multiple sclerosis drug.	BMJ (Clinical research ed.) 20120223
ABCA1, ABCG1, and SR-BI: Transit of HDL-associated sphingosine-1-phosphate.	Clinica chimica acta; international journal of clinical chemistry 20120218
FTY720 normalizes hyperglycemia by stimulating β-cell in vivo regeneration in db/db mice through regulation of cyclin D3 and p57(KIP2).	The Journal of biological chemistry 20120217
Analysis of sphingosine-1-phosphate signaling mutants reveals endodermal requirements for the growth but not dorsoventral patterning of jaw skeletal precursors.	Developmental biology 20120215
Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy.	Oncogene 20120202
Sphingosine-1-phosphate attenuates lung injury induced by intestinal ischemia/reperfusion in mice: role of inducible nitric-oxide synthase.	Inflammation 20120201
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.	Acta physiologica (Oxford, England) 20120201
Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide.	International journal of cancer 20120201
Integration of transient receptor potential canonical channels with lipids.	Acta physiologica (Oxford, England) 20120201
Oral fingolimod rescues the functional deficits of synapses in experimental autoimmune encephalomyelitis.	British journal of pharmacology 20120201
Targeting synaptic pathology in multiple sclerosis: fingolimod to the rescue?	British journal of pharmacology 20120201
[Fingolimod treatment for multiple sclerosis patients. Infectiological aspects and recommendations for vaccinations].	Der Nervenarzt 20120201
Inhibitors of specific ceramide synthases.	Biochimie 20120201
Distinct generation, pharmacology, and distribution of sphingosine 1-phosphate and dihydrosphingosine 1-phosphate in human neural progenitor cells.	Neuropharmacology 20120201
Sphingosine 1-phosphate-mediated α1B-adrenoceptor desensitization and phosphorylation. Direct and paracrine/autocrine actions.	Biochimica et biophysica acta 20120201
S1P(1) receptor modulation with cyclical recovery from lymphopenia ameliorates mouse model of multiple sclerosis.	Molecular pharmacology 20120201
Inhibition of sphingosine 1-phosphate receptor 2 protects against renal ischemia-reperfusion injury.	Journal of the American Society of Nephrology : JASN 20120201
Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition.	Thorax 20120201
Therapeutic dosing of fingolimod (FTY720) prevents cell infiltration, rapidly suppresses ocular inflammation, and maintains the blood-ocular barrier.	The American journal of pathology 20120201
Sphingosine kinase 1 knockdown reduces insulin synthesis and secretion in a rat insulinoma cell line.	Archives of biochemistry and biophysics 20120201
Immune regulation by sphingosine 1-phosphate and its receptors.	Archivum immunologiae et therapiae experimentalis 20120201
Sphingosine 1-phosphate stimulates proliferation and migration of satellite cells: role of S1P receptors.	Biochimica et biophysica acta 20120201
Sphingosine-sphingosine-1-phosphate pathway regulates trophoblast differentiation and syncytialization.	Reproductive biomedicine online 20120201
Lipid ingredients in moisturizers can modulate skin responses to UV in barrier-disrupted human skin in vivo.	Journal of dermatological science 20120201
Does fingolimod in multiple sclerosis patients cause macular edema?	Journal of neurology 20120201
Sphingosine 1-phosphate signalling in cancer.	Biochemical Society transactions 20120201
Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways.	Cell cycle (Georgetown, Tex.) 20120201
Determination of sphingosine-1-phosphate lyase activity by gas chromatography coupled to electron impact mass spectrometry.	Chemistry and physics of lipids 20120201
Application of ultra-performance liquid chromatography coupled with mass spectrometry to metabonomic study on spontaneously hypertensive rats and intervention effects of Ping Gan prescription.	Journal of separation science 20120201
Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis.	Cancer research 20120201
Fingolimod for multiple sclerosis.	Drug and therapeutics bulletin 20120201
Rebound of disease activity after withdrawal of fingolimod (FTY720) treatment.	Archives of neurology 20120201
Synthesis and immunomodulating activity of new analogues of fingolimod.	Archiv der Pharmazie 20120201
[Role of S1P acting both inside and outside the cells].	Seikagaku. The Journal of Japanese Biochemical Society 20120201
[Antitumor effect of sphingosine kinase 1 inhibitor in combination with chemotherapy on SGC7901 gastric cancer cells in vitro].	Zhonghua zhong liu za zhi [Chinese journal of oncology] 20120201
Fingolimod for multiple sclerosis.	The New England journal of medicine 20120126
Fast simultaneous quantitative analysis of FTY720 and its metabolite FTY720-P in human blood by on-line solid phase extraction coupled with liquid chromatography-tandem mass spectrometry.	Journal of pharmaceutical and biomedical analysis 20120125
Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice.	Blood 20120119
PBSCs Sphingoling along S1P/S1P1 axis.	Blood 20120119
Bioactive lipids from the sponge Spirastrella abata.	Bioorganic & medicinal chemistry letters 20120115
[Neurology].	Revue medicale suisse 20120111
Sphingosine-1-phosphate rapidly increases cortisol biosynthesis and the expression of genes involved in cholesterol uptake and transport in H295R adrenocortical cells.	Molecular and cellular endocrinology 20120102
Fingolimod in multiple sclerosis: mechanisms of action and clinical efficacy.	Clinical immunology (Orlando, Fla.) 20120101
Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia-reperfusion.	Journal of hepatology 20120101
Conditioning for hematopoietic transplantation activates the complement cascade and induces a proteolytic environment in bone marrow: a novel role for bioactive lipids and soluble C5b-C9 as homing factors.	Leukemia 20120101
Sphingosine 1-phosphate in coagulation and inflammation.	Seminars in immunopathology 20120101
The sphingosine-1-phosphate receptor agonist FTY720 prevents the development of anti-glomerular basement membrane glomerulonephritis.	Molecular biology reports 20120101
Increased interaction of connexin43 with zonula occludens-1 during inhibition of gap junctions by G protein-coupled receptor agonists.	Cellular signalling 20120101
Nuclear sphingolipid metabolism.	Annual review of physiology 20120101
Role of FAK in S1P-regulated endothelial permeability.	Microvascular research 20120101
Sphingosylphosphorylcholine induces stress fiber formation via activation of Fyn-RhoA-ROCK signaling pathway in fibroblasts.	Cellular signalling 20120101
The natural cardioprotective particle HDL modulates connexin43 gap junction channels.	Cardiovascular research 20120101
Absence of integrin αvβ3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation.	American journal of respiratory and critical care medicine 20120101
Sphingosine-1-phosphate signaling and its role in disease.	Trends in cell biology 20120101
CCR7 with S1P1 signaling through AP-1 for migration of Foxp3+ regulatory T-cells controls autoimmune exocrinopathy.	The American journal of pathology 20120101
Sphingosine in plants--more riddles from the Sphinx?	The New phytologist 20120101
Novel immunomodulators based on an oxazolin-2-one-4-carboxamide scaffold.	Bioorganic & medicinal chemistry letters 20120101
Amelioration of collagen-induced arthritis by a novel S1P1 antagonist with immunomodulatory activities.	Journal of immunology (Baltimore, Md. : 1950) 20120101
Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors.	Bioorganic & medicinal chemistry 20120101
Human vascular endothelial cells reduce sphingosylphosphorylcholine-induced smooth muscle cell contraction in co-culture system through integrin β4 and Fyn.	Acta pharmacologica Sinica 20120101
Development of extensive brain lesions following fingolimod (FTY720) treatment in a patient with neuromyelitis optica spectrum disorder.	Multiple sclerosis (Houndmills, Basingstoke, England) 20120101
Clinical pharmacokinetics of fingolimod.	Clinical pharmacokinetics 20120101
Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs.	Annual review of immunology 20120101
Structure-activity relationship studies of S1P agonists with a dihydronaphthalene scaffold.	Bioorganic & medicinal chemistry letters 20120101
Both exogenous commensal and endogenous self antigens stimulate T cell proliferation under lymphopenic conditions.	Cellular immunology 20120101
Molecular and functional characterization of the ceramide synthase from Trypanosoma cruzi.	Molecular and biochemical parasitology 20120101
The ligand binding region of the sigma-1 receptor: studies utilizing photoaffinity probes, sphingosine and N-alkylamines.	Current pharmaceutical design 20120101
Sphingosine kinase 1 mediation of expression of the anaphylatoxin receptor C5L2 dampens the inflammatory response to endotoxin.	PloS one 20120101
FTY720 suppresses liver tumor metastasis by reducing the population of circulating endothelial progenitor cells.	PloS one 20120101
Sphingosine-1 phosphate prevents ethanol-induced corneal epithelial apoptosis.	Indian journal of ophthalmology 20120101
[Research progress of the selective sphingosine-1-phosphate receptor 1 agonists].	Yao xue xue bao = Acta pharmaceutica Sinica 20120101
Small molecule inhibitors of the Pyk2 and FAK kinases modulate chemoattractant-induced migration, adhesion and Akt activation in follicular and marginal zone B cells.	Cellular immunology 20120101
Topical application of FTY720 and cyclosporin A prolong corneal graft survival in mice.	Molecular vision 20120101
Biochemical methods for quantifying sphingolipids: ceramide, sphingosine, sphingosine kinase-1 activity, and sphingosine-1-phosphate.	Methods in molecular biology (Clifton, N.J.) 20120101
Isoform-selective assays for sphingosine kinase activity.	Methods in molecular biology (Clifton, N.J.) 20120101
Quantification of sphingosine-1-phosphate and related sphingolipids by liquid chromatography coupled to tandem mass spectrometry.	Methods in molecular biology (Clifton, N.J.) 20120101
A cleanup method for mass spectrometry of sphingosine-1-phosphate in blood and solid tissues using a phosphate capture molecule.	Methods in molecular biology (Clifton, N.J.) 20120101
Immunohistochemical detection of sphingosine-1-phosphate and sphingosine kinase-1 in human tissue samples.	Methods in molecular biology (Clifton, N.J.) 20120101
Assessment of sphingosine-1-phosphate activity in biological samples by receptor internalization and adherens junction formation.	Methods in molecular biology (Clifton, N.J.) 20120101
Optimized protocols to analyze sphingosine-1-phosphate signal transduction pathways during acrosomal exocytosis in human sperm.	Methods in molecular biology (Clifton, N.J.) 20120101
Use of intravital microscopy and in vitro chemotaxis assays to study the roles of sphingosine-1-phosphate in bone homeostasis.	Methods in molecular biology (Clifton, N.J.) 20120101
Sphingosine-1-phosphate signaling in skeletal muscle cells.	Methods in molecular biology (Clifton, N.J.) 20120101
Maintenance of human embryonic stem cells by sphingosine-1-phosphate and platelet-derived growth factor.	Methods in molecular biology (Clifton, N.J.) 20120101
Ceramide and sphingosine-1-phosphate signaling in embryonic stem cell differentiation.	Methods in molecular biology (Clifton, N.J.) 20120101
Sphingosine-1-phosphate signaling in neural progenitors.	Methods in molecular biology (Clifton, N.J.) 20120101
Utilizing sphingosine-1-phosphate to stimulate sprouting angiogenesis.	Methods in molecular biology (Clifton, N.J.) 20120101
The role of sphingosine kinase 1/sphingosine-1-phosphate pathway in the myogenic tone of posterior cerebral arteries.	PloS one 20120101
Lymphocyte modulation with FTY720 improves hemorrhagic shock survival in swine.	PloS one 20120101
Disparate in vivo efficacy of FTY720 in xenograft models of Philadelphia positive and negative B-lineage acute lymphoblastic leukemia.	PloS one 20120101
Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through a S1PR2/STAT3 signaling pathway.	PloS one 20120101
Ensemble analysis of angiogenic growth in three-dimensional microfluidic cell cultures.	PloS one 20120101
Sphingosine-1-phosphate signaling in physiology and diseases.	BioFactors (Oxford, England) 20120101
Regulation of interleukin-1alpha and tumor necrosis factor-alpha-induced interleukin-8 production by amnion-derived (WISH) cells.	Clinical and experimental obstetrics & gynecology 20120101
[Sphingosine-1-phosphate signaling system and the innovative mechanism of action of fingolimod in treatment of multiple sclerosis: review of foreign literature].	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20120101
The G protein coupled receptor 3 is involved in cAMP and cGMP signaling and maintenance of meiotic arrest in porcine oocytes.	PloS one 20120101
Topographical and biological evidence revealed FTY720-mediated anergy-polarization of mouse bone marrow-derived dendritic cells in vitro.	PloS one 20120101
Oral FTY720 administration induces immune tolerance and inhibits early development of atherosclerosis in apolipoprotein E-deficient mice.	International journal of immunopathology and pharmacology 20120101
Mouse SPNS2 functions as a sphingosine-1-phosphate transporter in vascular endothelial cells.	PloS one 20120101
Effect of FTY720 on some physiological indexes of Non-Obese Diabetic (NOD) Mice.	International journal of molecular sciences 20120101
Targeting sphingosine kinase 1 in carcinoma cells decreases proliferation and survival by compromising PKC activity and cytokinesis.	PloS one 20120101
Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells.	Asian Pacific journal of cancer prevention : APJCP 20120101
Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats.	PloS one 20120101
Therapeutic approach to steroid-resistant dermatitis using novel immunomodulator FTY720 (Fingolimod) in combination with betamethasone ointment in NC/Nga mice.	Biological & pharmaceutical bulletin 20120101
The essential structures of ISP-I that influence serine palmitoyltransferase inhibition in Chinese hamster ovary cells.	Biological & pharmaceutical bulletin 20120101
Dealing with excess of zeros in the statistical analysis of magnetic resonance imaging lesion count in multiple sclerosis.	Pharmaceutical statistics 20120101
Development of oral agent in the treatment of multiple sclerosis: how the first available oral therapy, fingolimod will change therapeutic paradigm approach.	Drug design, development and therapy 20120101
Fingolimod in the treatment algorithm of relapsing remitting multiple sclerosis: a statement of the Central and East European (CEE) MS Expert Group.	Wiener medizinische Wochenschrift (1946) 20120101
4,8-Sphingadienine and 4-hydroxy-8-sphingenine activate ceramide production in the skin.	Lipids in health and disease 20120101
[Changes in content of glycolipids, sphingosine and cytokines in the rat brain with experimental edema].	Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20120101
Metabolic profiling reveals sphingosine-1-phosphate kinase 2 and lyase as key targets of (phyto-) estrogen action in the breast cancer cell line MCF-7 and not in MCF-12A.	PloS one 20120101
Synthesis of a key intermediate for the preparation of FTY720 analogs.	Chemical & pharmaceutical bulletin 20120101
Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage.	The Journal of biological chemistry 20111230
FTY720 increases CD74 expression and sensitizes mantle cell lymphoma cells to milatuzumab-mediated cell death.	Blood 20111222
Effects of sphingosine 2N- and 3O-methylation on palmitoyl ceramide properties in bilayer membranes.	Biophysical journal 20111221
Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate.	The Biochemical journal 20111215
The in vitro metabolism of sphingosine-1-phosphate: identification; inhibition and pharmacological implications.	European journal of pharmacology 20111215
Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart.	Circulation 20111213
Fluid shear stress and sphingosine 1-phosphate activate calpain to promote membrane type 1 matrix metalloproteinase (MT1-MMP) membrane translocation and endothelial invasion into three-dimensional collagen matrices.	The Journal of biological chemistry 20111209
Asymmetric synthesis and cytotoxic activity of isomeric phytosphingosine derivatives.	Organic & biomolecular chemistry 20111207
Plasma levels of sphingosine 1-phosphate are strongly correlated with haematocrit, but variably restored by red blood cell transfusions.	Clinical science (London, England : 1979) 20111201
ATP-binding cassette ABCC1 is involved in the release of sphingosine 1-phosphate from rat uterine leiomyoma ELT3 cells and late pregnant rat myometrium.	Cellular signalling 20111201
Novel participation of transglutaminase-2 through c-Jun N-terminal kinase activation in sphingosylphosphorylcholine-induced keratin reorganization of PANC-1 cells.	Biochimica et biophysica acta 20111201
Differential involvement of ezrin/radixin/moesin proteins in sphingosine 1-phosphate-induced human pulmonary endothelial cell barrier enhancement.	Cellular signalling 20111201
Disruption of the ceramide synthase LOH1 causes spontaneous cell death in Arabidopsis thaliana.	The New phytologist 20111201
Development of small-molecule inhibitors of sphingosine-1-phosphate signaling.	Pharmacology & therapeutics 20111201
Integral hair lipid in human hair follicle.	Journal of dermatological science 20111201
Pericyte-derived sphingosine 1-phosphate induces the expression of adhesion proteins and modulates the retinal endothelial cell barrier.	Arteriosclerosis, thrombosis, and vascular biology 20111201
Plasma levels of sphingosine-1-phosphate and apolipoprotein M in patients with monogenic disorders of HDL metabolism.	Atherosclerosis 20111201
Complex modulation of peptidolytic activity of cathepsin D by sphingolipids.	Biochimica et biophysica acta 20111201
Sphingosine kinase-1 pathway mediates high glucose-induced fibronectin expression in glomerular mesangial cells.	Molecular endocrinology (Baltimore, Md.) 20111201
Extracellular and intracellular sphingosine-1-phosphate in cancer.	Cancer metastasis reviews 20111201
Phospholipase C and protein kinase C-β 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation.	Molecular endocrinology (Baltimore, Md.) 20111201
Sphingosine-1-phosphate signalling induces the production of Lcn-2 by macrophages to promote kidney regeneration.	The Journal of pathology 20111201
The debut of a rational treatment for an inherited neuropathy?	The Journal of clinical investigation 20111201
Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1.	The Journal of clinical investigation 20111201
[Bone and calcium update; bone research update. Trafficking of osteoclast precursors visualized by intravital imaging technology].	Clinical calcium 20111201
Role of the sphingosine rheostat in the regulation of cnidarian-dinoflagellate symbioses.	The Biological bulletin 20111201
Cardioprotective role of sphingosine-1-phosphate.	Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20111201
Setting the clock for recirculating lymphocytes.	Science signaling 20111108
Effects of S1P on skeletal muscle repair/regeneration during eccentric contraction.	Journal of cellular and molecular medicine 20111101
Regulation of apoptosis and autophagy by sphingosylphosphorylcholine in vascular endothelial cells.	Journal of cellular physiology 20111101
Exercise increases plasma levels of sphingoid base-1 phosphates in humans.	Acta physiologica (Oxford, England) 20111101
FTY720-induced conversion of conventional Foxp3- CD4+ T cells to Foxp3+ regulatory T cells in NOD mice.	American journal of reproductive immunology (New York, N.Y. : 1989) 20111101
Delayed fingolimod-associated asystole.	Multiple sclerosis (Houndmills, Basingstoke, England) 20111101
Sphingosylphosphorylcholine attenuated β-amyloid production by reducing BACE1 expression and catalysis in PC12 cells.	Neurochemical research 20111101
Sphingolipid metabolism and leukemia: a potential for novel therapeutic approaches.	Anti-cancer agents in medicinal chemistry 20111101
Hypoxia-inducible factors and sphingosine 1-phosphate signaling.	Anti-cancer agents in medicinal chemistry 20111101
Regulation of autophagy by sphingolipids.	Anti-cancer agents in medicinal chemistry 20111101
S1P regulation of macrophage functions in the context of cancer.	Anti-cancer agents in medicinal chemistry 20111101
Targeting sphingosine-1-phosphate receptors in cancer.	Anti-cancer agents in medicinal chemistry 20111101
Targeting sphingosine-1-phosphate in hematologic malignancies.	Anti-cancer agents in medicinal chemistry 20111101
Oral fingolimod (FTY720) in relapsing multiple sclerosis: impact on health-related quality of life in a phase II study.	Multiple sclerosis (Houndmills, Basingstoke, England) 20111101
Sphingosine kinase 1/S1P pathway involvement in the GDNF-induced GAP43 transcription.	Journal of cellular biochemistry 20111101
Involvement of leukotriene B4 in spontaneous itch-related behaviour in NC mice with atopic dermatitis-like skin lesions.	Experimental dermatology 20111101
Sphingosine-1-phospate receptor 4 (S1P₄) deficiency profoundly affects dendritic cell function and TH17-cell differentiation in a murine model.	FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20111101
The involvement of jasmonates and ethylene in Alternaria alternata f. sp. lycopersici toxin-induced tomato cell death.	Journal of experimental botany 20111101
FTY720 combined with tacrolimus in de novo renal transplantation: 1-year, multicenter, open-label randomized study.	Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20111101
Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules.	Cancer research 20111101
Background and rationale for mechanism of action, efficacy, and safety of fingolimod (Gilenya), the first oral therapy for remitting-relapsing multiple sclerosis: with special emphasis upon visual safety.	Current opinion in ophthalmology 20111101
Diastereoselective synthesis and bioactivity of long-chain anti-2-amino-3-alkanols.	European journal of medicinal chemistry 20111101
A novel role for mitochondrial sphingosine-1-phosphate produced by sphingosine kinase-2 in PTP-mediated cell survival during cardioprotection.	Basic research in cardiology 20111101
Oral treatment for multiple sclerosis.	The Lancet. Neurology 20111101
Short-term immunossupressive treatment of the donor does not prevent ischemia-reperfusion kidney damage in the rat.	Transplantation proceedings 20111101
[Multiple sclerosis: current therapies and future perspectives].	Nihon rinsho. Japanese journal of clinical medicine 20111101
C(6)-ceramide enhances phagocytic activity of Kupffer cells through the production of endogenous ceramides.	Molecules and cells 20111031
Syntheses of sulfur and selenium analogues of pachastrissamine via double displacements of cyclic sulfate.	Organic & biomolecular chemistry 20111021
Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors.	Chemical reviews 20111012
Lysosomal storage causes cellular dysfunction in mucolipidosis II skin fibroblasts.	The Journal of biological chemistry 20111007
Involvement of the PLCε/PKCα pathway in human BIU-87 bladder cancer cell proliferation.	Cell biology international 20111001
Non-phosphorylated FTY720 induces apoptosis of human microglia by activating SREBP2.	Cellular and molecular neurobiology 20111001
(R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells.	Cellular signalling 20111001
G-protein-coupled receptors in control of natural killer cell migration.	Trends in immunology 20111001
Defective T cell chemotaxis to sphingosine 1-phosphate and chemokine CCL21 in idiopathic T lymphocytopenia.	Journal of clinical immunology 20111001
Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury.	American journal of physiology. Heart and circulatory physiology 20111001
Role of sphingolipids in murine radiation-induced lung injury: protection by sphingosine 1-phosphate analogs.	FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20111001
GVI phospholipase A2 role in the stimulatory effect of sphingosine-1-phosphate on TRPC5 cationic channels.	Cell calcium 20111001
Sphingosine-1-phosphate induced vasoconstriction is increased in the isolated perfused kidneys of diabetic rats.	Diabetes research and clinical practice 20111001
Fingolimod for multiple sclerosis: mechanism of action, clinical outcomes, and future directions.	Current neurology and neuroscience reports 20111001
Mechanisms involved in α1B-adrenoceptor desensitization.	IUBMB life 20111001
The compartmentalization and translocation of the sphingosine kinases: mechanisms and functions in cell signaling and sphingolipid metabolism.	Critical reviews in biochemistry and molecular biology 20111001
The role of sphingolipids in respiratory disease.	Therapeutic advances in respiratory disease 20111001
Reactive oxygen species as transducers of sphinganine-mediated cell death pathway.	Plant signaling & behavior 20111001
Fingolimod treatment for multiple sclerosis patients What do we do with varicella?	Annals of neurology 20111001
[The study of FTY720 on inducing apoptosis and autophagy in multiple myeloma cell line U266].	Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20111001
GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood.	Science (New York, N.Y.) 20110930
A facile synthesis of D-ribo-C(20)-phytosphingosine and its C2 epimer from D-ribose.	Carbohydrate research 20110927
Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia.	Biochemical and biophysical research communications 20110923
The sphingosine-1-phosphate derivative NHOBTD inhibits angiogenesis both in vitro and in vivo.	Biochemical and biophysical research communications 20110923
The effect of FTY720 in the Theiler's virus model of multiple sclerosis.	Journal of the neurological sciences 20110915
Pachastrissamine (jaspine B) and its stereoisomers inhibit sphingosine kinases and atypical protein kinase C.	Bioorganic & medicinal chemistry 20110915
Therapeutic potential of targeting sphingosine kinase 1 in prostate cancer.	Nature reviews. Urology 20110913
Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia.	Blood 20110908
FTY720 (Gilenya) phosphate selectivity of sphingosine 1-phosphate receptor subtype 1 (S1P1) G protein-coupled receptor requires motifs in intracellular loop 1 and transmembrane domain 2.	The Journal of biological chemistry 20110902
There is more to a lipid than just being a fat: sphingolipid-guided differentiation of oligodendroglial lineage from embryonic stem cells.	Neurochemical research 20110901
The sphingosine 1-phosphate receptor modulator FTY720 prevents iodide-induced autoimmune thyroiditis in non-obese diabetic mice.	Autoimmunity 20110901
MPK6, sphinganine and the LCB2a gene from serine palmitoyltransferase are required in the signaling pathway that mediates cell death induced by long chain bases in Arabidopsis.	The New phytologist 20110901
TLR2 and TLR4 expression after kidney ischemia and reperfusion injury in mice treated with FTY720.	International immunopharmacology 20110901
Characterization of a sphingosine 1-phosphate receptor antagonist prodrug.	The Journal of pharmacology and experimental therapeutics 20110901
Sphingosine induces apoptosis in hippocampal neurons and astrocytes by activating caspase-3/-9 via a mitochondrial pathway linked to SDK/14-3-3 protein/Bax/cytochrome c.	Journal of cellular physiology 20110901
Essential roles of sphingosine 1-phosphate receptor types 1 and 3 in human hepatic stellate cells motility and activation.	Journal of cellular physiology 20110901
P2X7 receptor agonists pre- and postcondition the heart against ischemia-reperfusion injury by opening pannexin-1/P2X₇ channels.	American journal of physiology. Heart and circulatory physiology 20110901
PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism.	Protein science : a publication of the Protein Society 20110901
Human apolipoprotein A-I induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through ATP-binding cassette transporter A1.	American journal of physiology. Cell physiology 20110901
Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo.	Molecular and cellular neurosciences 20110901
FTY720 blocks egress of T cells in part by abrogation of their adhesion on the lymph node sinus.	Journal of immunology (Baltimore, Md. : 1950) 20110901
Branch retinal vein occlusion during fingolimod treatment in a patient with multiple sclerosis.	Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 20110901
New insights into cell death induced by long chain bases in Arabidopsis.	The New phytologist 20110901
Post-translational modification of 14-3-3 isoforms and regulation of cellular function.	Seminars in cell & developmental biology 20110901
A mechanistically novel, first oral therapy for multiple sclerosis: the development of fingolimod (FTY720, Gilenya).	Discovery medicine 20110901
Kinetic analysis of autotaxin reveals substrate-specific catalytic pathways and a mechanism for lysophosphatidic acid distribution.	The Journal of biological chemistry 20110826
NICE rules out NHS prescription of fingolimod for multiple sclerosis.	BMJ (Clinical research ed.) 20110810
Sphingosine-1-phosphate: a potential therapeutic target for rheumatoid arthritis.	Molecular biology reports 20110801
Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression.	American journal of respiratory cell and molecular biology 20110801
Sphingosine-1-phosphate links glycosphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism.	Cell death and differentiation 20110801
Pharmacologic evaluation of sulfasalazine, FTY720, and anti-IL-12/23p40 in a TNBS-induced Crohn's disease model.	Digestive diseases and sciences 20110801
The Sphingosine-1 Phosphate receptor agonist FTY720 dose dependently affected endothelial integrity in vitro and aggravated ventilator-induced lung injury in mice.	Pulmonary pharmacology & therapeutics 20110801
Immunosuppression with FTY720 is insufficient to prevent secondary progressive neurodegeneration in experimental autoimmune encephalomyelitis.	Multiple sclerosis (Houndmills, Basingstoke, England) 20110801
Translational aspects of sphingosine 1-phosphate biology.	Trends in molecular medicine 20110801
Metabolite modulation of HeLa cell response to ENOX2 inhibitors EGCG and phenoxodiol.	Biochimica et biophysica acta 20110801
Sphingolipid modulation of angiogenic factor expression in neuroblastoma.	Cancer prevention research (Philadelphia, Pa.) 20110801
Phosphorylation of Ser45 and Ser59 of αB-crystallin and p38/extracellular regulated kinase activity determine αB-crystallin-mediated protection of rat brain astrocytes from C2-ceramide- and staurosporine-induced cell death.	Journal of neurochemistry 20110801
Sphinganine and sphingosine levels and ratio in urine and blood samples from a Catalonian population, Spain.	Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20110801
Serine palmitoyltransferase inhibitor myriocin induces growth inhibition of B16F10 melanoma cells through G(2) /M phase arrest.	Cell proliferation 20110801
Oral fingolimod for the treatment of patients with relapsing forms of multiple sclerosis.	International journal of clinical practice 20110801
Natural product drug discovery: the successful optimization of ISP-1 and halichondrin B.	Current opinion in chemical biology 20110801
Lysosomal Ca(2+) homeostasis: role in pathogenesis of lysosomal storage diseases.	Cell calcium 20110801
Activation of matriptase zymogen.	Journal of biochemistry 20110801
Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.	Critical reviews in biochemistry and molecular biology 20110801
Fingolimod: a review of its use in the management of relapsing-remitting multiple sclerosis.	CNS drugs 20110801
Melanoma occurring during treatment with fingolimod for multiple sclerosis: a case report.	Archives of dermatology 20110801
Multiple sclerosis treatment: First oral drug, new antibody therapies.	JAAPA : official journal of the American Academy of Physician Assistants 20110801
[The study on protective effect of sphingosine-1-phosphate in cardiomyocytes].	Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20110801
Redirected tumor-specific allogeneic T cells for universal treatment of cancer.	Blood 20110728
Endogenous sphingosine 1-phosphate regulates spontaneous glutamate release from mossy fiber terminals via S1P(3) receptors.	Life sciences 20110718
Targeting lymphangiogenesis after islet transplantation prolongs islet allograft survival.	Transplantation 20110715
Sphingosine-1-phosphate acting via the S1P₁ receptor is a downstream signaling pathway in ceramide-induced hyperalgesia.	Neuroscience letters 20110715
Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA.	The Journal of biological chemistry 20110715
Multiple sclerosis: Cladribine--a contentious therapeutic contender for MS.	Nature reviews. Neurology 20110712
Sphingolipid long chain base phosphates can regulate apoptotic-like programmed cell death in plants.	Biochemical and biophysical research communications 20110708
Metabonomic study on women of reproductive age treated with nutritional intervention: screening potential biomarkers related to neural tube defects occurrence.	Biomedical chromatography : BMC 20110701
FTY720-induced human pulmonary endothelial barrier enhancement is mediated by c-Abl.	The European respiratory journal 20110701
S1P-targeted therapy for elderly rheumatoid arthritis patients with osteoporosis.	Rheumatology international 20110701
Dissecting the role of the S1P/S1PR axis in health and disease.	Journal of dental research 20110701
Pharmacological relevance and potential of sphingosine 1-phosphate in the vascular system.	British journal of pharmacology 20110701
CD69 modulates sphingosine-1-phosphate-induced migration of skin dendritic cells.	The Journal of investigative dermatology 20110701
Macrophages programmed by apoptotic cells promote angiogenesis via prostaglandin E2.	FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110701
FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells.	Autophagy 20110701
A novel lipid natriuretic factor in the renal medulla: sphingosine-1-phosphate.	American journal of physiology. Renal physiology 20110701
Role of sphingosine-1-phosphate in the renal medulla.	American journal of physiology. Renal physiology 20110701
High 1,3-trans stereoselectivity in nucleophilic substitution at the anomeric position and β-fragmentation of the primary alkoxyl radical in 3-amino-3-deoxy-ribofuranose derivatives: application to the synthesis of 2-epi-(-)-jaspine B.	The Journal of organic chemistry 20110701
A ménage à trois made in heaven: G-protein-coupled receptors, lipids and TRP channels.	Cell calcium 20110701
Reduction of the peripheral blood CD56(bright) NK lymphocyte subset in FTY720-treated multiple sclerosis patients.	Journal of immunology (Baltimore, Md. : 1950) 20110701
Discovery of S1P agonists with a dihydronaphthalene scaffold.	Bioorganic & medicinal chemistry letters 20110701
Sphingosine 1-phosphate regulates matrix metalloproteinase-9 expression and breast cell invasion through S1P3-Gαq coupling.	Journal of cell science 20110701
[Pharmacological targets in multiple sclerosis].	Revista de neurologia 20110701
Differentiation of adult stem cells into smooth muscle for vascular tissue engineering.	The Journal of surgical research 20110615
Combining anticancer agents photodynamic therapy and LCL85 leads to distinct changes in the sphingolipid profile, autophagy, caspase-3 activation in the absence of cell death, and long-term sensitization.	Biochemical and biophysical research communications 20110610
Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A.	Blood 20110602
Exogenous gangliosides increase the release of brain-derived neurotrophic factor.	Neuropharmacology 20110601
Cloning and characterization of a wheat neutral ceramidase gene Ta-CDase.	Molecular biology reports 20110601
Sphingosine 1-phosphate (S1P)/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility.	Journal of hepatology 20110601
Sphingosine 1-phosphate receptor modulator FTY720 suppresses rat experimental autoimmune prostatitis.	Scandinavian journal of immunology 20110601
Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma.	Hepatology (Baltimore, Md.) 20110601
Sphingosine-1-phosphate modulates vascular permeability and cell recruitment in acute inflammation in vivo.	The Journal of pharmacology and experimental therapeutics 20110601
Photolysis of caged sphingosine-1-phosphate induces barrier enhancement and intracellular activation of lung endothelial cell signaling pathways.	American journal of physiology. Lung cellular and molecular physiology 20110601
The outs and the ins of sphingosine-1-phosphate in immunity.	Nature reviews. Immunology 20110601
New drugs 2011 part 2.	Nursing 20110601
Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice.	The Journal of clinical investigation 20110601
Transforming multiple sclerosis trials into practical reality.	The Lancet. Neurology 20110601
Comparison of fingolimod with interferon beta-1a in relapsing-remitting multiple sclerosis: a randomised extension of the TRANSFORMS study.	The Lancet. Neurology 20110601

Actin polymerization-enhancing drugs promote ovarian follicle growth mediated by the Hippo signaling effector YAP.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20150601

FTY720 Phosphate Activates Sphingosine-1-Phosphate Receptor 2 and Selectively Couples to Gα12/13/Rho/ROCK to Induce Myofibroblast Contraction.

Molecular pharmacology 20150601

Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate.

Journal of lipid research 20150601

Apigenin attenuates heart injury in lipopolysaccharide-induced endotoxemic model by suppressing sphingosine kinase 1/sphingosine 1-phosphate signaling pathway.

Chemico-biological interactions 20150525

Lysophospholipid receptors in drug discovery.

Experimental cell research 20150501

Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3.

Journal of neuroinflammation 20150101

Resveratrol induces apoptosis of leukemia cell line K562 by modulation of sphingosine kinase-1 pathway.

International journal of clinical and experimental pathology 20150101

Downregulation of Pink1 influences mitochondrial fusion-fission machinery and sensitizes to neurotoxins in dopaminergic cells.

Neurotoxicology 20140901

Sphingosine kinase 1 and sphingosine-1-phosphate in oxidative stress evoked by 1-methyl-4-phenylpyridinium (MPP+) in human dopaminergic neuronal cells.

Molecular neurobiology 20140801

FTY720 attenuates paraquat-induced lung injury in mice.

International immunopharmacology 20140801

Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory.

Nature neuroscience 20140701

ASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile.

PloS one 20140101

Suppression of experimental autoimmune optic neuritis by the novel agent fingolimod.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 20130601

Circulating monocytes are reduced by sphingosine-1-phosphate receptor modulators independently of S1P3.

Journal of immunology (Baltimore, Md. : 1950) 20130401

Cellular assay for the characterization of sphingosine-1-phosphate lyase inhibitors.

Analytical biochemistry 20130315

Sphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 (TRPM7) channels.

British journal of pharmacology 20130301

Early tolerability and safety of fingolimod in clinical practice.

Journal of the neurological sciences 20121215

Contrary effects of sphingosine-1-phosphate on expression of α-smooth muscle actin in transforming growth factor β1-stimulated lung fibroblasts.

European journal of pharmacology 20121205

Fingolimod inhibits PDGF-B-induced migration of vascular smooth muscle cell by down-regulating the S1PR1/S1PR3 pathway.

Biochimie 20121201

Sphingosine 1-phosphate protects primary human keratinocytes from apoptosis via nitric oxide formation through the receptor subtype S1P₃.

Molecular and cellular biochemistry 20121201

Sphingosine-1-phosphate inhibits interleukin-1β-induced inflammation in human articular chondrocytes.

International journal of molecular medicine 20121201

Effect of alkyl chain length on sphingosine kinase 2 selectivity.

Bioorganic & medicinal chemistry letters 20121115

Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B.

International journal of cancer 20121101

Withdrawal of fingolimod treatment for relapsing-remitting multiple sclerosis: report of six cases.

Multiple sclerosis (Houndmills, Basingstoke, England) 20121101

Sphingopeptides: dihydrosphingosine-based fusion inhibitors against wild-type and enfuvirtide-resistant HIV-1.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20121101

Severe multiple sclerosis reactivation under fingolimod 3 months after natalizumab withdrawal.

Multiple sclerosis (Houndmills, Basingstoke, England) 20121101

Evidence for a link between histone deacetylation and Ca²+ homoeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts.

The Biochemical journal 20121101

Over-expression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis.

Journal of neurochemistry 20121101

A strategy for enrichment of the bioactive sphingoid base-1-phosphates produced by Hypericum perforatum L. in a balloon type airlift reactor.

Bioresource technology 20121101

Myocardial infarction differentially alters sphingolipid levels in plasma, erythrocytes and platelets of the rat.

Basic research in cardiology 20121101

Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity.

Endocrinology 20121101

High density lipoprotein biogenesis, cholesterol efflux, and immune cell function.

Arteriosclerosis, thrombosis, and vascular biology 20121101

Switching therapy from natalizumab to fingolimod in relapsing-remitting multiple sclerosis: clinical and magnetic resonance imaging findings.

Multiple sclerosis (Houndmills, Basingstoke, England) 20121101

Emerging tumefactive multiple sclerosis after switching therapy from natalizumab to fingolimod.

Multiple sclerosis (Houndmills, Basingstoke, England) 20121101

Focus on molecules: Sphingosine 1 Phosphate (S1P).

Experimental eye research 20121001

Sudden unexpected death on fingolimod.

Multiple sclerosis (Houndmills, Basingstoke, England) 20121001

Role of S-1-P receptors and human vascular smooth muscle cell migration in diabetes and metabolic syndrome.

The Journal of surgical research 20121001

Effects of FTY720 and rapamycin on inflammation in taurocholate-induced acute pancreatitis in the rat.

Pancreas 20121001

Phytosphingosine-1-phosphate represses the hydrogen peroxide-induced activation of c-Jun N-terminal kinase in human dermal fibroblasts through the phosphatidylinositol 3-kinase/Akt pathway.

Archives of dermatological research 20121001

Sphingosine 1-phosphate-primed astrocytes enhance differentiation of neuronal progenitor cells.

Journal of neuroscience research 20121001

Increased serum concentration of sphingosine-1-phosphate in juvenile-onset systemic lupus erythematosus.

Journal of clinical immunology 20121001

Analysis of sphingolipid and prostaglandin synthesis during zymosan-induced inflammation.

Prostaglandins & other lipid mediators 20121001

Sphingosine 1-phosphate induces MKP-1 expression via p38 MAPK- and CREB-mediated pathways in airway smooth muscle cells.

Biochimica et biophysica acta 20121001

Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate.

The Biochemical journal 20121001

New disease-modifying therapies and new challenges for MS.

Current neurology and neuroscience reports 20121001

Sphingosine-1-phosphate inhibits H2O2-induced granulosa cell apoptosis via the PI3K/Akt signaling pathway.

Fertility and sterility 20121001

Myriocin, an inhibitor of serine palmitoyl transferase, impairs the uptake of transferrin and low-density lipoprotein in mammalian cells.

Archives of biochemistry and biophysics 20121001

Erythrocyte-derived sphingosine-1-phosphate stabilizes basal hydraulic conductivity and solute permeability in rat microvessels.

American journal of physiology. Heart and circulatory physiology 20121001

Plasma sphingosine 1-phosphate levels and the risk of vertebral fracture in postmenopausal women.

The Journal of clinical endocrinology and metabolism 20121001

Sphingosine 1-phosphate and human ether-a'-go-go-related gene potassium channels modulate migration in human anaplastic thyroid cancer cells.

Endocrine-related cancer 20121001

A therapeutic approach to hyperglycaemia in the setting of acute myocardial infarction: spotlight on glucagon-like peptide 1.

Therapeutic advances in cardiovascular disease 20121001

The functional roles of S1P in immunity.

Journal of biochemistry 20121001

Stereoselective synthesis of C18-guggultetrol and C18-phytosphingosine analogues from D-fructose.

Carbohydrate research 20121001

Increased sphingoid base-1-phosphates and failure of neural tube closure after exposure to fumonisin or FTY720.

Birth defects research. Part A, Clinical and molecular teratology 20121001

Sphingolipids, lipotoxic cardiomyopathy, and cardiac failure.

Heart failure clinics 20121001

Bcl-x pre-mRNA splicing regulates brain injury after neonatal hypoxia-ischemia.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20120926

Diastereodivergent hydroxyfluorination of cyclic and acyclic allylic amines: synthesis of 4-deoxy-4-fluorophytosphingosines.

The Journal of organic chemistry 20120907

The safety risks of innovation: the FDA's Expedited Drug Development Pathway.

JAMA 20120905

A randomized, controlled trial of fingolimod (FTY720) in Japanese patients with multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England) 20120901

Evaluation of pathological effects in broilers during fumonisins and clays exposure.

Mycopathologia 20120901

A patient with Leiden V mutation, multiple sclerosis, psoriasis, and sicca syndrome: could celecoxib and fingolimod adversely affect the heart?

Cardiovascular toxicology 20120901

Tracking sphingosine metabolism and transport in sphingolipidoses: NPC1 deficiency as a test case.

Traffic (Copenhagen, Denmark) 20120901

The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: oxidative stress and the seesaw of cell survival and death.

Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20120901

Fingolimod--a sphingosine-like molecule inhibits vesicle mobility and secretion in astrocytes.

Glia 20120901

Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor.

Journal of neurophysiology 20120901

The hydrophobic mismatch determines the miscibility of ceramides in lipid monolayers.

Chemistry and physics of lipids 20120901

4-aminopyridine toxicity: a case report and review of the literature.

Journal of medical toxicology : official journal of the American College of Medical Toxicology 20120901

First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer.

Molecular cancer therapeutics 20120901

Fingolimod attenuates ceramide-induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes.

Acta neuropathologica 20120901

Myocardial infarction changes sphingolipid metabolism in the uninfarcted ventricular wall of the rat.

Lipids 20120901

Reporting of subgroup analyses from clinical trials.

The Lancet. Neurology 20120901

The role of sphingosine-1-phosphate in breast cancer tumor-induced lymphangiogenesis.

Lymphatic research and biology 20120901

Identification of serum-derived sphingosine-1-phosphate as a small molecule regulator of YAP.

Chemistry & biology 20120824

Effect of sphingosine 1-phosphate (S1P) receptor agonists FTY720 and CYM5442 on atherosclerosis development in LDL receptor deficient (LDL-R⁻/⁻) mice.

Vascular pharmacology 20120819

Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling.

Cell 20120817

S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma.

Blood 20120816

[Infections and fingolimod].

Revista de neurologia 20120816

Ethylene signaling pathway and MAPK cascades are required for AAL toxin-induced programmed cell death.

Molecular plant-microbe interactions : MPMI 20120801

PP2A and DUSP6 are involved in sphingosylphosphorylcholine-induced hypopigmentation.

Molecular and cellular biochemistry 20120801

Loss of GM3 synthase gene, but not sphingosine kinase 1, is protective against murine nephronophthisis-related polycystic kidney disease.

Human molecular genetics 20120801

Sphingosine-1-phosphate-induced airway hyper-reactivity in rodents is mediated by the sphingosine-1-phosphate type 3 receptor.

The Journal of pharmacology and experimental therapeutics 20120801

Immunosuppressive drugs on inducing Ag-specific CD4(+)CD25(+)Foxp3(+) Treg cells during immune response in vivo.

Transplant immunology 20120801

Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression.

Journal of lipid research 20120801

A fluorescent assay for ceramide synthase activity.

Journal of lipid research 20120801

Higher circulating sphingosine 1-phosphate levels are associated with lower bone mineral density and higher bone resorption marker in humans.

The Journal of clinical endocrinology and metabolism 20120801

Fenofibrate increases high-density lipoprotein and sphingosine 1 phosphate concentrations limiting abdominal aortic aneurysm progression in a mouse model.

The American journal of pathology 20120801

Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis.

EMBO molecular medicine 20120801

Changes in the cerebrospinal fluid ceramide profile after subarachnoid hemorrhage.

Stroke 20120801

Pharmacokinetics of fingolimod (FTY720) and a combined oral contraceptive coadministered in healthy women: drug-drug interaction study results.

International journal of clinical pharmacology and therapeutics 20120801

Pharmacologic manipulation of conventional outflow facility in ex vivo mouse eyes.

Investigative ophthalmology & visual science 20120801

Labeling Golgi with fluorescent ceramides.

Cold Spring Harbor protocols 20120801

Sphingosine-1-phosphate modulates expression of vascular endothelial growth factor in human articular chondrocytes: a possible new role in arthritis.

International journal of rheumatic diseases 20120801

[Effect of sphingosine 1-phosphate/sphingosine 1-phosphate receptor signal pathway on function of neutrophils].

Zhongguo shi yan xue ye xue za zhi 20120801

The sphingolipid degradation product trans-2-hexadecenal forms adducts with DNA.

Biochemical and biophysical research communications 20120720

Role of the lysophospholipid mediators lysophosphatidic acid and sphingosine 1-phosphate in lung fibrosis.

Proceedings of the American Thoracic Society 20120715

Proximal cerebral arteries develop myogenic responsiveness in heart failure via tumor necrosis factor-α-dependent activation of sphingosine-1-phosphate signaling.

Circulation 20120710

Population pharmacokinetics of fingolimod phosphate in healthy participants.

Journal of clinical pharmacology 20120701

Fingolimod potentiates the effects of sunitinib malate in a rat breast cancer model.

Breast cancer research and treatment 20120701

The utility of pharmacokinetic-pharmacodynamic modeling in the discovery and optimization of selective S1P(1) agonists.

Xenobiotica; the fate of foreign compounds in biological systems 20120701

A novel view of paroxysmal nocturnal hemoglobinuria pathogenesis: more motile PNH hematopoietic stem/progenitor cells displace normal HSPCs from their niches in bone marrow due to defective adhesion, enhanced migration and mobilization in response to erythrocyte-released sphingosine-1 phosphate gradient.

Leukemia 20120701

Metabolic engineering of the non-conventional yeast Pichia ciferrii for production of rare sphingoid bases.

Metabolic engineering 20120701

Penetration and release studies of positively and negatively charged nanoemulsions--is there a benefit of the positive charge?

International journal of pharmaceutics 20120701

IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia.

American journal of physiology. Lung cellular and molecular physiology 20120701

The sphingosine-1-phosphate receptor agonist FTY720 and its phosphorylated form affect the function of CD4+CD25+ T cells in vitro.

International journal of molecular medicine 20120701

The role of sphingosine-1-phosphate transporter Spns2 in immune system function.

Journal of immunology (Baltimore, Md. : 1950) 20120701

[Basic mechanisms of action of fingolimod in relation to multiple sclerosis].

Revista de neurologia 20120701

Decrease of serum sphingosine-1-phosphate levels in hemodialysis patients with secondary hyperparathyroidism treated with cinacalcet.

Clinical nephrology 20120701

Cost-effectiveness of early initiation of fingolimod versus delayed initiation after 1 year of intramuscular interferon beta-1a in patients with multiple sclerosis.

Clinical therapeutics 20120701

Sphingosine 1-phosphate acts as an activator for the porcine Gpr3 of constitutively active G protein-coupled receptors.

Journal of Zhejiang University. Science. B 20120701

[Effect of ceramide on GSTA1 in Caco-2 cells].

Yao xue xue bao = Acta pharmaceutica Sinica 20120701

[Therapeutic approach to mite-induced intractable dermatitis using novel immunomodulator FTY720 (fingolimod) in combination with betamethasone ointment in NC/Nga mice].

Arerugi = [Allergy] 20120701

Sphingosine 1-phosphate antagonizes the effect of all-trans retinoic acid (ATRA) in a human colon cancer cell line by modulation of RARβ expression.

Cancer letters 20120628

Sphingosine 1-phosphate receptor activation enhances BMP-2-induced osteoblast differentiation.

Biochemical and biophysical research communications 20120622

Species-specific activity of glycolipid ligands for invariant NKT cells.

Chembiochem : a European journal of chemical biology 20120618

First-line disease-modifying therapies in paediatric multiple sclerosis: a comprehensive overview.

Drugs 20120618

Biosynthesis of alkyl lysophosphatidic acid by diacylglycerol kinases.

Biochemical and biophysical research communications 20120615

In vivo efficacy of a novel liposomal formulation of safingol in the treatment of acute myeloid leukemia.

Journal of controlled release : official journal of the Controlled Release Society 20120610

Sphingosine 1-phosphate as a therapeutic target in heart failure: more questions than answers.

Circulation 20120605

Tumor necrosis factor-α-mediated downregulation of the cystic fibrosis transmembrane conductance regulator drives pathological sphingosine-1-phosphate signaling in a mouse model of heart failure.

Circulation 20120605

SRC regulates sphingosine-1-phosphate mediated smooth muscle cell migration.

The Journal of surgical research 20120601

Thiazolidinedione-dependent activation of sphingosine kinase 1 causes an anti-fibrotic effect in renal mesangial cells.

British journal of pharmacology 20120601

Serum sphingolipids and inflammatory mediators in adolescents at risk for metabolic syndrome.

Endocrine 20120601

FTY720 (fingolimod) increases vascular tone and blood pressure in spontaneously hypertensive rats via inhibition of sphingosine kinase.

British journal of pharmacology 20120601

Sphingosine-1-phosphate is a mediator of TNF-α action on the Na+/K+ ATPase in HepG2 cells.

Journal of cellular biochemistry 20120601

Decreased free sphingoid base concentration in the plasma of patients with chronic systolic heart failure.

Advances in medical sciences 20120601

H-Ras increases release of sphingosine resulting in down-regulation of TSP-1 in non-transformed cells.

International journal of experimental pathology 20120601

Analytical evaluation of plasma serotonin and sphingosine 1-phosphate and their clinical assessment in early atherosclerosis.

Coronary artery disease 20120601

Possible Involvement of Sphingosine-1-Phosphate/G(i)/RhoA pathways in adherence of eosinophils to pulmonary endothelium.

Allergology international : official journal of the Japanese Society of Allergology 20120601

Interplay between SAFE and RISK pathways in sphingosine-1-phosphate-induced cardioprotection.

Cardiovascular drugs and therapy 20120601

Ethanol triggers sphingosine 1-phosphate elevation along with neuroapoptosis in the developing mouse brain.

Journal of neurochemistry 20120601

FTY720 mediates activation suppression and G(0)/G (1) cell cycle arrest in a concanavalin A-induced mouse lymphocyte pan-activation model.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120601

Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation.

Angiogenesis 20120601

Role of sphingosine-1-phosphate inβ-adrenoceptor desensitization via Ca(2+) sensitization in airway smooth muscle.

Allergology international : official journal of the Japanese Society of Allergology 20120601

Signaling and regulatory functions of bioactive sphingolipids as therapeutic targets in multiple sclerosis.

Neurochemical research 20120601

Sphingosine mediates TNFα-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells.

Journal of lipid research 20120601

IKK NBD peptide inhibits LPS induced pulmonary inflammation and alters sphingolipid metabolism in a murine model.

Pulmonary pharmacology & therapeutics 20120601

Isoflurane delays the development of early brain injury after subarachnoid hemorrhage through sphingosine-related pathway activation in mice.

Critical care medicine 20120601

Clathrin and AP-1 regulate apical polarity and lumen formation during C. elegans tubulogenesis.

Development (Cambridge, England) 20120601

Simultaneous quantitation of sphingoid bases and their phosphates in biological samples by liquid chromatography/electrospray ionization tandem mass spectrometry.

Analytical and bioanalytical chemistry 20120601

[Assessment of the clinical and MRI results of the FREEDOMS and TRANSFORMS phase III. clinical trials].

Ideggyogyaszati szemle 20120530

The reduction of allograft arteriosclerosis in intestinal transplant is associated with sphingosine kinase 1/sphingosine-1-phosphate signaling after fish oil treatment.

Transplantation 20120527

The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway.

Molecular cell 20120525

Structure of the first sphingosine 1-phosphate receptor.

Science signaling 20120522

FTY720, sphingosine 1-phosphate receptor modulator, selectively radioprotects hippocampal neural stem cells.

Neuroscience letters 20120516

Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1.

The Biochemical journal 20120515

Attenuation by sphingosine-1-phosphate of rat microvessel acute permeability response to bradykinin is rapidly reversible.

American journal of physiology. Heart and circulatory physiology 20120515

Pharmacological effects of CS-0777, a selective sphingosine 1-phosphate receptor-1 modulator: results from a 12-week, open-label pilot study in multiple sclerosis patients.

Journal of neuroimmunology 20120515

Sphingosine analogue AAL-R increases TLR7-mediated dendritic cell responses via p38 and type I IFN signaling pathways.

Journal of immunology (Baltimore, Md. : 1950) 20120515

Building a better sphingosine kinase-1 inhibitor.

The Biochemical journal 20120515

[Multiple sclerosis: beyong first line therapies].

Revue medicale suisse 20120502

Pharmacologic recruitment of regulatory T cells as a therapy for ischemic acute kidney injury.

Kidney international 20120501

Sphingosine-1-phosphate-induced release of TIMP-2 from vascular smooth muscle cells inhibits angiogenesis.

Journal of cell science 20120501

Sphingosine-1-phosphate receptor-3 signaling up-regulates epidermal growth factor receptor and enhances epidermal growth factor receptor-mediated carcinogenic activities in cultured lung adenocarcinoma cells.

International journal of oncology 20120501

S1P2 receptor mediates sphingosine-1-phosphate-induced fibronectin expression via MAPK signaling pathway in mesangial cells under high glucose condition.

Experimental cell research 20120501

Sorafenib inhibits endogenous and IL-6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis.

Cancer biology & therapy 20120501

Specific phosphorylation of αA-crystallin is required for the αA-crystallin-induced protection of astrocytes against staurosporine and C2-ceramide toxicity.

Neurochemistry international 20120501

Low-density lipoprotein induced expression of connective tissue growth factor via transactivation of sphingosine 1-phosphate receptors in mesangial cells.

Molecular endocrinology (Baltimore, Md.) 20120501

An efficient synthesis of the polar part of sulfamisterin and its analogs.

Carbohydrate research 20120501

Annualized relapse rate of first-line treatments for multiple sclerosis: a meta-analysis, including indirect comparisons versus fingolimod.

Current medical research and opinion 20120501

Miglustat improves purkinje cell survival and alters microglial phenotype in feline Niemann-Pick disease type C.

Journal of neuropathology and experimental neurology 20120501

MS clinical trials: what can subgroup analyses teach us?

The Lancet. Neurology 20120501

Relapse and disability outcomes in patients with multiple sclerosis treated with fingolimod: subgroup analyses of the double-blind, randomised, placebo-controlled FREEDOMS study.

The Lancet. Neurology 20120501

Harnessing regulatory T cells for therapeutic purposes.

Kidney international 20120501

Immunotherapies in neurologic disorders.

The Medical clinics of North America 20120501

Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia.

Nature 20120426

Lysophosphatidic acid and sphingosine-1-phosphate promote morphogenesis and block invasion of prostate cancer cells in three-dimensional organotypic models.

Oncogene 20120419

[New disease-modifying and symptomatic therapies for multiple sclerosis].

MMW Fortschritte der Medizin 20120419

Treatment with a sphingosine-1-phosphate analog inhibits airway remodeling following repeated allergen exposure.

American journal of physiology. Lung cellular and molecular physiology 20120415

Sphingosine 1-phosphate (S1P) regulates glucose-stimulated insulin secretion in pancreatic beta cells.

The Journal of biological chemistry 20120413

Drugs: An injection of hope.

Nature 20120412

Autophagy induced by FTY720 promotes apoptosis in U266 cells.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120411

CCR7/CCL19 controls expression of EDG-1 in T cells.

The Journal of biological chemistry 20120406

The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice.

The Journal of clinical investigation 20120402

Treatments for relapsing-remitting multiple sclerosis: summarising current information by network meta-analysis.

European journal of clinical pharmacology 20120401

Placebo-controlled study of the effects of fingolimod on cardiac rate and rhythm and pulmonary function in healthy volunteers.

European journal of clinical pharmacology 20120401

Reactivating PP2A by FTY720 as a novel therapy for AML with C-KIT tyrosine kinase domain mutation.

Journal of cellular biochemistry 20120401

Regulation of metabolism and transport of sphingosine-1-phosphate in mammalian cells.

Molecular and cellular biochemistry 20120401

Senescent endothelial dysfunction is attributed to the up-regulation of sphingosine-1-phosphate receptor-2 in aged rats.

Molecular and cellular biochemistry 20120401

Methylation of glycosylated sphingolipid modulates membrane lipid topography and pathogenicity of Cryptococcus neoformans.

Cellular microbiology 20120401

Reactive murine lymph nodes uniquely permit parenchymal access for T cells that enter via the afferent lymphatics.

The Journal of pathology 20120401

A polysaccharides MDG-1 augments survival in the ischemic heart by inducing S1P release and S1P1 expression.

International journal of biological macromolecules 20120401

Pharmacological mechanisms of black cohosh in Sprague-Dawley rats.

Fitoterapia 20120401

Phytosphingosine-phosphate is a signal for AtMPK6 activation and Arabidopsis response to chilling.

The New phytologist 20120401

Sphingosine pathway deregulation in endometriotic tissues.

Fertility and sterility 20120401

Sphingosine-1-phosphate receptor 3 promotes neointimal hyperplasia in mouse iliac-femoral arteries.

Arteriosclerosis, thrombosis, and vascular biology 20120401

Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin α(v)β(6)-dependent physical force.

Experimental cell research 20120401

Rapid histamine-induced neutrophil recruitment is sphingosine kinase-1 dependent.

The American journal of pathology 20120401

An efficient and convenient formal synthesis of Jaspine B from D-xylose.

Carbohydrate research 20120401

Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma.

Neuro-oncology 20120401

Evidence that sphingolipid signaling is involved in responding to low temperature.

The New phytologist 20120401

Anti-proliferative effects of the novel ceramide analog (S)-2-(benzylideneamino)-3-hydroxy-N-tetrade-cylpropanamide in chemoresistant cancer.

Bioorganic & medicinal chemistry letters 20120401

FTY720 improves functional recovery after spinal cord injury by primarily nonimmunomodulatory mechanisms.

The American journal of pathology 20120401

Network analysis of randomized controlled trials in multiple sclerosis.

Clinical therapeutics 20120401

[2012: Update on diagnosis and treatment of multiple sclerosis].

Deutsche medizinische Wochenschrift (1946) 20120401

Fingolimod: cardiovascular deaths.

Prescrire international 20120401

Discovery of fingolimod, the sphingosine 1-phosphate receptor modulator and its application for the therapy of multiple sclerosis.

Future medicinal chemistry 20120401

Protein phosphatase 1α mediates ceramide-induced ERM protein dephosphorylation: a novel mechanism independent of phosphatidylinositol 4, 5-biphosphate (PIP2) and myosin/ERM phosphatase.

The Journal of biological chemistry 20120323

Blocking S1P interaction with S1P₁ receptor by a novel competitive S1P₁-selective antagonist inhibits angiogenesis.

Biochemical and biophysical research communications 20120323

Severe multiple sclerosis relapse under fingolimod therapy: incident or coincidence?

Neurology 20120320

S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release.

Blood 20120315

Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis.

European journal of pharmacology 20120315

Synthesis of amino core compounds of galactosyl phytosyl ceramide analogs for developing iNKT-cell inducers.

Molecules (Basel, Switzerland) 20120312

Connections between sphingosine kinase and phospholipase D in the abscisic acid signaling pathway in Arabidopsis.

The Journal of biological chemistry 20120309

Sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling regulates receptor activator of NF-κB ligand (RANKL) expression in rheumatoid arthritis.

Biochemical and biophysical research communications 20120309

Local delivery of FTY720 accelerates cranial allograft incorporation and bone formation.

Cell and tissue research 20120301

Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages.

European journal of immunology 20120301

High-level production of tetraacetyl phytosphingosine (TAPS) by combined genetic engineering of sphingoid base biosynthesis and L-serine availability in the non-conventional yeast Pichia ciferrii.

Metabolic engineering 20120301

Co-regulation of transcellular and paracellular leak across microvascular endothelium by dynamin and Rac.

The American journal of pathology 20120301

Prevention of GVHD and graft rejection by a new S1P receptor agonist, W-061, in rat small bowel transplantation.

Transplant immunology 20120301

Sphingosine-1-phosphate induces contraction of valvular interstitial cells from porcine aortic valves.

Cardiovascular research 20120301

Targeting sphingosine kinase-1 to inhibit melanoma.

Pigment cell & melanoma research 20120301

Metabolic profiling based on LC/MS to evaluate unintended effects of transgenic rice with cry1Ac and sck genes.

Plant molecular biology 20120301

Terpene alcohols inhibit de novo sphingolipid biosynthesis.

Planta medica 20120301

Bioactive sphingolipids in docetaxel-induced apoptosis in human prostate cancer cells.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20120301

LC-MS/MS determination of FTY720 and FTY720-phosphate in murine intracellular compartments and human plasma.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120301

FTY720-induced blockage of autophagy enhances anticancer efficacy of milatuzumab in mantle cell lymphoma: is FTY720 the next autophagy-blocking agent in lymphoma treatment?

Autophagy 20120301

FTY720 on the way from the base camp to the summit of the mountain: relevance for remyelination.

Multiple sclerosis (Houndmills, Basingstoke, England) 20120301

Fingolimod blocks immunosurveillance of myeloma and B-cell lymphoma resulting in cancer development in mice.

Blood 20120301

[Effect of sphingosine-1-phosphate on chemotherapy-induced ovarian damage and on the efficacy of chemotherapy in mice bearing S180 tumor].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20120301

[Ca2+ and sphingolipids as modulators for apoptosis and cancer].

Investigacion clinica 20120301

Comparative effects of fumonisins on sphingolipid metabolism and toxicity in ducks and turkeys.

Avian diseases 20120301

Immunological function of sphingosine 1-phosphate in the intestine.

Nutrients 20120301

Simvastatin inhibits sphingosylphosphorylcholine-induced differentiation of human mesenchymal stem cells into smooth muscle cells.

Experimental & molecular medicine 20120227

Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection.

British journal of cancer 20120227

Fingolimod-associated macular edema: incidence, detection, and management.

Neurology 20120227

Agency is under fire for refusing to supply details of sudden deaths after first dose of multiple sclerosis drug.

BMJ (Clinical research ed.) 20120223

ABCA1, ABCG1, and SR-BI: Transit of HDL-associated sphingosine-1-phosphate.

Clinica chimica acta; international journal of clinical chemistry 20120218

FTY720 normalizes hyperglycemia by stimulating β-cell in vivo regeneration in db/db mice through regulation of cyclin D3 and p57(KIP2).

The Journal of biological chemistry 20120217

Analysis of sphingosine-1-phosphate signaling mutants reveals endodermal requirements for the growth but not dorsoventral patterning of jaw skeletal precursors.

Developmental biology 20120215

Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy.

Oncogene 20120202

Sphingosine-1-phosphate attenuates lung injury induced by intestinal ischemia/reperfusion in mice: role of inducible nitric-oxide synthase.

Inflammation 20120201

Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.

Acta physiologica (Oxford, England) 20120201

Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide.

International journal of cancer 20120201

Integration of transient receptor potential canonical channels with lipids.

Acta physiologica (Oxford, England) 20120201

Oral fingolimod rescues the functional deficits of synapses in experimental autoimmune encephalomyelitis.

British journal of pharmacology 20120201

Targeting synaptic pathology in multiple sclerosis: fingolimod to the rescue?

British journal of pharmacology 20120201

[Fingolimod treatment for multiple sclerosis patients. Infectiological aspects and recommendations for vaccinations].

Der Nervenarzt 20120201

Inhibitors of specific ceramide synthases.

Biochimie 20120201

Distinct generation, pharmacology, and distribution of sphingosine 1-phosphate and dihydrosphingosine 1-phosphate in human neural progenitor cells.

Neuropharmacology 20120201

Sphingosine 1-phosphate-mediated α1B-adrenoceptor desensitization and phosphorylation. Direct and paracrine/autocrine actions.

Biochimica et biophysica acta 20120201

S1P(1) receptor modulation with cyclical recovery from lymphopenia ameliorates mouse model of multiple sclerosis.

Molecular pharmacology 20120201

Inhibition of sphingosine 1-phosphate receptor 2 protects against renal ischemia-reperfusion injury.

Journal of the American Society of Nephrology : JASN 20120201

Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition.

Thorax 20120201

Therapeutic dosing of fingolimod (FTY720) prevents cell infiltration, rapidly suppresses ocular inflammation, and maintains the blood-ocular barrier.

The American journal of pathology 20120201

Sphingosine kinase 1 knockdown reduces insulin synthesis and secretion in a rat insulinoma cell line.

Archives of biochemistry and biophysics 20120201

Immune regulation by sphingosine 1-phosphate and its receptors.

Archivum immunologiae et therapiae experimentalis 20120201

Sphingosine 1-phosphate stimulates proliferation and migration of satellite cells: role of S1P receptors.

Biochimica et biophysica acta 20120201

Sphingosine-sphingosine-1-phosphate pathway regulates trophoblast differentiation and syncytialization.

Reproductive biomedicine online 20120201

Lipid ingredients in moisturizers can modulate skin responses to UV in barrier-disrupted human skin in vivo.

Journal of dermatological science 20120201

Does fingolimod in multiple sclerosis patients cause macular edema?

Journal of neurology 20120201

Sphingosine 1-phosphate signalling in cancer.

Biochemical Society transactions 20120201

Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways.

Cell cycle (Georgetown, Tex.) 20120201

Determination of sphingosine-1-phosphate lyase activity by gas chromatography coupled to electron impact mass spectrometry.

Chemistry and physics of lipids 20120201

Application of ultra-performance liquid chromatography coupled with mass spectrometry to metabonomic study on spontaneously hypertensive rats and intervention effects of Ping Gan prescription.

Journal of separation science 20120201

Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis.

Cancer research 20120201

Fingolimod for multiple sclerosis.

Drug and therapeutics bulletin 20120201

Rebound of disease activity after withdrawal of fingolimod (FTY720) treatment.

Archives of neurology 20120201

Synthesis and immunomodulating activity of new analogues of fingolimod.

Archiv der Pharmazie 20120201

[Role of S1P acting both inside and outside the cells].

Seikagaku. The Journal of Japanese Biochemical Society 20120201

[Antitumor effect of sphingosine kinase 1 inhibitor in combination with chemotherapy on SGC7901 gastric cancer cells in vitro].

Zhonghua zhong liu za zhi [Chinese journal of oncology] 20120201

Fingolimod for multiple sclerosis.

The New England journal of medicine 20120126

Fast simultaneous quantitative analysis of FTY720 and its metabolite FTY720-P in human blood by on-line solid phase extraction coupled with liquid chromatography-tandem mass spectrometry.

Journal of pharmaceutical and biomedical analysis 20120125

Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice.

Blood 20120119

PBSCs Sphingoling along S1P/S1P1 axis.

Blood 20120119

Bioactive lipids from the sponge Spirastrella abata.

Bioorganic & medicinal chemistry letters 20120115

[Neurology].

Revue medicale suisse 20120111

Sphingosine-1-phosphate rapidly increases cortisol biosynthesis and the expression of genes involved in cholesterol uptake and transport in H295R adrenocortical cells.

Molecular and cellular endocrinology 20120102

Fingolimod in multiple sclerosis: mechanisms of action and clinical efficacy.

Clinical immunology (Orlando, Fla.) 20120101

Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia-reperfusion.

Journal of hepatology 20120101

Conditioning for hematopoietic transplantation activates the complement cascade and induces a proteolytic environment in bone marrow: a novel role for bioactive lipids and soluble C5b-C9 as homing factors.

Leukemia 20120101

Sphingosine 1-phosphate in coagulation and inflammation.

Seminars in immunopathology 20120101

The sphingosine-1-phosphate receptor agonist FTY720 prevents the development of anti-glomerular basement membrane glomerulonephritis.

Molecular biology reports 20120101

Increased interaction of connexin43 with zonula occludens-1 during inhibition of gap junctions by G protein-coupled receptor agonists.

Cellular signalling 20120101

Nuclear sphingolipid metabolism.

Annual review of physiology 20120101

Role of FAK in S1P-regulated endothelial permeability.

Microvascular research 20120101

Sphingosylphosphorylcholine induces stress fiber formation via activation of Fyn-RhoA-ROCK signaling pathway in fibroblasts.

Cellular signalling 20120101

The natural cardioprotective particle HDL modulates connexin43 gap junction channels.

Cardiovascular research 20120101

Absence of integrin αvβ3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation.

American journal of respiratory and critical care medicine 20120101

Sphingosine-1-phosphate signaling and its role in disease.

Trends in cell biology 20120101

CCR7 with S1P1 signaling through AP-1 for migration of Foxp3+ regulatory T-cells controls autoimmune exocrinopathy.

The American journal of pathology 20120101

Sphingosine in plants--more riddles from the Sphinx?

The New phytologist 20120101

Novel immunomodulators based on an oxazolin-2-one-4-carboxamide scaffold.

Bioorganic & medicinal chemistry letters 20120101

Amelioration of collagen-induced arthritis by a novel S1P1 antagonist with immunomodulatory activities.

Journal of immunology (Baltimore, Md. : 1950) 20120101

Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors.

Bioorganic & medicinal chemistry 20120101

Human vascular endothelial cells reduce sphingosylphosphorylcholine-induced smooth muscle cell contraction in co-culture system through integrin β4 and Fyn.

Acta pharmacologica Sinica 20120101

Development of extensive brain lesions following fingolimod (FTY720) treatment in a patient with neuromyelitis optica spectrum disorder.

Multiple sclerosis (Houndmills, Basingstoke, England) 20120101

Clinical pharmacokinetics of fingolimod.

Clinical pharmacokinetics 20120101

Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs.

Annual review of immunology 20120101

Structure-activity relationship studies of S1P agonists with a dihydronaphthalene scaffold.

Bioorganic & medicinal chemistry letters 20120101

Both exogenous commensal and endogenous self antigens stimulate T cell proliferation under lymphopenic conditions.

Cellular immunology 20120101

Molecular and functional characterization of the ceramide synthase from Trypanosoma cruzi.

Molecular and biochemical parasitology 20120101

The ligand binding region of the sigma-1 receptor: studies utilizing photoaffinity probes, sphingosine and N-alkylamines.

Current pharmaceutical design 20120101

Sphingosine kinase 1 mediation of expression of the anaphylatoxin receptor C5L2 dampens the inflammatory response to endotoxin.

PloS one 20120101

FTY720 suppresses liver tumor metastasis by reducing the population of circulating endothelial progenitor cells.

PloS one 20120101

Sphingosine-1 phosphate prevents ethanol-induced corneal epithelial apoptosis.

Indian journal of ophthalmology 20120101

[Research progress of the selective sphingosine-1-phosphate receptor 1 agonists].

Yao xue xue bao = Acta pharmaceutica Sinica 20120101

Small molecule inhibitors of the Pyk2 and FAK kinases modulate chemoattractant-induced migration, adhesion and Akt activation in follicular and marginal zone B cells.

Cellular immunology 20120101

Topical application of FTY720 and cyclosporin A prolong corneal graft survival in mice.

Molecular vision 20120101

Biochemical methods for quantifying sphingolipids: ceramide, sphingosine, sphingosine kinase-1 activity, and sphingosine-1-phosphate.